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1. Predicting programmed death-ligand 1 (PD-L1) expression with fluorine-18 fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) metabolic parameters in resectable non-small cell lung cancer

Author

Hughes, Daniel Johnathan, Josephides, Eleni, O’Shea, Robert, Manickavasagar, Thubeena, Horst, Carolyn, Hunter, Sarah, Tanière, Philippe, Nonaka, Daisuke, Van Hemelrijck, Mieke, Spicer, James, Goh, Vicky, Bille, Andrea, Karapanagiotou, Eleni, and Cook, Gary J. R.

Published
2024
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4. The International Association for the Study of Lung Cancer Pleural Mesothelioma Staging Project: Proposal for Revision of the TNM Stage Groupings in the Forthcoming (Ninth) Edition of the TNM Classification for Pleural Mesothelioma

Author

Nowak, Anna K., Giroux, Dorothy J., Eisele, Megan, Rosenthal, Adam, Bille, Andrea, Gill, Ritu R., Kindler, Hedy L., Pass, Harvey I., Rice, David, Ripley, R Taylor, Wolf, Andrea, Friedberg, Joseph, Nishimura, Katherine, and Rusch, Valerie W.

Published
2024
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5. The International Association for the Study of Lung Cancer Pleural Mesothelioma Staging Project: Expanded Database to Inform Revisions in the Ninth Edition of the TNM Classification of Pleural Mesothelioma

Author

Wolf, Andrea S., Eisele, Megan, Giroux, Dorothy J., Gill, Ritu, Nowak, Anna K., Bille, Andrea, Rice, David, Ripley, Robert T., Opitz, Isabelle, Galateau-Salle, Francoise, Hasegawa, Seiki, Kindler, Hedy L., Pass, Harvey I., and Rusch, Valerie W.

Published
2024
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6. Extended pleurectomy decortication and chemotherapy versus chemotherapy alone for pleural mesothelioma (MARS 2): a phase 3 randomised controlled trial

Author

Lim, Eric, Waller, David, Lau, Kelvin, Steele, Jeremy, Pope, Anthony, Ali, Clinton, Bilancia, Rocco, Keni, Manjusha, Popat, Sanjay, O'Brien, Mary, Tokaca, Nadza, Maskell, Nick, Stadon, Louise, Fennell, Dean, Nelson, Louise, Edwards, John, Tenconi, Sara, Socci, Laura, Rintoul, Robert C, Wood, Kelly, Stone, Amanda, Muthukumar, Dakshinamoorthy, Ingle, Charlotte, Taylor, Paul, Cove-Smith, Laura, Califano, Raffaele, Summers, Yvonne, Tasigiannopoulos, Zacharias, Bille, Andrea, Shah, Riyaz, Fuller, Elizabeth, Macnair, Andrew, Shamash, Jonathan, Mansy, Talal, Milton, Richard, Koh, Pek, Ionescu, Andreea Alina, Treece, Sarah, Roy, Amy, Middleton, Gary, Kirk, Alan, Harris, Rosie A, Ashton, Kate, Warnes, Barbara, Bridgeman, Emma, Joyce, Katherine, Mills, Nicola, Elliott, Daisy, Farrar, Nicola, Stokes, Elizabeth, Hughes, Vikki, Nicholson, Andrew G, and Rogers, Chris A

Published
2024
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7. The International Association for the Study of Lung Cancer Staging Project for Lung Cancer: Proposals for the Revision of the N Descriptors in the Forthcoming Ninth Edition of the TNM Classification for Lung Cancer

Author

Huang, James, Osarogiagbon, Raymond U., Giroux, Dorothy J., Nishimura, Katherine K., Bille, Andrea, Cardillo, Giuseppe, Detterbeck, Frank, Kernstine, Kemp, Kim, Hong Kwan, Lievens, Yolande, Lim, Eric, Marom, Edith, Prosch, Helmut, Putora, Paul Martin, Rami-Porta, Ramon, Rice, David, Rocco, Gaetano, Rusch, Valerie W., Opitz, Isabelle, Vasquez, Francisco Suarez, Van Schil, Paul, Jeffrey Yang, Chi-Fu, and Asamura, Hisao

Published
2024
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8. The International Association for the Study of Lung Cancer Thymic Epithelial Tumors Staging Project: Proposals for the N and the M Components for the Forthcoming (Ninth) Edition of the TNM Classification of Malignant Tumors

