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1. Bestform-F – Best Function of Range of Motion: A Feasibility Study of a Multimodal Exercise Training Program for Older Adults in Retirement Homes

Author

Schaller N, Krusemark H, Mende E, Weiß M, Spanier B, Zelger O, Bischof J, Haller B, Halle M, and Siegrist M

Subjects
machine-based exercise, seniors, sarcopenia, mobility, resistance training, balance, Geriatrics, RC952-954.6
Abstract

Nina Schaller,1 Helge Krusemark,1 Esther Mende,1 Michael Weiß,1 Bianca Spanier,1 Otto Zelger,1 Jan Bischof,1 Bernhard Haller,2 Martin Halle,1,3,&ast; Monika Siegrist1,&ast; 1Department of Prevention and Sports Medicine, School of Medicine, University Hospital ‘rechts der Isar’, Technical University of Munich, Munich, Germany; 2Institute of AI and Informatics in Medicine, University Hospital ‘rechts der Isar’, Technical University of Munich, Munich, Germany; 3DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany&ast;These authors contributed equally to this workCorrespondence: Nina Schaller, Department of Prevention and Sports Medicine, School of Medicine, University Hospital ‘rechts der Isar’, Technical University of Munich, Georg-Brauchle-Ring 56, Munich, 80992, Germany, Tel +49 89 289 24441, Fax +49 89 289 24451, Email nina.schaller@mri.tum.dePurpose: Mobility is a crucial factor for independence and quality of life in old age. Nevertheless, many old people in retirement homes do not meet the physical activity recommendations. The aim of the Bestform-F – Best Function of Range of Motion feasibility study (bestform-F) was to evaluate the feasibility of implementing a machine-based multimodal exercise training program in older residents in retirement homes.Materials and Methods: The participants (n = 77) were recruited from two retirement homes and took part in a six-month multimodal exercise training program (2x/week, 45 minutes) on pneumatic strength training machines, a balance platform and bicycle ergometers. Feasibility criteria were recruitment number ≥ 35 participants within six months, dropout rate < 40% of participants within six months of exercise, and training adherence ≥ 50% of participants taking part in at least 50% of offered training sessions. Additionally, physical performance, fear of falling, cognitive function, and quality of life were assessed at baseline and after six months.Results: For the bestform-F study, 77 (85.6 ± 6.6 years; 78% women) out of 215 eligible residents from two senior residences were recruited. The dropout rate over six months was 10% (8/77 participants). The training adherence rate for the finishing participants was 77% (53/69 participants). In addition to the achieved feasibility criteria, significant improvements were recorded in the Chair Stand Test, Six-Minute Walk Test, and fear of falling after six months.Conclusion: All feasibility criteria have been fulfilled. The high number of recruited participants, the low dropout rate, and high adherence to the training program confirm the feasibility of a multimodal machine-based exercise training program offered to residents in retirement homes. The results provide a basis for a cluster-randomized controlled trial aimed at further investigating the efficacy of the bestform-F program.Keywords: machine-based exercise, seniors, sarcopenia, mobility, resistance training, balance

Published
2022

2. Towards community standards in Adaptive Feedback Microscopy

Author

Balazs, B., Bischof, J., Camacho, R., Gunkel, M., Halavatyi, A., Norlin, N., Pfander, C., Schaden, H., Sisamakis, E., Tewinkel, M., and Thomas, L.

Subjects
microscope controle, adaptive feedback microscopy, smart microscopy, feedback microscopy
Abstract

While there are several software solutions for microscopy control that can be used to implement smart-microscopy workflows, there is no reference specification on what functionalities are needed, or how these workflows could be implemented. To facilitate the development of smart-microscopy applications, and enable their execution across imaging-systems with similar modalities, we, the Smart Microscopy Working Group, are working to establish such a standard specification and to put forth desired workflows, then in dialog we find functionality requirements, reach common terminologies, and share these with the community for feedback and improvement. The working group is composed of participants from both academia and industry, meeting regularly online with the support of the Euro-BioImaging Industry Board., The poster was presented at ELMI 2023 in Noordwijk, Netherlands.

