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18 results on '"Birault, Veronique"'

1. Nebulised dornase alfa reduces inflammation and improves clinical outcomes in severe COVID-19: a randomised clinical trial

Author

Porter, Joanna C., primary, Inshaw, Jamie, additional, Solis, Vincente Joel, additional, Denneny, Emma, additional, Evans, Rebecca, additional, Temkin, Mia I., additional, De Vasconcelos, Nathalia, additional, Aramburu, Iker Valle, additional, Hoving, Dennis, additional, Basire, Donna, additional, Crissell, Tracey, additional, Guinto, Jesusa, additional, Webb, Alison, additional, Esmail, Hanif, additional, Johnston, Victoria, additional, Last, Anna, additional, Rampling, Thomas, additional, Helbig, Elisa Theresa, additional, Lippert, Lena, additional, Kurth, Florian, additional, Williams, Bryan, additional, Flynn, Aiden, additional, Lukey, Pauline T, additional, Birault, Veronique, additional, and Papayannopoulos, Venizelos, additional

Published
2023
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2. Anti-inflammatory therapy with nebulised dornase alfa in patients with severe COVID-19 pneumonia A Randomised Clinical Trial

Author

Porter, Joanna C., primary, Inshaw, Jamie, additional, Solis, Vincente Joel, additional, Denneny, Emma, additional, Evans, Rebecca, additional, Temkin, Mia I., additional, De Vasconcelos, Nathalia, additional, Aramburu, Iker Valle, additional, Hoving, Dennis, additional, Basire, Donna, additional, Crissell, Tracey, additional, Guinto, Jesusa, additional, Webb, Alison, additional, Esmail, Hanif, additional, Johnston, Victoria, additional, Last, Anna, additional, Rampling, Thomas, additional, Williams, Bryan, additional, Flynn, Aiden, additional, Lukey, Pauline T, additional, Birault, Veronique, additional, and Papayannopoulos, Venizelos, additional

Published
2023
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4. Anti-inflammatory therapy with nebulised dornase alfa in patients with severe COVID-19 pneumonia

Author

Porter, Joanna, primary, Inshaw, Jamie, additional, Solis, Vincente Joel, additional, Denneny, Emma, additional, Evans, Rebecca, additional, Temkin, Mia I., additional, De Vasconcelos, Nathalia, additional, Aramburu, Iker Valle, additional, Hoving, Dennis, additional, Basire, Donna, additional, Crissell, Tracey, additional, Guinto, Jesusa, additional, Webb, Alison, additional, Esmail, Hanif, additional, Johnston, Victoria, additional, Last, Anna, additional, Rampling, Thomas, additional, Williams, Bryan, additional, Flynn, Aiden, additional, Lukey, Pauline, additional, Birault, Veronique, additional, and Papayannopoulos, Venizelos, additional

Published
2022
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5. Pulmonary Innate Lymphoid Cell Responses during Rhinovirus-induced Asthma ExacerbationsIn Vivo: A Clinical Trial

Author

Dhariwal, Jaideep, primary, Cameron, Aoife, additional, Wong, Ernie, additional, Paulsen, Malte, additional, Trujillo-Torralbo, Maria-Belen, additional, del Rosario, Ajerico, additional, Bakhsoliani, Eteri, additional, Kebadze, Tatiana, additional, Almond, Mark, additional, Farne, Hugo, additional, Gogsadze, Leila, additional, Aniscenko, Julia, additional, Rana, Batika M. J., additional, Hansel, Trevor T., additional, Jackson, David J., additional, Kon, Onn Min, additional, Edwards, Michael R., additional, Solari, Roberto, additional, Cousins, David J., additional, Walton, Ross P., additional, Johnston, Sebastian L., additional, Lavender, Paul, additional, Gould, Hannah, additional, Cousins, David, additional, van Oosterhout, Antoon J., additional, Dhariwal, Jaideep, additional, Bartlett, Nathan W., additional, Mallia, Patrick, additional, del Rosario, Jerico, additional, Smith, Janet L., additional, Edwards, Matthew J., additional, Affleck, Karen, additional, Jurdzinski, Nil Turan, additional, Birault, Veronique, additional, McErlean, Peter, additional, Wu, Yu-Chang, additional, Upton, Nadine, additional, and Jimenez, Ismael Ranz, additional

Published
2021
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6. Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein (MAP) kinase–induced inflammation

Author

Vukmanovic-Stejic, Milica, Chambers, Emma S., Suárez-Fariñas, Mayte, Sandhu, Daisy, Fuentes-Duculan, Judilyn, Patel, Neil, Agius, Elaine, Lacy, Katie E., Turner, Carolin T., Larbi, Anis, Birault, Veronique, Noursadeghi, Mahdad, Mabbott, Neil A., Rustin, Malcolm H.A., Krueger, James G., and Akbar, Arne N.

