41 results on '"Biti GP"'
Search Results
2. Radioterapia
- Author
-
MAURIZI ENRICI, Riccardo and Biti, Gp
- Published
- 2009
3. The Istituto Toscano Tumori (ITT) and the radiotherapy Centers
- Author
-
Chiavacci, A, Biti, Gp, Bosio, M, Casamassima, F, Cionini, L, Mignogna, M, Pirtoli, Luigi, Ponticelli, P, Tagliagambe, A, Tucci, E, Cellai, E, and Amunni, G.
- Published
- 2008
4. Comparison of the conventional 'box' technique with two different 'conformal' beam arrangements for prostate cancer treatment
- Author
-
Magrini, Stefano Maria, Cellai, E, Pertici, M, Compagnucci, A, and Biti, Gp
- Published
- 1999
5. SU-FF-T-615: Multicenter Intercomparison for Treatment of the Mesothelioma with IMRT and Tomotherapy
- Author
-
Guidi, G, primary, Amadori, M, additional, Antognoni, P, additional, Tonoli, S, additional, Spiazzi, L, additional, Ghedi, B, additional, Buonamici, F Banci, additional, Schwarz, M, additional, Danielli, C, additional, Amichetti, M, additional, Biti, GP, additional, Magrini, SM, additional, and Bertoni, F, additional
- Published
- 2009
- Full Text
- View/download PDF
6. Long term nervous system damage from radiation of the spinal cord: an electrophysiological study
- Author
-
DE SCISCIOLO, G, Bartelli, M, Magrini, Stefano Maria, Biti, Gp, Guidi, L, and Pinto, F.
- Published
- 1991
7. Neurological damage in patients irradiated twice on the spinal cord: a morphologic and electrophysiologic study
- Author
-
Magrini, Stefano Maria, Biti, Gp, DE SCISCIOLO, G, Bartelli, M, Pinto, F, Caramella, D, and Villari, N.
- Published
- 1990
8. MOPP CHEMOTHERAPY VERSUS EXTENDED-FIELD RADIOTHERAPY IN THE MANAGEMENT OF PATHOLOGICAL STAGES I-IIA HODGKINS-DISEASE
- Author
-
Cimino, G., Biti, Gp, Anselmo, Ap, Enrici, Rm, Bellesi, Gp, Bosi, A., Cionini, L, Mungai, V, Papa, G, Ponticelli, P, Tombolini, Vincenzo, Ferrini, Plr, Biagin, C, and MANDELLI F
- Subjects
Adult ,Male ,Adolescent, Adult, Antineoplastic Combined Chemotherapy Protocols ,therapeutic use, Combined Modality Therapy, Female, Hodgkin Disease ,drug therapy/radiotherapy, Humans, Male, Mechlorethamine ,administration /&/ dosage/adverse effects, Middle Aged, Prednisone ,administration /&/ dosage/adverse effects, Procarbazine ,administration /&/ dosage/adverse effects, Random Allocation, Vincristine ,administration /&/ dosage/adverse effects ,Adolescent ,Middle Aged ,Combined Modality Therapy ,Hodgkin Disease ,drug therapy/radiotherapy ,Random Allocation ,Vincristine ,therapeutic use ,Procarbazine ,Antineoplastic Combined Chemotherapy Protocols ,Humans ,Prednisone ,Female ,Mechlorethamine - Published
- 1989
9. Tubular carcinoma of the breast: Outcome and loco-regional recurrence in 307 patients
- Author
-
Beatrice Detti, Fabiola Paiar, Simonetta Bianchi, Elisa Meldolesi, G. Cardona, Lorenzo Livi, Gabriele Simontacchi, Cinzia Talamonti, Sergio Salerno, Giampaolo Biti, LIVI L, F PAIAR, MELDOLESI E, TALAMONTI C, SIMONTACCHI G, DETTI B, SALERNO S, BIANCHI S, CARDONA G, and BITI GP
- Subjects
medicine.medical_treatment ,Disease ,Segmental ,Mastectomy, Segmental ,Breast cancer ,Ductal ,Breast-conserving surgery ,80 and over ,Breast ,Adjuvant ,Mastectomy ,Aged, 80 and over ,Carcinoma, Ductal, Breast ,Tubular carcinoma ,General Medicine ,Middle Aged ,Combined Modality Therapy ,Treatment Outcome ,Radiotherapy ,Adenocarcinoma ,Adult ,Aged ,Antineoplastic Agents, Hormonal ,Axilla ,Breast Neoplasms ,Chemotherapy, Adjuvant ,Female ,Humans ,Lymphatic Metastasis ,Neoplasm Recurrence, Local ,Proportional Hazards Models ,Radiotherapy, Adjuvant ,Survival Analysis ,Tamoxifen ,Oncology ,Surgery ,Local ,medicine.drug ,medicine.medical_specialty ,Antineoplastic Agents ,medicine ,Chemotherapy ,Hormonal ,business.industry ,Carcinoma ,medicine.disease ,Radiation therapy ,Neoplasm Recurrence ,business - Abstract
Purpose The aim of this study is to describe the University of Florence experience in evaluating clinical, pathologic and treatment factors as they are related to the outcome and loco-regional recurrence in patients with tubular breast carcinoma. Material and methods Three hundred and seven patients (median age 56.4 years, range 26–91 years) with histological verified tubular carcinoma of the breast were consecutively treated at University of Florence from 1976 to 2001. All patients were followed for a median of 8.4 years (range 3 months to 20 years). Thirty-seven women underwent mastectomy and 270 underwent breast conserving surgery. Positive axillary nodes were found in 15% of patients. Fifty-two patients did not undergo radiotherapy to whole breast after having breast conserving surgery. Tamoxifen was prescribed in 108 patients and chemotherapy in 21 patients, 15 out of 21 had positive axillary nodes. Results Cause specific survival was 99.6, 99.2 and 97.2% at 3, 5 and 10 years. Local recurrence rate was 1.9, 3.6 and 4.7% at 3, 5 and 10 years. Univariate statistical analysis was significant for specific survival and local recurrence for angiolymphatic invasion only ( p =0.0004). Conclusions In the absence of axillary disease and angiolymphatic invasion, conserving surgery with adjuvant radiotherapy is effective treatment of disease.
- Published
- 2005
10. Impact of a breathing-control system on target margins and normal-tissue sparing in the treatment of lung cancer: experience at the radiotherapy unit of Florence University.
- Author
-
Scotti V, Marrazzo L, Saieva C, Agresti B, Meattini I, Desideri I, Cecchini S, Bertocci S, Franzese C, De Luca Cardillo C, Zei G, Loi M, Greto D, Mangoni M, Bonomo P, Livi L, and Biti GP
- Subjects
- Aged, Aged, 80 and over, Female, Humans, Italy, Lung Neoplasms diagnostic imaging, Male, Middle Aged, Radiotherapy Dosage, Tomography, X-Ray Computed, Treatment Outcome, Tumor Burden, Lung Neoplasms radiotherapy, Movement, Radiotherapy, Conformal, Respiration
- Abstract
Purpose: In lung cancer, a high radiation dose to the target area correlates with better local control but is frequently counterbalanced by a higher risk of lung toxicity. Several methods exist to coordinate respiratory motion in lung radiotherapy. We aimed to investigate the impact of a breathing-control system on irradiated volumes and dosimetric parameters in three-dimensional conformal radiotherapy (3D-CRT) and stereotactic radiotherapy (SRT) treatments., Materials and Methods: Twelve patients were scheduled for radical radiotherapy: five for SRT and seven for 3D-CRT. For each patient, in addition to the free-breathing computed tomography (CT) scan, four additional sets of CT slices were acquired using the Active Breathing Coordinator device (ABC, Elekta Oncology Systems Ltd., UK)., Results: The volumes acquired with the ABC device were significantly smaller than the free-breathing volumes [23 % reduction of planning tumour volume (PTV), p = 0.002]. ABC allowed a reduction of all dosimetric parameters [2.28 % reduction of percentage volume of lung treated to a dose of ≥ 20 Gy (V20), p = 0.004; 10 % reduction of mean lung dose (MLD), p = 0.009]. Significant differences were found both in SRT and in 3D-CRT, in peripheral and apical lesions., Conclusion: In our experience, ABC has the potential to reduce lung toxicity in the treatment of lung cancer; alternatively, it can allow the prescribed dose to be increased while maintaining the same risk of lung toxicity.
