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2. CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia is sensitive to BCL-XL inhibition by navitoclax and DT2216

Author

Gress, Verena, Roussy, Mathieu, Boulianne, Luc, Bilodeau, Mélanie, Cardin, Sophie, El-Hachem, Nehme, Lisi, Véronique, Khakipoor, Banafsheh, Rouette, Alexandre, Farah, Azer, Théret, Louis, Aubert, Léo, Fatima, Furat, Audemard, Éric, Thibault, Pierre, Bonneil, Éric, Chagraoui, Jalila, Laramée, Louise, Gendron, Patrick, Jouan, Loubna, Jammali, Safa, Paré, Bastien, Simpson, Shawn M., Tran, Thai Hoa, Duval, Michel, Teira, Pierre, Bittencourt, Henrique, Santiago, Raoul, Barabé, Frédéric, Sauvageau, Guy, Smith, Martin A., Hébert, Josée, Roux, Philippe P., Gruber, Tanja A., Lavallée, Vincent-Philippe, Wilhelm, Brian T., and Cellot, Sonia

Published
2024
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3. Association of busulfan exposure and outcomes after HCT for patients with an inborn error of immunity

Author

Bognàr, Tim, Garcia-Rosa, Moises, Lalmohamed, Arief, Güngör, Tayfun, Hauri-Hohl, Mathias, Prockop, Susan, Oram, Layne, Pai, Sung-Yun, Brooks, Jordan, Savic, Rada M., Dvorak, Christopher C., Long-Boyle, Janel R., Krajinovic, Maja, Bittencourt, Henrique, Teyssier, Anne-Charlotte, Théorêt, Yves, Martinez, Cary, Egberts, Toine C. G., Morales, Erin, Slatter, Mary, Cuvelier, Geoffrey D. E., Chiesa, Robert, Wynn, Robert F., Coussons, Mary, Cicalese, Maria P., Ansari, Marc, Long, Susan E., Ebens, Christen L., Lust, Hannah, Chaudhury, Sonali, Nath, Christa E., Shaw, Peter J., Keogh, Steven J., van der Stoep, M. Y. Eileen C., Bredius, Robbert, Lindemans, Caroline A., Boelens, Jaap-Jan, and Bartelink, Imke H.

Published
2024
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6. A diagnostic classifier for pediatric chronic graft-versus-host disease: results of the ABLE/PBMTC 1202 study

Author

Cuvelier, Geoffrey D. E., Ng, Bernard, Abdossamadi, Sayeh, Nemecek, Eneida R., Melton, Alexis, Kitko, Carrie L., Lewis, Victor A., Schechter, Tal, Jacobsohn, David A., Harris, Andrew C., Pulsipher, Michael A., Bittencourt, Henrique, Choi, Sung Won, Caywood, Emi H., Kasow, Kimberly A., Bhatia, Monica, Oshrine, Benjamin R., Chaudhury, Sonali, Coulter, Donald, Chewning, Joseph H., Joyce, Michael, Savaşan, Süreyya, Pawlowska, Anna B., Megason, Gail C., Mitchell, David, Cheerva, Alexandra C., Lawitschka, Anita, Ostroumov, Elena, and Schultz, Kirk R.

Published
2023
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8. Outcome of children with multiply relapsed B-cell acute lymphoblastic leukemia: a therapeutic advances in childhood leukemia & lymphoma study

Author

Sun, Weili, Malvar, Jemily, Sposto, Richard, Verma, Anupam, Wilkes, Jennifer J, Dennis, Robyn, Heym, Kenneth, Laetsch, Theodore W, Widener, Melissa, Rheingold, Susan R, Oesterheld, Javier, Hijiya, Nobuko, Sulis, Maria Luisa, Huynh, Van, Place, Andrew E, Bittencourt, Henrique, Hutchinson, Raymond, Messinger, Yoav, Chang, Bill, Matloub, Yousif, Ziegler, David S, Gardner, Rebecca, Cooper, Todd, Ceppi, Francesco, Hermiston, Michelle, Dalla-Pozza, Luciano, Schultz, Kirk R, Gaynon, Paul, Wayne, Alan S, and Whitlock, James A

Subjects
Childhood Leukemia, Pediatric Research Initiative, Hematology, Orphan Drug, Pediatric, Clinical Research, Rare Diseases, Cancer, Pediatric Cancer, Antineoplastic Agents, B-Lymphocytes, Bone Marrow, Child, Child, Preschool, Disease-Free Survival, Female, Humans, Infant, Male, Neoplasm Recurrence, Local, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Remission Induction, Retrospective Studies, Salvage Therapy, Clinical Sciences, Oncology and Carcinogenesis, Immunology
Abstract

