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2. A stochastic least action principle applied in the description of black swan events

Author

Bufalo, Tatiana Cardoso e, Bufalo, R., de Figueiredo, Lucas P. G., Wang, Qiuping A., and Alves, F��bio L��cio

Subjects
Statistical Mechanics (cond-mat.stat-mech), FOS: Physical sciences, Condensed Matter - Statistical Mechanics
Abstract

In this paper we present a formulation of the stochastic least action principle (SAP) to encompass random movements with black swan events (of non dissipative systems) in terms of heavy tailed distributions. The black swan events are rare and drastic events, such as earthquakes and financial crisis. It has been observed that the Tsallis entropy suits well in the description of the black swan events rather than the Shannon-Boltzman-Gibbs entropy, which is intrinsically related to the fact that black swan events of physical systems are proportional to non-local correlations. As a consequence, we could assess the validity of the path probability distribution obtained using the non-additive Tsallis entropy., 12 pages, 6 figures and 2 tables

Published
2021

4. C��digo Florestal: Avalia����o 2017-2020

Author

Igari, Alexandre Toshiro, Brites, Alice, Valdiones, Ana Paula, Bertholdino Junior, Salgado, Br��gida, Vello, Bruno Grisotto, Pinto, Erika, F��bio L��cio Martins Neto, Prioste, Fernando Gallardo, Sousa, Francisco Das Chagas, Machado, Frederico, Sparovek, Gerd, Da Cruz, Isabela Patr��cia Camargo Soares, Timmers, Jean, J��ferson Da Silva Pereira, Kaline De Mello, Harfuch, Leila, Sobral, Leonardo Martin, De Barcellos, Luiza Muccillo, De Medeiros Bezerra, Marcelo Hugo, Posonski, Marcelo, Armelin, Mauro Jos�� Cap��ssoli, Costa, Mauro L��cio, Milene Maia, Machado, Patr��cia, Gasparinetti, Pedro, Feltran-Barbieri, Rafael, Guerra, Raissa, Raoni Raj��o, Giudice, Roberta Del, Milach, Simone, and Reis, Tiago

Published
2021
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6. Strangeness content of the pion in the U (3) Nambuâ€"Jonaâ€"Lasinio model.

Author

Braghin, Fábio L

Subjects
*PIONS, *COUPLING constants, *QUARK models, *QUARKS, *MESONS
Abstract

The Nambuâ€"Jonaâ€"Lasinio model is considered with flavor-dependent coupling constants G i j ( ψ ÂŻ λ i ψ) ( ψ ÂŻ λ j ψ) + ( ψ ÂŻ i Îł 5 λ i ψ) ( ψ ÂŻ i Îł 5 λ j ψ) for i , j = 0 , 1 … N f 2 âˆ' 1 , and N f = 3. A self-consistent calculation of quark effective masses and coupling constants is performed, making the strange quark effective mass vary considerably. Quantum mechanical mixings between up, down and strange constituent quarks yield a strangeness content (s-content) of the light u and d quark constituent and of the pion. Different types of estimates for the strangeness contribution for the pion mass are provided. Mixing-type interactions, G i ≠j , induce light meson mixings, and estimates for the Ď€ 0 âˆ' η and η âˆ' η ′ mixings are provided. The η âˆ' Ď€ 0 mixing is argued to be an indication of the s-content of the pion. [ABSTRACT FROM AUTHOR]

Published
2022
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7. Multicenter Initial Guidance on Use of Antivirals for Children With Coronavirus Disease 2019/Severe Acute Respiratory Syndrome Coronavirus 2

Author

Chiotos, K, Hayes, M, Kimberlin, DW, Jones, SB, James, SH, Pinninti, SG, Yarbrough, A, Abzug, MJ, MacBrayne, CE, Soma, VL, Dulek, DE, Vora, SB, Waghmare, A, Wolf, J, Olivero, R, Grapentine, S, Wattier, RL, Bio, L, Cross, SJ, Dillman, NO, Downes, KJ, Timberlake, K, Young, J, Orscheln, RC, Tamma, PD, Schwenk, HT, Zachariah, P, Aldrich, M, Goldman, DL, Groves, HE, Lamb, GS, Tribble, AC, Hersh, AL, Thorell, EA, Denison, MR, Ratner, AJ, Newland, JG, Nakamura, MM, Chiotos, K, Hayes, M, Kimberlin, DW, Jones, SB, James, SH, Pinninti, SG, Yarbrough, A, Abzug, MJ, MacBrayne, CE, Soma, VL, Dulek, DE, Vora, SB, Waghmare, A, Wolf, J, Olivero, R, Grapentine, S, Wattier, RL, Bio, L, Cross, SJ, Dillman, NO, Downes, KJ, Timberlake, K, Young, J, Orscheln, RC, Tamma, PD, Schwenk, HT, Zachariah, P, Aldrich, M, Goldman, DL, Groves, HE, Lamb, GS, Tribble, AC, Hersh, AL, Thorell, EA, Denison, MR, Ratner, AJ, Newland, JG, and Nakamura, MM

Abstract

BACKGROUND: Although coronavirus disease 2019 (COVID-19) is mild in nearly all children, a small proportion of pediatric patients develop severe or critical illness. Guidance is therefore needed regarding use of agents with potential activity against severe acute respiratory syndrome coronavirus 2 in pediatrics. METHODS: A panel of pediatric infectious diseases physicians and pharmacists from 18 geographically diverse North American institutions was convened. Through a series of teleconferences and web-based surveys, a set of guidance statements was developed and refined based on review of best available evidence and expert opinion. RESULTS: Given the typically mild course of pediatric COVID-19, supportive care alone is suggested for the overwhelming majority of cases. The panel suggests a decision-making framework for antiviral therapy that weighs risks and benefits based on disease severity as indicated by respiratory support needs, with consideration on a case-by-case basis of potential pediatric risk factors for disease progression. If an antiviral is used, the panel suggests remdesivir as the preferred agent. Hydroxychloroquine could be considered for patients who are not candidates for remdesivir or when remdesivir is not available. Antivirals should preferably be used as part of a clinical trial if available. CONCLUSIONS: Antiviral therapy for COVID-19 is not necessary for the great majority of pediatric patients. For those rare cases of severe or critical disease, this guidance offers an approach for decision-making regarding antivirals, informed by available data. As evidence continues to evolve rapidly, the need for updates to the guidance is anticipated.

Published
2020

8. Evolutionary framework for two-stage stochastic resource allocation problems

Author

Hokama, Pedro H. D. B., Felice, M��rio C. San, Bracht, Evandro C., and Usberti, F��bio L.

Subjects
FOS: Computer and information sciences, Artificial Intelligence (cs.AI), Computer Science - Artificial Intelligence, Computer Science - Neural and Evolutionary Computing, Neural and Evolutionary Computing (cs.NE)
Abstract

Resource allocation problems are a family of problems in which resources must be selected to satisfy given demands. This paper focuses on the two-stage stochastic generalization of resource allocation problems where future demands are expressed in a finite number of possible scenarios. The goal is to select cost effective resources to be acquired in the present time (first stage), and to implement a complete solution for each scenario (second stage), while minimizing the total expected cost of the choices in both stages. We propose an evolutionary framework for solving general two-stage stochastic resource allocation problems. In each iteration of our framework, a local search algorithm selects resources to be acquired in the first stage. A genetic metaheuristic then completes the solutions for each scenario and relevant information is passed onto the next iteration, thereby supporting the acquisition of promising resources in the following first stage. Experimentation on numerous instances of the two-stage stochastic Steiner tree problem suggests that our evolutionary framework is powerful enough to address large instances of a wide variety of two-stage stochastic resource allocation problems.

Published
2018

10. Low energy constituent quark and pion effective couplings to external electromagnetic field and a weak magnetic field

Author

Braghin, F��bio L.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Phenomenology (hep-ph), High Energy Physics::Lattice, High Energy Physics::Phenomenology, Nuclear Theory, FOS: Physical sciences
Abstract

In this work, a compilation of effective electromagnetic field couplings to pions and constituent quarks and their effective interactions derived previously, including corrections to the NJL model, is presented. The particular case of a weak external magnetic field along the $\hat{z}$ direction is considered shortly and effective coupling constants are redefined to incorporate the weak-$B_0$ dependence. They correspond to corrections to well known pion-constituent quark couplings and to the NJL and vector NJL effective couplings that break isospin and chiral symmetries., 4 pages, work presented by F.L.B, at the XIV International Workshop on Hadron Physics, Florianopolis, Brazil, March 2018

Published
2018

13. Pelagiidae Gegenbaur 1856

Author

Morandini, Andr�� C., Da, F��bio L., Silveira, and Cornelius, Paul F. S.

Subjects
Cnidaria, Pelagiidae, Scyphozoa, Semaeostomeae, Animalia, Biodiversity, Taxonomy
Abstract

Family Pelagiidae Gegenbaur, 1856 Scyphomedusae with eight or 16 marginal sense organs (rhopalia); adults with tentacles on umbrella margin located in clefts between the marginal lappets; with gastrovascular space divided by radial septa into separate unbranched stomach pouches; without ring canal; having oral arms elongate and folded (Mayer, 1910; Kramp, 1961; Russell, 1970; Mianzan and Cornelius, 1999)., Published as part of Morandini, Andr�� C., Da, F��bio L., Silveira & Cornelius, Paul F. S., 2006, Redescription of Chrysaora lactea Eschscholtz, 1829 (Cnidaria, Scyphozoa) from the Brazilian coast, with designation of a neotype, pp. 29-48 in Zootaxa 1135 on page 31, DOI: 10.5281/zenodo.171956, {"references":["Mayer, A. G. (1910) The medusae of the world III. The scyphomedusae. Carnegie Institution, Washington D. C., pp. 499 - 735.","Kramp, P. L. (1961) Synopsis of the medusae of the world. Journal of the Marine Biological Association of the United Kingdom, 40, 1 - 469.","Russell, F. S. (1970) The medusae of the British Isles II. Pelagic Scyphozoa with a supplement to the first volume on hydromedusae. Cambridge University Press, Cambridge, 284 pp.","Mianzan, H. W. & Cornelius, P. F. S. (1999) Cubomedusae and Scyphomedusae. In: Boltovskoy, D. (Ed.), South Atlantic Zooplankton, Vol. I. Backhuys Publishers, Leiden, pp. 513 - 559."]}

Published
2006
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15. Créer des variétés de cotonniers avec des agriculteurs du Bénin : premiers résultats d'une sélection participative

Author

Djaboutou, Mossibaou, Lewicki, Sylvie, Sêkloka, Emmanuel, Takpara, Daouda, Assogba, Luc, Orou, B.I., Bio, L., and Lançon, Jacques

Subjects
Gossypium, Expérimentation au champ, Sélection, Participation, E50 - Sociologie rurale, Méthode d'amélioration génétique, F30 - Génétique et amélioration des plantes
Abstract