- Published
- 2014
- Full Text
- View/download PDF
11. Doxorubicin and cyclophosphamide versus cyclophosphamide, methotrexate, and 5-fluorouracil as adjuvant chemotherapy in breast cancer.
- Author
-
Livi L, Saieva C, Borghesi S, De Luca Cardillo C, Scotti V, Mangoni M, Greto D, Cataliotti L, Paiar F, Bianchi S, and Biti GP
- Subjects
- Breast Neoplasms mortality, Breast Neoplasms pathology, Carcinoma, Ductal, Breast mortality, Carcinoma, Ductal, Breast secondary, Carcinoma, Lobular mortality, Carcinoma, Lobular secondary, Chemotherapy, Adjuvant, Combined Modality Therapy, Cyclophosphamide administration & dosage, Cyclophosphamide therapeutic use, Doxorubicin administration & dosage, Female, Fluorouracil therapeutic use, Humans, Lymphatic Metastasis, Methotrexate therapeutic use, Middle Aged, Neoplasm Staging, Prognosis, Retrospective Studies, Survival Rate, Treatment Outcome, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Breast Neoplasms drug therapy, Carcinoma, Ductal, Breast drug therapy, Carcinoma, Lobular drug therapy
- Abstract
This study evaluated whether doxorubicin and cyclophosphamide are superior to cyclophosphamide, methotrexate and 5-fluorouracil as adjuvant chemotherapy in breast cancer patients. Between July 1976 and December 2004, 1045 breast cancer patients received adjuvant chemotherapy at the Radiotherapy Unit of the University of florence. 927 were administered i.v. CMF (cyclophosphamide 600 mg/m(2), methotrexate 40 mg/m(2) and 5-fluorouracil 600 mg/m(2) on days 1 and 8, repeated every 28 days for a total of six cycles) and 118 i.v. DC (doxorubicin 60 mg/m(2) and cyclophosphamide 600 mg/m(2) on day 1 repeated every 21 days for a total of four cycles). All patients underwent adjuvant radiotherapy as well. The survival analysis, stratified according to treatment, did not show any significant difference in metastasis occurrence between the two groups (log rank test p=0.42). According to multivariate analysis four parameters emerged as independent prognostic factors for distant metastases in patients treated with the Cmf regimen: pt (p=0.0005), number of positive axillary lymph nodes (p=<0.0001), tamoxifen use (p=0.0109) and local relapses (p=<0.0001). Only number of positive axillary lymph nodes and local relapses were significant predictors of metastases occurrence according to multivariate analysis in the DC group, 17 and p=0.028, respectively. No significant difference between the two regimens was observed with regards to number of involved nodes. DC and CMF produced similar outcome in breast cancer patients.
- Published
- 2009
- Full Text
- View/download PDF
12. Concurrent cyclophosphamide, methotrexate, and 5-fluorouracil chemotherapy and radiotherapy for early breast carcinoma.
- Author
-
Livi L, Saieva C, Borghesi S, Paoletti L, Meattini I, Rampini A, Petrucci A, Scoccianti S, Paiar F, Cataliotti L, Leonulli BG, Bianchi S, and Biti GP
- Subjects
- Adult, Aged, Comorbidity, Cyclophosphamide administration & dosage, Female, Fluorouracil administration & dosage, Humans, Incidence, Italy epidemiology, Methotrexate administration & dosage, Middle Aged, Risk Factors, Treatment Outcome, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Breast Neoplasms epidemiology, Breast Neoplasms radiotherapy, Neoplasm Recurrence, Local epidemiology, Neoplasm Recurrence, Local prevention & control, Radiation Injuries epidemiology, Radiotherapy, Adjuvant statistics & numerical data, Risk Assessment methods
- Abstract
Purpose: The optimal sequencing of adjuvant chemotherapy (CT) and radiation therapy (RT) in patients with early-stage breast cancer remains unclear., Patients and Methods: We retrospectively compared 485 patients treated with conservative breast surgery and postoperative whole-breast RT and six courses of CMF (cyclophosphamide 600 mg/m(2), methotrexate 40 mg/m(2), and 5-fluorouracil 600 mg/m(2)) with 300 patients who received postoperative CMF only and with 509 patients treated with postoperative whole-breast RT only. The mean radiation dose delivered was 50 Gy (range, 46-52 Gy) with standard fractionation. The boost dose was 6-16 Gy according to resection margins and at the discretion of the radiation oncologist. Acute and late RT toxicity were scored using respectively the Radiation Therapy Oncology Group and the Late Effects in Normal Tissues Subjective, Objective, Management and Analytic scale., Results: A slightly higher Grade 2 acute skin toxicity was recorded in the concurrent group (21.2% vs. 11.2% of the RT only group, p < 0.0001). RT was interrupted more frequently in the CMF/RT group respective to the RT group (8.5% vs. 4.1%; p = 0.006). There was no difference in late toxicity between the two groups. All patients in the concurrent group successfully received the planned dose of RT and CT. Local recurrence rate was 7.6% in CT/RT group and 9.8% in RT group; this difference was not statistically significant at univariate analysis (log-rank test p = 0.98). However, at multivariate analysis adjusted also for pathological tumor, pathological nodes, and age, the CT/RT group showed a statistically lower rate of local recurrence (p = 0.04)., Conclusions: Whole-breast RT and concurrent CMF are a safe adjuvant treatment in terms of toxicity.
- Published
- 2008
- Full Text
- View/download PDF
13. Loco-regional recurrence in 2064 patients with breast cancer treated with mastectomy without adjuvant radiotherapy.
- Author
-
Livi L, Saieva C, Detti B, Meattini I, Susini T, Paiar F, Mileo A, Rampini A, Bruni A, Petrucci A, and Biti GP
- Subjects
- Adult, Aged, Aged, 80 and over, Antineoplastic Agents therapeutic use, Axilla surgery, Breast Neoplasms drug therapy, Chemotherapy, Adjuvant, Female, Humans, Incidence, Lymph Node Excision, Mastectomy, Middle Aged, Neoplasm Staging, Retrospective Studies, Treatment Outcome, Breast Neoplasms surgery, Neoplasm Recurrence, Local epidemiology, Neoplasm Recurrence, Local pathology
- Abstract
Introduction: We investigated the incidence of loco-regional recurrence in a sub-group of patients who underwent mastectomy without adjuvant radiotherapy to evaluate the effect of each specific clinical or pathological parameter that could be associated with a higher local relapse rate., Patients and Methods: Two thousand and sixty-four patients were treated from January 1971 to December 2003 at the University of Florence., Results: At the time of analysis 18.3% of patients (378/2064) had isolated loco-regional failures. Univariate analysis showed an association of borderline statistical significance with pathological tumour size. Elderly age at diagnosis had a low incidence of local recurrence but the results did not reach statistical significant. The number of positive axillary lymph node did not show any influence for local recurrence., Conclusion: In our series we noted a higher relapse rate only related to the pathological tumour size without any correlation with number of positive axillary nodes. Radiotherapy after mastectomy still remains controversial, but in our series the number of positive axillary lymph node did not seem enough to justify adjuvant treatment.
