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10. Suppression of luminescence quenching at the nanometer scale in Gd2O3 doped with Eu3+ or Tb3+: Systematic comparison between nanometric and macroscopic samples of life-time, quantum yield, radiative and non-radiative decay rates.

Author

Mutelet, B., Perriat, P., Ledoux, G., Amans, D., Lux, F., Tillement, O., Billotey, C., Janier, M., Villiers, C., Bazzi, R., Roux, S., Lu, G., Gong, Q., and Martini, M.

Subjects
LUMINESCENCE, OPTICAL properties, NANOSTRUCTURED materials, GADOLINIUM, OXIDES, QUANTUM theory
Abstract

By systematically studying the evolution of the optical properties with the content of some doping elements (Eu and Tb) in cubic gadolinium oxide, we demonstrated that the luminescence quenching could be almost entirely suppressed by elaboration of the samples in the nanometer range. Indeed, even if the proportion of quenchers (here surface hydroxyl groups) does increase at this scale, each rare-earth cation possesses an electronic configuration that depends on its distance from the surface and then slightly differs from that of the surrounding atoms. This difference almost eliminates any resonant transfer of excitation between all the atoms within the particle and suppresses a significant proportion of non-radiative losses. As a consequence, the quantum yield is not affected by the phenomenon of luminescence quenching because of concentration that is usually encountered in macroscopic samples. The emission can then be increased by a factor of about 3 for Tb and 5 for Eu simply by increasing the doping content. Moreover, the lifetime is significantly increased compared to macroscopic samples and, contrary to what happens at the macroscopic scale, does not depend on the doping content. This result opens new strategies to increase the emission of many fluorophores already commercialized, provided that the bcc structure is effectively preserved in the desired application. [ABSTRACT FROM AUTHOR]

Published
2011
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11. Gadolinium based nanoparticles for radiosensitization of head and neck squamous cell carcinoma

Author

Rodriguez-Lafrasse, C., T Aloy, M., Miladi, I., Armandy, E., Sancey, L., Aurélie Berniard, Billotey, C., Tillement, O., Lux, F., Perriat, P., Marc Janier, Ciblage thérapeutique en Oncologie (EA3738), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Institut Lumière Matière [Villeurbanne] (ILM), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Matériaux, ingénierie et science [Villeurbanne] (MATEIS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), and Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS]Physics [physics]
Abstract

International audience; Purpose: Head and neck squamous cell carcinoma (HNSCC) is an aggressive and recurrent malignancy that displays intrinsic resistance to radio- and chemotherapy. The aim of this study is to radiosensitize these tumors using gadolinium based nanoparticles (GBN) made of a polysiloxane matrix and surrounded by gadolinium chelates. The nanoparticles in the tumors should enhance the efficacy of radiotherapy (thanks to the high Z of gadolinium) through the generation of electron Auger cascade and secondary electrons.

Published
2014

12. Challenges of combining gadolinium-based nanoparticles with low- and high-LET radiation IN THE treatment of head and neck squamous cell carcinoma

Author

T Aloy, M., Miladi, I., Armandy, E., Mowat, P., Rima, W., Berniard, A., Billotey, C., Olivier Tillement, François Lux, Perriat, P., Marc Janier, Rodriguez-Lafrasse, C., Ciblage thérapeutique en Oncologie (EA3738), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Laboratoire de Physico-Chimie des Matériaux Luminescents (LPCML), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Institut Lumière Matière [Villeurbanne] (ILM), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Matériaux, ingénierie et science [Villeurbanne] (MATEIS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Ciblage thérapeutique en Oncologie ( EA3738 ), Université Claude Bernard Lyon 1 ( UCBL ), Laboratoire de Physico-Chimie des Matériaux Luminescents ( LPCML ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), Matériaux, ingénierie et science [Villeurbanne] ( MATEIS ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ) -Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ), Centre Hospitalier Lyon Sud [CHU - HCL] ( CHLS ), Hospices Civils de Lyon ( HCL ), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)

