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2. Role of the V2R–βarrestin–Gβγ complex in promoting G protein translocation to endosomes

Author

Badr Sokrat, Anthony H. Nguyen, Alex R. B. Thomsen, Li-Yin Huang, Hiroyuki Kobayashi, Alem W. Kahsai, Jihee Kim, Bing X. Ho, Symon Ma, John Little, Catherine Ehrhart, Ian Pyne, Emmery Hammond, and Michel Bouvier

Subjects
Biology (General), QH301-705.5
Abstract

Abstract Classically, G protein-coupled receptors (GPCRs) promote signaling at the plasma membrane through activation of heterotrimeric Gαβγ proteins, followed by the recruitment of GPCR kinases and βarrestin (βarr) to initiate receptor desensitization and internalization. However, studies demonstrated that some GPCRs continue to signal from internalized compartments, with distinct cellular responses. Both βarr and Gβγ contribute to such non-canonical endosomal G protein signaling, but their specific roles and contributions remain poorly understood. Here, we demonstrate that the vasopressin V2 receptor (V2R)–βarr complex scaffolds Gβγ at the plasma membrane through a direct interaction with βarr, enabling its transport to endosomes. Gβγ subsequently potentiates Gαs endosomal translocation, presumably to regenerate an endosomal pool of heterotrimeric Gs. This work shines light on the mechanism underlying G protein subunits translocation from the plasma membrane to the endosomes and provides a basis for understanding the role of βarr in mediating sustained G protein signaling.

Published
2024
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4. The Warburg effect alters amino acid homeostasis in human retinal endothelial cells: implication for proliferative diabetic retinopathy

Author

Andrew Gregory, Thangal Yumnamcha, Mohamed Shawky, Shaimaa Eltanani, Armaan Naghdi, Bing X. Ross, Xihui Lin, and Ahmed S. Ibrahim

Subjects
Medicine, Science
Abstract

Abstract Proliferative diabetic retinopathy (PDR) remains a leading cause of blindness despite progress in screening and treatment. Recently, the Warburg effect, a metabolic alteration affecting amino acid (AA) metabolism in proliferating cells, has drawn attention regarding its role in PDR. This study aimed to investigate the impact of the Warburg effect on AA metabolism in human retinal endothelial cells (HRECs) subjected to PDR-associated risk factors and validate the findings in patients with PDR. In vitro experiments exposed HRECs to high glucose (HG) and/or hypoxia (Hyp), known inducers of the Warburg effect. The HG + Hyp group of HRECs exhibited significant differences in non-essential AAs with aliphatic non-polar side chains, mainly driven by elevated glycine concentrations. Pathway enrichment analysis revealed several glycine metabolism-related pathways significantly altered due to the Warburg effect induced by HG + Hyp. Crucially, vitreous humor samples from PDR patients displayed higher glycine levels compared to non-diabetic and diabetic patients without PDR. The odds ratio for PDR patients with glycine levels above the cut-off of 0.0836 µM was 28 (p = 0.03) compared to non-PDR controls. In conclusion, this study provides mechanistic insights into how a specific Warburg effect subtype contributes to glycine accumulation in PDR and supports glycine's potential as a biomarker for PDR pathogenesis.

Published
2023
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5. Patient Clinical Outcomes in Standalone Versus a Combined Ophthalmology-rheumatology Uveitis Clinic

Author

Bing X. Ross, Samantha Habhab, Sarah Syeda, Ahmad Baiyasi, Ilyes Benchaala, Chinwenwa Okeagu, Joshua Barbosa, Jacob Im, Kim Le, and Xihui Lin

Subjects
Uveitis, Combined clinic, Rheumatology, Steroid sparing therapy, Immunomodulatory therapy, Ophthalmology, RE1-994
Abstract

Abstract Background To evaluate uveitis care outcomes in standalone versus a combined ophthalmology-rheumatology clinic. Methods Participants were patients aged 18 years and older with a minimum 12-month history of chronic uveitis prior to being referred to the combined uveitis clinic at Kresge Eye Institute and who were treated in the combined clinic for at least 6 months. Best corrected visual acuity (BCVA), objective markers of inflammation, and achieving targeted dose of immunomodulatory therapy (IMT) were compared in the cohort of uveitis patients 6 months prior to and after the initial evaluation in the combined clinic. Results Sixty-six percent of study participants were female with a mean age of 51.5 years. BCVA improved from 0.58 logMAR (Snellen: ~20/74) at the initial combined clinic visit to 0.50 logMAR (Snellen: ~20/63) 6 months after the first combined visit (p = 0.0137). The establishment of the combined uveitis clinic led to higher frequency of patients at target dose of IMT: an increase from 49.0% at 6 months prior to the combined visit to 70.1.4% and 79.8% at the initial combined visit and 6 months after the combined visit, respectively. Conclusion A combined model of management for chronic uveitis patients wherein rheumatological services are coupled with ophthalmic care leads to improvement in patient clinical outcomes and achieving target therapy.

Published
2022
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6. An Ophthalmology Virtual Externship during the COVID-19 Pandemic: A Pilot Study

Author

Karim Dirani, Jahan Tajran, Komalpreet Tur, Annmarie Craig, Ryan L. Freedman, Niyaz Uddin, Chaesik Kim, Bing X. Ross, Mark S. Juzych, and Anju Goyal

Subjects
virtual externship, ophthalmology, confidence, mentorship, Ophthalmology, RE1-994
Abstract

Background The evolution of medical school curricula, characterized by truncated preclinical periods and reduced emphasis on ophthalmology, presents formidable obstacles to early exposure for aspiring medical students. The constraints imposed by the coronavirus disease 2019 pandemic further exacerbated the limitations on opportunities, compelling the implementation of innovative initiatives aimed at augmenting students' ophthalmology education through virtual means.

Published
2023
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8. Tfh Exosomes Derived from Allergic Rhinitis Promote DC Maturation Through miR-142-5p/CDK5/STAT3 Pathway

Author

Teng ZX, Zhou XC, Xu RT, Zhu FY, Bing X, Guo N, Shi L, Qi WW, Liu CC, and Xia M

Subjects
allergic rhinitis, tfhs, exosome, dendritic cells, mir-142-5p, cdk5, stat3, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract

Zhen-Xiao Teng,1,* Xuan-Chen Zhou,2,* Run-Tong Xu,2 Fang-Yuan Zhu,2 Xin Bing,1 Na Guo,2 Lei Shi,2 Wen-Wen Qi,1 Cheng-Cheng Liu,3 Ming Xia1,2 1Department of Otolaryngology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China; 2Department of Otolaryngology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, People’s Republic of China; 3Central Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ming Xia, Department of Otolaryngology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China, 250012, Tel +86-68779106, Email xiamingsdu@sohu.com Cheng-Cheng Liu, Department of Otolaryngology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250000, People’s Republic of China, Tel +86-68776913, Email Lccheng211314@126.comBackground: Dendritic cells (DCs) play an important role in allergen signal presentation. Many studies showed that follicular helper T cells (Tfhs) are related to allergic rhinitis (AR). However, the relationship between Tfhs and DCs and the mechanism of their interaction with AR remain unclear.Purpose: To explore the mechanism of Tfhs on DC maturation in AR.Methods: Tfhs were isolated from OVA-sensitized mice and co-cultured with DCs derived from mouse bone marrow. DCs maturity was monitored using flow cytometry and immunofluorescence staining. Exosomes of Tfhs were extracted, and miRNAs inside exosomes were analyzed using RNA-seq to identify differentially expressed genes. Using the TargetScan algorithm, it was predicted that CDK5 is a direct target gene, which is validated in a dual luciferase assay. DCs were treated with miR-142-5p mimics or inhibitors or transfected with CDK5 small interfering RNAs to verify the regulatory effects of miR-142-5p and CDK5 on DC maturation. How CDK5 regulates STAT3 signaling pathway was investigated to elucidate the molecular mechanism of DC maturation. Finally, in an in vivo experiment, the exosomes of AR-derived Tfhs were injected intravenously to detect their promotion of AR.Results: Tfh exosomes derived from AR mice contributed to DC maturation. RNA-seq results showed that miR-142-5p was the differentially decreased gene. Using the TargetScan algorithm, it was predicted that CDK5 was the target gene for the direct action of miR-142-5p. By detecting the effects of changes in the expression levels of miR-142-5p and CDK5 on DC maturation, it was demonstrated that miR-142-5p inhibits DC maturation by inhibiting CDK5 expression. CDK5-regulated STAT3 signaling pathway during DC maturation, and inhibition of the STAT3 signaling pathway can reverse the regulation of miR-142-5p/CDK5 on DC maturation. Finally, in vivo experiment indicated that the injection of AR-derived Tfhs promoted AR in mice.Conclusion: Tfh-derived exosomes induce DC maturation by regulating miR-142-5p/CDK5/STAT3 signaling pathway, thereby promoting the occurrence of AR.Keywords: allergic rhinitis, Tfhs, exosome, dendritic cells, miR-142-5p, CDK5, STAT3

Published
2022

11. Accuracy of intravitreal injection volume for aflibercept pre-filled syringe and BD Luer-Lok one-milliliter syringe

Author

John-Michael Guest, Brett Malbin, Gary Abrams, Anthony Parendo, Shibandri Das, Chinwenwa Okeagu, Bing X. Ross, Ashok Kumar, and Xihui Lin

Subjects
Aflibercept, Intravitreal injection, Pre-filled syringe, Ophthalmology, RE1-994
Abstract

Abstract Background To evaluate the accuracy of intravitreal injection volume of the pre-filled syringe (PFS) in which aflibercept is packaged compared to the BD Luer-Lok 1-mL syringe. Methods Ophthalmologists injected their typical intravitreal volume for aflibercept using either the PFS or BD Luer-Lok 1-mL syringe for 5 times each. The injected fluid was weighed using a micro-scale and converted to volume. The volume of fluid injected was also evaluated when the 0.05 mL line on the PFS was lined up to the tip or base of the dome-shaped plunger. Results Injection volume was measured for 12 physicians. The average injected fluid volume was 74.22 ± 15.87 µL for PFS and 53.42 ± 4.61 µL for the BD Luer-Lok 1-mL syringe (p

Published
2022
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13. Beam-energy and system-size dependence of the space-time extent of the pion emission source produced in heavy ion collisions

Author

Adare, A., Afanasiev, S., Aidala, C., Ajitanand, N. N., Akiba, Y., Akimoto, R., Al-Bataineh, H., Al-Ta'ani, H., Alexander, J., Alfred, M., Angerami, A., Aoki, K., Apadula, N., Aphecetche, L., Aramaki, Y., Armendariz, R., Aronson, S. H., Asai, J., Asano, H., Aschenauer, E. C., Atomssa, E. T., Averbeck, R., Awes, T. C., Azmoun, B., Babintsev, V., Bai, M., Baksay, G., Baksay, L., Baldisseri, A., Bandara, N. S., Bannier, B., Barish, K. N., Barnes, P. D., Bassalleck, B., Basye, A. T., Bathe, S., Batsouli, S., Baublis, V., Baumann, C., Baumgart, S., Bazilevsky, A., Beaumier, M., Beckman, S., Belikov, S., Belmont, R., Bennett, R., Berdnikov, A., Berdnikov, Y., Bickley, A. A., Bing, X., Black, D., Blau, D. S., Boissevain, J. G., Bok, J. S., Borel, H., Boyle, K., Brooks, M. L., Bryslawskyj, J., Buesching, H., Bumazhnov, V., Bunce, G., Butsyk, S., Camacho, C. M., Campbell, S., Castera, P., Chang, B. S., Charvet, J. -L., Chen, C. -H., Chernichenko, S., Chi, C. Y., Chiba, J., Chiu, M., Choi, I. J., Choi, J. B., Choi, S., Choudhury, R. K., Christiansen, P., Chujo, T., Chung, P., Churyn, A., Chvala, O., Cianciolo, V., Citron, Z., Cleven, C. R., Cole, B. A., Comets, M. P., Connors, M., Constantin, P., Csanád, M., Csörgő, T., Dahms, T., Dairaku, S., Danchev, I., Das, K., Datta, A., Daugherity, M. S., David, G., Deaton, M. B., DeBlasio, K., Dehmelt, K., Delagrange, H., Denisov, A., d'Enterria, D., Deshpande, A., Desmond, E. J., Dharmawardane, K. V., Dietzsch, O., Ding, L., Dion, A., Do, J. H., Donadelli, M., Drapier, O., Drees, A., Drees, K. A., Dubey, A. K., Durham, J. M., Durum, A., Dutta, D., Dzhordzhadze, V., D'Orazio, L., Edwards, S., Efremenko, Y. V., Egdemir, J., Ellinghaus, F., Emam, W. S., Engelmore, T., Enokizono, A., En'yo, H., Esumi, S., Eyser, K. O., Fadem, B., Feege, N., Fields, D. E., Finger, M., Finger, Jr., M., Fleuret, F., Fokin, S. L., Fraenkel, Z., Frantz, J. E., Franz, A., Frawley, A. D., Fujiwara, K., Fukao, Y., Fusayasu, T., Gadrat, S., Gainey, K., Gal, C., Gallus, P., Garg, P., Garishvili, A., Garishvili, I., Ge, H., Giordano, F., Glenn, A., Gong, H., Gong, X., Gonin, M., Gosset, J., Goto, Y., de Cassagnac, R. Granier, Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gu, Y., Gunji, T., Guo, L., Guragain, H., Gustafsson, H. -Å., Hachiya, T., Henni, A. Hadj, Haegemann, C., Haggerty, J. S., Hahn, K. I., Hamagaki, H., Hamblen, J., Han, R., Han, S. Y., Hanks, J., Harada, H., Hartouni, E. P., Haruna, K., Hasegawa, S., Hashimoto, K., Haslum, E., Hayano, R., He, X., Heffner, M., Hemmick, T. K., Hester, T., Hiejima, H., Hill, J. C., Hobbs, R., Hohlmann, M., Hollis, R. S., Holzmann, W., Homma, K., Hong, B., Horaguchi, T., Hori, Y., Hornback, D., Hoshino, T., Huang, J., Huang, S., Ichihara, T., Ichimiya, R., Ide, J., Iinuma, H., Ikeda, Y., Imai, K., Imazu, Y., Imrek, J., Inaba, M., Inoue, Y., Iordanova, A., Isenhower, D., Isenhower, L., Ishihara, M., Isobe, T., Issah, M., Isupov, A., Ivanischev, D., Ivanishchev, D., Jacak, B. V., Javani, M., Jeon, S. J., Jezghani, M., Jia, J., Jiang, X., Jin, J., Jinnouchi, O., Johnson, B. M., Joo, E., Joo, K. S., Jouan, D., Jumper, D. S., Kajihara, F., Kametani, S., Kamihara, N., Kamin, J., Kaneta, M., Kaneti, S., Kang, B. H., Kang, J. H., Kang, J. S., Kanou, H., Kapustinsky, J., Karatsu, K., Kasai, M., Kawall, D., Kawashima, M., Kazantsev, A. V., Kempel, T., Key, J. A., Khachatryan, V., Khanzadeev, A., Kihara, K., Kijima, K. M., Kikuchi, J., Kim, B. I., Kim, C., Kim, D. H., Kim, D. J., Kim, E., Kim, E. -J., Kim, H. -J., Kim, H. J., Kim, K. -B., Kim, M., Kim, S. H., Kim, Y. -J., Kim, Y. K., Kinney, E., Kiriluk, K., Kiss, Á., Kistenev, E., Kiyomichi, A., Klatsky, J., Klay, J., Klein-Boesing, C., Kleinjan, D., Kline, P., Koblesky, T., Kochenda, L., Kochetkov, V., Kofarago, M., Komatsu, Y., Komkov, B., Konno, M., Koster, J., Kotchetkov, D., Kotov, D., Kozlov, A., Král, A., Kravitz, A., Krizek, F., Kubart, J., Kunde, G. J., Kurihara, N., Kurita, K., Kurosawa, M., Kweon, M. J., Kwon, Y., Kyle, G. S., Lacey, R., Lai, Y. S., Lajoie, J. G., Lebedev, A., Lee, B., Lee, D. M., Lee, J., Lee, K., Lee, K. B., Lee, K. S., Lee, M. K., Lee, S. H., Lee, S. R., Lee, T., Leitch, M. J., Leite, M. A. L., Leitgab, M., Leitner, E., Lenzi, B., Lewis, B., Li, X., Liebing, P., Lim, S. H., Levy, L. A. Linden, Liška, T., Litvinenko, A., Liu, H., Liu, M. X., Love, B., Luechtenborg, R., Lynch, D., Maguire, C. F., Makdisi, Y. I., Makek, M., Malakhov, A., Malik, M. D., Manion, A., Manko, V. I., Mannel, E., Mao, Y., Mašek, L., Masui, H., Masumoto, S., Matathias, F., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Means, N., Meles, A., Mendoza, M., Meredith, B., Miake, Y., Mibe, T., Mignerey, A. C., Mikeš, P., Miki, K., Miller, A. J., Miller, T. E., Milov, A., Mioduszewski, S., Mishra, D. K., Mishra, M., Mitchell, J. T., Mitrovski, M., Miyachi, Y., Miyasaka, S., Mizuno, S., Mohanty, A. K., Montuenga, P., Moon, H. J., Moon, T., Morino, Y., Morreale, A., Morrison, D. P., Motschwiller, S., Moukhanova, T. V., Mukhopadhyay, D., Murakami, T., Murata, J., Mwai, A., Nagae, T., Nagamiya, S., Nagata, Y., Nagle, J. L., Naglis, M., Nagy, M. I., Nakagawa, I., Nakagomi, H., Nakamiya, Y., Nakamura, K. R., Nakamura, T., Nakano, K., Nattrass, C., Nederlof, A., Netrakanti, P. K., Newby, J., Nguyen, M., Nihashi, M., Niida, T., Norman, B. E., Nouicer, R., Novitzky, N., Nyanin, A. S., O'Brien, E., Oda, S. X., Ogilvie, C. A., Ohnishi, H., Oka, M., Okada, K., Omiwade, O. O., Onuki, Y., Koop, J. D. Orjuela, Oskarsson, A., Ouchida, M., Ozaki, H., Ozawa, K., Pak, R., Pal, D., Palounek, A. P. T., Pantuev, V., Papavassiliou, V., Park, B. H., Park, I. H., Park, J., Park, S., Park, S. K., Park, W. J., Pate, S. F., Patel, L., Patel, M., Pei, H., Peng, J. -C., Pereira, H., Perepelitsa, D. V., Perera, G. D. N., Peresedov, V., Peressounko, D. Yu., Perry, J., Petti, R., Pinkenburg, C., Pinson, R., Pisani, R. P., Proissl, M., Purschke, M. L., Purwar, A. K., Qu, H., Rak, J., Rakotozafindrabe, A., Ravinovich, I., Read, K. F., Rembeczki, S., Reuter, M., Reygers, K., Reynolds, D., Riabov, V., Riabov, Y., Richardson, E., Riveli, N., Roach, D., Roche, G., Rolnick, S. D., Romana, A., Rosati, M., Rosen, C. A., Rosendahl, S. S. E., Rosnet, P., Rowan, Z., Rubin, J. G., Rukoyatkin, P., Ružička, P., Rykov, V. L., Sahlmueller, B., Saito, N., Sakaguchi, T., Sakai, S., Sakashita, K., Sakata, H., Sako, H., Samsonov, V., Sano, M., Sano, S., Sarsour, M., Sato, S., Sato, T., Sawada, S., Schaefer, B., Schmoll, B. K., Sedgwick, K., Seele, J., Seidl, R., Semenov, A. Yu., Semenov, V., Sen, A., Seto, R., Sett, P., Sexton, A., Sharma, D., Shein, I., Shevel, A., Shibata, T. -A., Shigaki, K., Shimomura, M., Shoji, K., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Silvestre, C., Sim, K. S., Singh, B. K., Singh, C. P., Singh, V., Skutnik, S., Slunečka, M., Soldatov, A., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Soumya, M., Sourikova, I. V., Sparks, N. A., Staley, F., Stankus, P. W., Stenlund, E., Stepanov, M., Ster, A., Stoll, S. P., Sugitate, T., Suire, C., Sukhanov, A., Sumita, T., Sun, J., Sziklai, J., Tabaru, T., Takagi, S., Takagui, E. M., Takahara, A., Taketani, A., Tanabe, R., Tanaka, Y., Taneja, S., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tarján, P., Tennant, E., Themann, H., Thomas, T. L., Timilsina, A., Todoroki, T., Togawa, M., Toia, A., Tojo, J., Tomášek, L., Tomášek, M., Torii, H., Towell, M., Towell, R., Towell, R. S., Tram, V-N., Tserruya, I., Tsuchimoto, Y., Tsuji, T., Vale, C., Valle, H., van Hecke, H. W., Vargyas, M., Vazquez-Zambrano, E., Veicht, A., Velkovska, J., Vértesi, R., Vinogradov, A. A., Virius, M., Vossen, A., Vrba, V., Vznuzdaev, E., Wagner, M., Walker, D., Wang, X. R., Watanabe, D., Watanabe, K., Watanabe, Y., Watanabe, Y. S., Wei, F., Wei, R., Wessels, J., Whitaker, S., White, S. N., Winter, D., Wolin, S., Wood, J. P., Woody, C. L., Wright, R. M., Wysocki, M., Xia, B., Xie, W., Xue, L., Yalcin, S., Yamaguchi, Y. L., Yamaura, K., Yang, R., Yanovich, A., Yasin, Z., Ying, J., Yokkaichi, S., Yoon, I., You, Z., Young, G. R., Younus, I., Yushmanov, I. E., Zajc, W. A., Zaudtke, O., Zelenski, A., Zhang, C., Zhou, S., Zimányi, J., and Zolin, L.

