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165 results on '"Biliotti, Elisa"'

1. A holistic evaluation of patients with chronic Hepatitis D virus (HDV) infection enrolled in the Italian PITER-B and delta cohort

Author

Aghemo, Alessio, Baiguera, Chiara, Battezzati, Pier Maria, Battistella, Sara, Bavetta, Maria Grazia, Bertoni, Costanza, Boni, Carolina, Brambilla, Paola, Bray, Antonella, Briano, Federica, Carmenini, Enrico, Castelli, Francesco, Cavalletto, Luisa, Cerini, Federica, Chidichimo, Luciana, Colella, Elisa, Cologni, Giuliana, Como, Silvia, Corsini, Romina, Costa, Chiara, Cotugno, Rosa, Cretella, Silvia, De Angelis, Fernando, De Leo, Pasqualina, Perri, Giovanni Di, Falbo, Elisabetta, Ferrigno, Luigina, Fornasiere, Ezio, Francisci, Daniela, Gatti, Pietro, Lampertico, Pietro, Lenci, Ilaria, Licata, Anna, Maida, Ivana, Marzano, Alfredo, Mastroianni, Antonio, Mazzaro, Cesare, Monti, Monica, Nardone, Gerardo, Nicolini, Laura Ambra, Passigato, Nicola, Pasticci, Maria Bruna, Pierotti, Piera, Pinchera, Biagio, Pollicino, Teresa, Porcu, Carmen, Quartini, Giulia, Rancatore, Gabriele, Romeo, Mario, Rumi, Maria Grazia, Saracino, Annalisa, Schioppa, Ornella, Serio, Ilaria, Soffredini, Roberta, Tata, Xhimi, Tizzani, Marco, Tonnini, Matteo, Torti, Carlo, Valenti, Daniela, Zaltron, Serena, Zoncada, Alessia, Kondili, Loreta A., Brancaccio, Giuseppina, Tosti, Maria Elena, Coco, Barbara, Quaranta, Maria Giovanna, Messina, Vincenzo, Ciancio, Alessia, Morisco, Filomena, Cossiga, Valentina, Claar, Ernesto, Rosato, Valerio, Ciarallo, Marianna, Cacciola, Irene, Ponziani, Francesca Romana, Cerrito, Lucia, Coppola, Roberta, Longobardi, Francesco, Biliotti, Elisa, Rianda, Alessia, Barbaro, Francesco, Coppola, Nicola, Stanzione, Maria, Barchiesi, Francesco, Fagiuoli, Stefano, Viganò, Mauro, Massari, Marco, Russo, Francesco Paolo, Ferrarese, Alberto, Laccabue, Diletta, Di Marco, Vito, Blanc, Pierluigi, Marrone, Aldo, Morsica, Giulia, Federico, Alessandro, Ieluzzi, Donatella, Rocco, Alba, Foschi, Francesco Giuseppe, Soria, Alessandro, Chessa, Luchino, Milella, Michele, Rosselli Del Turco, Elena, Madonia, Salvatore, Chemello, Liliana, Gentile, Ivan, Toniutto, Pierluigi, Bassetti, Matteo, Surace, Lorenzo, Baiocchi, Leonardo, Pellicelli, Adriano, De Santis, Adriano, Puoti, Massimo, Degasperi, Elisabetta, Niro, Grazia Anna, Zignego, Anna Linda, Craxi, Antonio, Raimondo, Giovanni, Santantonio, Teresa Antonia, Brunetto, Maurizia Rossana, and Gaeta, Giovanni Battista

Published
2024
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2. Profiling the risk of hepatocellular carcinoma after long-term HCV eradication in patients with liver cirrhosis in the PITER cohort

Author

Panetta, Valentina, Gaeta, Giovanni Battista, Filomia, Roberto, Coco, Barbara, Monti, Monica, Amoruso, Daniela Caterina, Madonia, Salvatore, Ieluzzi, Donatella, Taliani, Gloria, Badia, Lorenzo, Migliorino, Guglielmo Marco, Giorgini, Alessia, Masarone, Mario, Blanc, Pierluigi, Cossiga, Valentina, De Siena, Martina, Tata, Xhimi, Rumi, Maria Grazia, Chessa, Luchino, Lampertico, Pietro, Ferrari, Carlo, Gentile, Ivan, Parruti, Giustino, Baiocchi, Leonardo, Ciancio, Alessia, Invernizzi, Pietro, Federico, Alessandro, Torti, Carlo, Morsica, Giulia, Andreone, Pietro, Aghemo, Alessio, Popoli, Patrizia, Vella, Stefano, Kondili, Loreta A., Quaranta, Maria Giovanna, Cavalletto, Luisa, Calvaruso, Vincenza, Ferrigno, Luigina, D'Ambrosio, Roberta, Simonelli, Ilaria, Brancaccio, Giuseppina, Raimondo, Giovanni, Brunetto, Maurizia R., Zignego, Anna Linda, Coppola, Carmine, Iannone, Andrea, Biliotti, Elisa, Verucchi, Gabriella, Massari, Marco, Licata, Anna, Barbaro, Francesco, Persico, Marcello, Russo, Francesco Paolo, Morisco, Filomena, Pompili, Maurizio, Viganò, Mauro, Puoti, Massimo, Santantonio, Teresa, Villa, Erica, Craxì, Antonio, and Chemello, Liliana

Published
2023
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3. SARS-CoV-2 nasopharyngeal viral load in individuals infected with BA.2, compared to Alpha, Gamma, Delta and BA.1 variants: A single-center comparative analysis

Author

Mastrorosa, Ilaria, Cozzi-Lepri, Alessandro, Colavita, Francesca, Lalle, Eleonora, Mazzotta, Valentina, Cimaglia, Claudia, Paulicelli, Jessica, Matusali, Giulia, Fabeni, Lavinia, Carletti, Fabrizio, Rosati, Silvia, Vita, Serena, Giannico, Giuseppina, Piselli, Pierluca, Biliotti, Elisa, Moghazi, Samir Al, Mosti, Silvia, Girardi, Enrico, Nicastri, Emanuele, Garbuglia, Anna Rosa, Maggi, Fabrizio, Vaia, Francesco, and Antinori, Andrea

Published
2022
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4. Exploring Predictive Factors for Bulevirtide Treatment Response in Hepatitis Delta-Positive Patients.