Author

Fang, Wentao, Girard, Nicolas, Cilento, Vanessa, Goren, Emily, Dibaba, Daniel, Ruffini, Enrico, Ahmad, Usman, Appel, Sarit, Bille, Andrea, Boubia, Souheil, Brambilla, Cecilia, Cangir, Ayten Kayi, Detterbeck, Frank, Falkson, Conrad, Filosso, Pier Luigi, Giaccone, Giuseppe, Guerrera, Francesco, Huang, James, Infante, Maurizio, Kim, Dong Kwan, Lucchi, Marco, Marino, Mirella, Marom, Edith M., Nicholson, Andrew G., Okumura, Meinoshin, Rami-Porta, Ramon, Rimner, Andreas, Simone, Charles B., II, and Asamura, Hisao

Published
2024
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9. The International Association for the Study of Lung Cancer Thymic Epithelial Tumor Staging Project: A Re-Assessment of the International Thymic Malignancy Interest Group/International Association for the Study of Lung Cancer Lymph Node Map for Thymic Epithelial Tumors for the Forthcoming Ninth Edition of the TNM Classification of Malignant Tumors

Author

Marom, Edith M., Fang, Wentao, Ruffini, Enrico, Detterbeck, Frank, Ahmad, Usman, Appel, Sarit, Bille, Andrea, Boubia, Souheil, Brambilla, Cecilia, Cilento, Vanessa, Cangir, Ayten Kayi, Falkson, Conrad, Filosso, Pier Luigi, Giaccone, Giuseppe, Girard, Nicolas, Goren, Emily, Guerrera, Francesco, Huang, James, Infante, Maurizio, Kim, Dong-Kwan, Lucchi, Marco, Marino, Mirella, Nicholson, Andrew G., Okumura, Meinoshin, Rami-Porta, Ramon, Rimner, Andreas, Simone, Charles B., II, and Asamura, Hisao

Published
2023
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10. The International Association for the Study of Lung Cancer Thymic Epithelial Tumors Staging Project: Proposal for a Stage Classification for the Forthcoming (Ninth) Edition of the TNM Classification of Malignant Tumors

Author

Ruffini, Enrico, Huang, James, Cilento, Vanessa, Goren, Emily, Detterbeck, Frank, Ahmad, Usman, Appel, Sarit, Bille, Andrea, Boubia, Souheil, Brambilla, Cecilia, Cangir, Ayten Kayi, Falkson, Conrad, Fang, Wentao, Filosso, Pier Luigi, Giaccone, Giuseppe, Girard, Nicolas, Guerrera, Francesco, Infante, Maurizio, Kim, Dong Kwan, Lucchi, Marco, Marino, Mirella, Marom, Edith M., Nicholson, Andrew G., Okumura, Meinoshin, Rami-Porta, Ramon, Rimner, Andreas, Simone, Charles B., II, and Asamura, Hisao

Published
2023
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11. The International Association for the Study of Lung Cancer Thymic Epithelial Tumor Staging Project: Proposal for the T Component for the Forthcoming (Ninth) Edition of the TNM Classification of Malignant Tumors

Author

Okumura, Meinoshin, Marino, Mirella, Cilento, Vanessa, Goren, Emily, Ruffini, Enrico, Dibaba, Daniel, Ahmad, Usman, Appel, Sarit, Bille, Andrea, Boubia, Souheil, Brambilla, Cecilia, Cangir, Ayten Kayi, Detterbeck, Frank, Falkson, Conrad, Fang, Wentao, Filosso, Pier Luigi, Giaccone, Giuseppe, Girard, Nicolas, Guerrera, Francesco, Huang, James, Infante, Maurizio, Kim, Dong Kwan, Lucchi, Marco, Marom, Edith M., Nicholson, Andrew G., Rami-Porta, Ramon, Rimner, Andreas, Simone, Charles B., II, and Asamura, Hisao

Published
2023
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13. The International Association for the Study of Lung Cancer Thymic Epithelial Tumors Staging Project: An Overview of the Central Database Informing Revision of the Forthcoming (Ninth) Edition of the TNM Classification of Malignant Tumors

Author

Rimner, Andreas, Ruffini, Enrico, Cilento, Vanessa, Goren, Emily, Ahmad, Usman, Appel, Sarit, Bille, Andrea, Boubia, Souheil, Brambilla, Cecilia, Cangir, Ayten Kayi, Detterbeck, Frank, Falkson, Conrad, Fang, Wentao, Filosso, Pier Luigi, Giaccone, Giuseppe, Girard, Nicolas, Guerrera, Francesco, Huang, James, Infante, Maurizio, Kim, Dong Kwan, Lucchi, Marco, Marino, Mirella, Marom, Edith M., Nicholson, Andrew G., Okumura, Meinoshin, Rami-Porta, Ramon, Simone, Charles B., II, and Asamura, Hisao

Published
2023
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14. European Epidemiology of Pleural Mesothelioma—Real-Life Data From a Joint Analysis of the Mesoscape Database of the European Thoracic Oncology Platform and the European Society of Thoracic Surgery Mesothelioma Database

