109 results on '"Bilge I"'
Search Results
2. The overlooked association between lower urinary tract dysfunction and psychiatric disorders: a short screening test for clinical practice
- Author
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Özen, M.A., Mutluer, T., Necef, I., Shabsog, M., Taşdemir, M., Bilge, I., and Eroğlu, E.
- Published
- 2019
- Full Text
- View/download PDF
3. Global Variation of Nutritional Status in Children Undergoing Chronic Peritoneal Dialysis: A Longitudinal Study of the International Pediatric Peritoneal Dialysis Network
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Schaefer, Franz, Benner, Laura, Borzych-Duzalka, Dagmara, Zaritsky, Joshua, Xu, Hong, Rees, Lesley, Antonio, Zenaida L., Serdaroglu, Erkin, Hooman, Nakysa, Patel, Hiren, Sever, Lale, Vondrak, Karel, Flynn, Joseph, Rebori, Anabella, Wong, William, Holtta, Tuula, Yildirim, Zeynep Yuruk, Ranchin, Bruno, Grenda, Ryszard, Testa, Sara, Drozdz, Dorota, Szabo, Attila J., Eid, Loai, Basu, Biswanath, Vitkevic, Renate, Wong, Cynthia, Pottoore, Stephen J., Mueller, Dominik, Dusunsel, Ruhan, Celedon, Claudia Gonzalez, Fila, Marc, Sartz, Lisa, Sander, Anja, Warady, Bradley A., Adragna, M., Coccia, P. A., Suarez, A., Valles, P. G., Salim, R., Alconcher, L., Arbeiter, K., van Hoeck, K., Koch, V, Feber, J., Harvey, E., White, C., Valenzuela, M., Villagra, J., Cano, F., Contreras, M. A., Vogel, A., Zambrano, P., Hevia, P., Chiu, M. C., Ding, Jie, Vanegas, J. J., Higuita, L. M., Roussey, G., Ulinski, T., Krid, S., Fischbach, M., Harambat, J., Samaille, Ch, Buescher, R., Oh, J., Pape, L., John, U., Klaus, G., Billing, H., Stafanidis, C., Papachristou, F., Bagga, A., Kanitkar, M., Sinha, R., Sethi, S., Verrinam, E., Vidal, E., Leozappa, G., Landau, D., Paik, K. H., Bilal, A., Sahpazova, E., Lim, Y. N., Barbosa, L. Sanchez, Groothoff, J. W., Konijenberg, Y., Silva, Y., Al Ryami, M., Munarriz, R. Loza, Leszepanska, B., Szczepanska, M., Brumariu, O., Kari, J., Kruscic, D., Yap, H. K., Ariceta, G., Aguirre, M., Santos, F., Niwhiska-Faryna, B., Bayazit, A., Bakkaloglu, C. A. S., Bakkaloglu, S., Bilge, I, Yavascan, O., Mir, S., Simkova, Eva, Christian, M., Greenbaum, L., Neu, A., Askenazi, D., Al-Akash, A., Swartz, S., Brophy, P., Rheault, M., Pradhan, M., Pediatric surgery, Amsterdam Reproduction & Development (AR&D), Çukurova Üniversitesi, Büscher (R.), Rainer (Beitragende*r), Paediatric Nephrology, AGEM - Inborn errors of metabolism, APH - Methodology, APH - Quality of Care, ARD - Amsterdam Reproduction and Development, Ege Üniversitesi, Int Pediat Peritoneal Dial Network, Children's Hospital, Clinicum, and HUS Children and Adolescents
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Male ,0301 basic medicine ,Pediatric Obesity ,Longitudinal study ,Pediatrics ,medicine.medical_treatment ,Medizin ,lcsh:Medicine ,Overweight ,DISEASE ,0302 clinical medicine ,Risk Factors ,Prevalence ,Longitudinal Studies ,Registries ,Child ,lcsh:Science ,RISK ,2. Zero hunger ,OUTCOMES ,Multidisciplinary ,3. Good health ,Europe ,OBESITY ,Child, Preschool ,GROWTH ,Female ,medicine.symptom ,Underweight ,Peritoneal Dialysis ,Engineering sciences. Technology ,medicine.medical_specialty ,Asia ,Adolescent ,Nutritional Status ,Article ,Peritoneal dialysis ,03 medical and health sciences ,Enteral Nutrition ,Thinness ,medicine ,Humans ,Dialysis ,business.industry ,MORTALITY ,lcsh:R ,Infant ,nutritional and metabolic diseases ,medicine.disease ,Obesity ,BODY-MASS INDEX ,030104 developmental biology ,3121 General medicine, internal medicine and other clinical medicine ,Kidney Failure, Chronic ,lcsh:Q ,Americas ,business ,Body mass index ,030217 neurology & neurosurgery ,Kidney disease - Abstract
WOS: 000461762600003, PubMed ID: 30894599, While children approaching end-stage kidney disease (ESKD) are considered at risk of uremic anorexia and underweight they are also exposed to the global obesity epidemic. We sought to investigate the variation of nutritional status in children undergoing chronic peritoneal dialysis (CPD) around the globe. The distribution and course of body mass index (BMI) standard deviation score over time was examined prospectively in 1001 children and adolescents from 35 countries starting CPD who were followed in the International Pediatric PD Network (IPPN) Registry. The overall prevalence of underweight, and overweight/obesity at start of CPD was 8.9% and 19.7%, respectively. Underweight was most prevalent in South and Southeast Asia (20%), Central Europe (16.7%) and Turkey (15.2%), whereas overweight and obesity were most common in the Middle East (40%) and the US (33%). BMI SDS at PD initiation was associated positively with current eGFR and gastrostomy feeding prior to PD start. Over the course of PD BMI SDS tended to increase on CPD in underweight and normal weight children, whereas it decreased in initially overweight patients. In infancy, mortality risk was amplified by obesity, whereas in older children mortality was markedly increased in association with underweight. Both underweight and overweight are prevalent in pediatric ESKD, with the prevalence varying across the globe. Late dialysis start is associated with underweight, while enteral feeding can lead to obesity. Nutritional abnormalities tend to attenuate with time on dialysis. Mortality risk appears increased with obesity in infants and with underweight in older children., International Society for Peritoneal Dialysis; Baxter Health Care; Fresenius Medical Care, The authors gratefully acknowledge the support by the International Society for Peritoneal Dialysis, Baxter Health Care, and Fresenius Medical Care. We also appreciate the continued dedicated support of the IPPN by the medical and nursing staff in all collaborating centers.
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- 2019
4. Frequency of renal malformations in Turner syndrome: analysis of 82 Turkish children
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Bilge, I., Kayserili, H., Emre, S., Nayir, A., Sirin, A., Tukel, T., Bas, F., Kilic, G., Basaran, S., Gunoz, H., and Apak, M.
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- 2000
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5. Hemostatic problems and thromboembolic complications in nephrotic children
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Citak, A., Emre, S., Sâirin, A., Bilge, I., and Nayır, A.
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- 2000
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6. Dynamics in between Structural and Electrical Properties of as Grown ZnO Thin Films by Thermal ALD
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Bilge İMER
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zinc oxide ,oxide semiconductors ,atomic layer deposition ,tco ,ald ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Science ,Science (General) ,Q1-390 - Abstract
The mechanism behind n-type conductivity of undoped ZnO films are not understood well. One and two dimensional defects (grain boundaries, dislocations), and zero dimensional stoichiometric point defects (vacancies, self-interstitials and impurities) play a crucial role in determining the electrical properties of ZnO. All defect mechanisms are strongly controlled by the growth method and conditions. While it is more straightforward examining the one and two dimensional defects, measuring and unveiling the mechanism behind the zero dimensional point defect contribution and their sole effect on the electrical properties are challenging. This is why there has been controversial discussion of results among experimental and computational works relating physical and chemical properties of ZnO to sustainable electrical properties. In this study, to correlate the dynamics in between structural and electrical properties of ZnO grown by thermal ALD; growth temperature, DEZ and DI water precursor pulse times, DEZ/DI water precursor pulse ratio, and N2 purge time were varied. To obtain growth condition specific structural and electrical properties; XRD, AFM, profilometer, ellipsometry, XPS/CasaXPS, UV-VIS spectrometer, Hall-Effect measurements were utilized. Although, there was no strong correlation for oxygen vacancies, the contribution of hydrogen impurities, zinc interstitials and oxygen vacancies to conductivity was observed at different growth conditions. Lowest resistivity and highest average % transmittance were obtained as 6.8x10-3 ohm.cm and 92% in visible spectrum (380-700 nm), respectively.
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- 2023
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7. The Generalized Fractional-Order Fisher Equation: Stability and Numerical Simulation
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Bilge İnan
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generalized fractional-order Fisher equation ,time-fractional equations ,exponential finite difference method ,conformable fractional derivative ,Mathematics ,QA1-939 - Abstract
This study examines the stability and numerical simulation of the generalized fractional-order Fisher equation. The equation serves as a mathematical model describing population dynamics under the influence of factors such as natural selection and migration. We propose an implicit exponential finite difference method to solve this equation, considering the conformable fractional derivative. Furthermore, we analyze the stability of the method through theoretical considerations. The method involves transforming the problem into systems of nonlinear equations at each time since our method is an implicit method, which is then solved by converting them into linear equations systems using the Newton method. To test the accuracy of the method, we compare the results obtained with exact solutions and with those available in the literature. Additionally, we examine the symmetry of the graphs obtained from the solution to examine the results. The findings of our numerical simulations demonstrate the effectiveness and reliability of the proposed approach in solving the generalized fractional-order Fisher equation.