The survival of pediatric patients with multiply relapsed and/or refractory (R/R) B-cell acute lymphoblastic leukemia has historically been very poor; however, data are limited in the current era. We conducted a retrospective study to determine the outcome of multiply R/R childhood B-ALL treated at 24 TACL institutions between 2005 and 2013. Patient information, treatment, and response were collected. Prognostic factors influencing the complete remission (CR) rate and event-free survival (EFS) were analyzed. The analytic set included 578 salvage treatment attempts among 325 patients. CR rates (mean ± SE) were 51 ± 4% for patients with bone marrow R/R B-ALL who underwent a second salvage attempt, 37 ± 6% for a third attempt, and 31 ± 6% for the fourth through eighth attempts combined. For patients achieving a CR after their second, third, and fourth through eighth attempts, the 2 year EFS was 41 ± 6%, 13 ± 7%, and 27 ± 13% respectively. Our results showed slight improvement when compared to previous studies. This is the largest and most recent study to date that evaluates the outcome of this patient population. Our data will provide detailed reference for the evaluation of new agents being developed for childhood B-ALL.

Published
2018

9. Association Between the Magnitude of Intravenous Busulfan Exposure and Development of Hepatic Veno-Occlusive Disease in Children and Young Adults Undergoing Myeloablative Allogeneic Hematopoietic Cell Transplantation

Author

Bognàr, Tim, Bartelink, Imke H., Egberts, Toine C.G., Rademaker, Carin M.A., Versluys, A. Birgitta, Slatter, Mary A., Kletzel, Morris, Nath, Christa E., Cuvelier, Geoffrey D.E, Savic, Rada M., Dvorak, Christopher, Long-Boyle, Janel R., Cowan, Morton J., Bittencourt, Henrique, Bredius, Robbert G.M., Güngör, Tayfun, Shaw, Peter J., Ansari, Marc, Hassan, Moustapha, Krajinovic, Maja, Hempel, Georg, Marktel, Sarah, Chiesa, Robert, Théoret, Yves, Lund, Troy, Orchard, Paul J., Wynn, Robert F., Boelens, Jaap Jan, and Lalmohamed, Arief

Published
2022
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10. GSTM1 and GSTT1 double null genotypes determining cell fate and proliferation as potential risk factors of relapse in children with hematological malignancies after hematopoietic stem cell transplantation

Author

Jurkovic Mlakar, Simona, Uppugunduri, Satyanarayana Chakradhara Rao, Nava, Tiago, Mlakar, Vid, Golay, Hadrien, Robin, Shannon, Waespe, Nicolas, Rezgui, Mohamed Aziz, Chalandon, Yves, Boelens, Jaap Jan, Bredius, Robert G. M., Dalle, Jean-Hugues, Peters, Christina, Corbacioglu, Selim, Bittencourt, Henrique, Krajinovic, Maja, and Ansari, Marc

Published
2022
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11. Whole-transcriptome analysis in acute lymphoblastic leukemia: a report from the DFCI ALL Consortium Protocol 16-001

Author

Tran, Thai Hoa, Langlois, Sylvie, Meloche, Caroline, Caron, Maxime, Saint-Onge, Pascal, Rouette, Alexandre, Bataille, Alain R., Jimenez-Cortes, Camille, Sontag, Thomas, Bittencourt, Henrique, Laverdière, Caroline, Lavallée, Vincent-Philippe, Leclerc, Jean-Marie, Cole, Peter D., Gennarini, Lisa M., Kahn, Justine M., Kelly, Kara M., Michon, Bruno, Santiago, Raoul, Stevenson, Kristen E., Welch, Jennifer J.G., Schroeder, Kaitlin M., Koch, Victoria, Cellot, Sonia, Silverman, Lewis B., and Sinnett, Daniel

Published
2022
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12. Metabolomic identification of α-ketoglutaric acid elevation in pediatric chronic graft-versus-host disease

Author

Subburaj, Divya, Ng, Bernard, Kariminia, Amina, Abdossamadi, Sayeh, Lauener, Madeline, Nemecek, Eneida R., Rozmus, Jacob, Kharbanda, Sandhya, Kitko, Carrie L., Lewis, Victor A., Schechter-Finklestein, Tal, Jacobsohn, David A., Harris, Andrew C., Pulsipher, Michael A., Bittencourt, Henrique, Choi, Sung Won, Caywood, Emi H., Kasow, Kimberly A., Bhatia, Monica, Oshrine, Benjamin R., Coulter, Donald, Chewning, Joseph H., Joyce, Michael, Pawlowska, Anna B., Megason, Gail C., Lawitschka, Anita, Ostroumov, Elena, Klein Geltink, Ramon, Cuvelier, Geoffrey D.E., and Schultz, Kirk R.