Author

Stahel, Rolf, Hiltbrunner, Anita, Kammler, Rosita, Marti, Nesa, Ruepp, Barbara, Dafni, Urania, Tsourti, Zoi, Zygoura, Panagiota, Vervita, Katerina, Dimopoulou, Georgia, Andriakopoulou, Charitini, Stavrou, Androniki, Rüschoff, Jan H., Haberecker, Martina, Dettwiler, Susanne, Prutek, Fabiola, Mittmann, Christiane, Opitz, Isabelle, Vrugt, Bart, Friess, Martina, Matter, Alessandra, Spichiger-Häusermann, Chloé, Kirschner, Michaela B., Felley-Bosco, Emanuela, Baas, Paul, Monkhorst, Kim, Nackaerts, Kristiaan, Verbeken, Eric, Weynand, Birgit, Nafteux, Philippe, Moons, Johnny, Peeters, Liesbet, Ampollini, Luca, Tiseo, Marcello, Silini, Enrico Maria, Gnetti, Letizia, Carbognani, Paolo, de Perrot, Marc, Bavaghar-Zaeimi, Fatemeh, Brcic, Luka, Samarzija, Miroslav, Seiwerth, Sven, Jakopovic, Marko, Nadal, Ernest, Cardenal, Felipe, Llatjos, Roger, Lorente, Susana, Syrigos, Konstantinos, Vamvakaris, Ioannis, Tsimpoukis, Sotirios, Boura, Paraskevi, Gray, Steven G., Finn, Stephen P., Nur, Mutaz Mohammed, Baird, Anne-Marie, Barr, Martin P., Cuffe, Sinead, Gately, Kathy, Aerts, Joachim, Thüsen, Jan von der, Bille, Andrea, Passani, Stefano, Brunelli, Alessandro, Curioni-Fontecedro, Alessandra, von der Thüsen, Jan, Kammler, Roswitha, Peters, Solange, Stahel, Rolf A., and Falcoz, Pierre-Emmanuel

Published
2023
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16. IASLC Lung Cancer Staging Project: The New Database to Inform Revisions in the Ninth Edition of the TNM Classification of Lung Cancer

Author

Asamura, Hisao, Rusch, Valerie, Rami-Porta, Ramón, Araujo, Luiz Henrique, Beer, David, Bertoglio, Pietro, Beyruti, Ricardo, Billè, Andrea, Boubia, Souheil, Brambilla, Elisabeth, Cangir, A.K., Carbone, David, Cilento, Vanessa, Connolly, Casey, Darling, Gail, Detterbeck, Frank, Dibaba, Daniel, D’Journo, Xavier Benoit, Donington, Jessica, Eberhardt, Wilfried, Edwards, John, Erasmus, Jeremy, Fang, Wentao, Fennell, Dean, Fong, Kwun, Galateau-Sallé, Françoise, Gautschi, Oliver, Gill, Ritu R., Giroux, Dorothy, Giuliani, Meredith, Goo, Jin Mo, Hasegawa, Seiki, Hirsch, Fred, Hoffman, Hans, Hofstetter, Wayne, Huang, James, Joubert, Philippe, Kernstine, Kemp, Kerr, Keith, Kim, Young Tae, Kim, Dong Kwan, Kindler, Hedy, Lievens, Yolande, Liu, Hui, Low, Donald E., Lyons, Gustavo, MacMahon, Heber, Mahar, Alyson, Marino, Mirella, Marom, Edith M., Matilla, José-María, van Meerbeeck, Jan, Montuenga, Luis M., Nicholson, Andrew, Nishimura, Katie, Nowak, Anna, Opitz, Isabelle, Okumura, Meinoshin, Osarogiagbon, Raymond U., Pass, Harvey, de Perrot, Marc, Prosch, Helmut, Rice, David, Rimner, Andreas, Rosenthal, Adam, Ruffini, Enrico, Sakai, Shuji, Van Schil, Paul, Singh, Navneet, Suárez, Francisco, Terra, Ricardo M., Travis, William D., Tsao, Ming S., Ugalde, Paula, Watanabe, Shun-ichi, Wistuba, Ignacio, Wynes, Murry, Yatabe, Yasushi, Nishimura, Katherine K., Giroux, Dorothy J., Chansky, Kari, and Hoering, Antje

Published
2023
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18. 126 Exploring Real-World Treatment Patterns and Outcomes in Stage IIIA N2 Non-Small Cell Lung Cancer (NSCLC)

Author

Josephides, Eleni, primary, Dunn, Roberta, additional, Faranghi, Mona, additional, Henry, Annie-Rose, additional, Pilling, John, additional, Harrison-Phipps, Karen, additional, Ahmad, Shahreen, additional, Skwarski, Michael, additional, Taylor, Benjamin, additional, Spicer, James, additional, Georgiou, Alexandros, additional, Ghosh, Sharmistha, additional, Santis, George, additional, Breen, Ronan, additional, Van Hemelrijck, Mieke, additional, Karapanagiotou, Eleni, additional, Smith, Daniel, additional, and Bille, Andrea, additional

Published
2024
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21. Predicting programmed death-ligand 1 (PD-L1) expression with fluorine-18 fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) metabolic parameters in resectable non-small cell lung cancer.

