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The book Biochemistry and Biochemists: Who Were They and What did they Discover is a series of twenty five reviews regarding the top twenty five biochemists of the last two hundred years. The book chronicles the work and discoveries of research scientists from various parts of the world (Severo Ochoa of Spain, John Earnest Walker of Great Britain, Luis Leloir of France, Jens Skou of Denmark as well Masayusa Nomura of Japan). Some of these biochemists did foundational work (Albert Szent-Gyorgy in the realm of vitamin C) and others did exemplary work into some of the most important realms of their time (such as Dorothy Hodgkin and her explorations into the structures of penicillin and insulin). Enzyme kinetics was explored and researched by Maud Menten and Leonor Michaelis. The lives and explorations of these individuals as well as relevant anecdotes regarding their lives are explored in this book. For example, Jakub Karos Parnas, a well-known scholar and researcher died in the famous Lyubyanka Prison in Moscow, although the exact cause of his death may never be known. Luis Leloir was born in the shadow of the Arc de Triomphe in Paris and went on to achieve greatness and crucial insights in sugar metabolism and glycogen biosynthesis. Some of these researchers investigated things as simple as water (and their transporation into and out of cells) and others offered such profound ideas such as Albert Kluyver and his comments that “all organisms do biochemistry.” In a sense, all students of biochemistry as well as chemistry would do well to learn about these biochemists, their discoveries and a bit about their lives- as many led many challenging lives- such as escaping from the Germans in World War II. Each of the biochemists here in this text had something to offer the realm of science and many were rewarded with the highest honor imaginable- the Nobel Prize- and some of them succeeded in their chosen field of endeavor- even though they may have failed Anatomy and Physiology four times! Investigations into DNA, ATP and these realms also are highlighted in this book as these fundamental concepts are obviously of critical importance in the realm of biochemistry. This book is first a serious exploration into the discoveries of these biochemists while at the same time an interesting examination of the lives and loves and trials and tribulations of these biochemists who literally changed the face of biochemistry over the years.

This book is the latest volume in the highly successful series Comprehensive Biochemistry. It provides a historical and autobiographical perspective of the developments in the field through the contributions of leading individuals who reflect on their careers and their impact on biochemistry. Volume 46 is essential reading for everyone from graduate student to professor, placing in context major advances not only in biochemical terms but in relation to historical and social developments. Readers will be delighted by the lively style and the insight into the lives and careers of leading scientists of their time. - Contributors are distinguished scientists in the field - Unique series of personal recollections - Presents scientific research in a historical perspective

This book is the latest volume in the highly successful series Comprehensive Biochemistry. It provides a historical and autobiographical perspective of the developments in the field through the contributions of leading individuals who reflect on their careers and their impact on biochemistry. Volume 45 is essential reading for everyone from graduate student to professor, placing in context major advances not only in biochemical terms but in relation to historical and social developments. Readers will be delighted by the lively style and the insight into the lives and careers of leading scientists of their time.• Contributors are distinguished scientists in the field • Unique series of personal recollections • Presents scientific research in a historical perspective

This book is the latest volume in a highly successful series within Comprehensive Biochemistry and provides a historical and autobiographical perspective of the development of the field through the contributions of leading individuals who reflect on their careers and their impact on biochemistry. The book is essential reading for everybody, from graduate student to professor, placing in context major advances not only in biochemical terms but in relation to historical and social developments. Readers will be delighted by the lively style and the insight into the lives and careers of leading scientists of their time.

Les théories de l'évolution, les origines de la biologie cellulaire, celles de la biologie moléculaire et les racines du métabolisme cellulaire constituent une véritable fresque qui permet de mieux comprendre la biologie contemporaine.