Published
2022
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13. The impact of comparative genomic hybridization/single‐nucleotide polymorphism microarray in risk stratification of pediatric acute lymphoblastic leukemia.

Author

Gourmel, Antoine, Perrault, Héloïse, Colaiacovo, Marie‐Laure, Laramée, Louise, Rozendaal, Marieke, Bittencourt, Henrique, Laverdière, Caroline, Champagne, Josette, Cellot, Sonia, Silverman, Lewis B., Lemyre, Emmanuelle, Maftei, Catalina, Mathonnet, Géraldine, Tihy, Frédérique, Pelland‐Marcotte, Marie‐Claude, Léveillé, France, and Tran, Thai Hoa

Published
2024
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14. Cytokine release syndrome after CAR T-cell therapy for B-cell acute lymphoblastic leukemia in children and young adolescents: storms make trees take deeper roots.

Author

Tardif, Magalie, Usmani, Nida, Krajinovic, Maja, and Bittencourt, Henrique

Subjects
CHIMERIC antigen receptors, CYTOKINES, LYMPHOBLASTIC leukemia in children, T cells, TOCILIZUMAB, CORTICOSTEROIDS, CELLULAR immunity
Abstract

Introduction: Chimeric antigen receptor (CAR) T-cells have revolutionized cancer treatment, showing significant success, including treatment of pediatric B-cell acute lymphoblastic leukemia (B-ALL). Despite their efficacy, cytokine release syndrome (CRS) emerges as a common early adverse effect that can be life threatening in severe cases, resulting from the immune system's targeted activation against tumors. Areas covered: This review concentrates on CRS in children and young adults undergoing CAR T-cell therapy for B-ALL. It explores CRS pathophysiology, clinical presentation, and incidence, emphasizing the importance of a consensus definition and grading to homogenize the treatment according to the severity of symptoms. We will discuss the standard of care treatment of CRS but also novel approaches. We will highlight the importance of managing CRS without compromising the efficacy of immune cell activation against tumors. Expert opinion: As CAR T-cell therapy in pediatric B-ALL become increasingly available and used, optimal management of CRS becomes increasingly important. Early recognition and timely management has improved. Further information will aid us to identify optimal timing of tocilizumab and corticosteroids. Continued bench research coupled with clinical studies and biomarker discovery will allow for valuable insights into CRS pathophysiology and patient and/or cell-targeted treatments. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Genetic susceptibility to acute graft versus host disease in pediatric patients undergoing HSCT

Author

Ansari, Marc, Petrykey, Kateryna, Rezgui, Mohamed Aziz, Del Vecchio, Veronica, Cortyl, Jacques, Ameur, Milad, Nava, Tiago, Beaulieu, Patrick, St-Onge, Pascal, Mlakar, Simona Jurkovic, Uppugunduri, Chakradhara Rao S., Théoret, Yves, Bartelink, Imke H., Boelens, Jaap-Jan, Bredius, Robbert G. M., Dalle, Jean-Hugues, Lewis, Victor, Kangarloo, Bill S., Corbacioglu, Selim, Sinnett, Daniel, Bittencourt, Henrique, and Krajinovic, Maja

Published
2021
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18. Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. II: CAR-T cell therapy for patients with CD19+ acute lymphoblastic leukemia

Author

Seber, Adriana, de Castro Junior, Claudio Galvão, Kerbauy, Lucila N., Hirayama, Alexandre V., Bonfim, Carmem, Fernandes, Juliana Folloni, Souza, Mair, Schafell, Rony, Nabhan, Samir, Loggetto, Sandra Regina, Simões, Belinda Pinto, Rocha, Vanderson, de Lima, Marcos, Guerino-Cunha, Renato L., and Bittencourt, Henrique

Published
2021
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21. Association of busulfan exposure with survival and toxicity after haemopoietic cell transplantation in children and young adults: a multicentre, retrospective cohort analysis

