37 results on '"Biscans, Annabelle"'
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2. Single intravitreal administration of a tetravalent siRNA exhibits robust and efficient gene silencing in mouse and pig photoreceptors
3. Engineered ionizable lipid siRNA conjugates enhance endosomal escape but induce toxicity in vivo
4. RNAi-based modulation of IFN-γ signaling in skin
5. Hydrophobically Modified let-7b miRNA Enhances Biodistribution to NSCLC and Downregulates HMGA2 In Vivo
6. The valency of fatty acid conjugates impacts siRNA pharmacokinetics, distribution, and efficacy in vivo
7. Single intravitreal administration of a tetravalent siRNA exhibits robust and efficient gene silencing in rodent and swine photoreceptors
8. Therapeutic Oligonucleotides: An Outlook on Chemical Strategies to Improve Endosomal Trafficking
9. Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection
10. Synthesis, binding, nuclease resistance and cellular uptake properties of 2′-O-acetalester-modified oligonucleotides containing cationic groups
11. Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1
12. PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs
13. Innovative developments and emerging technologies in RNA therapeutics
14. Gene therapy with AR isoform 2 rescues spinal and bulbar muscular atrophy phenotype by modulating AR transcriptional activity
15. Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles
16. The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy
17. Diverse lipid conjugates for functional extra-hepatic siRNA deliveryin vivo
18. Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways
19. Exploring the Emergence of RNA Nucleosides and Nucleotides on the Early Earth
20. Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier
21. Optimized Cholesterol-siRNA Chemistry Improves Productive Loading onto Extracellular Vesicles
22. Hydrophobicity of Lipid-Conjugated siRNAs Predicts Productive Loading to Small Extracellular Vesicles
23. Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways
24. A 2′,2′-disulfide-bridged dinucleotide conformationally locks RNA hairpins
25. Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization Assay
26. Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-l-serine siRNA Conjugate in Mouse Brain
27. Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways.
28. Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo.
29. Lipophilic 2′-O-Acetal Ester RNAs: Synthesis, Thermal Duplex Stability, Nuclease Resistance, Cellular Uptake, and siRNA Activity after Spontaneous Naked Delivery
30. A versatile post-synthetic method on a solid support for the synthesis of RNA containing reduction-responsive modifications
31. Direct Synthesis of Partially Modified 2′-O-Pivaloyloxymethyl RNAs by a Base-Labile Protecting Group Strategy and their Potential for Prodrug-Based Gene-Silencing Applications
32. A straightforward synthesis of RNA prodrugs bearing biolabile pivaloyloxymethyl groups
33. Enhancing siRNA efficacy in vivo with extended nucleic acid backbones.
34. Single intravitreal administration of a tetravalent siRNA exhibits robust and efficient gene silencing in mouse and pig photoreceptors.
35. Single intravitreal administration of a tetravalent siRNA exhibits robust and efficient gene silencing in rodent and swine photoreceptors.
36. Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1.
37. PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs.
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