Author

Zulian, Verdiana, Salichos, Leonidas, Taibi, Chiara, Pauciullo, Silvia, Dong, Levi, D'Offizi, Gianpiero, Biliotti, Elisa, Rianda, Alessia, Federici, Luigi, Bibbò, Angela, De Sanctis, Martina, McPhee, Fiona, and Garbuglia, Anna Rosa

Subjects
HEPATITIS D virus, GENETIC variation, VIRAL hepatitis, AMINO acid sequence, RNA analysis
Abstract

Background: Hepatitis delta virus (HDV) infection represents the most severe form of viral hepatitis and is a significant global health challenge. Bulevirtide (BLV) is a novel therapeutic treatment that has resulted in variable response rates in HBV/HDV-coinfected patients. We evaluated clinical, virological, and polymorphic factors for the purpose of predicting BLV treatment success. Methods: Thirty HBV/HDV-coinfected patients received BLV monotherapy (2 mg/day) for 24 to 48 weeks. Baseline (BL) serum samples were collected to assess clinical parameters and virological markers (HDV RNA, HBV DNA, HBsAg, HBcrAg, anti-HBc IgG) at treatment weeks 24 (TW24) and 48 (TW48). Additionally, full-genome HDV sequencing and a phylogenetic analysis were performed. Finally, analyses of the HDAg protein sequence and HDV RNA secondary structure were conducted to evaluate potential associations with treatment response. Results: A significant reduction in HDV RNA levels was observed at TW48, with a virological response (HDV RNA undetectable or ≥2 Log decline from BL) achieved by 58% of patients. Median BL levels of anti-HBc IgG were significantly different between virological responders (39.3 COI; interquartile range [IQR] 31.6–47.1) and virological non-responders (244.7 COI; IQR 127.0–299.4) (p = 0.0001). HDV genotype 1e was predominant across the cohort, and no specific HDAg polymorphisms predicted the response. However, secondary structure analysis of HDV RNA revealed that a specific pattern of internal loops in the region 63–100 nucleotides downstream of the editing site may influence treatment response by impacting editing efficacy. Conclusions: This study revealed key factors influencing BLV efficacy in HBV/HDV coinfection. Lower baseline anti-HBc IgG levels strongly correlated with a positive virological response, suggesting that the liver's inflammatory state affects treatment success. Additionally, the analysis of HDV RNA secondary structure in patients receiving BLV treatment revealed a higher editing efficiency in virological responders, highlighting areas for further research. [ABSTRACT FROM AUTHOR]

Published
2025
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5. Clinical features and comorbidity pattern of HCV infected migrants compared to native patients in care in Italy: A real-life evaluation of the PITER cohort

Author

Mazzaro, Cesare, Bertola, Manuela, Schioppa, Ornella, Benedetti, Antonio, Schiadà, Laura, Cucco, Monica, Giacometti, Andrea, Brescini, Laura, Castelletti, Sefora, Fiorentini, Alessandro, Angarano, Gioacchino, Milella, Michele, Di Leo, Alfredo, Rendina, Maria, D'abramo, Fulvio Salvatore, Lillo, Chiara, Iannone, Andrea, Piazzolla, Mariano, Verucchi, Gabriella, Badia, Lorenzo, Piscaglia, Fabio, Benevento, Francesca, Serio, Ilaria, Castelli, Francesco, Zaltron, Serena, Spinetti, Angiola, Odolini, Silvia, Bruno, Raffaele, Mondelli, Mario, Chessa, Luchino, Loi, Martina, Torti, Carlo, Costa, Chiara, Mazzitelli, Maria, Pisani, Vincenzo, Scaglione, Vincenzo, Trecarichi, Enrico Maria, Zignego, Anna Linda, Monti, Monica, Madia, Francesco, Blanc, Pier Luigi, Attala, Letizia, Pierotti, Piera, Salomoni, Elena, Mariabelli, Elisa, Santantonio, Teresa Antonia, Bruno, Serena Rita, Cela, Ester Marina, Bassetti, Matteo, Mazzarello, Giovanni, Alessandrini, Anna Ida, Di Biagio, Antonio, Nicolini, Laura Ambra, Raimondo, Giovanni, Filomia, Roberto, Aghemo, Alessio, Meli, Rossella, Lazzarin, Adriano, Morsica, Giulia, Salpietro, Stefania, Galli, Massimo, Fracanzani, Anna Ludovica, Fatta, Erika, Lombardi, Rosa, Lampertico, Pietro, Borghi, Marta, D'ambrosio, Roberta, Degasperi, Elisabetta, Puoti, Massimo, Baiguera, Chiara, D'amico, Federico, Vinci, Maria, Rumi, Maria Grazia, Zuin, Massimo, Giorgini, Alessia, Zermiani, Paola, Andreone, Pietro, Caraceni, Paolo, Margotti, Marzia, Guarneri, Valeria, Villa, Erica, Bernabucci, Veronica, Bristot, Laura, Paradiso, Maria Luisa, Migliorino, Guglielmo, Beretta, Ilaria, Gambaro, Alessandra, Lapadula, Giuseppe, Spolti, Anna, Soria, Alessandro, Invernizzi, Pietro, Ciaccio, Antonio, LucÀ, Martina, Malinverno, Federica, Ratti, Laura, Coppola, Carmine, Amoruso, Daniela Caterina, Pisano, Federica, Scarano, Ferdinando, Staiano, Laura, Morisco, Filomena, Cossiga, Valentina, Gentile, Ivan, Buonomo, Antonio Riccardo, Foggia, Maria, Zappulo, Emanuela, Federico, Alessandro, Dallio, Marcello, Coppola, Nicola, Sagnelli, Caterina, Martini, Salvatore, Monari, Caterina, Nardone, Gerardo, Sgamato, Costantino, Chemello, Liliana, Cavalletto, Luisa, Sterrantino, Daniela, Russo, Francesco Paolo, Zanetto, Alberto, Zanaga, Paola, Barbaro, Francesco, Brancaccio, Giuseppina, Craxì, Antonio, Petta, Salvatore, Calvaruso, Vincenza, Crapanzano, Luciano, Madonia, Salvatore, Cannizzaro, Marco, Bruno, Erica Maria, Licata, Anna, Amodeo, Simona, Capitano, Adele Rosaria, Ferrari, Carlo, Laccabue, Diletta, Negri, Elisa, Orlandini, Alessandra, Pesci, Marco, Gulminetti, Roberto, Pagnucco, Layla, Parruti, Giustino, Di Stefano, Paola, Brunetto, Maurizia Rossana, Coco, Barbara, Massari, Marco, Corsini, Romina, Garlassi, Elisa, Andreoni, Massimo, Teti, Elisabetta, Cerva, Carlotta, Baiocchi, Lorenzo, Tata, Xhimi, Grassi, Giuseppe, Gasbarrini, Antonio, Pompili, Maurizio, De Siena, Martina, Taliani, Gloria, Biliotti, Elisa, Spaziante, Martina, Persico, Marcello, Masarone, Mario, Aglitti, Andrea, Calvanese, Gemma, Anselmo, Marco, De Leo, Pasqualina, Marturano, Monica, Saracco, Giorgio Maria, Ciancio, Alessia, Ieluzzi, Donatella, Quaranta, Maria Giovanna, Ferrigno, Luigina, D'Angelo, Franca, Saracino, Annalisa, and Kondili, Loeta A.

