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2. Genetic characterization of varicella-zoster and HIV-1 viruses from the cerebrospinal fluid of a co-infected encephalitic patient, Ghana

Author

El-Duah, Philip, Sylverken, Augustina Angelina, Owusu, Michael, Amoako, Yaw Ampem, Yeboah, Richmond, Gorman, Richmond, Nyarko-Afriyie, Emmanuella, Schneider, Julia, Jones, Terry C., Bonney, Joseph, Adade, Titus, Yeboah, Eric Smart, Binger, Tabea, Corman, Victor Max, Drosten, Christian, and Phillips, Richard Odame

Published
2022
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3. Transmission of SARS-CoV-2 in northern Ghana: insights from whole-genome sequencing

Author

Sylverken, Augustina Angelina, El-Duah, Philip, Owusu, Michael, Schneider, Julia, Yeboah, Richmond, Ayisi-Boateng, Nana Kwame, Gorman, Richmond, Adu, Eric, Kwarteng, Alexander, Frimpong, Michael, Binger, Tabea, Aryeetey, Sherihane, Asamoah, Jesse Addo, Amoako, Yaw Ampem, Amuasi, John Humphrey, Beheim-Schwarzbach, Jörn, Owusu-Dabo, Ellis, Adu-Sarkodie, Yaw, Obiri-Danso, Kwasi, Corman, Victor Max, Drosten, Christian, and Phillips, Richard

Published
2021
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7. Attenuation of replication by a 29 nucleotide deletion in SARS-coronavirus acquired during the early stages of human-to-human transmission

Author

Muth, Doreen, Corman, Victor Max, Roth, Hanna, Binger, Tabea, Dijkman, Ronald, Gottula, Lina Theresa, Gloza-Rausch, Florian, Balboni, Andrea, Battilani, Mara, Rihtarič, Danijela, Toplak, Ivan, Ameneiros, Ramón Seage, Pfeifer, Alexander, Thiel, Volker, Drexler, Jan Felix, Müller, Marcel Alexander, and Drosten, Christian

Published
2018
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8. Bats carry pathogenic hepadnaviruses antigenically related to hepatitis B virus and capable of infecting human hepatocytes

Author

Drexler, Jan Felix, Geipel, Andreas, König, Alexander, Corman, Victor M., van Riel, Debby, Leijten, Lonneke M., Bremer, Corinna M., Rasche, Andrea, Cottontail, Veronika M., Magangaf, Gael D., Schlegel, Mathias, Müller, Marcel A., Adam, Alexander, Klose, Stefan M., Carneiro, Aroldo José Borges, Stöcker, Andreas, Franke, Carlos Roberto, Rausch, Florian Gloza, Geyer, Joachim, Annan, Augustina, Adu-Sarkodie, Yaw, Oppongn, Samuel, Binger, Tabea, Vallo, Peter, Tschapka, Marco, Ulrich, Rainer G., Gerlich, Wolfram H., Leroy, Eric, Kuiken, Thijs, Glebe, Dieter, and Drosten, Christian

Published
2013

9. Additional file 1 of Genetic characterization of varicella-zoster and HIV-1 viruses from the cerebrospinal fluid of a co-infected encephalitic patient, Ghana

Author

El-Duah, Philip, Sylverken, Augustina Angelina, Owusu, Michael, Amoako, Yaw Ampem, Yeboah, Richmond, Gorman, Richmond, Nyarko-Afriyie, Emmanuella, Schneider, Julia, Jones, Terry C., Bonney, Joseph, Adade, Titus, Yeboah, Eric Smart, Binger, Tabea, Corman, Victor Max, Drosten, Christian, and Phillips, Richard Odame

Abstract

Additional file 1. Table S1. FASTA sequences of HIV-1 fragments used in phylogenetic analysis.

Published
2022
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11. At least seven distinct rotavirus genotype constellations in bats with evidence of reassortment and zoonotic transmissions

Author

Simsek, Ceren, Corman, Victor Max, Everling, Hermann Ulrich, Lukashev, Alexander N., Rasche, Andrea, Maganga, Gaël Darren, Binger, Tabea, Jansen, Daan, Beller, Leen, Deboutte, Ward, Gloza-Rausch, Florian, Seebens-Hoyer, Antje, Yordanov, Stoian, Sylverken, Augustina, Oppong, Samuel, Adu Sarkodie, Yaw, Vallo, Peter, Leroy, Eric M., Bourgarel, Mathieu, Yinda, Kwe Claude, Van Ranst, Eric, Drosten, Christian, Drexler, Jan Felix, Matthijnssens, Jelle, Simsek, Ceren, Corman, Victor Max, Everling, Hermann Ulrich, Lukashev, Alexander N., Rasche, Andrea, Maganga, Gaël Darren, Binger, Tabea, Jansen, Daan, Beller, Leen, Deboutte, Ward, Gloza-Rausch, Florian, Seebens-Hoyer, Antje, Yordanov, Stoian, Sylverken, Augustina, Oppong, Samuel, Adu Sarkodie, Yaw, Vallo, Peter, Leroy, Eric M., Bourgarel, Mathieu, Yinda, Kwe Claude, Van Ranst, Eric, Drosten, Christian, Drexler, Jan Felix, and Matthijnssens, Jelle