Subjects
Nuclear Experiment
Abstract

Two-pion interferometry measurements are used to extract the Gaussian radii $R_{{\rm out}}$, $R_{{\rm side}}$, and $R_{{\rm long}}$, of the pion emission sources produced in Cu$+$Cu and Au$+$Au collisions at several beam collision energies $\sqrt{s_{_{NN}}}$ at PHENIX. The extracted radii, which are compared to recent STAR and ALICE data, show characteristic scaling patterns as a function of the initial transverse size $\bar{R}$ of the collision systems and the transverse mass $m_T$ of the emitted pion pairs, consistent with hydrodynamiclike expansion. Specific combinations of the three-dimensional radii that are sensitive to the medium expansion velocity and lifetime, and the pion emission time duration show nonmonotonic $\sqrt{s_{_{NN}}}$ dependencies. The nonmonotonic behaviors exhibited by these quantities point to a softening of the equation of state that may coincide with the critical end point in the phase diagram for nuclear matter., Comment: 622 authors, 8 pages, 5 figures, data from 2005, 2007, and 2010. Submitted to Phys. Rev. Lett. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.html

Published
2014

14. Centrality dependence of low-momentum direct-photon production in Au$+$Au collisions at $\sqrt{s_{_{NN}}}=200$ GeV

Author

Adare, A., Afanasiev, S., Aidala, C., Ajitanand, N. N., Akiba, Y., Akimoto, R., Al-Bataineh, H., Al-Ta'ani, H., Alexander, J., Angerami, A., Aoki, K., Apadula, N., Aramaki, Y., Asano, H., Aschenauer, E. C., Atomssa, E. T., Averbeck, R., Awes, T. C., Azmoun, B., Babintsev, V., Bai, M., Baksay, G., Baksay, L., Bannier, B., Barish, K. N., Bassalleck, B., Basye, A. T., Bathe, S., Baublis, V., Baumann, C., Baumgart, S., Bazilevsky, A., Belikov, S., Belmont, R., Bennett, R., Berdnikov, A., Berdnikov, Y., Bickley, A. A., Bing, X., Blau, D. S., Bok, J. S., Boyle, K., Brooks, M. L., Buesching, H., Bumazhnov, V., Bunce, G., Butsyk, S., Camacho, C. M., Campbell, S., Castera, P., Chen, C. -H., Chi, C. Y., Chiu, M., Choi, I. J., Choi, J. B., Choi, S., Choudhury, R. K., Christiansen, P., Chujo, T., Chung, P., Chvala, O., Cianciolo, V., Citron, Z., Cole, B. A., Connors, M., Constantin, P., Csanád, M., Csörgő, T., Dahms, T., Dairaku, S., Danchev, I., Das, K., Datta, A., Daugherity, M. S., David, G., Denisov, A., Deshpande, A., Desmond, E. J., Dharmawardane, K. V., Dietzsch, O., Ding, L., Dion, A., Donadelli, M., Drapier, O., Drees, A., Drees, K. A., Durham, J. M., Durum, A., Dutta, D., D'Orazio, L., Edwards, S., Efremenko, Y. V., Ellinghaus, F., Engelmore, T., Enokizono, A., En'yo, H., Esumi, S., Eyser, K. O., Fadem, B., Fields, D. E., Finger, M., Finger, Jr., M., Fleuret, F., Fokin, S. L., Fraenkel, Z., Frantz, J. E., Franz, A., Frawley, A. D., Fujiwara, K., Fukao, Y., Fusayasu, T., Gainey, K., Gal, C., Garishvili, A., Garishvili, I., Glenn, A., Gong, H., Gong, X., Gonin, M., Goto, Y., de Cassagnac, R. Granier, Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gunji, T., Guo, L., Gustafsson, H. -Å., Hachiya, T., Haggerty, J. S., Hahn, K. I., Hamagaki, H., Hamblen, J., Han, R., Hanks, J., Hartouni, E. P., Hashimoto, K., Haslum, E., Hayano, R., He, X., Heffner, M., Hemmick, T. K., Hester, T., Hill, J. C., Hohlmann, M., Hollis, R. S., Holzmann, W., Homma, K., Hong, B., Horaguchi, T., Hori, Y., Hornback, D., Huang, S., Ichihara, T., Ichimiya, R., Ide, J., Iinuma, H., Ikeda, Y., Imai, K., Imrek, J., Inaba, M., Iordanova, A., Isenhower, D., Ishihara, M., Isobe, T., Issah, M., Isupov, A., Ivanischev, D., Ivanishchev, D., Jacak, B. V., Javani, M., Jia, J., Jiang, X., Jin, J., Johnson, B. M., Joo, K. S., Jouan, D., Jumper, D. S., Kajihara, F., Kametani, S., Kamihara, N., Kamin, J., Kaneti, S., Kang, B. H., Kang, J. H., Kang, J. S., Kapustinsky, J., Karatsu, K., Kasai, M., Kawall, D., Kawashima, M., Kazantsev, A. V., Kempel, T., Khanzadeev, A., Kijima, K. M., Kim, B. I., Kim, C., Kim, D. H., Kim, D. J., Kim, E., Kim, E. -J., Kim, H. J., Kim, K. -B., Kim, S. H., Kim, Y. -J., Kim, Y. K., Kinney, E., Kiriluk, K., Kiss, Á., Kistenev, E., Klatsky, J., Kleinjan, D., Kline, P., Kochenda, L., Komatsu, Y., Komkov, B., Konno, M., Koster, J., Kotchetkov, D., Kotov, D., Kozlov, A., Král, A., Kravitz, A., Krizek, F., Kunde, G. J., Kurita, K., Kurosawa, M., Kwon, Y., Kyle, G. S., Lacey, R., Lai, Y. S., Lajoie, J. G., Lebedev, A., Lee, B., Lee, D. M., Lee, J., Lee, K., Lee, K. B., Lee, K. S., Lee, S. H., Lee, S. R., Leitch, M. J., Leite, M. A. L., Leitgab, M., Leitner, E., Lenzi, B., Lewis, B., Li, X., Liebing, P., Lim, S. H., Levy, L. A. Linden, Liška, T., Litvinenko, A., Liu, H., Liu, M. X., Love, B., Luechtenborg, R., Lynch, D., Maguire, C. F., Makdisi, Y. I., Makek, M., Malakhov, A., Malik, M. D., Manion, A., Manko, V. I., Mannel, E., Mao, Y., Masui, H., Masumoto, S., Matathias, F., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Means, N., Mendoza, M., Meredith, B., Miake, Y., Mibe, T., Mignerey, A. C., Mikeš, P., Miki, K., Milov, A., Mishra, D. K., Mishra, M., Mitchell, J. T., Miyachi, Y., Miyasaka, S., Mohanty, A. K., Moon, H. J., Morino, Y., Morreale, A., Morrison, D. P., Motschwiller, S., Moukhanova, T. V., Murakami, T., Murata, J., Nagae, T., Nagamiya, S., Nagle, J. L., Naglis, M., Nagy, M. I., Nakagawa, I., Nakamiya, Y., Nakamura, K. R., Nakamura, T., Nakano, K., Nattrass, C., Nederlof, A., Newby, J., Nguyen, M., Nihashi, M., Nouicer, R., Novitzky, N., Nyanin, A. S., O'Brien, E., Oda, S. X., Ogilvie, C. A., Oka, M., Okada, K., Onuki, Y., Oskarsson, A., Ouchida, M., Ozawa, K., Pak, R., Pantuev, V., Papavassiliou, V., Park, B. H., Park, I. H., Park, J., Park, S. K., Park, W. J., Pate, S. F., Patel, L., Pei, H., Peng, J. -C., Pereira, H., Peresedov, V., Peressounko, D. Yu., Petti, R., Pinkenburg, C., Pisani, R. P., Proissl, M., Purschke, M. L., Purwar, A. K., Qu, H., Rak, J., Rakotozafindrabe, A., Ravinovich, I., Read, K. F., Reygers, K., Reynolds, D., Riabov, V., Riabov, Y., Richardson, E., Riveli, N., Roach, D., Roche, G., Rolnick, S. D., Rosati, M., Rosen, C. A., Rosendahl, S. S. E., Rosnet, P., Rukoyatkin, P., Ružička, P., Sahlmueller, B., Saito, N., Sakaguchi, T., Sakashita, K., Samsonov, V., Sano, M., Sano, S., Sarsour, M., Sato, T., Sawada, S., Sedgwick, K., Seele, J., Seidl, R., Semenov, A. Yu., Sen, A., Seto, R., Sharma, D., Shein, I., Shibata, T. -A., Shigaki, K., Shimomura, M., Shoji, K., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Silvestre, C., Sim, K. S., Singh, B. K., Singh, C. P., Singh, V., Slunečka, M., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Soumya, M., Sourikova, I. V., Sparks, N. A., Stankus, P. W., Stenlund, E., Stepanov, M., Ster, A., Stoll, S. P., Sugitate, T., Sukhanov, A., Sun, J., Sziklai, J., Takagui, E. M., Takahara, A., Taketani, A., Tanabe, R., Tanaka, Y., Taneja, S., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tarján, P., Tennant, E., Themann, H., Thomas, T. L., Todoroki, T., Togawa, M., Toia, A., Tomášek, L., Tomášek, M., Torii, H., Towell, R. S., Tserruya, I., Tsuchimoto, Y., Tsuji, T., Vale, C., Valle, H., van Hecke, H. W., Vargyas, M., Vazquez-Zambrano, E., Veicht, A., Velkovska, J., Vértesi, R., Vinogradov, A. A., Virius, M., Vossen, A., Vrba, V., Vznuzdaev, E., Wang, X. R., Watanabe, D., Watanabe, K., Watanabe, Y., Watanabe, Y. S., Wei, F., Wei, R., Wessels, J., Whitaker, S., White, S. N., Winter, D., Wolin, S., Wood, J. P., Woody, C. L., Wright, R. M., Wysocki, M., Xie, W., Yamaguchi, Y. L., Yamaura, K., Yang, R., Yanovich, A., Ying, J., Yokkaichi, S., You, Z., Young, G. R., Younus, I., Yushmanov, I. E., Zajc, W. A., Zelenski, A., Zhang, C., Zhou, S., and Zolin, L.

