1. Protective role of Bacillus Calmette–Guérin vaccine in Alzheimer's disease progression: A systematic review and meta-analysis
- Author
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Tungki Pratama Umar, Nityanand Jain, Bella Stevanny, Binish Javed, Andyra Priandhana, Reynold Siburian, and Andrejs Kostiks
- Subjects
BCG vaccine ,Alzheimer's disease ,Prevention ,Dementia ,Bladder cancer ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Introduction: Alzheimer's disease (AD) represents a significant societal challenge, highlighting the need to explore effective prevention and treatment approaches. Recent literature has suggested that Bacillus Calmette-Guérin (BCG) vaccine may be a viable therapeutic option for immune disorders associated with AD due to its immunomodulatory properties and protection against various diseases. Methods: This systematic review aimed to evaluate the association of BCG vaccine in the prevention of AD using six medical-scientific databases. A meta-analytical approach was undertaken to estimate the risk of AD incidence in patients with and without BCG vaccine exposure, followed by subgroup analyses. A risk of bias (RoB) assessment was performed using the Newcastle-Ottawa Scale (NOS). Results: Six cohort studies meeting our inclusion criteria were included (47,947 participants) in the study. From our meta-analysis, intravesical BCG vaccine administration lowered the risk of incidence of AD by 26% in non-muscle-invasive bladder cancer (p 75 years) and female participants. Conversely, significant heterogeneity in results was observed among male participants and those aged
- Published
- 2024
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