Abstract

Bats host many viruses pathogenic to humans, and increasing evidence suggests that rotavirus A (RVA) also belongs to this list. Rotaviruses cause diarrheal disease in many mammals and birds, and their segmented genomes allow them to reassort and increase their genetic diversity. Eighteen out of 2,142 bat fecal samples (0.8%) collected from Europe, Central America, and Africa were PCR-positive for RVA, and 11 of those were fully characterized using viral metagenomics. Upon contrasting their genomes with publicly available data, at least 7 distinct bat RVA genotype constellations (GCs) were identified, which included evidence of reassortments and 6 novel genotypes. Some of these constellations are spread across the world, whereas others appear to be geographically restricted. Our analyses also suggest that several unusual human and equine RVA strains might be of bat RVA origin, based on their phylogenetic clustering, despite various levels of nucleotide sequence identities between them. Although SA11 is one of the most widely used reference strains for RVA research and forms the backbone of a reverse genetics system, its origin remained enigmatic. Remarkably, the majority of the genotypes of SA11-like strains were shared with Gabonese bat RVAs, suggesting a potential common origin. Overall, our findings suggest an underexplored genetic diversity of RVAs in bats, which is likely only the tip of the iceberg. Increasing contact between humans and bat wildlife will further increase the zoonosis risk, which warrants closer attention to these viruses. IMPORTANCE The increased research on bat coronaviruses after severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) allowed the very rapid identification of SARS-CoV-2. This is an excellent example of the importance of knowing viruses harbored by wildlife in general, and bats in particular, for global preparedness against emerging viral pathogens. The current effort

Published
2021

12. At Least Seven Distinct Rotavirus Genotype Constellations in Bats with Evidence of Reassortment and Zoonotic Transmissions

Author

Simsek, Ceren, primary, Corman, Victor Max, additional, Everling, Hermann Ulrich, additional, Lukashev, Alexander N., additional, Rasche, Andrea, additional, Maganga, Gael Darren, additional, Binger, Tabea, additional, Jansen, Daan, additional, Beller, Leen, additional, Deboutte, Ward, additional, Gloza-Rausch, Florian, additional, Seebens-Hoyer, Antje, additional, Yordanov, Stoian, additional, Sylverken, Augustina, additional, Oppong, Samuel, additional, Sarkodie, Yaw Adu, additional, Vallo, Peter, additional, Leroy, Eric M., additional, Bourgarel, Mathieu, additional, Yinda, Kwe Claude, additional, Van Ranst, Marc, additional, Drosten, Christian, additional, Drexler, Jan Felix, additional, and Matthijnssens, Jelle, additional

Published
2021
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13. Diagnostics for COVID-19: A case for field-deployable, rapid molecular tests for community surveillance

Author

Frimpong, Michael, primary, A. Amoako, Yaw, additional, B. Anim, Kwadwo, additional, S. Ahor, Hubert, additional, Yeboah, Richmond, additional, Arthur, Joshua, additional, S. Dakorah, Justin, additional, Gborgblovor, Delphine, additional, Akrofi, Samuel, additional, Sekyi- Djan, Phyllis, additional, Owusu, Michael, additional, A. Sylverken, Augustina, additional, Binger, Tabea, additional, and O. Phillips, Richard, additional

Published
2020
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14. Epidemiological profile of SARS-CoV-2 among selected regions in Ghana: A cross-sectional retrospective study

Author

Owusu, Michael, primary, Sylverken, Augustina Angelina, additional, Ankrah, Sampson Twumasi, additional, El-Duah, Philip, additional, Ayisi-Boateng, Nana Kwame, additional, Yeboah, Richmond, additional, Gorman, Richmond, additional, Asamoah, Jesse, additional, Binger, Tabea, additional, Acheampong, Godfred, additional, Bekoe, Franklin Asiedu, additional, Ohene, Sally-Ann, additional, Larsen-Reindorf, Rita, additional, Awuah, Anthony Afum-Adjei, additional, Amuasi, John, additional, Owusu-Dabo, Ellis, additional, Adu-Sarkodie, Yaw, additional, and Phillips, Richard Odame, additional

Published
2020
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15. At least seven distinct rotavirus genotype constellations in bats with evidence of reassortment and zoonotic transmissions