La sélection participative (SP) du cotonnier a été initiée au Bénin comme un moyen de favoriser le rapprochement des agriculteurs, producteurs de coton, et les chercheurs grâce à la gestion commune d'un dispositif d'expérimentation. Elle a débuté en 1996 par la création d'une population panmictique dont un échantillon a été remis à trois paysans dont les champs sont situés dans des zones agro-climatiques contrastées. Ceux-ci ont effectué deux cycles de sélection en 1997 et 1998. Parallèlement, les chercheurs ont aussi réalisé une sélection à partir de la même population source dans le Centre permanent d'expérimentation d'Okpara. Les populations sélectionnées ont été évaluées et comparées en 1998 à la population source et au témoin cultivé, la variété STAM 18A. Les tests comparatifs sont conduits dans quatre centres permanents d'expérimentation proches des zones dans lesquelles la sélection a été réalisée. Le nord du Bénin a bénéficié d'une pluviométrie normale tandis que le centre a connu un arrêt prématuré des précipitations en fin de campagne. Les observations portent sur les caractéristiques morphologiques et agronomiques. Le pool génétique de départ (et ses re-sélections) parait un peu plus productif et un peu plus précoce que le témoin. Ses capsules sont plus grosses bien que sa charge en capsules paraisse un peu plus faible. Avec les dispositifs (méthode, effectifs et pression de sélection) utilisés et après deux cycles, les producteurs-sélectionneurs aboutissent à un progrès génétique faible en matière de productivité, bien que tout à fait comparable à celui obtenu par les chercheurs. With the protocols used (methods, numbers and selection pressure) and after two cycles, the producers-breeders achieved only poor genetic progress in terms of productivity, though comparable to that obtained by researchers.

Published
2004

16. Space-time evolution of the \lap model: classical and quantum aspects

Author

Braghin, F��bio L. and Navarra, Fernando S.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Phenomenology (hep-ph), FOS: Physical sciences
Abstract

A time dependent variational approach is used to derive the equations of motion for the \lambda \phi^4 model. The simultaneous evolution of the quantum fluctuations and of the classical part of the field is considered in a lattice of 1+1 dimensions. Different initial conditions corresponding to non equilibrium situations are considered and evolved in time. Such high energy localized configurations expand in the lattice by ``bumps'' which may change with time. The quantum fluctuations make the peaks be smoother and the expansion faster., Comment: 12 pages latex plus five figures .eps. Report:1460/2001IF-USP

Published
2001

25. Immediate effects of TENS and cryotherapy in the reflex excitability and voluntary activity in hemiparetic subjects: a randomized crossover trial.

Author

Martins, Fábio L., Carvalho, Luis C., Silva, Cassiane C., Brasileiro, Jamilson S., Souza, Túlio O., and R. Lindquist, Ana R.

Abstract

Background: The disorder of reflex and motor function in patients affected by stroke causes negative impact on the performance of movement patterns and affects the functional activities. Objectives: To investigate the immediate effects of transcutaneous electrical nerve stimulation (TENS) and cryotherapy interventions on the spinal reflex excitability and in the voluntary electromyography (EMG) activity in people with chronic stroke. Method: Randomized crossover trial. The maximum H-reflex (Hmax), the H-reflex latency and the maximum motor response (Mmax) of the soleus muscle and also the EMG of the tibialis muscle where evaluated before and after the application of TENS, cryotherapy and control conditions. Results: The Hmax/Mmax ratio was statistically significant higher (p=0.0245) and the H-reflex latency was statistically significant lower (p=0.0375) in the soleus muscle of the affected limb. The EMG amplitude of the tibialis anterior was reduced in the compromised limb (p<0.0001). After the use of the TENS, a reduction in the Hmax/Mmax ratio (p=0.0006) was observed leading to lower reflex excitability. However, after the cryotherapy intervention an increase of the Hmax/Mmax ratio was observed, which was accompanied by an increase in the H-reflex latency (p=0.0001). The EMG amplitude has not changed by any of the interventions. Conclusions: Our findings suggest that TENS may be a choice for immediate reduction of reflex excitability, whereas cryotherapy intervention may increase reflex excitability in hemiparetic subjects. However, none of the changes mediated by either intervention were able to modify the electrical activity in the antagonist muscle of the spastic muscle. This trial was registered in the Australian New Zealand Clinical Trials Registry (ANZCTR) - ACTRN12610000302055. [ABSTRACT FROM AUTHOR]

Published
2012

27. Search for dark matter produced in association with a Higgs boson decaying to $\gamma\gamma$ or $\tau^+\tau^-$ at $\sqrt{s} =$ 13 TeV