Author

Hughes, Daniel Johnathan, Josephides, Eleni, O'Shea, Robert, Manickavasagar, Thubeena, Horst, Carolyn, Hunter, Sarah, Tanière, Philippe, Nonaka, Daisuke, Van Hemelrijck, Mieke, Spicer, James, Goh, Vicky, Bille, Andrea, Karapanagiotou, Eleni, and Cook, Gary J. R.

Subjects
PROGRAMMED death-ligand 1, POSITRON emission tomography, NON-small-cell lung carcinoma, LEAN body mass, COMPUTED tomography
Abstract

Background: Programmed death-ligand 1 (PD-L1) expression is a predictive biomarker for immunotherapy in non-small cell lung cancer (NSCLC). PD-L1 and glucose transporter 1 expression are closely associated, and studies demonstrate correlation of PD-L1 with glucose metabolism. Aim: The aim of this study was to investigate the association of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG-PET/CT) metabolic parameters with PD-L1 expression in primary lung tumour and lymph node metastases in resected NSCLC. Methods: We conducted a retrospective analysis of 210 patients with node-positive resectable stage IIB–IIIB NSCLC. PD-L1 tumour proportion score (TPS) was determined using the DAKO 22C3 immunohistochemical assay. Semi-automated techniques were used to analyse pre-operative [18F]FDG-PET/CT images to determine primary and nodal metabolic parameter scores (including max, mean, peak and peak adjusted for lean body mass standardised uptake values (SUV), metabolic tumour volume (MTV), total lesional glycolysis (TLG) and SUV heterogeneity index (HISUV)). Results: Patients were predominantly male (57%), median age 70 years with non-squamous NSCLC (68%). A majority had negative primary tumour PD-L1 (TPS < 1%; 53%). Mean SUVmax, SUVmean, SUVpeak and SULpeak values were significantly higher (p < 0.05) in those with TPS ≥ 1% in primary tumour (n = 210) or lymph nodes (n = 91). However, ROC analysis demonstrated only moderate separability at the 1% PD-L1 TPS threshold (AUCs 0.58–0.73). There was no association of MTV, TLG and HISUV with PD-L1 TPS. Conclusion: This study demonstrated the association of SUV-based [18F]FDG-PET/CT metabolic parameters with PD-L1 expression in primary tumour or lymph node metastasis in resectable NSCLC, but with poor sensitivity and specificity for predicting PD-L1 positivity ≥ 1%. Clinical relevance statement: Whilst SUV-based fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography metabolic parameters may not predict programmed death-ligand 1 positivity ≥ 1% in the primary tumour and lymph nodes of resectable non-small cell lung cancer independently, there is a clear association which warrants further investigation in prospective studies. Trial registration: Non-applicable Key Points: • Programmed death-ligand 1 immunohistochemistry has a predictive role in non-small cell lung cancer immunotherapy; however, it is both heterogenous and dynamic. • SUV-based fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG-PET/CT) metabolic parameters were significantly higher in primary tumour or lymph node metastases with positive programmed death-ligand 1 expression. • These SUV-based parameters could potentially play an additive role along with other multi-modal biomarkers in selecting patients within a predictive nomogram. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Squamous Cell Carcinoma in Never Smokers: An Insight into SMARCB1 Loss.

Author

Patel, Akshay J., Hemead, Hanan, Jesani, Hannah, Bille, Andrea, Taniere, Philippe, and Middleton, Gary

Subjects
NON-small-cell lung carcinoma, SQUAMOUS cell carcinoma, LUNG cancer, OVERALL survival, PROGRESSION-free survival
Abstract