Author

Simsek, Ceren, primary, Corman, Victor Max, additional, Everling, Hermann Ulrich, additional, Lukashev, Alexander N., additional, Rasche, Andrea, additional, Maganga, Gael Darren, additional, Binger, Tabea, additional, Jansen, Daan, additional, Beller, Leen, additional, Deboutte, Ward, additional, Gloza-Rausch, Florian, additional, Seebens-Hoyer, Antje, additional, Yordanov, Stoian, additional, Sylverken, Augustina, additional, Oppong, Samuel, additional, Sarkodie, Yaw Adu, additional, Vallo, Peter, additional, Leroy, Eric M., additional, Bourgarel, Mathieu, additional, Yinda, Kwe Claude, additional, Van Ranst, Marc, additional, Drosten, Christian, additional, Drexler, Jan Felix, additional, and Matthijnssens, Jelle, additional

Published
2020
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16. Malaria Coinfections in Febrile Pediatric Inpatients: A Hospital-Based Study From Ghana

Author

Hogan, Benedikt, Eibach, Daniel, Krumkamp, Ralf, Sarpong, Nimako, Dekker, Denise, Kreuels, Benno, Maiga-Ascofaré, Oumou, Gyau Boahen, Kennedy, Wiafe Akenten, Charity, Adu-Sarkodie, Yaw, Owusu-Dabo, Ellis, May, Jürgen, Ammer, Luise, Struck, Nicole, Hahn, Andreas, Herr, Wiebke, Jaeger, Anna, Levermann, Vinzent, Loag, Wibke, Mertens, Eva, Reigl, Lisa, Steierberg, Stefanie, Winter, Doris, Al-Emran, Hassan, Boateng, Harry Owusu, Rettig, Theresa, Binger, Tabea, Hanson, Henry, Oppong, Kwabena, Nagel, Michael, Aepfelbacher, Martin, Buehl, Henrike, Henrichfreise, Beate, Cadar, Daniel, Eckerle, Isabella, Drosten, Christian, Ittrich, Harald, Tannich, Egbert, Thielebei, Anke, and Eckerle, Isabella Anne

Subjects
0301 basic medicine, Male, Gastrointestinal Diseases, Parasitemia, medicine.disease_cause, Ghana, Parasite Load, Malaria/epidemiology/microbiology/virology, 0302 clinical medicine, Cost of Illness, Rotavirus, Epidemiology, Prospective Studies, Child, Urinary Tract Infections/epidemiology/microbiology, Articles and Commentaries, Respiratory Tract Infections, fever, Respiratory tract infections, Coinfection, Hospitalization, Infectious Diseases, Child, Preschool, Urinary Tract Infections, Female, Fever/etiology/parasitology, Microbiology (medical), medicine.medical_specialty, Adolescent, 030231 tropical medicine, malaria, 03 medical and health sciences, children, Internal medicine, Streptococcus pneumoniae, parasitic diseases, medicine, Coinfection/epidemiology, Humans, Gastrointestinal Diseases/epidemiology/virology, Ghana/epidemiology, Respiratory Tract Infections/epidemiology/microbiology, business.industry, Infant, medicine.disease, Parasitemia/epidemiology, Pneumonia, 030104 developmental biology, Africa, business, Malaria
Abstract

In malaria patients admitted to the study hospital, the likelihood of a co-diagnosis decreased with an increasing parasite count. In malaria-endemic settings, parasite densities provide important information for patient management, in particular for antimicrobial medication., Background The epidemiology of pediatric febrile illness is shifting in sub-Saharan Africa, but malaria remains a major cause of childhood morbidity and mortality. The present study describes causes of febrile illness in hospitalized children in Ghana and aims to determine the burden of malaria coinfections and their association with parasite densities. Methods In a prospective study, children (aged ≥30 days and ≤15 years) with fever ≥38.0°C were recruited after admission to the pediatric ward of a primary hospital in Ghana. Malaria parasitemia was determined and blood, stool, urine, respiratory, and cerebrospinal fluid specimens were screened for parasitic, bacterial, and viral pathogens. Associations of Plasmodium densities with other pathogens were calculated. Results From November 2013 to April 2015, 1238 children were enrolled from 4169 admissions. A clinical/microbiological diagnosis could be made in 1109/1238 (90%) patients, with Plasmodium parasitemia (n = 728/1238 [59%]) being predominant. This was followed by lower respiratory tract infections/pneumonia (n = 411/1238 [34%]; among detected pathogens most frequently Streptococcus pneumoniae, n = 192/299 [64%]), urinary tract infections (n = 218/1238 [18%]; Escherichia coli, n = 21/32 [66%]), gastrointestinal infections (n = 210 [17%]; rotavirus, n = 32/97 [33%]), and invasive bloodstream infections (n = 62 [5%]; Salmonella species, n = 47 [76%]). In Plasmodium-infected children the frequency of lower respiratory tract, gastrointestinal, and bloodstream infections increased with decreasing parasite densities. Conclusions In a hospital setting, the likelihood of comorbidity with a nonmalarial disease is inversely correlated with increasing blood levels of malaria parasites. Hence, parasite densities provide important information as an indicator for the probability of coinfection, in particular to guide antimicrobial medication.

