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138 results on '"Billiet, Thibo"'

8. Longitudinal Brain Volume Findings in an Outpatient Practice of Young People with MS (P11-3.001)

Author

O’Neill, Kimberly, primary, Couvreur, Laura, additional, Hu, Jiyuan, additional, Zhang, Yan, additional, Pehel, Shayna, additional, Sosa, Anna, additional, Fade, Djemo, additional, Feld, Elayne, additional, Chen, Jingyun, additional, Barros, Nuno, additional, Billiet, Thibo, additional, Ribbens, Annemie, additional, and Krupp, Lauren, additional

Published
2023
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9. AI-based characterization of multiple sclerosis clinical symptomatology using lesion parenchymal fraction: empirical support for the topographical model of MS (P3-3.018)

Author

Krieger, Stephen, primary, Billiet, Thibo, additional, Maes, Celine, additional, De Barros, Nuno, additional, Van Hecke, Wim, additional, Ribbens, Annemie, additional, Wang, Tim, additional, Kyle, Kain, additional, Ly, Linda, additional, Garber, Justin, additional, and Barnett, Michael, additional

Published
2023
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12. Selective vulnerability of brainstem and cervical spinal cord regions in people with non-progressive multiple sclerosis of Black or African American and European ancestry

Author

Okuda, Darin T, primary, Stanley, Thomas, additional, McCreary, Morgan, additional, Smith, Alexander, additional, Wilson, Andrew, additional, Pinho, Marco C, additional, Yu, Fang F, additional, Billiet, Thibo, additional, Van Hecke, Wim, additional, Ribbens, Annemie, additional, Zeydan, Burcu, additional, Kantarci, Orhun, additional, Guo, Xiaohu, additional, and Moog, Tatum M, additional

Published
2022
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14. Myelin water fraction in relation to fractional anisotropy and reading in 10-year-old children

Author

UCL - SSH/IPSY - Psychological Sciences Research Institute, UCL - SSS/IONS - Institute of NeuroScience, Economou, Maria, Billiet, Thibo, Wouters, Jan, Ghesquière, Pol, Vanderauwera, Jolijn, Vandermosten, Maaike, UCL - SSH/IPSY - Psychological Sciences Research Institute, UCL - SSS/IONS - Institute of NeuroScience, Economou, Maria, Billiet, Thibo, Wouters, Jan, Ghesquière, Pol, Vanderauwera, Jolijn, and Vandermosten, Maaike

Abstract

Diffusion-weighted imaging studies have repeatedly shown that white matter correlates with reading throughout development. However, the neurobiological interpretation of this relationship is constrained by the limited microstructural specificity of diffusion imaging. A critical component of white matter microstructure is myelin, which can be investigated noninvasively using MRI. Here, we examined the link between myelin water fraction (MWF) and reading ability in 10-year-old children (n = 69). To better understand this relationship, we additionally investigated how these two variables relate to fractional anisotropy (FA; a common index of diffusion-weighted imaging). Our analysis revealed that lower MWF coheres with better reading scores in left-hemispheric tracts relevant for reading. While we replicated previous reports on a positive relationship between FA and MWF, we did not find any evidence for an association between reading and FA. Together, these findings contrast previous research suggesting that poor reading abilities might be rooted in lower myelination and emphasize the need for further longitudinal research to understand how this relationship evolves throughout reading development. Altogether, this study contributes important insights into the role of myelin-related processes in the relationship between reading and white matter structure.

Published
2022

15. Selective vulnerability of brainstem and cervical spinal cord regions in people with non-progressive multiple sclerosis of Black or African American and European ancestry.