Author

Sirunyan, Albert M., Tumasyan, Armen, Adam, Wolfgang, Ambrogi, Federico, Asilar, Ece, Bergauer, Thomas, Brandstetter, Johannes, Dragicevic, Marko, Er�, Janos, Escalante Del Valle, Alberto, Flechl, Martin, Fruehwirth, Rudolf, Ghete, Vasile Mihai, Hrubec, Josef, Jeitler, Manfred, Krammer, Natascha, Kr�Tschmer, Ilse, Liko, Dietrich, Madlener, Thomas, Mikulec, Ivan, Rad, Navid, Rohringer, Herbert, Schieck, Jochen, Sch�Fbeck, Robert, Spanring, Markus, Spitzbart, Daniel, Taurok, Anton, Waltenberger, Wolfgang, Wittmann, Johannes, Wulz, Claudia-Elisabeth, Zarucki, Mateusz, Chekhovsky, Vladimir, Mossolov, Vladimir, Gonzalez, Juan Suarez, De Wolf, Eddi A., Di Croce, Davide, Janssen, Xavier, Lauwers, Jasper, Pieters, Maxim, Van De Klundert, Merijn, Van Haevermaet, Hans, Van Mechelen, Pierre, Van Remortel, Nick, Abu Zeid, Shimaa, Blekman, Freya, D'Hondt, Jorgen, De Bruyn, Isabelle, De Clercq, Jarne, Deroover, Kevin, Flouris, Giannis, Lontkovskyi, Denys, Lowette, Steven, Marchesini, Ivan, Moortgat, Seth, Moreels, Lieselotte, Python, Quentin, Skovpen, Kirill, Tavernier, Stefaan, Van Doninck, Walter, Van Mulders, Petra, Van Parijs, Isis, Beghin, Diego, Bilin, Bugra, Brun, Hugues, Clerbaux, Barbara, De Lentdecker, Gilles, Delannoy, Hugo, Dorney, Brian, Fasanella, Giuseppe, Favart, Laurent, Goldouzian, Reza, Grebenyuk, Anastasia, Kalsi, Amandeep Kaur, Lenzi, Thomas, Luetic, Jelena, Postiau, Nicolas, Starling, Elizabeth, Thomas, Laurent, Vander Velde, Catherine, Vanlaer, Pascal, Vannerom, David, Wang, Qun, Cornelis, Tom, Dobur, Didar, Fagot, Alexis, Gul, Muhammad, Khvastunov, Illia, Poyraz, Deniz, Roskas, Christos, Trocino, Daniele, Tytgat, Michael, Verbeke, Willem, Vermassen, Basile, Vit, Martina, Zaganidis, Nicolas, Bakhshiansohi, Hamed, Bondu, Olivier, Brochet, S�Bastien, Bruno, Giacomo, Caputo, Claudio, David, Pieter, Delaere, Christophe, Delcourt, Martin, Francois, Brieuc, Giammanco, Andrea, Krintiras, Georgios, Lemaitre, Vincent, Magitteri, Alessio, Mertens, Alexandre, Musich, Marco, Piotrzkowski, Krzysztof, Saggio, Alessia, Vidal Marono, Miguel, Wertz, S�Bastien, Zobec, Joze, Alves, F�Bio L�Cio, Alves, Gilvan, Brito, Lucas, Correa Martins Junior, Marcos, Correia Silva, Gilson, Hensel, Carsten, Moraes, Arthur, Pol, Maria Elena, Rebello Teles, Patricia, Belchior Batista Das Chagas, Ewerton, Carvalho, Wagner, Chinellato, Jose, Coelho, Eduardo, Melo Da Costa, Eliza, Da Silveira, Gustavo Gil, De Jesus Damiao, Dilson, De Oliveira Martins, Carley, Fonseca De Souza, Sandro, Malbouisson, Helena, Figueiredo, Diego Matos, Melo De Almeida, Miqueias, Mora Herrera, Clemencia, Mundim, Luiz, Nogima, Helio, Prado Da Silva, Wanda Lucia, Sanchez Rosas, Luis Junior, Santoro, Alberto, Sznajder, Andre, Thiel, Mauricio, Manganote, Edmilson Jos� Tonelli, Torres Da Silva De Araujo, Felipe, Vilela Pereira, Antonio, Ahuja, Sudha, Bernardes, Cesar Augusto, Calligaris, Luigi, Tomei, Thiago, De Moraes Gregores, Eduardo, Mercadante, Pedro G., Novaes, Sergio F., Padula, Sandra, Abad, David Romero, Aleksandrov, Aleksandar, Hadjiiska, Roumyana, Iaydjiev, Plamen, Marinov, Andrey, Misheva, Milena, Rodozov, Mircho, Shopova, Mariana, Sultanov, Georgi, Dimitrov, Anton, Litov, Leander, Pavlov, Borislav, Petkov, Peicho, Fang, Wenxing, Gao, Xuyang, Yuan, Li, Ahmad, Muhammad, Bian, Jian-Guo, Chen, Guo-Ming, Chen, He-Sheng, Chen, Mingshui, Chen, Ye, Jiang, Chun-Hua, Leggat, Duncan, Liao, Hongbo, Liu, Zhenan, Romeo, Francesco, Shaheen, Sarmad Masood, Spiezia, Aniello, Tao, Junquan, Wang, Chunjie, Wang, Zheng, Yazgan, Efe, Zhang, Huaqiao, Zhao, Jingzhou, Ban, Yong, Chen, Geng, Levin, Andrew, Li, Jing, Li, Linwei, Li, Qiang, Mao, Yajun, Qian, Si-Jin, Wang, Dayong, Xu, Zijun, Wang, Yi, Avila, Carlos, Cabrera, Andr�S, Carrillo Montoya, Camilo Andres, Chaparro Sierra, Luisa Fernanda, Florez, Carlos, Hern�Ndez, Carlos Felipe Gonz�Lez, Segura Delgado, Manuel Alejandro, Courbon, Benoit, Godinovic, Nikola, Lelas, Damir, Puljak, Ivica, Sculac, Toni, Antunovic, Zeljko, Kovac, Marko, Brigljevic, Vuko, Ferencek, Dinko, Kadija, Kreso, Mesic, Benjamin, Starodumov, Andrei, Susa, Tatjana, Ather, Mohsan Waseem, Attikis, Alexandros, Kolosova, Marina, Mavromanolakis, Georgios, Mousa, Jehad, Nicolaou, Charalambos, Ptochos, Fotios, Razis, Panos A., Rykaczewski, Hans, Finger, Miroslav, Finger, Michael, Ayala, Edy, Carrera Jarrin, Edgar, Assran, Yasser, Elgammal, Sherif, Khalil, Shaaban, Bhowmik, Sandeep, Carvalho Antunes De Oliveira, Alexandra, Dewanjee, Ram Krishna, Ehataht, Karl, Kadastik, Mario, Raidal, Martti, Veelken, Christian, Eerola, Paula, Kirschenmann, Henning, Pekkanen, Juska, Voutilainen, Mikko, Havukainen, Joona, Heikkil�, Jaana Kristiina, Jarvinen, Terhi, Karim�Ki, Veikko, Kinnunen, Ritva, Lamp�N, Tapio, Lassila-Perini, Kati, Laurila, Santeri, Lehti, Sami, Lind�N, Tomas, Luukka, Panja-Riina, M�Enp��, Teppo, Siikonen, Hannu, Tuominen, Eija, Tuominiemi, Jorma, Tuuva, Tuure, Besancon, Marc, Couderc, Fabrice, Dejardin, Marc, Denegri, Daniel, Faure, Jean-Louis, Ferri, Federico, Ganjour, Serguei, Givernaud, Alain, Gras, Philippe, Hamel De Monchenault, Gautier, Jarry, Patrick, Leloup, Cl�Ment, Locci, Elizabeth, Malcles, Julie, Negro, Giulia, Rander, John, Rosowsky, Andr�, Sahin, Mehmet �Zg�R, Titov, Maksym, Abdulsalam, Abdulla, Amendola, Chiara, Antropov, Iurii, Beaudette, Florian, Busson, Philippe, Charlot, Claude, Granier De Cassagnac, Raphael, Kucher, Inna, Lisniak, Stanislav, Lobanov, Artur, Martin Blanco, Javier, Nguyen, Matthew, Ochando, Christophe, Ortona, Giacomo, Pigard, Philipp, Salerno, Roberto, Sauvan, Jean-Baptiste, Sirois, Yves, Stahl Leiton, Andre Govinda, Zabi, Alexandre, Zghiche, Amina, Agram, Jean-Laurent, Andrea, Jeremy, Bloch, Daniel, Brom, Jean-Marie, Chabert, Eric Christian, Cherepanov, Vladimir, Collard, Caroline, Conte, Eric, Fontaine, Jean-Charles, Gel�, Denis, Goerlach, Ulrich, Jansov�, Mark�Ta, Le Bihan, Anne-Catherine, Tonon, Nicolas, Van Hove, Pierre, Gadrat, S�Bastien, Beauceron, Stephanie, Bernet, Colin, Boudoul, Gaelle, Chanon, Nicolas, Chierici, Roberto, Contardo, Didier, Depasse, Pierre, El Mamouni, Houmani, Fay, Jean, Finco, Linda, Gascon, Susan, Gouzevitch, Maxime, Grenier, G�Rald, Ille, Bernard, Lagarde, Francois, Laktineh, Imad Baptiste, Lattaud, Hugues, Lethuillier, Morgan, Mirabito, Laurent, Pequegnot, Anne-Laure, Perries, Stephane, Popov, Andrey, Sordini, Viola, Vander Donckt, Muriel, Viret, S�Bastien, Zhang, Sijing, Khvedelidze, Arsen, Tsamalaidze, Zviad, Autermann, Christian Tobias, Feld, Lutz Werner, Kiesel, Maximilian Knut, Klein, Katja, Lipinski, Martin, Preuten, Marius, Rauch, Max Philip, Schomakers, Christian, Schulz, Johannes, Teroerde, Marius, Wittmer, Bruno, Zhukov, Valery, Albert, Andreas, Duchardt, Deborah, Endres, Matthias, Erdmann, Hans Martin, Esch, Thomas, Fischer, Robert, Ghosh, Saranya, G�Th, Andreas, Hebbeker, Thomas, Heidemann, Carsten Andreas, Hoepfner, Kerstin, Keller, Henning, Knutzen, Simon, Mastrolorenzo, Luca, Merschmeyer, Markus, Meyer, Arnd, Millet, Philipp, Mukherjee, Swagata, Pook, Tobias, Radziej, Markus, Reithler, Hans, Rieger, Marcel, Scheuch, Florian, Schmidt, Alexander, Teyssier, Daniel, Fl�Gge, G�Nter, Hlushchenko, Olena, Kargoll, Bastian, Kress, Thomas, Künsken, Andreas, M�Ller, Thomas, Nehrkorn, Alexander Rafael Maria, Nowack, Andreas, Pistone, Claudia, Pooth, Oliver, Sert, Hale, Stahl, Achim, Aldaya Martin, Maria, Arndt, Till, Asawatangtrakuldee, Chayanit, Babounikau, Illia, Beernaert, Kelly, Behnke, Olaf, Behrens, Ulf, Mart�Nez, Armando Berm�Dez, Bertsche, David, Bin Anuar, Afiq Aizuddin, Borras, Kerstin, Botta, Valeria, Campbell, Alan, Connor, Patrick, Contreras-Campana, Christian, Costanza, Francesco, Danilov, Vladyslav, De Wit, Adinda, Defranchis, Matteo Maria, Diez Pardos, Carmen, Damiani, Daniela Dom�Nguez, Eckerlin, Guenter, Eichhorn, Thomas, Elwood, Adam, Eren, Engin, Gallo, Elisabetta, Geiser, Achim, Grados Luyando, Juan Manuel, Grohsjean, Alexander, Gunnellini, Paolo, Guthoff, Moritz, Haranko, Mykyta, Harb, Ali, Hauk, Johannes, Jung, Hannes, Kasemann, Matthias, Keaveney, James, Kleinwort, Claus, Knolle, Joscha, Kr�Cker, Dirk, Lange, Wolfgang, Lelek, Aleksandra, Lenz, Teresa, Lipka, Katerina, Lohmann, Wolfgang, Mankel, Rainer, Melzer-Pellmann, Isabell-Alissandra, Meyer, Andreas Bernhard, Meyer, Mareike, Missiroli, Marino, Mittag, Gregor, Mnich, Joachim, Myronenko, Volodymyr, Pflitsch, Svenja Karen, Pitzl, Daniel, Raspereza, Alexei, Savitskyi, Mykola, Saxena, Pooja, Sch�Tze, Paul, Schwanenberger, Christian, Shevchenko, Rostyslav, Singh, Akshansh, Stefaniuk, Nazar, Tholen, Heiner, Turkot, Oleksii, Vagnerini, Antonio, Van Onsem, Gerrit Patrick, Walsh, Roberval, Wen, Yiwen, Wichmann, Katarzyna, Wissing, Christoph, Zenaiev, Oleksandr, Aggleton, Robin, Bein, Samuel, Benato, Lisa, Benecke, Anna, Blobel, Volker, Centis