Author

Bartelink, Imke H, Lalmohamed, Arief, van Reij, Elisabeth ML, Dvorak, Christopher C, Savic, Rada M, Zwaveling, Juliette, Bredius, Robbert GM, Egberts, Antoine CG, Bierings, Marc, Kletzel, Morris, Shaw, Peter J, Nath, Christa E, Hempel, George, Ansari, Marc, Krajinovic, Maja, Théorêt, Yves, Duval, Michel, Keizer, Ron J, Bittencourt, Henrique, Hassan, Moustapha, Güngör, Tayfun, Wynn, Robert F, Veys, Paul, Cuvelier, Geoff DE, Marktel, Sarah, Chiesa, Robert, Cowan, Morton J, Slatter, Mary A, Stricherz, Melisa K, Jennissen, Cathryn, Long-Boyle, Janel R, and Boelens, Jaap Jan

Subjects
Cancer, Transplantation, Good Health and Well Being, Adolescent, Adult, Area Under Curve, Busulfan, Child, Child, Preschool, Cohort Studies, Disease-Free Survival, Dose-Response Relationship, Drug, Female, Graft Rejection, Graft Survival, Graft vs Host Disease, Hematopoietic Stem Cell Transplantation, Humans, Infant, Male, Recurrence, Retrospective Studies, Transplantation Conditioning, Transplantation, Homologous, Treatment Outcome, Cardiorespiratory Medicine and Haematology, Clinical Sciences
Abstract

BackgroundIntravenous busulfan combined with therapeutic drug monitoring to guide dosing improves outcomes after allogeneic haemopoietic cell transplantation (HCT). The best method to estimate busulfan exposure and optimum exposure in children or young adults remains unclear. We therefore assessed three approaches to estimate intravenous busulfan exposure (expressed as cumulative area under the curve [AUC]) and associated busulfan AUC with clinical outcomes in children or young adults undergoing allogeneic HCT.MethodsIn this retrospective analysis, patients from 15 centres in the Netherlands, USA, Canada, Switzerland, UK, Italy, Germany, and Australia who received a busulfan-based conditioning regimen between March 18, 2001, and Feb 12, 2015, were included. Cumulative AUC was calculated by numerical integration using non-linear mixed effect modelling (AUCNONMEM), non-compartmental analysis (AUC from 0 to infinity [AUC0-∞] and to the next dose [AUC0-τ]), and by individual centres using various approaches (AUCcentre). The main outcome of interest was event-free survival. Other outcomes of interest were graft failure or relapse, or both; transplantation-related mortality; acute toxicity (veno-occlusive disease or acute graft versus-host disease [GvHD]); chronic GvHD; overall survival; and chronic-GvHD-free event-free survival. We used propensity-score-adjusted Cox proportional hazard models, Weibull models, and Fine-Gray competing risk regressions for statistical analyses.Findings790 patients were enrolled, 674 of whom were included: 274 (41%) with malignant and 400 (59%) with non-malignant disease. Median age was 4·5 years (IQR 1·4-10·7). The median busulfan AUCNONMEM was 74·4 mg × h/L (95% CI 31·1-104·6), which correlated with the standardised method AUC0-∞ (r2=0·74), but the latter correlated poorly with AUCcentre (r2=0·35). Estimated 2-year event-free survival was 69·7% (95% CI 66·2-73·0). Event-free survival at 2 years was 77·0% (95% CI 72·1-82·9) in the 257 patients with an optimum intravenous busulfan AUC of 78-101 mg × h/L compared with 66·1% (60·9-71·4) in the 235 patients at the low historical target of 58-86 mg × h/L and 49·5% (29·2-66·0) in the 44 patients with a high (>101 mg × h/L) busulfan AUC (p=0·011). Compared with the low AUC group, graft failure or relapse occurred less frequently in the optimum AUC group (hazard ratio [HR] 0·57, 95% CI 0·39-0·84; p=0·0041). Acute toxicity (HR 1·69, 1·12-2·57; p=0·013) and transplantation-related mortality (2·99, 1·82-4·92; p101 mg × h/L) than in the low AUC group (

Published
2016

22. Genetic Susceptibility to Hepatic Sinusoidal Obstruction Syndrome in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation