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- 2024
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8. The analysis of TMS brain mapping of plastic changes in scapular-arm replantation patients
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Gok, K., primary, Doger, E.N., additional, Goztepe, M.B., additional, Uysal, H., additional, Ozkan, O., additional, Senol, U., additional, Apaydin Dogan, E., additional, Barcin, E., additional, Bilge, I., additional, Savkliyildiz, A., additional, Carlak, H.F., additional, Polat, O., additional, and Colak, O.H., additional
- Published
- 2017
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9. Editorial: Modeling and numerical simulations with differential equations in mathematical biology, medicine, and the environment
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Appanah R. Appadu, Ramoshweu S. Lebelo, Hagos H. Gidey, and Bilge Inan
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modeling ,differential equations ,mathematical biology ,medicine ,environment ,simulation ,Applied mathematics. Quantitative methods ,T57-57.97 ,Probabilities. Mathematical statistics ,QA273-280 - Published
- 2023
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10. Urinary Stone Disease in Turkish Children
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Sirin, A., AL, SERDAR, Emre, S., Sucu, A., and Bilge, I.
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- 2010
11. Convergence Analysis and Approximate Optimal Temporal Step Sizes for Some Finite Difference Methods Discretising Fisher's Equation
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Koffi Messan Agbavon, Appanah Rao Appadu, Bilge Inan, and Herve Michel Tenkam
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Fisher's equation ,FTCS ,NSFD ,EEFD ,optimal ,convergence estimate ,Applied mathematics. Quantitative methods ,T57-57.97 ,Probabilities. Mathematical statistics ,QA273-280 - Abstract
In this study, we obtain a numerical solution for Fisher's equation using a numerical experiment with three different cases. The three cases correspond to different coefficients for the reaction term. We use three numerical methods namely; Forward-Time Central Space (FTCS) scheme, a Nonstandard Finite Difference (NSFD) scheme, and the Explicit Exponential Finite Difference (EEFD) scheme. We first study the properties of the schemes such as positivity, boundedness, and stability and obtain convergence estimates. We then obtain values of L1 and L∞ errors in order to obtain an estimate of the optimal time step size at a given value of spatial step size. We determine if the optimal time step size is influenced by the choice of the numerical methods or the coefficient of reaction term used. Finally, we compute the rate of convergence in time using L1 and L∞ errors for all three methods for the three cases.
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- 2022
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12. The EULAR/PRINTO/PRES criteria for Henoch-Schönlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis, and childhood Takayasu arteritis: ankara 2008. part ii: final classification criteria
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Ozen, S, Pistorio, A, Iusan, Sm, Bakkaloglu, A, Herlin, T, Brik, R, Buoncompagni, A, Lazar, C, Bilge, I, Uziel, Y, Rigante, D, Cantarini, L, Hilario, Mo, Silva, Ca, Alegria, M, Norambuena, X, Belot, A, Berkun, Y, Amparo Ibanez, E, Olivieri, An, Alpigiani, Mg, Rumba, I, Sztajnbok, F, Tambic Bukovac, L, Breda, L, Al Mayouf, S, Mihaylova, D, Chasnyk, V, Sengler, C, Klein Gitelman, M, Djeddi, D, Nuno, L, Pruunsild, C, Brunner, J, Kondi, A, Pagava, K, Pederzoli, S, Martini, Alberto, and Ruperto, N.
- Published
- 2010
13. Relapsing peritonitis in children who undergo chronic peritoneal dialysis: A prospective study of the International Pediatric Peritonitis Registry
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Lane, J.C. Warady, B.A. Feneberg, R. Majkowski, N.L. Watson, A.R. Fischbach, M. Kang, H.G. Bonzel, K.E. Simkova, E. Stefanidis, C.J. Klaus, G. Alexander, S.R. Ekim, M. Bilge, I. Schaefer, F.
- Abstract
Background and objectives: The International Pediatric Peritonitis Registry (IPPR) was established to collect prospective data regarding peritoneal dialysis (PD)-associated peritonitis in children. In this report, we present the IPPR results that pertain to relapsing peritonitis (RP). Design, setting, participants, & measurements: This was an online, prospective entry into the IPPR of data that pertain to peritonitis cases by participating centers. Results: Of 490 episodes of nonfungal peritonitis, 52 (11%) were followed by a relapse. There was no significant difference between RP and non-RP in distribution of causative organisms and antibiotic sensitivities. Initial empiric therapy - ceftazidime with either first-generation cephalosporin or glycopeptide (vancomycin or teicoplanin) - was not associated with relapse. Switching to monotherapy with a first-generation cephalosporin on the basis of culture results was associated with higher relapse rate (23%) than other final antibiotic therapies (0 to 9%). Culture-negative RP was less likely to have a satisfactory early treatment response than non-RP (82 versus 98%). Young age, single-cuff catheter, downward-pointing exit site, and chronic systemic antibiotic prophylaxis were additional independent risk factors for RP in the multivariate analysis. Compared with non-RP, RP was associated with a lower rate of full functional recovery (73 versus 91%), higher ultrafiltration problems (14 versus 2%), and higher rate of permanent PD discontinuation (17 versus 7%). Conclusions: This is the largest multicenter, prospective study to date to examine RP in children. In addition, this is the first report in the literature to examine specifically the relationship of postempiric antibiotic treatment regimens to the subsequent risk for relapse. Copyright © 2010 by the American Society of Nephrology.
- Published
- 2010
14. P.1.i.039 - The analysis of TMS brain mapping of plastic changes in scapular-arm replantation patients
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Gok, K., Doger, E.N., Goztepe, M.B., Uysal, H., Ozkan, O., Senol, U., Apaydin Dogan, E., Barcin, E., Bilge, I., Savkliyildiz, A., Carlak, H.F., Polat, O., and Colak, O.H.
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- 2017
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15. Preventable etiologies of chronic renal insuficiency in Turkey and effect to morbidity
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Bek, K., Sema AKMAN, Bilge, I., Topaloglu, R., Soylemezoglu, O., Caliskan, S., Peru, H., and Cengiz, N.
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- 2007
16. Familial Mediterranean Fever (FMF) in Turkey: Results of a nationwide multicenter study
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Derici, ÜLVER, Arici, M, Atagunduz, P, Erdogan, O, Cobankara, V, Akoglu, E, Cefle, A, Direskeneli, H, Oner, A, Ozmen, M, Keser, G, Tunc, E, Temel, M, Tuglular, S, Buyan, N, Goker, B, Kabasakal, Y, Kalman, S, Ozkaya, O, Yilmaz, E, Bakkaloglu, A, Oktem, F, Islek, I, Dusunsel, R, Pay, S, Gunduz, Z, Besbas, N, Akpolat, T, Dinc, A, Erken, E, Tirpan, K, Ozer, HTE, Birlik, M, Soyturk, M, Senturk, T, Demircin, G, Delibas, A, Bulbul, M, Bek, K, Poyrazoglu, MH, Sucu, A, Sirin, A, Bayraktar, Y, Apras, S, Calguneri, M, Duzova, A, Topaloglu, R, Ozen, S, Kav, T, Ozaltin, F, Simsek, H, Sivri, B, Tutar, E, Yalcinkaya, F, KASAPÇOPUR, Özgür, Ozdogan, H, Onen, F, Tatar, G, Akkoc, N, Kavukcu, S, Soylu, A, Akar, S, Ozguc, M, Dundar, M, Akar, E, Akar, N, Ozel, D, Yakupoglu, G, Tunca, M, Yucel, E, Gonen, SEVİM, Misirlioglu, M, Turkmen, M, Unsal, E, Arisoy, N, Emre, S, Gok, F, Caliskan, S, Gogus, F, Masatlioglu, S, Soylemezoglu, O, Sever, L, Saatci, U, Baskin, E, Korkmaz, C, Erdem, H, Akkok, N, Demirkaya, E, Gunesacar, R, Cakar, N, Altiok, O, Kara, N, Booth, DR, Kocak, H, Hawkins, PN, Touitou, I, Tekin, M, Aksentijevich, I, Matzner, Y, Arslan, S, Balaban, Y, Batman, F, Ozalp, S, Selcukbiricik, F, Sadikoglu, B, Kamali, S, Ekim, M, Ozkaya, N, Gul, A, Bilge, I, Koseoglu, HK, Coban, E, Balci, B, Bakkaloglu, SEVCAN AZİME, Ondokuz Mayıs Üniversitesi, and Çukurova Üniversitesi
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Adult ,Male ,myalgia ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Turkish population ,Adolescent ,Turkey ,Familial Mediterranean fever ,Internal medicine ,medicine ,Humans ,Registries ,Child ,Aged ,Aged, 80 and over ,Polyarteritis nodosa ,business.industry ,Amyloidosis ,General Medicine ,Middle Aged ,medicine.disease ,MEFV ,Familial Mediterranean Fever ,Child, Preschool ,Cohort ,Female ,medicine.symptom ,Age of onset ,Colchicine ,Epidemiologic Methods ,business ,Amyloidosis, Familial - Abstract
PubMedID: 15643295 Familial Mediterranean fever (FMF) is an autosomal recessive disease that is prevalent among eastern Mediterranean populations, mainly non-Ashkenazi Jews, Armenians, Turks, and Arabs. Since a large proportion of all the FMF patients in the world live in Turkey, the Turkish FMF Study Group (FMF-TR) was founded to develop a patient registry database and analyze demographic, clinical, and genetic features. The cohort was composed of 2838 patients (mean age, 23.0 ± 13.33 yr; range, 2-87 yr), with a male:female ratio of 1.2:1. There was a mean period of 6.9 ± 7.65 years from disease onset to diagnosis; the period was about 2 years shorter for each decade since 1981. Ninety-four percent of patients were living in the central-western parts of the country; however, their familial origins (70% from the central-eastern and Black Sea regions) reflected not only the ongoing east to west migration, but also the historical roots of FMF in Turkey. Patients' clinical features included peritonitis (93.7%), fever (92.5%), arthritis (47.4%), pleuritis (31.2%), myalgia (39.6%), and erysipelas-like erythema (20.9%). Arthritis, arthralgia, myalgia, and erysipelas-like erythema were significantly more frequent (p < 0.001) among patients with disease onset before the age of 18 years. Genetic analysis of 1090 patients revealed that M694V was the most frequent mutation (51.4%), followed by M680I (14.4%) and V726A (8.6%). Patients with the M694V/M694V genotype were found to have an earlier age of onset and higher frequencies of arthritis and arthralgia compared with the other groups (both p < 0.001). In contrast to other reported studies, there was no correlation between amyloidosis and M694V homozygosity in this cohort. However, amyloidosis was still remarkably frequent in our patients (12.9%), and it was prevalent (27.8%) even among the 18 patients with a disease onset after age 40 years. Twenty-two patients (0.8%) had nonamyloid glomerular diseases. The high prevalence of vasculitides (0.9% for polyarteritis nodosa and 2.7% for Henoch-Schönlein purpura) and high frequency of pericarditis (1.4%) were striking findings in the cohort. Phenotype II cases (those patients with amyloidosis as the presenting or only manifestation of disease) were rare (0.3% or less). There was a high rate of a past diagnosis of acute rheumatic fever, which suggested a possible misdiagnosis in children with FMF presenting with recurrent arthritis. To our knowledge, this is the largest series of patients with FMF reported from 1 country. We describe the features of the disease in the Turkish population and show that amyloidosis is still a substantial problem.