Subjects
Nuclear Experiment
Abstract

The PHENIX experiment at RHIC has measured the centrality dependence of the direct photon yield from Au$+$Au collisions at $\sqrt{s_{_{NN}}}=200$ GeV down to $p_T=0.4$ GeV/$c$. Photons are detected via photon conversions to $e^+e^-$ pairs and an improved technique is applied that minimizes the systematic uncertainties that usually limit direct photon measurements, in particular at low $p_T$. We find an excess of direct photons above the $N_{\rm coll}$-scaled yield measured in $p$$+$$p$ collisions. This excess yield is well described by an exponential distribution with an inverse slope of about 240 MeV/$c$ in the $p_T$ range from 0.6--2.0 GeV/$c$. While the shape of the $p_T$ distribution is independent of centrality within the experimental uncertainties, the yield increases rapidly with increasing centrality, scaling approximately with $N_{\rm part}^\alpha$, where $\alpha=1.48{\pm}0.08({\rm stat}){\pm}0.04({\rm syst})$., Comment: 480 authors, pages, 9 figures, 3 tables, 2007 and 2010 data. Submitted to Phys. Rev. C. v2 is version accepted by PRC w/ updated figures. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are publicly available at http://www.phenix.bnl.gov/papers.html

Published
2014

15. Heavy-quark production and elliptic flow in Au$+$Au collisions at $\sqrt{s_{_{NN}}}=62.4$ GeV

Author

Adare, A., Aidala, C., Ajitanand, N. N., Akiba, Y., Akimoto, R., Al-Ta'ani, H., Alexander, J., Angerami, A., Aoki, K., Apadula, N., Aramaki, Y., Asano, H., Aschenauer, E. C., Atomssa, E. T., Awes, T. C., Azmoun, B., Babintsev, V., Bai, M., Bannier, B., Barish, K. N., Bassalleck, B., Bathe, S., Baublis, V., Baumgart, S., Bazilevsky, A., Belmont, R., Berdnikov, A., Berdnikov, Y., Bing, X., Blau, D. S., Bok, J. S., Boyle, K., Brooks, M. L., Buesching, H., Bumazhnov, V., Butsyk, S., Campbell, S., Castera, P., Chen, C. -H., Chi, C. Y., Chiu, M., Choi, I. J., Choi, J. B., Choi, S., Choudhury, R. K., Christiansen, P., Chujo, T., Chvala, O., Cianciolo, V., Citron, Z., Cole, B. A., Connors, M., Csanád, M., Csörgő, T., Dairaku, S., Datta, A., Daugherity, M. S., David, G., Denisov, A., Deshpande, A., Desmond, E. J., Dharmawardane, K. V., Dietzsch, O., Ding, L., Dion, A., Donadelli, M., Drapier, O., Drees, A., Drees, K. A., Durham, J. M., Durum, A., D'Orazio, L., Edwards, S., Efremenko, Y. V., Engelmore, T., Enokizono, A., Esumi, S., Eyser, K. O., Fadem, B., Fields, D. E., Finger, M., Finger, Jr., M., Fleuret, F., Fokin, S. L., Frantz, J. E., Franz, A., Frawley, A. D., Fukao, Y., Fusayasu, T., Gainey, K., Gal, C., Garishvili, A., Garishvili, I., Glenn, A., Gong, X., Gonin, M., Goto, Y., de Cassagnac, R. Granier, Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gunji, T., Guo, L., Gustafsson, H. -Å., Hachiya, T., Haggerty, J. S., Hahn, K. I., Hamagaki, H., Hanks, J., Hashimoto, K., Haslum, E., Hayano, R., He, X., Hemmick, T. K., Hester, T., Hill, J. C., Hollis, R. S., Homma, K., Hong, B., Horaguchi, T., Hori, Y., Huang, S., Ichihara, T., Iinuma, H., Ikeda, Y., Imrek, J., Inaba, M., Iordanova, A., Isenhower, D., Issah, M., Ivanishchev, D., Jacak, B. V., Javani, M., Jia, J., Jiang, X., Johnson, B. M., Joo, K. S., Jouan, D., Jumper, D. S., Kamin, J., Kaneti, S., Kang, B. H., Kang, J. H., Kang, J. S., Kapustinsky, J., Karatsu, K., Kasai, M., Kawall, D., Kazantsev, A. V., Kempel, T., Khanzadeev, A., Kijima, K. M., Kim, B. I., Kim, C., Kim, D. J., Kim, E. -J., Kim, H. J., Kim, K. -B., Kim, Y. -J., Kim, Y. K., Kinney, E., Kiss, Á., Kistenev, E., Klatsky, J., Kleinjan, D., Kline, P., Komatsu, Y., Komkov, B., Koster, J., Kotchetkov, D., Kotov, D., Král, A., Krizek, F., Kunde, G. J., Kurita, K., Kurosawa, M., Kwon, Y., Kyle, G. S., Lacey, R., Lai, Y. S., Lajoie, J. G., Lebedev, A., Lee, B., Lee, D. M., Lee, J., Lee, K. B., Lee, K. S., Lee, S. H., Lee, S. R., Leitch, M. J., Leite, M. A. L., Leitgab, M., Lewis, B., Lim, S. H., Levy, L. A. Linden, Liu, M. X., Love, B., Maguire, C. F., Makdisi, Y. I., Makek, M., Manion, A., Manko, V. I., Mannel, E., Masumoto, S., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Mendoza, M., Meredith, B., Miake, Y., Mibe, T., Mignerey, A. C., Milov, A., Mishra, D. K., Mitchell, J. T., Miyachi, Y., Miyasaka, S., Mohanty, A. K., Moon, H. J., Morrison, D. P., Motschwiller, S., Moukhanova, T. V., Murakami, T., Murata, J., Nagae, T., Nagamiya, S., Nagle, J. L., Nagy, M. I., Nakagawa, I., Nakamiya, Y., Nakamura, K. R., Nakamura, T., Nakano, K., Nattrass, C., Nederlof, A., Nihashi, M., Nouicer, R., Novitzky, N., Nyanin, A. S., O'Brien, E., Ogilvie, C. A., Okada, K., Oskarsson, A., Ouchida, M., Ozawa, K., Pak, R., Pantuev, V., Papavassiliou, V., Park, B. H., Park, I. H., Park, S. K., Pate, S. F., Patel, L., Pei, H., Peng, J. -C., Pereira, H., Peressounko, D. Yu., Petti, R., Pinkenburg, C., Pisani, R. P., Proissl, M., Purschke, M. L., Qu, H., Rak, J., Ravinovich, I., Read, K. F., Reynolds, D., Riabov, V., Riabov, Y., Richardson, E., Riveli, N., Roach, D., Roche, G., Rolnick, S. D., Rosati, M., Sahlmueller, B., Saito, N., Sakaguchi, T., Samsonov, V., Sano, M., Sarsour, M., Sawada, S., Sedgwick, K., Seidl, R., Sen, A., Seto, R., Sharma, D., Shein, I., Shibata, T. -A., Shigaki, K., Shimomura, M., Shoji, K., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Sim, K. S., Singh, B. K., Singh, C. P., Singh, V., Slunečka, M., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Soumya, M., Sourikova, I. V., Stankus, P. W., Stenlund, E., Stepanov, M., Ster, A., Stoll, S. P., Sugitate, T., Sukhanov, A., Sun, J., Sziklai, J., Takagui, E. M., Takahara, A., Taketani, A., Tanaka, Y., Taneja, S., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tennant, E., Themann, H., Todoroki, T., Tomášek, L., Tomášek, M., Torii, H., Towell, R. S., Tserruya, I., Tsuchimoto, Y., Tsuji, T., Vale, C., van Hecke, H. W., Vargyas, M., Vazquez-Zambrano, E., Veicht, A., Velkovska, J., Vértesi, R., Virius, M., Vossen, A., Vrba, V., Vznuzdaev, E., Wang, X. R., Watanabe, D., Watanabe, K., Watanabe, Y., Watanabe, Y. S., Wei, F., Wei, R., Whitaker, S., White, S. N., Winter, D., Wolin, S., Woody, C. L., Wysocki, M., Yamaguchi, Y. L., Yang, R., Yanovich, A., Ying, J., Yokkaichi, S., You, Z., Younus, I., Yushmanov, I. E., Zajc, W. A., and Zelenski, A.

Subjects
Nuclear Experiment
Abstract

We present measurements of electrons and positrons from the semileptonic decays of heavy-flavor hadrons at midrapidity ($|y|<$ 0.35) in Au$+$Au collisions at $\sqrt{s_{_{NN}}}=62.4$ GeV. The data were collected in 2010 by the PHENIX experiment that included the new hadron-blind detector. The invariant yield of electrons from heavy-flavor decays is measured as a function of transverse momentum in the range $1

Published
2014

16. Measurement of $\Upsilon$(1S+2S+3S) production in $p$$+$$p$ and Au$+$Au collisions at $\sqrt{s_{_{NN}}}=200$ GeV

Author

Adare, A., Afanasiev, S., Aidala, C., Ajitanand, N. N., Akiba, Y., Akimoto, R., Al-Bataineh, H., Al-Ta'ani, H., Alexander, J., Angerami, A., Aoki, K., Apadula, N., Aphecetche, L., Aramaki, Y., Asai, J., Asano, H., Aschenauer, E. C., Atomssa, E. T., Averbeck, R., Awes, T. C., Azmoun, B., Babintsev, V., Bai, M., Baksay, G., Baksay, L., Baldisseri, A., Bannier, B., Barish, K. N., Barnes, P. D., Bassalleck, B., Basye, A. T., Bathe, S., Batsouli, S., Baublis, V., Baumann, C., Baumgart, S., Bazilevsky, A., Belikov, S., Belmont, R., Bennett, R., Berdnikov, A., Berdnikov, Y., Bickley, A. A., Bing, X., Blau, D. S., Boissevain, J. G., Bok, J. S., Borel, H., Boyle, K., Brooks, M. L., Buesching, H., Bumazhnov, V., Bunce, G., Butsyk, S., Camacho, C. M., Campbell, S., Castera, P., Chang, B. S., Chang, W. C., Charvet, J. -L., Chen, C. -H., Chernichenko, S., Chi, C. Y., Chiu, M., Choi, I. J., Choi, J. B., Choi, S., Choudhury, R. K., Christiansen, P., Chujo, T., Chung, P., Churyn, A., Chvala, O., Cianciolo, V., Citron, Z., Cole, B. A., Connors, M., Constantin, P., Csanád, M., Csörgő, T., Dahms, T., Dairaku, S., Das, K., Datta, A., Daugherity, M. S., David, G., Denisov, A., d'Enterria, D., Deshpande, A., Desmond, E. J., Dharmawardane, K. V., Dietzsch, O., Ding, L., Dion, A., Donadelli, M., Drapier, O., Drees, A., Drees, K. A., Dubey, A. K., Durham, J. M., Durum, A., Dutta, D., Dzhordzhadze, V., D'Orazio, L., Edwards, S., Efremenko, Y. V., Ellinghaus, F., Engelmore, T., Enokizono, A., En'yo, H., Esumi, S., Eyser, K. O., Fadem, B., Fields, D. E., Finger, M., Finger, Jr., M., Fleuret, F., Fokin, S. L., Fraenkel, Z., Frantz, J. E., Franz, A., Frawley, A. D., Fujiwara, K., Fukao, Y., Fusayasu, T., Gainey, K., Gal, C., Garishvili, A., Garishvili, I., Glenn, A., Gong, H., Gong, X., Gonin, M., Gosset, J., Goto, Y., de Cassagnac, R. Granier, Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gunji, T., Guo, L., Gustafsson, H. -Å., Hachiya, T., Henni, A. Hadj, Haggerty, J. S., Hahn, K. I., Hamagaki, H., Han, R., Hanks, J., Hartouni, E. P., Haruna, K., Hashimoto, K., Haslum, E., Hayano, R., He, X., Heffner, M., Hemmick, T. K., Hester, T., Hill, J. C., Hohlmann, M., Hollis, R. S., Holzmann, W., Homma, K., Hong, B., Horaguchi, T., Hori, Y., Hornback, D., Huang, S., Ichihara, T., Ichimiya, R., Iinuma, H., Ikeda, Y., Imai, K., Imrek, J., Inaba, M., Iordanova, A., Isenhower, D., Ishihara, M., Isobe, T., Issah, M., Isupov, A., Ivanischev, D., Ivanishchev, D., Jacak, B. V., Javani, M., Jia, J., Jiang, X., Jin, J., Johnson, B. M., Joo, K. S., Jouan, D., Jumper, D. S., Kajihara, F., Kametani, S., Kamihara, N., Kamin, J., Kaneti, S., Kang, B. H., Kang, J. H., Kang, J. S., Kapustinsky, J., Karatsu, K., Kasai, M., Kawall, D., Kazantsev, A. V., Kempel, T., Khanzadeev, A., Kijima, K. M., Kikuchi, J., Kim, B. I., Kim, C., Kim, D. H., Kim, D. J., Kim, E., Kim, E. -J., Kim, H. J., Kim, K. -B., Kim, S. H., Kim, Y. -J., Kim, Y. K., Kinney, E., Kiriluk, K., Kiss, Á., Kistenev, E., Klatsky, J., Klay, J., Klein-Boesing, C., Kleinjan, D., Kline, P., Kochenda, L., Komatsu, Y., Komkov, B., Konno, M., Koster, J., Kotchetkov, D., Kotov, D., Kozlov, A., Král, A., Kravitz, A., Krizek, F., Kunde, G. J., Kurita, K., Kurosawa, M., Kweon, M. J., Kwon, Y., Kyle, G. S., Lacey, R., Lai, Y. S., Lajoie, J. G., Layton, D., Lebedev, A., Lee, B., Lee, D. M., Lee, J., Lee, K. B., Lee, K. S., Lee, S. H., Lee, S. R., Lee, T., Leitch, M. J., Leite, M. A. L., Leitgab, M., Lenzi, B., Lewis, B., Li, X., Liebing, P., Lim, S. H., Levy, L. A. Linden, Liška, T., Litvinenko, A., Liu, H., Liu, M. X., Love, B., Lynch, D., Maguire, C. F., Makdisi, Y. I., Makek, M., Malakhov, A., Malik, M. D., Manion, A., Manko, V. I., Mannel, E., Mao, Y., Mašek, L., Masui, H., Masumoto, S., Matathias, F., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Means, N., Mendoza, M., Meredith, B., Miake, Y., Mibe, T., Mignerey, A. C., Mikeš, P., Miki, K., Milov, A., Mishra, D. K., Mishra, M., Mitchell, J. T., Miyachi, Y., Miyasaka, S., Mohanty, A. K., Moon, H. J., Morino, Y., Morreale, A., Morrison, D. P., Motschwiller, S., Moukhanova, T. V., Mukhopadhyay, D., Murakami, T., Murata, J., Nagae, T., Nagamiya, S., Nagle, J. L., Naglis, M., Nagy, M. I., Nakagawa, I., Nakamiya, Y., Nakamura, K. R., Nakamura, T., Nakano, K., Nattrass, C., Nederlof, A., Newby, J., Nguyen, M., Nihashi, M., Niida, T., Nouicer, R., Novitzky, N., Nyanin, A. S., O'Brien, E., Oda, S. X., Ogilvie, C. A., Oka, M., Okada, K., Onuki, Y., Oskarsson, A., Ouchida, M., Ozawa, K., Pak, R., Palounek, A. P. T., Pantuev, V., Papavassiliou, V., Park, B. H., Park, I. H., Park, J., Park, S. K., Park, W. J., Pate, S. F., Patel, L., Pei, H., Peng, J. -C., Pereira, H., Peresedov, V., Peressounko, D. Yu., Petti, R., Pinkenburg, C., Pisani, R. P., Proissl, M., Purschke, M. L., Purwar, A. K., Qu, H., Rak, J., Rakotozafindrabe, A., Ravinovich, I., Read, K. F., Rembeczki, S., Reygers, K., Reynolds, D., Riabov, V., Riabov, Y., Richardson, E., Riveli, N., Roach, D., Roche, G., Rolnick, S. D., Rosati, M., Rosendahl, S. S. E., Rosnet, P., Rukoyatkin, P., Ružička, P., Rykov, V. L., Sahlmueller, B., Saito, N., Sakaguchi, T., Sakai, S., Sakashita, K., Samsonov, V., Sano, M., Sarsour, M., Sato, T., Sawada, S., Sedgwick, K., Seele, J., Seidl, R., Semenov, A. Yu., Semenov, V., Sen, A., Seto, R., Sharma, D., Shein, I., Shibata, T. -A., Shigaki, K., Shimomura, M., Shoji, K., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Silvestre, C., Sim, K. S., Singh, B. K., Singh, C. P., Singh, V., Slunečka, M., Soldatov, A., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Soumya, M., Sourikova, I. V., Staley, F., Stankus, P. W., Stenlund, E., Stepanov, M., Ster, A., Stoll, S. P., Sugitate, T., Suire, C., Sukhanov, A., Sun, J., Sziklai, J., Takagui, E. M., Takahara, A., Taketani, A., Tanabe, R., Tanaka, Y., Taneja, S., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tarján, P., Tennant, E., Themann, H., Thomas, T. L., Todoroki, T., Togawa, M., Toia, A., Tomášek, L., Tomášek, M., Tomita, Y., Torii, H., Towell, R. S., Tram, V-N., Tserruya, I., Tsuchimoto, Y., Tsuji, T., Vale, C., Valle, H., van Hecke, H. W., Vargyas, M., Vazquez-Zambrano, E., Veicht, A., Velkovska, J., Vértesi, R., Vinogradov, A. A., Virius, M., Vossen, A., Vrba, V., Vznuzdaev, E., Wang, X. R., Watanabe, D., Watanabe, K., Watanabe, Y., Watanabe, Y. S., Wei, F., Wei, R., Wessels, J., Whitaker, S., White, S. N., Winter, D., Wolin, S., Woody, C. L., Wysocki, M., Xie, W., Yamaguchi, Y. L., Yamaura, K., Yang, R., Yanovich, A., Ying, J., Yokkaichi, S., You, Z., Young, G. R., Younus, I., Yushmanov, I. E., Zajc, W. A., Zaudtke, O., Zelenski, A., Zhang, C., Zhou, S., and Zolin, L.

