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43 results on '"Bilal, Haris"'

1. Effect of colchicine on perioperative atrial fibrillation and myocardial injury after non-cardiac surgery in patients undergoing major thoracic surgery (COP-AF): an international randomised trial

Author

Conen, David, Devereaux, PJ, Vincent, Jessica, Wang, Michael Ke, Wells, Jennifer R., Healey, Jeff S., Landoni, Giovanni, McIntyre, William F., Popova, Ekaterine, Sessler, Daniel I., Srinathan, Sadeesh K., Amir, Mohammed, Bangdiwala, Shrikant I., Bossard, Matthias, Chan, Matthew TV, Eikelboom, John W., Fleischmann, Edith, Jolly, Sanjit, Montes, Felix Ramón, Reimer, Cara, Schmartz, Denis, Wang, Chew Yin, Ofori, Sandra N., Blum, Steffen, Alvarez-Garcia, Jesus, Lo Bianco, Giuliana, Traquair, Hugh, Guerrero-Pinedo, Fernando Andres, Oleynick, Christopher, Meyre, Pascal B., Méndez-Zurita, Francisco, Chiarella-Redfern, Helene, Marcucci, Maura, Donati, Francesco, Gonzalez-Osuna, Aranzazu, Minervini, Fabrizio, Moreno Weidmann, Zoraida, Guerra-Ramos, Jose M., Dion, Gabriel, Ramos-Pachón, Anna, Borges, Flavia K., de Sa Boasquevisque, Danielle, Mosconi, Maria Giulia, Amarenco, Pierre, Mitchell, L. Brent, Wyse, George, Cheng, Davy, McAlister, Finlay A., Wells, George A., Baskaran, Geethan, Burns, Andrew T., Gennaccaro, Julia, Howe, Rosemary, Mastrangelo, Louise, Pettit, Shirley, Popovic, Michelle, Shahbaz, Subana, Tosh, Makayla, Zucchetto, Simona J., Heenan, Laura, Lee, Shun Fu, Li, Zhuoru, Xu, Lizhen, Kabon, Barbara, Hoetzenecker, Konrad, Schweiger, Thomas, Reiterer, Christian, Zotti, Oliver, Bsuchner, Paul, Hochreiter, Beatrix, Taschner, Alexander, Adamowitsch, Nikolas, Horvath, Katharina, Hantáková, Nicole, Bidgoli, Javad, Huybrechts, Isabelle, Cappeliez, Serge, Neary, John D., Shargall, Yaron, Tandon, Vikas, Finley, Christian, Agzarian, John, Hanna, Waël, Abdulrahman, Muammar, Lawrence, Kelly, Gregus, Krysten, Quraishi, Faraaz, Wikkerink, Spencer, Wallace, Christine, Prine, Merissa, Gregus, Emily, Hare, Jacqueline, Lombardo, Kristen, Fezia, Behashta, Columbus, Teresa, Rushton, Jacob, DuMerton, Deborah, Reid, Ken, Parlow, Joel, Chung, Wiley, Karizhenskaia, Maria, Malik, Aftab, Tanzola, Rob, Giles, Andrew, McLean, Sean R., McGuire, Anna, Lohser, Jens, Lim, Shirley, Grey, Rebecca, Yee, John, Grant, Kyle, Lee, Alex L., Choi, James J., Dewar, Leith R., Durkin, Christopher, Schisler, Travis, Hecht, Patrick, Hughes, Bevan, Kidane, Biniam, Liu, Richard, Tan, Lawrence, Gowing, Stephen, Buduhan, Gordon, Enns, Stephanie, Poole, Emma, Graham, Kristin, Dubik, Niina, Chin, Alex, Maziak, Donna E., Seely, Andrew JE, Gilbert, Sebastien, Villeneuve, P. James, Sundaresan, Sudhir, Gingrich, Molly, Fazekas, Anna, Bucciero, Kirby, Malthaner, Richard A., Lewis, Deb, Fortin, Dalilah, Qiabi, Mehdi, Nayak, Rahul, Plourde, Madelaine Marie, Haider, Tehmina, Murphy, Rowan, Sellers, Daniel, Donahoe, Laura, Lefebvre, Marco, Lanthier, Luc, Ko, Michael Augustine, Parente, David, Cheung, Victoria, Schieman, Colin, Bessissow, Amal, Wong, Randolph HL, Joynt, Gavin M., Lam, Carmen KM, Lau, Rainbow WH, Wan, Innes YP, Underwood, Malcolm J., Wu, William KK, Wong, Wai Tat, Choi, Gordon YS, Lee, Eva, Hui, Ka Yan, Fung, Beaker, Chan, Chee Sam, Ng, Fung Kei, Thung, Kin Hoi, Gutiérrez-Soriano, Laura, Castañeda, Laura Carmenza, Téllez, Luis Jaime, Ortiz-Ramirez, Lina Marcela, Baiardo-Redaelli, Martina, Belletti, Alessandro, Dieci, Elisa, Monaco, Fabrizio, Muriana, Piergiorgio, Nakhnoukh, Cristina, Novellis, Pierluigi, Turi, Stefano, Viscardi, Stefano, Veronesi, Giulia, Voltolini, Luca, Bongiolatti, Stefano, Salvicchi, Alberto, Gatteschi, Lavinia, Indino, Rossella, Tombelli, Simone, Ravasin, Alice, Salimbene, Ottavia, Rosboch, Giulio Luca, Balzani, Eleonora, Ceraolo, Edoardo, Neitzert, Luca, Brazzi, Luca, Londero, Francesco, Grossi, William, Massullo, Domenico, Fiorelli, Silvia, Margaritora, Stefano, Hashim, Shahrul Amry, Krishnasamy, Sivakumar, See, Woan Shiang, Nawaz, Mohammed Asghar, Bilal, Haris, Trujillo Reyes, Juan Carlos, Martínez-Téllez, Elisabeth, Belda Sanchis, Josep, Planas Canovas, Georgina, Libreros Niño, Alejandra, Parera Ruiz, Ana, Cladellas Gutierrez, Esther, Guarino, Mauro, Urrutia Cuchi, Gerard, Argilaga Nogues, Marta, Rovira Juan, Anna, Medina-Aedo, Melixa, Turró Castillejo, Mª Asunción, Gil Sanchez, Josep Mª, Araúz-Sarmiento, Ibell, Herranz Perez, Gracia, Chavarria Murillo, Stephania, Garcia-Osuna, Alvaro, Rodriguez-Arias, Ainhoa, Berga Garrote, Nuria, Martín Grande, Ascension, Parise Roux, Diego, Gajate Martín, Luis, De Pablo Pajares, Angélica, Candela Toha, Angel Manuel, Moreno Mata, Nicolás, Muñoz Molina, Gema, Caballero Silva, Usue, Cabañero, Alberto, Fra Fernandez, Sara, Cavestany García-Matres, Cristina, Simón, Luisa, Montenegro, Cristina, Pozo, Sergio, Gonzàlez-Tallada, Anna, González Suarez, Susana, Ribas Ball, Montserrat, De Nadal Clanchet, Miriam, Pérez Vélez, Javier, Cruz, Patrícia, Sánchez-Pedrosa, Guillermo, Duque, Patricia, González, Guillermo, Huerta, Luis, Rodríguez, Laura, Garutti, Ignacio, Ruiz-Villa, Laura, Martí-Ejarque, Maria del Mar, Gili-Bueno, Mireia, Maddio Vieyra, Ricardo Matias, Fibla, Juan J., Durán, Núria, de Temple Pla, Marina, Rodríguez-Fuster, Alberto, Bermejo-Martínez, Silvia, Carramiñana, Albert, Opitz, Isabelle, Etienne, Harry, Cata, Juan P., Guerra-Londono, Juan Jose, Rajaram, Ravi, Corrales, German, Vaporciyan, Ara, Mehran, Reza, Sepesi, Boris, Walsh, Garrett, Rice, David, Cukierman, Daniel S., Swisher, Stephen, Marchant, Bryan E., Harris, Lynne C., Cusson, Bruce D., Miller, Scott A., Ayad, Sabry, Araujo, Jorge, Marquez-Roa, Leonardo, Hofstra, Richard L., Wudel, Jr., Leonard J., Minear, Steven C., Teixeira, Camila, Pimentel, Mario, Popoff, Andrew M., Marsack, Kelly, Meehan, Sarah, Chen, Tzonghuei H., Essandoh, Michael, Poppers, Jeremy S., Ke Wang, Michael, Chan, Matthew T V, Cata, Juan P, McLean, Sean R, Srinathan, Sadeesh K, Reyes, Juan Carlos Trujillo, Grande, Ascension Martín, Tallada, Anna Gonzalez, Sessler, Daniel I, Maziak, Donna E, McIntyre, William F, Wong, Randolph H L, McGuire, Anna L, Roux, Diego Parise, Wells, Jennifer R, Ofori, Sandra N, Eikelboom, John W, Jolly, Sanjit S, Healey, Jeff S, and Devereaux, P J