Published
2021
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7. A holistic evaluation of patients with chronic Hepatitis D virus (HDV) infection enrolled in the Italian PITER-B and Delta cohort

Author

Kondili, Loreta A., primary, Brancaccio, Giuseppina, additional, Tosti, Maria Elena, additional, Coco, Barbara, additional, Quaranta, Maria Giovanna, additional, Messina, Vincenzo, additional, Ciancio, Alessia, additional, Morisco, Filomena, additional, Cossiga, Valentina, additional, Claar, Ernesto, additional, Rosato, Valerio, additional, Ciarallo, Marianna, additional, Cacciola, Irene, additional, Ponziani, Francesca Romana, additional, Cerrito, Lucia, additional, Coppola, Roberta, additional, Longobardi, Francesco, additional, Biliotti, Elisa, additional, Rianda, Alessia, additional, Barbaro, Francesco, additional, Coppola, Nicola, additional, Stanzione, Maria, additional, Barchiesi, Francesco, additional, Fagiuoli, Stefano, additional, Viganò, Mauro, additional, Massari, Marco, additional, Russo, Francesco Paolo, additional, Ferrarese, Alberto, additional, Laccabue, Diletta, additional, Marco, Vito Di, additional, Blanc, Pierluigi, additional, Marrone, Aldo, additional, Morsica, Giulia, additional, Federico, Alessandro, additional, Ieluzzi, Donatella, additional, Rocco, Alba, additional, Foschi, Francesco Giuseppe, additional, Soria, Alessandro, additional, Maida, Ivana, additional, Chessa, Luchino, additional, Milella, Michele, additional, Turco, Elena Rosselli del, additional, Madonia, Salvatore, additional, Chemello, Liliana, additional, Gentile, Ivan, additional, Toniutto, Pierluigi, additional, Bassetti, Matteo, additional, Surace, Lorenzo, additional, Baiocchi, Leonardo, additional, Pellicelli, Adriano, additional, De Santis, Adriano, additional, Puoti, Massimo, additional, Degasperi, Elisabetta, additional, Niro, Grazia Anna, additional, Zignego, Anna Linda, additional, Craxi, Antonio, additional, Raimondo, Giovanni, additional, Santantonio, Teresa Antonia, additional, Brunetto, Maurizia Rossana, additional, Gaeta, Giovanni Battista, additional, and Investigators, on behalf of PITER Collaborating, additional

Published
2024
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8. Reduction of the Risk of Hepatocellular Carcinoma over Time Using Direct-Acting Antivirals: A Propensity Score Analysis of a Real-Life Cohort (PITER HCV).

Author

Quaranta, Maria Giovanna, Cavalletto, Luisa, Russo, Francesco Paolo, Calvaruso, Vincenza, Ferrigno, Luigina, Zanetto, Alberto, Mattioli, Benedetta, D'Ambrosio, Roberta, Panetta, Valentina, Brancaccio, Giuseppina, Raimondo, Giovanni, Brunetto, Maurizia Rossana, Zignego, Anna Linda, Coppola, Carmine, Iannone, Andrea, Biliotti, Elisa, Rosselli Del Turco, Elena, Massari, Marco, Licata, Anna, and Barbaro, Francesco

Subjects
HEPATOCELLULAR carcinoma, ANTIVIRAL agents, HEPATITIS C virus, COHORT analysis, VIRAL hepatitis
Abstract

The treatment of hepatitis C virus (HCV) with direct-acting antivirals (DAA) leads to high sustained virological response (SVR) rates, but hepatocellular carcinoma (HCC) risk persists in people with advanced liver disease even after SVR. We weighted the HCC risk in people with cirrhosis achieving HCV eradication through DAA treatment and compared it with untreated participants in the multicenter prospective Italian Platform for the Study of Viral Hepatitis Therapies (PITER) cohort. Propensity matching with inverse probability weighting was used to compare DAA-treated and untreated HCV-infected participants with liver cirrhosis. Kaplan–Meier analysis and competing risk regression analysis were performed. Within the first 36 months, 30 de novo HCC cases occurred in the untreated group (n = 307), with a weighted incidence rate of 0.34% (95%CI: 0.23–0.52%), compared to 63 cases among SVR patients (n = 1111), with an incidence rate of 0.20% (95%CI: 0.16–0.26%). The 12-, 24-, and 36-month HCC weighted cumulative incidence rates were 6.7%, 8.4%, and 10.0% in untreated cases and 2.3%, 4.5%, and 7.0% in the SVR group. Considering death or liver transplantation as competing events, the untreated group showed a 64% higher risk of HCC incidence compared to SVR patients (SubHR 1.64, 95%CI: 1.02–2.62). Other variables independently associated with the HCC occurrence were male sex, increasing age, current alcohol use, HCV genotype 3, platelet count ≤ 120,000/µL, and albumin ≤ 3.5 g/dL. In real-life practice, the high efficacy of DAA in achieving SVR is translated into high effectiveness in reducing the HCC incidence risk. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Profiling the risk of hepatocellular carcinoma after long-term HCV eradication in patients with liver cirrhosis in the PITER cohort

Author

Kondili, Loreta A., primary, Quaranta, Maria Giovanna, additional, Cavalletto, Luisa, additional, Calvaruso, Vincenza, additional, Ferrigno, Luigina, additional, D'Ambrosio, Roberta, additional, Simonelli, Ilaria, additional, Brancaccio, Giuseppina, additional, Raimondo, Giovanni, additional, Brunetto, Maurizia R., additional, Zignego, Anna Linda, additional, Coppola, Carmine, additional, Iannone, Andrea, additional, Biliotti, Elisa, additional, Verucchi, Gabriella, additional, Massari, Marco, additional, Licata, Anna, additional, Barbaro, Francesco, additional, Persico, Marcello, additional, Russo, Francesco Paolo, additional, Morisco, Filomena, additional, Pompili, Maurizio, additional, Viganò, Mauro, additional, Puoti, Massimo, additional, Santantonio, Teresa, additional, Villa, Erica, additional, Craxì, Antonio, additional, Chemello, Liliana, additional, Panetta, Valentina, additional, Gaeta, Giovanni Battista, additional, Filomia, Roberto, additional, Coco, Barbara, additional, Monti, Monica, additional, Amoruso, Daniela Caterina, additional, Madonia, Salvatore, additional, Ieluzzi, Donatella, additional, Taliani, Gloria, additional, Badia, Lorenzo, additional, Migliorino, Guglielmo Marco, additional, Giorgini, Alessia, additional, Masarone, Mario, additional, Blanc, Pierluigi, additional, Cossiga, Valentina, additional, De Siena, Martina, additional, Tata, Xhimi, additional, Rumi, Maria Grazia, additional, Chessa, Luchino, additional, Lampertico, Pietro, additional, Ferrari, Carlo, additional, Gentile, Ivan, additional, Parruti, Giustino, additional, Baiocchi, Leonardo, additional, Ciancio, Alessia, additional, Invernizzi, Pietro, additional, Federico, Alessandro, additional, Torti, Carlo, additional, Morsica, Giulia, additional, Andreone, Pietro, additional, Aghemo, Alessio, additional, Popoli, Patrizia, additional, and Vella, Stefano, additional

Published
2023
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10. Impaired flow-mediated dilation in hospitalized patients with community-acquired pneumonia

Author

Loffredo, Lorenzo, Cangemi, Roberto, Perri, Ludovica, Catasca, Elisa, Calvieri, Camilla, Carnevale, Roberto, Nocella, Cristina, Equitani, Francesco, Ferro, Domenico, Violi, Francesco, Battaglia, Simona, Bertazzoni, Giuliano, Biliotti, Elisa, Bucci, Tommaso, Calabrese, Cinzia Myriam, Casciaro, Marco, Celestini, Andrea, De Angelis, Maurizio, De Marzio, Paolo, Esvan, Rozenn, Falcone, Marco, Fazi, Lucia, Sulekova, Lucia Fontanelli, Franchi, Cristiana, Giordo, Laura, Grieco, Stefania, Manzini, Elisa, Marinelli, Paolo, Mordenti, Michela, Morelli, Sergio, Palange, Paolo, Pastori, Daniele, Pignatelli, Pasquale, Capparuccia, Marco Rivano, Romiti, Giulio Francesco, Rossi, Elisabetta, Ruscio, Eleonora, Russo, Alessandro, Scarpellini, Maria Gabriella, Solimando, Luisa, Taliani, Gloria, Trapè, Stefano, and Toriello, Filippo

