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Your search keyword '"Binion, D.G."' showing total 16 results
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16 results on '"Binion, D.G."'

3. Mucosal T-cell immunoregulation varies in early and late inflammatory bowel disease

Author

Kugathasan, S., Saubermann, L.J., Smith, L., Kou, D., Itoh, J., Binion, D.G., Levine, A.D., Blumberg, R.S., and Fiocchi, C.

Subjects
Crohn's disease -- Development and progression, Crohn's disease -- Physiological aspects, Crohn's disease -- Research, T cells -- Physiological aspects, T cells -- Research, Immune response -- Regulation, Immune response -- Research, Health
Published
2007

4. Antiangiogenic therapy in human gastrointestinal malignancies

Author

Heidemann, J., Binion, D.G., Domschke, W., and Kucharzik, T.

Subjects
Gastrointestinal diseases -- Care and treatment, Gastrointestinal diseases -- Diagnosis, Neovascularization -- Physiological aspects, Neovascularization -- Usage, Endothelial growth factors -- Physiological aspects, Biological markers -- Usage, Biological markers -- Physiological aspects, Health
Published
2006

5. 414 Treatment of refractory cutaneous Crohn’s disease with ustekinumab

Author

Patel, B.M., primary, Rivers, C. Ramos, additional, Koutroumpakis, F., additional, Ahsan, M., additional, Dueker, J., additional, Hashash, J., additional, Johnston, E., additional, Barrie, A., additional, Harrison, J., additional, Schwartz, M., additional, Babichenko, D., additional, Tang, G., additional, and Binion, D.G., additional

Published
2021
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7. Radiation induced small bowel 'web' formation is associated with acquired microvascular dysfunction

Author

Hatoum, O.A., Binion, D.G., Phillips, S.A., O'Loughlin, C., Komorowski, R.A., Gutterman, D.D., and Otterson, M.F.

Subjects
Radiotherapy -- Complications and side effects, Radiotherapy -- Reports, Microcirculation disorders -- Physiological aspects, Microcirculation disorders -- Development and progression, Intestines -- Obstructions, Intestines -- Development and progression, Health
Published
2005

9. Authors' reply

Author

Kugathasan, S., Saubermann, L.J., Smith, L., Kou, D., Itoh, J., Binion, D.G., Levine, A.D., Blumberg, R.S., and Fiocchi, C.

Subjects
Inflammatory bowel diseases -- Development and progression, Interleukin-12 -- Physiological aspects, Dendritic cells -- Physiological aspects, Health
Published
2008

10. Wisconsin statewide survey of pediatric IBD diagnosis in the year 2000: Changing patterns of Crohn's disease (CD) and ulcerative colitis (UC)

Author

Kugathasan, Subra, primary, Judd, Robert H., additional, Khan, Farrhat N., additional, Gourley, Glenn R., additional, Heikenen, Janice B., additional, Werlin, Steven L., additional, Brown, Christopher W., additional, Martinez, Alfonzo, additional, Blank, Ellen L., additional, Perreault, Jean F., additional, Yaffe, Michael R., additional, Park, Roger, additional, Rivera, M.T., additional, Telega, G, additional, Halibi, I, additional, Raasch, C, additional, and Binion, D.G., additional

Published
2001
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12. Intrinsic hyperreactivity of mucosal T cells to interleukin-2 in pediatric Crohn's disease

Author

Kugathasan, S., Willis, J., Dahms, B.B., O'Riordan, M.A., Hupertz, V., Binion, D.G., Boyle, J., and Fiocchi, C.

Abstract

Objectives: T cells play a crucial role in many chronic inflammatory diseases. Mucosal T cells are particularly important in the pathogenesis of Crohn's disease (CD). We investigated the response of T cells in CD and other intestinal inflammatory conditions to interleukin-2 (IL-2), a cytokine essential for T-cell activation, growth, and function. Study design: T-cell reactivity was assessed by measuring growth induced by IL-2 in mucosal endoscopic biopsy specimens obtained from children with CD, ulcerative colitis, indeterminate colitis, and chronic nonspecific colitis and from children without gastrointestinal inflammation. Results: CD mucosal T cells grew remarkably and significantly more than T cells from normal, ulcerative colitis, and chronic nonspecific colitis mucosa. T cells from indeterminate colitis mucosa grew similarly to those of CD mucosa. The enhanced growth response in CD was independent of disease location, presence or absence of intestinal inflammation, treatment, disease duration, or clinical activity. Conclusion: Mucosal T cells from children with CD exhibit an intrinsic hyperreactivity to IL-2. This may represent a primary pathogenic abnormality in this condition. (J Pediatr 1998;133:675-81)

Published
1998
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