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- 2005
17. Mutational analysis of the PLCE1 gene in steroid resistant nephrotic syndrome
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Boyer, O., primary, Benoit, G., additional, Gribouval, O., additional, Nevo, F., additional, Pawtowski, A., additional, Bilge, I., additional, Bircan, Z., additional, Deschenes, G., additional, Guay-Woodford, L. M., additional, Hall, M., additional, Macher, M.-A., additional, Soulami, K., additional, Stefanidis, C. J., additional, Weiss, R., additional, Loirat, C., additional, Gubler, M.-C., additional, and Antignac, C., additional
- Published
- 2010
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18. Neu-Laxova syndrome: report of a case from Turkey
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Kuseyri, F., primary, Bilge, I., additional, Bilgiç, L., additional, and Apak, M. Y., additional
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- 2008
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19. Inhibition of Listeria monocytogenes by a formulation of selected dairy starter cultures and probiotics in an in vitro model
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Maria Francesca Iulietto, Paola Sechi, Elisa Cella, Luca Grispoldi, Margherita Ceccarelli, Ahmad Rasheed Al Ani, Bilge Işıklar, Haluk M. Anil, and Beniamino Terzo Cenci-Goga
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Biopreservatives ,Enterococcus faecium ,Listeria monocytogenes ,lactic acid bacteria ,Animal culture ,SF1-1100 - Abstract
Three strains of lactic acid bacteria (LAB) and a commercial probiotic were selected to evaluate their in vitro activity towards Listeria monocytogenes. The strains Lactococcus lactis ssp. lactis, strain 340, L. lactis ssp. lactis, strain 16; Lactobacillus casei ssp. casei, strain 208 and Enterococcus faecium UBEF-41 were inoculated into skim milk and brain heart infusion broth (BHI) to get an initial Lactococcus: Lactobacillus: E. faecium UBEF-41 ratio of 2:1:1 and a concentration of approximately 7 log cfu mL−1 until challenge vs. pathogen. L. monocytogenes ATCC 7644 was also inoculated in same media to get approximately 4 log cfu mL−1. Growth curves in skim milk and BHI at 4, 10 and 30 °C, respectively were studied for: (i) LAB formulation; (ii) L. monocytogenes and (iii) LAB vs. L. monocytogenes. When challenged with LAB, at 30 °C in milk, L. monocytogenes was not detectable after day-3 and in BHI it decreased below log cfu mL−1 after day-5. At 10 and 4 °C, in both media, L. monocytogenes counts were always significantly lower (p
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- 2018
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20. Quality of life in children with chronic kidney disease (with child and parent assessments)
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Buyan N, Türkmen MA, Bilge I, Baskin E, Haberal M, Bilginer Y, Mir S, Emre S, Akman S, Ozkaya O, Fidan K, Alpay H, Kavukcu S, Sever L, Özçakar ZB, and Dogrucan N
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- 2010
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21. EULAR/PRINTO/PRES criteria for Henoch-Schönlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part II: final classification criteria.
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Ozen S, Pistorio A, Iusan SM, Bakkaloglu A, Herlin T, Brik R, Buoncompagni A, Lazar C, Bilge I, Uziel Y, Rigante D, Cantarini L, Hilario MO, Silva CA, Alegria M, Norambuena X, Belot A, Berkun Y, Estrella AI, and Olivieri AN
- Published
- 2010
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22. Arterial changes in paediatric haemodialysis patients undergoing renal transplantation.
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Nayir, A, Bilge, I, Kiliçaslan, I, Ander, H, Emre, S, and Sirin, A
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The relationship between primary renal disease and arterial wall changes in paediatric haemodialysis patients has been little studied. The aim of the present work was to determine the influence of primary renal disease on arterial wall pathology in uraemic paediatric patients.
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- 2001
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23. Endovascular treatment of arteriovenous fistulas complicating percutaneous renal biopsy in three paediatric cases.
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Bilge, I, Rozanes, I, Acunas, B, Minareci, O, Nayir, A, Oktem, F, Tonguç, E, Kozok, Y, Emre, S, Ander, H, Sirin, A, and Poyanli, A
- Abstract
We evaluated the incidence and history of arteriovenous fistula (AVF) after kidney biopsy and assessed the use of superselective embolization for treatment.
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- 1999
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24. Comparative Study of Some Numerical Methods for the Burgers–Huxley Equation
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Appanah Rao Appadu, Bilge İnan, and Yusuf Olatunji Tijani
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burgers–huxley equation ,nonstandard finite difference method ,explicit exponential finite difference method ,fully implicit exponential finite difference method ,absolute error ,relative error. ,Mathematics ,QA1-939 - Abstract
In this paper, we construct four numerical methods to solve the Burgers–Huxley equation with specified initial and boundary conditions. The four methods are two novel versions of nonstandard finite difference schemes (NSFD1 and NSFD2), explicit exponential finite difference method (EEFDM) and fully implicit exponential finite difference method (FIEFDM). These two classes of numerical methods are popular in the mathematical biology community and it is the first time that such a comparison is made between nonstandard and exponential finite difference schemes. Moreover, the use of both nonstandard and exponential finite difference schemes are very new for the Burgers–Huxley equations. We considered eleven different combination for the parameters controlling diffusion, advection and reaction, which give rise to four different regimes. We obtained stability region or condition for positivity. The performances of the four methods are analysed by computing absolute errors, relative errors, L 1 and L ∞ errors and CPU time.
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- 2019
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25. Neu-Laxova syndrome: report of a case from Turkey.
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Kuseyri, F., Bilge, I., Bilgiç, L., and Apak, M. Y.
- Published
- 1993
- Full Text
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26. Effect of paraoxonase 1 gene polymorphisms on clinical course of Henoch-Schönlein purpura
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Yilmaz, A., Emre, S., Agachan, B., Bilge, I., Yilmaz, H., arzu ergen, Isbir, T., and Sirin, A.
27. Isolation of dermatophytes from cats and dogs in ankara
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Bilge İşlek Selvi and Murat Yıldırım
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zoonosis ,dermatophytosis ,cats ,dogs ,isolation ,Veterinary medicine ,SF600-1100 - Abstract
Aim: The aim of this study was to determine and identify the dermatophytosis of hair samples taken from Mackenzie's toothbrush technique from cats and dogs without any symptoms in terms of dermatophytosis. Materials and Methods: In our study, the whole body was scanned and hair samples were taken with totthbrush from a total of 120 animals, including 60 cats and 60 dogs. It was examined in light microscope using Potassium Hydroxide (KOH) for direct microscopy. After 3 weeks of incubation in Sabouraud dextrose agar (SDA) and Dermatophyte selective medium (DTM), colony morphologies were examined macroscopically. After that, microscopy was performed using lactophenol cotton blue and cellophane tape method. Results: Dermatophytosis agents were isolated and identified in 25.5% of dogs and 30% of cats in total in 27.5% of the samples. Cat and Dogs. Microsporum spp. (16%) was isolated from Trichophyton spp. (10.8%). When the findings were examined in terms of gender, 34.37% of female cats and 25% of male cats and 34.28% of male cats in female cats were isolated from dermatophytosis. Conclusion: It was observed that the potential transport of dermatophyte agent is frequently present in the skin and feathers of cats and dogs without any clinical findings. Due to the zoonotic character, it was concluded that it would be beneficial to inform the animal owners about this subject in close contact with cats and dogs.