Subjects
Nuclear Experiment
Abstract

Measurements of bottomonium production in heavy ion and $p$$+$$p$ collisions at the Relativistic Heavy Ion Collider (RHIC) are presented. The inclusive yield of the three $\Upsilon$ states, $\Upsilon(1S+2S+3S)$, was measured in the PHENIX experiment via electron-positron decay pairs at midrapidity for Au$+$Au and $p$$+$$p$ collisions at $\sqrt{s_{_{NN}}}=200$ GeV. The $\Upsilon(1S+2S+3S)\rightarrow e^+e^-$ differential cross section at midrapidity was found to be $B_{\rm ee} d\sigma/dy =$ 108 $\pm$ 38 (stat) $\pm$ 15(syst) $\pm$ 11 (luminosity) pb in $p$$+$$p$ collisions. The nuclear modification factor in the 30\% most central Au$+$Au collisions indicates a suppression of the total $\Upsilon$ state yield relative to the extrapolation from $p$$+$$p$ collision data. The suppression is consistent with measurements made by STAR at RHIC and at higher energies by the CMS experiment at the Large Hadron Collider., Comment: 506 authors, 15 pages, 17 figures, and 7 tables. v3 is as accepted by Phys. Rev. C. v2 has changes to text and figures, plus additional authors. Published version will be at http://www.phenix.bnl.gov/phenix/WWW/info/pp1/1NN/ Plain text data tables are (or will be) at http://www.phenix.bnl.gov/papers.html

Published
2014
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17. Nuclear matter effects on $J/\psi$ production in asymmetric Cu+Au collisions at $\sqrt{s_{_{NN}}}$ = 200 GeV

Author

Aidala, C., Ajitanand, N. N., Akiba, Y., Akimoto, R., Alexander, J., Aoki, K., Apadula, N., Asano, H., Atomssa, E. T., Awes, T. C., Azmoun, B., Babintsev, V., Bai, M., Bai, X., Bannier, B., Barish, K. N., Bathe, S., Baublis, V., Baumann, C., Baumgart, S., Bazilevsky, A., Beaumier, M., Belmont, R., Berdnikov, A., Berdnikov, Y., Bing, X., Black, D., Blau, D. S., Bok, J., Boyle, K., Brooks, M. L., Bryslawskyj, J., Buesching, H., Bumazhnov, V., Butsyk, S., Campbell, S., Chen, C. -H., Chi, C. Y., Chiu, M., Choi, I. J., Choi, J. B., Choi, S., Christiansen, P., Chujo, T., Cianciolo, V., Cole, B. A., Cronin, N., Crossette, N., Csanád, M., Csörgő, T., Datta, A., Daugherity, M. S., David, G., Dehmelt, K., Denisov, A., Deshpande, A., Desmond, E. J., Ding, L., Do, J. H., Drapier, O., Drees, A., Drees, K. A., Durham, J. M., Durum, A., D'Orazio, L., Engelmore, T., Enokizono, A., Esumi, S., Eyser, K. O., Fadem, B., Fields, D. E., Finger, M., Finger, Jr., M., Fleuret, F., Fokin, S. L., Frantz, J. E., Franz, A., Frawley, A. D., Fukao, Y., Gainey, K., Gal, C., Garg, P., Garishvili, A., Garishvili, I., Giordano, F., Glenn, A., Gong, X., Gonin, M., Goto, Y., de Cassagnac, R. Granier, Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gu, Y., Gunji, T., Guragain, H., Haggerty, J. S., Hahn, K. I., Hamagaki, H., Hanks, J., Hashimoto, K., Hayano, R., He, X., Hemmick, T. K., Hester, T., Hill, J. C., Hollis, R. S., Homma, K., Hong, B., Hoshino, T., Huang, J., Huang, S., Ichihara, T., Ikeda, Y., Imai, K., Imazu, Y., Inaba, M., Iordanova, A., Isenhower, D., Isinhue, A., Ivanishchev, D., Jacak, B. V., Jeon, S. J., Jezghani, M., Jia, J., Jiang, X., Johnson, B. M., Joo, K. S., Jouan, D., Jumper, D. S., Kamin, J., Kanda, S., Kang, B. H., Kang, J. H., Kang, J. S., Kapustinsky, J., Kawall, D., Kazantsev, A. V., Key, J. A., Khachatryan, V., Khandai, P. K., Khanzadeev, A., Kijima, K. M., Kim, C., Kim, D. J., Kim, E. -J., Kim, Y. -J., Kim, Y. K., Kistenev, E., Klatsky, J., Kleinjan, D., Kline, P., Koblesky, T., Kofarago, M., Komkov, B., Koster, J., Kotchetkov, D., Kotov, D., Krizek, F., Kurita, K., Kurosawa, M., Kwon, Y., Lacey, R., Lai, Y. S., Lajoie, J. G., Lebedev, A., Lee, D. M., Lee, G. H., Lee, J., Lee, K. B., Lee, K. S., Lee, S. H., Leitch, M. J., Leitgab, M., Lewis, B., Li, X., Lim, S. H., Liu, M. X., Lynch, D., Maguire, C. F., Makdisi, Y. I., Makek, M., Manion, A., Manko, V. I., Mannel, E., Maruyama, T., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Meles, A., Mendoza, M., Meredith, B., Miake, Y., Mibe, T., Mignerey, A. C., Milov, A., Mishra, D. K., Mitchell, J. T., Miyasaka, S., Mizuno, S., Mohanty, A. K., Morrison, D. P., Moskowitz, M., Moukhanova, T. V., Murakami, T., Murata, J., Nagae, T., Nagamiya, S., Nagle, J. L., Nagy, M. I., Nakagawa, I., Nakamiya, Y., Nakamura, K. R., Nakamura, T., Nakano, K., Nattrass, C., Netrakanti, P. K., Nihashi, M., Niida, T., Nouicer, R., Novak, T., Novitzky, N., Nyanin, A. S., O'Brien, E., Ogilvie, C. A., Oide, H., Okada, K., Oskarsson, A., Ozawa, K., Pak, R., Pantuev, V., Papavassiliou, V., Park, I. H., Park, S., Park, S. K., Pate, S. F., Patel, L., Peng, J. -C., Perepelitsa, D., Perera, G. D. N., Peressounko, D. Yu., Perry, J., Petti, R., Pinkenburg, C., Pisani, R. P., Purschke, M. L., Qu, H., Rak, J., Ravinovich, I., Read, K. F., Reynolds, D., Riabov, V., Riabov, Y., Richardson, E., Riveli, N., Roach, D., Rolnick, S. D., Rosati, M., Ryu, M. S., Sahlmueller, B., Saito, N., Sakaguchi, T., Sako, H., Samsonov, V., Sarsour, M., Sato, S., Sawada, S., Sedgwick, K., Seele, J., Seidl, R., Sekiguchi, Y., Sen, A., Seto, R., Sett, P., Sharma, D., Shaver, A., Shein, I., Shibata, T. -A., Shigaki, K., Shimomura, M., Shoji, K., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Singh, B. K., Singh, C. P., Singh, V., Skolnik, M., Slunečka, M., Solano, S., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Soumya, M., Sourikova, I. V., Stankus, P. W., Steinberg, P., Stenlund, E., Stepanov, M., Ster, A., Stoll, S. P., Stone, M. R., Sugitate, T., Sukhanov, A., Sun, J., Takahara, A., Taketani, A., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tennant, E., Timilsina, A., Todoroki, T., Tomášek, M., Torii, H., Towell, R. S., Tserruya, I., van Hecke, H. W., Vargyas, M., Vazquez-Zambrano, E., Veicht, A., Velkovska, J., Vértesi, R., Virius, M., Vrba, V., Vznuzdaev, E., Wang, X. R., Watanabe, D., Watanabe, K., Watanabe, Y., Watanabe, Y. S., Wei, F., Whitaker, S., Wolin, S., Woody, C. L., Wysocki, M., Yamaguchi, Y. L., Yanovich, A., Yokkaichi, S., Yoon, I., You, Z., Younus, I., Yushmanov, I. E., Zajc, W. A., Zelenski, A., and Zhou, S.

Subjects
Nuclear Experiment
Abstract

We report on $J/\psi$ production from asymmetric Cu+Au heavy-ion collisions at $\sqrt{s_{_{NN}}}$=200 GeV at the Relativistic Heavy Ion Collider at both forward (Cu-going direction) and backward (Au-going direction) rapidities. The nuclear modification of $J/\psi$ yields in Cu$+$Au collisions in the Au-going direction is found to be comparable to that in Au$+$Au collisions when plotted as a function of the number of participating nucleons. In the Cu-going direction, $J/\psi$ production shows a stronger suppression. This difference is comparable in magnitude and has the same sign as the difference expected from shadowing effects due to stronger low-$x$ gluon suppression in the larger Au nucleus. The relative suppression is opposite to that expected from hot nuclear matter dissociation, since a higher energy density is expected in the Au-going direction., Comment: 349 authors, 10 pages, 4 figures, and 4 tables. Submitted to Phys. Rev. C. For v2, fixed LaTeX error in 3rd-to-last sentence. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.html

Published
2014
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18. Corruption in Health Systems: The Conversation Has Started, Now Time to Continue it; Comment on 'We Need to Talk About Corruption in Health Systems'

Author

Hongsheng S. Lu, Bing X. Ho, and J. Jaime Miranda

Subjects
corruption, health systems, global health, peru, Public aspects of medicine, RA1-1270
Abstract

Holistic and multi-disciplinary responses should be prioritized given the depth and breadth through which corruption in the healthcare sector can cover. Here, taking the Peruvian context as an example, we will reflect on the issue of corruption in health systems, including corruption with roots within and outside the health sector, and ongoing efforts to combat it. Our reflection of why corruption in health systems in settings with individual and systemic corruption should be an issue that is taken more seriously in Peru and beyond aligns with broader global health goals of improving health worldwide. Addressing corruption also serves as a pragmatic approach to health system strengthening and weakens a barrier to achieving universal health coverage and Sustainable Development Goals related to health and justice. Moreover, we will argue that by pushing towards a practice of normalizing the conversation about corruption in health has additional benefits, including expanding the problematization to a wider audience and therefore engaging with communities. For young researchers and global health professionals with interests in improving health systems in the early career stages, corruption in health systems is an issue that could move to the forefront of the list of global health challenges. This is a challenge that is uniquely multi-disciplinary, spanning the health, economy, and legal sectors, with wider societal implications.

Published
2020
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19. Medium modification of jet fragmentation in Au+Au collisions at sqrt(s_NN)=200 GeV measured in direct photon-hadron correlations