Published
2023
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5. Assessment of stored red blood cells through lab-on-a-chip technologies for precision transfusion medicine

Author

Isiksacan, Z. (Ziya), D’Alessandro, A. (Angelo), Wolf, S. M. (Susan M.), McKenna, D. H. (David H.), Tessier, S. N. (Shannon N.), Kucukal, E. (Erdem), Gokaltun, A. A. (A. Aslihan), William, N. (Nishaka), Sandlin, R. D. (Rebecca D.), Bischof, J. (John), Mohandas, N. (Narla), Busch, M. P. (Michael P.), Elbuken, C. (Caglar), Gurkan, U. A. (Umut A.), Toner, M. (Mehmet), Acker, J. P. (Jason P.), Yarmush, M. L. (Martin L.), Usta, O. B. (O. Berk), Isiksacan, Z. (Ziya), D’Alessandro, A. (Angelo), Wolf, S. M. (Susan M.), McKenna, D. H. (David H.), Tessier, S. N. (Shannon N.), Kucukal, E. (Erdem), Gokaltun, A. A. (A. Aslihan), William, N. (Nishaka), Sandlin, R. D. (Rebecca D.), Bischof, J. (John), Mohandas, N. (Narla), Busch, M. P. (Michael P.), Elbuken, C. (Caglar), Gurkan, U. A. (Umut A.), Toner, M. (Mehmet), Acker, J. P. (Jason P.), Yarmush, M. L. (Martin L.), and Usta, O. B. (O. Berk)

Abstract

Transfusion of red blood cells (RBCs) is one of the most valuable and widespread treatments in modern medicine. Lifesaving RBC transfusions are facilitated by the cold storage of RBC units in blood banks worldwide. Currently, RBC storage and subsequent transfusion practices are performed using simplistic workflows. More specifically, most blood banks follow the “first-in-first-out” principle to avoid wastage, whereas most healthcare providers prefer the “last-in-first-out” approach simply favoring chronologically younger RBCs. Neither approach addresses recent advances through -omics showing that stored RBC quality is highly variable depending on donor-, time-, and processing-specific factors. Thus, it is time to rethink our workflows in transfusion medicine taking advantage of novel technologies to perform RBC quality assessment. We imagine a future where lab-on-a-chip technologies utilize novel predictive markers of RBC quality identified by -omics and machine learning to usher in a new era of safer and precise transfusion medicine.

Published
2023

12. Heat transfer—A review of 2005 literature

Author

Goldstein, R.J., Ibele, W.E., Patankar, S.V., Simon, T.W., Kuehn, T.H., Strykowski, P.J., Tamma, K.K., Heberlein, J.V.R., Davidson, J.H., Bischof, J., Kulacki, F.A., Kortshagen, U., Garrick, S., Srinivasan, V., Ghosh, K., and Mittal, R.

Published
2010
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16. QUAREP-LiMi: A community-driven initiative to establish guidelines for quality assessment and reproducibility for instruments and images in light microscopy