Author

Okuda, Darin T, Stanley, Thomas, McCreary, Morgan, Smith, Alexander, Wilson, Andrew, Pinho, Marco C, Yu, Fang F, Billiet, Thibo, Van Hecke, Wim, Ribbens, Annemie, Zeydan, Burcu, Kantarci, Orhun, Guo, Xiaohu, and Moog, Tatum M

Subjects
CERVICAL cord, SPINAL cord, MULTIPLE sclerosis, AFRICAN Americans, BRAIN stem, PENIS curvatures
Abstract

Background: We evaluated imaging features suggestive of neurodegeneration within the brainstem and upper cervical spinal cord (UCSC) in non-progressive multiple sclerosis (MS). Methods: Standardized 3-Tesla three-dimensional brain magnetic resonance imaging (MRI) studies were prospectively acquired. Rates of change in volume, surface texture, curvature were quantified at the pons and medulla-UCSC. Whole and regional brain volumes and T2-weighted lesion volumes were also quantified. Independent regression models were constructed to evaluate differences between those of Black or African ancestry (B/AA) and European ancestry (EA) with non-progressive MS. Results: 209 people with MS (pwMS) having at least two MRI studies, 29% possessing 3–6 timepoints, resulted in 487 scans for analysis. Median follow-up time between MRI timepoints was 1.33 (25th–75th percentile: 0.51–1.98) years. Of 183 non-progressive pwMS, 88 and 95 self-reported being B/AA and EA, respectively. Non-progressive pwMS demonstrated greater rates of decline in pontine volume (p < 0.0001) in B/AA and in medulla-UCSC volume (p < 0.0001) for EA pwMS. Longitudinal surface texture and curvature changes suggesting reduced tissue integrity were observed at the ventral medulla-UCSC (p < 0.001), dorsal pons (p < 0.0001) and dorsal medulla (p < 0.0001) but not the ventral pons (p = 0.92) between groups. Conclusions: Selectively vulnerable regions within the brainstem-UCSC may allow for more personalized approaches to disease surveillance and management. [ABSTRACT FROM AUTHOR]

Published
2023
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16. sj-docx-2-msj-10.1177_13524585221139575 – Supplemental material for Selective vulnerability of brainstem and cervical spinal cord regions in people with non-progressive multiple sclerosis of Black or African American and European ancestry

Author

Okuda, Darin T, Stanley, Thomas, McCreary, Morgan, Smith, Alexander, Wilson, Andrew, Pinho, Marco C, Yu, Fang F, Billiet, Thibo, Van Hecke, Wim, Ribbens, Annemie, Zeydan, Burcu, Kantarci, Orhun, Guo, Xiaohu, and Moog, Tatum M

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-2-msj-10.1177_13524585221139575 for Selective vulnerability of brainstem and cervical spinal cord regions in people with non-progressive multiple sclerosis of Black or African American and European ancestry by Darin T Okuda, Thomas Stanley, Morgan McCreary, Alexander Smith, Andrew Wilson, Marco C Pinho, Fang F Yu, Thibo Billiet, Wim Van Hecke, Annemie Ribbens, Burcu Zeydan, Orhun Kantarci, Xiaohu Guo and Tatum M Moog in Multiple Sclerosis Journal

Published
2022
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17. sj-docx-1-msj-10.1177_13524585221139575 – Supplemental material for Selective vulnerability of brainstem and cervical spinal cord regions in people with non-progressive multiple sclerosis of Black or African American and European ancestry

Author

Okuda, Darin T, Stanley, Thomas, McCreary, Morgan, Smith, Alexander, Wilson, Andrew, Pinho, Marco C, Yu, Fang F, Billiet, Thibo, Van Hecke, Wim, Ribbens, Annemie, Zeydan, Burcu, Kantarci, Orhun, Guo, Xiaohu, and Moog, Tatum M

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-msj-10.1177_13524585221139575 for Selective vulnerability of brainstem and cervical spinal cord regions in people with non-progressive multiple sclerosis of Black or African American and European ancestry by Darin T Okuda, Thomas Stanley, Morgan McCreary, Alexander Smith, Andrew Wilson, Marco C Pinho, Fang F Yu, Thibo Billiet, Wim Van Hecke, Annemie Ribbens, Burcu Zeydan, Orhun Kantarci, Xiaohu Guo and Tatum M Moog in Multiple Sclerosis Journal

