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1. Benefit from sacubitril/valsartan is associated with hemodynamic improvement in heart failure with reduced ejection fraction: An echocardiographic study

Author

Carluccio, Erberto, Dini, Frank L., Bitto, Roberto, Ciccarelli, Michele, Correale, Michele, D'Agostino, Andreina, Dattilo, Giuseppe, Ferretti, Marco, Grelli, Arianna, Guida, Stefania, Jacoangeli, Francesca, Lupi, Laura, Luschi, Lorenzo, Masarone, Daniele, Mercurio, Valentina, Pacileo, Giuseppe, Pugliese, Nicola Riccardo, Rispoli, Antonella, Scelsi, Laura, Tocchetti, Carlo Gabriele, Brunetti, Natale Daniele, Palazzuoli, Alberto, Piepoli, Massimo, Nodari, Savina, and Ambrosio, Giuseppe

Published
2022
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2. Echocardiographically defined haemodynamic categorization predicts prognosis in ambulatory heart failure patients treated with sacubitril/valsartan

Author

Dini, Frank L, Carluccio, Erberto, Bitto, Roberto, Ciccarelli, Michele, Correale, Michele, D'Agostino, Andreina, Dattilo, Giuseppe, Ferretti, Marco, Grelli, Arianna, Guida, Stefania, Jacoangeli, Francesca, Lupi, Laura, Luschi, Lorenzo, Masarone, Daniele, Mercurio, Valentina, Pacileo, Giuseppe, Pugliese, Nicola Riccardo, Rispoli, Antonella, Scelsi, Laura, Tocchetti, Carlo Gabriele, Brunetti, Natale Daniele, Palazzuoli, Alberto, Piepoli, Massimo, Nodari, Savina, Ambrosio, Giuseppe, Dini, Frank L, Carluccio, Erberto, Bitto, Roberto, Ciccarelli, Michele, Correale, Michele, D'Agostino, Andreina, Dattilo, Giuseppe, Ferretti, Marco, Grelli, Arianna, Guida, Stefania, Jacoangeli, Francesca, Lupi, Laura, Luschi, Lorenzo, Masarone, Daniele, Mercurio, Valentina, Pacileo, Giuseppe, Pugliese, Nicola Riccardo, Rispoli, Antonella, Scelsi, Laura, Tocchetti, Carlo Gabriele, Brunetti, Natale Daniele, Palazzuoli, Alberto, Piepoli, Massimo, Nodari, Savina, and Ambrosio, Giuseppe

Subjects
Aminobutyrates, Biphenyl Compounds, Hemodynamics, ejection fraction, haemodynamic, heart failure, prognosis, sacubitril/valsartan, Stroke Volume, Settore MED/11 - Malattie dell'Apparato Cardiovascolare, Humans, Valsartan, Cardiology and Cardiovascular Medicine, prognosi
Abstract

Aim: Echo-derived haemodynamic classification, based on forward-flow and left ventricular (LV) filling pressure (LVFP) correlates, has been proposed to phenotype patients with heart failure and reduced ejection fraction (HFrEF). To assess the prognostic relevance of baseline echocardiographically defined haemodynamic profile in ambulatory HFrEF patients before starting sacubitril/valsartan. Methods and results: In our multicentre, open-label study, HFrEF outpatients were classified into 4 groups according to the combination of forward flow (cardiac index; CI:< or ≥2.0 L/min/m2 ) and early transmitral Doppler velocity/early diastolic annular velocity ratio (E/e': ≥ or

Published
2022

3. Benefit from sacubitril/valsartan is associated with hemodynamic improvement in heart failure with reduced ejection fraction: An echocardiographic study