Author

Adare, A., Afanasiev, S., Aidala, C., Ajitanand, N. N., Akiba, Y., Akimoto, R., Al-Bataineh, H., Al-Ta'ani, H., Alexander, J., Angerami, A., Aoki, K., Apadula, N., Aphecetche, L., Aramaki, Y., Armendariz, R., Aronson, S. H., Asai, J., Asano, H., Aschenauer, E. C., Atomssa, E. T., Averbeck, R., Awes, T. C., Azmoun, B., Babintsev, V., Bai, M., Baksay, G., Baksay, L., Baldisseri, A., Bannier, B., Barish, K. N., Barnes, P. D., Bassalleck, B., Basye, A. T., Bathe, S., Batsouli, S., Baublis, V., Baumann, C., Baumgart, S., Bazilevsky, A., Belikov, S., Belmont, R., Bennett, R., Berdnikov, A., Berdnikov, Y., Bickley, A. A., Bing, X., Blau, D. S., Boissevain, J. G., Bok, J. S., Borel, H., Boyle, K., Brooks, M. L., Buesching, H., Bumazhnov, V., Bunce, G., Butsyk, S., Camacho, C. M., Campbell, S., Castera, P., Chang, B. S., Chang, W. C., Charvet, J. -L., Chen, C. -H., Chernichenko, S., Chi, C. Y., Chiba, J., Chiu, M., Choi, I. J., Choi, J. B., Choi, S., Choudhury, R. K., Christiansen, P., Chujo, T., Chung, P., Churyn, A., Chvala, O., Cianciolo, V., Citron, Z., Cleven, C. R., Cole, B. A., Comets, M. P., Connors, M., Constantin, P., Csanád, M., Csörgő, T., Dahms, T., Dairaku, S., Danchev, I., Das, K., Datta, A., Daugherity, M. S., David, G., Deaton, M. B., Dehmelt, K., Delagrange, H., Denisov, A., d'Enterria, D., Deshpande, A., Desmond, E. J., Dharmawardane, K. V., Dietzsch, O., Ding, L., Dion, A., Donadelli, M., Drapier, O., Drees, A., Drees, K. A., Dubey, A. K., Durham, J. M., Durum, A., Dutta, D., Dzhordzhadze, V., D'Orazio, L., Edwards, S., Efremenko, Y. V., Egdemir, J., Ellinghaus, F., Emam, W. S., Engelmore, T., Enokizono, A., En'yo, H., Esumi, S., Eyser, K. O., Fadem, B., Fields, D. E., Finger, M., Finger, Jr., M., Fleuret, F., Fokin, S. L., Fraenkel, Z., Frantz, J. E., Franz, A., Frawley, A. D., Fujiwara, K., Fukao, Y., Fusayasu, T., Gadrat, S., Gainey, K., Gal, C., Garishvili, A., Garishvili, I., Glenn, A., Gong, H., Gong, X., Gonin, M., Gosset, J., Goto, Y., de Cassagnac, R. Granier, Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gunji, T., Guo, L., Gustafsson, H. -Å., Hachiya, T., Henni, A. Hadj, Haegemann, C., Haggerty, J. S., Hahn, K. I., Hamagaki, H., Hamblen, J., Han, R., Hanks, J., Harada, H., Hartouni, E. P., Haruna, K., Hashimoto, K., Haslum, E., Hayano, R., He, X., Heffner, M., Hemmick, T. K., Hester, T., Hiejima, H., Hill, J. C., Hobbs, R., Hohlmann, M., Hollis, R. S., Holzmann, W., Homma, K., Hong, B., Horaguchi, T., Hori, Y., Hornback, D., Huang, S., Ichihara, T., Ichimiya, R., Ide, J., Iinuma, H., Ikeda, Y., Imai, K., Imrek, J., Inaba, M., Inoue, Y., Iordanova, A., Isenhower, D., Isenhower, L., Ishihara, M., Isobe, T., Issah, M., Isupov, A., Ivanischev, D., Jacak, B. V., Javani, M., Jia, J., Jiang, X., Jin, J., Jinnouchi, O., Johnson, B. M., Joo, K. S., Jouan, D., Jumper, D. S., Kajihara, F., Kametani, S., Kamihara, N., Kamin, J., Kaneta, M., Kaneti, S., Kang, B. H., Kang, J. H., Kang, J. S., Kanou, H., Kapustinsky, J., Karatsu, K., Kasai, M., Kawall, D., Kawashima, M., Kazantsev, A. V., Kempel, T., Khanzadeev, A., Kijima, K. M., Kikuchi, J., Kim, B. I., Kim, C., Kim, D. H., Kim, D. J., Kim, E., Kim, E. -J., Kim, H. J., Kim, K. -B., Kim, S. H., Kim, Y. -J., Kim, Y. J., Kim, Y. K., Kinney, E., Kiriluk, K., Kiss, Á., Kistenev, E., Kiyomichi, A., Klatsky, J., Klay, J., Klein-Boesing, C., Kleinjan, D., Kline, P., Kochenda, L., Kochetkov, V., Komatsu, Y., Komkov, B., Konno, M., Koster, J., Kotchetkov, D., Kotov, D., Kozlov, A., Král, A., Kravitz, A., Krizek, F., Kubart, J., Kunde, G. J., Kurihara, N., Kurita, K., Kurosawa, M., Kweon, M. J., Kwon, Y., Kyle, G. S., Lacey, R., Lai, Y. S., Lajoie, J. G., Layton, D., Lebedev, A., Lee, B., Lee, D. M., Lee, J., Lee, K., Lee, K. B., Lee, K. S., Lee, M. K., Lee, S. H., Lee, S. R., Lee, T., Leitch, M. J., Leite, M. A. L., Leitgab, M., Leitner, E., Lenzi, B., Lewis, B., Li, X., Liebing, P., Lim, S. H., Levy, L. A. Linden, Liška, T., Litvinenko, A., Liu, H., Liu, M. X., Love, B., Luechtenborg, R., Lynch, D., Maguire, C. F., Makdisi, Y. I., Makek, M., Malakhov, A., Malik, M. D., Manion, A., Manko, V. I., Mannel, E., Mao, Y., Mašek, L., Masui, H., Masumoto, S., Matathias, F., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Means, N., Mendoza, M., Meredith, B., Miake, Y., Mibe, T., Mignerey, A. C., Mikeš, P., Miki, K., Miller, T. E., Milov, A., Mioduszewski, S., Mishra, D. K., Mishra, M., Mitchell, J. T., Mitrovski, M., Miyachi, Y., Miyasaka, S., Mohanty, A. K., Moon, H. J., Morino, Y., Morreale, A., Morrison, D. P., Motschwiller, S., Moukhanova, T. V., Mukhopadhyay, D., Murakami, T., Murata, J., Nagae, T., Nagamiya, S., Nagata, Y., Nagle, J. L., Naglis, M., Nagy, M. I., Nakagawa, I., Nakamiya, Y., Nakamura, K. R., Nakamura, T., Nakano, K., Nattrass, C., Nederlof, A., Newby, J., Nguyen, M., Nihashi, M., Niita, T., Norman, B. E., Nouicer, R., Novitzky, N., Nyanin, A. S., O'Brien, E., Oda, S. X., Ogilvie, C. A., Ohnishi, H., Oka, M., Okada, K., Omiwade, O. O., Onuki, Y., Oskarsson, A., Ouchida, M., Ozawa, K., Pak, R., Pal, D., Palounek, A. P. T., Pantuev, V., Papavassiliou, V., Park, B. H., Park, I. H., Park, J., Park, S. K., Park, W. J., Pate, S. F., Patel, L., Pei, H., Peng, J. -C., Pereira, H., Peresedov, V., Peressounko, D. Yu., Petti, R., Pinkenburg, C., Pisani, R. P., Proissl, M., Purschke, M. L., Purwar, A. K., Qu, H., Rak, J., Rakotozafindrabe, A., Ravinovich, I., Read, K. F., Rembeczki, S., Reuter, M., Reygers, K., Reynolds, R., Riabov, V., Riabov, Y., Richardson, E., Roach, D., Roche, G., Rolnick, S. D., Romana, A., Rosati, M., Rosen, C. A., Rosendahl, S. S. E., Rosnet, P., Rukoyatkin, P., Ružička, P., Rykov, V. L., Sahlmueller, B., Saito, N., Sakaguchi, T., Sakai, S., Sakashita, K., Sakata, H., Samsonov, V., Sano, M., Sano, S., Sarsour, M., Sato, S., Sato, T., Sawada, S., Sedgwick, K., Seele, J., Seidl, R., Semenov, A. Yu., Semenov, V., Sen, A., Seto, R., Sharma, D., Shein, I., Shevel, A., Shibata, T. -A., Shigaki, K., Shimomura, M., Shoji, K., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Silvestre, C., Sim, K. S., Singh, B. K., Singh, C. P., Singh, V., Skutnik, S., Slunečka, M., Soldatov, A., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Soumya, M., Sourikova, I. V., Sparks, N. A., Staley, F., Stankus, P. W., Stenlund, E., Stepanov, M., Ster, A., Stoll, S. P., Sugitate, T., Suire, C., Sukhanov, A., Sun, J., Sziklai, J., Tabaru, T., Takagi, S., Takagui, E. M., Takahara, A., Taketani, A., Tanabe, R., Tanaka, Y., Taneja, S., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tarján, P., Tennant, E., Themann, H., Thomas, T. L., Todoroki, T., Togawa, M., Toia, A., Tojo, J., Tomášek, L., Tomášek, M., Tomita, Y., Torii, H., Towell, R. S., Tram, V-N., Tserruya, I., Tsuchimoto, Y., Tsuji, T., Vale, C., Valle, H., van Hecke, H. W., Vargyas, M., Vazquez-Zambrano, E., Veicht, A., Velkovska, J., Vértesi, R., Vinogradov, A. A., Virius, M., Vossen, A., Vrba, V., Vznuzdaev, E., Wagner, M., Walker, D., Wang, X. R., Watanabe, D., Watanabe, K., Watanabe, Y., Watanabe, Y. S., Wei, F., Wei, R., Wessels, J., White, S. N., Winter, D., Wolin, S., Wood, J. P., Woody, C. L., Wright, R. M., Wysocki, M., Xie, W., Yamaguchi, Y. L., Yamaura, K., Yang, R., Yanovich, A., Yasin, Z., Ying, J., Yokkaichi, S., You, Z., Young, G. R., Younus, I., Yushmanov, I. E., Zajc, W. A., Zaudtke, O., Zelenski, A., Zhang, C., Zhou, S., Zimányi, J., and Zolin, L.

Subjects
Nuclear Experiment
Abstract

The jet fragmentation function is measured with direct photon-hadron correlations in p+p and Au+Au collisions at sqrt(s_NN)=200 GeV. The p_T of the photon is an excellent approximation to the initial p_T of the jet and the ratio z_T=p_T^h/p_T^\gamma is used as a proxy for the jet fragmentation function. A statistical subtraction is used to extract the direct photon-hadron yields in Au+Au collisions while a photon isolation cut is applied in p+p. I_ AA, the ratio of jet fragment yield in Au+Au to that in p+p, indicates modification of the jet fragmentation function. Suppression, most likely due to energy loss in the medium, is seen at high z_T. The fragment yield at low z_T is enhanced at large angles. Such a trend is expected from redistribution of the lost energy into increased production of low-momentum particles., Comment: 562 authors, 70 insitutions, 8 pages, and 3 figures. Submitted to Phys. Rev. Lett. v2 has minor changes to improve clarity. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.html

Published
2012
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20. J/psi suppression at forward rapidity in Au+Au collisions at sqrt(s_NN)=39 and 62.4 GeV

Author

Adare, A., Aidala, C., Ajitanand, N. N., Akiba, Y., Akimoto, R., Al-Ta'ani, H., Alexander, J., Angerami, A., Aoki, K., Apadula, N., Aramaki, Y., Asano, H., Aschenauer, E. C., Atomssa, E. T., Awes, T. C., Azmoun, B., Babintsev, V., Bai, M., Bannier, B., Barish, K. N., Bassalleck, B., Bathe, S., Baublis, V., Baumgart, S., Bazilevsky, A., Belmont, R., Berdnikov, A., Berdnikov, Y., Bing, X., Blau, D. S., Boyle, K., Brooks, M. L., Buesching, H., Bumazhnov, V., Butsyk, S., Campbell, S., Castera, P., Chen, C. -H., Chi, C. Y., Chiu, M., Choi, I. J., Choi, J. B., Choi, S., Choudhury, R. K., Christiansen, P., Chujo, T., Chvala, O., Cianciolo, V., Citron, Z., Cole, B. A., Connors, M., Csanád, M., Csörgő, T., Dairaku, S., Datta, A., Daugherity, M. S., David, G., Denisov, A., Deshpande, A., Desmond, E. J., Dharmawardane, K. V., Dietzsch, O., Ding, L., Dion, A., Donadelli, M., Drapier, O., Drees, A., Drees, K. A., Durham, J. M., Durum, A., D'Orazio, L., Edwards, S., Efremenko, Y. V., Engelmore, T., Enokizono, A., Esumi, S., Eyser, K. O., Fadem, B., Fields, D. E., Finger, M., Finger Jr, M., Fleuret, F., Fokin, S. L., Frantz, J. E., Franz, A., Frawley, A. D., Fukao, Y., Fusayasu, T., Gainey, K., Gal, C., Garishvili, A., Garishvili, I., Glenn, A., Gong, X., Gonin, M., Goto, Y., de Cassagnac, R. Granier, Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gunji, T., Guo, L., Gustafsson, H. -Å., Hachiya, T., Haggerty, J. S., Hahn, K. I., Hamagaki, H., Hanks, J., Hashimoto, K., Haslum, E., Hayano, R., He, X., Hemmick, T. K., Hester, T., Hill, J. C., Hollis, R. S., Homma, K., Hong, B., Horaguchi, T., Hori, Y., Huang, S., Ichihara, T., Iinuma, H., Ikeda, Y., Imrek, J., Inaba, M., Iordanova, A., Isenhower, D., Issah, M., Ivanischev, D., Jacak, B. V., Javani, M., Jia, J., Jiang, X., Johnson, B. M., Joo, K. S., Jouan, D., Kamin, J., Kaneti, S., Kang, B. H., Kang, J. H., Kang, J. S., Kapustinsky, J., Karatsu, K., Kasai, M., Kawall, D., Kazantsev, A. V., Kempel, T., Khanzadeev, A., Kijima, K. M., Kim, B. I., Kim, C., Kim, D. J., Kim, E. -J., Kim, H. J., Kim, K. -B., Kim, Y. -J., Kim, Y. K., Kinney, E., Kiss, Á., Kistenev, E., Klatsky, J., Kleinjan, D., Kline, P., Komatsu, Y., Komkov, B., Koster, J., Kotchetkov, D., Kotov, D., Král, A., Krizek, F., Kunde, G. J., Kurita, K., Kurosawa, M., Kwon, Y., Kyle, G. S., Lacey, R., Lai, Y. S., Lajoie, J. G., Lebedev, A., Lee, B., Lee, D. M., Lee, J., Lee, K. B., Lee, K. S., Lee, S. H., Lee, S. R., Leitch, M. J., Leite, M. A. L., Leitgab, M., Lewis, B., Lim, S. H., Levy, L. A. Linden, Liu, M. X., Love, B., Maguire, C. F., Makdisi, Y. I., Makek, M., Manion, A., Manko, V. I., Mannel, E., Masumoto, S., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Mendoza, M., Meredith, B., Miake, Y., Mibe, T., Mignerey, A. C., Milov, A., Mishra, D. K., Mitchell, J. T., Miyachi, Y., Miyasaka, S., Mohanty, A. K., Moon, H. J., Morrison, D. P., Motschwiller, S., Moukhanova, T. V., Murakami, T., Murata, J., Nagae, T., Nagamiya, S., Nagle, J. L., Nagy, M. I., Nakagawa, I., Nakamiya, Y., Nakamura, K. R., Nakamura, T., Nakano, K., Nattrass, C., Nederlof, A., Nihashi, M., Nouicer, R., Novitzky, N., Nyanin, A. S., O'Brien, E., Ogilvie, C. A., Okada, K., Oskarsson, A., Ouchida, M., Ozawa, K., Pak, R., Pantuev, V., Papavassiliou, V., Park, B. H., Park, I. H., Park, S. K., Pate, S. F., Patel, L., Pei, H., Peng, J. -C., Pereira, H., Peressounko, D. Yu., Petti, R., Pinkenburg, C., Pisani, R. P., Proissl, M., Purschke, M. L., Qu, H., Rak, J., Ravinovich, I., Read, K. F., Reynolds, R., Riabov, V., Riabov, Y., Richardson, E., Roach, D., Roche, G., Rolnick, S. D., Rosati, M., Sahlmueller, B., Saito, N., Sakaguchi, T., Samsonov, V., Sano, M., Sarsour, M., Sawada, S., Sedgwick, K., Seidl, R., Sen, A., Seto, R., Sharma, D., Shein, I., Shibata, T. -A., Shigaki, K., Shimomura, M., Shoji, K., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Sim, K. S., Singh, B. K., Singh, C. P., Singh, V., Slunečka, M., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Soumya, M., Sourikova, I. V., Stankus, P. W., Stenlund, E., Stepanov, M., Ster, A., Stoll, S. P., Sugitate, T., Sukhanov, A., Sun, J., Sziklai, J., Takagui, E. M., Takahara, A., Taketani, A., Tanaka, Y., Taneja, S., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tennant, E., Themann, H., Todoroki, T., Tomášek, L., Tomášek, M., Torii, H., Towell, R. S., Tserruya, I., Tsuchimoto, Y., Tsuji, T., Vale, C., van Hecke, H. W., Vargyas, M., Vazquez-Zambrano, E., Veicht, A., Velkovska, J., Vértesi, R., Virius, M., Vossen, A., Vrba, V., Vznuzdaev, E., Wang, X. R., Watanabe, D., Watanabe, K., Watanabe, Y., Watanabe, Y. S., Wei, F., Wei, R., White, S. N., Winter, D., Wolin, S., Woody, C. L., Wysocki, M., Yamaguchi, Y. L., Yang, R., Yanovich, A., Ying, J., Yokkaichi, S., You, Z., Younus, I., Yushmanov, I. E., Zajc, W. A., and Zelenski, A.

Subjects
Nuclear Experiment
Abstract

We present measurements of the J/psi invariant yields in sqrt(s_NN)=39 and 62.4 GeV Au+Au collisions at forward rapidity (1.2<|y|<2.2). Invariant yields are presented as a function of both collision centrality and transverse momentum. Nuclear modifications are obtained for central relative to peripheral Au+Au collisions (R_CP) and for various centrality selections in Au+Au relative to scaled p+p cross sections obtained from other measurements (R_AA). The observed suppression patterns at 39 and 62.4 GeV are quite similar to those previously measured at 200 GeV. This similar suppression presents a challenge to theoretical models that contain various competing mechanisms with different energy dependencies, some of which cause suppression and others enhancement., Comment: 365 authors, 10 pages, 11 figures, 4 tables. Submitted to Phys. Rev. C. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.html

Published
2012
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21. sPHENIX: An Upgrade Concept from the PHENIX Collaboration