Author

Nelson, G., Boehm, Ulrike, Bagley, S., Bajcsy, P., Bischof, J., Brown, Claire M., Dauphin, A., Dobbie, I.M., Eriksson, J.E., Faklaris, O., Fernandez-Rodriguez, J., Ferrand, A., Gelman, L., Gheisari, A., Hartmann, H., Kukat, C., Laude, A., Mitkovski, M., Munck, S., North, A.J., Rasse, T.M., Resch-Genger, U., Schuetz, L.C., Seitz, A., Strambio-De-Castillia, C., Swedlow, J.R., Alexopoulos, I., Aumayr, K., Avilov, S., Bakker, G.J., Bammann, R.R., Bassi, A., Beckert, H., Beer, S., Belyaev, Y., Bierwagen, J., Birngruber, K.A., Bosch, M., Breitlow, J., Cameron, L.A., Chalfoun, J., Chambers, J.J., Chen, C.L., Conde-Sousa, E., Corbett, A.D., Cordelieres, F.P., Nery, E.D., Dietzel, R., Eismann, F., Fazeli, E., Felscher, A., Fried, H., Gaudreault, N., Goh, W.I., Guilbert, T., Hadleigh, R., Hemmerich, P., Holst, G.A., Itano, M.S., Jaffe, C.B., Jambor, H.K., Jarvis, S.C., Keppler, A., Kirchenbuechler, D., Kirchner, M., Kobayashi, N., Krens, G., Kunis, S., Lacoste, J., Marcello, M., Martins, G.G., Metcalf, D.J., Mitchell, C.A., Moore, J., Mueller, T., Nelson, M.S., Ogg, S., Onami, S., Palmer, A.L., Paul-Gilloteaux, P., Pimentel, J.A., Plantard, L., Podder, S., Rexhepaj, E., Royon, A., Saari, M.A., Schapman, D., Schoonderwoert, V., Schroth-Diez, B., Schwartz, S., Shaw, M., Spitaler, M., Stoeckl, M.T., Sudar, D., Teillon, J., Terjung, S., Thuenauer, R., Wilms, C.D., Wright, G.D., Nitschke, R., Nelson, G., Boehm, Ulrike, Bagley, S., Bajcsy, P., Bischof, J., Brown, Claire M., Dauphin, A., Dobbie, I.M., Eriksson, J.E., Faklaris, O., Fernandez-Rodriguez, J., Ferrand, A., Gelman, L., Gheisari, A., Hartmann, H., Kukat, C., Laude, A., Mitkovski, M., Munck, S., North, A.J., Rasse, T.M., Resch-Genger, U., Schuetz, L.C., Seitz, A., Strambio-De-Castillia, C., Swedlow, J.R., Alexopoulos, I., Aumayr, K., Avilov, S., Bakker, G.J., Bammann, R.R., Bassi, A., Beckert, H., Beer, S., Belyaev, Y., Bierwagen, J., Birngruber, K.A., Bosch, M., Breitlow, J., Cameron, L.A., Chalfoun, J., Chambers, J.J., Chen, C.L., Conde-Sousa, E., Corbett, A.D., Cordelieres, F.P., Nery, E.D., Dietzel, R., Eismann, F., Fazeli, E., Felscher, A., Fried, H., Gaudreault, N., Goh, W.I., Guilbert, T., Hadleigh, R., Hemmerich, P., Holst, G.A., Itano, M.S., Jaffe, C.B., Jambor, H.K., Jarvis, S.C., Keppler, A., Kirchenbuechler, D., Kirchner, M., Kobayashi, N., Krens, G., Kunis, S., Lacoste, J., Marcello, M., Martins, G.G., Metcalf, D.J., Mitchell, C.A., Moore, J., Mueller, T., Nelson, M.S., Ogg, S., Onami, S., Palmer, A.L., Paul-Gilloteaux, P., Pimentel, J.A., Plantard, L., Podder, S., Rexhepaj, E., Royon, A., Saari, M.A., Schapman, D., Schoonderwoert, V., Schroth-Diez, B., Schwartz, S., Shaw, M., Spitaler, M., Stoeckl, M.T., Sudar, D., Teillon, J., Terjung, S., Thuenauer, R., Wilms, C.D., Wright, G.D., and Nitschke, R.

Abstract

Item does not contain fulltext, A modern day light microscope has evolved from a tool devoted to making primarily empirical observations to what is now a sophisticated , quantitative device that is an integral part of both physical and life science research. Nowadays, microscopes are found in nearly every experimental laboratory. However, despite their prevalent use in capturing and quantifying scientific phenomena, neither a thorough understanding of the principles underlying quantitative imaging techniques nor appropriate knowledge of how to calibrate, operate and maintain microscopes can be taken for granted. This is clearly demonstrated by the well-documented and widespread difficulties that are routinely encountered in evaluating acquired data and reproducing scientific experiments. Indeed, studies have shown that more than 70% of researchers have tried and failed to repeat another scientist's experiments, while more than half have even failed to reproduce their own experiments. One factor behind the reproducibility crisis of experiments published in scientific journals is the frequent underreporting of imaging methods caused by a lack of awareness and/or a lack of knowledge of the applied technique. Whereas quality control procedures for some methods used in biomedical research, such as genomics (e.g. DNA sequencing, RNA-seq) or cytometry, have been introduced (e.g. ENCODE), this issue has not been tackled for optical microscopy instrumentation and images. Although many calibration standards and protocols have been published, there is a lack of awareness and agreement on common standards and guidelines for quality assessment and reproducibility. In April 2020, the QUality Assessment and REProducibility for instruments and images in Light Microscopy (QUAREP-LiMi) initiative was formed. This initiative comprises imaging scientists from academia and industry who share a common interest in achieving a better understanding of the performance and limitations of microscopes and improved quality con

Published
2021

24. Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D)

Author

Xu, P., Ianes, C., Gärtner, F., Liu, C., Burster, T., Bakulev, V., Rachidi, N., Knippschild, U., and Bischof, J.