Author

Ansari, Marc, Petrykey, Kateryna, Rezgui, Mohamed Aziz, Del Vecchio, Veronica, Cortyl, Jacques, Ralph, Reginald-Olivier, Nava, Tiago, Beaulieu, Patrick, St-Onge, Pascal, Jurkovic Mlakar, Simona, Huezo-Diaz Curtis, Patricia, Uppugunduri, Chakradhara Rao S., Lesne, Laurence, Théoret, Yves, Chalandon, Yves, Bartelink, Imke H., Boelens, Jaap-Jan, Bredius, Robbert G.M., Dalle, Jean-Hugues, Lewis, Victor, Kangarloo, Bill S., Peters, Christina, Sinnett, Daniel, Bittencourt, Henrique, and Krajinovic, Maja

Published
2020
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23. Case report: Success of allogeneic hematopoietic stem cell transplantation for refractory systemic-onset juvenile idiopathic arthritis

Author

Beaufils, Camille, primary, Proulx, Catherine, additional, Blincoe, Annaliesse, additional, Teira, Pierre, additional, Bittencourt, Henrique, additional, Cellot, Sonia, additional, Duval, Michel, additional, Morin, Marie-Paule, additional, De Bruycker, Jean Jacques, additional, Couture, Julie, additional, Samaan, Kathryn, additional, Decaluwe, Hélène, additional, Kleiber, Niina, additional, El-Jalbout, Ramy, additional, Touzot, Fabien, additional, Haddad, Elie, additional, and Barsalou, Julie, additional

Published
2023
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25. Patient-reported quality of life after tisagenlecleucel infusion in children and young adults with relapsed or refractory B-cell acute lymphoblastic leukaemia: a global, single-arm, phase 2 trial

Author

Laetsch, Theodore W, Myers, Gary Douglas, Baruchel, André, Dietz, Andrew C, Pulsipher, Michael A, Bittencourt, Henrique, Buechner, Jochen, De Moerloose, Barbara, Davis, Kara L, Nemecek, Eneida, Driscoll, Timothy, Mechinaud, Francoise, Boissel, Nicolas, Rives, Susana, Bader, Peter, Peters, Christina, Sabnis, Himalee S, Grupp, Stephan A, Yanik, Gregory A, Hiramatsu, Hidefumi, Stefanski, Heather E, Rasouliyan, Lawrence, Yi, Lan, Shah, Sweta, Zhang, Jie, and Harris, Andrew C

Published
2019
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26. Correction to: GSTM1 and GSTT1 double null genotypes determining cell fate and proliferation as potential risk factors of relapse in children with hematological malignancies after hematopoietic stem cell transplantation

Author

Jurkovic Mlakar, Simona, Uppugunduri, Satyanarayana Chakradhara Rao, Nava, Tiago, Mlakar, Vid, Golay, Hadrien, Robin, Shannon, Waespe, Nicolas, Rezgui, Mohamed Aziz, Chalandon, Yves, Boelens, Jaap Jan, Bredius, Robert G. M., Dalle, Jean-Hugues, Peters, Christina, Corbacioglu, Selim, Bittencourt, Henrique, Krajinovic, Maja, and Ansari, Marc

Published
2022
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27. Benefits and challenges with diagnosing chronic and late acute GVHD in children using the NIH consensus criteria

Author

Cuvelier, Geoffrey D.E., Nemecek, Eneida R., Wahlstrom, Justin T., Kitko, Carrie L., Lewis, Victor A., Schechter, Tal, Jacobsohn, David A., Harris, Andrew C., Pulsipher, Michael A., Bittencourt, Henrique, Choi, Sung Won, Caywood, Emi H., Kasow, Kimberly A., Bhatia, Monica, Oshrine, Benjamin R., Flower, Allyson, Chaudhury, Sonali, Coulter, Donald, Chewning, Joseph H., Joyce, Michael, Savaşan, Süreyya, Pawlowska, Anna B., Megason, Gail C., Mitchell, David, Cheerva, Alexandra C., Lawitschka, Anita, West, Lori J., Pan, Bo, Al Hamarneh, Yazid N., Halevy, Anat, and Schultz, Kirk R.

Published
2019
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29. CBFA2T3::GLIS2 Pediatric Acute Megakaryoblastic Leukemia is Sensitive to BCL-XL Inhibition by Navitoclax and DT2216