Subjects
[PHYS]Physics [physics], stomatognathic diseases, InformationSystems_MODELSANDPRINCIPLES, ComputingMilieux_THECOMPUTINGPROFESSION, GeneralLiterature_INTRODUCTORYANDSURVEY, health care facilities, manpower, and services, education, ComputingMilieux_COMPUTERSANDEDUCATION, ComputingMilieux_MISCELLANEOUS, health care economics and organizations
Abstract

Communication orale; International audience

Published
2013

13. Gadolinium based nanoparticles as radiosensitizing agents for radioresistant head and neck tumours

Author

Miladi , I., Aloy , M.-T., Berniard , A., Armandy , E., Mowat , P., Benchaib , M., Magne , M., Noirault , E., Billotey , C., Perriat , P., Lux , F., Tillement , O., Rodriguez-Lafrasse , C., Janier , M., Laboratoire de Physico-Chimie des Matériaux Luminescents (LPCML), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Ciblage thérapeutique en Oncologie (EA3738), Université de Lyon-Université de Lyon, Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Imagerie Moléculaire et Thérapie Vectorisée (IMTV), ITMO ' Technologies pour la Santé '-Cancéropôle CLARA-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université d'Auvergne - Clermont-Ferrand I (UdA), Laboratoire de Physico-Chimie des Matériaux Luminescents ( LPCML ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), Ciblage thérapeutique en Oncologie ( EA3738 ), Centre Hospitalier Lyon Sud [CHU - HCL] ( CHLS ), Hospices Civils de Lyon ( HCL ), Imagerie Moléculaire et Thérapie Vectorisée ( IMTV ), Université d'Auvergne - Clermont-Ferrand I ( UdA ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Cancéropôle CLARA-ITMO ' Technologies pour la Santé ', Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Cancéropôle CLARA-ITMO ' Technologies pour la Santé '

Subjects
[SDV]Life Sciences [q-bio], [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [CHIM]Chemical Sciences, [SDV.CAN]Life Sciences [q-bio]/Cancer, ComputingMilieux_MISCELLANEOUS
Abstract

International audience; Radiotherapy is one of the main therapies for cancer, but it remains limited when tumours are radioresistant such glioblastoma, head and neck tumours, osteo and chondrosarcomas for example. Several strategies aiming at radiosensitizing these resistant tumours are under development. One of those relies on the use of high density nanoparticles, which once delivered into the tumour should deliver secondary radiations amplifying the radiotherapy efficiency. A previous reported study from our consortium showed that Gadolinium Based Nanoparticles (GBN) were able to induce a clonogenic death of SQ20B cells in culture (human head and neck carcinoma cells). The present study aimed at the demonstration of the in-vivo radiosensitizing effect of these GBN on SQ20B xenograft tumour. Radiation Therapy (RT) was performed using a biological X-Ray Irradiator (X-RAD 320) (Byfleet, Surrey) with 320 KV X-rays. The field of irradiation was adapted according to tumor volume by using an adjustable collimator positioned 35 cm from the animals. The dose rate was of 2 Gy.min-1. Four/five weeks after tumor grafting, mice with tumor volume less than 400 mm3 were randomly selected for radiotherapy 5 minutes after intratumoral (IT) injection of either GBN or saline. Four groups of rats were compared: IT injection of saline only (Control) (n = 9), GBN IT injection only (GBN injection) (n = 9), IT injection of saline + 10 Gy radiation (IR 10Gy) (n = 13), and IT injection of GBN + 10 Gy (IR 10Gy + GBN) (n = 10). Compared to the progressive and massive increase in tumor volume observed in the control groups (control and GBN injection groups), 10 Gy radiation stabilized tumor evolution between the second and the third week after radiation. The tumors then started to develop again with a growth curve similar to that of the control group. In contrast, the combination of GBN with 10 Gy radiation limited spectacularly the SQ20B tumors growth. At the end of week 6, the mean reduction in tumor volume in the IR 10Gy + GBN group, was of 626 and 388% (P = 0,003) compared, respectively, to the control and only irradiated tumors. Moreover, in the end of our therapy study, tumors have disappeared in two mice given 10 Gy with GBN treatment. Combined with the in-vitro study, the reported results demonstrate a major radiosensitizing effect of Gadolinium Based Nanoparticles on radioresistant tumours such as Head and Neck carcinomas.