- Published
- 2007
- Full Text
- View/download PDF
14. [Organ-confined prostate cancer: treatment with high doses of radioterapy (intensity modulated radiotherapy)].
- Author
-
Livi L, Detti B, Meattini M, Sánchez LJ, and Biti GP
- Subjects
- Adenocarcinoma pathology, Aged, Aged, 80 and over, Feasibility Studies, Gastrointestinal Diseases epidemiology, Gastrointestinal Diseases etiology, Humans, Male, Middle Aged, Prostatic Neoplasms pathology, Radiation Injuries epidemiology, Radiation Injuries etiology, Radiotherapy Dosage, Rectum radiation effects, Retrospective Studies, Urinary Bladder radiation effects, Urination Disorders epidemiology, Urination Disorders etiology, Adenocarcinoma radiotherapy, Prostatic Neoplasms radiotherapy, Radiotherapy, Intensity-Modulated adverse effects, Radiotherapy, Intensity-Modulated methods
- Abstract
Purpose: To report toxicity and local control in patients with localized prostate cancer, treated with high dose radiotherapy., Materials and Methods: The records of 100 consecutive patients with clinically localized prostate cancer treated between june 2003 and may 2006 were reviewed. They received 80 Gy to the target volume with a biphasic technique (3DCRT + IMRT). The median pretreatment PSA was 9. The median follow-up time was 12 months., Results: Eighteen (18%) developed acute Grade 2 rectal toxicity, and no patient experienced acute grade 3 or higher rectal symptoms. Forty-four (44%) developed acute Grade 2 urinary symptoms while 34% of the patients experienced no GU symptoms (Grade 0) during treatment. Three patients (3%) developed late rectal toxicity grade 2 and eight patients (8%) experienced late urinary toxicity grade 2; any patients experienced more severe symptoms. We recorded biochemical relapse in two patients, both had poor prognostic factors at initial diagnosis of prostate cancer., Conclusions: The data demonstrate the feasibility and safety of high dose radiotherapy for patients with localized prostate cancer and provide a proof that this method allow safe dose escalation with low severe toxicities to the normal tissues.
- Published
- 2007
- Full Text
- View/download PDF
15. Use of tamoxifen in pT1a-pT1b, pN0 breast cancer.
- Author
-
Livi L, Saieva C, Paiar F, Simontacchi G, Galardi A, De Luca Cardillo C, Mangoni M, Paoletti L, Ponticelli P, and Biti GP
- Subjects
- Adult, Aged, Breast Neoplasms pathology, Breast Neoplasms radiotherapy, Breast Neoplasms surgery, Combined Modality Therapy, Female, Humans, Middle Aged, Neoplasm Recurrence, Local, Neoplasm Staging, Proportional Hazards Models, Radiotherapy Dosage, Regression Analysis, Retrospective Studies, Survival Analysis, Treatment Outcome, Antineoplastic Agents, Hormonal therapeutic use, Breast Neoplasms drug therapy, Tamoxifen therapeutic use
- Abstract
Purpose: To evaluate if in low-risk breast cancer patients (pT1a-pT1b, pN0) tamoxifen can reduce local recurrence and improve survival., Methods: Retrospectively 700 patients were analyzed. All patients were treated from 1980 to 2003 with conservative surgery plus radiotherapy at the University of Florence. No patients were treated with adjuvant chemotherapy. Tamoxifen was prescribed in 359 patients (51.3%). The crude probability of survival (or local recurrence) was estimated by using Kaplan-Meier method, and survival (or local recurrence) comparisons were carried out using Cox proportional hazard regression models., Results: The univariate analysis for specific survival showed that only histological type and local recurrence were significant prognostic factors (log rank test: p=0.02 and p<0.0001, respectively). The Cox regression model by stepwise selection confirmed lobular histological type (p=0.008; HR: 3.83, 95% CI: 1.31-11.21) and local recurrence (p<0.001; HR: 9.05, 95% CI: 3.05-26.82) as independent prognostic factors for disease specific survival. For local disease free survival, multivariate analysis did not show any significant parameters., Conclusion: In our series tamoxifen did not seem to improve disease specific survival and local disease specific survival. The number of events in terms of death for cancer or in terms of local recurrence is too small in this group of patients. However, according to our results we suggest not to prescribe tamoxifen in patients affected by pT1a-pT1b, pN0 breast cancer.
- Published
- 2007
- Full Text
- View/download PDF
16. Survival and breast relapse in 3834 patients with T1-T2 breast cancer after conserving surgery and adjuvant treatment.
- Author
-
Livi L, Paiar F, Saieva C, Scoccianti S, Dicosmo D, Borghesi S, Agresti B, Nosi F, Orzalesi L, Santini R, Barca R, and Biti GP
- Subjects
- Adult, Aged, Aged, 80 and over, Breast Neoplasms drug therapy, Breast Neoplasms mortality, Breast Neoplasms radiotherapy, Combined Modality Therapy, Disease-Free Survival, Female, Humans, Kaplan-Meier Estimate, Middle Aged, Proportional Hazards Models, Prospective Studies, Regression Analysis, Tamoxifen therapeutic use, Antineoplastic Agents therapeutic use, Breast Neoplasms surgery, Mastectomy, Segmental, Neoplasm Recurrence, Local prevention & control
- Abstract
Purpose: The aim of the present analysis is to determine the long-term results in terms of breast relapse and specific survival in patients treated with conserving surgery and adjuvant treatment for early breast cancer., Methods: From January 1980 to December 2001, 3834 patients with pT1-T2 breast cancer were treated consecutively at the University of Florence. The median age of the patient population was 55 years (range 30-80). All patients were followed for a median of 7.4 years (range 0.6 year to 22.5 years). The crude probability of survival (or local recurrence) was estimated by using Kaplan-Meier method, and survival (or local recurrence) comparisons were carried out using Cox proportional hazard regression models., Results: The Cox regression model by stepwise selection showed some parameters, such as chemotherapy (HR 1.53; CI 1.19-1.95), pT status (HR 1.62, CI 1.31-2.01), positive axillary lymph nodes (HR 1.92, CI 1.66-2.22), and local recurrence (HR 4.58; CI 3.66-5.73), as independent prognostic factors for breast cancer death. Moreover, we found lower rate survival among patients treated before 1991 in comparison to women treated after 1991 (p=0.0001) probably due to inadequate treatment. For local disease free survival, age at presentation (HR 0.47; CI 0.35-0.63), use of tamoxifen (HR 0.42; CI 0.25-0.71), surgical margins (HR 2.00; CI 1.21-3.30), and chemotherapy (HR 0.53; CI 0.31-0.91) emerged by multivariate analyses as significant breast relapse predictors., Conclusion: In our experience breast conserving surgery followed by adjuvant radiotherapy treatment gives high rates of local control in women with early breast cancer. The use of routinely adjuvant chemotherapy and hormone therapy lowered the local recurrence and probably the modification of therapeutic approach in the last decades also improved the specific survival.