Published
2018

18. Burden of influenza among hospitalized febrile children in Ghana

Author

Hogan, Benedikt, primary, Ammer, Luise, additional, Zimmermann, Marlow, additional, Binger, Tabea, additional, Krumkamp, Ralf, additional, Sarpong, Nimako, additional, Rettig, Theresa, additional, Dekker, Denise, additional, Kreuels, Benno, additional, Reigl, Lisa, additional, Boahen, Kennedy G., additional, Wiafe, Charity, additional, Adu-Sarkodie, Yaw, additional, Owusu-Dabo, Ellis, additional, May, Jürgen, additional, and Eibach, Daniel, additional

Published
2017
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19. Evidence for widespread infection of African bats with Crimean-Congo hemorrhagic fever-like viruses

Author

Müller, Marcel A., primary, Devignot, Stéphanie, additional, Lattwein, Erik, additional, Corman, Victor Max, additional, Maganga, Gaël D., additional, Gloza-Rausch, Florian, additional, Binger, Tabea, additional, Vallo, Peter, additional, Emmerich, Petra, additional, Cottontail, Veronika M., additional, Tschapka, Marco, additional, Oppong, Samuel, additional, Drexler, Jan Felix, additional, Weber, Friedemann, additional, Leroy, Eric M., additional, and Drosten, Christian, additional

Published
2016
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20. Corrigendum: Bats host major mammalian paramyxoviruses

Author

Drexler, Jan Felix, Corman, Victor Max, Müller, Marcel Alexander, Maganga, Gael Darren, Vallo, Peter, Binger, Tabea, Gloza-Rausch, Florian, Cottontail, Veronika M., Rasche, Andrea, Yordanov, Stoian, Seebens, Antje, Knörnschild, Mirjam, Oppong, Samuel, Sarkodie, Yaw Adu, Pongombo, Célestin, Lukashev, Alexander N., Schmidt-Chanasit, Jonas, Stöcker, Andreas, Carneiro, Aroldo José Borges, Erbar, Stephanie, Maisner, Andrea, Fronhoffs, Florian, Buettner, Reinhard, Kalko, Elisabeth K. V., Kruppa, Thomas, Franke, Carlos Roberto, Kallies, René, Yandoko, Emmanuel R. N., Herrler, Georg, Reusken, Chantal, Hassanin, Alexandre, Krüger, Detlev H., Matthee, Sonja, Ulrich, Rainer G., Leroy, Eric M., and Drosten, Christian

Subjects
Corrigenda
Published
2014

21. Nature Communications

Author

Carneiro, Aroldo José Borges, Franke, Carlos Roberto, Drexler, Jan Felix, Corman, Victor Max, Müller, Marcel Alexander, Maganga, Gael Darren, Vallo, Peter, and Binger, Tabea

Abstract

Texto completo: acesso restrito. p. 1-12 Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-08-11T13:30:20Z No. of bitstreams: 1 Aroldo José Borges Carneiro.pdf: 888485 bytes, checksum: dd2b5fa5aad29f8a17f618484840eeac (MD5) Rejected by Patricia Barroso (pbarroso@ufba.br), reason: Prezados autores, Solicitamos a inclusão com brevidade das palavras chave de seu artigo e a realização de um novo depósito para validação. on 2014-08-11T19:00:14Z (GMT) Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-08-12T15:09:25Z No. of bitstreams: 1 Aroldo José Borges Carneiro.pdf: 888485 bytes, checksum: dd2b5fa5aad29f8a17f618484840eeac (MD5) Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2014-08-12T15:16:28Z (GMT) No. of bitstreams: 1 Aroldo José Borges Carneiro.pdf: 888485 bytes, checksum: dd2b5fa5aad29f8a17f618484840eeac (MD5) Made available in DSpace on 2014-08-12T15:16:28Z (GMT). No. of bitstreams: 1 Aroldo José Borges Carneiro.pdf: 888485 bytes, checksum: dd2b5fa5aad29f8a17f618484840eeac (MD5) Previous issue date: 2012 The large virus family Paramyxoviridae includes some of the most significant human and livestock viruses, such as measles-, distemper-, mumps-, parainfluenza-, Newcastle disease-, respiratory syncytial virus and metapneumoviruses. Here we identify an estimated 66 new paramyxoviruses in a worldwide sample of 119 bat and rodent species (9,278 individuals). Major discoveries include evidence of an origin of Hendra- and Nipah virus in Africa, identification of a bat virus conspecific with the human mumps virus, detection of close relatives of respiratory syncytial virus, mouse pneumonia- and canine distemper virus in bats, as well as direct evidence of Sendai virus in rodents. Phylogenetic reconstruction of host associations suggests a predominance of host switches from bats to other mammals and birds. Hypothesis tests in a maximum likelihood framework permit the phylogenetic placement of bats as tentative hosts at ancestral nodes to both the major Paramyxoviridae subfamilies (Paramyxovirinae and Pneumovirinae). Future attempts to predict the emergence of novel paramyxoviruses in humans and livestock will have to rely fundamentally on these data.