Published
2022
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22. Diffusion tensor imaging of the anterior cruciate ligament following primary repair with internal bracing: A longitudinal study

Author

Highfield Research Group, Regenerative Medicine and Stem Cells, Cancer, Van Dyck, Pieter, Froeling, Martijn, Heusdens, Christiaan H W, Sijbers, Jan, Ribbens, Annemie, Billiet, Thibo, Highfield Research Group, Regenerative Medicine and Stem Cells, Cancer, Van Dyck, Pieter, Froeling, Martijn, Heusdens, Christiaan H W, Sijbers, Jan, Ribbens, Annemie, and Billiet, Thibo

Published
2021

24. Le génotype des antigènes leucocytaires humains comme marqueur de l'évolution de l'état de santé de patients atteints de sclérose en plaques

Author

Lysandropoulos, Andreas, Perrotta, Gaetano, Billiet, Thibo, Ribbens, Annemie, Du Pasquier, Renaud, Pot Kreis, Caroline, Maggi, Pietro, Théaudin, Marie, Lysandropoulos, Andreas, Perrotta, Gaetano, Billiet, Thibo, Ribbens, Annemie, Du Pasquier, Renaud, Pot Kreis, Caroline, Maggi, Pietro, and Théaudin, Marie

Abstract

Objective: In a previous pilot monocentric study, we investigated the relation between human leukocyte antigen (HLA) genotype and multiple sclerosis (MS) disease progression over 2 years. HLA-A∗02 allele was correlated with better outcomes, whereas HLA-B∗07 and HLA-B∗44 were correlated with worse outcomes. The objective of this extension study was to further investigate the possible association of HLA genotype with disease status and progression in MS as measured by sensitive and complex clinical and imaging parameters. Methods: Hundred and forty-six MS patients underwent HLA typing. Over a 4-year period of follow-up, we performed three clinical and magnetic resonance imaging (MRI) assessments per patient, which respectively included Expanded Disability Status Scale, Multiple Sclerosis Severity Scale, Timed-25-Foot-Walk, 9-Hole Peg Test, Symbol Digit Modalities Test, Brief Visual Memory Test, California Verbal Learning Test-II, and whole-brain atrophy, fluid-attenuated inversion recovery (FLAIR) lesion volume change and number of new FLAIR lesions using icobrain. We then compared the clinical and MRI outcomes between predefined HLA patient groups. Results: Results of this larger study with a longer follow-up are in line with what we have previously shown. HLA-A∗02 allele is associated with potentially better MS outcomes, whereas HLA-B∗07, HLA-B∗44, HLA-B∗08, and HLA-DQB1∗06 with a potential negative effect. Results for HLA-DRB1∗15 are inconclusive. Conclusion: In the era of MS treatment abundance, HLA genotype might serve as an early biomarker for MS outcomes to inform individualized treatment decisions., SCOPUS: ar.j, DecretOANoAutActif, info:eu-repo/semantics/published

Published
2020

25. Diffusion tensor imaging of the anterior cruciate ligament graft following reconstruction: a longitudinal study

Author

Highfield Research Group, Regenerative Medicine and Stem Cells, Cancer, Brain, Circulatory Health, Van Dyck, Pieter, Billiet, Thibo, Desbuquoit, Damien, Verdonk, Peter, Heusdens, Christiaan H, Roelant, Ella, Sijbers, Jan, Froeling, Martijn, Highfield Research Group, Regenerative Medicine and Stem Cells, Cancer, Brain, Circulatory Health, Van Dyck, Pieter, Billiet, Thibo, Desbuquoit, Damien, Verdonk, Peter, Heusdens, Christiaan H, Roelant, Ella, Sijbers, Jan, and Froeling, Martijn

Published
2020

28. Long-term effectiveness of natalizumab on MRI outcomes and no evidence of disease activity in relapsing-remitting multiple sclerosis patients treated in a Czech Republic real-world setting: A longitudinal, retrospective study

