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Freud's "Fragment of an Analysis of a Case of Hysteria" stands as one of his most extensive case studies, weaving together his explorations of the Oedipus complex, dream analysis, and hysteria. In this study, I propose an alternative lens through which to interpret the case: as a Bildungsroman. While ostensibly focused on Dora, the analysand, and her journey to maturity, the narrative occasionally appears to be overshadowed by Freud's own experiences and story. I contend that this overtaking of Dora's narrative is facilitated by both thematic and linguistic factors. Additionally, I examine the theme of the Oedipal complex, which intersects with a concurrent power struggle, linking it to the affective PLAY system. This system plays a role in shaping social hierarchies, internalizing group norms, delineating interpersonal boundaries, and guiding group interactions – elements intrinsically connected to the Oedipus complex. I argue that in many instances this system is used abusively "against" Dora.1 [ABSTRACT FROM AUTHOR]

Objectives: The aim of this study was to examine whether the discrepancy between participant and informant estimation of memory decline can predict MCI prognosis.Methods: Analyses involved data from individuals with MCI enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI) who filled the Everyday Cognition questionnaire. Participants who underestimated (N = 112) and overestimated (N = 157) their memory decline were compared on memory tasks, brain volume, and cerebrospinal markers, at study entry and after 24 months.Results: Individuals who underestimated their memory decline performed more poorly on memory tests, had smaller hippocampus volume, and greater Alzheimer's disease pathology than did individuals who overestimated their cognitive decline. Longitudinal comparisons demonstrated that individuals who underestimated their decline deteriorated more significantly in memory and in brain measures.Conclusions: Underestimation of memory decline should raise clinicians' suspicion of the existence of AD pathology in individuals with MCI. [ABSTRACT FROM AUTHOR]

Background: Ample evidence suggests that individuals with borderline personality disorder (BPD) exhibit hyposensitivity to pain. Since the underlying mechanism of the pain hyposensitivity is unknown, we tested here for the first time whether this hyposensitivity is pain specific or exists also for innocuous sensation, and whether it is associated with enhanced descending pain modulation capabilities.Methods: Participants were 55 women; 22 patients with BPD and 33 matched healthy controls. Testing included the measurement of warmth sensation threshold (WST), heat-pain threshold (HPT), pain adaptation, conditioned pain modulation (CPM) and temporal summation of heat-pain (TSP). The level of dissociation was also evaluated.Results: Women with BPD had higher WST and HPT compared with healthy controls. Moreover, women with BPD had greater magnitude of pain adaptation and CPM as well as higher dissociation level compared to controls. In neither the BPD nor the control group did WST and HPT correlate with pain adaptation, CPM or dissociation. In the BPD group only, HPT inversely correlated with the magnitude of TSP.Conclusions: Women with BPD present generalized hyposensitivity to both innocuous and noxious stimuli. Furthermore, women with BPD exhibit more efficient pain inhibition capabilities than healthy controls. While efficient pain modulation may underlie pain hyposensitivity in BPD, both traits may exist independently from each other, or may be moderated by another factor such as dissociation.Significance: On the basis of testing pronociceptive and antinociceptive components among individuals with BPD and healthy controls, this study reveals enhanced ability to inhibit pain among woman with borderline personality disorder (BPD) which may underlie hyposensitivity to both noxious and innocuous stimuli and perhaps also self-injurious behaviour among these individuals. The study contributes novel information on possible mechanisms involved in BPD manifestations. [ABSTRACT FROM AUTHOR]

Objectives: The aim of this study was to examine awareness of decline in memory and in language in individuals with Alzheimer's disease (AD), by comparing participant and informant ratings, as well as these ratings and actual test performance.Methods: We analyzed data from 149 individuals with AD enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI) who filled the Everyday Cognition questionnaire and performed memory and language tasks.Results: Participants provided significantly lower assessments of decline than did informants for both memory and language. There was a negative association between informant ratings and memory test scores but no association between participant ratings and memory test scores. Both participant and informant ratings correlated negatively with performance on the language tests. Informant, but not participant, ratings contributed to the prediction of one memory variable beyond demographic factors. Participant ratings contributed to the prediction of language scores beyond demographic factors more than did informant ratings.Conclusions: The findings reflect better awareness of decline in language than of decline in memory in individuals with AD. [ABSTRACT FROM AUTHOR]