Author

Adare, A., Aidala, C., Ajitanand, N. N., Akiba, Y., Akimoto, R., Alexander, J., Aoki, K., Apadula, N., Asano, H., Atomssa, E. T., Awes, T. C., Azmoun, B., Babintsev, V., Bai, M., Bai, X., Bandara, N., Bannier, B., Barish, K. N., Baron, O., Bassalleck, B., Bathe, S., Baublis, V., Baumgart, S., Bazilevsky, A., Beaumier, M., Belmont, R., Benjamin, G., Berdnikov, A., Berdnikov, Y., Bing, X., Black, D., Blackburn, J., Blau, D. S., Bobrek, M., Bok, J., Boose, S., Boyle, K., Britton Jr, C. L., Brooks, M. L., Bryslawskyj, J., Bumazhnov, V., Butler, C., Butsyk, S., Campbell, S., Carollo, A., Chai, J. -S., Chen, C. -H., Chernichenko, S., Chi, C. Y., Chiu, M., Choi, I. J., Choi, J. B., Choi, S., Chollet, S., Christiansen, P., Chujo, T., Cianciolo, V., Cole, B. A., Cronin, N., Crossett, N., D'Orazio, L., Dairaku, S., Datta, A., Daugherity, M. S., David, G., DeBlasio, K., Debraine, A., Dehmelt, K., Denisov, A., Deshpande, A., Desmond, E. J., Dietzsch, O., Ding, L., Dion, A., Do, J. H., Donadelli, M., Drapier, O., Drees, A., Drees, K. A., Durham, J. M., Durum, A., Eberle, L., Edwards, S., Efremenko, Y. V., Engelmore, T., Enokizono, A., Esumi, S., Eyser, K. O., Fadem, B., Fields, D. E., Finger, M., Finger Jr, M., Fleuret, F., Fokin, S. L., Frantz, J. E., Franz, A., Frawley, A. D., Fukao, Y., Fusayasu, T., Gainey, K., Gal, C., Garg, P., Garishvili, A., Garishvili, I., Gastaldi, F., Ge, H., Giannotti, P., Giordarno, F., Glenn, A., Gong, X., Gonin, M., Goto, Y., de Cassagnac, R. Granier, Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gu, Y., Gunji, T., Guragain, H., Haggerty, J. S., Hahn, K. I., Hamagaki, H., Han, S. Y., Hanks, J., Hashimoto, K., Hayano, R., Hayashi, S., He, X., Hemmick, T. K., Hester, T., Hill, J. C., Hoefferkamp, M., Hollis, R. S., Homma, K., Hong, B., Hori, Y., Hoshino, T., Huang, J., Huang, S., Hutchins, J. R., Ichihara, T., Ikeda, Y., Imai, K., Imazu, Y., Imrek, J., Inaba, M., Iordanova, A., Isenhower, D., Isinhue, A., Ivanischev, D., Ivanov, V., Jacak, B. V., Jeon, S. J., Jezghani, M., Jia, J., Jiang, X., Johnson, B. M., Joo, K. S., Jouan, D., Jumper, D. S., Kamin, J., Kanda, S., Kang, B. H., Kang, J. H., Kang, J. S., Kapustinsky, J., Karatsu, K., Kawall, D., Kazantsev, A. V., Kehayias, H. -J., Key, J. A., Khachatryan, V., Khandai, P. K., Khanzadeev, A., Kijima, K. M., Kim, C., Kim, D. H., Kim, D. J., Kim, E. -J., Kim, H. J., Kim, K. -B., Kim, Y. -J., Kim, Y. K., Kistenev, E., Klatsky, J., Kleinjan, D., Kline, P., Koblesky, T., Kochenda, L., Kofarago, M., Komatsu, Y., Komkov, B., Koster, J., Kotchetkov, D., Kotov, D., Kravtsov, P., Krizek, F., Kurita, K., Kuriyama, M., Kurosawa, M., Kwon, Y., Lacey, R., Lai, Y. S., Lajoie, J. G., Lebedev, A., Lee, G. H., Lee, J., Lee, K. B., Lee, K. S., Lee, S. H., Lefferts, R., Leitch, M. J., Leite, M. A. L., Leitgab, M., Lewis, B., Li, X., Lim, S. H., Lipski, A., Liu, M. X., Love, B., Lynch, D., Lynch, M., Maguire, C. F., Makdisi, Y. I., Makek, M., Manion, A., Manko, V. I., Mannel, E., Maruyama, T., Masumoto, S., McCumber, M., McGaughey, P. L., McGlinchey, D., McKay, R., McKinney, C., Meles, A., Mendoza, M., Menegasso, R., Meredith, B., Miake, Y., Mibe, T., Mignerey, A. C., Milov, A., Mishra, D. K., Mitchell, J. T., Miyasaka, S., Mizuno, S., Mohanty, A. K., Morrison, D. P., Moskowitz, M., Motschwiller, S., Moukhanova, T. V., Murakami, T., Murata, J., Mwai, A., Nagae, T., Nagamiya, S., Nagle, J. L., Nagy, M. I., Nakagawa, I., Nakamiya, Y., Nakamura, K. R., Nakamura, T., Nakano, K., Nattrass, C., Nederlof, A., Netrakanti, P. K., Nihashi, M., Niida, T., Ninomiya, K., Northacker, D., Nouicer, R., Novak, T., Novitzky, N., Nukariya, A., Nyanin, A. S., O'Brien, E., Ogilvie, C. A., Oide, H., Okada, K., Oskarsson, A., Ozawa, K., Pak, R., Pancake, C., Pantuev, V., Papavassiliou, V., Park, I. H., Park, S., Park, S. K., Pate, S. F., Patel, L., Peng, J. -C., Perepelitsa, D., Perera, G. D. N., Peressounko, D. Yu., Perry, J., Petti, R., Pinkenburg, C., Pisani, R. P., Popule, J., Purschke, M. L., Qu, H., Radhakrishnan, S., Rak, J., Ravinovich, I., Read, K. F., Reynolds, R., Riabov, V., Riabov, Y., Richardson, E., Riveli, N., Roach, D., Rolnick, S. D., Rosati, M., Roschin, E., Ryu, M. S., Safonov, A., Sahlmueller, B., Saito, N., Sakaguchi, T., Sako, H., Samsonov, V., Sano, M., Sarsour, M., Sato, S., Sawada, S., Schaefer, B., Sedgwick, K., Seele, J., Seidl, R., Sekiguchi, Y., Sen, A., Seto, R., Sett, P., Shafto, E., Sharma, D., Shaver, A., Shein, I., Shibata, T. -A., Shigaki, K., Shimomura, M., Shoji, K., Shukla, P., Sicho, P., Sickles, A., Silva, C. L., Silvermyr, D., Singh, B. K., Singh, C. P., Singh, V., Sippach, F. W., Skolnik, M., Solano, S., Soldatov, A., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Soumya, M., Sourikova, I. V., Srivastava, P. K., Stankus, P. W., Steinberg, P., Stenlund, E., Stepanov, M., Ster, A., Stevens, L., Stoll, S. P., Stone, M. R., Sugitate, T., Sukhanov, A., Sun, J., Sziklai, J., Takagui, E. M., Takahara, A., Taketani, A., Tanaka, Y., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tate, A., Tennant, E., Thorsland, E., Timilsina, A., Todoroki, T., Torii, H., Towell, R., Towell, R. S., Trofimov, V., Tserruya, I., Tsuji, T., Tullo, A., van Hecke, H. W., Vargyas, M., Vazquez-Zambrano, E., Veicht, A., Velkovska, J., Virius, M., Vrba, V., Vznuzdaev, E., Wang, X. R., Watanabe, D., Watanabe, K., Watanabe, Y., Watanabe, Y. S., Watson, T. S., Wei, F., Wei, R., Whitaker, S., Winter, D., Wolin, S., Woody, C. L., Wysocki, M., Yamaguchi, Y. L., Yang, R., Yanovich, A., Yokkaichi, S., Yoon, I., Young, M., Younus, I., Yushmanov, I. E., Zajc, W. A., Zarndt, E., Zelenski, A., Zhang, L., Zhou, S., and Zumberge, C.

Subjects
Nuclear Experiment, High Energy Physics - Experiment
Abstract

The PHENIX collaboration presents a concept for a major upgrade to the PHENIX detector at the Relativistic Heavy Ion Collider (RHIC). This upgrade, referred to as sPHENIX, brings exciting new capability to the RHIC program by opening new and important channels for experimental investigation and utilizing fully the luminosity of the recently upgraded RHIC facility. sPHENIX enables a compelling jet physics program that will address fundamental questions about the nature of the strongly coupled quark-gluon plasma discovered experimentally at RHIC to be a perfect fluid. The upgrade concept addresses specific questions whose answers are necessary to advance our understanding of the quark-gluon plasma: (1) How to reconcile the observed strongly coupled quark-gluon plasma with the asymptotically free theory of quarks and gluons? (2) What are the dynamical changes to the quark-gluon plasma in terms of quasiparticles and excitations as a function of temperature? (3) How sharp is the transition of the quark-gluon plasma from the most strongly coupled regime near Tc to a weakly coupled system of partons known to emerge at asymptotically high temperatures? In three Appendices, we detail the additional physics capabilities gained through further upgrades: (A) two midrapidity detector additions, (B) a forward rapidity upgrade, and (C) an evolution to an ePHENIX detector suitable for a future Electron Ion Collider at RHIC., Comment: 427 authors, 63 institutions, 159 pages. v2 has correction only to the author list. Two names were inadvertently omitted in v1 and some names were duplicated. There are no changes to the document, but now the arXiv author lists matches the author list in the document

Published
2012

22. Evolution of pi^0 suppression in Au+Au collisions from sqrt(s_NN) = 39 to 200 GeV

Author

Adare, A., Afanasiev, S., Aidala, C., Ajitanand, N. N., Akiba, Y., Akimoto, R., Al-Ta'ani, H., Alexander, J., Angerami, A., Aoki, K., Apadula, N., Aramaki, Y., Asano, H., Aschenauer, E. C., Atomssa, E. T., Awes, T. C., Azmoun, B., Babintsev, V., Bai, M., Bannier, B., Barish, K. N., Bassalleck, B., Bathe, S., Baublis, V., Baumgart, S., Bazilevsky, A., Belmont, R., Berdnikov, A., Berdnikov, Y., Bing, X., Blau, D. S., Boyle, K., Brooks, M. L., Buesching, H., Bumazhnov, V., Butsyk, S., Campbell, S., Castera, P., Chen, C. -H., Chi, C. Y., Chiu, M., Choi, I. J., Choi, J. B., Choi, S., Choudhury, R. K., Christiansen, P., Chujo, T., Chvala, O., Cianciolo, V., Citron, Z., Cole, B. A., Connors, M., Csanád, M., Csörgő, T., Dairaku, S., Datta, A., Daugherity, M. S., David, G., Denisov, A., Deshpande, A., Desmond, E. J., Dharmawardane, K. V., Dietzsch, O., Ding, L., Dion, A., Donadelli, M., Drapier, O., Drees, A., Drees, K. A., Durham, J. M., Durum, A., D'Orazio, L., Edwards, S., Efremenko, Y. V., Engelmore, T., Enokizono, A., Esumi, S., Eyser, K. O., Fadem, B., Fields, D. E., Finger, M., Finger Jr, M., Fleuret, F., Fokin, S. L., Frantz, J. E., Franz, A., Frawley, A. D., Fukao, Y., Fusayasu, T., Gainey, K., Gal, C., Garishvili, A., Garishvili, I., Glenn, A., Gong, X., Gonin, M., Goto, Y., de Cassagnac, R. Granier, Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gunji, T., Guo, L., Gustafsson, H. -Å., Hachiya, T., Haggerty, J. S., Hahn, K. I., Hamagaki, H., Hanks, J., Hashimoto, K., Haslum, E., Hayano, R., He, X., Hemmick, T. K., Hester, T., Hill, J. C., Hollis, R. S., Homma, K., Hong, B., Horaguchi, T., Hori, Y., Huang, S., Ichihara, T., Iinuma, H., Ikeda, Y., Imrek, J., Inaba, M., Iordanova, A., Isenhower, D., Issah, M., Isupov, A., Ivanischev, D., Jacak, B. V., Javani, M., Jia, J., Jiang, X., Johnson, B. M., Joo, K. S., Jouan, D., Kamin, J., Kaneti, S., Kang, B. H., Kang, J. H., Kang, J. S., Kapustinsky, J., Karatsu, K., Kasai, M., Kawall, D., Kazantsev, A. V., Kempel, T., Khanzadeev, A., Kijima, K. M., Kim, B. I., Kim, C., Kim, D. J., Kim, E. J., Kim, H. J., Kim, K. -B., Kim, Y. -J., Kim, Y. K., Kinney, E., Kiss, Á., Kistenev, E., Klatsky, J., Kleinjan, D., Kline, P., Komatsu, Y., Komkov, B., Koster, J., Kotchetkov, D., Kotov, D., Král, A., Krizek, F., Kunde, G. J., Kurita, K., Kurosawa, M., Kwon, Y., Kyle, G. S., Lacey, R., Lai, Y. S., Lajoie, J. G., Lebedev, A., Lee, B., Lee, D. M., Lee, J., Lee, K. B., Lee, K. S., Lee, S. H., Lee, S. R., Leitch, M. J., Leite, M. A. L., Leitgab, M., Lewis, B., Lim, S. H., Levy, L. A. Linden, Litvinenko, A., Liu, M. X., Love, B., Maguire, C. F., Makdisi, Y. I., Makek, M., Malakhov, A., Manion, A., Manko, V. I., Mannel, E., Masumoto, S., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Mendoza, M., Meredith, B., Miake, Y., Mibe, T., Mignerey, A. C., Milov, A., Mishra, D. K., Mitchell, J. T., Miyachi, Y., Miyasaka, S., Mohanty, A. K., Moon, H. J., Morrison, D. P., Motschwiller, S., Moukhanova, T. V., Murakami, T., Murata, J., Nagae, T., Nagamiya, S., Nagle, J. L., Nagy, M. I., Nakagawa, I., Nakamiya, Y., Nakamura, K. R., Nakamura, T., Nakano, K., Nattrass, C., Nederlof, A., Nihashi, M., Nouicer, R., Novitzky, N., Nyanin, A. S., O'Brien, E., Ogilvie, C. A., Okada, K., Oskarsson, A., Ouchida, M., Ozawa, K., Pak, R., Papavassiliou, V., Park, B. H., Park, I. H., Park, S. K., Pate, S. F., Patel, L., Pei, H., Peng, J. -C., Pereira, H., Peresedov, V., Peressounko, D. Yu., Petti, R., Pinkenburg, C., Pisani, R. P., Proissl, M., Purschke, M. L., Qu, H., Rak, J., Ravinovich, I., Read, K. F., Reynolds, R., Riabov, V., Riabov, Y., Richardson, E., Roach, D., Roche, G., Rolnick, S. D., Rosati, M., Rukoyatkin, P., Sahlmueller, B., Saito, N., Sakaguchi, T., Samsonov, V., Sano, M., Sarsour, M., Sawada, S., Sedgwick, K., Seidl, R., Sen, A., Seto, R., Sharma, D., Shein, I., Shibata, T. -A., Shigaki, K., Shimomura, M., Shoji, K., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Sim, K. S., Singh, B. K., Singh, C. P., Singh, V., Slunečka, M., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Soumya, M., Sourikova, I. V., Stankus, P. W., Stenlund, E., Stepanov, M., Ster, A., Stoll, S. P., Sugitate, T., Sukhanov, A., Sun, J., Sziklai, J., Takagui, E. M., Takahara, A., Taketani, A., Tanaka, Y., Taneja, S., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tennant, E., Themann, H., Todoroki, T., Tomášek, L., Tomášek, M., Torii, H., Towell, R. S., Tserruya, I., Tsuchimoto, Y., Tsuji, T., Vale, C., van Hecke, H. W., Vargyas, M., Vazquez-Zambrano, E., Veicht, A., Velkovska, J., Vértesi, R., Virius, M., Vossen, A., Vrba, V., Vznuzdaev, E., Wang, X. R., Watanabe, D., Watanabe, K., Watanabe, Y., Watanabe, Y. S., Wei, F., Wei, R., White, S. N., Winter, D., Wolin, S., Woody, C. L., Wysocki, M., Yamaguchi, Y. L., Yang, R., Yanovich, A., Ying, J., Yokkaichi, S., You, Z., Younus, I., Yushmanov, I. E., Zajc, W. A., Zelenski, A., and Zolin, L.

Subjects
Nuclear Experiment
Abstract

Neutral-pion, pi^0, spectra were measured at midrapidity (|y|<0.35) in Au+Au collisions at sqrt(s_NN) = 39 and 62.4 GeV and compared to earlier measurements at 200 GeV in the 1

Published
2012
Full Text
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24. Conditional Knock out of High-Mobility Group Box 1 (HMGB1) in Rods Reduces Autophagy Activation after Retinal Detachment

Author

Bing X. Ross, Lin Jia, Dejuan Kong, Tiantian Wang, Heather M. Hager, Steven F. Abcouwer, and David N. Zacks

Subjects
retinal detachment, HMGB1, photoreceptor, autophagy, apoptosis, Cytology, QH573-671
Abstract

After retinal detachment (RD), the induction of autophagy protects photoreceptors (PR) from apoptotic cell death. The cytoplasmic high-mobility group box 1 (HMGB1) promotes autophagy. We previously demonstrated that the deletion of HMGB1 from rod PRs results in a more rapid death of these cells after RD. In this work, we tested the hypothesis that the lack of HMGB1 accelerates PR death after RD due to the reduced activation of protective autophagy in the retina after RD. The injection of 1% hyaluronic acid into the subretinal space was used to create acute RD in mice with a rhodopsin-Cre-mediated conditional knockout (cKO) of HMGB1 in rods (HMGB1Δrod) and littermate controls. RD sharply increased the number of apoptotic cells in the outer nuclear layer (ONL), and this number was further increased in HMGB1Δrod mouse retinas. The activation of autophagy after RD was reduced in the HMGB1Δrod mouse retinas compared to controls, as evidenced by diminished levels of autophagy regulatory proteins LC3-II, Beclin1, ATG5/12, and phospho-ATG16L1. The cKO of HMGB1 in rods increased the expression of Fas and the Bax/Bcl-2 ratio in detached retinas, promoting apoptotic cell death. In conclusion, endogenous HMGB1 facilitates autophagy activation in PR cells following RD to promote PR cell survival and reduce programmed apoptotic cell death.