28. EULAR/PRINTO/PRES criteria for Henoch-Schonlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part II: Final classification criteria
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Nicolino Ruperto, Riva Brik, Antonella Buoncompagni, Claudia Sengler, Silvia Pederzoli, Ximena Norambuena, Laura Nuño, Dimitrina Mihaylova, Vyacheslav Chasnyk, Djamal Djeddi, Amparo Ibanez Estrella, Mauricio Alegria, Maria Odete Esteves Hilário, Alexandre Belot, Flavio Sztajnbok, Silvia M. Iusan, Jürgen Brunner, Alma Nunzia Olivieri, Yackov Berkun, Alberto Martini, Ilmay Bilge, Luciana Breda, I. Rumba, Calin Lazar, Donato Rigante, Lana Tambic-Bukovac, Luca Cantarini, Clovis A. Silva, Angela Pistorio, Karaman Pagava, Seza Ozen, MG Alpigiani, Yosef Uziel, Aysin Bakkaloglu, Chris Pruunsild, Sulaiman M. Al-Mayouf, Troels Herlin, Maria Klein-Gitelman, Anuela Kondi, Hacettepe Univ, IRCCS G Gaslini, PRINTO, Aarhus Univ Hosp, Rambam Med Ctr, Clin Pediat 1, Istanbul Univ, Meir Med Ctr, Univ Cattolica Sacro Cuore, Med Clin & Sci Immunol Ist, Universidade Federal de São Paulo (UNIFESP), Universidade de São Paulo (USP), Hosp Ninos Benjamin Bloom, Hosp Dr Exequiel Gonzalez Cortes, Hop Femme Mere Enfant, Safra Childrens Hosp, Inst Salud Nino, Univ Naples 2, IRCCS Ist G Gaslini, Latvian State Univ, Hosp Univ Pedro Ernesto, Univ Zagreb, Univ G dAnnunzio, King Faisal Specialist Hosp & Res Ctr, Univ Children Hosp, Hosp Paediat Dept, Charite, Childrens Mem Hosp, Dept Pediat, Hosp Gen Univ La Paz, Tartu Univ Hosp, Med Univ, Tblisi State Med Univ, Univ Genoa, Ozen, S., Pistorio, A., Iusan, S., Bakkaloglu, A., Herlin, T., Brik, R., Buoncompagni, A., Lazar, C., Bilge, I., Uziel, Y., Rigante, D., Cantarini, L., Hilario, M., Silva, C., Alegria, M., Norambuena, X., Belot, A., Berkun, Y., Estrella, A., Olivieri, Alma Nunzia, Alpigiani, M., Rumba, I., Sztajnbok, F., TAMBIC BUKOVAC, L., Breda, L., AL MAYOUF, S., Mihaylova, D., Chasnyk, V., Sengler, C., KLEIN GITELMAN, M., Djeddi, D., Nuno, L., Pruunsild, C., Brunner, J., Kondi, A., Pagava, K., Pederzoli, S., Martini, A., Ruperto, N., and Çocuk Sağlığı ve Hastalıkları
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Genetics and Molecular Biology (all) ,myalgia ,Vasculitis ,medicine.medical_specialty ,Henoch-Schonlein purpura ,Adolescent ,IgA Vasculitis ,Classification criteria ,International Cooperation ,Immunology ,childhood polyarteritis nodosa ,Biochemistry ,General Biochemistry, Genetics and Molecular Biology ,Rheumatology ,hemic and lymphatic diseases ,Terminology as Topic ,Schoenlein-Henoch ,medicine ,Humans ,Immunology and Allergy ,cardiovascular diseases ,Arteritis ,Child ,Purpura ,c-Wegener granulomatosis ,Epidemiologic Methods ,Granulomatosis with Polyangiitis ,Polyarteritis Nodosa ,Purpura, Schoenlein-Henoch ,Takayasu Arteritis ,Biochemistry, Genetics and Molecular Biology (all) ,criteria ,children ,Henoch-Schönlein purpura ,Wegener granulomatosis ,Takayasu arteritis ,EULAR ,PRINTO ,PRES ,Polyarteritis nodosa ,business.industry ,medicine.disease ,Dermatology ,Surgery ,IgA vasculitis ,Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA ,medicine.symptom ,Granulomatosis with polyangiitis ,business ,Rheumatism ,c-Takayasu arteriti - Abstract
EULAR/PRINTO/PRES Objectives To validate the previously proposed classification criteria for Henoch-Schonlein purpura (HSP), childhood polyarteritis nodosa (c-PAN), c-Wegener granulomatosis (c-WG) and c-Takayasu arteritis (c-TA).Methods Step 1: retrospective/prospective webdata collection for children with HSP, c-PAN, c-WG and c-TA with age at diagnosis
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- 2010
29. Pediatric kidney care experience after the 2023 Türkiye earthquake.
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Bakkaloğlu SA, Delibaş A, Sürmeli Döven S, Taner S, Yavuz S, Erfidan G, Danacı Vatansever E, Aynacı F, Yilmaz K, Taşdemir M, Akacı O, Akıncı N, Güven S, Çiçek N, Dursun I, Keleşoğlu E, Sancaktar M, Alaygut D, Saygılı S, Yavaşcan Ö, Yılmaz A, Gülleroğlu K, Ertan P, Demir BK, Poyrazoğlu H, Pınarbaşı S, Gençler A, Baştuğ F, Günay N, Çeleğen K, Noyan A, Parmaksız G, Avcı B, Çaycı FŞ, Bayrakçı U, Özlü SG, Aksoy ÖY, Yel S, İnal GA, Köse S, Bayazıt AK, Atmış B, Sarıbaş E, Çağlı Ç, Tabel Y, Elmas AT, Zırhlı Selçuk Ş, Demircioğlu Kılıç B, Akbalık Kara M, Büyükçelik M, Balat A, Durucu Tiryaki B, Erdoğdu B, Aksu B, Mahmudova G, Dursun H, Candan C, Göknar N, Mutlubaş F, Çamlar SA, Başaran C, Akbulut BB, Düzova A, Gülhan B, Oruç Ç, Peru H, Alpay H, Türkkan ÖN, Gülmez R, Çelakıl M, Doğan K, Bilge I, Pehlivanoğlu C, Büyükkaragöz B, Leventoğlu E, Alpman N, Zeybek C, Tülpar S, Çiçek Gülşan RY, Kara A, Gürgöze MK, Akyol Önder EN, Özdemir Atikel Y, Pul S, Sönmez F, Yıldız G, Akman S, Elmacı M, Küçük N, Yüksel S, Kavaz A, Nalçacıoğlu H, Alparslan C, Dinçel N, Elhan AH, and Sever L
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- Humans, Child, Female, Male, Adolescent, Child, Preschool, Prognosis, Survival Rate, Follow-Up Studies, Renal Dialysis, Disasters, Infant, Retrospective Studies, Earthquakes, Crush Syndrome therapy, Crush Syndrome complications, Acute Kidney Injury therapy, Acute Kidney Injury etiology
- Abstract
Background: Two earthquakes on 6 February 2023 destroyed 10 cities in Türkiye. We report our experience with pediatric victims during these catastrophes, with a focus on crush syndrome related-acute kidney injury (Crush-AKI) and death., Method: Web-based software was prepared. Patient demographics, time under rubble (TUR), admission laboratory data, dialysis, and kidney and overall outcomes were recorded., Results: A total of 903 injured children (median age 11.62 years) were evaluated. Mean TUR was 13 h (interquartile range 32.5, max 240 h). Thirty-one of 32 patients with a TUR of >120 h survived. The patient who was rescued after 10 days survived. Two-thirds of the patients were given 50 mEq/L sodium bicarbonate in 0.45% sodium chloride solution on admission day. Fifty-eight percent of patients were given intravenous fluid (IVF) at a volume of 2000-3000 mL/m2 body surface area (BSA), 40% at 3000-4000 mL/m2 BSA and only 2% at >4000 mL/m2 BSA. A total of 425 patients had surgeries, and 48 suffered from major bleeding. Amputations were recorded in 96 patients. Eighty-two and 66 patients required ventilator and inotropic support, respectively. Crush-AKI developed in 314 patients (36% of all patients). In all, 189 patients were dialyzed. Age >15 years, creatine phosphokinase (CK) ≥20 950 U/L, TUR ≥10 h and the first-day IVF volume <3000-4000 mL/m2 BSA were associated with Crush-AKI development. Twenty-two deaths were recorded, 20 of 22 occurring in patients with Crush-AKI and within the first 4 days of admission. All patients admitted after 7 days survived., Conclusions: These are the most extensive pediatric kidney disaster data obtained after an earthquake. Serum CK level was significantly associated with Crush-AKI at the levels of >20 950 U/L, but not with death. Adolescent age and initial IVF of less than 3000-4000 mL/m2 BSA were also associated with Crush-AKI. Given that mildly injured victims can survive longer periods in the disaster field, we suggest uninterrupted rescue activity for at least 10 days., (© The Author(s) 2024. Published by Oxford University Press on behalf of the ERA.)