Subjects
GENETIC VARIATION, ENZYME STRUCTURE, GENETIC VARIABILITY, STRESS, ISOENZYME, NEOPLASM, CYTOSKELETON, ANTAGONISTS AND INHIBITORS, DISEASE COURSE, HIPPO SIGNALING, CHEMISTRY, GENE SEQUENCE, PHOSPHORYLATION, PRIORITY JOURNAL, GENETIC TRANSCRIPTION, WNT SIGNALING, SEQUENCE ALIGNMENT, CARCINOGENESIS, SIGNAL TRANSDUCTION, HUMAN, HUMANS, MEIOSIS, CANCER, AMINO ACID SEQUENCE, PROTEIN INTERACTION, METABOLIC DISORDER, GENETIC CODE, ENZYME SUBSTRATE, MITOSIS, CASEIN KINASE IDELTA, HEDGEHOG SIGNALING, TUMOR GROWTH, NEOPLASM PROTEINS, NEOPLASMS, SITE-SPECIFIC PHOSPHORYLATION, GENETICS, SMALL MOLECULE INHIBITOR, CIRCADIAN RHYTHM, PATHOPHYSIOLOGY, ISOENZYMES, MOLECULAR RECOGNITION, CSNK1D, METABOLISM, DNA DAMAGE, DRUG DELIVERY SYSTEMS, POLYADENYLATION, CASEIN KINASE 1, NONHUMAN, REVIEW, CELL CYCLE, CSNK1D GENE, STRUCTURE-ACTIVITY RELATIONSHIP, WNT SIGNALING PATHWAY, P53, PROTEIN TARGETING, ANIMALS, ANIMAL, ENZYME REGULATION, PATHOLOGY, RNA FOLDING, HEDGEHOG PATHWAY, TUMOR PROTEIN, PROCEDURES, DRUG DEPENDENCE, DRUG DELIVERY SYSTEM, STRUCTURE ACTIVITY RELATION, STRESS-INDUCED KINASE, CELL STRESS, CELLULAR DISTRIBUTION, ENZYMOLOGY
Abstract

Members of the highly conserved pleiotropic CK1 family of serine/threonine-specific kinases are tightly regulated in the cell and play crucial regulatory roles in multiple cellular processes from protozoa to human. Since their dysregulation as well as mutations within their coding regions contribute to the development of various different pathologies, including cancer and neurodegenerative diseases, they have become interesting new drug targets within the last decade. However, to develop optimized CK1 isoform-specific therapeutics in personalized therapy concepts, a detailed knowledge of the regulation and functions of the different CK1 isoforms, their various splice variants and orthologs is mandatory. In this review we will focus on the stress-induced CK1 isoform delta (CK1δ), thereby addressing its regulation, physiological functions, the consequences of its deregulation for the development and progression of diseases, and its potential as therapeutic drug target. © 2019 Elsevier B.V.

Published
2019

28. Immune Cells and Immunosenescence

Author

Bischof, J., primary, Gärtner, F., additional, Zeiser, K., additional, Kunz, R., additional, Schreiner, C., additional, Hoffer, E., additional, Burster, T., additional, Knippschild, U., additional, and Zimecki, Michał, additional

Published
2019
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29. Successful cryopreservation of coral larvae using vitrification and laser warming.

Author

Daly, J, Zuchowicz, N, Nuñez Lendo, CI, Khosla, K, Lager, C, Henley, EM, Bischof, J, Kleinhans, FW, Lin, C, Peters, EC, Hagedorn, M, Daly, J, Zuchowicz, N, Nuñez Lendo, CI, Khosla, K, Lager, C, Henley, EM, Bischof, J, Kleinhans, FW, Lin, C, Peters, EC, and Hagedorn, M