Vital Forces tells the history of the'biochemical revolution', a period of unprecedentedly rapid advance in human knowledge that profoundly affected our view of life and laid the foundation for modern medicine and biotechnology. The story is told in a clear, engaging, and absorbing manner. This delightful work relates the fascinating and staggering advances in concepts and theories over the last 200 years and introduces the major figures of the times. Vital Forces also describes the discovery of the molecular basis of life through the stories of the scientists involved, including such towering figures as Louis Pasteur, Gregor Mendel, Linus Pauling, and Francis Crick. Combining science and biography into a seamless chronological narrative, the author brings to life the successes and failures, collaborations and feuds, and errors and insights that produced the revolution in biology. - Vividly describes dramatic scientific discoveries, personalities, feuds and rivalries - Answers a general readers quest to understand the nature of life, and the relevance of biochemistry/molecular biology to modern medicine, industry and agriculture

In this book a distinguished scientist-historian offers a critical account of how biochemistry and molecular biology emerged as major scientific disciplines from the interplay of chemical and biological ideas and practice. Joseph S. Fruton traces the historical development of these disciplines from antiquity to the present time, examines their institutional settings, and discusses their impact on medical, pharmaceutical, and agricultural practice.

One of the most exciting developments in biological sciences has been their merging with chemistry and physics resulting in the new disciplines of biochemistry, biophysics and molecular biology. As the developments of these new disciplines has been so rapid many of the key discoveries have occurred within the life-time of a number of prominent scientists in the field. The chapters in this and in future volumes are meant to complement with personal recollections by these scientists, the History of Biochemistry in this series (vols. 30-33 by M. Florkin and Vol. 34 by P. Laszlo). These bibliographic and autobiographic chapters convey to the reader lively, albeit at times subjective, views on both the scientific and social environments of the authors. The editor cosidered it presumptuous to give the authors narrow guidelines or to suggest changes in the chapters he received. The contributions assembled in this volume will convey the flavour of each author's particular personality.

Selected Topics in the History of Biochemistry: Personal Recollections, I presents selected topics in the history of biochemistry based on the authors'personal recollections. These topics range from the isolation of Cori ester and the discovery of sugar nucleotides to the work of Frederick Gowland Hopkins (1861-1947). Ion-coupled membrane processes are also discussed, along with fructose and fructose-2,6-bisphosphateas well as lysosomes and glycogen. Comprised of 12 chapters, this volume begins with the discovery of Cori ester and the concept of phosphorolysis before turning to the discovery of sugar nucleotides and research on ion-coupled membrane processes. The reader is then introduced to studies of fructose, fructose-2,6-bisphosphate, lysosomes, and glycogen; the contributions of Frederick Gowland Hopkins in biochemistry; and a short autobiography of Juda Hirsch Quastel, with emphasis on his research work on the concept of active centers as a possible explanation of enzyme action and his investigation of the effects of malonic acid and substituted malonic acids on bacterial dehydrogenases. The remaining chapters focus on a biochemist's approach to autopharmacology; the early development of modern protein chemistry in Uppsala, Sweden; and the biographies of two Russian scientists, A. N. Bach and Sergei E. Severin. This monograph will be of interest to students, practitioners, and researchers in the field of biochemistry.

As in Volumes 35 and 36, the chapters in this new volume complement, with personal recollections, the History of Biochemistry that was covered in the Comprehensive Biochemistry Series, Volumes 30-33 by M. Florkin and Volume 34A by P. Laszlo. The biographical and autobiographical chapters will convey to the reader a lively, albeit at times subjective, view of the scientific and social environment in which the authors have worked, resulting in new concepts and theories on the biological sciences.

The contributors to this text, who are all biochemists who worked during the 1950s and 60s, describe what appears to them to be the conceptually significant developments in biochemistry since the mid 1950s and how these were achieved. Their aim is to make their subjects intelligible to other scientists not expert in their field.

The account in this inaugural volume of the series covers the period 1900 to 1960, but also outlines the principal developments in earlier centuries from which biochemistry emerged. Findings are considered in the light of present knowledge, rather than in a rigid historical framework.

This fourth volume in the series on biochemistry looks at foundations in modern biochemistry. Topics covered include: the genetic solution; the genetic basis of development; DNA repair; evolution in an RNA world; nitrogen fixation; solute channels; viruses; biochemistry in retrospect and propspect.

This volume covers such quantum leaps in the field of biochemistry as the coding properties of DNA and the central dogma, manipulating DNA, extranuclear DNA, protein synthesis and the ribosome, and cell cycles.