Lung cancer remains the leading cause of cancer-related mortality worldwide, with non-small cell lung cancer (NSCLC) constituting 85% of cases. Among NSCLCs, squamous cell carcinoma (SqCC) is strongly associated with smoking. However, lung cancer in never smokers (LCINS) represents approximately 25% of lung cancer cases globally and shows increasing incidence, particularly in East Asia. LCINS-SqCC is less well-characterized, especially regarding its genomic alterations and their impact on clinical outcomes. We conducted a retrospective analysis over a 20-year period (July 2003–July 2023) at two major tertiary centers in the UK. The cohort included 59 patients with LCINS-SqCC who underwent radical surgical resection. Data collected included demographic information, comorbidities, histopathological details, and outcome metrics such as disease-free and overall survival. Molecular sequencing of tumor specimens was performed to identify genomic aberrations. The cohort had a median age of 71 years (IQR 62–77) and a median BMI of 25.4 (IQR 22.8–27.8), with a slight male predominance (53%). The majority of patients (93%) had a preoperative MRC of 1–2. Recurrent disease was observed in 23 patients (39%), and 32 patients (54%) had died at a median follow-up of 3 years. Median disease-free survival was 545 days (IQR 132–1496), and overall survival was 888 days (IQR 443–2071). Preoperative creatinine levels were higher in patients who experienced recurrence (p = 0.037). Molecular analysis identified biallelic SMARCB1 loss in two younger patients, associated with rapid disease progression despite R0 resection. These patients' tumors were PDL1-negative, TTF-1-negative, and positive for cytokeratin, CD56, and p40. SMARCB1-deficient SqCC in never smokers represents a highly aggressive variant with poor disease-free survival, highlighting the importance of integrating advanced molecular diagnostics in clinical practice. This study underscores the necessity for personalized treatment strategies, including targeted therapies such as EZH2 inhibitors and immune checkpoint blockade, to address the unique molecular pathways in SMARCB1-deficient cancers. Further clinical trials are essential to optimize therapeutic approaches for this challenging subgroup of lung cancer. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Maintaining safe lung cancer surgery during the COVID-19 pandemic in a global city

Author

Fraser, Stephanie, Baranowski, Ralitsa, Patrini, Davide, Nandi, Jay, Al-Sahaf, May, Smelt, Jeremy, Hoffman, Ross, Santhirakumaran, Gowthanan, Lee, Michelle, Wali, Anuj, Dickinson, Harvey, Jadoon, Mehmood, Harrison-Phipps, Karen, King, Juliet, Pilling, John, Bille, Andrea, Okiror, Lawrence, Stamenkovic, Sasha, Waller, David, Wilson, Henrietta, Jordan, Simon, Begum, Sofina, Buderi, Silviu, Tan, Carol, Hunt, Ian, Vaughan, Paul, Jenkins, Melanie, Hayward, Martin, Lawrence, David, Beddow, Emma, Anikin, Vladimir, Mani, Aleksander, Finch, Jonathan, Maheswaran, Hendramoorthy, Lim, Eric, Routledge, Tom, Lau, Kelvin, and Harling, Leanne

Published
2021
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31. The IASLC Lung Cancer Staging Project: Analysis of Resection Margin Status and Proposals for Residual Tumor Descriptors for Non–Small Cell Lung Cancer

