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3. Additional file 4 of Prognostic value of immune factors in the tumor microenvironment of patients with pancreatic ductal adenocarcinoma

Author

Kiryu, Sachie, Ito, Zensho, Suka, Machi, Bito, Tsuuse, Kan, Shin, Uchiyama, Kan, Saruta, Masayuki, Hata, Taigo, Takano, Yuki, Fujioka, Shuichi, Misawa, Takeyuki, Yamauchi, Takashi, Yanagisawa, Hiroyuki, Sato, Nobuhiro, Ohkusa, Toshifumi, Sugiyama, Haruo, and Koido, Shigeo

Subjects
animal diseases, bacteria, chemical and pharmacologic phenomena, biochemical phenomena, metabolism, and nutrition
Abstract

Additional file 4. Table S4. Association of clinicopathological characteristics with immune related cells

Published
2021
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4. Additional file 8 of Prognostic value of immune factors in the tumor microenvironment of patients with pancreatic ductal adenocarcinoma

Author

Kiryu, Sachie, Ito, Zensho, Suka, Machi, Bito, Tsuuse, Kan, Shin, Uchiyama, Kan, Saruta, Masayuki, Hata, Taigo, Takano, Yuki, Fujioka, Shuichi, Misawa, Takeyuki, Yamauchi, Takashi, Yanagisawa, Hiroyuki, Sato, Nobuhiro, Ohkusa, Toshifumi, Sugiyama, Haruo, and Koido, Shigeo

Abstract

Additional file 8 Fig. S1. Associations of PD-1+ cells in tertiary lymphoid aggregates with clinical prognosis

Published
2021
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5. Additional file 3 of Prognostic value of immune factors in the tumor microenvironment of patients with pancreatic ductal adenocarcinoma

Author

Kiryu, Sachie, Ito, Zensho, Suka, Machi, Bito, Tsuuse, Kan, Shin, Uchiyama, Kan, Saruta, Masayuki, Hata, Taigo, Takano, Yuki, Fujioka, Shuichi, Misawa, Takeyuki, Yamauchi, Takashi, Yanagisawa, Hiroyuki, Sato, Nobuhiro, Ohkusa, Toshifumi, Sugiyama, Haruo, and Koido, Shigeo

Abstract

Additional file 3. Table S3. Univariate and multivariate analysis for disease free survival

Published
2021
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6. Additional file 1 of Prognostic value of immune factors in the tumor microenvironment of patients with pancreatic ductal adenocarcinoma

Author

Kiryu, Sachie, Ito, Zensho, Suka, Machi, Bito, Tsuuse, Kan, Shin, Uchiyama, Kan, Saruta, Masayuki, Hata, Taigo, Takano, Yuki, Fujioka, Shuichi, Misawa, Takeyuki, Yamauchi, Takashi, Yanagisawa, Hiroyuki, Sato, Nobuhiro, Ohkusa, Toshifumi, Sugiyama, Haruo, and Koido, Shigeo

Abstract

Additional file 1. Table S1. Base line characteristics of laboratory data and systemic inflammatory responses

Published
2021
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7. Additional file 9 of Prognostic value of immune factors in the tumor microenvironment of patients with pancreatic ductal adenocarcinoma

Author

Kiryu, Sachie, Ito, Zensho, Suka, Machi, Bito, Tsuuse, Kan, Shin, Uchiyama, Kan, Saruta, Masayuki, Hata, Taigo, Takano, Yuki, Fujioka, Shuichi, Misawa, Takeyuki, Yamauchi, Takashi, Yanagisawa, Hiroyuki, Sato, Nobuhiro, Ohkusa, Toshifumi, Sugiyama, Haruo, and Koido, Shigeo

Subjects
endocrine system diseases, sense organs, digestive system diseases
Abstract

Additional file 9 Fig. S2. Associations of Foxp3+ cells in the PDAC TME with clinical prognosis

Published
2021
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8. Additional file 6 of Prognostic value of immune factors in the tumor microenvironment of patients with pancreatic ductal adenocarcinoma

Author

Kiryu, Sachie, Ito, Zensho, Suka, Machi, Bito, Tsuuse, Kan, Shin, Uchiyama, Kan, Saruta, Masayuki, Hata, Taigo, Takano, Yuki, Fujioka, Shuichi, Misawa, Takeyuki, Yamauchi, Takashi, Yanagisawa, Hiroyuki, Sato, Nobuhiro, Ohkusa, Toshifumi, Sugiyama, Haruo, and Koido, Shigeo

Subjects
endocrine system diseases, digestive system diseases
Abstract

Additional file 6. Table S6. Association of immune-related cells with clinical prognosis in PDAC patients with stage I/II disease

Published
2021
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9. Additional file 7 of Prognostic value of immune factors in the tumor microenvironment of patients with pancreatic ductal adenocarcinoma