Vignali, Matteo, Dreyer, Torben, Garutti, Erika, Gonzalez, Daniel, Haller, Johannes, Hinzmann, Andreas, Karavdina, Anastasia, Kasieczka, Gregor, Klanner, Robert, Kogler, Roman, Kovalchuk, Nataliia, Kurz, Simon, Kutzner, Viktor, Lange, Johannes, Marconi, Daniele, Multhaup, Jens, Niedziela, Marek, Nowatschin, Dominik, Perieanu, Adrian, Reimers, Arne, Rieger, Oliver, Scharf, Christian, Schleper, Peter, Schumann, Svenja, Schwandt, Joern, Sonneveld, Jory, Stadie, Hartmut, Steinbr�Ck, Georg, Stober, Fred-Markus Helmut, St�Ver, Marc, Troendle, Daniel, Vanhoefer, Annika, Vormwald, Benedikt, Akbiyik, Melike, Barth, Christian, Baselga, Marta, Baur, Sebastian, Butz, Erik, Caspart, Ren�, Chwalek, Thorsten, Colombo, Fabio, De Boer, Wim, Dierlamm, Alexander, Faltermann, Nils, Freund, Benedikt, Giffels, Manuel, Harrendorf, Marco Alexander, Hartmann, Frank, Heindl, Stefan Michael, Husemann, Ulrich, Kassel, Florian, Katkov, Igor, Kudella, Simon, Mildner, Hannes, Mitra, Soureek, Mozer, Matthias Ulrich, Plagge, Michael, Quast, Gunter, Rabbertz, Klaus, Schr�Der, Matthias, Shvetsov, Ivan, Sieber, Georg, Simonis, Hans-J�Rgen, Ulrich, Ralf, Wayand, Stefan, Weber, Marc, Weiler, Thomas, Williamson, Shawn, W�Hrmann, Clemens, Wolf, Roger, Anagnostou, Georgios, Daskalakis, Georgios, Geralis, Theodoros, Kyriakis, Aristotelis, Loukas, Demetrios, Paspalaki, Garyfallia, Topsis-Giotis, Iasonas, Karathanasis, George, Kesisoglou, Stilianos, Kontaxakis, Pantelis, Panagiotou, Apostolos, Saoulidou, Niki, Tziaferi, Eirini, Vellidis, Konstantinos, Kousouris, Konstantinos, Papakrivopoulos, Ioannis, Tsipolitis, Georgios, Evangelou, Ioannis, Foudas, Costas, Gianneios, Paraskevas, Katsoulis, Panagiotis, Kokkas, Panagiotis, Mallios, Stavros, Manthos, Nikolaos, Papadopoulos, Ioannis, Paradas, Evangelos, Strologas, John, Triantis, Frixos A., Tsitsonis, Dimitrios, Bart�K, M�Rton, Csanad, Mate, Filipovic, Nicolas, Major, P�Ter, Nagy, Marton Imre, Pasztor, Gabriella, Sur�Nyi, Oliv�R, Veres, Gabor Istvan, Bencze, Gyorgy, Hajdu, Csaba, Horvath, Dezso, Hunyadi, �D�M, Sikler, Ferenc, V�Mi, Tam�S �Lmos, Veszpremi, Viktor, Vesztergombi, Gyorgy, Beni, Noemi, Czellar, Sandor, Karancsi, J�Nos, Makovec, Alajos, Molnar, Jozsef, Szillasi, Zoltan, Raics, Peter, Trocsanyi, Zoltan Laszlo, Ujvari, Balazs, Choudhury, Somnath, Komaragiri, Jyothsna Rani, Tiwari, Praveen Chandra, Bahinipati, Seema, Kar, Chandiprasad, Mal, Prolay, Mandal, Koushik, Nayak, Aruna, Sahoo, Deepak Kumar, Swain, Sanjay Kumar, Bansal, Sunil, Beri, Suman Bala, Bhatnagar, Vipin, Chauhan, Sushil, Chawla, Ridhi, Dhingra, Nitish, Gupta, Rajat, Kaur, Anterpreet, Kaur, Amandeep, Kaur, Manjit, Kaur, Sandeep, Kumar, Ramandeep, Kumari, Priyanka, Lohan, Manisha, Mehta, Ankita, Sandeep, Kaur, Sharma, Sandeep, Singh, Jasbir, Walia, Genius, Bhardwaj, Ashutosh, Choudhary, Brajesh C., Garg, Rocky Bala, Gola, Mohit, Keshri, Sumit, Kumar, Ashok, Malhotra, Shivali, Naimuddin, Md, Priyanka, Priyanka, Ranjan, Kirti, Shah, Aashaq, Sharma, Ramkrishna, Bhardwaj, Rishika, Bharti, Monika, Bhattacharya, Rajarshi, Bhattacharya, Satyaki, Bhawandeep, Bhawandeep, Bhowmik, Debabrata, Dey, Sourav, Dutt, Suneel, Dutta, Suchandra, Ghosh, Shamik, 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Batool, Zeinali, Maryam, Felcini, Marta, Grunewald, Martin, Abbrescia, Marcello, Calabria, Cesare, Colaleo, Anna, Creanza, Donato, Cristella, Leonardo, De Filippis, Nicola, De Palma, Mauro, Di Florio, Adriano, Errico, Filippo, Fiore, Luigi, Gelmi, Andrea, Iaselli, Giuseppe, Ince, Merve, Lezki, Samet, Maggi, Giorgio, Maggi, Marcello, Miniello, Giorgia, My, Salvatore, Nuzzo, Salvatore, Pompili, Alexis, Pugliese, Gabriella, Radogna, Raffaella, Ranieri, Antonio, Selvaggi, Giovanna, Sharma, Archana, Silvestris, Lucia, Venditti, Rosamaria, Verwilligen, Piet, Zito, Giuseppe, Abbiendi, Giovanni, Battilana, Carlo, Bonacorsi, Daniele, Borgonovi, Lisa, Braibant-Giacomelli, Sylvie, Campanini, Renato, Capiluppi, Paolo, Castro, Andrea, Cavallo, Francesca Romana, Chhibra, Simranjit Singh, Ciocca, Claudia, Codispoti, Giuseppe, Cuffiani, Marco, Dallavalle, Gaetano-Marco, Fabbri, Fabrizio, Fanfani, Alessandra, Giacomelli, Paolo, Grandi, Claudio, Guiducci, Luigi, Iemmi, Fabio, Marcellini, Stefano, 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Tabarelli De Fatis, Tommaso, Buontempo, Salvatore, Cavallo, Nicola, Di Crescenzo, Antonia, Fabozzi, Francesco, Fienga, Francesco, Galati, Giuliana, Iorio, Alberto Orso Maria, Khan, Wajid Ali, Lista, Luca, Meola, Sabino, Paolucci, Pierluigi, Sciacca, Crisostomo, Voevodina, Elena, Azzi, Patrizia, Bacchetta, Nicola, Bisello, Dario, Boletti, Alessio, Bragagnolo, Alberto, Carlin, Roberto, Checchia, Paolo, Dall'Osso, Martino, De Castro Manzano, Pablo, Dorigo, Tommaso, Dosselli, Umberto, Gasparini, Fabrizio, Gasparini, Ugo, Gozzelino, Andrea, Lacaprara, Stefano, Lujan, Paul, Margoni, Martino, Meneguzzo, Anna Teresa, Pazzini, Jacopo, Ronchese, Paolo, Rossin, Roberto, Simonetto, Franco, Tiko, Andres, Torassa, Ezio, Zanetti, Marco, Zotto, Pierluigi, Zumerle, Gianni, Braghieri, Alessandro, Magnani, Alice, Montagna, Paolo, Ratti, Sergio P., Re, Valerio, Ressegotti, Martina, Riccardi, Cristina, Salvini, Paola, Vai, Ilaria, Vitulo, Paolo, Alunni Solestizi, Luisa, Biasini, Maurizio, Bilei, Gian 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Ramirez-Sanchez, Gabriel, Reyes-Almanza, Rogelio, Hern�Ndez, Alberto S�Nchez, Carrillo Moreno, Salvador, Oropeza Barrera, Cristina, Valencia, Fabiola Vazquez, Eysermans, Jan, Pedraza, Isabel, Ibarguen, Humberto Antonio Salazar, Estrada, Cecilia Uribe, Morelos Pineda, Antonio, Krofcheck, David, Bheesette, Srinidhi, Butler, Philip H., Ahmad, Ashfaq, Asghar, Muhammad Irfan, Hassan, Qamar, Hoorani, Hafeez R., Qazi, Shamona, Shah, Mehar Ali, Shoaib, Muhammad, Waqas, Muhammad, Bialkowska, Helena, Bluj, Michal, Boimska, Bozena, Frueboes, Tomasz, G�Rski, Maciej, Kazana, Malgorzata, Nawrocki, Krzysztof, Szleper, Michal, Traczyk, Piotr, Zalewski, Piotr, Bunkowski, Karol, Byszuk, Adrian, Doroba, Krzysztof, Kalinowski, Artur, Konecki, Marcin, Krolikowski, Jan, Misiura, Maciej, Olszewski, Michal, Pyskir, Andrzej, Walczak, Marek, Bargassa, Pedrame, Da Cruz E Silva, Crist�V�O Beir�O, Di Francesco, Agostino, Faccioli, Pietro, Galinhas, Bruno, Gallinaro, Michele, Hollar, Jonathan, Leonardo, Nuno, 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M., Kilpatrick, Matthew, Li, Wei, Michlin, Benjamin, Padley, Brian Paul, Roberts, Jay, Rorie, Jamal, Shi, Wei, Tu, Zhoudunming, Zabel, James, Zhang, Aobo, Bodek, Arie, De Barbaro, Pawel, Demina, Regina, Duh, Yi-Ting, Dulemba, Joseph Lynn, Fallon, Colin, Ferbel, Thomas, Galanti, Mario, Garcia-Bellido, Aran, Han, Jiyeon, Hindrichs, Otto, Khukhunaishvili, Aleko, Lo, Kin Ho, Tan, Ping, Taus, Rhys, Verzetti, Mauro, Agapitos, Antonis, Chou, John Paul, Gershtein, Yuri, Espinosa, Tirso Alejandro G�Mez, Halkiadakis, Eva, Heindl, Maximilian, Hughes, Elliot, Kaplan, Steven, Kunnawalkam Elayavalli, Raghav, Kyriacou, Savvas, Lath, Amitabh, Montalvo, Roy, Nash, Kevin, Osherson, Marc, Saka, Halil, Salur, Sevil, Schnetzer, Steve, Sheffield, David, Somalwar, Sunil, Stone, Robert, Thomas, Scott, Thomassen, Peter, Walker, Matthew, Delannoy, Andr�S G., Heideman, Joseph, Riley, Grant, Rose, Keith, Spanier, Stefan, Thapa, Krishna, Bouhali, Othmane, Celik, Ali, Dalchenko, Mykhailo, De Mattia, Marco, Delgado, Andrea, Dildick, Sven, Eusebi, Ricardo, Gilmore, Jason, Huang, Tao, Kamon, Teruki, Luo, Sifu, Mueller, Ryan, Pakhotin, Yuriy, Patel, Rishi, Perloff, Alexx, Perni�, Luca, Rathjens, Denis, Safonov, Alexei, Tatarinov, Aysen, Akchurin, Nural, Damgov, Jordan, De Guio, Federico, Dudero, Phillip Russell, Kunori, Shuichi, Lamichhane, Kamal, Lee, Sung Won, Mengke, Tielige, Muthumuni, Samila, Peltola, Timo, Undleeb, Sonaina, Volobouev, Igor, Wang, Zhixing, Greene, Senta, Gurrola, Alfredo, Janjam, Ravi, Johns, Willard, Maguire, Charles, Melo, Andrew, Ni, Hong, Padeken, Klaas, Alvarez, Jos� David Ruiz, Sheldon, Paul, Tuo, Shengquan, Velkovska, Julia, Verweij, Marta, Xu, Qiao, Arenton, Michael Wayne, Barria, Patrizia, Cox, Bradley, Hirosky, Robert, Joyce, Matthew, Ledovskoy, Alexander, Li, Hengne, Neu, Christopher, Sinthuprasith, Tutanon, Wang, Yanchu, Wolfe, Evan, Xia, Fan, Harr, Robert, Karchin, Paul Edmund, Poudyal, Nabin, Sturdy, Jared, Thapa, Prakash, Zaleski, Shawn, Brodski, Michael, Buchanan, James, Caillol, C�Cile, Carlsmith, Duncan, Dasu, Sridhara, Dodd, Laura, Gomber, Bhawna, Grothe, Monika, Herndon, Matthew, Herv�, Alain, Hussain, Usama, Klabbers, Pamela, Lanaro, Armando, Levine, Aaron, Long, Kenneth, Loveless, Richard, Ruggles, Tyler, Savin, Alexander, Smith, Nicholas, Smith, Wesley H., and Woods, Nathaniel