Author

Gress, Verena, primary, Roussy, Mathieu, additional, Boulianne, Luc, additional, Bilodeau, Mélanie, additional, Cardin, Sophie, additional, EL-Hachem, Nehme, additional, Lisi, Véronique, additional, Khakipoor, Banafsheh, additional, Rouette, Alexandre, additional, Farah, Azer, additional, Théret, Louis, additional, Aubert, Léo, additional, Fatima, Furat, additional, Audemard, Eric, additional, Thibault, Pierre, additional, Bonneil, Éric, additional, Chagraoui, Jalila, additional, Laramée, Louise, additional, Gendron, Patrick, additional, Jouan, Loubna, additional, Jammali, Safa, additional, Paré, Bastien, additional, Simpson, Shawn M., additional, Tran, Thai Hoa, additional, Duval, Michel, additional, Teira, Pierre, additional, Bittencourt, Henrique, additional, Santiago, Raoul, additional, Barabé, Frédéric, additional, Sauvageau, Guy, additional, Smith, Martin A, additional, Hébert, Josée, additional, Roux, Philippe P, additional, Gruber, Tanja A, additional, Lavallée, Vincent-Philippe, additional, Wilhelm, Brian T, additional, and Cellot, Sonia, additional

Published
2023
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30. Low Body Mass Index Is Associated with Increased Risk of Acute GVHD after Umbilical Cord Blood Transplantation in Children and Young Adults with Acute Leukemia: A Study on Behalf of Eurocord and the EBMT Pediatric Disease Working Party

Author

Paviglianiti, Annalisa, Dalle, Jean Hugues, Ayas, Mouhab, Boelens, Jan Jaap, Volt, Fernanda, Iori, Anna Paola, de Souza, Mair Pedro, Diaz, Miguel Angel, Michel, Gerard, Locatelli, Franco, Jubert, Charlotte, Yakoub-Agha, Ibrahim, Bittencourt, Henrique, Bertrand, Yves, Kenzey, Chantal, Tozatto Maio, Karina, Hayashi, Hiromi, Rocha, Vanderson, Bader, Peter, Gluckman, Eliane, and Ruggeri, Annalisa

Published
2018
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36. Factors Associated with Long-Term Risk of Relapse after Unrelated Cord Blood Transplantation in Children with Acute Lymphoblastic Leukemia in Remission

Author

Page, Kristin M., Labopin, Myriam, Ruggeri, Annalisa, Michel, Gerard, Diaz de Heredia, Cristina, O'Brien, Tracey, Picardi, Alessandra, Ayas, Mouhab, Bittencourt, Henrique, Vora, Ajay J., Troy, Jesse, Bonfim, Carmen, Volt, Fernanda, Gluckman, Eliane, Bader, Peter, Kurtzberg, Joanne, and Rocha, Vanderson

Published
2017
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37. Impact of CTLA4 genotype and other immune response gene polymorphisms on outcomes after single umbilical cord blood transplantation

Author

Cunha, Renato, Zago, Marco A., Querol, Sergio, Volt, Fernanda, Ruggeri, Annalisa, Sanz, Guillermo, Pouthier, Fabienne, Kogler, Gesine, Vicario, José L., Bergamaschi, Paola, Saccardi, Riccardo, Lamas, Carmen H., Díaz-de-Heredia, Cristina, Michel, Gerard, Bittencourt, Henrique, Tavella, Marli, Panepucci, Rodrigo A., Fernandes, Francisco, Pavan, Julia, Gluckman, Eliane, and Rocha, Vanderson

Published
2017
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38. Three-Year Update of Tisagenlecleucel in Pediatric and Young Adult Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia in the ELIANA Trial

Author

Laetsch, Theodore W., primary, Maude, Shannon L., additional, Rives, Susana, additional, Hiramatsu, Hidefumi, additional, Bittencourt, Henrique, additional, Bader, Peter, additional, Baruchel, André, additional, Boyer, Michael, additional, De Moerloose, Barbara, additional, Qayed, Muna, additional, Buechner, Jochen, additional, Pulsipher, Michael A., additional, Myers, Gary Douglas, additional, Stefanski, Heather E., additional, Martin, Paul L., additional, Nemecek, Eneida, additional, Peters, Christina, additional, Yanik, Gregory, additional, Khaw, Seong Lin, additional, Davis, Kara L., additional, Krueger, Joerg, additional, Balduzzi, Adriana, additional, Boissel, Nicolas, additional, Tiwari, Ranjan, additional, O'Donovan, Darragh, additional, and Grupp, Stephan A., additional

Published
2023
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41. Seed germination and emergence of Eragrostis tenuifolia (A. Rich.) Hochst. ex Steud. in response to environmental factors

Author

Hertwig Bittencourt Henrique von, Silva Bonome Lisandro Tomas da, Bortoli Pagnoncelli Fortunato de, Lana Marcos Alberto, and Trezzi Michelangelo Muzell