Published
2021
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28. Endosymbionts Reduce Microbiome Diversity and Modify Host Metabolism and Fecundity in the Planthopper Sogatella furcifera.

Author

Milligan-McClellan, KC, Li, T-P, Zhou, C-Y, Wang, M-K, Zha, S-S, Chen, J, Bing, X-L, Hoffmann, AA, Hong, X-Y, Milligan-McClellan, KC, Li, T-P, Zhou, C-Y, Wang, M-K, Zha, S-S, Chen, J, Bing, X-L, Hoffmann, AA, and Hong, X-Y

Abstract

Endosymbionts can strongly affect bacterial microbiota in pests. The white-backed planthopper Sogatella furcifera, a notorious pest in rice, is usually co-infected with Cardinium and Wolbachia, but the effects of these endosymbionts together or individually on the host microbiome and fecundity are unclear. Here, we established three S. furcifera lines (Cardinium and Wolbachia double-infected, Cardinium single-infected, and both-uninfected lines) backcrossed to a common nuclear background and found that single and double infections reduced bacterial diversity and changed bacterial community structure across nymph and adult stages and across adult tissues. The endosymbionts differed in densities between adults and nymphs as well as across adult tissues, with the distribution of Cardinium affected by Wolbachia. Both the single infection and particularly the double infection reduced host fecundity. Lines also differed in levels of metabolites, some of which may influence fecundity (e.g., arginine biosynthesis and nicotinamide metabolism). Cardinium in the single-infected line upregulated metabolic levels, while Wolbachia in the double-infected line appeared to mainly downregulate them. Association analysis pointed to possible connections between various bacteria and differential metabolites. These results reveal that Cardinium by itself and in combination with Wolbachia affect bacterial microbiota and levels of metabolites, with likely effects on host fecundity. Many of the effects of these metabolically limited endosymbionts that are dependent on the hosts may be exerted through manipulation of the microbiome. IMPORTANCE Endosymbionts can profoundly affect the nutrition, immunity, development, and reproduction of insect hosts, but the effects of multiple endosymbiont infections on microbiota and the interaction of these effects with insect host fitness are not well known. By establishing S. furcifera lines with different endosymbiont infection status, we found that Car

Published
2022

30. Corruption in Health Systems: The Conversation Has Started, Now Time to Continue it

Author

Lu, Hongsheng S., Ho, Bing X., and Miranda, J. Jaime

Subjects
Corruption, Peru, Commentary, Health Systems, Global Health
Abstract

Holistic and multi-disciplinary responses should be prioritized given the depth and breadth through which corruption in the healthcare sector can cover. Here, taking the Peruvian context as an example, we will reflect on the issue of corruption in health systems, including corruption with roots within and outside the health sector, and ongoing efforts to combat it. Our reflection of why corruption in health systems in settings with individual and systemic corruption should be an issue that is taken more seriously in Peru and beyond aligns with broader global health goals of improving health worldwide. Addressing corruption also serves as a pragmatic approach to health system strengthening and weakens a barrier to achieving universal health coverage and Sustainable Development Goals related to health and justice. Moreover, we will argue that by pushing towards a practice of normalizing the conversation about corruption in health has additional benefits, including expanding the problematization to a wider audience and therefore engaging with communities. For young researchers and global health professionals with interests in improving health systems in the early career stages, corruption in health systems is an issue that could move to the forefront of the list of global health challenges. This is a challenge that is uniquely multi-disciplinary, spanning the health, economy, and legal sectors, with wider societal implications.

Published
2019

31. Hypoxia-Inducible Factor-1α in Rods Is Neuroprotective Following Retinal Detachment

Author

Bing X, Ross, Lin, Jia, Dejuan, Kong, Tiantian, Wang, Jingyu, Yao, Heather M, Hager, Steven F, Abcouwer, and David N, Zacks

Subjects
Mice, Blotting, Western, Retinal Detachment, Animals, General Medicine, Hyaluronic Acid, Hypoxia, Hypoxia-Inducible Factor 1, alpha Subunit, Neuroprotection, Photoreceptor Cells, Vertebrate
Abstract

Following retinal detachment (RD) photoreceptors (PRs) sustain hypoxic stress and eventually die. Hypoxia-inducible factor-1α (HIF-1α) plays a central role in cellular adaptation to hypoxia. The purpose of this study is to determine the necessity of HIF-1α on PR cell survival after RD.Experimental RD was created in mice by injection of hyaluronic acid (1%) into the subretinal space. Mice with conditional HIF-1α knockout in rods (denoted as HIF-1αΔrod) were used. HIF-1α expression in retinas was measured real-time polymerase chain reaction (RT-PCR) and Western blotting. PR cell death after RD was evaluated using TUNEL assay. Optical coherence tomography (OCT) and histology were used to evaluate retinal layer thicknesses and PR cell densities. A hypoxia signaling pathway PCR array was used to examine the expression of HIF-1α target genes after RD.HIF-1α protein levels were significantly increased after RD, and depletion of HIF-1α in rods blunted this increase. A compensatory increase of HIF-2α protein was observed in HIF-1αΔrod mice. Conditional knockout (cKO) of HIF-1α in rods did not lead to any morphologic change in attached retinas but resulted in significantly increased PR cell loss after RD. HIF-1α cKO in rods altered the responses to retinal detachment for 25 out of 83 HIF-1α target genes that were highly enriched for genes involved in glycolysis.Rod-derived HIF-1α plays a key role in the PR response to RD, mediating the transcriptional activity of a battery of genes to promote PR cell survival.

Published
2022

33. Peptide-mediated cationic micelles drug-delivery system applied on a VEGFR3-overexpressed tumor

Author

Qi Y. Wang, Hong M. Li, Yue Wang, Bing X. Li, Tao Lu, Zhi P Dong, and Ming Huo

Subjects
Drug, Cell Survival, Polymers, media_common.quotation_subject, Biomedical Engineering, Mice, Nude, Antineoplastic Agents, Peptide, Pharmacology, Endocytosis, Micelle, Mice, Pharmacokinetics, Cations, Neoplasms, Animals, Humans, General Materials Science, Amino Acid Sequence, Micelles, media_common, chemistry.chemical_classification, Drug Carriers, General Chemistry, General Medicine, Vascular Endothelial Growth Factor Receptor-3, Rats, Drug Liberation, chemistry, A549 Cells, Doxorubicin, Drug delivery, Nanomedicine, Radiopharmaceuticals, Nanocarriers, Peptides, Half-Life
Abstract

Copolymers as a kind of drug delivery carrier always lack targeting efficiency. So a peptide conjugated to a drug delivery system has attracted much attention for tumor-targeted nanomedicine. Thus, we here report a conjugation compound consisting of a copolymer (PEG-b-PLL) and a peptide (Cys-Ile-Gln-Pro-Phe-Tyr-Pro, CP7). For receptor-mediated endocytosis by this peptide, the CP7-PEG-b-PLL conjugation significantly enhanced the chemotherapeutic efficacy as a potent nanocarrier compared with free DOX. The CP7-PEG-b-PLL exhibited excellent pharmacokinetic behavior via a radioactive iodine-131 (I) tracing method. With this, the CP7-PEG-b-PLL/DOX system showed better tumor growth inhibition when studied on A549 cell lines and subcutaneous tumor models, but with less toxicity than free DOX. All these results suggest that the CP7-modified drug cationic micelles could represent a novel platform for successful drug delivery toward VEGFR3-overexpressed tumors.

Published
2019

34. Self-management of depression among Chinese community individuals: A cross-sectional study using the transtheoretical model

Author

Shu F Jiao, Zhongchun Liu, Run Huang, Wen C Chen, Bing X Yang, Jie Chen, and Xiao Q Wang

Subjects
China, Self-management, 030504 nursing, Cross-sectional study, Depression, Self-Management, Perspective (graphical), Transtheoretical model, Context (language use), General Medicine, Mental health, Self Efficacy, 030227 psychiatry, 03 medical and health sciences, 0302 clinical medicine, Cross-Sectional Studies, Transtheoretical Model, Surveys and Questionnaires, Chinese community, Humans, Pshychiatric Mental Health, 0305 other medical science, Psychology, Depression (differential diagnoses), Clinical psychology
Abstract

Purpose To investigate the self-management of depression among members of a Chinese community. Design and methods A cross-sectional survey was conducted in Wuhan. The Depression Prevention and Management Survey was used to identify 429 participants' stage of change, perceived benefits, process of change and self-efficacy, based on the transtheoretical model perspective. Findings A majority of participants (69.0%) were at the inactive stage of depression self-management. The mean score of the process of change was 87.62 (SD = 24.83). ANOVA analysis showed gender, education, and family function were significant influencing factors in the process of change. Practice implications Mental health nurses need to target their approach to the level of the individual based on the transtheoretical model to assist them to enhance their awareness and motivation. More consideration should be given to gender, education, and family function in the context of depression self-management.

Published
2021

38. Loss of High-Mobility Group Box 1 (HMGB1) Protein in Rods Accelerates Rod Photoreceptor Degeneration After Retinal Detachment

Author

Steven F. Abcouwer, Jingyu Yao, Heather Hager, Joanne Choi, David N. Zacks, and Bing X Ross

Subjects
0301 basic medicine, Time Factors, genetic structures, chemical and pharmacologic phenomena, Retina, 03 medical and health sciences, chemistry.chemical_compound, retinal detachment, Mice, 0302 clinical medicine, Retinal Rod Photoreceptor Cells, Conditional gene knockout, medicine, Extracellular, Animals, HMGB1 Protein, Outer nuclear layer, mouse, HMGB1, medicine.diagnostic_test, biology, Chemistry, Retinal Degeneration, Retinal detachment, Retinal, medicine.disease, photoreceptor, Cell biology, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, Rhodopsin, biology.protein, sense organs, 030217 neurology & neurosurgery, Electroretinography
Abstract

Purpose Retinal detachment (RD) disrupts the nutritional support and oxygen delivery to photoreceptors (PRs), ultimately causing cell death. High-mobility group box 1 (HMGB1) can serve as an extracellular alarmin when released from stressed cells. PRs release HMGB1 after RD. The purpose of this study was to investigate the relationship between HMGB1 and PR survival after RD. Methods Acute RD was created by injection of hyaluronic acid (1%) into the subretinal space in C57BL/6 mice and mice with a rhodopsin-Cre-mediated conditional knockout (cKO) of HMGB1 in rods (HMGB1ΔRod). Immunofluorescence (IF) in retinal sections was used to localize HMGB1, rhodopsin, and Iba-1 proteins. Optical coherence tomography and electroretinography were used to quantify retinal thickness and function, respectively. The morphology of the retina was assessed by hematoxylin and eosin. Results HMGB1 protein was localized to the nuclei of all retinal neurons, including PRs, with cones staining more intensely than rods. HMGB1 protein was also found in the inner and outer segments of cones but not rods. Creation of RD caused a dramatic increase of HMGB1 protein IF in rods. cKO of HMGB1 in rods did not affect retinal structure or function. However, after RD, loss of rods and reduction in the thickness of the outer nuclear layer were significantly increased in the HMGB1ΔRod retinas as compared to the control. Interestingly, depletion of HMGB1 in rods did not affect the activation and mobilization of microglia/macrophages normally seen after RD. Conclusions Increased HMGB1 expression in stressed rods may represent an intrinsic mechanism regulating their survival after RD.

Published
2020

39. Corruption in Health Systems: The Conversation Has Started, Now Time to Continue it Comment on 'We Need to Talk About Corruption in Health Systems'

Author

Bing X Ho, J. Jaime Miranda, and Hongsheng S Lu

Subjects
Health (social science), Leadership and Management, Corruption, media_common.quotation_subject, 030231 tropical medicine, corruption, Global health, peru, global health, Context (language use), Management, Monitoring, Policy and Law, Economic Justice, 03 medical and health sciences, Health systems, 0302 clinical medicine, Health Information Management, career, purl.org/pe-repo/ocde/ford#3.03.02 [https], Political science, Peru, Health care, Conversation, human, 030212 general & internal medicine, 10. No inequality, purl.org/pe-repo/ocde/ford#3.03.01 [http], media_common, Sustainable development, sustainable development, business.industry, Health Policy, lcsh:Public aspects of medicine, article, lcsh:RA1-1270, Public relations, 16. Peace & justice, justice, Problematization, health insurance, conversation, business, health systems
Abstract

Holistic and multi-disciplinary responses should be prioritized given the depth and breadth through which corruption in the healthcare sector can cover. Here, taking the Peruvian context as an example, we will reflect on the issue of corruption in health systems, including corruption with roots within and outside the health sector, and ongoing efforts to combat it. Our reflection of why corruption in health systems in settings with individual and systemic corruption should be an issue that is taken more seriously in Peru and beyond aligns with broader global health goals of improving health worldwide. Addressing corruption also serves as a pragmatic approach to health system strengthening and weakens a barrier to achieving universal health coverage and Sustainable Development Goals related to health and justice. Moreover, we will argue that by pushing towards a practice of normalizing the conversation about corruption in health has additional benefits, including expanding the problematization to a wider audience and therefore engaging with communities. For young researchers and global health professionals with interests in improving health systems in the early career stages, corruption in health systems is an issue that could move to the forefront of the list of global health challenges. This is a challenge that is uniquely multi-disciplinary, spanning the health, economy, and legal sectors, with wider societal implications.

Published
2020

40. Recent infection by Wolbachia alters microbial communities in wild Laodelphax striatellus populations

Author

Duan, X-Z, Sun, J-T, Wang, L-T, Shu, X-H, Guo, Y, Keiichiro, M, Zhu, Y-X, Bing, X-L, Hoffmann, AA, Hong, X-Y, Duan, X-Z, Sun, J-T, Wang, L-T, Shu, X-H, Guo, Y, Keiichiro, M, Zhu, Y-X, Bing, X-L, Hoffmann, AA, and Hong, X-Y

Abstract

BACKGROUND: Host-associated microbial communities play an important role in the fitness of insect hosts. However, the factors shaping microbial communities in wild populations, including genetic background, ecological factors, and interactions among microbial species, remain largely unknown. RESULTS: Here, we surveyed microbial communities of the small brown planthopper (SBPH, Laodelphax striatellus) across 17 geographical populations in China and Japan by using 16S rRNA amplicon sequencing. Using structural equation models (SEM) and Mantel analyses, we show that variation in microbial community structure is likely associated with longitude, annual mean precipitation (Bio12), and mitochondrial DNA variation. However, a Wolbachia infection, which is spreading to northern populations of SBPH, seems to have a relatively greater role than abiotic factors in shaping microbial community structure, leading to sharp decreases in bacterial taxon diversity and abundance in host-associated microbial communities. Comparative RNA-Seq analyses between Wolbachia-infected and -uninfected strains indicate that the Wolbachia do not seem to alter the immune reaction of SBPH, although Wolbachia affected expression of metabolism genes. CONCLUSION: Together, our results identify potential factors and interactions among different microbial species in the microbial communities of SBPH, which can have effects on insect physiology, ecology, and evolution. Video Abstract.

Published
2020

41. Population genomic data in spider mites point to a role for local adaptation in shaping range shifts

Author

Chen, L, Sun, J-T, Jin, P-Y, Hoffmann, AA, Bing, X-L, Zhao, D-S, Xue, X-F, Hong, X-Y, Chen, L, Sun, J-T, Jin, P-Y, Hoffmann, AA, Bing, X-L, Zhao, D-S, Xue, X-F, and Hong, X-Y

Abstract

Local adaptation is particularly likely in invertebrate pests that typically have short generation times and large population sizes, but there are few studies on pest species investigating local adaptation and separating this process from contemporaneous and historical gene flow. Here, we use a population genomic approach to investigate evolutionary processes in the two most dominant spider mites in China, Tetranychus truncatus Ehara and Tetranychus pueraricola Ehara et Gotoh, which have wide distributions, short generation times, and large population sizes. We generated genome resequencing of 246 spider mites mostly from China, as well as Japan and Canada at a combined total depth of 3,133×. Based on demographic reconstruction, we found that both mite species likely originated from refugia in southwestern China and then spread to other regions, with the dominant T. truncatus spreading ~3,000 years later than T. pueraricola. Estimated changes in population sizes of the pests matched known periods of glaciation and reinforce the recent expansion of the dominant spider mites. T. truncatus showed a greater extent of local adaptation with more genes (76 vs. 17) associated with precipitation, including candidates involved in regulation of homeostasis of water and ions, signal transduction, and motor skills. In both species, many genes (135 in T. truncatus and 95 in T. pueraricola) also showed signatures of selection related to elevation, including G‐protein‐coupled receptors, cytochrome P450s, and ABC‐transporters. Our results point to historical expansion processes and climatic adaptation in these pests which could have contributed to their growing importance, particularly in the case of T. truncatus.