Author

Erberto, Carluccio, Dini, Frank L., Bitto, Roberto, Michele, Ciccarelli, Michele, Correale, Andreina, D’Agostino, Dattilo, Giuseppe, Marco, Ferretti, Arianna, Grelli, Stefania, Guida, Francesca, Jacoangeli, Laura, Lupi, Lorenzo, Luschi, Daniele, Masarone, Valentina, Mercurio, Giuseppe, Pacileo, Nicola Riccardo Pugliese, Antonella, Rispoli, Laura, Scelsi, Carlo Gabriele Tocchetti, Natale Daniele Brunetti, Alberto, Palazzuoli, Massimo, Piepoli, Savina, Nodari, Giuseppe, Ambrosio, Working Group on Heart Failure of the Italian Society of, Cardiology., Carluccio, Erberto, Dini, Frank L., Bitto, Roberto, Ciccarelli, Michele, Correale, Michele, D'Agostino, Andreina, Dattilo, Giuseppe, Ferretti, Marco, Grelli, Arianna, Guida, Stefania, Jacoangeli, Francesca, Lupi, Laura, Luschi, Lorenzo, Masarone, Daniele, Mercurio, Valentina, Pacileo, Giuseppe, Pugliese, Nicola Riccardo, Rispoli, Antonella, Scelsi, Laura, Tocchetti, Carlo Gabriele, Brunetti, Natale Daniele, Palazzuoli, Alberto, Piepoli, Massimo, Nodari, Savina, and Ambrosio, Giuseppe

Subjects
Ejection fraction, Heart failure, Hemodynamic, Prognosis, Sacubitril/valsartan, Aminobutyrates, Biphenyl Compounds, Hemodynamics, Tetrazoles, Heart failure, Ejection fraction, Hemodynamic, Prognosis, Sacubitril/valsartan, Stroke Volume, Angiotensin Receptor Antagonists, Drug Combinations, Treatment Outcome, Echocardiography, Humans, Valsartan, Cardiology and Cardiovascular Medicine
Abstract

Sacubitril/valsartan improves outcome in patients with heart failure (HF) with reduced left ventricular (LV) ejection fraction (EF, HFrEF). However, little is known about possible mechanisms underlying this favourable effect.To assess changes in echocardiographically-derived hemodynamic profiles induced by sacubitril/valsartan and their impact on outcome.In this multicenter, open-label study, 727 HFrEF outpatients underwent comprehensive echocardiography at baseline (before starting sacubitril/valsartan) and after 12 months. Estimated LV filling pressure (E/e') and cardiac index (CI, l/min/mAt baseline, 29% had profile-A, 15% had profile-B, 32% profile-C, and 24% profile-D. After 12 months, the hemodynamic profile improved in 53% of patients (all profile-A achievers, or profile-D patients achieving either C or B profile), while it remained unchanged in 39% patients and worsened in 9%. Prevalence of improved profile progressively increased with increasing dose of sacubitril/valsartan (P 0.0001). After the second echocardiography, patients were followed up 12.6 ± 7.6 months: event-rate was lower in patients with improved profile (12.3%, 95%CI: 9.4-16.1) compared to patients in whom hemodynamic profile remained unchanged (29.9%, 24.0-37.3) or worsened (31.2%, 20.7-46.9, P 0.0001). Improved hemodynamic profile was associated with favourable outcome independent of LVEF and other covariates (HR 0.65, 95%CI: 0.45-0.95, P 0.05).In HFrEF patients, the beneficial prognostic effects of sacubitril/valsartan are associated with improvement in hemodynamic conditions.

Published
2022

4. Trend of perceived quality of life and functional capacity in outpatients with chronic heart failure and in treatment with sacubitril/valsartan: a real-life experience

Author

DATTILO, Giuseppe, primary, BITTO, Roberto, additional, CORREALE, Michele, additional, MORABITO, Claudia, additional, VACCARO, Vittoria, additional, LATERRA, Giulia, additional, CASALE, Matteo, additional, CREA, Pasquale, additional, DI BELLA, Gianluca, additional, LUZZA, Francesco, additional, MIGLIORATO, Alessandro, additional, KATSIKI, Niki, additional, and DE GREGORIO, Cesare, additional