Author

Asamura, Hisao, Rusch, Valerie, Rami-Porta, Ramón, Araujo, Luiz Henrique, Beer, David, Bertoglio, Pietro, Beyruti, Ricardo, Bille, Andrea, Bolejack, Vanessa, Boubia, Souheil, Brambilla, Elisabeth, Brierley, James D., Cangir, A.K., Carbone, David, Chansky, Kari, Crowley, John, Darling, Gail, Detterbeck, Frank, D’Journo, Xavier Benoit, Donnington, Jessica, Eberhardt, Wilfried, Edwards, John, Erasmus, Jeremy, Falkson, Conrad, Fang, Wentao, Fennell, Dean, Fong, Kwun, Galateau-Salle, Françoise, Gautschi, Oliver, Gill, Ritu, Giroux, Dorothy, Giuliani, Meredith, Goo, Jin Mo, Hasegawa, Seiki, Hirsch, Fred, Hoffman, Hans, Hofstetter, Wayne, Huang, James, Joubert, Philippe, Kernstine, Kemp, Kerr, Keith, Kim, Young Tae, Kim, Hong Kwan, Kindler, Hedy, Lievens, Yolande, Liu, Hui, Low, Donald E., Lyons, Gustavo, MacMahon, Heber, Marino, Mirella, Marom, Edith, Matilla, José-María, van Meerbeeck, Jan, Montuenga, Luis M., Nicholson, Andrew, Nishimura, Katie, Nowak, Anna, Opitz, Isabelle, Okumura, Meinoshin, Osarogiagbon, Raymond U., Pass, Harvey, de Perrot, Marc, Prosch, Helmut, Rice, David, Rimner, Andreas, Ruffini, Enrico, Sakai, Shuji, Van Schil, Paul, Singh, Navneet, Stoll-D’Astice, Amy, Su´rez, Francisco, Terra, Ricardo M., Travis, William D., Tsao, Ming S., Ugalde, Paula, Waller, David, Watanabe, Shun-ichi, Wiens, Jacinta, Wistuba, Ignacio, Yatabe, Yasushi, Jiang, Liyan, Kubota, Kaoru, Turna, Akif, Weksler, Benny, Tzukazan, Maria Teresa, Tammemägi, Martin, Powell, Charles, Naidich, David, Liu, Hongxu, Armato, Samuel, Brunelli, Alex, Cardillo, Giuseppe, David, Elizabeth, Fournier, Brigitte, Krasnik, Mark, Kubota, Kauro, Labbe, Catherine, Lim, Eric, Putora, Paul Martin, Rocco, Gaetano, Filosso, Pier Luigi, Kondo, Kazuya, Kim, Dong Kwan, Giaccone, Giuseppe, Lucchi, Marco, Infante, Maurizio, Rice, Thomas, Ferguson, Mark, Adsusmilli, Prasad, Travis, William, Suárez, Francisco, Kubota, Kaura, Shun-ichi, Watanabe, Hisao Asamura, Nicholson, Andrew G., Ramón, Rami-Porta, Edith Marom, Tsao, Ming, Shun-ichi, Watanabe, Ming Tsao, Guiliani, Meredith, Brierley, James, Terra, Ricardo, Osarogiagbon, Ray, Montuenga, Luis, Wang, Hongwei, Nakajima, Jun, Galateau, Françoise, Ostrowski, Marcin, Goo, Jim Mo, Travis, Bill, Matilla, Jose Maria, St. Pierre, Carolle, Tzukazan, Ma Teresa, Girard, Nicholas, Rimmer, Andreas, Galateau, Francoise, Adusumilli, Prasad, D’Journo, Xavier, Low, Donald, Rosenthal, Adam, Edwards, John G., Donington, Jessica, Galateau-Sallé, Françoise, Hoffmann, Hans, Marom, Edith M., Tsao, Ming-Sound, Giroux, Dorothy J., Shemanski, Lynn, and Krasnik, Marc

Published
2020
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32. The International Association for the Study of Lung Cancer Thymic Tumors Staging Project: The Impact of the Eighth Edition of the Union for International Cancer Control and American Joint Committee on Cancer TNM Stage Classification of Thymic Tumors

Author

Ruffini, Enrico, Fang, Wentao, Guerrera, Francesco, Huang, James, Okumura, Meinoshin, Kim, Dong Kwan, Girard, Nicolas, Billè, Andrea, Boubia, Souheil, Cangir, Ayten Kayi, Detterbeck, Frank, Falkson, Conrad, Filosso, Pier Luigi, Giaccone, Giuseppe, Kondo, Kazuya, Infante, Maurizio, Lucchi, Marco, Marino, Mirella, Marom, Edith M., Nicholson, Andrew G., Rimner, Andreas, Rami-Porta, Ramon, and Asamura, Hisao

Published
2020
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36. The IASLC Lung Cancer Staging Project: Proposals for the Revision of the N Descriptors in the Forthcoming 9th Edition of the TNM Classification for Lung Cancer

Author

Huang, James, primary, Osarogiagbon, Raymond U., additional, Giroux, Dorothy J., additional, Nishimura, Katherine K., additional, Bille, Andrea, additional, Cardillo, Giuseppe, additional, Detterbeck, Frank, additional, Kernstine, Kemp, additional, Kim, Hong Kwan, additional, Lievens, Yolande, additional, Lim, Eric, additional, Marom, Edith, additional, Prosch, Helmut, additional, Putora, Paul Martin, additional, Rami-Porta, Ramon, additional, Rice, David, additional, Rocco, Gaetano, additional, Rusch, Valerie W., additional, Opitz, Isabelle, additional, Vasquez, Francisco Suarez, additional, Van Schil, Paul, additional, Jeffrey Yang, Chi-Fu, additional, and Asamura, Hisao, additional

Published
2023
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39. The IASLC Thymic Epithelial Tumors Staging Project: Proposals for the N and the M Components for the Forthcoming (9th) Edition of the TNM Classification of Malignant Tumors

Author

Fang, Wentao, primary, Girard, Nicolas, additional, Cilento, Vanessa, additional, Goren, Emily, additional, Dibaba, Daniel, additional, Ruffini, Enrico, additional, Ahmad, Usman, additional, Appel, Sarit, additional, Bille, Andrea, additional, Boubia, Souheil, additional, Brambilla, Cecilia, additional, Cangir, Ayten Kayi, additional, Detterbeck, Frank, additional, Falkson, Conrad, additional, Filosso, Pier Luigi, additional, Giaccone, Giuseppe, additional, Guerrera, Francesco, additional, Huang, James, additional, Infante, Maurizio, additional, Kim, Dong Kwan, additional, Lucchi, Marco, additional, Marino, Mirella, additional, Marom, Edith M., additional, Nicholson, Andrew G., additional, Okumura, Meinoshin, additional, Rami-Porta, Ramon, additional, Rimner, Andreas, additional, Simone, Charles B., additional, and Asamura, Hisao, additional

Published
2023
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41. Salvage surgery for recurrent transdiaphragmatic thymoma in a patient not eligible for chemotherapy.