Published
2016
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11. Low-grade endotoxemia, gut permeability and platelet activation in community-acquired pneumonia

Author

Battaglia, Simona, Bertazzoni, Giuliano, Biliotti, Elisa, Calabrese, Cinzia Myriam, Casciaro, Marco, De Angelis, Maurizio, De Marzio, Paolo, Esvan, Rozenn, Fazi, Lucia, Ferro, Domenico, Fontanelli Sulekova, Lucia, Franchi, Cristiana, Giordo, Laura, Grieco, Stefania, Manzini, Elisa, Morelli, Sergio, Palange, Paolo, Pastori, Daniele, Rivano Capparuccia, Marco, Romiti, Giulio Francesco, Rossi, Elisabetta, Ruscio, Eleonora, Russo, Alessandro, Scarpellini, Maria Gabriella, Trapè, Stefano, Toriello, Filippo, Cangemi, Roberto, Pignatelli, Pasquale, Carnevale, Roberto, Bartimoccia, Simona, Nocella, Cristina, Falcone, Marco, Taliani, Gloria, and Violi, Francesco

Published
2016
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12. Predicting de‐novoportal vein thrombosis after HCV eradication: A long‐term competing risk analysis in the ongoing PITER cohort

Author

Kondili, Loreta A., Zanetto, Alberto, Quaranta, Maria Giovanna, Ferrigno, Luigina, Panetta, Valentina, Calvaruso, Vincenza, Zignego, Anna Linda, Brunetto, Maurizia R., Raimondo, Giovanni, Biliotti, Elisa, Ieluzzi, Donatella, Iannone, Andrea, Madonia, Salvatore, Chemello, Liliana, Cavalletto, Luisa, Coppola, Carmine, Morisco, Filomena, Barbaro, Francesco, Licata, Anna, Federico, Alessandro, Cerini, Federica, Persico, Marcello, Pompili, Maurizio, Ciancio, Alessia, Piscaglia, Fabio, Chessa, Luchino, Giacometti, Andrea, Invernizzi, Pietro, Brancaccio, Giuseppina, Benedetti, Antonio, Baiocchi, Leonardo, Gentile, Ivan, Coppola, Nicola, Nardone, Gerardo, Craxì, Antonio, Russo, Francesco Paolo, Monti, Monica, Coco, Barbara, Filomia, Roberto, Bruno, Erica Maria, Cossiga, Valentina, Amodeo, Simona, Dallio, Marcello, Crapanzano, Luciano, Masarone, Mario, De Siena, Martina, Serio, Ilaria, Loi, Martina, Brescini, Lucia, Ciaccio, Antonio, Cucco, Monica, Tata, Xhimi, Sagnelli, Caterina, Sgamato, Costantino, Claar, Ernesto, Rosselli Del Turco, Elena, Rumi, Maria Grazia, Gaeta, Giovanni Battista, and Simioni, Paolo

Abstract

Sustained virological response (SVR) by direct‐acting antivirals (DAAs) may reverse the hypercoagulable state of HCV cirrhosis and the portal vein thrombosis (PVT) risk. We evaluated the incidence and predictive factors of de novo, non‐tumoral PVT in patients with cirrhosis after HCV eradication. Patients with HCV‐related cirrhosis, consecutively enrolled in the multi‐center ongoing PITER cohort, who achieved the SVR using DAAs, were prospectively evaluated. Kaplan‐Meier and competing risk regression analyses were performed. During a median time of 38.3 months (IQR: 25.1–48.7 months) after the end of treatment (EOT), among 1609 SVR patients, 32 (2.0%) developed de novo PVT. A platelet count ≤120,000/μL, albumin levels ≤3.5 mg/dL, bilirubin >1.1 mg/dL, a previous liver decompensation, ALBI, Baveno, FIB‐4, and RESIST scores were significantly different (p< 0.001), among patients who developed PVT versus those who did not. Considering death and liver transplantation as competing risk events, esophageal varices (subHR: 10.40; CI 95% 4.33–24.99) and pre‐treatment ALBI grade ≥2 (subHR: 4.32; CI 95% 1.36–13.74) were independent predictors of PVT. After HCV eradication, a significant variation in PLT count, albumin, and bilirubin (p< 0.001) versus pre‐treatment values was observed in patients who did not develop PVT, whereas no significant differences were observed in those who developed PVT (p> 0.05). After the EOT, esophageal varices and ALBI grade ≥2, remained associated with de novo PVT (subHR: 9.32; CI 95% 3.16–27.53 and subHR: 5.50; CI 95% 1.67–18.13, respectively). In patients with HCV‐related cirrhosis, a more advanced liver disease and significant portal hypertension are independently associated with the de novo PVT risk after SVR.

Published
2024
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14. Epidemiological and clinical profile of HDV infected people in care in Italy: interim analysis from the ongoing PITER cohort

Author

Kondili, Loreta, primary, Tosti, Maria Elena, additional, Quaranta, Maria Giovanna, additional, Ciancio, Alessia, additional, Messina, Vincenzo, additional, Brancaccio, Giuseppina, additional, Brunetto, Maurizia, additional, Capasso, Mario, additional, Rosato, Valerio, additional, Cacciola, Irene, additional, Pasulo, Luisa, additional, Santantonio, Teresa, additional, Coppola, Carmine, additional, Biliotti, Elisa, additional, Barbaro, Francesco, additional, Massari, Marco, additional, Coppola, Nicola, additional, Ferrarese, Alberto, additional, Russo, Francesco Paolo, additional, Di Marco, Vito, additional, Marrone, Aldo, additional, Schivazappa, Simona, additional, Federico, Alessandro, additional, Blanc, Pierluigi, additional, Rocco, Alba, additional, Morsica, Giulia, additional, Ieluzzi, Donatella, additional, Conti, Fabio, additional, De Siena, Martina, additional, Bavetta, Maria Grazia, additional, Milella, Michele, additional, Gentile, Ivan, additional, Porcu, Carmen, additional, Chemello, Liliana, additional, Maracci, Monia, additional, Zignego, Anna Linda, additional, Baiocchi, Leonardo, additional, Maida, Ivana Rita, additional, and Coco, Barbara, additional

Published
2023
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15. Evolution of SARS‐CoV‐2 variants of concern over a period of Delta and Omicron cocirculation, among patients hospitalized for COVID‐19 in an Italian reference hospital: Impact on clinical outcomes