- Published
- 2007
- Full Text
- View/download PDF
17. Adjuvant hypofractionated radiation therapy for breast cancer after conserving surgery.
- Author
-
Livi L, Stefanacci M, Scoccianti S, Dicosmo D, Borghesi S, Nosi F, Simontacchi G, Mangoni M, Paiar F, Ponticelli P, Nori J, Chiavacci A, and Biti GP
- Subjects
- Adult, Aged, Aged, 80 and over, Axilla, Breast Neoplasms pathology, Breast Neoplasms surgery, Carcinoma, Ductal, Breast radiotherapy, Carcinoma, Ductal, Breast secondary, Carcinoma, Ductal, Breast surgery, Carcinoma, Lobular radiotherapy, Carcinoma, Lobular secondary, Carcinoma, Lobular surgery, Chemotherapy, Adjuvant, Combined Modality Therapy, Dose Fractionation, Radiation, Female, Follow-Up Studies, Humans, Lymph Node Excision, Menopause, Middle Aged, Neoplasm Recurrence, Local, Neoplasm Staging, Radiotherapy Dosage, Radiotherapy, Adjuvant, Survival Rate, Breast Neoplasms radiotherapy, Mastectomy, Segmental
- Abstract
Aims: To evaluate the incidence of locoregional recurrence (LRR) and the cosmetic results in a group of patients with breast cancer treated with a hypofractionated schedule of adjuvant radiotherapy after conservative surgery., Materials and Methods: In total, 539 patients with pTis-pT1-pT2 breast cancer underwent radiotherapy treatment after conservative surgery at the University of Florence and at the Pistoia Hospital. The dose delivered was 44 Gy (2.75 Gy daily fraction). The tumour bed boost (10 Gy) was given by electrons., Results: At the time of the analysis, 1.8% of patients (10/539) had breast relapse. No patients developed nodal recurrence (supraclavicular, axillary and internal mammary nodes). The 3- and 5-year actuarial rates for LRR were 1.2% (+/- 0.5% standard error) and 2.1% (+/- 0.6% standard error), respectively. Considering the late toxicity, we found that 412 (76.4%) patients had grade 0 or grade 1 late toxicity, 113 patients (20.9%) had grade 2 late toxicity and 14 patients (2.5%) had grade 3 late toxicity. No patients developed grade 4 toxicity., Conclusion: This type of approach resulted in an effective treatment in terms of local control in patients with negative or one to three positive axillary nodes and negative surgical margins. Patients treated with a hypofractionated schedule showed very good cosmesis.
- Published
- 2007
- Full Text
- View/download PDF
18. Alternating intravenous and oral vinorelbine plus epirubicin with pegfilgrastim as neoadjuvant treatment of locally advanced breast cancer.
- Author
-
Livi L, Paiar F, Santini R, De Luca Cardillo C, Galardi A, Di Cosmo D, Borghesi S, Agresti B, Nosi F, Gavilli S, and Biti GP
- Subjects
- Administration, Oral, Adult, Aged, Epirubicin administration & dosage, Female, Filgrastim, Granulocyte Colony-Stimulating Factor administration & dosage, Humans, Infusions, Intravenous, Middle Aged, Neoadjuvant Therapy, Polyethylene Glycols, Recombinant Proteins, Vinblastine administration & dosage, Vinblastine analogs & derivatives, Vinorelbine, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Breast Neoplasms drug therapy
- Abstract
In order to downstage locally advanced breast cancer, neoadjuvant chemotherapy consisting of intravenous vinorelbine 25 mg/m plus epirubicin 75 mg/m given on day 1 and oral vinorelbine 60 mg/m on day 8 was administered every 3 weeks for four courses. On day 2, all patients received a single subcutaneous injection of pegfilgrastim (6 mg). From March 2004 to June 2005, 22 patients were enrolled. Patients characteristics were: median age, 53 years (range: 39-70 years); postmenopausal, 7/22; clinical TNM stage, T2 (n=14), T3 (n=8), N0 (n=17) and N1 (n=5). The median number of courses was four (range: two to six courses) with full dose intensity. National Cancer Institute grade 3 haematological toxicities observed were neutropenia in 9% of patients, anaemia in 13% of patients and thrombocytopenia in 9% of patients; no toxicity grade 4 occurred. Two patients (9%) registered grade 2 polyneuropathy; no cardiac failure was observed. Conservative surgery was performed in 14 patients (63%). All patients were evaluable for response: complete pathological response was documented in three patients (13.6%); three patients (13.6%) obtained more than 75% of tumour size reduction; 11 other patients (50%) had 50% of tumour size reduction; stable disease was observed in five patients (22.7%). The present findings indicate that vinorelbine in combination with epirubicin is an effective and safe treatment in locally advanced breast cancer: this regimen obtained more than 50% of tumour size reduction in 77% of patients; the use of pegfilgrastim allowed full dose intensity. Oral vinorelbine on day 8 offers greater convenience to the patient by reducing the need for intravenous injection and the time spent in hospital.
- Published
- 2006
- Full Text
- View/download PDF
19. The management of elderly patients with T1-T2 breast cancer treated with or without radiotherapy.
- Author
-
Livi L, Paiar F, Meldolesi E, Bianchi S, Cardona G, Cataliotti L, Crocetti E, Distante V, Simontacchi G, Scoccianti S, Talamonti C, Pallotta S, and Biti GP
- Subjects
- Aged, Breast Neoplasms pathology, Breast Neoplasms radiotherapy, Case-Control Studies, Combined Modality Therapy, Female, Humans, Lymphatic Metastasis, Middle Aged, Neoplasm Recurrence, Local, Prognosis, Proportional Hazards Models, Radiotherapy, Adjuvant, Survival Analysis, Breast Neoplasms surgery
- Abstract
Aim: The aim of the current study is to identify a subgroup of patients with breast cancer who have a low risk of local recurrence after conservative surgery in order to avoid radiotherapy treatment., Methods: A group of 472 patients underwent conservative surgery without radiotherapy, and it was compared to a second group of 755 patients with similar characteristics, but who had received radiotherapy treatment (RT) after conservative surgery., Results: Breast relapse's univariate analysis demonstrated statistical significance for the following factors: radiotherapy treatment, clinical stage, pathological stage, positive axillary nodes and tumour grading. Different results were obtained studying breast relapse. In the no-RT group breast relapse was 10.6% while in the irradiated group it was 3.4%. The breast relapse incidence decreases as the age of the patients increases especially over 75 years of age., Conclusions: In conclusion, there is clinical evidence of avoiding adjuvant radiotherapy for patients over 75 years with T1-T2 cancer treated with quadrantectomy with a clear excision margin.
- Published
- 2005
- Full Text
- View/download PDF
20. Short-course versus split-course radiotherapy in metastatic spinal cord compression: results of a phase III, randomized, multicenter trial.
- Author
-
Maranzano E, Bellavita R, Rossi R, De Angelis V, Frattegiani A, Bagnoli R, Mignogna M, Beneventi S, Lupattelli M, Ponticelli P, Biti GP, and Latini P
- Subjects
- Adult, Aged, Aged, 80 and over, Confidence Intervals, Dose Fractionation, Radiation, Dose-Response Relationship, Radiation, Female, Humans, Male, Middle Aged, Probability, Prognosis, Prospective Studies, Radiation Dosage, Radiation Injuries prevention & control, Radiotherapy, Conformal adverse effects, Risk Assessment, Spinal Cord Compression etiology, Spinal Cord Compression mortality, Spinal Cord Neoplasms complications, Spinal Cord Neoplasms mortality, Survival Analysis, Treatment Outcome, Radiotherapy, Conformal methods, Spinal Cord Compression pathology, Spinal Cord Compression radiotherapy, Spinal Cord Neoplasms radiotherapy, Spinal Cord Neoplasms secondary
- Abstract
Purpose: Hypofractionated radiotherapy (RT) is often used in the treatment of metastatic spinal cord compression (MSCC). This randomized trial was planned to assess the clinical outcome and toxicity of two different hypofractionated RT regimens in MSCC., Patients and Methods: Three hundred patients with MSCC were randomly assigned to a short-course RT (8 Gy x 2 days) or to a split-course RT (5 Gy x 3; 3 Gy x 5). Only patients with a short life expectancy entered the protocol. Median follow-up was 33 months (range, 4 to 61 months)., Results: A total of 276 (92%) patients were assessable; 142 (51%) treated with the short-course and 134 (49%) treated with the split-course RT regimen. There was no significant difference in response, duration of response, survival, or toxicity found between the two arms. When short- versus split-course regimens were compared, after RT 56% and 59% patients had back pain relief, 68% and 71% were able to walk, and 90% and 89% had good bladder function, respectively. Median survival was 4 months and median duration of improvement was 3.5 months for both arms. Toxicity was equally distributed between the two arms: grade 3 esophagitis or pharyngitis was registered in four patients (1.5%), grade 3 diarrhea occurred in four patients (1.5%), and grade 3 vomiting or nausea occurred in 10 patients (6%). Late toxicity was never recorded., Conclusion: Both hypofractionated RT schedules adopted were effective and had acceptable toxicity. However, considering the advantages of the short-course regimen in terms of patient convenience and machine time, it could become the RT regimen of choice in the clinical practice for MSCC patients.