Published
2022
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6. Diagnosis of type 2 Brugada pattern: insights from a pilot survey

Author

CREA, Pasquale, primary, RIVETTI, Luigi, additional, BITTO, Roberto, additional, NICOTERA, Angela, additional, ZAPPIA, Luca, additional, CARACCIOLO, Alessandro, additional, SCALISE, Renato, additional, SALITO, Armando, additional, MAZZONE, Paolo, additional, PELLEGRINO, Nicolò, additional, CREA, Bruna, additional, DATTILO, Giuseppe, additional, LUZZA, Francesco, additional, and ORETO, Giuseppe, additional

Published
2021
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8. Diagnosis of type 2 Brugada pattern: insights from a pilot survey

Author

CREA, Pasquale, primary, RIVETTI, Luigi, additional, BITTO, Roberto, additional, NICOTERA, Angela, additional, ZAPPIA, Luca, additional, CARACCIOLO, Alessandro, additional, SCALISE, Renato, additional, SALITO, Armando, additional, MAZZONE, Paolo, additional, PELLEGRINO, Nicolò, additional, CREA, Bruna, additional, DATTILO, Giuseppe, additional, LUZZA, Francesco, additional, and ORETO, Giuseppe, additional

Published
2020
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9. Echocardiographically defined haemodynamic categorization predicts prognosis in ambulatory heart failure patients treated with sacubitril/valsartan.

Author

Dini, Frank L., Carluccio, Erberto, Bitto, Roberto, Ciccarelli, Michele, Correale, Michele, D'Agostino, Andreina, Dattilo, Giuseppe, Ferretti, Marco, Grelli, Arianna, Guida, Stefania, Jacoangeli, Francesca, Lupi, Laura, Luschi, Lorenzo, Masarone, Daniele, Mercurio, Valentina, Pacileo, Giuseppe, Pugliese, Nicola Riccardo, Rispoli, Antonella, Scelsi, Laura, and Tocchetti, Carlo Gabriele

Subjects
ECHOCARDIOGRAPHY, HEART failure patients, ENTRESTO
Abstract

Aim: Echo‐derived haemodynamic classification, based on forward‐flow and left ventricular (LV) filling pressure (LVFP) correlates, has been proposed to phenotype patients with heart failure and reduced ejection fraction (HFrEF). To assess the prognostic relevance of baseline echocardiographically defined haemodynamic profile in ambulatory HFrEF patients before starting sacubitril/valsartan. Methods and results: In our multicentre, open‐label study, HFrEF outpatients were classified into 4 groups according to the combination of forward flow (cardiac index; CI:< or ≥2.0 L/min/m2) and early transmitral Doppler velocity/early diastolic annular velocity ratio (E/e′: ≥ or <15): Profile‐A: normal‐flow, normal‐pressure; Profile‐B: low‐flow, normal‐pressure; Profile‐C: normal‐flow, high‐pressure; Profile‐D: low‐flow, high‐pressure. Patients were started on sacubitril/valsartan and followed‐up for 12.3 months (median). Rates of the composite of death/HF‐hospitalization were assessed by multivariable Cox proportional‐hazards models. Twelve sites enrolled 727 patients (64 ± 12 year old; LVEF: 29.8 ± 6.2%). Profile‐D had more comorbidities and worse renal and LV function. Target dose of sacubitril/valsartan (97/103 mg BID) was more likely reached in Profile‐A (34%) than other profiles (B: 32%, C: 24%, D: 28%, P < 0.001). Event‐rate (per 100 patients per year) progressively increased from Profile‐A to Profile‐D (12.0%, 16.4%, 22.9%, and 35.2%, respectively, P < 0.0001). By covariate‐adjusted Cox model, profiles with low forward‐flow (B and D) remained associated with poor outcome (P < 0.01). Adding this categorization to MAGGIC‐score and natriuretic peptides, provided significant continuous net reclassification improvement (0.329; P < 0.001). Intermediate and high‐dose sacubitril/valsartan reduced the event's risk independently of haemodynamic profile. Conclusions: Echocardiographically‐derived haemodynamic classification identifies ambulatory HFrEF patients with different risk profiles. In real‐world HFrEF outpatients, sacubitril/valsartan is effective in improving outcome across different haemodynamic profiles. [ABSTRACT FROM AUTHOR]