Subjects
burial depth, Eragrostis tenuifolia, irradiance, temperature, weed biology, weed ecology, weed establishment, Plant culture, SB1-1110
Abstract

Eragrostis tenuifolia is a weed species that is gaining ground in Brazil. This weed occurs in pastures, grasslands, crop fields, and roadsides. The objective of this study was to examine the effects of different environmental factors on E. tenuifolia seed germination and seedling emergence. The optimum constant temperature for germination was around 35-30°C. It was also found that 85% of seeds germinated under a 30/20°C alternate temperature regime. Light appears to have a positive effect on seed germination. No seedlings emerged when seeds were buried 3 cm or deeper. The results suggested that E. tenuifolia has the potential to spread into pastures and in no-tillage crop systems in Brazil. Measures such as the use of cover crops and/or soil cultivation can be used to limit germination and seedling emergence, respectively.

Published
2016
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42. Clinical response to dabrafenib and chemotherapy in clonally-related histiocytosis and acute lymphoblastic leukemia

Author

Hubert, Gervaise, primary, Bittencourt, Henrique, additional, Laverdière, Caroline, additional, Teira, Pierre, additional, Cellot, Sonia, additional, Langlois, Sylvie, additional, Rouette, Alexandre, additional, Sontag, Thomas, additional, Sinnett, Daniel, additional, Dal-Soglio, Dorothée, additional, Turpin, Sophie, additional, and Tran, Thai Hoa, additional

Published
2022
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43. Ruxolitinib in Pediatric Patients with Treatment-Naïve or Steroid-Refractory Acute Graft-Versus-Host Disease: Primary Findings from the Phase I/II REACH4 Study

Author

Locatelli, Franco, primary, Kang, Hyoung Jin, additional, Bruno, Bénédicte, additional, Gandemer, Virginie, additional, Rialland, Fanny, additional, Faraci, Maura, additional, Takahashi, Yoshiyuki, additional, Koh, Katsuyoshi, additional, Bittencourt, Henrique, additional, Cleary, Grace, additional, Rosko, Christine, additional, Roussou, Pantelia, additional, St. Pierre, Annie, additional, Prahallad, Anirudh, additional, and Díaz-de-Heredia, Cristina, additional

Published
2022
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44. A diagnostic classifier for pediatric chronic graft-versus-host disease: results of the ABLE / PBMTC 1202 study

Author

Cuvelier, Geoffrey D.E., primary, Ng, Bernard, additional, Abdossamadi, Sayeh, additional, Nemecek, Eneida R., additional, Melton, Alexis, additional, Kitko, Carrie L., additional, Lewis, Victor Anthony, additional, Schechter, Tal, additional, Jacobsohn, David A, additional, Harris, Andrew C., additional, Pulsipher, Michael A, additional, Bittencourt, Henrique, additional, Choi, Sung Won, additional, Caywood, Emi H, additional, Kasow, Kimberly A., additional, Bhatia, Monica, additional, Oshrine, Benjamin R, additional, Chaudhury, Sonali, additional, Coulter, Donald, additional, Chewning, Joseph H, additional, Joyce, Michael, additional, Savaşan, Süreyya, additional, Pawlowska, Anna B, additional, Megason, Gail C, additional, Mitchell, David, additional, Cheerva, Alexandra C, additional, Lawitschka, Anita, additional, Ostroumov, Elena, additional, and Schultz, Kirk R, additional

Published
2022
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46. Morfogenia y rendimiento forrajero de la avena blanca (Avena sativa) bajo fuentes y niveles de fósforo

Author

Pereira, Luan Carlos de Almeida, Dias, Juliano Cesar, and Bittencourt, Henrique von Hertwig

Subjects
Fosfato natural reativo, Reactive natural phosphate, Superfosfato simple, Forrageira de inverno, Winter forage, Adubação fosfatada, Forraje de invierno, Phosphate fertilization, Fosfato natural reactivo, Simple superphosphate, Fertilización fosfatada, Superfosfato simples
Abstract

The objective was to evaluate the morphology and forage yield of white oat cultivated under different doses and sources of phosphate fertilization. The experimental design used was completely randomized in a 4x2 factorial scheme, with five replications. The treatments were four doses of phosphorus: 0, 35, 70 and 140 kg ha-1 of P2O5, and two sources of phosphorus: simple superphosphate (18% of P2O5) and reactive natural phosphate (33% of P2O5). There was an effect (p