Subjects
p p: scattering, CERN Lab, lepton, 13000 GeV-cms, transverse momentum, 7. Clean energy, channel cross section: upper limit, boson: massive, Higgs particle: doublet, Higgs particle: hadroproduction, Z': mass: lower limit, benchmark, dark matter: associated production, Higgs particle: leptonic decay, tau: pair production, CMS, background, Z': model, dark matter: mass, boson: mediation, mass dependence, Higgs particle: radiative decay, channel cross section: branching ratio: upper limit, pseudoscalar particle: mass, dark matter: scattering, CERN LHC Coll, mass spectrum: (tau+ tau-), photon: pair production, p p: colliding beams, mass spectrum: two-photon, experimental results
Abstract

Journal of high energy physics 1809(9), 46 (2018). doi:10.1007/JHEP09(2018)046, Published by SISSA, [Trieste]

28. Search for dark matter produced in association with a Higgs boson decaying to $\gamma\gamma$ or $\tau^+\tau^-$ at $\sqrt{s} =$ 13 TeV

Author

Sirunyan, Albert M., Tumasyan, Armen, Adam, Wolfgang, Ambrogi, Federico, Asilar, Ece, Bergauer, Thomas, Brandstetter, Johannes, Dragicevic, Marko, Er�, Janos, Escalante Del Valle, Alberto, Flechl, Martin, Fruehwirth, Rudolf, Ghete, Vasile Mihai, Hrubec, Josef, Jeitler, Manfred, Krammer, Natascha, Kr�Tschmer, Ilse, Liko, Dietrich, Madlener, Thomas, Mikulec, Ivan, Rad, Navid, Rohringer, Herbert, Schieck, Jochen, Sch�Fbeck, Robert, Spanring, Markus, Spitzbart, Daniel, Taurok, Anton, Waltenberger, Wolfgang, Wittmann, Johannes, Wulz, Claudia-Elisabeth, Zarucki, Mateusz, Chekhovsky, Vladimir, Mossolov, Vladimir, Gonzalez, Juan Suarez, De Wolf, Eddi A., Di Croce, Davide, Janssen, Xavier, Lauwers, Jasper, Pieters, Maxim, Van De Klundert, Merijn, Van Haevermaet, Hans, Van Mechelen, Pierre, Van Remortel, Nick, Abu Zeid, Shimaa, Blekman, Freya, D'Hondt, Jorgen, De Bruyn, Isabelle, De Clercq, Jarne, Deroover, Kevin, Flouris, Giannis, Lontkovskyi, Denys, Lowette, Steven, Marchesini, Ivan, Moortgat, Seth, Moreels, Lieselotte, Python, Quentin, Skovpen, Kirill, Tavernier, Stefaan, Van Doninck, Walter, Van Mulders, Petra, Van Parijs, Isis, Beghin, Diego, Bilin, Bugra, Brun, Hugues, Clerbaux, Barbara, De Lentdecker, Gilles, Delannoy, Hugo, Dorney, Brian, Fasanella, Giuseppe, Favart, Laurent, Goldouzian, Reza, Grebenyuk, Anastasia, Kalsi, Amandeep Kaur, Lenzi, Thomas, Luetic, Jelena, Postiau, Nicolas, Starling, Elizabeth, Thomas, Laurent, Vander Velde, Catherine, Vanlaer, Pascal, Vannerom, David, Wang, Qun, Cornelis, Tom, Dobur, Didar, Fagot, Alexis, Gul, Muhammad, Khvastunov, Illia, Poyraz, Deniz, Roskas, Christos, Trocino, Daniele, Tytgat, Michael, Verbeke, Willem, Vermassen, Basile, Vit, Martina, Zaganidis, Nicolas, Bakhshiansohi, Hamed, Bondu, Olivier, Brochet, S�Bastien, Bruno, Giacomo, Caputo, Claudio, David, Pieter, Delaere, Christophe, Delcourt, Martin, Francois, Brieuc, Giammanco, Andrea, Krintiras, Georgios, Lemaitre, Vincent, Magitteri, Alessio, Mertens, Alexandre, Musich, Marco, Piotrzkowski, Krzysztof, Saggio, Alessia, Vidal Marono, Miguel, Wertz, S�Bastien, Zobec, Joze, Alves, F�Bio L�Cio, Alves, Gilvan, Brito, Lucas, Correa Martins Junior, Marcos, Correia Silva, Gilson, Hensel, Carsten, Moraes, Arthur, Pol, Maria Elena, Rebello Teles, Patricia, Belchior Batista Das Chagas, Ewerton, Carvalho, Wagner, Chinellato, Jose, Coelho, Eduardo, Melo Da Costa, Eliza, Da Silveira, Gustavo Gil, De Jesus Damiao, Dilson, De Oliveira Martins, Carley, Fonseca De Souza, Sandro, Malbouisson, Helena, Figueiredo, Diego Matos, Melo De Almeida, Miqueias, Mora Herrera, Clemencia, Mundim, Luiz, Nogima, Helio, Prado Da Silva, Wanda Lucia, Sanchez Rosas, Luis Junior, Santoro, Alberto, Sznajder, Andre, Thiel, Mauricio, Manganote, Edmilson Jos� Tonelli, Torres Da Silva De Araujo, Felipe, Vilela Pereira, Antonio, Ahuja, Sudha, Bernardes, Cesar Augusto, Calligaris, Luigi, Tomei, Thiago, De Moraes Gregores, Eduardo, Mercadante, Pedro G., Novaes, Sergio F., Padula, Sandra, Abad, David Romero, Aleksandrov, Aleksandar, Hadjiiska, Roumyana, Iaydjiev, Plamen, Marinov, Andrey, Misheva, Milena, Rodozov, Mircho, Shopova, Mariana, Sultanov, Georgi, Dimitrov, Anton, Litov, Leander, Pavlov, Borislav, Petkov, Peicho, Fang, Wenxing, Gao, Xuyang, Yuan, Li, Ahmad, Muhammad, Bian, Jian-Guo, Chen, Guo-Ming, Chen, He-Sheng, Chen, Mingshui, Chen, Ye, Jiang, Chun-Hua, Leggat, Duncan, Liao, Hongbo, Liu, Zhenan, Romeo, Francesco, Shaheen, Sarmad Masood, Spiezia, Aniello, Tao, Junquan, Wang, Chunjie, Wang, Zheng, Yazgan, Efe, Zhang, Huaqiao, Zhao, Jingzhou, Ban, Yong, Chen, Geng, Levin, Andrew, Li, Jing, Li, Linwei, Li, Qiang, Mao, Yajun, Qian, Si-Jin, Wang, Dayong, Xu, Zijun, Wang, Yi, Avila, Carlos, Cabrera, Andr�S, Carrillo Montoya, Camilo Andres, Chaparro Sierra, Luisa Fernanda, Florez, Carlos, Hern�Ndez, Carlos Felipe Gonz�Lez, Segura Delgado, Manuel Alejandro, Courbon, Benoit, Godinovic, Nikola, Lelas, Damir, Puljak, Ivica, Sculac, Toni, Antunovic, Zeljko, Kovac, Marko, Brigljevic, Vuko, Ferencek, Dinko, Kadija, Kreso, Mesic, Benjamin, Starodumov, Andrei, Susa, Tatjana, Ather, Mohsan Waseem, Attikis, Alexandros, Kolosova, Marina, Mavromanolakis, Georgios, Mousa, Jehad, Nicolaou, Charalambos, Ptochos, Fotios, Razis, Panos A., Rykaczewski, Hans, Finger, Miroslav, Finger, Michael, Ayala, Edy, Carrera Jarrin, Edgar, Assran, Yasser, Elgammal, Sherif, Khalil, Shaaban, Bhowmik, Sandeep, Carvalho Antunes De Oliveira, Alexandra, Dewanjee, Ram Krishna, Ehataht, Karl, Kadastik, Mario, Raidal, Martti, Veelken, Christian, Eerola, Paula, Kirschenmann, Henning, Pekkanen, Juska, Voutilainen, Mikko, Havukainen, Joona, Heikkil�, Jaana Kristiina, Jarvinen, Terhi, Karim�Ki, Veikko, Kinnunen, Ritva, Lamp�N, Tapio, Lassila-Perini, Kati, Laurila, Santeri, Lehti, Sami, Lind�N, Tomas, Luukka, Panja-Riina, M�Enp��, Teppo, Siikonen, Hannu, Tuominen, Eija, Tuominiemi, Jorma, Tuuva, Tuure, Besancon, Marc, Couderc, Fabrice, Dejardin, Marc, Denegri, Daniel, Faure, Jean-Louis, Ferri, Federico, Ganjour, Serguei, Givernaud, Alain, Gras, Philippe, Hamel De Monchenault, Gautier, Jarry, Patrick, Leloup, Cl�Ment, Locci, Elizabeth, Malcles, Julie, Negro, Giulia, Rander, John, Rosowsky, Andr�, Sahin, Mehmet �Zg�R, Titov, Maksym, Abdulsalam, Abdulla, Amendola, Chiara, Antropov, Iurii, Beaudette, Florian, Busson, Philippe, Charlot, Claude, Granier De Cassagnac, Raphael, Kucher, Inna, Lisniak, Stanislav, Lobanov, Artur, Martin Blanco, Javier, Nguyen, Matthew, Ochando, Christophe, Ortona, Giacomo, Pigard, Philipp, Salerno, Roberto, Sauvan, Jean-Baptiste, Sirois, Yves, Stahl Leiton, Andre Govinda, Zabi, Alexandre, Zghiche, Amina, Agram, Jean-Laurent, Andrea, Jeremy, Bloch, Daniel, Brom, Jean-Marie, Chabert, Eric Christian, Cherepanov, Vladimir, Collard, Caroline, Conte, Eric, Fontaine, Jean-Charles, Gel�, Denis, Goerlach, Ulrich, Jansov�, Mark�Ta, Le Bihan, Anne-Catherine, Tonon, Nicolas, Van Hove, Pierre, Gadrat, S�Bastien, Beauceron, Stephanie, Bernet, Colin, Boudoul, Gaelle, Chanon, Nicolas, Chierici, Roberto, Contardo, Didier, Depasse, Pierre, El Mamouni, Houmani, Fay, Jean, Finco, Linda, Gascon, Susan, Gouzevitch, Maxime, Grenier, G�Rald, Ille, Bernard, Lagarde, Francois, Laktineh, Imad Baptiste, Lattaud, Hugues, Lethuillier, Morgan, Mirabito, Laurent, Pequegnot, Anne-Laure, Perries, Stephane, Popov, Andrey, Sordini, Viola, Vander Donckt, Muriel, Viret, S�Bastien, Zhang, Sijing, Khvedelidze, Arsen, Tsamalaidze, Zviad, Autermann, Christian, Feld, Lutz, Kiesel, Maximilian Knut, Klein, Katja, Lipinski, Martin, Preuten, Marius, Rauch, Max Philip, Schomakers, Christian, Schulz, Johannes, Teroerde, Marius, Wittmer, Bruno, Zhukov, Valery, Albert, Andreas, Duchardt, Deborah, Endres, Matthias, Erdmann, Martin, Esch, Thomas, Fischer, Robert, Ghosh, Saranya, G�Th, Andreas, Hebbeker, Thomas, Heidemann, Carsten, Hoepfner, Kerstin, Keller, Henning, Knutzen, Simon, Mastrolorenzo, Luca, Merschmeyer, Markus, Meyer, Arnd, Millet, Philipp, Mukherjee, Swagata, Pook, Tobias, Radziej, Markus, Reithler, Hans, Rieger, Marcel, Scheuch, Florian, Schmidt, Alexander, Teyssier, Daniel, Fl�Gge, G�Nter, Hlushchenko, Olena, Kargoll, Bastian, Kress, Thomas, K�Nsken, Andreas, M�Ller, Thomas, Nehrkorn, Alexander, Nowack, Andreas, Pistone, Claudia, Pooth, Oliver, Sert, Hale, Stahl, Achim, Aldaya Martin, Maria, Arndt, Till, Asawatangtrakuldee, Chayanit, Babounikau, Illia, Beernaert, Kelly, Behnke, Olaf, Behrens, Ulf, Mart�Nez, Armando Berm�Dez, Bertsche, David, Bin Anuar, Afiq Aizuddin, Borras, Kerstin, Botta, Valeria, Campbell, Alan, Connor, Patrick, Contreras-Campana, Christian, Costanza, Francesco, Danilov, Vladyslav, De Wit, Adinda, Defranchis, Matteo Maria, Diez Pardos, Carmen, Damiani, Daniela Dom�Nguez, Eckerlin, Guenter, Eichhorn, Thomas, Elwood, Adam, Eren, Engin, Gallo, Elisabetta, Geiser, Achim, Grados Luyando, Juan Manuel, Grohsjean, Alexander, Gunnellini, Paolo, Guthoff, Moritz, Haranko, Mykyta, Harb, Ali, Hauk, Johannes, Jung, Hannes, Kasemann, Matthias, Keaveney, James, Kleinwort, Claus, Knolle, Joscha, Kr�Cker, Dirk, Lange, Wolfgang, Lelek, Aleksandra, Lenz, Teresa, Lipka, Katerina, Lohmann, Wolfgang, Mankel, Rainer, Melzer-Pellmann, Isabell-Alissandra, Meyer, Andreas Bernhard, Meyer, Mareike, Missiroli, Marino, Mittag, Gregor, Mnich, Joachim, Myronenko, Volodymyr, Pflitsch, Svenja Karen, Pitzl, Daniel, Raspereza, Alexei, Savitskyi, Mykola, Saxena, Pooja, Sch�Tze, Paul, Schwanenberger, Christian, Shevchenko, Rostyslav, Singh, Akshansh, Stefaniuk, Nazar, Tholen, Heiner, Turkot, Oleksii, Vagnerini, Antonio, Van Onsem, Gerrit Patrick, Walsh, Roberval, Wen, Yiwen, Wichmann, Katarzyna, Wissing, Christoph, Zenaiev, Oleksandr, Aggleton, Robin, Bein, Samuel, Benato, Lisa, Benecke, Anna, Blobel, Volker, Centis Vignali, Matteo, Dreyer, Torben, Garutti, Erika, Gonzalez, Daniel, Haller, Johannes, Hinzmann, Andreas, Karavdina, Anastasia, Kasieczka, Gregor, Klanner, Robert, Kogler, Roman, Kovalchuk, Nataliia, Kurz, Simon, Kutzner, Viktor, Lange, Johannes, Marconi, Daniele, Multhaup, Jens, Niedziela, Marek, Nowatschin, Dominik, Perieanu, Adrian, Reimers, Arne, Rieger, Oliver, Scharf, Christian, Schleper, Peter, Schumann, Svenja, Schwandt, Joern, Sonneveld, Jory, Stadie, Hartmut, Steinbr�Ck, Georg, Stober, Fred-Markus Helmut, St�Ver, Marc, Troendle, Daniel, Vanhoefer, Annika, Vormwald, Benedikt, Akbiyik, Melike, Barth, Christian, Baselga, Marta, Baur, Sebastian, Butz, Erik, Caspart, Ren�, Chwalek, Thorsten, Colombo, Fabio, De Boer, Wim, Dierlamm, Alexander, Faltermann, Nils, Freund, Benedikt, Giffels, Manuel, Harrendorf, Marco Alexander, Hartmann, Frank, Heindl, Stefan Michael, Husemann, Ulrich, Kassel, Florian, Katkov, Igor, Kudella, Simon, Mildner, Hannes, Mitra, Soureek, Mozer, Matthias Ulrich, Plagge, Michael, Quast, Gunter, Rabbertz, Klaus, Schr�Der, Matthias, Shvetsov, Ivan, Sieber, Georg, Simonis, Hans-J�Rgen, Ulrich, Ralf, Wayand, Stefan, Weber, Marc, Weiler, Thomas, Williamson, Shawn, W�Hrmann, Clemens, 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Navarria, Francesco, Perrotta, Andrea, Primavera, Federica, Rossi, Antonio, Rovelli, Tiziano, Siroli, Gian Piero, Tosi, Nicol�, Albergo, Sebastiano, Di Mattia, Alessandro, Potenza, Renato, Tricomi, Alessia, Tuve, Cristina, Barbagli, Giuseppe, Chatterjee, Kalyanmoy, Ciulli, Vitaliano, Civinini, Carlo, D'Alessandro, Raffaello, Focardi, Ettore, Latino, Giuseppe, Lenzi, Piergiulio, Meschini, Marco, Paoletti, Simone, Russo, Lorenzo, Sguazzoni, Giacomo, Strom, Derek, Viliani, Lorenzo, Benussi, Luigi, Bianco, Stefano, Fabbri, Franco, Piccolo, Davide, Ferro, Fabrizio, Ravera, Fabio, Robutti, Enrico, Tosi, Silvano, Benaglia, Andrea, Beschi, Andrea, Brianza, Luca, Brivio, Francesco, Ciriolo, Vincenzo, Di Guida, Salvatore, Dinardo, Mauro Emanuele, Fiorendi, Sara, Gennai, Simone, Ghezzi, Alessio, Govoni, Pietro, Malberti, Martina, Malvezzi, Sandra, Massironi, Andrea, Menasce, Dario, Moroni, Luigi, Paganoni, Marco, Pedrini, Daniele, Ragazzi, Stefano, Tabarelli De Fatis, Tommaso, Buontempo, Salvatore, Cavallo, Nicola, Di Crescenzo, Antonia, Fabozzi, Francesco, Fienga, Francesco, Galati, Giuliana, Iorio, Alberto Orso Maria, Khan, Wajid Ali, Lista, Luca, Meola, Sabino, Paolucci, Pierluigi, Sciacca, Crisostomo, Voevodina, Elena, Azzi, Patrizia, Bacchetta, Nicola, Bisello, Dario, Boletti, Alessio, Bragagnolo, Alberto, Carlin, Roberto, Checchia, Paolo, Dall'Osso, Martino, De Castro Manzano, Pablo, Dorigo, Tommaso, Dosselli, Umberto, Gasparini, Fabrizio, Gasparini, Ugo, Gozzelino, Andrea, Lacaprara, Stefano, Lujan, Paul, Margoni, Martino, Meneguzzo, Anna Teresa, Pazzini, Jacopo, Ronchese, Paolo, Rossin, Roberto, Simonetto, Franco, Tiko, Andres, Torassa, Ezio, Zanetti, Marco, Zotto, Pierluigi, Zumerle, Gianni, Braghieri, Alessandro, Magnani, Alice, Montagna, Paolo, Ratti, Sergio P., Re, Valerio, Ressegotti, Martina, Riccardi, Cristina, Salvini, Paola, Vai, Ilaria, Vitulo, Paolo, Alunni Solestizi, Luisa, Biasini, Maurizio, Bilei, Gian Mario, Cecchi, Claudia, Ciangottini, Diego, 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Arcidiacono, Roberta, Argiro, Stefano, Arneodo, Michele, Bartosik, Nazar, Bellan, Riccardo, Biino, Cristina, Cartiglia, Nicolo, Cenna, Francesca, Cometti, Simona, Costa, Marco, Covarelli, Roberto, Demaria, Natale, Kiani, Bilal, Mariotti, Chiara, Maselli, Silvia, Migliore, Ernesto, Monaco, Vincenzo, Monteil, Ennio, Monteno, Marco, Obertino, Maria Margherita, Pacher, Luca, Pastrone, Nadia, Pelliccioni, Mario, Pinna Angioni, Gian Luca, Romero, Alessandra, Ruspa, Marta, Sacchi, Roberto, Shchelina, Ksenia, Sola, Valentina, Solano, Ada, Soldi, Dario, Staiano, Amedeo, Belforte, Stefano, Candelise, Vieri, Casarsa, Massimo, Cossutti, Fabio, Della Ricca, Giuseppe, Vazzoler, Federico, Zanetti, Anna, Kim, Dong Hee, Kim, Gui Nyun, Kim, Min Suk, Lee, Jeongeun, Lee, Sangeun, Lee, Seh Wook, Moon, Chang-Seong, Oh, Young Do, Sekmen, Sezen, Son, Dong-Chul, Yang, Yu Chul, Kim, Hyunchul, Moon, Dong Ho, Oh, Geonhee, Goh, Junghwan, Kim, Tae Jeong, Cho, Sungwoong, Choi, Suyong, Go, Yeonju, Gyun, Dooyeon, Ha, 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Subjects
p p: scattering, CERN Lab, lepton, 13000 GeV-cms, transverse momentum, 7. Clean energy, channel cross section: upper limit, boson: massive, Higgs particle: doublet, Higgs particle: hadroproduction, Z': mass: lower limit, benchmark, dark matter: associated production, Higgs particle: leptonic decay, tau: pair production, CMS, background, dark matter: mass, Z': model, boson: mediation, mass dependence, pseudoscalar particle: mass, Higgs particle: radiative decay, channel cross section: branching ratio: upper limit, dark matter: scattering, CERN LHC Coll, mass spectrum: (tau+ tau-), photon: pair production, p p: colliding beams, mass spectrum: two-photon, experimental results
Abstract