Published
2012

14. In vivo biodistribution of hybrid gadolinium oxide nanoparticles as multimodal imaging agent 7ème journée CLARA

Author

Taleb, J., Kryza, David, Janier, M., Mowat, P., Louis, C., Marmuse, L., Roux, S., Perriat, P., Tillement, O., Billotey, C., Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213) (UTINAM), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), and Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)

Subjects
[SDV]Life Sciences [q-bio]
Published
2011

15. F-18-FLT and F-18-FDG positron emission tomography for the imaging of advanced well-differentiated gastro-entero-pancreatic endocrine tumours

Author

Giammarile, F., Billotey, C., Lombard-Bohas, C., Le Bars, D., Bournaud, C., Masson, S., Walter, T., Houzard, C., J-Y, Scoazec, Hervieu, V., Jp. Vuillez, Catherine Cornu, Marc Janier, Borson-Chazot, F., Evaluation et modélisation des effets thérapeutiques, Département biostatistiques et modélisation pour la santé et l'environnement [LBBE], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), and Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV]Life Sciences [q-bio]
Published
2011

16. In vivo biodistribution of hybrid gadolinium oxide nanoparticles as multimodal imaging agent

Author

Taleb, J., Kryza, David, Janier, M., Mowat, P., Louis, C., Marmuse, L., Roux, S., Perriat, P., Tillement, O., Billotey, C., Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213) (UTINAM), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), and Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2011

17. Nanoparticle containing rare earth ions: A tunable tool for MRI

Author

Rivière, C., Roux, S., Bazzi, R., Bridot, J.-L., Billotey, C., Perriat, P., Tillement, O., Laboratoire de Physique de la Matière Condensée et Nanostructures (LPMCN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213) (UTINAM), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratoire de Physico-Chimie des Matériaux Luminescents (LPCML), Physicochimie des Electrolytes, Colloïdes et Sciences Analytiques (PECSA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Mons-Hainaut, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Groupe d'Etudes de Métallurgie Physique et Physique des Matériaux (GEMPPM), Institut National des Sciences Appliquées de Lyon (INSA Lyon), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[CHIM]Chemical Sciences
Published
2011

18. Nanoparticules multifonctionnelles pour des applications biomédicales - 6ème journée CLARA

Author

Faure, A.C., Dufort, S., Couleaud, P., Josserand, V., Frochot, C., Vanderesse, R., Billotey, C., Perriat, P., Coll, J.L., Roux, S., Tillement, O., Laboratoire de Physico-Chimie des Matériaux Luminescents (LPCML), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Chimie Physique Macromoléculaire (LCPM), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213) (UTINAM), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), and Debray, Bernard

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences
Published
2010

19. Validation of a dendron concept to tune colloidal stability, MRI relaxivity and bioelimination of functional nanoparticles

Author

Walter, A., primary, Garofalo, A., additional, Parat, A., additional, Jouhannaud, J., additional, Pourroy, G., additional, Voirin, E., additional, Laurent, S., additional, Bonazza, P., additional, Taleb, J., additional, Billotey, C., additional, Vander Elst, L., additional, Muller, R. N., additional, Begin-Colin, S., additional, and Felder-Flesch, D., additional

Published
2015
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20. Multifunctional gadolinium oxide nanoparticles: towards image-guided therapy

Author

Roux, S., C Mandon, A., Dufort, S., Riviere, C., L Bridot, J., Mutelet, B., Marquette, C. A., Josserand, V., Le Duc, G., Le Pape, A., Billotey, C., Marc Janier, L Coll, J., Perriat, P., Tillement, O., Département Economie et Sociologie des Transports ( INRETS/DEST ), Institut National de Recherche sur les Transports et leur Sécurité ( INRETS ), Institut de Chimie et Biochimie Moléculaires et Supramoléculaires ( ICBMS ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physico-Chimie des Matériaux Luminescents ( LPCML ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), Département Economie et Sociologie des Transports (INRETS/DEST), Institut National de Recherche sur les Transports et leur Sécurité (INRETS), Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physico-Chimie des Matériaux Luminescents (LPCML), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, and Depierre, Frédérique

