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Rapid preparation of nanocrystalline γ-Fe2O3 powder with superparamagnetism was realized by cryomilling commercial Fe2O3 powder using liquid nitrogen. The effects of milling temperature and duration on the grain size, phase and microstructure of the nanocrystalline Fe2O3 powder were analyzed. Magnetic property of the nanocrystalline γ-Fe2O3 powder was also tested by magnetometer at room temperature. The results demonstrate that nanocrystalline γ-Fe2O3 powder with single phase can be prepared rapidly by cryomilling with liquid nitrogen. The mean particle size of γ-Fe2O3 powder can be reduced from 300 nm to 13 nm by cryomilling at −130 °C within 3 hours. The nanocrystalline γ-Fe2O3 powder shows superparamagnetism at room temperature.

Yb-doped titanium dioxide nanoparticles were synthesized using collagen as the template, and characterized by means of X-ray diffraction (XRD), transmission electron microscopy (TEM), UV-Vis spectrophotometry, and Fourier transform infrared (FT-IR) spectra. The effect of doping concentration and calcination temperature on structure of TiO2was discussed. The results showed the Yb-TiO2nanoparticles have high crystallinity with the size of 18-28 nm. Ytterbium doping could inhibit the phase transformation from anatase to rutile of TiO2, reduce the crystallite size, improve thermal stability, and improve the light absorption. This study indicates that collagen could be used as an ideal biological template to prepare metal oxide nanoparticles with high crystallinity.

AIM: To observe the adsorbent effect of resin on endotoxin, cytokine, bilirubin in plasma of patients with hepatic failure and to determine the resin perfusion as an artificial liver support system in the treatment of hepatic failure. METHODS: One thousand milliliters of discarded plasma was collected from each of 6 severe hepatitis patients treated with plasma exchange. The plasma was passed through a resin perfusion equipment for 1-2 h via extracorporeal circulation, and then absorbent indicators of transaminase, bilirubin, blood ammonia, endotoxin and cytokines were examined. In the meantime, study of in vivo resin plasma perfusion was performed on 7 severe hepatitis patients to compare the changes of endotoxin and cytokines in blood before and after perfusion. RESULTS: The levels of total bilirubin, endotoxin, interleukin 1β and TNF-α in plasma were significantly decreased after in vitro resin plasma perfusion. The levels of interleukin 1β, TNF-α and endotoxin in blood were also evidently declined after in vivo resin plasma perfusion. Nevertheless, no obvious changes in IL-6, creatinine (Cr) and urea nitrogen (UN), blood ammonia and electrolytes were found both in vitro and in vivo. CONCLUSION: Bilirubin, endotoxin and cytokines in plasma of patients with hepatic failure can be effectively adsorbed by resin in vitro. Most cytokines and endotoxin in plasma can also be effectively removed by resin in vivo. It demonstrates that resin perfusion may have good treatment efficacy on hepatic failure and can be expected to slow down the progression of hepatic failure.