Published
2012
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22. Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats

Author

Ng, Melinda, primary, Ndungo, Esther, additional, Kaczmarek, Maria E, additional, Herbert, Andrew S, additional, Binger, Tabea, additional, Kuehne, Ana I, additional, Jangra, Rohit K, additional, Hawkins, John A, additional, Gifford, Robert J, additional, Biswas, Rohan, additional, Demogines, Ann, additional, James, Rebekah M, additional, Yu, Meng, additional, Brummelkamp, Thijn R, additional, Drosten, Christian, additional, Wang, Lin-Fa, additional, Kuhn, Jens H, additional, Müller, Marcel A, additional, Dye, John M, additional, Sawyer, Sara L, additional, and Chandran, Kartik, additional

Published
2015
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23. Author response: Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats

Author

Ng, Melinda, primary, Ndungo, Esther, additional, Kaczmarek, Maria E, additional, Herbert, Andrew S, additional, Binger, Tabea, additional, Kuehne, Ana I, additional, Jangra, Rohit K, additional, Hawkins, John A, additional, Gifford, Robert J, additional, Biswas, Rohan, additional, Demogines, Ann, additional, James, Rebekah M, additional, Yu, Meng, additional, Brummelkamp, Thijn R, additional, Drosten, Christian, additional, Wang, Lin-Fa, additional, Kuhn, Jens H, additional, Müller, Marcel A, additional, Dye, John M, additional, Sawyer, Sara L, additional, and Chandran, Kartik, additional

Published
2015
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24. Viral Shedding and Antibody Response in 37 Patients With Middle East Respiratory Syndrome Coronavirus Infection

Author

Corman, Victor M., primary, Albarrak, Ali M., additional, Omrani, Ali Senosi, additional, Albarrak, Mohammed M., additional, Farah, Mohamed Elamin, additional, Almasri, Malak, additional, Muth, Doreen, additional, Sieberg, Andrea, additional, Meyer, Benjamin, additional, Assiri, Abdullah M., additional, Binger, Tabea, additional, Steinhagen, Katja, additional, Lattwein, Erik, additional, Al-Tawfiq, Jaffar, additional, Müller, Marcel A., additional, Drosten, Christian, additional, and Memish, Ziad A., additional

Published
2015
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25. Highly Divergent Hepaciviruses from African Cattle

Author

Corman, Victor Max, primary, Grundhoff, Adam, additional, Baechlein, Christine, additional, Fischer, Nicole, additional, Gmyl, Anatoly, additional, Wollny, Robert, additional, Dei, Dickson, additional, Ritz, Daniel, additional, Binger, Tabea, additional, Adankwah, Ernest, additional, Marfo, Kwadwo Sarfo, additional, Annison, Lawrence, additional, Annan, Augustina, additional, Adu-Sarkodie, Yaw, additional, Oppong, Samuel, additional, Becher, Paul, additional, Drosten, Christian, additional, and Drexler, Jan Felix, additional

Published
2015
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26. Serological Evidence of Influenza A Viruses in Frugivorous Bats from Africa

Author

Freidl, Gudrun Stephanie, primary, Binger, Tabea, additional, Müller, Marcel Alexander, additional, de Bruin, Erwin, additional, van Beek, Janko, additional, Corman, Victor Max, additional, Rasche, Andrea, additional, Drexler, Jan Felix, additional, Sylverken, Augustina, additional, Oppong, Samuel K., additional, Adu-Sarkodie, Yaw, additional, Tschapka, Marco, additional, Cottontail, Veronika M., additional, Drosten, Christian, additional, and Koopmans, Marion, additional

Published
2015
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27. A Novel Rhabdovirus Isolated from the Straw-Colored Fruit Bat Eidolon helvum, with Signs of Antibodies in Swine and Humans

Author

Binger, Tabea, primary, Annan, Augustina, additional, Drexler, Jan Felix, additional, Müller, Marcel Alexander, additional, Kallies, René, additional, Adankwah, Ernest, additional, Wollny, Robert, additional, Kopp, Anne, additional, Heidemann, Hanna, additional, Dei, Dickson, additional, Agya-Yao, Festus Courage, additional, Junglen, Sandra, additional, Feldt, Torsten, additional, Kurth, Andreas, additional, Oppong, Samuel, additional, Adu-Sarkodie, Yaw, additional, and Drosten, Christian, additional