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- 2024
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30. Kidney transplantation in children and adolescents with C3 glomerulopathy or immune complex membranoproliferative glomerulonephritis: a real-world study within the CERTAIN research network.
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Patry C, Webb NJA, Feißt M, Krupka K, Becker J, Bald M, Antoniello B, Bilge I, Gulhan B, Hogan J, Kanzelmeyer N, Ozkaya O, Büscher A, Sellier-Leclerc AL, Shenoy M, Weber LT, Fichtner A, Höcker B, Meier M, and Tönshoff B
- Abstract
Background: Complement 3 glomerulopathy (C3G) and immune complex membranoproliferative glomerulonephritis (IC-MPGN) are ultra-rare chronic kidney diseases with an overall poor prognosis, with approximately 40-50% of patients progressing to kidney failure within 10 years of diagnosis. C3G is characterized by a high rate of disease recurrence in the transplanted kidney. However, there is a lack of published data on clinical outcomes in the pediatric population following transplantation., Methods: In this multicenter longitudinal cohort study of the Cooperative European Paediatric Renal Transplant Initiative (CERTAIN) registry, we compared the post-transplant outcomes of pediatric patients with C3G (n = 17) or IC-MPGN (n = 3) with a matched case-control group (n = 20)., Results: Eleven of 20 children (55%) with C3G or IC-MPGN experienced a recurrence within 5 years post-transplant. Patients with C3G or IC-MPGN had a 5-year graft survival of 61.4%, which was significantly (P = 0.029) lower than the 5-year graft survival of 90% in controls; five patients with C3G or IC-MPGN lost their graft due to recurrence during this observation period. Both the 1-year (20%) and the 5-year (42%) rates of biopsy-proven acute rejection episodes were comparable between patients and controls. Complement-targeted therapy with eculizumab, either as prophylaxis or treatment, did not appear to be effective., Conclusions: These data in pediatric patients with C3G or IC-MPGN show a high risk of post-transplant disease recurrence (55%) and a significantly lower 5-year graft survival compared to matched controls with other primary kidney diseases. These data underscore the need for post-transplant patients for effective and specific therapies that target the underlying disease mechanism., (© 2024. The Author(s).)
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- 2024
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31. The role of anticomplement therapy in the management of the kidney allograft.
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Kanbay M, Copur S, Yilmaz ZY, Baydar DE, Bilge I, Susal C, Kocak B, and Ortiz A
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- Humans, Transplantation, Homologous, Allografts, Graft Rejection drug therapy, Graft Rejection etiology, Graft Rejection prevention & control, Kidney, Kidney Transplantation adverse effects, Complement Inactivator Proteins
- Abstract
As the number of patients living with kidney failure grows, the need also grows for kidney transplantation, the gold standard kidney replacement therapy that provides a survival advantage. This may result in an increased rate of transplantation from HLA-mismatched donors that increases the rate of antibody-mediated rejection (AMR), which already is the leading cause of allograft failure. Plasmapheresis, intravenous immunoglobulin therapy, anti-CD20 therapies (i.e., rituximab), bortezomib and splenectomy have been used over the years to treat AMR as well as to prevent AMR in high-risk sensitized kidney transplant recipients. Eculizumab and ravulizumab are monoclonal antibodies targeting the C5 protein of the complement pathway and part of the expanding field of anticomplement therapies, which is not limited to kidney transplant recipients, and also includes complement-mediated microangiopathic hemolytic anemia, paroxysmal nocturnal hemoglobinuria, and ANCA-vasculitis. In this narrative review, we summarize the current knowledge concerning the pathophysiological background and use of anti-C5 strategies (eculizumab and ravulizumab) and C1-esterase inhibitor in AMR, either to prevent AMR in high-risk desensitized patients or to treat AMR as first-line or rescue therapy and also to treat de novo thrombotic microangiopathy in kidney transplant recipients., (© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
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- 2024
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32. Urine soluble TLR4 levels may contribute to predict urinary tract infection in children: the UTILISE Study.
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Aksu B, Afonso AC, Akil I, Alpay H, Atmis B, Aydog O, Bayazıt AK, Bayram MT, Bilge I, Bulut IK, Buyukkaragoz B, Comak E, Demir BK, Dincel N, Donmez O, Durmus MA, Dursun H, Dusunsel R, Duzova A, Ertan P, Gedikbasi A, Goknar N, Guven S, Hacihamdioglu D, Jankauskiene A, Kalyoncu M, Kavukcu S, Kenan BU, Kucuk N, Kural B, Litwin M, Montini G, Morello W, Obrycki L, Omer B, Oner HA, Ozdemir EM, Ozkayin N, Paripovic D, Pehlivanoglu C, Saygili S, Schaefer F, Schaefer S, Sonmez F, Tabel Y, Tas N, Tasdemir M, Teixeira A, Tekcan D, Topaloglu R, Tulpar S, Turkkan ON, Uysal B, Uysalol M, Vitkevic R, Yavuz S, Yel S, Yildirim T, Yildirim ZY, Yildiz N, Yuksel S, Yurtseven E, and Yilmaz A
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- Child, Humans, Interleukin-8 urine, Toll-Like Receptor 4, Biomarkers, Urinary Tract Infections diagnosis, Urinary Tract Infections urine, Pyelonephritis diagnosis
- Abstract
Background: One of the most common bacterial infections in childhood is urinary tract infection (UTI). Toll-like receptors (TLRs) contribute to immune response against UTI recognizing specific pathogenic agents. Our aim was to determine whether soluble TLR4 (sTLR4), soluble TLR5 (sTLR5) and interleukin 8 (IL-8) can be used as biomarkers to diagnose UTI. We also aimed to reveal the relationship between urine Heat Shock Protein 70 (uHSP70) and those biomarkers investigated in this study., Methods: A total of 802 children from 37 centers participated in the study. The participants (n = 282) who did not meet the inclusion criteria were excluded from the study. The remaining 520 children, including 191 patients with UTI, 178 patients with non-UTI infections, 50 children with contaminated urine samples, 26 participants with asymptomatic bacteriuria and 75 healthy controls were included in the study. Urine and serum levels of sTLR4, sTLR5 and IL-8 were measured at presentation in all patients and after antibiotic treatment in patients with UTI., Results: Urine sTLR4 was higher in the UTI group than in the other groups. UTI may be predicted using 1.28 ng/mL as cut-off for urine sTLR4 with 68% sensitivity and 65% specificity (AUC = 0.682). In the UTI group, urine sTLR4 levels were significantly higher in pyelonephritis than in cystitis (p < 0.0001). Post-treatment urine sTLR4 levels in the UTI group were significantly lower than pre-treatment values (p < 0.0001)., Conclusions: Urine sTLR4 may be used as a useful biomarker in predicting UTI and subsequent pyelonephritis in children with UTI. A higher resolution version of the Graphical abstract is available as Supplementary information., (© 2023. The Author(s), under exclusive licence to International Pediatric Nephrology Association.)
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- 2024
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33. Urinary HSP70 improves diagnostic accuracy for urinary tract infection in children: UTILISE study.
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Yilmaz A, Afonso AC, Akil I, Aksu B, Alpay H, Atmis B, Aydog O, Bayazıt AK, Bayram MT, Bilge I, Bulut IK, Buyukkaragoz B, Comak E, Demir BK, Dincel N, Donmez O, Durmus MA, Dursun H, Dusunsel R, Duzova A, Ertan P, Gedikbasi A, Goknar N, Guven S, Hacihamdioglu D, Jankauskiene A, Kalyoncu M, Kavukcu S, Kenan BU, Kucuk N, Kural B, Litwin M, Montini G, Morello W, Nayir A, Obrycki L, Omer B, Ozdemir EM, Ozkayin N, Paripovic D, Pehlivanoglu C, Saygili S, Schaefer S, Sonmez F, Tabel Y, Tas N, Tasdemir M, Teixeira A, Tekcan D, Tulpar S, Turkkan ON, Uysal B, Uysalol M, Vaiciuniene D, Yavuz S, Yel S, Yildirim T, Yildirim ZY, Yildiz N, Yuksel S, Yurtseven E, Schaefer F, and Topaloglu R
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- Humans, Child, Urinalysis, Anti-Bacterial Agents therapeutic use, HSP70 Heat-Shock Proteins, Sensitivity and Specificity, Urinary Tract Infections drug therapy, Urinary Tract
- Abstract
Background: The accuracy of conventional urinalysis in diagnosing urinary tract infection (UTI) in children is limited, leading to unnecessary antibiotic exposure in a large fraction of patients. Urinary heat shock protein 70 (uHSP70) is a novel marker of acute urinary tract inflammation. We explored the added value of uHSP70 in discriminating UTI from other infections and conditions confused with UTI., Methods: A total of 802 children from 37 pediatric centers in seven countries participated in the study. Patients diagnosed with UTI (n = 191), non-UTI infections (n = 178), contaminated urine samples (n = 50), asymptomatic bacteriuria (n = 26), and healthy controls (n = 75) were enrolled. Urine and serum levels of HSP70 were measured at presentation in all patients and after resolution of the infection in patients with confirmed UTI., Results: Urinary (u)HSP70 was selectively elevated in children with UTI as compared to all other conditions (p < 0.0001). uHSP70 predicted UTI with 89% sensitivity and 82% specificity (AUC = 0.934). Among the 265 patients with suspected UTI, the uHSP70 > 48 ng/mL criterion identified the 172 children with subsequently confirmed UTI with 90% sensitivity and 82% specificity (AUC = 0.862), exceeding the individual diagnostic accuracy of leukocyturia, nitrite, and leukocyte esterase positivity. uHSP70 had completely normalized by the end of antibiotic therapy in the UTI patients. Serum HSP70 was not predictive., Conclusions: Urine HSP70 is a novel non-invasive marker of UTI that improves the diagnostic accuracy of conventional urinalysis. We estimate that rapid urine HSP70 screening could spare empiric antibiotic administration in up to 80% of children with suspected UTI. A higher resolution version of the Graphical abstract is available as Supplementary information., (© 2022. The Author(s), under exclusive licence to International Pediatric Nephrology Association.)