Author

Horakova, Dana, primary, Uher, Tomas, additional, Krasensky, Jan, additional, Seidl, Zdeněk, additional, Ribbens, Annemie, additional, Van Hecke, Wim, additional, Billiet, Thibo, additional, Koendgen, Harold, additional, Freudensprung, Ulrich, additional, Hyde, Robert, additional, and Vaneckova, Manuela, additional

Published
2020
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29. Harmonization of Brain Diffusion MRI: Concepts and Methods

Author

Pinto, Maíra Siqueira, primary, Paolella, Roberto, additional, Billiet, Thibo, additional, Van Dyck, Pieter, additional, Guns, Pieter-Jan, additional, Jeurissen, Ben, additional, Ribbens, Annemie, additional, den Dekker, Arnold J., additional, and Sijbers, Jan, additional

Published
2020
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32. Short-term MRI-based Prediction of Clinical MS Progression in a Real World Setting

Author

Van Hecke, Wim, Sima, Diana, Billiet, Thibo, Van Schependom, Jeroen, Ernon, Christine, D'Hooghe, Marie, Dive, Dominique, Nagels, Guy, Smeets, Dirk, Electronics and Informatics, Clinical sciences, Neuroprotection & Neuromodulation, and Neurology

Subjects
Neuroscience(all), Clinical MS Progression, Short-term MRI-based Prediction
Published
2019

33. Human Leukocyte Antigen Genotype as a Marker of Multiple Sclerosis Prognosis

Author

UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, Lysandropoulos, Andreas P., Perrotta, Gaetano, Billiet, Thibo, Ribbens, Annemie, Du Pasquier, Renaud, Pot Kreis, Caroline, Maggi, Pietro, Théaudin, Marie, UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, Lysandropoulos, Andreas P., Perrotta, Gaetano, Billiet, Thibo, Ribbens, Annemie, Du Pasquier, Renaud, Pot Kreis, Caroline, Maggi, Pietro, and Théaudin, Marie

Abstract

In a previous pilot monocentric study, we investigated the relation between human leukocyte antigen (HLA) genotype and multiple sclerosis (MS) disease progression over 2 years. HLA-A*02 allele was correlated with better outcomes, whereas HLA-B*07 and HLA-B*44 were correlated with worse outcomes. The objective of this extension study was to further investigate the possible association of HLA genotype with disease status and progression in MS as measured by sensitive and complex clinical and imaging parameters.

Published
2019

34. Diffusion tensor imaging of the anterior cruciate ligament following primary repair with internal bracing: A longitudinal study.

Author

Van Dyck, Pieter, Froeling, Martijn, Heusdens, Christiaan H. W., Sijbers, Jan, Ribbens, Annemie, and Billiet, Thibo

Subjects
ANTERIOR cruciate ligament, DIFFUSION tensor imaging, POSTERIOR cruciate ligament, DIFFUSION magnetic resonance imaging, LONGITUDINAL method
Abstract

Diffusion tensor imaging (DTI) provides information about tissue microstructure and its degree of organization by quantifying water diffusion. We aimed to monitor longitudinal changes in DTI parameters (fractional isotropy, FA; mean diffusivity, MD; axial diffusivity, AD; radial diffusivity, RD) of the anterior cruciate ligament (ACL) following primary repair with internal bracing (IBLA). Fourteen patients undergoing IBLA were enrolled prospectively and scheduled for clinical follow‐up, including instrumented laxity testing, and DTI at 3, 6, 12, and 24 months postoperatively. DTI was also performed in seven healthy subjects. Fiber tractography was used for 3D segmentation of the whole ACL volume, from which median DTI parameters were calculated. The posterior cruciate ligament (PCL) served as a control. Longitudinal DTI changes were assessed using a linear mixed model, and repeated measures correlations were calculated between DTI parameters and clinical laxity tests. At follow‐up, thirteen patients had a stable knee and one patient sustained an ACL rerupture after 12 months postoperatively. The ACL repair showed a significant decrease of FA within the first 12 months after surgery, followed by stable FA values thereafter, while ACL diffusivities decreased over time returning towards normal values at 24 months postoperatively. For PCL there were no significant DTI changes over time. There was a significant correlation between ACL FA and laxity tests (r = −0.42, P =.017). This study has shown the potential of DTI to longitudinally monitor diffusion changes in the ACL following IBLA. The DTI findings suggest that healing of the ACL repair is incomplete at 24 months postoperatively. [ABSTRACT FROM AUTHOR]