Subjects
Adult, CD4-Positive T-Lymphocytes, Male, Aging, Herpesvirus 3, Human, TRM, Resident memory T, CD8-Positive T-Lymphocytes, p38 Mitogen-Activated Protein Kinases, Article, Young Adult, CBA, Cytometric Bead Array, Humans, varicella zoster virus, Antigens, Viral, Aged, Skin, Aged, 80 and over, Inflammation, integumentary system, Interleukin-6, Tumor Necrosis Factor-alpha, p38 mitogen-activated protein kinase, Middle Aged, DC, Dendritic cell, MAP, Mitogen-activated protein, C-Reactive Protein, DEG, Differentially expressed gene, CRP, C-reactive protein, VZV, Varicella zoster virus, Female
Abstract

Background Immunity decreases with age, which leads to reactivation of varicella zoster virus (VZV). In human subjects age-associated immune changes are usually measured in blood leukocytes; however, this might not reflect alterations in tissue-specific immunity. Objectives We used a VZV antigen challenge system in the skin to investigate changes in tissue-specific mechanisms involved in the decreased response to this virus during aging. Methods We assessed cutaneous immunity based on the extent of erythema and induration after intradermal VZV antigen injection. We also performed immune histology and transcriptomic analyses on skin biopsy specimens taken from the challenge site in young (65 years) subjects. Results Old human subjects exhibited decreased erythema and induration, CD4+ and CD8+ T-cell infiltration, and attenuated global gene activation at the site of cutaneous VZV antigen challenge compared with young subjects. This was associated with increased sterile inflammation in the skin in the same subjects related to p38 mitogen-activated protein kinase–related proinflammatory cytokine production (P, Graphical abstract

Published
2018

8. Ubiquitin activation is essential for schizont maturation in Plasmodium falciparum blood-stage development

Author

Green, Judith L., primary, Wu, Yang, additional, Encheva, Vesela, additional, Lasonder, Edwin, additional, Prommaban, Adchara, additional, Kunzelmann, Simone, additional, Christodoulou, Evangelos, additional, Grainger, Munira, additional, Truongvan, Ngoc, additional, Bothe, Sebastian, additional, Sharma, Vikram, additional, Song, Wei, additional, Pinzuti, Irene, additional, Uthaipibull, Chairat, additional, Srichairatanakool, Somdet, additional, Birault, Veronique, additional, Langsley, Gordon, additional, Schindelin, Hermann, additional, Stieglitz, Benjamin, additional, Snijders, Ambrosius P., additional, and Holder, Anthony A., additional

Published
2020
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9. Synthetic studies toward pyruvate acetal containing saccharides: synthesis of the carbohydrate part of Mycobacterium smegmatis pentasaccharide glycolipid and fragments thereof for the preparation of neoantigens

Author

Ziegler, Thomas, Eckhardt, Elisabeth, and Birault, Veronique

Subjects
Organic compounds -- Synthesis, Carbohydrates -- Research, Glycosylation -- Research, Glycosides -- Research, Biological sciences, Chemistry
Abstract

Seven 4,6-O-pyruvylated D-glucosyl donors undergo glycosylation studies with methanol and methyl 2,4,6-tri-O-benzoyl-beta-D-glucopyranoside. The best yields and beta-selectivity are obtained with the trichloroacetimidate catalyzed by trimethylsilyl triflate. The studies form the basis of the synthesis of the carbohydrate moiety of the lipopentasaccharide of Mycobacterium smegmatis and its smaller fragments from pyruvylated 3-O-methyl-D-glucosyl imidate.

Published
1993

10. Enhancement of cutaneous immunity during ageing by blocking p38 MAPkinase induced inflammation

Author

Vukmanovic-Stejic, Milica, Chambers, Emma S, Farinas, Mayte Suarez, Sandhu, Daisy, Fuentes-Duculan, Judilyn, Patel, Neil, Agius, Elaine, Lacy, Katie E, Turner, Carolin T, Larbi, Anis, Birault, Veronique, Noursadeghi, Mahdad, Mabbott, Neil A, Rustin, Malcolm H A, Krueger, James, and Akbar, Arne N

Subjects
integumentary system, Journal Article
Abstract

BACKGROUND: Immunity declines with age that leads to re-activation of varicella zoster virus (VZV). In humans, age associated immune changes are usually measured in blood leukocytes however this may not reflect alterations in tissue-specific immunity.OBJECTIVES: We used a VZV antigen challenge system in the skin to investigate changes in tissue specific mechanisms involved in the decreased response to this virus during ageing.METHODS: We assessed cutaneous immunity by the extent of erythema and induration after intradermal VZV antigen injection. We also performed immune histology and transcriptomic analyses on skin biopsies taken from the site of challenge in young (65 yrs) subjects.RESULTS: Old humans exhibited decreased erythema and induration, CD4(+) and CD8(+) T cell infiltration and attenuated global gene activation at the site of cutaneous VZV antigen challenge compared to young subjects. This was associated with elevated sterile inflammation in the skin in the same subjects, related to p38 MAPK-related pro-inflammatory cytokine production (p CONCLUSION: Excessive inflammation in the skin early after antigen challenge retards antigen-specific immunity. However this can be reversed by inhibition of inflammatory cytokine production that may be utilized to promote vaccine efficacy and the treatment of infections and malignancy during ageing.

