1. Renal Cell Carcinoma in a Young Adult – Do We Need Further Investigations?
- Author
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Elisabeth Bruder, Stephen Wyler, Ellen C. Obermann, Matthias Walter, Svetozar Subotic, and Christian Wetterauer
- Subjects
0301 basic medicine ,Oncology ,medicine.medical_specialty ,Pathology ,Tumor suppressor gene ,Urology ,030209 endocrinology & metabolism ,030105 genetics & heredity ,urologic and male genital diseases ,03 medical and health sciences ,0302 clinical medicine ,Cigarette smoking ,Renal cell carcinoma ,Internal medicine ,medicine ,Young adult ,neoplasms ,business.industry ,medicine.disease ,Obesity ,female genital diseases and pregnancy complications ,Young age ,Biomolecular and immunohistochemistry analysis ,Male patient ,Immunohistochemistry ,business ,von Hippel-Lindau ,Young adults - Abstract
Renal cell carcinomas (RCC), mostly occurring in adults aged 60–70 years, can result from well-known factors like cigarette smoking, obesity and hypertension. However, they have been associated with genetic alterations in children and young adults. A 28 year-old male patient with a confirmed RCC underwent biomolecular and immunohistochemical analyses due to his young age. A point mutation of the von Hippel-Lindau tumor suppressor gene was identified. Young patients under 40 years with diagnosed RCC should undergo additional diagnostic investigation, hence the discovery of an underlying cause. This could be important for further treatment and counseling of these young patients.
- Published
- 2016