Journal of high energy physics 1809(09), 046 (2018). doi:10.1007/JHEP09(2018)046, A search for dark matter particles is performed by looking for events with large transverse momentum imbalance and a recoiling Higgs boson decaying to either a pair of photons or a pair of τ leptons. The search is based on proton-proton collision data at a center-of-mass energy of 13 TeV collected at the CERN LHC in 2016 and corresponding to an integrated luminosity of 35.9 fb$^{−1}$. No significant excess over the expected standard model background is observed. Upper limits at 95% confidence level are presented for the product of the production cross section and branching fraction in the context of two benchmark simplified models. For the Z$^{′}$-two-Higgs-doublet model (where Z$^{′}$ is a new massive boson mediator) with an intermediate heavy pseudoscalar particle of mass m$_{A}$ = 300 GeV and m$_{DM}$ = 100 GeV, the Z$^{′}$ masses from 550 GeV to 1265 GeV are excluded. For a baryonic Z$^{′}$ model, with m$_{DM}$ = 1 GeV, Z$^{′}$ masses up to 615 GeV are excluded. Results are also presented for the spin-independent cross section for the dark matter-nucleon interaction as a function of the mass of the dark matter particle. This is the first search for dark matter particles produced in association with a Higgs boson decaying to two τ leptons., Published by Springer Nature, Cham

29. Escherichia coli-Specific CXCL13-Producing TFH Are Associated with Clinical Efficacy of Neoadjuvant PD-1 Blockade against Muscle-Invasive Bladder Cancer