Author

Mondi, Annalisa, primary, Mastrorosa, Ilaria, additional, Piselli, Pierluca, additional, Cimaglia, Claudia, additional, Matusali, Giulia, additional, Carletti, Fabrizio, additional, Giannico, Giuseppina, additional, Milozzi, Eugenia, additional, Biliotti, Elisa, additional, Di Bari, Silvia, additional, Chinello, Pierangelo, additional, Beccacece, Alessia, additional, Faraglia, Francesca, additional, Vittozzi, Pietro, additional, Mosti, Silvia, additional, Tetaj, Nardi, additional, Stazi, Giulia Valeria, additional, Pinnetti, Carmela, additional, Camici, Marta, additional, D'Annunzio, Alberto, additional, Marani, Alessandra, additional, Fabeni, Lavinia, additional, Specchiarello, Eliana, additional, Gruber, Cesare Ernesto Maria, additional, Villanacci, Alberta, additional, Minicucci, Sabrina, additional, Garbuglia, Anna Rosa, additional, Ianniello, Stefania, additional, Marchioni, Luisa, additional, Taglietti, Fabrizio, additional, D'Offizi, Gianpiero, additional, Palmieri, Fabrizio, additional, Nicastri, Emanuele, additional, Maggi, Fabrizio, additional, Vaia, Francesco, additional, Girardi, Enrico, additional, and Antinori, Andrea, additional

Published
2023
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17. Relation of Cardiac Complications in the Early Phase of Community-Acquired Pneumonia to Long-Term Mortality and Cardiovascular Events

Author

Battaglia, Simona, Biliotti, Elisa, Calabrese, Cinzia M., Casciaro, Marco, De Angelis, Maurizio, De Marzio, Paolo, Esvan, Rozenn, Fazi, Lucia, Sulekova, Lucia F., Franchi, Cristiana, Giordo, Laura, Grieco, Stefania, Manzini, Elisa, Marinelli, Paolo, Mordenti, Michela, Morelli, Sergio, Palange, Paolo, Pastori, Daniele, Pignatelli, Pasquale, Capparuccia, Marco R., Romiti, Giulio F., Rossi, Elisabetta, Ruscio, Eleonora, Russo, Alessandro, Solimando, Luisa, Trapè, Stefano, Toriello, Filippo, Cangemi, Roberto, Calvieri, Camilla, Falcone, Marco, Bucci, Tommaso, Bertazzoni, Giuliano, Scarpellini, Maria G., Barillà, Francesco, Taliani, Gloria, and Violi, Francesco

Published
2015
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19. A simple rule to personalize standard dual therapy across all genotypes in naive chronic hepatitis C patients: The TT4 randomized trial

Author

Francioso, Simona, Almerighi, Cristiana, Forte, Paolo, Bandiera, Franco, Nosotti, Lorenzo, Lionetti, Raffaella, Taliani, Gloria, Piras, Maria Rosaria, Ponti, Maria Laura, Parruti, Giustino, Di Candilo, Francesco, Gentile, Silvia, Piccolo, Paola, Salso, Angela, Riccobelli, Francesca, Renzi, Sara, Longo, Maria Antonella, Montalbano, Marzia, Zaru, Salvatore, Biliotti, Elisa, Di Masi, Francesco, Santopaolo, Francesco, and Angelico, Mario

Published
2014
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20. Prevalence of Single and Multiple Natural NS3, NS5A and NS5B Resistance-Associated Substitutions in Hepatitis C Virus Genotypes 1–4 in Italy

Author

Bertoli, Ada, Sorbo, Maria Chiara, Aragri, Marianna, Lenci, Ilaria, Teti, Elisabetta, Polilli, Ennio, Di Maio, Velia Chiara, Gianserra, Laura, Biliotti, Elisa, Masetti, Chiara, Magni, Carlo F., Babudieri, Sergio, Nicolini, Laura A., Milana, Martina, Cacciatore, Pierluigi, Sarmati, Loredana, Pellicelli, Adriano, Paolucci, Stefania, Craxì, Antonio, Morisco, Filomena, Palitti, Valeria Pace, Siciliano, Massimo, Coppola, Nicola, Iapadre, Nerio, Puoti, Massimo, Rizzardini, Giuliano, Taliani, Gloria, Pasquazzi, Caterina, Andreoni, Massimo, Parruti, Giustino, Angelico, Mario, Perno, Carlo Federico, Cento, Valeria, Ceccherini-Silberstein, Francesca, and HCV Virology Italian Resistance Network (VIRONET-C)

Published
2018
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23. De-novo occurrence of portal vein thrombosis in patients with HCV-related cirrhosis after sustained virological response: medium to long term observations from the ongoing PITER cohort

Author

Kondili, Loreta, primary, Quaranta, Maria Giovanna, additional, Ferrigno, Luigina, additional, Coppola, Carmine, additional, Monti, Monica, additional, Filomia, Roberto, additional, Brancaccio, Giuseppina, additional, Brunetto, Maurizia, additional, Biliotti, Elisa, additional, Ieluzzi, Donatella, additional, Iannone, Andrea, additional, Madonia, Salvatore, additional, Tata, Xhimi, additional, Cavalletto, Luisa, additional, Cossiga, Valentina, additional, Amodeo, Simona, additional, Calvaruso, Vincenza, additional, Del Turco, Elena Rosselli, additional, Rumi, Maria Grazia, additional, Pompili, Maurizio, additional, Ciancio, Alessia, additional, Brescini, Lucia, additional, and Russo, Francesco Paolo, additional

Published
2022
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24. A prospective study of direct‐acting antiviral effectiveness and relapse risk in HCV cryoglobulinemic vasculitis by the Italian PITER cohort

Author

Kondili, Loreta A., primary, Monti, Monica, additional, Quaranta, Maria Giovanna, additional, Gragnani, Laura, additional, Panetta, Valentina, additional, Brancaccio, Giuseppina, additional, Mazzaro, Cesare, additional, Persico, Marcello, additional, Masarone, Mario, additional, Gentile, Ivan, additional, Andreone, Pietro, additional, Madonia, Salvatore, additional, Biliotti, Elisa, additional, Filomia, Roberto, additional, Puoti, Massimo, additional, Fracanzani, Anna Ludovica, additional, Laccabue, Diletta, additional, Ieluzzi, Donatella, additional, Coppola, Carmine, additional, Rumi, Maria Grazia, additional, Benedetti, Antonio, additional, Verucchi, Gabriella, additional, Coco, Barbara, additional, Chemello, Liliana, additional, Iannone, Andrea, additional, Ciancio, Alessia, additional, Russo, Francesco Paolo, additional, Barbaro, Francesco, additional, Morisco, Filomena, additional, Chessa, Luchino, additional, Massari, Marco, additional, Blanc, Pierluigi, additional, and Zignego, Anna Linda, additional

Published
2022
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25. SARS-CoV-2 Nasopharyngeal Viral Load in Individuals Infected with BA.2, Compared to Alpha, Gamma, Delta and BA.1 Variants: A Single-Center Comparative Analysis

Author

Mastrorosa, Ilaria, primary, Lepri, Alessandro Cozzi, additional, Colavita, Francesca, additional, Lalle, Eleonora, additional, Mazzotta, Valentina, additional, Cimaglia, Claudia, additional, Paulicelli, Jessica, additional, Matusali, Giulia, additional, Fabeni, Lavinia, additional, Carletti, Fabrizio, additional, Rosati, Silvia, additional, Vita, Serena, additional, Giannico, Giuseppina, additional, Piselli, Pierluca, additional, Biliotti, Elisa, additional, Al Moghazi, Samir, additional, Mosti, Silvia, additional, Girardi, Enrico, additional, Nicastri, Emanuele, additional, Garbuglia, Anna Rosa, additional, Maggi, Fabrizio, additional, Vaia, Francesco, additional, and Antinori, Andrea, additional