Subjects
[ SDV.BBM.BC ] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM], [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2010

21. Hybrid nanosound for a multimodal imagery monitoring of cells in cancerology

Author

Billotey, C., Mandon, C., Marc Janier, Roux, S., Tillement, O., Penlou, S., Perriat, P., Garinot, M., Louis, C., Villiers, C., M Madec, A., Thivoler, C., Berard, F., Mateis, Laboratoire, Centre de Recherche et d'Application en Traitement de l'Image et du Signal (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Supérieure de Chimie Physique Électronique de Lyon (CPE)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de génétique et de physiologie moléculaire et cellulaire (CGPhiMC), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Laboratoire de psychologie sociale et de psychologie cognitive (LAPSCO), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physico-Chimie des Matériaux Luminescents (LPCML), Matériaux, ingénierie et science [Villeurbanne] (MATEIS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Institute of Molecular Biology and Biotechnology (IMBB-FORTH), Foundation for Research and Technology - Hellas (FORTH), Department of Biology, University of Crete [Heraklion] (UOC), Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Immunité infection vaccination (I2V), Université de Lyon-Université de Lyon-IFR128-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Centre National de la Recherche Scientifique (CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Institut National de la Santé et de la Recherche Médicale (INSERM)-EFS-CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF), and Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR128-Université Claude Bernard Lyon 1 (UCBL)

Subjects
[SPI.MAT] Engineering Sciences [physics]/Materials, ComputingMilieux_MISCELLANEOUS, [SPI.MAT]Engineering Sciences [physics]/Materials
Abstract

International audience

Published
2008

22. Nanosystems for medical applications: Biological detection, drug delivery, diagnosis and therapy

Author

Riviere, A., Roux, Philippe, Tillement, Olivier, Billotey, C., Perriat, Pascal, Matériaux, ingénierie et science [Villeurbanne] (MATEIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), and Mateis, Laboratoire

Subjects
[SPI.MAT] Engineering Sciences [physics]/Materials, [SPI.MAT]Engineering Sciences [physics]/Materials
Abstract

National audience; A review. For a couple of decades, greater and greater connections have been made between nanotechnology, biology and medicine. After a rapid description of the particles most often used for biological and medical purposes, the review will detail their potential applications in both domains. In the field of biological detection, a large number of new detection systems is offered by noble metals and semi-conductors, which exhibit very specific nanometre-scale induced properties. In the field of diagnosis and therapeutic applications, particles become more and more sophisticated with an increased possibility of specific targeting, drug delivery triggering and combination of both diagnosis and therapy.

Published
2006

34. CMR 2007: 7.07: Hybrid gadolinium oxide nanoparticles: contrast agents combining diagnosis and therapy

Author

Bridot, J.-L., primary, Dayde, D., additional, Faure, A.-C., additional, Laurent, S., additional, Rivière, C., additional, Billotey, C., additional, Hiba, B., additional, Janier, M., additional, Josserand, V., additional, Coll, J.-L., additional, Vander Elst, L., additional, Muller, R., additional, Sabattier, R., additional, Lerondel, S., additional, Lepape, A., additional, Perriat, P., additional, Roux, S., additional, and Tillement, O., additional

Published
2007
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38. Design of Gold Nanoparticles for Magnetic Resonance Imaging

Author

Debouttière, P.-J., primary, Roux, S., additional, Vocanson, F., additional, Billotey, C., additional, Beuf, O., additional, Favre-Réguillon, A., additional, Lin, Y., additional, Pellet-Rostaing, S., additional, Lamartine, R., additional, Perriat, P., additional, and Tillement, O., additional

Published
2006
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48. Successful surgical removal of occult metastases of medullary thyroid carcinoma recurrences with the help of immunoscintigraphy and radioimmunoguided surgery

Author

Labriolle-Vaylet, C., Cattan, P., Sarfati, E., Wioland, M., Billotey, C., Brocheriou, C., Rouvier, E., Roquancourt, A., Rostene, W., Askienazy, S., Jacques Barbet, Milhaud, G., and Gruaz-Guyon, A.