- Published
- 2005
- Full Text
- View/download PDF
21. Tubular carcinoma of the breast: outcome and loco-regional recurrence in 307 patients.
- Author
-
Livi L, Paiar F, Meldolesi E, Talamonti C, Simontacchi G, Detti B, Salerno S, Bianchi S, Cardona G, and Biti GP
- Subjects
- Adult, Aged, Aged, 80 and over, Antineoplastic Agents, Hormonal therapeutic use, Axilla pathology, Chemotherapy, Adjuvant, Combined Modality Therapy, Female, Humans, Lymphatic Metastasis, Mastectomy, Mastectomy, Segmental, Middle Aged, Neoplasm Recurrence, Local, Proportional Hazards Models, Radiotherapy, Adjuvant, Survival Analysis, Tamoxifen therapeutic use, Treatment Outcome, Adenocarcinoma therapy, Breast Neoplasms therapy, Carcinoma, Ductal, Breast therapy
- Abstract
Purpose: The aim of this study is to describe the University of Florence experience in evaluating clinical, pathologic and treatment factors as they are related to the outcome and loco-regional recurrence in patients with tubular breast carcinoma., Material and Methods: Three hundred and seven patients (median age 56.4 years, range 26-91 years) with histological verified tubular carcinoma of the breast were consecutively treated at University of Florence from 1976 to 2001. All patients were followed for a median of 8.4 years (range 3 months to 20 years). Thirty-seven women underwent mastectomy and 270 underwent breast conserving surgery. Positive axillary nodes were found in 15% of patients. Fifty-two patients did not undergo radiotherapy to whole breast after having breast conserving surgery. Tamoxifen was prescribed in 108 patients and chemotherapy in 21 patients, 15 out of 21 had positive axillary nodes., Results: Cause specific survival was 99.6, 99.2 and 97.2% at 3, 5 and 10 years. Local recurrence rate was 1.9, 3.6 and 4.7% at 3, 5 and 10 years. Univariate statistical analysis was significant for specific survival and local recurrence for angiolymphatic invasion only (p=0.0004)., Conclusions: In the absence of axillary disease and angiolymphatic invasion, conserving surgery with adjuvant radiotherapy is effective treatment of disease.
- Published
- 2005
- Full Text
- View/download PDF
22. Uterine sarcoma: twenty-seven years of experience.
- Author
-
Livi L, Paiar F, Shah N, Blake P, Villanucci A, Amunni G, Barca R, Judson I, Lodge N, Meldolesi E, Simontacchi G, Piperno G, Galardi A, Scoccianti S, Biti GP, and Harmer C
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Humans, Middle Aged, Multivariate Analysis, Radiotherapy Dosage, Sarcoma mortality, Sarcoma pathology, Sarcoma radiotherapy, Leiomyosarcoma mortality, Leiomyosarcoma pathology, Leiomyosarcoma radiotherapy, Mixed Tumor, Mullerian mortality, Mixed Tumor, Mullerian pathology, Mixed Tumor, Mullerian radiotherapy, Sarcoma, Endometrial Stromal mortality, Sarcoma, Endometrial Stromal pathology, Sarcoma, Endometrial Stromal radiotherapy, Uterine Neoplasms mortality, Uterine Neoplasms pathology, Uterine Neoplasms radiotherapy
- Abstract
Purpose: A correlation of treatment for uterine sarcoma with outcome, prognostic importance of pathology, and clinical parameters., Patients and Methods: One hundred forty-one patients (median age: 56 years, range: 19-85 years) with a histologically verified uterine sarcoma were identified from a database compiled at the Royal Marsden Hospital and the University of Florence between 1974 and 2001. Seventy-two patients had leiomyosarcoma, 42 had mixed müllerian tumors, 22 had endometrial stromal sarcoma, 1 hemangiopericytoma, 1 rhabdomyosarcoma, and 3 patients had unspecified sarcoma. According to FIGO classification, Stage I, II, III, and IV tumors were identified in 71, 13, 31, and 26 patients, respectively., Results: At the time of analysis, 73.7% of patients were dead, and 26.3% were alive with a median survival of 2 years from initial diagnosis. Univariate analysis for cause-specific survival demonstrated statistical significance for histology (p = 0.02), grade (p = 0.003), stage (p = 0.007), and age (p = 0.02). Multivariate analysis demonstrated significant prognostic values for stage (p = 0.02) and histology (p = 0.05) only. Postoperative radiotherapy with a total dose higher than 50 Gy seems to be significant (p = 0.001) in reducing local recurrence., Conclusions: Our data favor treatment for Stages I, II, and III of uterine sarcoma with radical surgery plus radical dose irradiation comprising both external beam radiotherapy and brachytherapy.
- Published
- 2003
- Full Text
- View/download PDF
23. Comparison of the conventional 'box technique' with two different 'conformal' beam arrangements for prostate cancer treatment.
- Author
-
Magrini SM, Cellai E, Rossi F, Pertici M, Compagnucci A, and Biti GP
- Subjects
- Aged, Femur Head, Humans, Male, Middle Aged, Radiotherapy Dosage, Rectum, Urinary Bladder, Prostatic Neoplasms radiotherapy, Radiotherapy, Conformal
- Abstract
Purpose: To quantify the possible advantages arising from the use of 'conformal' radiotherapy of localized prostate cancer, and to compare the dose distributions obtained with two different 'conformal' techniques., Patients and Methods: Twelve patients with localized prostate cancer were enrolled in the study. For each patient, three techniques were planned: the standard 'box technique' (A), a four-fields 'conformal' technique (B), and a 6-fields conformal technique (C). For each of the 36 3D plans, dose-volume histograms (DVH) were obtained, along with the mean, maximum and minimum doses for the clinical and planning target volumes (CTV, PTV) for the rectum, the bladder, and the femoral heads. The resulting data were compared., Results: On average, the standard technique resulted in the exposure of a significantly larger bladder volume to the higher doses; a similar, but less remarkable difference has been observed for the rectal volume. The coverage of the PTV appears to be significantly more homogeneous with the two conformal techniques., Conclusions: The results presented here add to the evidence available in the literature and suggest a possible advantage of both the conformal techniques over the standard 'box technique' for the treatment of localized prostate cancer. The 6-field conformal technique does not seem superior to the four field one.