Published
2022
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10. Treatment with sacubitril/valsartan is associated with hemodynamic improvement in outpatients with heart failure with reduced ejection fraction: an echocardiographic study

Author

Michele, Correale, Frank Lloyd Dini, Erberto, Carluccio, Bitto, Roberto, Ciccarelli, Michele, Andreina, D'Agostino, Dattilo, Giuseppe, Marco, Ferretti, Arianna, Grelli, Stefania, Guida, Lupi, Laura, Lorenzo, Luschi, Daniele, Masarone, Valentina, Mercurio, Mario, Miccoli, Giuseppe, Pacileo, Nicola Riccardo Pugliese, Antonella, Rispoli, Laura, Scelsi, Carlo Gabriele Tocchetti, Natale Daniele Brunetti, Alberto, Palazzuoli, Massimo, Piepoli, Savina, Nodari, and Giuseppe Ambrosio, and On Behalf Of The Working Group On Heart Failure

Published
2020

13. Cardiovascular Risk in Psoriasis: Current State of the Art

Author

Dattilo, Giuseppe, primary, Borgia, Francesco, additional, Guarneri, Claudio, additional, Casale, Matteo, additional, Bitto, Roberto, additional, Morabito, Claudia, additional, Signorelli, Salvatore, additional, Katsiki, Niki, additional, and Cannavò, Serafinello P., additional

Published
2018
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16. Prevalence, predictors and prognostic impact of reverse left ventricular remodelling in outpatients with heart failure with reduced ejection fraction treated with sacubitril/valsartan. A real world study

Author

Benedetti, Martina, Carluccio, Erberto, Dini, Frank Lloyd, Bitto, Roberto, Ciccarelli, Michele, Correale, Michele, D Agostino, Andreina, Dattilo, Giuseppe, Ferretti, Marco, Grelli, Arianna, Guida, Stefania, Lupi, Laura, Luschi, Lorenzo, Masarone, Daniele, Mercurio, Valentina, Miccoli, Mario, Pacileo, Giuseppe, Pugliese, Nicola Riccardo, Rispoli, Antonella, Scelsi, Laura, Tocchetti, Carlogabriele, Brunetti, Natale Daniele, Palazzuoli, Alberto, Massimo Piepoli, Nodari, Savina, and Ambrosio, Giuseppe

17. Cardiovascular Risk in Psoriasis: Current State of the Art.

Author

Dattilo G, Borgia F, Guarneri C, Casale M, Bitto R, Morabito C, Signorelli S, Katsiki N, and Cannavò SP

Subjects
Cardiovascular Diseases diagnosis, Cardiovascular Diseases prevention & control, Humans, Prognosis, Psoriasis diagnosis, Psoriasis therapy, Risk Assessment, Risk Factors, Severity of Illness Index, Cardiovascular Diseases epidemiology, Psoriasis epidemiology
Abstract

Psoriasis (Pso) is a chronic inflammatory immune-mediated skin disease associated with several comorbidities. Despite the growing number of studies providing evidence for the link between Pso and Cardiovascular (CV) disorders, there are still many unsolved questions, dealing with the role of the skin disease as an independent risk factor for CV events, the influence of Pso severity and duration on CV damage, the presence of Psoriatic Arthritis (PsA) as a predictor of increased CV mortality and morbidity and the detection of reliable clinical, laboratory and/or instrumental parameters to stratify CV risk in psoriatic patients. Moreover, it remains to clarify if the early treatment of the dermatosis may lower CV risk. In this paper we will try to provide answers to these queries in the light of the updated data of the literature., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)

Published
2019
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