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- 2023
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34. COVID-19 in pediatric nephrology centers in Turkey.
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Leventoğlu E, Özdemir Atikel Y, Nalçacioğlu H, Dursun İ, Dursun H, Yürük Yildirim Z, Yildiz N, Kaya Aksoy G, Taşdemir M, Çelakil M, Demircioğlu Kiliç B, Zirhli Selçuk Ş, Canpolat N, Kargin Çakici E, Özlü SG, Tülpar S, Yüksel S, Atmiş B, Sürmeli Döven S, Taner S, Ertan P, Kavaz A, Torun Bayram M, Kalyoncu M, Gülleroğlu K, Kabasakal C, Kasap Demir B, Çiçek RY, Bilge I, Dönmez O, Kara A, Yavaşcan Ö, Özçelik G, Gezgin Yildirim D, Güler MA, Sönmez F, Poyrazoğlu H, Akman S, Topaloğlu R, Alpay H, and Bakkaloğlu SA
- Abstract
Background/aim: There is limited data on COVID-19 disease in children with kidney disease. We aimed to investigate the characteristics and prognosis of COVID-19 in pediatric nephrology patients in Turkey., Materials and Methods: This was a national, multicenter, retrospective cohort study based on an online survey evaluating the data between 11
th March 2020 and 11th March 2021 as an initial step of a detailed pediatric nephrology COVID-19 registry., Results: Two hundred and three patients (89 girls and 114 boys) were diagnosed with COVID-19. One-third of these patients (36.9%) were between 10-15 years old. Half of the patients were on kidney replacement therapy: kidney transplant (KTx) recipients (n = 56, 27.5%), patients receiving chronic hemodialysis (n = 33, 16.3%) and those on peritoneal dialysis (PD) (n = 18, 8.9%). Fifty-four (26.6%) children were asymptomatic. Eighty-two (40.3%) patients were hospitalized and 23 (28%) needed intensive care unit admission. Fifty-five percent of the patients were not treated, while the remaining was given favipiravir (20.7%), steroid (16.3%), and hydroxychloroquine (11.3%). Acute kidney injury developed in 19.5% of hospitalized patients. Five (2.4%) had MIS-C. Eighty-three percent of the patients were discharged without any apparent sequelae, while 7 (3.4%) died. One hundred and eight health care staff were infected during the study period., Conclusion: COVID-19 was most commonly seen in patients who underwent KTx and received HD. The combined immunosuppressive therapy and frequent exposure to the hospital setting may increase these patients' susceptibility. Staff infections before vaccination era were alarming, various precautions should be taken for infection control, particularly optimal vaccination coverage., (© TÜBİTAK.)- Published
- 2022
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35. Clinical and molecular evaluation of MEFV gene variants in the Turkish population: a study by the National Genetics Consortium.
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Dundar M, Fahrioglu U, Yildiz SH, Bakir-Gungor B, Temel SG, Akin H, Artan S, Cora T, Sahin FI, Dursun A, Sezer O, Gurkan H, Erdogan M, Gunduz CNS, Bisgin A, Ozdemir O, Ulgenalp A, Percin EF, Yildirim ME, Tekes S, Bagis H, Yuce H, Duman N, Bozkurt G, Yararbas K, Yildirim MS, Arman A, Mihci E, Eraslan S, Altintas ZM, Aymelek HS, Ruhi HI, Tatar A, Ergoren MC, Cetin GO, Altunoglu U, Caglayan AO, Yuksel B, Ozkul Y, Saatci C, Kenanoglu S, Karasu N, Dundar B, Ozcelik F, Demir M, Siniksaran BS, Kulak H, Kiranatlioglu K, Baysal K, Kazimli U, Akalin H, Dundar A, Boz M, Bayram A, Subasioglu A, Colak FK, Karaduman N, Gunes MC, Kandemir N, Aynekin B, Emekli R, Sahin IO, Ozdemir SY, Onal MG, Senel AS, Poyrazoglu MH, Kisaarslan ANP, Gursoy S, Baskol M, Calis M, Demir H, Zararsiz GE, Erdogan MO, Elmas M, Solak M, Ulu MS, Thahir A, Aydin Z, Atasever U, Sag SO, Aliyeva L, Alemdar A, Dogan B, Erguzeloglu CO, Kaya N, Ozkinay F, Cogulu O, Durmaz A, Onay H, Karaca E, Durmaz B, Aykut A, Cilingir O, Aras BD, Gokalp EE, Arslan S, Temena A, Haziyeva K, Kocagil S, Bas H, Susam E, Keklikci AR, Sarac E, Kocak N, Nergiz S, Terzi YK, Dincer SA, Baskin ES, Genc GC, Bahadir O, Sanri A, Yigit S, Tozkir H, Yalcintepe S, Ozkayin N, Kiraz A, Balta B, Gonen GA, Kurt EE, Ceylan GG, Ceylan AC, Erten S, Bozdogan ST, Boga I, Yilmaz M, Silan F, Kocabey M, Koc A, Cankaya T, Bora E, Bozkaya OG, Ercal D, Ergun MA, Ergun SG, Duman YS, Beyazit SB, Uzel VH, Em S, Cevik MO, Eroz R, Demirtas M, Firat CK, Kabayegit ZM, Altan M, Mardan L, Sayar C, Tumer S, Turkgenc B, Karakoyun HK, Tunc B, Kuru S, Zamani A, Geckinli BB, Ates EA, Clark OA, Toylu A, Coskun M, Nur B, Bilge I, Bayramicli OU, Emmungil H, Komesli Z, Zeybel M, Gurakan F, Tasdemir M, Kebudi R, Karabulut HG, Tuncali T, Kutlay NY, Kahraman CY, Onder NB, Beyitler I, Kavukcu S, Tulay P, Tosun O, Tuncel G, Mocan G, Kale H, Uyguner ZO, Acar A, Altinay M, and Erdem L
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- Genetics, Population, Genotype, Humans, Mutation, Phenotype, Turkey epidemiology, Familial Mediterranean Fever epidemiology, Familial Mediterranean Fever genetics, Pyrin genetics
- Abstract
Familial Mediterranean fever (FMF) is a monogenic autoinflammatory disorder with recurrent fever, abdominal pain, serositis, articular manifestations, erysipelas-like erythema, and renal complications as its main features. Caused by the mutations in the MEditerranean FeVer (MEFV) gene, it mainly affects people of Mediterranean descent with a higher incidence in the Turkish, Jewish, Arabic, and Armenian populations. As our understanding of FMF improves, it becomes clearer that we are facing with a more complex picture of FMF with respect to its pathogenesis, penetrance, variant type (gain-of-function vs. loss-of-function), and inheritance. In this study, MEFV gene analysis results and clinical findings of 27,504 patients from 35 universities and institutions in Turkey and Northern Cyprus are combined in an effort to provide a better insight into the genotype-phenotype correlation and how a specific variant contributes to certain clinical findings in FMF patients. Our results may help better understand this complex disease and how the genotype may sometimes contribute to phenotype. Unlike many studies in the literature, our study investigated a broader symptomatic spectrum and the relationship between the genotype and phenotype data. In this sense, we aimed to guide all clinicians and academicians who work in this field to better establish a comprehensive data set for the patients. One of the biggest messages of our study is that lack of uniformity in some clinical and demographic data of participants may become an obstacle in approaching FMF patients and understanding this complex disease., (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2022
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36. Improving the urine spot protein/creatinine ratio by the estimated creatinine excretion to predict proteinuria in pediatric kidney transplant recipients.
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Incir S, Tasdemir M, Kocak B, Yelken B, Arpali E, Akyollu B, Palaoglu KE, Baygul A, Bilge I, and Turkmen A
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- Biomarkers urine, Child, Female, Humans, Kidney Function Tests, Male, Creatinine urine, Kidney Transplantation, Postoperative Complications diagnosis, Proteinuria diagnosis
- Abstract
Background: Since the daily creatinine excretion rate (CER) is directly affected by muscle mass, which varies with age, gender, and body weight, using the spot protein/creatinine ratio (Spot P/Cr) follow-up of proteinuria may not always be accurate. Estimated creatinine excretion rate (eCER) can be calculated from spot urine samples with formulas derived from anthropometric factors. Multiplying Spot P/Cr by eCER gives the estimated protein excretion rate (ePER). We aimed to determine the most applicable equation for predicting daily CER and examine whether ePER values acquired from different equations can anticipate measured 24 h urine protein (m24 h UP) better than Spot P/Cr in pediatric kidney transplant recipients., Methods: This study enrolled 23 children with kidney transplantation. To estimate m24 h UP, we calculated eCER and ePER values with three formulas adapted to children (Cockcroft-Gault, Ghazali-Barratt, and Hellerstein). To evaluate the accuracy of the methods, Passing-Bablok and Bland-Altman analysis were used., Results: A statistically significant correlation was found between m24 h UP and Spot P/Cr (p < .001, r = 0.850), and the correlation was enhanced by multiplying the Spot P/Cr by the eCER equations. The average bias of the ePER formulas adjusted by the Cockcroft-Gault, Ghazali-Barratt, and Hellerstein equations were -0.067, 0.031, and 0.064 g/day, respectively, whereas the average bias of Spot P/Cr was -0.270 g/day obtained by the Bland-Altman graphics., Conclusion: Using equations to estimate eCER may improve the accuracy and reduce the spot urine samples' bias in pediatric kidney transplantation recipients. Further studies in larger populations are needed for ePER reporting to be ready for clinical practice., (© 2021 Wiley Periodicals LLC.)