Published
2015
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28. Evidence for novel hepaciviruses in rodents

Author

Drexler, Jan Felix, Corman, Victor Max, Müller, Marcel Alexander, Lukashev, Alexander N., Gmyl, Anatoly, Coutard, Bruno, Adam, Alexander, Ritz, Daniel, Leijten, Lonneke M., Van Riel, Debby, Kallies, Rene, Klose, Stefan M., Gloza-Rausch, Florian, Binger, Tabea, Annan, Augustina, Adu-Sarkodie, Yaw, Oppong, Samuel, Bourgarel, Mathieu, Rupp, Daniel, Hoffmann, Bernd, Schlegel, Mathias, Kümmerer, Beate M., Krüger, Detlev H., Schmidt-chanasit, Jonas, Aguilar Setién, Alvaro, Cottontail, Veronika M., Hemachudha, Thiravat, Wacharapluesadee, Supaporn, Osterrieder, Klaus, Bartenschlager, Ralf, Matthee, Sonja, Beer, Martin, Kuilen, Thijs, Reusken, Chantal, Leroy, Eric M., Ulrich, Rainer G., Drosten, Christian, Drexler, Jan Felix, Corman, Victor Max, Müller, Marcel Alexander, Lukashev, Alexander N., Gmyl, Anatoly, Coutard, Bruno, Adam, Alexander, Ritz, Daniel, Leijten, Lonneke M., Van Riel, Debby, Kallies, Rene, Klose, Stefan M., Gloza-Rausch, Florian, Binger, Tabea, Annan, Augustina, Adu-Sarkodie, Yaw, Oppong, Samuel, Bourgarel, Mathieu, Rupp, Daniel, Hoffmann, Bernd, Schlegel, Mathias, Kümmerer, Beate M., Krüger, Detlev H., Schmidt-chanasit, Jonas, Aguilar Setién, Alvaro, Cottontail, Veronika M., Hemachudha, Thiravat, Wacharapluesadee, Supaporn, Osterrieder, Klaus, Bartenschlager, Ralf, Matthee, Sonja, Beer, Martin, Kuilen, Thijs, Reusken, Chantal, Leroy, Eric M., Ulrich, Rainer G., and Drosten, Christian

Abstract

Hepatitis C virus (HCV) is among the most relevant causes of liver cirrhosis and hepatocellular carcinoma. Research is complicated by a lack of accessible small animal models. The systematic investigation of viruses of small mammals could guide efforts to establish such models, while providing insight into viral evolutionary biology. We have assembled the so-far largest collection of small-mammal samples from around the world, qualified to be screened for bloodborne viruses, including sera and organs from 4,770 rodents (41 species); and sera from 2,939 bats (51 species). Three highly divergent rodent hepacivirus clades were detected in 27 (1.8%) of 1,465 European bank voles (Myodes glareolus) and 10 (1.9%) of 518 South African four-striped mice (Rhabdomys pumilio). Bats showed anti-HCV immunoblot reactivities but no virus detection, although the genetic relatedness suggested by the serologic results should have enabled RNA detection using the broadly reactive PCR assays developed for this study. 210 horses and 858 cats and dogs were tested, yielding further horseassociated hepaciviruses but none in dogs or cats. The rodent viruses were equidistant to HCV, exceeding by far the diversity of HCV and the canine/equine hepaciviruses taken together. Five full genomes were sequenced, representing all viral lineages. Salient genome features and distance criteria supported classification of all viruses as hepaciviruses. Quantitative RT-PCR, RNA in-situ hybridisation, and histopathology suggested hepatic tropism with liver inflammation resembling hepatitis C. Recombinant serology for two distinct hepacivirus lineages in 97 bank voles identified seroprevalence rates of 8.3 and 12.4%, respectively. Antibodies in bank vole sera neither cross-reacted with HCV, nor the heterologous bank vole hepacivirus. Co-occurrence of RNA and antibodies was found in 3 of 57 PCR-positive bank vole sera (5.3%). Our data enable new hypotheses regarding HCV evolution and encourage efforts to develo