- Published
- 1999
- Full Text
- View/download PDF
24. Radical radiotherapy of localised prostate cancer: the relationship between radiation dose and survival.
- Author
-
Magrini SM, Cellai E, Pertici M, Rossi F, Ponticelli P, Odantini R, Cappellini M, and Biti GP
- Subjects
- Adenocarcinoma blood, Analysis of Variance, Humans, Male, Neoplasm Staging, Prostate-Specific Antigen blood, Prostatic Neoplasms blood, Radiotherapy Dosage, Retrospective Studies, Adenocarcinoma mortality, Adenocarcinoma radiotherapy, Prostatic Neoplasms mortality, Prostatic Neoplasms radiotherapy
- Abstract
Purpose: This retrospective study aims to define the effects of different radiation dose levels on survival, local control and toxicity in a series of 208 patients with localised prostate cancer consecutively treated with radical radiation therapy., Patients and Methods: From 1982 through 1996, 365 patients with prostate cancer have been consecutively treated with radical radiotherapy in Florence (n = 306) and Arezzo (n = 59). The 208 cases treated until January 1994 with Stage B (125/208, 60%) and C (83/208, 40%) are the objects of the present study. The treatment was most often limited to the prostatic area (81%), using a four-field "box technique" and 25 MV photon beams, up to a total dose of 60-65 Gy (21% of the patients), of 66-69 Gy (26%) and of 70 Gy (53%); conventional fractionation was used (fractional dose: 2 Gy; five fractions/week). Hormonal therapy was also given to 39% of the cases. The possible relationship between dose, stage, grading and survival has been analysed. The survival figures and the types of relapse observed (prostatic, lymphnodal or "biochemical") have been analysed also according to the extent of the target volume and to the prostate-specific antigen (PSA) value at diagnosis, in the entire series or in selected subgroups., Results: In the whole series and also after radiation alone, the patients with Stage B, with more differentiated tumours and those treated with higher doses to the prostate obtained significantly better survival results. Multivariate analysis confirmed that the dose level has an independent prognostic value. The use of a limited target volume did not produce an excess of pelvic lymphnodal failures. Among the patients more recently treated with radiation alone, the PSA level at diagnosis is strongly related with the risk of local and "biochemical" failure, and also with the relapse-free survival. Toxicity was acceptable, also for the patients treated with higher doses, but late treatment-related damage is more frequent in patients treated on larger volumes., Conclusion: The results of this retrospective analysis confirm the good results of small volume, high dose radiation therapy of prostatic cancer, even taking into account the possible biases due to the retrospective nature of the study, and the relevance of the PSA level at diagnosis to define the risk of local failure.
- Published
- 1998
- Full Text
- View/download PDF
25. Extended-field radiotherapy is superior to MOPP chemotherapy for the treatment of pathologic stage I-IIA Hodgkin's disease: eight-year update of an Italian prospective randomized study.
- Author
-
Biti GP, Cimino G, Cartoni C, Magrini SM, Anselmo AP, Enrici RM, Bellesi GP, Bosi A, Papa G, and Giannarelli D
- Subjects
- Actuarial Analysis, Female, Hodgkin Disease pathology, Humans, Male, Mechlorethamine administration & dosage, Multivariate Analysis, Neoplasm Staging, Prednisone administration & dosage, Procarbazine administration & dosage, Prospective Studies, Radiotherapy methods, Recurrence, Survival Analysis, Vincristine administration & dosage, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Hodgkin Disease drug therapy, Hodgkin Disease radiotherapy
- Abstract
Purpose: To compare the effectiveness of chemotherapy (CHT) with extended-field radiotherapy (RT) in the treatment of early-stage Hodgkin's disease (ESHD), we report an 8-year updated analysis of a study in which treatment with six cycles of mechlorethamine, vincristine, procarbazine, and prednisone (MOPP) CHT was randomly compared with extended-field RT., Patients and Methods: From August 1979 to December 1982, 89 adult patients with pathologic stage I-IIA Hodgkin's disease (HD) were randomly allocated to receive either RT with mantle field followed by periaortic irradiation (n = 45) or six monthly courses of MOPP CHT (n = 44)., Results: All patients in the RT arm and 40 of 44 in the CHT arm achieved complete remission. Twelve relapses occurred in each group. Eight patients treated with MOPP and two of the RT arm died of HD. Three other patients of the CHT group died because of a second cancer. With a median follow-up greater than 8 years, the overall survival rate is significantly higher in the RT than in the CHT group (93% v 56%; P less than .001), whereas the rates of freedom from progression and relapse-free survival (RFS) were similar in the two groups (76% v 64% and 70% v 71%, respectively). Of the 12 patients relapsing after RT, 11 (92%) achieved a second CR, compared with only six of the 12 (50%) in the MOPP group. Analysis of the response rate to salvage treatments showed that the type of relapse in the MOPP group was a prognostic indicator for the achievement of a second CR, whereas in the RT group, a second CR was obtained regardless of the characteristics of the relapses. At 80 months, the probability of survival of relapsing patients calculated from time of relapse was 85% and 15% in the RT and CHT groups, respectively (P = .02)., Conclusion: We conclude that RT alone is the treatment of choice for adult patients with ESHD with favorable prognostic factors.
- Published
- 1992
- Full Text
- View/download PDF
26. Chemotherapy versus radiotherapy in early-stage Hodgkin's disease: evidence of a more difficult rescue for patients relapsed after chemotherapy.
- Author
-
Cimino G, Biti GP, Cartoni C, and Magrini SM
- Subjects
- Antineoplastic Combined Chemotherapy Protocols therapeutic use, Hodgkin Disease pathology, Humans, Mechlorethamine administration & dosage, Prednisone administration & dosage, Procarbazine administration & dosage, Prognosis, Time Factors, Vincristine administration & dosage, Hodgkin Disease drug therapy, Hodgkin Disease radiotherapy, Salvage Therapy
- Abstract
Six cycles of mechloretamine, vincristine, procarbazine and prednisone (MOPP) chemotherapy were randomly compared with extended field radiotherapy (RT) in 89 adult patients with pathological stage I-II A Hodgkin's disease (HD). 45 patients received RT and 44 were treated with MOPP. Complete remission (CR) was obtained in all patients in the RT group and in 40 of 44 in the MOPP group. 12 patients relapsed in both groups. 10 out of 44 patients treated with MOPP died of HD, compared with only 2 in the RT group. 3 more patients died in the MOPP group following the occurrence of second cancers. 11 out of the 12 (96%) patients relapsing after RT achieved a second CR, compared with 6 out of the 12 (50%) patients relapsing after MOPP. Analysis of the response rate with salvage treatment, shows that, of the 12 patients who relapsed after MOPP, the pattern of relapse might predict the likelihood of achieving a second CR, whereas in the RT group a second CR was achieved regardless of the characteristics of relapse. Survival probability for relapsing patients at 80 months calculated from relapse was 85% in the RT group and 15% in the MOPP group (P = 0.02). With a median follow-up of more than 8 years, the overall survival of patients was significantly better for RT compared with MOPP; 93 and 56%, respectively (P < 0.001). On the basis of these results we conclude that, to date, RT alone remains the treatment of choice for adult patients with early-stage HD with favourable prognostic factors.
- Published
- 1992
- Full Text
- View/download PDF
27. Long-term nervous system damage from radiation of the spinal cord: an electrophysiological study.
- Author
-
de Scisciolo G, Bartelli M, Magrini S, Biti GP, Guidi L, and Pinto F
- Subjects
- Adult, Central Nervous System physiopathology, Electric Stimulation, Evoked Potentials, Somatosensory physiology, Female, Hodgkin Disease physiopathology, Hodgkin Disease radiotherapy, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Motor Cortex physiology, Radiation Injuries pathology, Reaction Time, Spinal Cord physiology, Sural Nerve physiology, Tibial Nerve physiology, Time Factors, Central Nervous System radiation effects, Radiation Injuries physiopathology, Spinal Cord radiation effects
- Abstract
A group of 13 patients suffering from Hodgkin's disease who had undergone chemotherapy and radiotherapy (above and below the diaphragm) approximately 10 years earlier was studied. The total chemotherapeutic dose was similar for all patients; the radiotherapy dose, however, was standard for 7 patients, while the other 6 received much higher dosages over limited regions of the spinal cord. Although most of these patients appeared normal both clinically and on magnetic resonance imaging, a neurophysiological study was performed to determine whether there was any involvement of the central or peripheral nervous system. Motor conduction velocity and sensory conduction velocity were measured in the lower limbs as well as spinal- and scalp-recorded somatosensory evoked potentials (SEPs) in response to stimulation of the posterior tibial and sural nerves at the ankle. In addition, motor evoked potentials were recorded from the upper and lower limbs during cortical stimulation. All neurophysiological data were normal in patients who had received a standard radiation dose, while most of those who had been exposed to higher doses showed altered cortical SEPs and a slowing of central conduction time (D10-P1). Thus even though they were asymptomatic, these patients appeared to have sustained CNS damage, mainly at the level of the spinal cord.