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- 2021
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37. PROGRESS STUDY: Progression of chronic kidney disease in children and heat shock proteins.
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Yuruk Yildirim ZN, Usta Akgul S, Alpay H, Aksu B, Savran Oguz F, Kiyak A, Akinci N, Yavuz S, Ozcelik G, Gedikbasi A, Gokce I, Ozkayin N, Yildiz N, Pehlivanoglu C, Goknar N, Saygili S, Tulpar S, Kucuk N, Bilge I, Tasdemir M, Agbas A, Dirican A, Emre S, Nayir A, and Yilmaz A
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- Apoptosis genetics, Chaperonin 60 blood, Chaperonin 60 urine, Child, Child, Preschool, Endothelial Cells metabolism, Endothelial Cells pathology, Female, HSP27 Heat-Shock Proteins blood, HSP27 Heat-Shock Proteins urine, HSP40 Heat-Shock Proteins blood, HSP40 Heat-Shock Proteins urine, HSP47 Heat-Shock Proteins blood, HSP47 Heat-Shock Proteins urine, HSP70 Heat-Shock Proteins blood, HSP70 Heat-Shock Proteins urine, HSP72 Heat-Shock Proteins blood, HSP72 Heat-Shock Proteins urine, HSP90 Heat-Shock Proteins blood, HSP90 Heat-Shock Proteins urine, Heat-Shock Proteins genetics, Humans, Inflammation blood, Inflammation genetics, Inflammation urine, Male, Oxidative Stress genetics, Renal Insufficiency, Chronic blood, Renal Insufficiency, Chronic pathology, Renal Insufficiency, Chronic urine, Heat-Shock Proteins blood, Heat-Shock Proteins urine, Inflammation diagnosis, Renal Insufficiency, Chronic diagnosis
- Abstract
Various molecular and cellular processes are involved in renal fibrosis, such as oxidative stress, inflammation, endothelial cell injury, and apoptosis. Heat shock proteins (HSPs) are implicated in the progression of chronic kidney disease (CKD). Our aim was to evaluate changes in urine and serum HSP levels over time and their relationships with the clinical parameters of CKD in children. In total, 117 children with CKD and 56 healthy children were examined. The CKD group was followed up prospectively for 24 months. Serum and urine HSP27, HSP40, HSP47, HSP60, HSP70, HSP72, and HSP90 levels and serum anti-HSP60 and anti-HSP70 levels were measured by ELISA at baseline, 12 months, and 24 months. The urine levels of all HSPs and the serum levels of HSP40, HSP47, HSP60, HSP70, anti-HSP60, and anti-HSP70 were higher at baseline in the CKD group than in the control group. Over the months, serum HSP47 and HSP60 levels steadily decreased, whereas HSP90 and anti-HSP60 levels steadily increased. Urine HSP levels were elevated in children with CKD; however, with the exception of HSP90, they decreased over time. In conclusion, our study demonstrates that CKD progression is a complicated process that involves HSPs, but they do not predict CKD progression. The protective role of HSPs against CKD may weaken over time, and HSP90 may have a detrimental effect on the disease course., (© 2021. Cell Stress Society International.)
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- 2021
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38. Rituximab treatment for difficult-to-treat nephrotic syndrome in children: a multicenter, retrospective study
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Taşdemir M, Canpolat N, Yıldız N, Özçelik G, Benzer M, Saygılı SK, Özkayin EN, Türkkan ÖN, Balat A, Candan C, Çelakıl M, Yavuz S, Akıncı N, Göknar N, Akgün C, Tülpar S, Alpay H, Sever FL, and Bilge İ
- Subjects
- Adolescent, Child, Child, Preschool, Female, Humans, Infant, Male, Recurrence, Retrospective Studies, Treatment Outcome, Immunosuppressive Agents therapeutic use, Nephrotic Syndrome drug therapy, Rituximab therapeutic use, Steroids therapeutic use
- Abstract
Background/aim: This study aimed to evaluate the efficacy of rituximab in children with difficult-to-treat nephrotic syndrome, considering the type of disease (steroid-sensitive or –resistant) and the dosing regimen., Materials and Methods: This multicenter retrospective study enrolled children with difficult-to-treat nephrotic syndrome on rituximab treatment from 13 centers. The patients were classified based on low (single dose of 375 mg/m2) or high (2-4 doses of 375 mg/m2) initial dose of rituximab and the steroid response. Clinical outcomes were compared., Results: Data from 42 children [20 steroid-sensitive (frequent relapsing / steroid-dependent) and 22 steroid-resistant nephrotic syndrome, aged 1.9–17.3 years] were analyzed. Eleven patients with steroid-sensitive nephrotic syndrome (55%) had a relapse following initial rituximab therapy, with the mean time to first relapse of 8.4 ± 5.2 months. Complete remission was achieved in 41% and 36% of steroid-resistant patients, with the median remission time of 3.65 months. At Year 2, eight patients in steroid-sensitive group (40%) and four in steroid-resistant group (18%) were drug-free. Total cumulative doses of rituximab were higher in steroid-resistant group (p = 001). Relapse rates and time to first relapse in steroid-sensitive group or remission rates in steroid-resistant group did not differ between the low and high initial dose groups., Conclusion: The current study reveals that rituximab therapy may provide a lower relapse rate and prolonged relapse-free survival in the steroid-sensitive group, increased remission rates in the steroid-resistant group, and a significant number of drug-free patients in both groups. The optimal regimen for initial treatment and maintenance needs to be determined., (This work is licensed under a Creative Commons Attribution 4.0 International License.)
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- 2021
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39. Adaptive analysis of cortical plasticity with fMRI in full face and arm transplants.
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Şavklıyıldız A, Özkan Ö, Uysal H, Şenol U, Özkan Ö, Doğan EA, Barçın E, Bilge İ, Gök K, Döğer EN, Şimşek B, Carlak HF, Polat Ö, and Çolak ÖH
- Subjects
- Brain Mapping, Hand, Humans, Neuronal Plasticity, Parietal Lobe, Somatosensory Cortex diagnostic imaging, Arm, Magnetic Resonance Imaging
- Abstract
The aim of this study is to examine cortical plasticity and to analyze cortical reorganization following hand and facial transplantation, using functional magnetic resonance imaging. Patients who had undergone full-face transplantation, hand transplantation and scapular arm replantation, as well as healthy controls, participated in the study. The perioral area and volar surfaces of the index finger and thumb were stimulated and images were acquired using 3 T functional MRI. The areas of the somatosensory cortex representing the hand and face are different in size and shape due to experience-dependent plasticity. Therefore, a new and more adaptive volume of interest analysis was created whereby the radiuses of the VOI masks were defined by the peak intensity of subsequent clusters. For each control subject, the distribution of activated voxels was observed for various cluster defining thresholds in order to determine the mean number of activated voxels for each stimulation inside the defined region. The determined numbers of voxels per subject were extracted from the defined regions using a binary search algorithm. Subsequently, the distances between the weighted centers of the extracted regions were calculated and compared. In transplant patients, the weighted centers of the hand and face clusters were separated at same-sized volumes. Two of the rehabilitated full-face transplant patients converge to the range of the controls. As a result, the weighted distribution of somatotopy indicated previous and present cortical reorganization. Additionally, referred sensation was assessed in two full-face transplant and one replant patient with activation clusters partially in BA40 in the Inferior Parietal Lobule., (© 2020. Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2021
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40. Metabolic acidosis with increased anion gap, oxaluria, and acute kidney injury: Questions.
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Aksu B, Rahimov E, Yilmaz A, Yildirim ZY, Bilge I, Emre S, and Sirin A
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- 2021
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41. Metabolic acidosis with increased anion gap, oxaluria, and acute kidney injury: Answers.
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Aksu B, Rahimov E, Yilmaz A, Yildirim ZY, Bilge I, Emre S, and Sirin A
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- 2021
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42. Macrophage Activation Syndrome in a Child with Juvenile Idiopathic Arthritis Secondary to SARS-CoV-2.
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Akturk H, Tanyildiz M, Erbey F, Tasdemir M, Celikyurt A, Gonen E, and Bilge I
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- Child, Humans, Pandemics, SARS-CoV-2, Arthritis, Juvenile complications, COVID-19, Macrophage Activation Syndrome diagnosis, Macrophage Activation Syndrome etiology
- Abstract
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused a pandemic affecting many countries and millions of people. Physicians have encountered some rare and challenging cases related to SARS-CoV-2, a novel virus with still many unknowns. In order to share our experience of a such clinical picture, we present here a child with SARS-CoV-2-induced macrophage activation syndrome in the setting of juvenile idiopathic arthritis., (© The Author(s) [2021]. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
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- 2021
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43. Is there a unique symptom in lower urinary tract dysfunction in children?