Published
2013

29. Correction: Corrigendum: Bats host major mammalian paramyxoviruses

Author

Drexler, Jan Felix, primary, Corman, Victor Max, additional, Müller, Marcel Alexander, additional, Maganga, Gael Darren, additional, Vallo, Peter, additional, Binger, Tabea, additional, Gloza-Rausch, Florian, additional, Cottontail, Veronika M., additional, Rasche, Andrea, additional, Yordanov, Stoian, additional, Seebens, Antje, additional, Knörnschild, Mirjam, additional, Oppong, Samuel, additional, Sarkodie, Yaw Adu, additional, Pongombo, Célestin, additional, Lukashev, Alexander N., additional, Schmidt-Chanasit, Jonas, additional, Stöcker, Andreas, additional, Carneiro, Aroldo José Borges, additional, Erbar, Stephanie, additional, Maisner, Andrea, additional, Fronhoffs, Florian, additional, Buettner, Reinhard, additional, Kalko, Elisabeth K. V., additional, Kruppa, Thomas, additional, Franke, Carlos Roberto, additional, Kallies, René, additional, Yandoko, Emmanuel R. N., additional, Herrler, Georg, additional, Reusken, Chantal, additional, Hassanin, Alexandre, additional, Krüger, Detlev H., additional, Matthee, Sonja, additional, Ulrich, Rainer G., additional, Leroy, Eric M., additional, and Drosten, Christian, additional

Published
2014
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30. Differential Sensitivity of Bat Cells to Infection by Enveloped RNA Viruses: Coronaviruses, Paramyxoviruses, Filoviruses, and Influenza Viruses

Author

Hoffmann, Markus, primary, Müller, Marcel Alexander, additional, Drexler, Jan Felix, additional, Glende, Jörg, additional, Erdt, Meike, additional, Gützkow, Tim, additional, Losemann, Christoph, additional, Binger, Tabea, additional, Deng, Hongkui, additional, Schwegmann-Weßels, Christel, additional, Esser, Karl-Heinz, additional, Drosten, Christian, additional, and Herrler, Georg, additional

Published
2013
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31. Evidence for Novel Hepaciviruses in Rodents

Author

Drexler, Jan Felix, primary, Corman, Victor Max, additional, Müller, Marcel Alexander, additional, Lukashev, Alexander N., additional, Gmyl, Anatoly, additional, Coutard, Bruno, additional, Adam, Alexander, additional, Ritz, Daniel, additional, Leijten, Lonneke M., additional, van Riel, Debby, additional, Kallies, Rene, additional, Klose, Stefan M., additional, Gloza-Rausch, Florian, additional, Binger, Tabea, additional, Annan, Augustina, additional, Adu-Sarkodie, Yaw, additional, Oppong, Samuel, additional, Bourgarel, Mathieu, additional, Rupp, Daniel, additional, Hoffmann, Bernd, additional, Schlegel, Mathias, additional, Kümmerer, Beate M., additional, Krüger, Detlev H., additional, Schmidt-Chanasit, Jonas, additional, Setién, Alvaro Aguilar, additional, Cottontail, Veronika M., additional, Hemachudha, Thiravat, additional, Wacharapluesadee, Supaporn, additional, Osterrieder, Klaus, additional, Bartenschlager, Ralf, additional, Matthee, Sonja, additional, Beer, Martin, additional, Kuiken, Thijs, additional, Reusken, Chantal, additional, Leroy, Eric M., additional, Ulrich, Rainer G., additional, and Drosten, Christian, additional

Published
2013
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32. Viral Shedding and Antibody Response in 37 PatientsWith Middle East Respiratory Syndrome Coronavirus Infection.

Author

Corman, Victor M., Albarrak, Ali M., Omrani, Ali Senosi, Albarrak, Mohammed M., Farah, Mohamed Elamin, Almasri, Malak, Muth, Doreen, Sieberg, Andrea, Meyer, Benjamin, Assiri, Abdullah M., Binger, Tabea, Steinhagen, Katja, Lattwein, Erik, Al-Tawfiq, Jaffar, Müller, Marcel A., Drosten, Christian, and Memish, Ziad A.

Subjects
VIRAL shedding, ANTIBODY formation, MIDDLE East respiratory syndrome, MERS coronavirus, IMMUNOGLOBULIN M, DIAGNOSIS
Abstract

Background. The Middle East respiratory syndrome (MERS) coronavirus causes isolated cases and outbreaks of severe respiratory disease. Essential features of the natural history of disease are poorly understood. Methods. We studied 37 adult patients infected with MERS coronavirus for viral load in the lower and upper respiratory tracts (LRT and URT, respectively), blood, stool, and urine. Antibodies and serum neutralizing activities were determined over the course of disease. Results. One hundred ninety-nine LRT samples collected during the 3 weeks following diagnosis yielded virus RNA in 93% of tests. Average (maximum) viral loads were 5 × 106 (6 × 1010) copies/mL. Viral loads ( positive detection frequencies) in 84 URT samples were 1.9 × 104 copies/mL (47.6%). Thirty-three percent of all 108 serum samples tested yielded viral RNA. Only 14.6% of stool and 2.4% of urine samples yielded viral RNA. All seroconversions occurred during the first 2 weeks after diagnosis, which corresponds to the second and third week after symptom onset. Immunoglobulin M detection provided no advantage in sensitivity over immunoglobulin G (IgG) detection. All surviving patients, but only slightly more than half of all fatal cases, produced IgG and neutralizing antibodies. The levels of IgG and neutralizing antibodies were weakly and inversely correlated with LRT viral loads. Presence of antibodies did not lead to the elimination of virus from LRT. Conclusions. The timing and intensity of respiratory viral shedding in patients with MERS closely matches that of those with severe acute respiratory syndrome. Blood viral RNA does not seem to be infectious. Extrapulmonary loci of virus replication seem possible. Neutralizing antibodies do not suffice to clear the infection. [ABSTRACT FROM AUTHOR]