Subjects
Adult, Calcitonin, Male, Reproducibility of Results, Middle Aged, Sensitivity and Specificity, Carcinoembryonic Antigen, Radioimmunodetection, Recurrence, Carcinoma, Medullary, Lymphatic Metastasis, Humans, False Positive Reactions, Female, Thyroid Neoplasms, Neoplasm Metastasis, False Negative Reactions, Aged
Abstract

Patients with recurrent or metastatic medullary thyroid carcinoma (MTC) were referred for pretargeted immunoscintigraphy (Affinity Enhancement System; AES) and radioimmunoguided surgery (RIGS). Data collected from 13 patients establish that whole-body AES immunoscintigraphy revealed metastases360 mg and RIGS detected micrometastases (5-15 mg). All tissue samples removed by the surgeon were diagnosed by histology and immunohistochemistry of calcitonin to check the accuracy of IS and RIGS results. AES immunoscintigraphy is very sensitive. Of 34 metastases or recurrences detected, 22 had escaped physical examination or conventional imaging. The accuracy of RIGS was 86%, its sensitivity 75%, and its specificity was 90% (n = 208). IS and RIGS detected occult tumors that would have escaped surgery, clearly demonstrating clinical benefit. Serum calcitonin (normal, 10 pg/ml) and carcinoembryonic antigen (normal, 5 ng/ml) of two patients were restored to normal. In patients whose tumors were discovered, progression of their disease was slowed, as evidenced by the large decrease in serum calcitonin and carcinoembryonic antigen, an important prognostic factor. Surgery was canceled in one case where IS detected distant metastases out of surgical reach. Thus, AES immunoscintigraphy and RIGS might be of valuable help for the surgical management of medullary thyroid carcinoma.

49. T-Cell Homing to the Pancreas in Autoimmune Mouse Models of Diabetes: In Vivo MR Imaging

Author

Billotey, C., Aspord, C., Marc Janier, Beuf, O., Gazeau, F., Thivolet, C., Centre de Recherche et d'Application en Traitement de l'Image et du Signal (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Laboratoire Creatis, Compte Général

Subjects
[SDV.IB] Life Sciences [q-bio]/Bioengineering, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], [SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph], [PHYS.PHYS.PHYS-MED-PH] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, [SPI.OPTI] Engineering Sciences [physics]/Optics / Photonic, [INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [SPI.ELEC] Engineering Sciences [physics]/Electromagnetism, [INFO.INFO-IM] Computer Science [cs]/Medical Imaging, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], [SPI.ELEC]Engineering Sciences [physics]/Electromagnetism, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, [INFO.INFO-TI] Computer Science [cs]/Image Processing [eess.IV], [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [SDV.IB]Life Sciences [q-bio]/Bioengineering, [PHYS.MECA.ACOU] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, [SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing
Abstract

article

50. Assembly of Poly(vinylphosphonic acid)-Based Double Hydrophilic Block Copolymers by Gadolinium Ions for the Formation of Highly Stable MRI Contrast Agents.

Author

Markiewicz KH, Marmuse L, Mounsamy M, Billotey C, Destarac M, Mingotaud C, and Marty JD

Subjects
Rats, Animals, Polymers, Magnetic Resonance Imaging methods, Contrast Media, Gadolinium
Abstract

Mixing double-hydrophilic block copolymers containing a poly(vinylphosphonic acid) block with gadolinium ions in water leads to the spontaneous formation of polymeric nanoparticles. With an average diameter near 20 nm, the nanoparticles are stable after dilution or change of pH and ionic strength. High magnetic relaxivities were measured in vitro, and in vivo magnetic resonance imaging on rats demonstrates the high potential of such polymeric assemblies.

Published
2022
Full Text
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