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Özen MA, Taşdemir M, Aygün MS, Necef I, Aydın E, Bilge I, and Eroğlu E
- Subjects
- Child, Female, Humans, Ultrasonography, Lower Urinary Tract Symptoms diagnosis, Lower Urinary Tract Symptoms etiology, Urinary Bladder, Overactive diagnosis, Urination Disorders diagnosis, Urination Disorders etiology
- Abstract
Objectives: Lower urinary tract symptoms (LUTS), particularly urgency, incontinence and intermittency are common in children and it is suggested that the specific symptoms may be used for definite diagnosis for LUT dysfunction (LUTD). This study was performed to investigate the relationship between each LUTD and its associated symptoms, using uroflowmetry/electromyography (UF/EMG) as a diagnostic tool., Methods: Each patient was categorized into one of four LUT conditions which were overactive bladder (OAB), dysfunctional voiding (DV), underactive bladder and primary bladder neck dysfunction (PBND), according to UF/EMG results. Patients' complaints and findings were documented by using voiding dysfunction symptom score, bladder diary, urine analysis and ultrasonography. In addition, a detailed history of bowel habits (including use of Rome III criteria) was obtained., Results: There were 189 children of which 106 were female. The OAB was the largest group including 91 patients, followed by the DV group which had 61 patients. The symptoms specific to any LUTD group were constipation and hesitancy (P < .05). Hesitancy was present in 89.4% with PBND and constipation was present in 78.6% of patients with DV. None of other symptoms were able to differentiate any LUTD group from the other., Conclusions: While certain symptoms are often presumed by clinicians to imply specific diagnoses, the main outcome of this study is that there is a generally weak correlation between the specificity of symptoms and LUTD. Symptoms-based approach may lead to misdiagnosis in LUTD. Thus, it may be essential to focus on the underlying pathologies and UF/EMG test may help this., (© 2020 John Wiley & Sons Australia, Ltd.)
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- 2021
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44. Different approaches among physicians to treat pediatric stone disease: a survey-based study.
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Önal B, Kırlı EA, Canpolat N, Taşdemir M, Gürbüz A, Özman O, Sever L, Bilge I, and Çalışkan S
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- Child, Humans, Surveys and Questionnaires, Treatment Outcome, Ureteroscopy, Kidney Calculi diagnosis, Kidney Calculi therapy, Lithotripsy, Physicians
- Abstract
Introduction: Pediatricians, surgeons and subspecialties as pediatric urology and nephrology are involved in the diagnosis and treatment of pediatric renal stone disease (RSD). The aim of this study was to determine diagnostic and treatment approaches, of different disciplines, and to assess differences in their routine diagnostic and treatment protocols., Population and Methods: A questionnaire was designed and administered to the participants of the RSD sessions in national congresses of all disciplines in 2017 to evaluate the diagnostic and treatment routines of specialties (surgeons and pediatricians) and subspecialties (pediatric nephrologists and pediatric urologists) for RSD., Results: A total, of 324 questionnaires were analyzed, from 88 pediatricians (27 %), 121 urologists (37 %), 23 pediatric surgeons (7 %), 54 pediatric nephrologists (17 %), and 38 pediatric urologists (12 %). Both groups agreed on the necessity of metabolic evaluation. For distal ureter stones that were ≥ 6 mm; surgeons preferred ureteroscopy (URS), pediatricians preferred shock wave lithotripsy (SWL) (p < 0.001) and subspecialties preferred URS for the treatment (p = 0.636). For lower calix stones less than 1 cm surgeons and subspecialists preferred SWL, while pediatricians preferred hydration (p < 0.001, p = 0.371). For the stone between 1.1 and 2 cm, surgeons preferred intrarenal surgery (RIRS) and SWL, pediatricians preferred SWL (p = 0.001). For larger stones, surgeons and subspecialists preferred percutaneous nephrolithotomy (PCNL), and pediatricians preferred SWL (p = 0.458 p = 0.001). Pediatric urologist chose low-dose computerized tomography as a diagnostic radiologic evaluation (p = 0.029)., Conclusion: There are differences between the disciplines who take an active role in diagnosis and treatment of RSD., Competing Interests: None, (Sociedad Argentina de Pediatría.)
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- 2021
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45. An 8-month-old infant with hypercalcemia and hyperphosphatemia: Questions.
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Özler O, Mutlu GY, Taşdemir M, Avcı Ş, Bilge I, and Hatun Ş
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- 2021
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46. A chromosome-scale genome assembly of European hazel (Corylus avellana L.) reveals targets for crop improvement.
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Lucas SJ, Kahraman K, Avşar B, Buggs RJA, and Bilge I
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- Corylus genetics, Genome Size genetics, Plant Proteins genetics, Corylus metabolism, Plant Proteins metabolism
- Abstract
The European hazelnut (Corylus avellana L.) is a tree crop of economic importance worldwide, but especially for northern Turkey, where the majority of production takes place. Hazelnut production is currently challenged by environmental stresses, such as a recent outbreak of severe powdery mildew disease; furthermore, allergy to hazelnuts is an increasing health concern in some regions. In order to provide a foundation for using the available hazelnut genetic resources for crop improvement, we produced a fully assembled genome sequence and annotation for a hazelnut species, from C. avellana cv. 'Tombul', one of the most important Turkish varieties. A hybrid sequencing strategy, combining short reads, long reads and proximity ligation methods, enabled us to resolve heterozygous regions and produce a high-quality 370-Mb assembly that agrees closely with cytogenetic studies and genetic maps of the 11 C. avellana chromosomes, and covers 97.8% of the estimated genome size. The genome includes 27 270 high-confidence protein-coding genes, over 20 000 of which were functionally annotated based on homology with known plant proteins. We focused particularly on gene families encoding hazelnut allergens, and the Mildew resistance Locus O (MLO) proteins that are an important susceptibility factor for powdery mildew. The complete assembly enabled us to differentiate between members of these families and to identify homologues that may be important in mildew disease and hazelnut allergy. These findings provide examples of how the genome can be used to guide research and to develop effective strategies for crop improvement in C. avellana., (© 2020 Society for Experimental Biology and John Wiley & Sons Ltd.)
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- 2021
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47. An 8-month-old infant with hypercalcemia and hyperphosphatemia-Answers.
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Özler O, Mutlu GY, Taşdemir M, Avcı Ş, Bilge I, and Hatun Ş
- Published
- 2021
- Full Text
- View/download PDF
48. Symptomatology and Clinic of Hydronephrosis Associated With Uretero Pelvic Junction Anomalies.
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Bilge I
- Abstract
The most common cause of hydronephrosis in the pediatric age group is ureteropelvic junction-type hydronephrosis (UPJHN). Since the advent of widespread maternal ultrasound screening, clinical presentation of hydronephrosis associated with UPJ anomalies has changed dramatically. Today most cases are diagnosed in the prenatal period, and neonates present without signs or symptoms. For those who are not detected at birth, UPJHN eventually presents throughout childhood and even adulthood with various symptoms. Clinical picture of UPJHN highly depends on the presence and severity of obstruction, and whether it affects single or both kidneys. Abdominal or flank pain, abdominal mass, hematuria, kidney stones, urinary tract infections (UTI), and gastrointestinal discomfort are the main symptoms of UPJHN in childhood. Other less common findings in such patients are growth retardation, anemia, and hypertension. UTI is a relatively rare condition in UPJHN cases, but it may occur as pyelonephritis. Vesicoureteric reflux should be kept in mind as a concomitant pathology in pediatric UPJHN that develop febrile UTI. Although many UPJHN cases are known to improve over time, close clinical observation is critical in order to avoid irreversible kidney damage. The most appropriate approach is to follow-up the patients considering the presence of symptoms, the severity of hydronephrosis and the decrease in kidney function and, if necessary, to decide on early surgical intervention., (Copyright © 2020 Bilge.)
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- 2020
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49. Maintenance Peritoneal Dialysis in Children With Autosomal Recessive Polycystic Kidney Disease: A Comparative Cohort Study of the International Pediatric Peritoneal Dialysis Network Registry.
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Akarkach A, Burgmaier K, Sander A, Hooman N, Sever L, Cano F, Zambrano P, Bilge I, Flynn JT, Yavascan O, Vallés PG, Munarriz RL, Patel HP, Serdaroglu E, Koch VH, Suarez ADC, Galanti M, Celedon CG, Rébori A, Kari JA, Wong CJ, Elenberg E, Rojas LF, Warady BA, Liebau MC, and Schaefer F
- Subjects
- Child, Child, Preschool, Female, Follow-Up Studies, Humans, Infant, Male, Polycystic Kidney, Autosomal Recessive complications, Renal Insufficiency etiology, Time Factors, Treatment Outcome, Peritoneal Dialysis methods, Polycystic Kidney, Autosomal Recessive therapy, Registries, Renal Insufficiency prevention & control
- Published
- 2020
- Full Text
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50. A rare cause of chronic hyponatremia in an infant: Questions.
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Mutlu GY, Taşdemir M, Kızılkan NU, Güran T, Hatun Ş, Kayserili H, and Bilge I
- Published
- 2020
- Full Text
- View/download PDF
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