Published
2021
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35. Tolerogenic dendritic cell-based treatment for multiple sclerosis (MS): a harmonised study protocol for two phase I clinical trials comparing intradermal and intranodal cell administration

Author

Willekens, Barbara, primary, Presas-Rodríguez, Silvia, additional, Mansilla, MJ, additional, Derdelinckx, Judith, additional, Lee, Wai-Ping, additional, Nijs, Griet, additional, De Laere, Maxime, additional, Wens, Inez, additional, Cras, Patrick, additional, Parizel, Paul, additional, Van Hecke, Wim, additional, Ribbens, Annemie, additional, Billiet, Thibo, additional, Adams, Geert, additional, Couttenye, Marie-Madeleine, additional, Navarro-Barriuso, Juan, additional, Teniente-Serra, Aina, additional, Quirant-Sánchez, Bibiana, additional, Lopez-Diaz de Cerio, Ascensión, additional, Inogés, Susana, additional, Prosper, Felipe, additional, Kip, Anke, additional, Verheij, Herman, additional, Gross, Catharina C, additional, Wiendl, Heinz, additional, Van Ham, Marieke (SM), additional, Ten Brinke, Anja, additional, Barriocanal, Ana Maria, additional, Massuet-Vilamajó, Anna, additional, Hens, Niel, additional, Berneman, Zwi, additional, Martínez-Cáceres, Eva, additional, Cools, Nathalie, additional, and Ramo-Tello, Cristina, additional

Published
2019
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36. New/Enlarging Lesion Count: Man versus Machine (P5.2-027)

Author

Van Hecke, Wim, primary, Ribbens, Annemie, additional, Billiet, Thibo, additional, Zivadinov, Robert, additional, Ramasamy, Deepa P., additional, Dwyer, Michael G., additional, Bergsland, Niels, additional, Carl, Ellen, additional, Wang, Chenyu, additional, Ly, Linda, additional, Barnett, Yael, additional, Masters, Lynette, additional, Barnett, Michael H., additional, and Beadnall, Heidi N., additional

Published
2019
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39. Recovery from chemotherapy-induced white matter changes in young breast cancer survivors?

Author

Beeldverwerking ISI, Brain, Pathologie Pathologen staf, Cancer, Billiet, Thibo, Emsell, Louise, Vandenbulcke, Mathieu, Peeters, Ronald, Christiaens, Daan, Leemans, Alexander, van Hecke, Wim, Smeets, Ann, Amant, Frederic, Sunaert, Stefan, Deprez, Sabine, Beeldverwerking ISI, Brain, Pathologie Pathologen staf, Cancer, Billiet, Thibo, Emsell, Louise, Vandenbulcke, Mathieu, Peeters, Ronald, Christiaens, Daan, Leemans, Alexander, van Hecke, Wim, Smeets, Ann, Amant, Frederic, Sunaert, Stefan, and Deprez, Sabine

Published
2018

45. HLA genotype as a marker of multiple sclerosis prognosis: A pilot study

Author

Lysandropoulos, Andreas, Mavroudakis, Nicolas, Pandolfo, Massimo, El Hafsi, Kaoutar, Van Hecke, Wim, Maertens, Anke, Billiet, Thibo, Ribbens, Annemie, Lysandropoulos, Andreas, Mavroudakis, Nicolas, Pandolfo, Massimo, El Hafsi, Kaoutar, Van Hecke, Wim, Maertens, Anke, Billiet, Thibo, and Ribbens, Annemie