Author

Kiryu, Sachie, Ito, Zensho, Suka, Machi, Bito, Tsuuse, Kan, Shin, Uchiyama, Kan, Saruta, Masayuki, Hata, Taigo, Takano, Yuki, Fujioka, Shuichi, Misawa, Takeyuki, Yamauchi, Takashi, Yanagisawa, Hiroyuki, Sato, Nobuhiro, Ohkusa, Toshifumi, Sugiyama, Haruo, and Koido, Shigeo

Subjects
endocrine system diseases, digestive system diseases
Abstract

Additional file 7. Table S7. Association of immune-related cells with clinical prognosis in PDAC patients with stage III disease

Published
2021
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10. Additional file 5 of Prognostic value of immune factors in the tumor microenvironment of patients with pancreatic ductal adenocarcinoma

Author

Kiryu, Sachie, Ito, Zensho, Suka, Machi, Bito, Tsuuse, Kan, Shin, Uchiyama, Kan, Saruta, Masayuki, Hata, Taigo, Takano, Yuki, Fujioka, Shuichi, Misawa, Takeyuki, Yamauchi, Takashi, Yanagisawa, Hiroyuki, Sato, Nobuhiro, Ohkusa, Toshifumi, Sugiyama, Haruo, and Koido, Shigeo

Subjects
animal diseases, bacteria, chemical and pharmacologic phenomena, biochemical phenomena, metabolism, and nutrition
Abstract

Additional file 5. Table S5. Association of laboratory parameters with immune related cells

Published
2021
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12. Clinical Significance of Tumor-Infiltrating T Cells and Programed Death Ligand-1 in Patients with Pancreatic Cancer

Author

Yoshida, Sayumi, primary, Ito, Zensho, additional, Suka, Machi, additional, Bito, Tsuuse, additional, Kan, Shin, additional, Akasu, Takafumi, additional, Saruta, Masayuki, additional, Okamoto, Masato, additional, Kitamura, Hiroaki, additional, Fujioka, Shuichi, additional, Misawa, Takeyuki, additional, Akiba, Tadashi, additional, Yanagisawa, Hiroyuki, additional, Sugiyama, Haruo, additional, and Koido, Shigeo, additional

Published
2019
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13. Predicted Markers of Overall Survival in Pancreatic Cancer Patients Receiving Dendritic Cell Vaccinations Targeting WT1.

Author

Ito, Zensho, Kan, Shin, Bito, Tsuuse, Horiuchi, Sankichi, Akasu, Takafumi, Yoshida, Sayumi, Kajihara, Mikio, Hokari, Atsushi, Saruta, Masayuki, Yoshida, Noriyuki, Kobayashi, Masanori, Ohkusa, Toshifumi, Shimodaira, Shigetaka, Okamoto, Masato, Sugiyama, Haruo, and Koido, Shigeo

Subjects
THERAPEUTIC use of antimetabolites, ADENOCARCINOMA, BIOMARKERS, CANCER chemotherapy, CANCER patients, CLINICAL trials, DENDRITIC cells, GRANULOCYTES, NEPHROBLASTOMA, PANCREATIC tumors, SURVIVAL, TUMOR markers, CANCER vaccines, MATRIX metalloproteinases
Abstract

Background: We have developed a Wilms' tumor 1 (WT1)-targeting dendritic cell (DC)-based cancer vaccine combined with standard chemotherapy for patients with advanced pancreatic ductal adenocarcinoma (PDA). Methods: We evaluated predictive markers of overall survival (OS) in PDA patients treated with multiple major histocompatibility complex class I/II-restricted, WT1 peptide-pulsed DC vaccinations (DC/WT1-I/II) in combination with chemotherapy. Throughout the entire period of immunochemotherapy, the plasma levels of soluble factors derived from granulocytes of 7 eligible PDA patients were examined. Moreover, systemic inflammatory response markers (neutrophil-to-lymphocyte ratio [NLR], monocyte-to-lymphocyte ratio [MLR], and granulocyte-to-lymphocyte ratio [GLR]) were assessed. In addition, cytoplasmic WT1 expression in PDA cells was examined. Results: Compared to the 4 non-super-responders (OS <1 year), the remaining 3 super-responders (OS ≥1 year) showed significantly decreased low plasma matrix metalloproteinase-9 levels throughout long-term therapy. The NLR, MLR, and GLR after 5 DC/WT1-I/II vaccinations and 3 cycles of gemcitabine were significantly lower in the super-responders than in the non-super-responders. Furthermore, the cytoplasmic WT1 expression in the PDA cells of super-responders was relatively weak compared to that in the PDA cells of non-super-responders. Conclusions: Prolonged low levels of a granulocyte-related systemic inflammatory response after the early period of therapy and low cytoplasmic WT1 expression in PDA cells may be markers predictive of OS in PDA patients receiving WT1-targeting immunochemotherapy. [ABSTRACT FROM AUTHOR]

Published
2019
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