Author

Fabbri, Giulia, Berjaoui, Nabih, Lampridis, Savvas, Bilkhu, Rajdeep, Chauhan, Ishaan, Kew, Ee Phui, Patel, Akshay, and Bille, Andrea

Subjects
THYMOMA, THORACIC vertebrae, SURGERY, CANCER chemotherapy, TUMOR surgery, OVERALL survival
Abstract

The recurrence rate following thymoma surgery has been reported to be as high as 29%. In cases of localized recurrence, complete resection can result in prolonged patient survival. However, surgery is rarely considered in cases of invasive recurrent thymomas with high disease burden. Here, we present the case of a woman with type B2 thymoma (Masaoka–Koga stage IVa) treated with surgery, chemotherapy, and radiotherapy. The disease recurred 6 years later, with invasion of the left lung and the 12th thoracic vertebra, as well as extension into the retroperitoneum. Due to the development of chemotherapy-associated toxicity, she underwent surgery with complete tumor resection and has remained free of disease at a 12-months follow-up. Radical surgery for recurrent invasive thymoma extending through the diaphragm is a feasible and safe therapeutic option in highly selected patients who are not eligible for systemic treatments. [ABSTRACT FROM AUTHOR]

Published
2024
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42. European Epidemiology of Pleural Mesothelioma—Real-Life Data From a Joint Analysis of the Mesoscape Database of the European Thoracic Oncology Platform and the European Society of Thoracic Surgery Mesothelioma Database

Author

Opitz, Isabelle, primary, Bille, Andrea, additional, Dafni, Urania, additional, Nackaerts, Kristiaan, additional, Ampollini, Luca, additional, de Perrot, Marc, additional, Brcic, Luka, additional, Nadal, Ernest, additional, Syrigos, Konstantinos, additional, Gray, Steven G., additional, Aerts, Joachim, additional, Curioni-Fontecedro, Alessandra, additional, Rüschoff, Jan H., additional, Monkhorst, Kim, additional, Weynand, Birgit, additional, Silini, Enrico Maria, additional, Bavaghar-Zaeimi, Fatemeh, additional, Jakopovic, Marko, additional, Llatjos, Roger, additional, Tsimpoukis, Sotirios, additional, Finn, Stephen P., additional, von der Thüsen, Jan, additional, Marti, Nesa, additional, Dimopoulou, Georgia, additional, Kammler, Roswitha, additional, Peters, Solange, additional, Stahel, Rolf A., additional, Falcoz, Pierre-Emmanuel, additional, Brunelli, Alessandro, additional, Baas, Paul, additional, Stahel, Rolf, additional, Hiltbrunner, Anita, additional, Kammler, Rosita, additional, Ruepp, Barbara, additional, Tsourti, Zoi, additional, Zygoura, Panagiota, additional, Vervita, Katerina, additional, Andriakopoulou, Charitini, additional, Stavrou, Androniki, additional, Haberecker, Martina, additional, Dettwiler, Susanne, additional, Prutek, Fabiola, additional, Mittmann, Christiane, additional, Opitz, Isabelle, additional, Vrugt, Bart, additional, Friess, Martina, additional, Matter, Alessandra, additional, Spichiger-Häusermann, Chloé, additional, Kirschner, Michaela B., additional, Felley-Bosco, Emanuela, additional, Verbeken, Eric, additional, Nafteux, Philippe, additional, Moons, Johnny, additional, Peeters, Liesbet, additional, Tiseo, Marcello, additional, Gnetti, Letizia, additional, Carbognani, Paolo, additional, Samarzija, Miroslav, additional, Seiwerth, Sven, additional, Cardenal, Felipe, additional, Lorente, Susana, additional, Vamvakaris, Ioannis, additional, Boura, Paraskevi, additional, Nur, Mutaz Mohammed, additional, Baird, Anne-Marie, additional, Barr, Martin P., additional, Cuffe, Sinead, additional, Gately, Kathy, additional, Thüsen, Jan von der, additional, and Passani, Stefano, additional

Published
2023
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45. The International Association for the Study of Lung Cancer Lung Cancer Staging Project: Overview of Challenges and Opportunities in Revising the Nodal Classification of Lung Cancer