Published
2016
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33. Human Coronavirus EMC Does Not Require the SARS-Coronavirus Receptor and Maintains Broad Replicative Capability in Mammalian Cell Lines

Author

Müller, Marcel A., primary, Raj, V. Stalin, additional, Muth, Doreen, additional, Meyer, Benjamin, additional, Kallies, Stephan, additional, Smits, Saskia L., additional, Wollny, Robert, additional, Bestebroer, Theo M., additional, Specht, Sabine, additional, Suliman, Tasnim, additional, Zimmermann, Katrin, additional, Binger, Tabea, additional, Eckerle, Isabella, additional, Tschapka, Marco, additional, Zaki, Ali M., additional, Osterhaus, Albert D. M. E., additional, Fouchier, Ron A. M., additional, Haagmans, Bart L., additional, and Drosten, Christian, additional

Published
2012
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34. Bats host major mammalian paramyxoviruses

Author

Drexler, Jan Felix, primary, Corman, Victor Max, additional, Müller, Marcel Alexander, additional, Maganga, Gael Darren, additional, Vallo, Peter, additional, Binger, Tabea, additional, Gloza-Rausch, Florian, additional, Cottontail, Veronika M., additional, Rasche, Andrea, additional, Yordanov, Stoian, additional, Seebens, Antje, additional, Knörnschild, Mirjam, additional, Oppong, Samuel, additional, Sarkodie, Yaw Adu, additional, Pongombo, Célestin, additional, Lukashev, Alexander N., additional, Schmidt-Chanasit, Jonas, additional, Stöcker, Andreas, additional, Carneiro, Aroldo José Borges, additional, Erbar, Stephanie, additional, Maisner, Andrea, additional, Fronhoffs, Florian, additional, Buettner, Reinhard, additional, Kalko, Elisabeth K. V., additional, Kruppa, Thomas, additional, Franke, Carlos Roberto, additional, Kallies, René, additional, Yandoko, Emmanuel R.N., additional, Herrler, Georg, additional, Reusken, Chantal, additional, Hassanin, Alexandre, additional, Krüger, Detlev H., additional, Matthee, Sonja, additional, Ulrich, Rainer G., additional, Leroy, Eric M., additional, and Drosten, Christian, additional

Published
2012
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36. Attenuation of replication by a 29 nucleotide deletion in SARS-coronavirus acquired during the early stages of human-to-human transmission

Author

Muth, Doreen, Corman, Victor Max, Roth, Hanna, Binger, Tabea, Dijkman, Ronald, Gottula, Lina Theresa, Gloza-Rausch, Florian, Balboni, Andrea, Battilani, Mara, Rihtarič, Danijela, Toplak, Ivan, Ameneiros, Ramon Seage, Pfeifer, Alexander, Thiel, Volker, Drexler, Jan Felix, Mueller, Marcel Alexander, and Drosten, Christian

Subjects
SARS-coronavirus, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, 3. Good health
Abstract

A 29 nucleotide deletion in open reading frame 8 (ORF8) is the most obvious genetic change in severe acute respiratory syndrome coronavirus (SARS-CoV) during its emergence in humans. In spite of intense study, it remains unclear whether the deletion actually reflects adaptation to humans. Here we engineered full, partially deleted (-29 nt), and fully deleted ORF8 into a SARS-CoV infectious cDNA clone, strain Frankfurt-1. Replication of the resulting viruses was compared in primate cell cultures as well as Rhinolophus bat cells made permissive for SARS-CoV replication by lentiviral transduction of the human angiotensin-converting enzyme 2 receptor. Cells from cotton rat, goat, and sheep provided control scenarios that represent host systems in which SARS-CoV is neither endemic nor epidemic. Independent of the cell system, the truncation of ORF8 (29 nt deletion) decreased replication up to 23-fold. The effect was independent of the type I interferon response. The 29 nt deletion in SARS-CoV is a deleterious mutation acquired along the initial human-to-human transmission chain. The resulting loss of fitness may be due to a founder effect, which has rarely been documented in processes of viral emergence. These results have important implications for the retrospective assessment of the threat posed by SARS.

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