- Published
- 1991
- Full Text
- View/download PDF
28. Neurological damage in patients irradiated twice on the spinal cord: a morphologic and electrophysiological study.
- Author
-
Magrini SM, Biti GP, de Scisciolo G, Bartelli M, Pinto F, Caramella D, and Villari N
- Subjects
- Adult, Evoked Potentials, Somatosensory radiation effects, Follow-Up Studies, Hodgkin Disease drug therapy, Hodgkin Disease radiotherapy, Humans, Magnetic Resonance Imaging, Middle Aged, Radiotherapy Dosage, Myelitis etiology, Radiation Injuries etiology, Spinal Cord radiation effects
- Abstract
We reviewed the files of 950 patients treated for Hodgkin's disease since 1966 and were able to find five patients treated with radiochemotherapy and irradiated twice on volumes including a cord segment, at various time intervals, and surviving until now. Seven patients with comparable clinical and therapeutic features, but not reirradiated on the cord, were chosen as a control group and were examined with the same diagnostic procedures. The cumulative cord dose in the reirradiated patients was recalculated and ranged from 50 to 70 Gy. All these patients and the control cases were followed up for more than 10 years and presented no or only minor neurological symptoms. We compare the results of both magnetic resonance imaging (MRI) and electrophysiological studies (spinal and scalp recorded somatosensory evoked potentials--SEPs) in an attempt to define the characteristics of the subclinical damage present in these patients. While no cord abnormality was demonstrated with MRI, electrophysiological studies evidenced a clear difference between cases and controls, as far as the D10-P1 conduction time and SEPs average amplitude are concerned. Advantages and drawbacks of a wider use of electrophysiological methods in research work on cord radiation damage are presented, along with the possible implications of the results obtained for the understanding of the pathogenesis and of the dose dependence of radiation myelitis (RM).
- Published
- 1990
- Full Text
- View/download PDF
29. [Carcinoma of the nasopharynx. Experience of the Institute of Radiology of the University of Florence (author's transl)].
- Author
-
Villari N, Biti GP, Olmi P, and De Dominicis R
- Subjects
- Adolescent, Adult, Aged, Bone Neoplasms, Carcinoma radiotherapy, Carcinoma, Squamous Cell radiotherapy, Child, Cobalt Radioisotopes, Female, Humans, Lymphatic Metastasis, Male, Middle Aged, Nasopharyngeal Neoplasms diagnosis, Neoplasm Metastasis, Prognosis, Radioisotope Teletherapy, Radiotherapy, High-Energy, Nasopharyngeal Neoplasms radiotherapy
- Published
- 1974
30. MOPP chemotherapy versus extended-field radiotherapy in the management of pathological stages I-IIA Hodgkin's disease.
- Author
-
Cimino G, Biti GP, Anselmo AP, Maurizi Enrici R, Bellesi GP, Bosi A, Cionini L, Mungai V, Papa G, and Ponticelli P
- Subjects
- Adolescent, Adult, Combined Modality Therapy, Female, Humans, Male, Mechlorethamine administration & dosage, Mechlorethamine adverse effects, Middle Aged, Prednisone administration & dosage, Prednisone adverse effects, Procarbazine administration & dosage, Procarbazine adverse effects, Random Allocation, Vincristine administration & dosage, Vincristine adverse effects, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Hodgkin Disease drug therapy, Hodgkin Disease radiotherapy
- Abstract
In order to assess whether mechlorethamine, vincristine, procarbazine, and prednisone (MOPP) chemotherapy (CT), which is less expensive and more easily available than radiotherapy (RT), is at least as effective as RT in terms of cure rate and has less iatrogenic damage, 89 consecutive patients with Hodgkin's disease (HD) (pathological stage I-IIA) were randomly allocated to receive mantle plus lumbar bar RT (36-45 Gy) or CT (six courses of MOPP). Forty-five patients were entered in the RT group and 44 in the CT group. The median follow-up was 60 months. Complete remission (CR) was obtained in all patients in the RT group and in 40 of 44 patients in the CT group. Overall survival (OS) and disease-free survival (DFS) were, respectively, 87.2% and 72.7% in the CT group and 93.5% and 74% in the RT group. Survival probability of relapsing patients was 76% for the patients in the RT group and 45% in the CT group. Treatment-related complications were more severe in the CT group as compared with the RT group.
- Published
- 1989
- Full Text
- View/download PDF
31. Respiratory function tests after mantle irradiation in patients with Hodgkin's disease.
- Author
-
Cionini L, Pacini P, De Paola E, Corrado A, De Luca Cardillo C, Mungai V, Biti GP, and Ponticelli P
- Subjects
- Adolescent, Adult, Airway Resistance, Child, Child, Preschool, Cobalt Radioisotopes therapeutic use, Dose-Response Relationship, Radiation, Female, Humans, Infant, Lung Volume Measurements, Lymphatic Diseases radiotherapy, Male, Mediastinal Neoplasms radiotherapy, Middle Aged, Pulmonary Fibrosis etiology, Pulmonary Gas Exchange, Pulmonary Ventilation, Radioisotope Teletherapy adverse effects, Respiratory Function Tests, Hodgkin Disease radiotherapy, Lung Diseases etiology, Radiation Injuries etiology
- Abstract
Pulmonary function tests were performed in 43 patients with Hodgkin's disease before mantle irradiation and at 3, 6, 9, 12 and 15 or more months thereafter. Treatment was given with a telecobalt unit to a total dose of 36 to 42 Gy, the higher dose being reserved for cases with considerable mediastinal involvement. The functional parameters explored included static and dynamic lung volumes, gas exchanges, ventilatory efficiency, and airway resistance. Measured parameters were expressed as a percentage of the pre-treatment value (PTV) in the individual patient. In the whole group, only small variations in the functional indices were observed at 3 to 6 months after mantle irradiation. In patients with normal PTVs a greater variation in static and dynamic volumes was observed at 3 to 6 months after mantle irradiation, with complete recovery thereafter. The gas exchange parameters also showed a similar variation at 3 to 6 months but no recovery was demonstrated in the subsequent examinations. No changes in ventilatory efficiency and airway resistance were observed. In patients with abnormal PTVs, usually presenting large mediastinal adenopathy, all parameters improved after mantle irradiation, and the favourable effect of tumour regression was probably more important than the radiation damage on the pulmonary parenchyma.
- Published
- 1984
- Full Text
- View/download PDF
32. Prognostic significance of histologic subdivision of Hodgkin's disease nodular sclerosis.
- Author
-
Cionini L, Arganini L, Mungai V, Biti GP, and Bondi R
- Subjects
- Blood Cell Count, Female, Follow-Up Studies, Hodgkin Disease radiotherapy, Humans, Male, Neoplasm Staging, Prognosis, Sclerosis, Hodgkin Disease pathology
- Abstract
Sixty-seven patients with nodular sclerosis (Hodgkin's disease stages I and II) have been subclassified according to the cellular composition and the amount of fibrosis. Predominance of mature lymphocytes and rarity of Reed Sternberg cells were associated with less extensive disease at presentation and more favourable outcome. A less definite correlation to the amount of fibrosis was found.