Published
2022
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27. Nox2 up-regulation is associated with an enhanced risk of atrial fibrillation in patients with pneumonia

Author

Violi, Francesco, Carnevale, Roberto, Calvieri, Camilla, Nocella, Cristina, Falcone, Marco, Farcomeni, Alessio, Taliani, Gloria, Cangemi, Roberto, Battaglia, Simona, Bertazzoni, Giuliano, Biliotti, Elisa, Bucci, Tommaso, Calabrese, Cinzia Myriam, Casciaro, Marco, Celestini, Andrea, De Marzio, Paolo, Fazi, Lucia, Giordo, Laura, Manzini, Elisa, Morelli, Sergio, Pastori, Daniele, Pignatelli, Pasquale, Romiti, Giulio Francesco, Rossi, Elisabetta, Ruscio, Eleonora, Scarpellini, Maria Gabriella, Solimando, Luisa, Toriello, Filippo, De Angelis, Maurizio, Esvan, Rozenn, Sulekova, Lucia Fontanelli, Franchi, Cristiana, Grieco, Stefania, Capparuccia, Marco Rivano, Marinelli, Paolo, Mordenti, Michela, Palange, Paolo, and Russo, Alessandro

Published
2015
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28. Impact of HCV Eradication on Lipid Metabolism in HIV/HCV Coinfected Patients: Data from ICONA and HepaICONA Foundation Cohort Study

Author

Spaziante, Martina, Taliani, Gloria, Marchetti, Giulia, Tavelli, Alessandro, Lichtner, Miriam, Cingolani, Antonella, Cicalini, Stefania, Biliotti, Elisa, Girardi, Enrico, Antinori, Andrea, Puoti, Massimo, d’Arminio Monforte, Antonella, Cozzi-Lepri, Alessandro, Pellicanò, Giovanni Francesco, Spaziante, M, Taliani, G, Marchetti, G, Tavelli, A, Lichtner, M, Cingolani, A, Cicalini, S, Biliotti, E, Girardi, E, Antinori, A, Puoti, M, Monforte, A, and Cozzi-Lepri, A

Subjects
Male, 0301 basic medicine, antiretroviral treatment, Sustained Virologic Response, HIV Infections, Hepacivirus, Disease, Gastroenterology, Cohort Studies, chemistry.chemical_compound, 0302 clinical medicine, HCV eradication, Genotype, lipid metabolism, virus diseases, Middle Aged, HIV/HCV coinfected patients, HCV genotype, darunavir/ritonavir, Hepatitis C, QR1-502, Cholesterol, Infectious Diseases, Italy, HIV/HCV coinfected patient, Female, 030211 gastroenterology & hepatology, medicine.drug, Cohort study, medicine.medical_specialty, Settore MED/17 - Malattie Infettive, Bilirubin, Antiviral Agents, Cholesterol, LDL, Disease Eradication, Humans, Lipid Metabolism, Microbiology, Article, LDL, 03 medical and health sciences, Virology, Internal medicine, medicine, Darunavir, business.industry, Lipid metabolism, digestive system diseases, MED/17 - MALATTIE INFETTIVE, 030104 developmental biology, chemistry, Ritonavir, Liver function, business
Abstract

Objectives: HCV shows complex interactions with lipid metabolism. Our aim was to examine total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) changes in HIV/HCV coinfected patients, after achieving sustained virological response (SVR), according to different HCV genotypes and specific antiretroviral use. Methods: HIV/HCV coinfected patients, enrolled in the ICONA and HepaICONA cohorts, who achieved DAA-driven SVR were included. Paired t-tests were used to examine whether the pre- and post-SVR laboratory value variations were significantly different from zero. ANCOVA regression models were employed to estimate the causal effect of SVR and of PI/r use on lipid changes. The interaction between the effect of eradication and HCV genotype was formally tested. Results: six hundred and ninety-nine HIV/HCV coinfected patients were enrolled. After HCV eradication, a significant improvement in liver function occurred, with a significant decrease in AST, ALT, GGT, and total plasmatic bilirubin. TC and LDL-C significantly increased by 21.4 mg/dL and 22.4 mg/dL, respectively (p &lt, 0.001), after SVR, whereas there was no evidence for a change in HDL-C (p = 0.45) and triglycerides (p = 0.49). Notably, the TC and LDL-C increase was higher for participants who were receiving darunavir/ritonavir, and the TC showed a more pronounced increase among HCV genotype 3 patients (interaction-p value = 0.002). Conclusions: complex and rapid changes in TC and LDL-C levels, modulated by HCV genotype and PI/r-based ART combinations, occurred in HIV/HCV coinfected patients after SVR. Further studies are needed to evaluate the clinical impact of these changes on the long-term risk of cardiovascular disease.

Published
2021
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29. Short- and Long-Term Immunological Responses in Chronic HCV/HIV Co-Infected Compared to HCV Mono-Infected Patients after DAA Therapy

Author

Farcomeni, Stefania, primary, Moretti, Sonia, additional, Fimiani, Caterina, additional, Sulekova, Lucia Fontanelli, additional, Vescio, Fenicia, additional, Sernicola, Leonardo, additional, Maggiorella, Maria T., additional, Remoli, Anna Lisa, additional, Picconi, Orietta, additional, Mosca, Luciana, additional, Esvan, Rozenn, additional, Biliotti, Elisa, additional, Ciccozzi, Massimo, additional, Sgarbanti, Marco, additional, Taliani, Gloria, additional, and Borsetti, Alessandra, additional

Published
2021
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30. A prospective study of DAA Effectiveness and Relapse Risk in HCV Cryoglobulinemic Vasculitis by the Italian PITER Cohort

Author

Kondili, Loreta A, Monti, Monica, Quaranta, Maria Giovanna, Gragnani, Laura, Panetta, Valentina, Brancaccio, Giuseppina, Mazzaro, Cesare, Persico, Marcello, Masarone, Mario, Gentile, Ivan, Andreone, Pietro, Madonia, Salvatore, Biliotti, Elisa, Filomia, Roberto, Puoti, Massimo, Fracanzani, Anna Ludovica, Laccabue, Diletta, Ieluzzi, Donatella, Coppola, Carmine, Rumi, Maria Grazia, Benedetti, Antonio, Verucchi, Gabriella, Coco, Barbara, Chemello, Liliana, Iannone, Andrea, Ciancio, Alessia, Russo, Francesco Paolo, Barbaro, Francesco, Morisco, Filomena, Chessa, Luchino, Massari, Marco, Blanc, Pierluigi, and Zignego, Anna Linda

Subjects
Direct Acting Antivirals, Mixed Cryoglobulinemia, Clinical Response, Cryoglobulinemic Vasculitis, HCV-chronic infection
Published
2021

31. Glecaprevir/pibrentasvir ultra-short treatment to cure HCV infection: case report and literature review

Author

Volpicelli, Lorenzo, Biliotti, Elisa, Milito, Cinzia, Cruciata, Alessia, Spaziante, Martina, Rivano Capparuccia, Marco, Taliani, Gloria, and Mezzaroma, Ivano

Subjects
Cyclopropanes, Sulfonamides, Aminoisobutyric Acids, Pyrrolidines, HCV, DAA, ultra-short treatment, Proline, Lactams, Macrocyclic, Hepatitis C, Chronic, Antiviral Agents, Drug Combinations, Anti-Retroviral Agents, Leucine, Quinoxalines, Humans, Benzimidazoles, Female
Abstract

Shortening therapy duration with direct-acting antiviral agents (DAAs) is desirable to pursue the WHO target of HCV eradication by 2030. We report two cases of HCV-infected women who achieved sustained virologic response after an ultra-short treatment with glecaprevir/pibrentasvir (G/P), discontinued due to cutaneous adverse events, and analyze similar cases reported in the literature. Female gender seems to be a prevailing characteristic in this group of patients. G/P, due to its pangenotypic and strong antiviral activity, may represent a candidate for a shortened DAA regimen in non-cirrhotic treatment-naive subjects.