Abstract

Objective The identification of a biomarker with prognostic value is an unmet need in multiple sclerosis (MS). The objective of this study was to investigate a possible association of HLA genotype with disease status and progression in MS, based on comprehensive and sensitive clinical and magnetic resonance imaging (MRI) parameters to measure disease effects. Method A total of 118 MS patients (79 females, 39 males) underwent HLA typing. Patient MS status was assessed at two time points in a 2-year interval, based on clinical scores (including EDSS, MSSS, T25FW, 9-HPT, SDMT, BVMT, CVLT-II) and MRI evaluations. Quantitative brain MRI values were obtained for whole brain atrophy, FLAIR lesion volume change and number of new lesions using MSmetrix. Predefined HLA patient groups were compared as of disease status and progression. Global assessment was achieved by an overall t-statistic and assessment per measurement by a Welch test and/or Mann Whitney U test. The effects of multiple covariates, including age, gender and disease duration as well as scan parameters, were also evaluated using a regression analysis. Results The HLA-A*02 allele was associated with better outcomes in terms of MSSS, EDSS and new lesion count (Welch test p-value < 0.05). The HLA-B*07 and HLA-B*44 alleles showed a global negative effect on disease status, although none of the measurements reached significance (p-value < 0.05). Results for the HLA-DRB1*15, HLA-DQB1*06 and HLA-B*08 alleles were inconclusive. The influence of the confounding variables on the statistical analysis was limited., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2017

47. THE “A/T/N” SYSTEM: ADDED PREDICTIVE VALUE OF N BIOMARKERS OF PROGRESSION FROM MCI TO DEMENTIA OVER 2 AND 4 YEARS

Author

Struyfs, Hanne, primary, Pascoal, Tharick A., additional, Ng, Kok Pin, additional, Mathotaarachchi, Sulantha S., additional, Benedet, Andrea Lessa, additional, Kang, Min Su, additional, Shin, Monica, additional, Therriault, Joseph, additional, Billiet, Thibo, additional, Smeets, Dirk, additional, Ribbens, Annemie, additional, Gauthier, Serge, additional, Bjerke, Maria, additional, Engelborghs, Sebastiaan, additional, and Rosa-Neto, Pedro, additional

Published
2017
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49. Association of Quantitative MRI to Radiological Reporting for the Evaluation of Lesion Burden Status in Multiple Sclerosis: A Multi-Center Study (P4.358)

Author

Ribbens, Annemie, primary, Billiet, Thibo, additional, Beadnall, Heidi, additional, Vaneckova, Manuela, additional, Weinstock-Guttman, Bianca, additional, Ly, Linda, additional, Wang, Chenyu, additional, Ramasamy, Deepa, additional, Houbrechts, Ruben, additional, Bergsland, Niels, additional, Seidl, Zdenek, additional, Uher, Tomas, additional, Van Hecke, Wim, additional, Horakova, Dana, additional, Zivadinov, Robert, additional, and Barnett, Michael, additional

Published
2017
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50. Assessment of Brain Atrophy in Multiple Sclerosis Patients in Clinical Routine: A Multi-Center Comparison Study of Radiological and Quantitative Reports (P4.373)

Author

Ribbens, Annemie, primary, Billiet, Thibo, additional, Beadnall, Heidi, additional, Vaneckova, Manuela, additional, Weinstock-Guttman, Bianca, additional, Ly, Linda, additional, Wang, Chenyu, additional, Carl, Ellen, additional, Claes, Lene, additional, Dwyer, Michael, additional, Krasensky, Jan, additional, Uher, Tomas, additional, Horakova, Dana, additional, Van Hecke, Wim, additional, Barnett, Michael, additional, and Zivadinov, Robert, additional

Published
2017
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