Author

Anne-Gaëlle Goubet, Leonardo Lordello, Carolina Alves Costa Silva, Isabelle Peguillet, Marianne Gazzano, Maxime Descartes Mbogning-Fonkou, Cassandra Thelemaque, Cédric Lebacle, Constance Thibault, François Audenet, Géraldine Pignot, Gwenaelle Gravis, Carole Helissey, Luca Campedel, Morgan Roupret, Evanguelos Xylinas, Idir Ouzaid, Agathe Dubuisson, Marine Mazzenga, Caroline Flament, Pierre Ly, Virginie Marty, Nicolas Signolle, Allan Sauvat, Thomas Sbarrato, Mounia Filahi, Caroline Davin, Gabriel Haddad, Jacques Bou Khalil, Camille Bleriot, François-Xavier Danlos, Garett Dunsmore, Kevin Mulder, Aymeric Silvin, Thibault Raoult, Baptiste Archambaud, Shaima Belhechmi, Ivo Gomperts Boneca, Nadège Cayet, Maryse Moya-Nilges, Adeline Mallet, Romain Daillere, Etienne Rouleau, Camelia Radulescu, Yves Allory, Jacques Fieschi, Mathieu Rouanne, Florent Ginhoux, Gwénaël Le Teuff, Lisa Derosa, Aurélien Marabelle, Jeroen Van Dorp, Nick Van Dijk, Michiel S. Van Der Heijden, Benjamin Besse, Fabrice Andre, Miriam Merad, Guido Kroemer, Jean-Yves Scoazec, Laurence Zitvogel, Yohann Loriot, Université Paris-Saclay, Institut Gustave Roussy (IGR), Immunologie anti-tumorale et immunothérapie des cancers (ITIC), Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, NF-kappaB, Différenciation et Cancer (OncokappaB (URP_7324)), Université Paris Cité (UPCité), Immunologie intégrative des tumeurs et immunothérapie des cancers (INTIM), Institut Curie [Paris], Centre d'Immunologie et des Maladies Infectieuses (CIMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Petites Molécules de neuroprotection, neurorégénération et remyélinisation, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital d'Instruction des Armées Begin, Service de Santé des Armées, CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Immunologie des tumeurs et immunothérapie (UMR 1015), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Département d’Innovation Thérapeutique et essais précoces [Gustave Roussy] (DITEP), Direction de la recherche clinique [Gustave Roussy], Service de biostatistique et d'épidémiologie (SBE), Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Département de médecine oncologique [Gustave Roussy], Département de biologie et pathologie médicales [Gustave Roussy], Oncologie gynécologique, ANR-16-RHUS-0008, ANR-21-RHUS-0017, Bristol-Myers Squibb, BMS, Pfizer, Astellas Pharma US, APUS, AstraZeneca, Genentech, Merck, Roche, Gilead Sciences, Meso Scale Diagnostics, MSD, Janssen Pharmaceuticals, Merck Sharp and Dohme, MSD, Horizon 2020 Framework Programme, H2020: 19-CE15-0029-01, 825410, Clovis Oncology, Seerave Foundation, Fondation Philanthropia, Advanced Accelerator Applications, AAA, Agence Nationale de la Recherche, ANR: ANR-10-LABX-62-IBEID, Fondation pour la Recherche Médicale, FRM, Daiichi-Sankyo, Fondation ARC pour la Recherche sur le Cancer, ARC, Ligue Contre le Cancer, Institut Universitaire de France, IUF, Institut National Du Cancer, INCa, Cancéropôle Ile de France, Association Française d'Urologie, AFU, Labex Immuno-Oncology, The trial was conducted by the French Genitourinary Group (GETUG) and funded by MSD, which provided the drug. This study was approved by the ethics committee CPP Est-III in December 2017 and the French National Agency for the Safety of Medicines and Health Products (ANSM) in November 2017, and was conducted in accordance with the protocols and Good Clinical Practice Guidelines defined by the International Conference for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use and the principles of the Declaration of Helsinki., C. Alves Costa Silva reports grants from MSD Avenir Foundation during the conduct of the study. C. Thibault reports personal fees and nonfinancial support from Pfizer, Merck, MSD, Janssen, and Ipsen, grants, personal fees, and nonfinancial support from AstraZeneca, We thank pathologists, nurses, and clinical research associates from Hôpital Européenn George Pompidou, Hôpital Begin, Institut Paoli-Calmettes, Hôpital Bichat, and Hôpital Pitié-Salpétrière for their participation in the PANDORE clinical trial. We are thankful to the flow and mass cytometry facility team of Gustave Roussy (Philippe Rameau and Cyril Catelain). We thank Fluidigm for their support. We are grateful for support for equipment from the French Government Programme Investissements d’Avenir France BioImag-ing (FBI, No. ANR-10-INSB-04-01) and the French Government (Agence Nationale de la Recherche) Investissement d’Avenir program, Laboratoire d’Excellence 'Integrative Biology of Emerging Infectious Diseases' (ANR-10-LABX-62-IBEID). A.-G. Goubet was supported by Fondation pour la Recherche Médicale. C. Alves Costa Silva was supported by MSD Avenir. F.-X. Danlos was supported by Fondation Philantropia. M. Roupret was supported by Fondation Foch and the Association Française d’Urologie (AFU). L. Zitvogel was funded by the RHU Torino Lumière (ANR-16-RHUS-0008). L. Zitvogel and L. Derosa were supported by RHU5 'ANR-21-RHUS-0017' IMMUNOLIFE, SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE), as well as the SIGN’IT ARC foundation. L. Zitvogel was supported by European Union’s Horizon 2020 research and innovation programme under grant agreement number 825410 [project acronym: ONCOBIOME, project title: Gut OncoMicrobiome Signatures (GOMS) associated with cancer incidence, prognosis, and prediction of treatment response]. L. Zitvogel also received an ANR grant–French-German Ileobiome 19-CE15-0029-01. L. Zitvogel and G. Kroemer received a donation from the Seerave Foundation. L. Zitvogel and G. Kroemer were supported by the Ligue contre le Cancer (équipe labelisée), ANR projets blancs, Cancéropôle Ile-de-France, Fondation pour la Recherche Médicale (FRM), a donation by Elior, Institut National du Cancer (INCa), Inserm (HTE), Institut Universitaire de France, the LabEx Immuno-Oncology, and FHU CARE, Dassault, and Badinter Philantropia. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact., Bristol Myers Squibb, and Sanofi, and personal fees from Astellas and AAA during the conduct of the study, as well as personal fees and nonfinancial support from Pfizer, Merck, MSD, Janssen, and Ipsen, grants, personal fees, and nonfinancial support from AstraZeneca, Bristol Myers Squibb, and Sanofi, and personal fees from Astellas and AAA outside the submitted work. F. Audenet reports personal fees from Astellas, Urodiag, Vitadx, and Bristol Myers Squibb, and nonfinancial support from Ipsen outside the submitted work. G. Gravis reports grants from Bristol Myers Squibb, and other support from MSD, Bristol Myers Squibb, and Merck–Pfizer alliance outside the submitted work. C. Helissey reports personal fees from Janssen-Cilag, Roche, Bayer, AstraZeneca, and Astellas outside the submitted work. L. Cam-pedel reports personal fees from MSD, Pfizer, Bristol Myers Squibb, and Bayer outside the submitted work. T. Sbarrato reports personal fees from Veracyte during the conduct of the study. T. Raoult reports grants, personal fees, and nonfinancial support from Merck Sharp & Dohme during the conduct of the study. E. Rouleau reports grants from AstraZeneca, Roche, Clovis, Bristol Myers Squibb, and MSD outside the submitted work. Y. Allory reports other support from Astra-Zeneca, MSD, and Bristol Myers Squibb outside the submitted work. J. Fieschi reports personal fees from Veracyte during the conduct of the study. A. Marabelle reports grants, personal fees, nonfinancial support, and other support from MSD, Bristol Myers Squibb, and AstraZeneca, and personal fees, nonfinancial support, and other support from Roche/Genentech and Pfizer outside the submitted work. J. Van Dorp reports other support from Bristol Myers Squibb during the conduct of the study. M.S. van der Heijden reports grants from Bristol Myers Squibb during the conduct of the study, as well as grants and personal fees from Bristol Myers Squibb, Roche, and AstraZeneca, grants from 4SC, and personal fees from MSD/Merck, Janssen, Pfizer, and Seagen outside the submitted work. B. Besse reports grants from 4D Pharma, AbbVie, Amgen, Aptitude Health, AstraZeneca, BeiGene, Blueprint Medicines, Boehringer Ingelheim, Celgene, Cergentis, Chu-gai Pharmaceutical, Cristal Therapeutics, Daiichi Sankyo, Eli Lilly, Eisai, Genzyme Corporation, GSK, Inivata, Ipsen, Janssen, Onxeo, OSE Immunotherapeutics, Pfizer, Roche/Genentech, Sanofi, Takeda, Tolero Pharmaceuticals, and Turning Point Therapeutics during the conduct of the study. F. Andre reports grants and other support from AstraZeneca and Daiichi Sankyo, grants from Lilly and Sanofi, and other support from Novartis and Relay outside the submitted work. M. Merad reports grants and personal fees from Regeneron, personal fees from Compugen, Morphic Therapeutics, Myeloid Therapeutics, Nirogy, DrenBio, Oncoresponse, Asherbio, Pionyr, Owkin, and Larkspur, other support from Innate Pharma, Genenta, DBV, and OSE Immunotherapeutics, and grants from Boehringer outside the submitted work. G. Kroemer reports grants from Daiichi Sankyo, Eleor, Kaleido, Lytix Pharma, PharmaMar, Osasuna Therapeutics, Samsara Therapeutics, Sanofi, Sotio, Tollys, Vascage, and Vasculox/Tioma, and personal fees from Reithera outside the submitted work, is on the Board of Directors for Bristol Myers Squibb Foundation France, and is a scientific cofounder of EverImmune, Osasuna Therapeutics, Samsara Therapeutics, and Therafast Bio. L. Zitvogel reports grants and personal fees from EverImmune, and grants from 9 Meters and Pileje during the conduct of the study, grants from Daiichi Sankyo outside the submitted work, and a patent for B220028EPA pending. Y. Loriot reports grants from MSD and personal fees from MSD during the conduct of the study, personal fees from Bristol Myers Squibb, Pfizer, Merck Serono, AstraZeneca, Seattle Genetics, Gilead, Taiho, and Astel-las, grants and personal fees from Janssen, and grants from Roche and Celsius outside the submitted work, and a patent for EP2305181.4 pending. No disclosures were reported by the other authors., and FHU CARE, Dassault, and Badinter Philantropia., ANR-16-RHUS-0008,LUMIERE,LUMIERE(2016), and ANR-21-RHUS-0017,IMMUNOLIFE,Microbiota-centered interventions to solve antibiotics-induced primary resistance to immune checkpoint inhibitors(2021)

Subjects
[SDV]Life Sciences [q-bio], Muscles, Programmed Cell Death 1 Receptor, T-Lymphocytes, Helper-Inducer, Chemokine CXCL13, B7-H1 Antigen, Neoadjuvant Therapy, Treatment Outcome, Oncology, Urinary Bladder Neoplasms, Immunoglobulin G, Escherichia coli, Humans, Immune Checkpoint Inhibitors
Abstract

Biomarkers guiding the neoadjuvant use of immune-checkpoint blockers (ICB) are needed for patients with localized muscle-invasive bladder cancers (MIBC). Profiling tumor and blood samples, we found that follicular helper CD4+ T cells (TFH) are among the best therapeutic targets of pembrolizumab correlating with progression-free survival. TFH were associated with tumoral CD8 and PD-L1 expression at baseline and the induction of tertiary lymphoid structures after pembrolizumab. Blood central memory TFH accumulated in tumors where they produce CXCL13, a chemokine found in the plasma of responders only. IgG4+CD38+ TFH residing in bladder tissues correlated with clinical benefit. Finally, TFH and IgG directed against urothelium-invasive Escherichia coli dictated clinical responses to pembrolizumab in three independent cohorts. The links between tumor infection and success of ICB immunomodulation should be prospectively assessed at a larger scale. Significance: In patients with bladder cancer treated with neoadjuvant pembrolizumab, E. coli–specific CXCL13 producing TFH and IgG constitute biomarkers that predict clinical benefit. Beyond its role as a biomarker, such immune responses against E. coli might be harnessed for future therapeutic strategies. This article is highlighted in the In This Issue feature, p. 2221

Published
2022

30. Impact of model-informed precision dosing on achievement of vancomycin exposure targets in pediatric patients with cystic fibrosis.