- Published
- 1978
- Full Text
- View/download PDF
33. Different fractionation schedules in radiation treatment of cerebral metastases.
- Author
-
D'Elia F, Bonucci I, Biti GP, and Pirtoli L
- Subjects
- Adult, Aged, Brain Neoplasms secondary, Female, Humans, Male, Middle Aged, Radiotherapy Dosage, Brain Neoplasms radiotherapy, Cobalt Radioisotopes therapeutic use, Radioisotope Teletherapy methods
- Abstract
Multiple daily fractionation (MDF) was compared, in a cooperative study, with conventional fractionation (CF) in the radiation treatment of brain metastases. The 103 patients treated by MDF and the 44 given CF showed a similar response, in terms of neurologic improvement, survival, quality of residual life, and treatment-related morbidity. The hypothesis that MDF might give a better therapeutic ratio than CF was not confirmed in the present series. The short time period required gives MDF advantages in clinical practice.
- Published
- 1986
- Full Text
- View/download PDF
34. Brain damage after treatment for acute lymphoblastic leukemia. A report on 34 patients with special regard to MRI findings.
- Author
-
Biti GP, Magrini SM, Villari N, Caramella D, Guazzelli G, Rosi A, and Lippi A
- Subjects
- Brain Damage, Chronic chemically induced, Brain Damage, Chronic etiology, Child, Child, Preschool, Combined Modality Therapy, Female, Humans, Leukoencephalopathy, Progressive Multifocal pathology, Magnetic Resonance Imaging, Male, Radiation Injuries pathology, Brain Damage, Chronic pathology, Precursor Cell Lymphoblastic Leukemia-Lymphoma therapy
- Abstract
In 34 patients treated for acute lymphoblastic leukemia (ALL), central nervous system (CNS) damage was assessed by clinical evaluation and brain magnetic resonance imaging (MRI). Twenty-seven of them had been off therapy from 5 to 109 months (median 64 months) while 7 had not completed the maintenance phase of their treatment. All the patients were disease-free when evaluated. None of the 3 patients who showed clinical CNS damage during the follow-up was symptomatic when submitted to MRI, while periventricular hyperintensity in T2-weighted images, suggestive of leukoencephalopathy, was present in 8 of the 34 patients. These subclinical abnormalities appear to be more frequent, transient in nature and treatment-related in patients evaluated shortly after the induction phase. Similar MRI findings seem, on the contrary, to be consequences of the disease on the CNS when appearing in long-term survivors.
- Published
- 1989
- Full Text
- View/download PDF
35. Stage I and II Hodgkin's disease presenting in infradiaphragmatic nodes.
- Author
-
Cionini L, Magrini S, Mungai V, Biti GP, and Ponticelli P
- Subjects
- Adolescent, Adult, Aged, Female, Hodgkin Disease drug therapy, Hodgkin Disease radiotherapy, Humans, Italy, Male, Middle Aged, Neoplasm Staging, Hodgkin Disease pathology, Lymph Nodes pathology
- Abstract
Twenty patients with Hodgkin's disease limited to infradiaphragmatic (ID) nodes have been treated at the University and Hospital Radiotherapy Departments in Florence between 1960 and 1978. Clinicopathologic features and treatment modalities of these patients were reviewed and results compared with those of 2 similar series previously published by other authors. With respect to the patients with disease above the diaphragm, the ID presentation occurred more often in males in all the 3 reviewed series; a relative prevalence of the lymphocytic predominance histotype and of an older age was observed in 2 only of the 3 series; laparatomy seems unnecessary in lymphographic-negative patients. The analysis of therapeutic results suggests that inverted Y irradiation is a sufficient treatment when inguinal or lower iliac nodes only are affected; paraortic region and spleen involvement warrant a more radical program including the supradiaphragmatic irradiation or systemic chemotherapy.
- Published
- 1982
- Full Text
- View/download PDF
36. Mediastinal involvement in Hodgkin's disease: prognostic factors and distribution of intrathoracic adenopathies.
- Author
-
Cionini L, Villari N, Ponticelli P, Biti GP, and Mungai V
- Subjects
- Adolescent, Adult, Age Factors, Child, Child, Preschool, Female, Humans, Infant, Male, Middle Aged, Neoplasm Staging, Prognosis, Sex Factors, Hodgkin Disease pathology, Mediastinal Neoplasms pathology
- Abstract
The files and the roentgenographic documentation of 624 patients affected by Hodgkin's disease have been reviewed. The presence and location of involved nodes in the different lymph node chains of the mediastinum have been determined and correlated with the distribution of the main anatomoclinic prognostic parameters of the disease. Feminine sex, histology of nodular sclerosis, presence of constitutional symptoms and age younger than 36 were found to be significantly more frequent in patients with mediastinal adenopathies than in patients with a normal mediastinum. Patients with mediastinal adenopathy at presentation were also more likely develop pulmonary involvement as first evidence of new manifestation of disease after the primary treatment. A different probability to be affected by disease was evident among the different lymph node groups in the mediastinum. The involvement of hilar nodes appeared to accompany a more advanced stage of disease and to favour the adjacent lung extension.
- Published
- 1982
37. Waldeyer's ring (WR) involvement in Hodgkin's disease.
- Author
-
Cionini L, Bastiani P, Biti GP, Mungai V, Ponticelli P, and Di Lollo S
- Subjects
- Adolescent, Adult, Age Factors, Child, Female, Hodgkin Disease pathology, Hodgkin Disease radiotherapy, Humans, Lymph Nodes pathology, Lymphatic Metastasis, Male, Middle Aged, Neck, Tonsillar Neoplasms radiotherapy, Hodgkin Disease diagnosis, Tonsillar Neoplasms diagnosis
- Abstract
Of 750 patients with stage I, II or III Hodgkin's disease, admitted to the University and Hospital Radiotherapy Divisions, Florence, between 1960 and 1981, 28 (3.7%) had involvement of Waldeyer's ring (WR). In 25 patients there was associated involvement of upper cervical nodes. Other factors associated with WR involvement were age over 55 years, lymphocyte predominant histological sub-type, uninvolved mediastinum, and size of involved upper cervical nodes greater than that of involved lower cervical nodes. These factors help to define indications for prophylactic irradiation of WR.
- Published
- 1985
- Full Text
- View/download PDF
38. [Pneumopelvigraphy in the differential diagnosis of hirsutism].
- Author
-
Borghi A, Cavina C, and Biti GP
- Subjects
- Adrenocortical Hyperfunction diagnostic imaging, Diagnosis, Differential, Female, Humans, Methods, Radiography, Hirsutism diagnostic imaging, Pelvis diagnostic imaging
- Published
- 1971
39. Circadian periodicity of calf blood flow in subjects with intermittent claudication.
- Author
-
Bartoli V, Dorigo B, Tedeschi E, Biti GP, and Voegelin MR
- Subjects
- Adult, Aged, Arteriosclerosis Obliterans complications, Blood Flow Velocity, Humans, Hyperemia, Male, Mathematics, Middle Aged, Plethysmography, Circadian Rhythm, Intermittent Claudication physiopathology, Leg blood supply, Regional Blood Flow
- Published
- 1970
- Full Text
- View/download PDF
40. [Vasomotor action of acetylcholine o peripheral occlusive arterial diseases (plethysmograpic findings on the leg during acetylcholine arteriosclerosis)].
- Author
-
Dorigo B and Biti GP
- Subjects
- Humans, Injections, Intra-Arterial, Vasomotor System drug effects, Acetylcholine administration & dosage, Arteriosclerosis Obliterans drug therapy, Blood Flow Velocity, Leg blood supply
- Published
- 1969
41. [Behavior of blood flow in the leg of apparently healthy subjects during a 24-hour period].
- Author
-
Bartoli V, Tedeschi E, Dorigo B, Biti GP, and Voegelin MR
- Subjects
- Adult, Humans, Hyperemia, Male, Middle Aged, Blood Circulation, Blood Flow Velocity, Circadian Rhythm, Leg blood supply
- Published
- 1970
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.