Abstract

Climate change has increased the incidence of coral bleaching events, resulting in the loss of ecosystem function and biodiversity on reefs around the world. As reef degradation accelerates, the need for innovative restoration tools has become acute. Despite past successes with ultra-low temperature storage of coral sperm to conserve genetic diversity, cryopreservation of larvae has remained elusive due to their large volume, membrane complexity, and sensitivity to chilling injury. Here we show for the first time that coral larvae can survive cryopreservation and resume swimming after warming. Vitrification in a 3.5 M cryoprotectant solution (10% v/v propylene glycol, 5% v/v dimethyl sulfoxide, and 1 M trehalose in phosphate buffered saline) followed by warming at a rate of approximately 4,500,000 °C/min with an infrared laser resulted in up to 43% survival of Fungia scutaria larvae on day 2 post-fertilization. Surviving larvae swam and continued to develop for at least 12 hours after laser-warming. This technology will enable biobanking of coral larvae to secure biodiversity, and, if managed in a high-throughput manner where millions of larvae in a species are frozen at one time, could become an invaluable research and conservation tool to help restore and diversify wild reef habitats.

Published
2018

30. Heat transfer: a review of 1998 literature

Author

Goldstein, R.J, Eckert, E.R.G, Ibele, W.E, Patankar, S.V, Simon, T.W, Kuehn, T.H, Strykowski, P.J, Tamma, K.K, Bar-Cohen, A, Heberlein, J.V.R, Davidson, J.H, Bischof, J, Kulacki, F.A, Kortshagen, U, and Garrick, S

Published
2001
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32. Heat transfer — a review of 1997 literature

Author

Eckert, E.R.G., Goldstein, R.J., Ibele, W.E., Patankar, S.V., Simon, T.W., Kuehn, T.H., Strykowski, P.J., Tamma, K.K., Bar-Cohen, A., Heberlein, J.V.R., Davidson, J.H., Bischof, J., Kulacki, F.A., Kortshagen, U., and Garrick, S.

Published
2000
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35. Generation of a versatile BiFC ORFeome library for analyzing protein-protein interactions in liveDrosophila

Author

Bischof, J., primary, Duffraisse, M., additional, Furger, E., additional, Ajuria, L., additional, Giraud, G., additional, Vanderperre, S., additional, Paul, R., additional, Björklund, M., additional, Ahr, D., additional, Ahmed, A.W., additional, Spinelli, L., additional, Brun, C., additional, Basler, K., additional, and Merabet, S., additional

Published
2018
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38. New potential peptide therapeutics perturbing CK1δ/α-tubulin interaction

Author

Krüger, M. Kalbacher, H. Kastritis, P.L. Bischof, J. Barth, H. Henne-Bruns, D. Vorgias, C. Sarno, S. Pinna, L.A. Knippschild, U.

Abstract

Members of the CK1 family are highly conserved serine/threonine specific kinases being expressed in all eukaryotes. They are involved in many cellular processes and therefore tightly regulated. A central mechanism to modulate CK1 activity is via interaction with cellular proteins. CK1δ interacts with α-/β-tubulin and is involved in the regulation of microtubule dynamics. Therefore, it is important to identify the structural elements responsible for the interaction between these proteins. Using a peptide library covering the human CK1δ amino acid sequence in SPR and ELISA analyses, we identified peptide 39 (P39), encompassing aa361-aa375 of CK1δ, as a prominent binding partner of α-tubulin. P39 decreases α-tubulin phosphorylation by CK1δ and reduces the thermodynamic stability of α-tubulin in fluorescence thermal shift assays. Furthermore, P39 induces an inhibition of mitotic progression and a disruption of cells entering mitosis in CV-1 cells. Taken together our data provide valuable information regarding the interaction of CK1δ and α-tubulin and a novel approach for the development of pharmacological tools to inhibit proliferation of cancer cells. © 2016 Elsevier Ireland Ltd.

Published
2016

43. Nanowarming of tissues

Author

Manuchehrabadi, N., primary, Gao, Z., additional, Zhang, J., additional, Ring, H., additional, Shao, Q., additional, Liu, F., additional, Chen, Y., additional, Mcdermott, M., additional, Fok, A., additional, Brockbank, K., additional, Garwood, M., additional, Haynes, C., additional, and Bischof, J., additional

Published
2016
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44. The CK1 family: Contribution to cellular stress response and its role in carcinogenesis

Author

Knippschild, U., Krüger, M., Richter, J., Xu, P., Balbina, García-Reyes, Peifer, C., Halekotte, J., Bakulev, V., and Bischof, J.