Author

Osarogiagbon, Raymond Uyiosa, primary, Van Schil, Paul, additional, Giroux, Dorothy J., additional, Lim, Eric, additional, Putora, Paul Martin, additional, Lievens, Yolande, additional, Cardillo, Giuseppe, additional, Kim, Hong Kwan, additional, Rocco, Gaetano, additional, Bille, Andrea, additional, Prosch, Helmut, additional, Vásquez, Francisco Suárez, additional, Nishimura, Katherine K., additional, Detterbeck, Frank, additional, Rami-Porta, Ramon, additional, Rusch, Valerie W., additional, Asamura, Hisao, additional, and Huang, James, additional

Published
2023
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47. MARS 2: Extended Pleurectomy Decortication and Chemotherapy for Pleural Mesothelioma

Author

Lim, Eric, primary, Waller, David, additional, Lau, Kelvin, additional, Steele, Jeremy, additional, Pope, Anthony, additional, Ali, Clinton, additional, Bilancia, Rocco, additional, Keni, Manjusha, additional, Popat, Sanjay, additional, O&apos;Brien, Mary, additional, Tokaca, Nadza, additional, Maskell, Nick, additional, Stadon, Louise, additional, Fennell, Dean, additional, Nelson, Louise, additional, Edwards, John, additional, Tenconi, Sara, additional, Socci, Laura, additional, Rintoul, Robert, additional, Wood, Kelly, additional, Stone, Amanda, additional, Muthukumar, Dakshinamoorthy, additional, Ingle, Charlotte, additional, Taylor, Paul, additional, Cove-Smith, Laura, additional, Califano, Raffaele, additional, Summers, Yvonne, additional, Tasigiannopoulos, Zacharias, additional, Bille, Andrea, additional, Shah, Riyaz, additional, Fuller, Elizabeth, additional, Macnair, Andrew, additional, Shamash, Jonathan, additional, Mansy, Talal, additional, Milton, Richard, additional, Koh, Pek, additional, Ionescu, Alina, additional, Treece, Sarah, additional, Roy, Amy, additional, Middleton, Gary, additional, Kirk, Alan J. B., additional, Harris, Rosie A, additional, Ashton, Kate, additional, Warnes, Barbara, additional, Bridgeman, Emma, additional, Joyce, Katherine, additional, Mills, Nicola, additional, Elliott, Daisy, additional, Farrar, Nicola, additional, Stokes, Elizabeth, additional, Hughes, Vikki, additional, Nicholson, Andrew, additional, Rogers, Chris, additional, and Investigators, anon, additional

Published
2023
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50. Multimodality Treatment and Salvage Surgery for the Treatment of Lung Cancer.

Author

Choi, Jeesoo, Tocco, Boris, Smith, Alexander, Ahmad, Shahreen, Josephides, Eleni, and Bille, Andrea

Subjects
RESEARCH methodology, LUNG tumors, RETROSPECTIVE studies, PEARSON correlation (Statistics), CHI-squared test, DECISION making, SALVAGE therapy, COMBINED modality therapy, PROGRESSION-free survival, IMMUNOTHERAPY, OVERALL survival
Abstract

Simple Summary: There is a broad variety of treatment options for lung cancer, which include medical therapy and surgical resection. Opinion varies as to the optimal treatment options and combinations in different contexts of the disease, which has an impact on the prognosis of the disease—relapse and survival. This is a descriptive study on patients who underwent multimodality therapy (a combination of chemotherapy, radiotherapy and surgical resection) and an evaluation of patient and disease characteristics that may have an impact on the treatment pathway. Lung cancer remains the leading cause of cancer deaths in the United Kingdom. For locally advanced disease, multimodality treatment is recommended, which includes a combination of chemotherapy, radiotherapy, surgery and, more recently immunotherapy. Options depend on the resectability of the cancer and there has been debate about the optimal treatment strategy: surgery may be planned to follow chemoradiotherapy (CRT), be offered for residual disease after CRT, or given as salvage therapy for patients treated with CRT who have later relapse of their disease. We conducted a retrospective analysis of all patients who underwent CRT and surgical resection under a single surgical team and performed a descriptive study after dividing the patients into these three groups. For the planned trimodality group, 30-day mortality this was 7% (n = 1) and 1-year survival was 78.6%; the residual disease group had a 30-day mortality rate of 0% and 1-year survival of 81.3%; for the salvage group, the figures were 0% and 62.5%, respectively. The median overall survival of the study population was 35.8 months. Median overall survival in the trimodality group was 35.4 months (20.1–51.7 interquartile range IQR), for the residual group was 34.2 months (18.5–61.0 IQR). and for the salvage group was 35.8 months (32.4–52.7 IQR).) [ABSTRACT FROM AUTHOR]

Published
2023
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