Author

Frymoyer A, Schwenk HT, Brockmeyer JM, and Bio L

Subjects
Humans, Child, Vancomycin, Anti-Bacterial Agents, Retrospective Studies, Bayes Theorem, Area Under Curve, Microbial Sensitivity Tests, Cystic Fibrosis drug therapy, Methicillin-Resistant Staphylococcus aureus, Acute Kidney Injury chemically induced
Abstract

Background: Vancomycin is commonly used to treat acute pulmonary exacerbations in pediatric patients with cystic fibrosis (CF) and a history of methicillin-resistant Staphylococcus aureus. Optimizing vancomycin exposure during therapy is essential and area under-the-curve (AUC)-guided dosing is now recommended. Model-informed precision dosing (MIPD) utilizing Bayesian forecasting is a powerful approach that can support AUC-guided dose individualization. The objective of the current study was to examine the impact of implementing an AUC-guided dose individualization approach supported via a MIPD clinical decision support (CDS) tool on vancomycin exposure, target attainment rate, and safety in pediatric patients with CF treated with vancomycin during clinical care., Methods: A retrospective chart review was performed in patients with CF at a single children's hospital comparing pre- and post-implementation of a MIPD approach for vancomycin supported by a cloud-based, CDS tool integrated into the electronic health record (EHR). In the pre-MIPD period, vancomycin starting doses of 60 mg/kg/day (<13 years) or 45 mg/kg/day (≥13 years) were used. Dose adjustment was guided by therapeutic drug monitoring (TDM) with a target trough 10-20 mg/L. In the post-MIPD period, starting dose and dose adjustment were based on the MIPD CDS tool predictions with a target 24 h AUC (AUC 24 ) 400-600 mg*h/L. Exposure and target achievement rates were retrospectively calculated and compared. Rates of acute kidney injury (AKI) were also compared., Results: Overall, 23 patient courses were included in the pre-MIPD period and 21 patient courses in the post-MIPD period. In the post-MIPD period, an individualized MIPD starting dose resulted in 71% of patients achieving target AUC 24 compared to 39% in the pre-MIPD period (p < 0.05). After the first TDM and dose adjustment, target AUC 24 achievement was also higher post-MIPD versus pre-MIPD (86% vs. 57%; p < 0.05). AKI rates were low and similar between periods (pre-MIPD 8.7% vs. post-MIPD 9.5%; p = 0.9)., Conclusion: An MIPD approach implemented within a cloud-based, EHR-integrated CDS tool safely supported vancomycin AUC-guided dosing and resulted in high rates of target achievement., (© 2023 Pharmacotherapy Publications, Inc.)

Published
2023
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31. Multicenter Interim Guidance on Use of Antivirals for Children With Coronavirus Disease 2019/Severe Acute Respiratory Syndrome Coronavirus 2.

Author

Chiotos K, Hayes M, Kimberlin DW, Jones SB, James SH, Pinninti SG, Yarbrough A, Abzug MJ, MacBrayne CE, Soma VL, Dulek DE, Vora SB, Waghmare A, Wolf J, Olivero R, Grapentine S, Wattier RL, Bio L, Cross SJ, Dillman NO, Downes KJ, Oliveira CR, Timberlake K, Young J, Orscheln RC, Tamma PD, Schwenk HT, Zachariah P, Aldrich ML, Goldman DL, Groves HE, Rajapakse NS, Lamb GS, Tribble AC, Hersh AL, Thorell EA, Denison MR, Ratner AJ, Newland JG, and Nakamura MM

Subjects
Adenosine Monophosphate analogs & derivatives, Adenosine Monophosphate therapeutic use, Alanine analogs & derivatives, Alanine therapeutic use, COVID-19 therapy, Child, Evidence-Based Medicine, Humans, Immunocompromised Host, Risk Factors, Severity of Illness Index, Systemic Inflammatory Response Syndrome drug therapy, Antiviral Agents therapeutic use, COVID-19 Drug Treatment
Abstract

Background: Although coronavirus disease 2019 (COVID-19) is a mild infection in most children, a small proportion develop severe or critical illness. Data describing agents with potential antiviral activity continue to expand such that updated guidance is needed regarding use of these agents in children., Methods: A panel of pediatric infectious diseases physicians and pharmacists from 20 geographically diverse North American institutions was convened. Through a series of teleconferences and web-based surveys, a set of guidance statements was developed and refined based on review of the best available evidence and expert opinion., Results: Given the typically mild course of COVID-19 in children, supportive care alone is suggested for most cases. For children with severe illness, defined as a supplemental oxygen requirement without need for noninvasive or invasive mechanical ventilation or extracorporeal membrane oxygenation (ECMO), remdesivir is suggested, preferably as part of a clinical trial if available. Remdesivir should also be considered for critically ill children requiring invasive or noninvasive mechanical ventilation or ECMO. A duration of 5 days is appropriate for most patients. The panel recommends against the use of hydroxychloroquine or lopinavir-ritonavir (or other protease inhibitors) for COVID-19 in children., Conclusions: Antiviral therapy for COVID-19 is not necessary for the great majority of pediatric patients. For children with severe or critical disease, this guidance offers an approach for decision-making regarding use of remdesivir., (© The Author(s) 2020. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Published
2021
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32. Multicenter Initial Guidance on Use of Antivirals for Children With Coronavirus Disease 2019/Severe Acute Respiratory Syndrome Coronavirus 2.

Author

Chiotos K, Hayes M, Kimberlin DW, Jones SB, James SH, Pinninti SG, Yarbrough A, Abzug MJ, MacBrayne CE, Soma VL, Dulek DE, Vora SB, Waghmare A, Wolf J, Olivero R, Grapentine S, Wattier RL, Bio L, Cross SJ, Dillman NO, Downes KJ, Timberlake K, Young J, Orscheln RC, Tamma PD, Schwenk HT, Zachariah P, Aldrich M, Goldman DL, Groves HE, Lamb GS, Tribble AC, Hersh AL, Thorell EA, Denison MR, Ratner AJ, Newland JG, and Nakamura MM

Subjects
Child, Humans, Risk Assessment, Severity of Illness Index, Antiviral Agents therapeutic use, COVID-19 Drug Treatment
Abstract

Background: Although coronavirus disease 2019 (COVID-19) is mild in nearly all children, a small proportion of pediatric patients develop severe or critical illness. Guidance is therefore needed regarding use of agents with potential activity against severe acute respiratory syndrome coronavirus 2 in pediatrics., Methods: A panel of pediatric infectious diseases physicians and pharmacists from 18 geographically diverse North American institutions was convened. Through a series of teleconferences and web-based surveys, a set of guidance statements was developed and refined based on review of best available evidence and expert opinion., Results: Given the typically mild course of pediatric COVID-19, supportive care alone is suggested for the overwhelming majority of cases. The panel suggests a decision-making framework for antiviral therapy that weighs risks and benefits based on disease severity as indicated by respiratory support needs, with consideration on a case-by-case basis of potential pediatric risk factors for disease progression. If an antiviral is used, the panel suggests remdesivir as the preferred agent. Hydroxychloroquine could be considered for patients who are not candidates for remdesivir or when remdesivir is not available. Antivirals should preferably be used as part of a clinical trial if available., Conclusions: Antiviral therapy for COVID-19 is not necessary for the great majority of pediatric patients. For those rare cases of severe or critical disease, this guidance offers an approach for decision-making regarding antivirals, informed by available data. As evidence continues to evolve rapidly, the need for updates to the guidance is anticipated., (© The Author(s) 2020. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Published
2020
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33. Model-Informed Precision Dosing of Vancomycin in Hospitalized Children: Implementation and Adoption at an Academic Children's Hospital.

Author

Frymoyer A, Schwenk HT, Zorn Y, Bio L, Moss JD, Chasmawala B, Faulkenberry J, Goswami S, Keizer RJ, and Ghaskari S

Abstract

Background: Model-informed precision dosing (MIPD) can serve as a powerful tool during therapeutic drug monitoring (TDM) to help individualize dosing in populations with large pharmacokinetic variation. Yet, adoption of MIPD in the clinical setting has been limited. Overcoming technologic hurdles that allow access to MIPD at the point-of-care and placing it in the hands of clinical specialists focused on medication dosing may encourage adoption., Objective: To describe the hospital implementation and usage of a MIPD clinical decision support (CDS) tool for vancomycin in a pediatric population., Methods: Within an academic children's hospital, MIPD for vancomycin was implemented via a commercial cloud-based CDS tool that utilized Bayesian forecasting. Clinical pharmacists were recognized as local champions to facilitate adoption of the tool and operated as end-users. Integration within the electronic health record (EHR) and automatic transmission of patient data to the tool were identified as important requirements. A web-link icon was developed within the EHR which when clicked sends users and needed patient-level clinical data to the CDS platform. Individualized pharmacokinetic predictions and exposure metrics for vancomycin are then presented in the form of a web-based dashboard. Use of the CDS tool as part of TDM was tracked and users were surveyed on their experience., Results: After a successful pilot phase in the neonatal intensive care unit, implementation of MIPD was expanded to the pediatric intensive care unit, followed by availability to the entire hospital. During the first 2+ years since implementation, a total of 853 patient-courses (n = 96 neonates, n = 757 children) and 2,148 TDM levels were evaluated using the CDS tool. For the most recent 6 months, the CDS tool was utilized to support 79% (181/230) of patient-courses in which TDM was performed. Of 26 users surveyed, > 96% agreed or strongly agreed that automatic transmission of patient data to the tool was a feature that helped them complete tasks more efficiently; 81% agreed or strongly agreed that they were satisfied with the CDS tool., Conclusions: Integration of a vancomycin CDS tool within the EHR, along with leveraging the expertise of clinical pharmacists, allowed for successful adoption of MIPD in clinical care., (Copyright © 2020 Frymoyer, Schwenk, Zorn, Bio, Moss, Chasmawala, Faulkenberry, Goswami, Keizer and Ghaskari.)

Published
2020
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