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Octreotide is a octapeptide that mimics natural somatostatin pharmacologically. It exerts Inhibitory effects on gastrointestinal secretion and motility thus considered, useful in management of gastrointestinal stula. The half life of octerotide is 113 minutes which allow intermittent (three times daily) subcutaneous dosing schedule for the treatment of stula. The main focus of this review is to know the use of octreotide in management of enterocutaneous stula.