Published
2018

11. Development of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skin

Author

Smith, Susan H., primary, Peredo, Carlos E., additional, Takeda, Yukimasa, additional, Bui, Thi, additional, Neil, Jessica, additional, Rickard, David, additional, Millerman, Elizabeth, additional, Therrien, Jean-Philippe, additional, Nicodeme, Edwige, additional, Brusq, Jean-Marie, additional, Birault, Veronique, additional, Viviani, Fabrice, additional, Hofland, Hans, additional, Jetten, Anton M., additional, and Cote-Sierra, Javier, additional

Published
2016
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12. Discovery of a series of imidazopyrazine small molecule inhibitors of the kinase MAPKAPK5, that show activity using in vitro and in vivo models of rheumatoid arthritis

Author

Andrews, Martin J.I., Andrew Clase, J., Bar, Gregory, Tricarico, Giovanni, Edwards, Paul J., Brys, Reginald, Chambers, Mark, Schmidt, Wolfgang, MacLeod, Angus, Hirst, Kim, Allen, Vivienne, Birault, Veronique, Le, Joelle, Harris, John, Self, Andrew, Nash, Kevin, and Dixon, Graham

Published
2012
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18. Anti-inflammatory therapy with nebulized dornase alfa for severe COVID-19 pneumonia: a randomized unblinded trial.

Author

Porter JC, Inshaw J, Solis VJ, Denneny E, Evans R, Temkin MI, De Vasconcelos N, Aramburu IV, Hoving D, Basire D, Crissell T, Guinto J, Webb A, Esmail H, Johnston V, Last A, Rampling T, Lippert L, Helbig ET, Kurth F, Williams B, Flynn A, Lukey PT, Birault V, and Papayannopoulos V

Subjects
Humans, Male, Female, Middle Aged, Aged, Recombinant Proteins administration & dosage, Recombinant Proteins therapeutic use, Extracellular Traps drug effects, SARS-CoV-2, C-Reactive Protein analysis, C-Reactive Protein metabolism, Dexamethasone administration & dosage, Dexamethasone therapeutic use, Adult, Nebulizers and Vaporizers, Treatment Outcome, Administration, Inhalation, Deoxyribonuclease I administration & dosage, Deoxyribonuclease I therapeutic use, Anti-Inflammatory Agents administration & dosage, Anti-Inflammatory Agents therapeutic use, COVID-19 Drug Treatment, COVID-19
Abstract

Background: Prinflammatory extracellular chromatin from neutrophil extracellular traps (NETs) and other cellular sources is found in COVID-19 patients and may promote pathology. We determined whether pulmonary administration of the endonuclease dornase alfa reduced systemic inflammation by clearing extracellular chromatin., Methods: Eligible patients were randomized (3:1) to the best available care including dexamethasone (R-BAC) or to BAC with twice-daily nebulized dornase alfa (R-BAC + DA) for seven days or until discharge. A 2:1 ratio of matched contemporary controls (CC-BAC) provided additional comparators. The primary endpoint was the improvement in C-reactive protein (CRP) over time, analyzed using a repeated-measures mixed model, adjusted for baseline factors., Results: We recruited 39 evaluable participants: 30 randomized to dornase alfa (R-BAC +DA), 9 randomized to BAC (R-BAC), and included 60 CC-BAC participants. Dornase alfa was well tolerated and reduced CRP by 33% compared to the combined BAC groups (T-BAC). Least squares (LS) mean post-dexamethasone CRP fell from 101.9 mg/L to 23.23 mg/L in R-BAC +DA participants versus a 99.5 mg/L to 34.82 mg/L reduction in the T-BAC group at 7 days; p=0.01. The anti-inflammatory effect of dornase alfa was further confirmed with subgroup and sensitivity analyses on randomised participants only, mitigating potential biases associated with the use of CC-BAC participants. Dornase alfa increased live discharge rates by 63% (HR 1.63, 95% CI 1.01-2.61, p=0.03), increased lymphocyte counts (LS mean: 1.08 vs 0.87, p=0.02) and reduced circulating cf-DNA and the coagulopathy marker D-dimer (LS mean: 570.78 vs 1656.96 μg/mL, p=0.004)., Conclusions: Dornase alfa reduces pathogenic inflammation in COVID-19 pneumonia, demonstrating the benefit of cost-effective therapies that target extracellular chromatin., Funding: LifeArc, Breathing Matters, The Francis Crick Institute (CRUK, Medical Research Council, Wellcome Trust)., Clinical Trial Number: NCT04359654., Competing Interests: JP, VS, ED, RE, MT, ND, IA, DH, DB, TC, JG, AW, HE, VJ, AL, TR, LL, EH, FK, BW, VB, VP No competing interests declared, JI, AF Employee of Exploristics, PL Employee of Target to Treatment Consulting Ltd, (© 2023, Porter et al.)

Published
2024
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