Published
2020

32. Clinical features and comorbidity pattern of HCV infected migrants compared to native patients in care in Italy: A real-life evaluation of the PITER cohort

Author

Quaranta, Maria Giovanna, primary, Ferrigno, Luigina, additional, Tata, Xhimi, additional, D'Angelo, Franca, additional, Massari, Marco, additional, Coppola, Carmine, additional, Biliotti, Elisa, additional, Giorgini, Alessia, additional, Laccabue, Diletta, additional, Ciancio, Alessia, additional, Blanc, Pier Luigi, additional, Margotti, Marzia, additional, Ieluzzi, Donatella, additional, Brunetto, Maurizia Rossana, additional, Barbaro, Francesco, additional, Russo, Francesco Paolo, additional, Beretta, Ilaria, additional, Morsica, Giulia, additional, Verucchi, Gabriella, additional, Saracino, Annalisa, additional, Galli, Massimo, additional, and Kondili, Loeta A., additional

Published
2021
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35. WED-146 - Epidemiological and clinical profile of HDV infected people in care in Italy: interim analysis from the ongoing PITER cohort

Author

Kondili, Loreta, Tosti, Maria Elena, Quaranta, Maria Giovanna, Ciancio, Alessia, Messina, Vincenzo, Brancaccio, Giuseppina, Brunetto, Maurizia, Capasso, Mario, Rosato, Valerio, Cacciola, Irene, Pasulo, Luisa, Santantonio, Teresa, Coppola, Carmine, Biliotti, Elisa, Barbaro, Francesco, Massari, Marco, Coppola, Nicola, Ferrarese, Alberto, Russo, Francesco Paolo, Di Marco, Vito, Marrone, Aldo, Schivazappa, Simona, Federico, Alessandro, Blanc, Pierluigi, Rocco, Alba, Morsica, Giulia, Ieluzzi, Donatella, Conti, Fabio, De Siena, Martina, Bavetta, Maria Grazia, Milella, Michele, Gentile, Ivan, Porcu, Carmen, Chemello, Liliana, Maracci, Monia, Zignego, Anna Linda, Baiocchi, Leonardo, Maida, Ivana Rita, and Coco, Barbara

Published
2023
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36. HCV cirrhotic patients treated with direct‐acting antivirals: Detection of tubular dysfunction and resolution after viral clearance

Author

Biliotti, Elisa, primary, Palazzo, Donatella, additional, Tinti, Francesca, additional, D'Alessandro, Maria Domenica, additional, Esvan, Rozenn, additional, Labriola, Raffaella, additional, Cappoli, Andrea, additional, Umbro, Ilaria, additional, Volpicelli, Lorenzo, additional, Bachetoni, Alessandra, additional, Villa, Erica, additional, Mitterhofer, Anna Paola, additional, Rucci, Paola, additional, and Taliani, Gloria, additional

Published
2020
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38. The weight of pre-existing cofactors for liver disease progression in patients who successfully eradicated chronic hepatitis C viral infection: an interim analysis in the PITER cohort

Author

Kondili, Loreta, primary, Quaranta, Maria Giovanna, additional, Monti, Monica, additional, Amoruso, Daniela Caterina, additional, Filomia, Roberto, additional, Biliotti, Elisa, additional, Iannone, Andrea, additional, Ieluzzi, Donatella, additional, Coco, Barbara, additional, Russo, Francesco Paolo, additional, Beretta, Ilaria, additional, Parruti, Giustino, additional, Blanc, Pierluigi, additional, Vinci, Maria, additional, Cossiga, Valentina, additional, Degasperi, Elisabetta, additional, Chemello, Liliana, additional, Massari, Marco, additional, Badia, Lorenzo, additional, Puoti, Massimo, additional, Bruno, Serena, additional, De Siena, Martina, additional, Panetta, Valentina, additional, and Aghemo, Alessio, additional

Published
2020
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40. FRI347 - De-novo occurrence of portal vein thrombosis in patients with HCV-related cirrhosis after sustained virological response: medium to long term observations from the ongoing PITER cohort

Author

Kondili, Loreta, Quaranta, Maria Giovanna, Ferrigno, Luigina, Coppola, Carmine, Monti, Monica, Filomia, Roberto, Brancaccio, Giuseppina, Brunetto, Maurizia, Biliotti, Elisa, Ieluzzi, Donatella, Iannone, Andrea, Madonia, Salvatore, Tata, Xhimi, Cavalletto, Luisa, Cossiga, Valentina, Amodeo, Simona, Calvaruso, Vincenza, Del Turco, Elena Rosselli, Rumi, Maria Grazia, Pompili, Maurizio, Ciancio, Alessia, Brescini, Lucia, and Russo, Francesco Paolo

Published
2022
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41. Vitamin D deficiency and health-related quality of life in chronic hepatitis C

Author

Palazzo, Donatella, Biliotti, Elisa, Esvan, Rozenn, Volpicelli, Lorenzo, Franchi, Cristiana, Fontanelli Sulekova, Lucia, Spaziante, Martina, Santori, Marta, Rugova, Alban, Rucci, Paola, Taliani, Gloria, Palazzo D., Biliotti E., Esvan R., Volpicelli L., Franchi C., Fontanelli Sulekova L., Spaziante M., Santori M., Rugova A., Rucci P., and Taliani G.

Subjects
Male, medicine.medical_specialty, vitamin D, Gastroenterology, vitamin D deficiency, Chronic hepatitis, Risk Factors, health survey short form-36, Internal medicine, Virology, Prevalence, medicine, Vitamin D and neurology, Humans, chronic hepatitis C, Aged, Health related quality of life, Hepatology, business.industry, Hepatitis C, Chronic, Middle Aged, Vitamin D Deficiency, medicine.disease, health-related quality of life, Cross-Sectional Studies, Infectious Diseases, Quality of Life, Female, business
Abstract

non presente perché short communication

Published
2019

42. Molecular characterization of Blastocystis subtypes in HIV-positive patients and evaluation of risk factors for colonization

Author

Sulekova, Lucia Fontanelli, primary, Gabrielli, Simona, additional, Furzi, Federica, additional, Milardi, Giovanni Luigi, additional, Biliotti, Elisa, additional, De Angelis, Maurizio, additional, Iaiani, Giancarlo, additional, Fimiani, Caterina, additional, Maiorano, Myriam, additional, Mattiucci, Simonetta, additional, and Taliani, Gloria, additional

Published
2019
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46. Real-Life use of Elbasvir/Grazoprevir in Adults and Elderly Patients: A Prospective Evaluation of Comedications used in the PITER Cohort