Published
2020

44. De Novo Computational Design for Development of a Peptide Ligand Oriented to VEGFR-3 with High Affinity and Long Circulation

Author

Li X. Liu, Tao Lu, Ming S. Lin, Yue Wang, Xiao N. Ma, Bing X. Li, Zhi P Dong, Hong M. Li, and Qi Y. Wang

Subjects
0301 basic medicine, Biodistribution, Cell, Fluorescent Antibody Technique, Pharmaceutical Science, Peptide, Kidney, Ligands, Mice, 03 medical and health sciences, In vivo, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Peptide library, Radioisotopes, chemistry.chemical_classification, A549 cell, Vascular Endothelial Growth Factor Receptor-3, Rats, 030104 developmental biology, medicine.anatomical_structure, chemistry, Biochemistry, A549 Cells, Drug delivery, Molecular Medicine, Female, Peptides, Immunostaining, HeLa Cells
Abstract

The overexpression of VEGFR-3 is correlated with a worse prognosis in lung cancer and has been regarded as a rational target for specific drug delivery. Here, VEGFR-3 homing peptide library was efficiently established by computational design. Strong fluorescent signals of selected peptides were observed in A549 cells, but much weaker in other cells. The positive immunostaining overlapped with VEGFR-3 confirmed high affinity and selectivity of one novel peptide (CP-7). In addition, cell uptake of FITC–CP-7 peptide was significantly blocked by coinjection of excess CP-7 peptide. After labeled with 131I, the profile of pharmacology and biodistribution could be traced in vivo. The 131I-radiolabeled CP-7 peptide conjugates were >85% stable in serum over 4 h and exhibited a specific uptake of 18.04 ± 2.04% ID/g at 0.5 h after injection to high VEGFR-3 expressing A549 tumor mice. More importantly, lower uptake concentration in heart (1.06 ± 0.15% ID/g) after 2 h demonstrated the safety of peptide in vivo. The hi...

Published
2017

45. IL-24 Promotes Pseudomonas aeruginosa Keratitis in C57BL/6 Mouse Corneas

Author

Nan Gao, Theodore J. Standiford, Jianjiang Xu, Fushin X Yu, Xinhan Cui, and Bing X. Ross

Subjects
musculoskeletal diseases, 0301 basic medicine, Pseudomonas aeruginosa, medicine.medical_treatment, Immunology, Biology, medicine.disease, medicine.disease_cause, Keratitis, Proinflammatory cytokine, Microbiology, Pathogenesis, 03 medical and health sciences, 030104 developmental biology, medicine.anatomical_structure, Cytokine, Osteoprotegerin, RANKL, medicine, biology.protein, Immunology and Allergy, Corneal epithelium
Abstract

The aim of this study was to elucidate the expression and functions of IL-17 in C57BL/6 mouse corneas in response to Pseudomonas aeruginosa infection. We found that P. aeruginosa infection induced and increased signaling of IL-23/23R/17/17R in mouse corneas. Targeting IL-17A or the IL-17A-specific receptor IL-17RA/IL-17RC with neutralizing Abs resulted in a significant decrease in the severity of P. aeruginosa keratitis, including a decrease in bacterial burden and polymorphonuclear leukocyte infiltration. IL-17A-signaling blockade also significantly reduced the expression of the proinflammatory cytokines L-1β, IL-24, and MMP-13 and increased the expression of the anti-inflammatory cytokine IL-1RA in mouse corneal epithelium. The presence of mouse IL-17A exacerbated P. aeruginosa-mediated tissue destruction. A cytokine protein array revealed that the expression of osteoprotegerin (OPG) was regulated by IL-17A, and OPG neutralization also resulted in a decrease in the severity of P. aeruginosa keratitis. Although both IL-17 and OPG affected the balanced expression of IL-1β and IL-1RA, only IL-17 inhibited the expression of TH2 cytokines. Taken together, our results revealed that IL-17A, along with its downstream factor OPG, plays a detrimental role in the pathogenesis of P. aeruginosa keratitis. Targeting IL-17A and/or the OPG/RANKL/RANK/TRAIL system is a potential therapeutic strategy in controlling the outcome of P. aeruginosa keratitis, which was demonstrated by concurrent topical application of IL-17A-neutralizing Ab and ciprofloxacin in B6 mice.

Published
2017

46. ISG15 in Host Defense Against Candida albicans Infection in a Mouse Model of Fungal Keratitis

Author

Nan Gao, Chen Dong, Fushin X Yu, and Bing X. Ross

Subjects
0301 basic medicine, ISG15, Blotting, Western, Enzyme-Linked Immunosorbent Assay, Biology, Real-Time Polymerase Chain Reaction, Keratitis, Microbiology, Cornea, 03 medical and health sciences, Mice, Candida albicans, medicine, Animals, Humans, Fungal keratitis, innate immunity, Ubiquitins, Cells, Cultured, Fungal genetics, Candidiasis, Eye infection, medicine.disease, biology.organism_classification, Immunohistochemistry, Corpus albicans, 3. Good health, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Gene Expression Regulation, TLR5, fungal keratitis, Cytokines, RNA, Female, Carrier Proteins, Eye Infections, Fungal
Abstract

Purpose ISG15, a di-ubiquitin-like protein, is critical for controlling certain viral and bacterial infections. We sought to determine if ISG15 plays a role in corneal innate immunity against Candida albicans (C. albicans) using a C57BL/6 (B6) mouse model of human fungal keratitis. Methods Scarified corneas of adult B6 mice were pretreated with TLR5 ligand flagellin and then inoculated with C. albicans. The expression of ISG15 and other genes involved in ISG15 conjugation (ISGylation) was determined by real-time PCR. ISG15 expression and distribution in infected corneas were assessed by immunohistochemistry. ISGylation was examined by Western blotting. siRNA knockdown and recombinant ISG15 were used to elucidate the effects of ISG15 on controlling fungal keratitis by clinical scoring, fungal number plate counting, ELISA cytokine determination, and polymorphonuclear leukocytes (PMN) infiltration measurement. Results Heat-killed C. albicans induced expression of ISG15, and hBD2 was markedly enhanced by flagellin-pretreatment in cultured human primary corneal epithelial cells (CECs). In vivo, C. albicans infection induced the expression of ISG15, ISGylation-associated genes (UBE1L, UBCH8, and HERC5), and ISGylation in mouse CECs, all of which were enhanced by flagellin-pretreatment. siRNA knockdown of ISG15 increased keratitis severity, dampened flagellin-induced protection, and greatly suppressed the expressions of ISGylation enzymes, IFN-γ, but not CXCL2 in B6 mouse CECs. Recombinant ISG15, on the other hand, enhanced corneal innate immunity against C. albicans and suppressed infection-induced IL-1β, but not IL-Ra expression. ISG15 alone induced the expression of IL-1Ra, CXCL10, and CRAMP in mouse CECs. ISG15 was upregulated and secreted in cultured human CECs in response to challenge in a type 1 IFN-dependent manner. Conclusions Our data, for the first time, demonstrate that ISG15 acts as an immunomodulator in the cornea and plays a critical role in controlling fungal keratitis.

Published
2017

47. Self‐management of depression among Chinese community individuals: A cross‐sectional study using the transtheoretical model.

Author

Huang, Run, Wang, Xiao Q., Yang, Bing X., Liu, Zhongchun, Chen, Wen C., Jiao, Shu F., and Chen, Jie

Subjects
CHINESE people, PSYCHOLOGY, ACQUISITION of data methodology, SELF-management (Psychology), CROSS-sectional method, ATTITUDE (Psychology), CHANGE, ONE-way analysis of variance, SELF-efficacy, SEX distribution, T-test (Statistics), MENTAL depression, TRANSTHEORETICAL model of change, MEDICAL records, DESCRIPTIVE statistics, RESEARCH funding, FAMILY relations, STATISTICAL sampling, DATA analysis software, BEHAVIOR modification, EDUCATIONAL attainment
Abstract

Purpose: To investigate the self‐management of depression among members of a Chinese community. Design and Methods: A cross‐sectional survey was conducted in Wuhan. The Depression Prevention and Management Survey was used to identify 429 participants' stage of change, perceived benefits, process of change and self‐efficacy, based on the transtheoretical model perspective. Findings: A majority of participants (69.0%) were at the inactive stage of depression self‐management. The mean score of the process of change was 87.62 (SD = 24.83). ANOVA analysis showed gender, education, and family function were significant influencing factors in the process of change. Practice Implications: Mental health nurses need to target their approach to the level of the individual based on the transtheoretical model to assist them to enhance their awareness and motivation. More consideration should be given to gender, education, and family function in the context of depression self‐management. [ABSTRACT FROM AUTHOR]

Published
2022
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48. Zebrafish DANA retroposon can form large zebrafish sequence in human Hepg2 and 293T cell lines

Author

Ding W, Jun Qiang, Cao Z, Bing X, and Pao Xu

Subjects
Expression vector, HEK 293 cells, Mutant, Retroposon, Primer walking, Coding region, Biology, biology.organism_classification, Genome, Molecular biology, Zebrafish
Abstract

In this study, we cloned small zebrafish retroposon DANA from zebrafish genome and constructed the lentiviral expression vector pEB-GFP (T2A)PURO. Three human cell lines including 293T, Hepg2 and LO2 were selected as infection targets. After detecting the expression of DANA, we found that the expression of DANA retroposon in three cells had different effects on cell lines through chromosome walking. Among these cells, LO2 showed no DANA retrotrans-position, while 293T and Hepg2 cell lines displayed retrotrans-position with the formation of some zebrafish genome fragments. Thereafter, we constructed a mutant of DANA retroposon and infected it in 293T cells, but no retrotrans-position was found after chromosome walking. Re-sequencing of the two cell lines (293T and Hepg2) showed that a large number of zebrafish genome fragments were found in the genomes of both cell lines, which could be divided into four types. The first type was zebrafish microsatellite sequence, accounting for 79.23% and 74.45% in 293T cell line and Hepg2 cell line, respectively. The second type was the sequence with a small amount of poly A or T, and the third type was the sequence with poly G or C, and the second and third types accounted very low proportion. The fourth type was composed of coding sequence and non-coding sequence, with large difference and very low proportion of common sequences between the two cell lines. Taken together, this study indicated that zebrafish DANA retroposon can result in retrotrans-position using the retrotrans system of human cell lines.

Published
2018

49. Rearranged zebrafish genomic DNA induces zebrafish mutant after microinjection into fertilized egg and preliminary study of the mechanism

Author

Jun Qiang, Ding W, Pao Xu, Bing X, and Cao Z

Subjects
Genetics, genomic DNA, biology, Regulatory sequence, Mutant, Sequence-specific DNA binding, Primer walking, Chromosome, biology.organism_classification, Zebrafish, Gene
Abstract

Genomic DNA of zebrafish was first digested incompletely with Msp I, and then the fragments were joined to form rearranged genomic DNA. This rearranged genomic DNA was incompletely digested with EcoR I, and the fragments were linked with a long adaptor. Two primers (Gmprimer1 and Gmprimer2) were designed according to the adaptor sequence for two-step amplification. The Gmprimer1-amplified products were microinjected into fertilized zebrafish eggs after purification and a red flesh mutant was observed among 42 surviving zebrafish. We obtained several introduced sequences by two-step amplification. The second set of Gmprimer2-amplified products were purified and microinjected into fertilized zebrafish eggs; all 37 surviving fish were red flesh mutants. We found that the largest amplified band from the mutant from the first microinjection was also present in the amplified pattern from six mutants from the second microinjection. The length of the sequence was 2,565 bp, but it did not encode any proteins. Microinjecting this sequence into fertilized zebrafish eggs produced the red flesh mutant. The sequences differed slightly among different individuals from the second microinjection. Most regions of these sequences were the same, with the exception of a hypervariable region. We mixed 10 such sequences equally and microinjected them into zebrafish zygotes; the findings showed that most zygotes died and the surviving zebrafish were almost all mutants. By genome walking, we found that the site of insertion of the fragment was the same, beginning at position 41,365,003 of the eighth chromosome, and that downstream of the introduced fragment is a conservative sequence of 6,536 bp (named Cao-sequence), starting from a small reverse repeat sequence, not encoding any gene, nor similar to any known regulatory sequence. It has 322 homologous sequences in the zebrafish genome, which are distributed in all chromosomes. We designed two primers within Cao-sequence and several primers specific for different locations upstream of it. Compared with normal zebrafish, we found that the amplified patterns of all mutants in Cao-sequence regions changed to varying degrees. To further understand the effect of the introduced sequence on the zebrafish genomes, we selected six mutants for whole-genome resequencing. The results showed that numerous Cao-sequences from these six mutants were partially deleted and the lengths of the deletions was mostly approximately 6,100 bp, being located at the 5′ end of Cao-sequences. Among them, 43 Cao-sequence loci were commonly deleted from the six mutants (with slightly different locations), and the other deletion sites were not identical. We think that different deletion combinations of Cao-sequence may show different mutation characteristics. The tail part from four red flesh mutants and three individuals of wild type were collected for transcriptome sequencing. TopGO analysis showed that the 4 most significant enrichment nodes were sequence specific DNA binding proteins, sequence specific transcription factors, chromatin proteins and zinc binding proteins. The results of KEGG enrichment analysis showed that the top four affected KEGG-pathways were metabolic pathways, oxidative phosphorylation, citrate cycle and 2-oxocarboxylic acid metabolism.We conclude that deletion of Cao-sequence can affect the expression of a series of transcription regulators and specific DNA binding proteins, then many basic metabolic processes were disturbed which led to mutations.

Published
2018
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50. Vitreous Cytokine Expression and a Murine Model Suggest a Key Role of Microglia in the Inflammatory Response to Retinal Detachment

Author

Bing X Ross, David N. Zacks, Jingyu Yao, Chris Andrews, Lee Kiang, Sumathi Shanmugam, Sean Hansen, Steven F. Abcouwer, and Cagri G. Besirli

Subjects
0301 basic medicine, Male, medicine.medical_specialty, genetic structures, leukocytes, medicine.medical_treatment, Vitrectomy, Real-Time Polymerase Chain Reaction, Retina, 03 medical and health sciences, Mice, 0302 clinical medicine, Ophthalmology, medicine, Animals, Humans, CX3CL1, Retinal pigment epithelium, business.industry, Retinal Detachment, Retinal detachment, General Medicine, Middle Aged, medicine.disease, Flow Cytometry, eye diseases, Immunity, Innate, CXCL1, Vitreous Body, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, Cytokine, Gene Expression Regulation, inflammation, 030221 ophthalmology & optometry, Cytokines, RNA, Female, sense organs, Microglia, Epiretinal membrane, business
Abstract

Purpose Retinal detachment (RD) separates the retina from the underlying retinal pigment epithelium, resulting in a gradual degeneration of photoreceptor (PR) cells. It is known that RD also results in an inflammatory response, but its contribution to PR degeneration is unknown. In this study we examine the inflammatory responses to RD in patient vitreous and validate a mouse experimental RD as a model of this phenomenon. Methods Multiplex bead arrays were used to examine cytokine levels in vitreous samples from 24 patients with macula-off rhegmatogenous retinal detachment (RRD) undergoing reattachment surgery and from 10 control patients undergoing vitrectomy for vitreous opacities or epiretinal membrane. Activation of the innate immune response was then examined in a mouse model of RD. Results Twenty-eight factors were significantly increased in vitreous from RD patients versus controls. Notable were the cytokines MCP-1 (CCL2), IP-10 (CXCL10), fractalkine (CX3CL1), GRO (CXCL1), MDC (CCL22), IL-6, and IL-8, which all exhibited relatively high concentrations and several-fold increases in the vitreous of RD patients. Concentrations of various analytes correlated with a range of clinical variables such as duration of detachment and visual acuity. Retinal detachment in the mouse resulted in cytokine mRNA expression changes consistent with human RD vitreous results, as well as microglial proliferation and migration toward the outer retina. Conclusions The findings suggest that an inflammatory response involving microglia is a component of the reaction to retinal detachment that may impact visual acuity after surgical repair and that mouse experimental RD can serve as a model to study this effect.

Published
2018

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