Subjects
CASEIN KINASE IBETA, INFLAMMATORY PAIN, PROTEIN EXPRESSION, MICROTUBULE ASSOCIATED PROTEIN, TUBULIN, PROTEIN SERINE THREONINE KINASE, CELL DIFFERENTIATION, CASEIN KINASE IEPSILON, UNCLASSIFIED DRUG, CELL CYCLE REGULATION, DISEASE, NUCLEOTIDE SEQUENCE, BETA CATENIN, ENZYME SPECIFICITY, SCAFFOLD PROTEIN, OXIDATIVE STRESS, ACTIVITY REGULATED CYTOSKELETON ASSOCIATED PROTEIN, SIGNAL TRANSDUCTION, SONIC HEDGEHOG PROTEIN, CARCINOGENESIS, INHIBITOR, HUMAN, M PHASE CELL CYCLE CHECKPOINT, APOPTOSIS, OVARY CANCER, VIRUS PROTEIN, CELLULAR STRESS, HIPPO SIGNALING PATHWAY, CELL PROTEIN, CASEIN KINASE IDELTA, ALCOHOLISM, TUMOR GROWTH, CASEIN KINASE IALPHA, GENE EXPRESSION, PHOSPHATASE, PROTEIN KINASE, FIBRONECTIN, CELLULAR STRESS RESPONSE, PROTEIN MDM2, BREAST CARCINOMA, CELL DIVISION, DNA DAMAGE, INFLAMMATION, CASEIN KINASE 1, IMMUNE RESPONSE, GENE MUTATION, TUMORIGENESIS, CENTROSOME, REVIEW, CASEIN KINASE IGAMMA 1, TUMOR ANTIGEN, CASEIN KINASE IGAMMA 2, CASEIN KINASE IGAMMA 3, GENETIC ANALYSIS, WNT SIGNALING PATHWAY, CIRCADIAN RHYTHM SIGNALING PROTEIN, P53, MOUTH ULCER, PROTEIN P53, ADENOCARCINOMA, PROTEIN STRUCTURE, CASEIN KINASE I
Abstract

Members of the highly conserved and ubiquitously expressed pleiotropic CK1 family play major regulatory roles in many cellular processes including DNA-processing and repair, proliferation, cytoskeleton dynamics, vesicular trafficking, apoptosis, and cell differentiation. As a consequence of cellular stress conditions, interaction of CK1 with the mitotic spindle is manifold increased pointing to regulatory functions at the mitotic checkpoint. Furthermore, CK1 is able to alter the activity of key proteins in signal transduction and signal integration molecules. In line with this notion, CK1 is tightly connected to the regulation and degradation of ß-catenin, p53, and MDM2. Considering the importance of CK1 for accurate cell division and regulation of tumor suppressor functions, it is not surprising that mutations and alterations in the expression and/or activity of CK1 isoforms are often detected in various tumor entities including cancer of the kidney, choriocarcinomas, breast carcinomas, oral cancer, adenocarcinomas of the pancreas, and ovarian cancer. Therefore, scientific effort has enormously increased (i) to understand the regulation of CK1 and its involvement in tumorigenesis- and tumor progression-related signal transduction pathways and (ii) to develop CK1-specific inhibitors for the use in personalized therapy concepts. In this review, we summarize the current knowledge regarding CK1 regulation, function, and interaction with cellular proteins playing central roles in cellular stress-responses and carcinogenesis. © 2014 Knippschild.

Published
2014

50. A New Approach for CO-based Control of Small-scale Biomass Furnaces

Author

Bischof, J., Baumbach, G., and Struschka, M.

Subjects
Biomass
Abstract

In this summary, the author presents a new approach for the control and optimization of small-scale biomass furnaces, based onlyon the carbon monoxide content of the exhaust gases. The main components of the control algorithm are described toenable the reader to understand the main structure and core ideas of the control loop. This paper illustrates and discusses the resultsof experiments on a market-available small-scale furnace for wood pellets and it demonstrates that carbon monoxide basedcontrolsystems can deliver significant benefits and offer a promising alternative to conventional control strategies., Proceedings of the 21st European Biomass Conference and Exhibition, 3-7 June 2013, Copenhagen, Denmark, pp. 1125-1128

Published
2013
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