Published
2022

47. Los atributos fisicoquímicos del suelo son influenciados por el tipo de manejo del campo nativo

Author

Proner Júnior, Luigildo, Bittencourt, Henrique von Hertwig, Dias, Juliano Cesar, Grillo, José Francisco, and Bonome, Lisandro Tomas da Silva

Subjects
Pastagem natural, Natural grassland, Sobressemeadura, Siega, Pasto natural, Roçada, Mowing, Resiembra, Fogo, Overseeding, Fuego, Fire
Abstract

The objective of the present work was to evaluate the influence of different pasture management strategies in a grassland on the physicochemical characteristics of the soil. For that, a field experiment was carried out, testing overseeding, mowing, use of fire and absence of management in a randomized block design with four replications. A higher level of soil compaction was recorded in the treatments with fire and mowing compared to the absence of management and overseeding. All treatments increased soil organic matter contents, with the greatest variation occurring in the mowing and the smallest in the fire. The H+Al contents increased in all treatments with the greatest variation occurring in the absence of management and the smallest in the mowing and fire. Potassium content decreased only in overseeding and increased more significantly in fire. Phosphorus content increased in overseeding and more significantly in fire. Base saturation decreased in all treatments, more significantly in overseeding and in the absence of management. The results show changes in important parameters for the agricultural use of grassland soil, suggesting that, in general, the use of overseeding and mowing practices present a more favorable change potential than the absence of management or use of fire. El objetivo del presente trabajo fue evaluar la influencia de diferentes estrategias de manejo de pastos en pastizal nativo sobre las características fisicoquímicas del suelo. Para ello, se realizó un experimento de campo, ensayando resiembra, siega, uso de fuego y ausencia de manejo en un diseño de bloques al azar con cuatro repeticiones. Se registró un mayor nivel de compactación del suelo en los tratamientos con fuego y siega frente a la ausencia de manejo y resiembra. Todos los tratamientos incrementaron los contenidos de materia orgánica del suelo, ocurriendo la mayor variación en la siega y la menor en el fuego. Los contenidos de H+Al aumentaron en todos los tratamientos ocurriendo la mayor variación en ausencia de manejo y la menor en la siega y fuego. El contenido de potasio disminuyó solo en la resiembra y aumentó más significativamente en el fuego. El contenido de fósforo aumentó en la resiembra y más significativamente en el fuego. La saturación de bases disminuyó en todos los tratamientos, más significativamente en resiembra y en ausencia de manejo. Los resultados muestran cambios en parámetros importantes para el uso agrícola del suelo de pastizales nativos, sugiriendo que, en general, el uso de prácticas de resiembra y siega presentan un potencial de cambio más favorable que la ausencia de manejo o uso del fuego. O objetivo do presente trabalho foi avaliar a influência de diferentes estratégias de manejo da pastagem em campo nativo sobre características físico-químicas do solo. Para tanto foi realizado um experimento a campo testando sobressemeadura, roçada, uso de fogo e ausência de manejo em delineamento de blocos casualizados com quatro repetições. Maior nível de compactação do solo foi registrado nos tratamentos com uso de fogo e roçada em comparação a ausência de manejo e a sobressemeadura. Todos os tratamentos aumentaram os teores de matéria orgânica do solo, com a maior variação ocorrendo na roçada e a menor no fogo. Os teores de H+Al aumentaram em todos os tratamentos com a maior variação ocorrendo na ausência de manejo e a menor na roçada e fogo. O teor de potássio diminuiu apenas na sobressemeadura e aumentou mais expressivamente no fogo. O teor de fósforo aumentou na sobresemeadura e mais expressivamente no fogo. A saturação de bases diminuiu em todos os tratamentos, mais expressivamente na sobressemeadura e na ausência de manejo. Os resultados apresentam modificações de parâmetros importantes para o uso agropecuário dos solo de campo nativo, sugerindo que de maneira geral, a utilização de práticas de sobresemeadura e roçada apresentam potencial de alteração mais favorável que ausência de manejo ou uso do fogo.

Published
2022

48. Prognostic factors and outcomes of infant acute lymphoblastic leukemia (ALL), hypodiploid ALL, and mixed-phenotype acute leukemia (MPAL) in Canada: a report from CYP-C

Author

Tibout, Pauline, primary, Ledjiar, Omar, additional, Athale, Uma, additional, Rayar, Meera, additional, Kulkarni, Ketan, additional, Truong, Tony, additional, Cellot, Sonia, additional, Bittencourt, Henrique, additional, Pelland-Marcotte, Marie-Claude, additional, and Tran, Thai Hoa, additional

Published
2022
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