Author

Quaranta, Maria Giovanna, primary, Rosato, Stefano, additional, Ferrigno, Luigina, additional, Amoruso, Daniela Caterina, additional, Monti, Monica, additional, Di Stefano, Paola, additional, Filomia, Roberto, additional, Biliotti, Elisa, additional, Migliorino, Guglielmo, additional, Russo, Francesco Paolo, additional, Degasperi, Elisabetta, additional, Chemello, Liliana, additional, Brancaccio, Giuseppina, additional, Blanc, Pierluigi, additional, Cannizzaro, Marco, additional, Barbaro, Francesco, additional, Morsica, Giulia, additional, Licata, Anna, additional, and Kondili, Loreta A, additional

Published
2019
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47. Corticosteroid Use and Incident Myocardial Infarction in Adults Hospitalized for Community-acquired Pneumonia

Author

Cangemi, Roberto, primary, Falcone, Marco, additional, Taliani, Gloria, additional, Calvieri, Camilla, additional, Tiseo, Giusy, additional, Romiti, Giulio Francesco, additional, Bertazzoni, Giuliano, additional, Farcomeni, Alessio, additional, Violi, Francesco, additional, Battaglia, Simona, additional, Biliotti, Elisa, additional, Calabrese, Cinzia Myriam, additional, Celestini, Andrea, additional, Casciaro, Marco, additional, De Angelis, Maurizio, additional, Di Diego, Ilaria, additional, De Marzio, Paolo, additional, Esvan, Rozenn, additional, Ferraro, Giovanni, additional, Sulekova, Lucia Fontanelli, additional, Franchi, Cristiana, additional, Giordo, Laura, additional, Khoury, Fuad, additional, Morelli, Sergio, additional, Catassi, Giulia Naspi, additional, Palange, Paolo, additional, Pastori, Daniele, additional, Prosperi, Anna, additional, Raparelli, Valeria, additional, Capparuccia, Marco Rivano, additional, Rossi, Elisabetta, additional, Scarpellini, Maria Gabriella, additional, Trapè, Stefano, additional, Toriello, Filippo, additional, Vano, Marco, additional, and Venditti, Mario, additional

Published
2019
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49. HCV cirrhotic patients treated with direct‐acting antivirals: Detection of tubular dysfunction and resolution after viral clearance.

Author

Biliotti, Elisa, Palazzo, Donatella, Tinti, Francesca, D'Alessandro, Maria Domenica, Esvan, Rozenn, Labriola, Raffaella, Cappoli, Andrea, Umbro, Ilaria, Volpicelli, Lorenzo, Bachetoni, Alessandra, Villa, Erica, Mitterhofer, Anna Paola, Rucci, Paola, and Taliani, Gloria

Subjects
*ANTIVIRAL agents, *HEPATITIS C virus, *CHRONIC kidney failure, *RENAL tubular transport disorders, *PATIENTS' attitudes, *CHRONIC hepatitis C, PORTAL vein diseases
Abstract

Background/Aims: Hepatitis C virus (HCV) has been identified in tubular epithelial cells of infected patients; however, the presence of tubular dysfunction, which is a risk factor for chronic kidney disease (CKD), has never been examined in vivo. The present prospective longitudinal study aimed to estimate the prevalence of tubular dysfunction alone or with glomerular damage and its evolution after HCV clearance in cirrhotic patients. Methods: One hundred and thirty‐five consecutive Child‐Pugh A cirrhotic patients were evaluated before antiviral treatment and 6 months after the end of therapy. Tubular dysfunction was evaluated by urinary alpha1‐microglobulin to creatinine ratio (α1‐MCR), and glomerular damage was assessed by urinary albumin to creatinine ratio (ACR). Results: Almost all the patients (93.3%) showed a normal or mildly decreased e‐GFR (KDIGO‐G1/G2‐categories). Tubular dysfunction was found in 23.7% (32/135) of patients, co‐occurring with glomerular damage in 37.5% (12/32) of cases, while glomerular damage was found in 16.3% (22/135) of patients. In multiple logistic regression, glomerular damage and the concomitant presence of diabetes and hypertension were the only predictors significantly associated with tubular dysfunction. After HCV clearance, patients experienced a significant reduction of α1‐MCR levels (21.0 vs 10.5 μg/mg, P =.009) and tubular dysfunction resolved in 57.1% of subjects. Conclusions: Tubular dysfunction is an unrecognized feature of HCV‐related kidney disease in cirrhotic patients and its presence should be primarily investigated in subjects with glomerular damage, diabetes and hypertension, despite normal e‐GFR. Tubular dysfunction resolves in the majority of cases after HCV clearance; however, it may persist after antiviral treatment and further studies should evaluate its long‐term impact on kidney function. [ABSTRACT FROM AUTHOR]

Published
2021
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50. Advanced liver disease outcomes after hepatitis C eradication by human immunodeficiency virus infection in PITER cohort.

Author

Quaranta, Maria Giovanna, Ferrigno, Luigina, Monti, Monica, Filomia, Roberto, Biliotti, Elisa, Iannone, Andrea, Migliorino, Guglielmo, Coco, Barbara, Morisco, Filomena, Vinci, Maria, D'Ambrosio, Roberta, Chemello, Liliana, Massari, Marco, Ieluzzi, Donatella, Russo, Francesco Paolo, Blanc, Pierluigi, Verucchi, Gabriella, Puoti, Massimo, Rumi, Maria Grazia, and Barbaro, Francesco

Abstract

Background: Liver disease progression after Hepatitis C Virus (HCV) eradication following direct-acting antiviral (DAA) treatment in the real-life setting according to Human Immunodeficiency Virus (HIV) coinfection was evaluated. Methods: Patients consecutively enrolled in PITER between April 2014 and June 2019 and with at least 12-weeks follow-up following treatment were analysed. Cox regression analysis were used to evaluate HIV coinfection and factors independently associated with liver disease outcomes following viral eradication in DAA treated patients with pre-treatment liver cirrhosis. Results: 93 HIV/HCV coinfected and 1109 HCV monoinfected patients were evaluated during a median follow-up of 26.7 (range 6–44.6) and 24.6 (range 6.8–47.3) months, respectively. No difference in the cumulative HCC incidence and hepatic decompensation was observed between coinfected and monoinfected patients. Age (Hazard Ratio [HR] = 1.08; 95% CI 1.04–1.13), male sex (HR = 2.76; 95% CI 1.28–5.96), lower albumin levels (HR = 3.94; 95% CI 1.81–8.58), genotype 3 (HR = 5.05; 95% CI 1.75–14.57) and serum anti-HBc positivity (HR = 1.99, 95% CI 1.01–3.95) were independently associated with HCC incidence. Older age (HR = 1.03; 95% CI 1.00–1.07), male sex (HR = 2.13; 95% CI 1.06–4.26) and lower albumin levels (HR = 3.75; 95% CI 1.89–7.46) were independently associated with the appearance of a decompensating event after viral eradication. Conclusion: Different demographic, clinical and genotype distribution between HIV coinfected vs those monoinfected, was observed in a representative cohort of HCV infected patients in Italy. Once liver cirrhosis is established the disease progression is decreased, but still persists regardless of viral eradication in both coinfected and monoinfected patients. In patients with cirrhosis, HIV coinfection was not associated with a higher probability of liver complications, after viral eradication. [ABSTRACT FROM AUTHOR]

Published
2020
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