Published
2023
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8. IN-HOSPITAL CARDIAC ARRESTS AND THE ROLE OF VASOPRESSIN AND STEROIDS

Author

Farooqui, Arafat, primary, Maheshwari, Sanjay, additional, Uddin, Syed Mohammad Mazhar, additional, Bilal, Haris, additional, Saleem, Naira, additional, Hameed, Samra, additional, Hashmi, Arsalan Talib, additional, Shetty, Vijay, additional, Hollander, Gerald, additional, and Shani, Jacob, additional

Published
2023
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10. Internal Mammary Arteries as a Model to Demonstrate Restoration of the Impaired Vasodilation in Hypertension, Using Liposomal Delivery of the CYP1B1 Inhibitor, 2,3′,4,5′-Tetramethoxystilbene

Author

Zaabalawi, Azziza, primary, Renshall, Lewis, additional, Beards, Frances, additional, Lightfoot, Adam P., additional, Degens, Hans, additional, Alexander, Yvonne, additional, Hasan, Ragheb, additional, Bilal, Haris, additional, Graf, Brigitte A., additional, Harris, Lynda K., additional, and Azzawi, May, additional

Published
2022
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11. Internal Mammary Arteries as a Model to Demonstrate Restoration of the Impaired Vasodilation in Hypertension, Using Liposomal Delivery of the CYP1B1 Inhibitor, 2,3′,4,5′-Tetramethoxystilbene

Author

Zaabalawi, Azziza, Renshall, Lewis, Beards, Frances, Lightfoot, Adam P, Degens, Hans, Alexander, Yvonne, Hasan, Ragheb, Bilal, Haris, Graf, Brigitte A, Harris, Lynda K, Azzawi, May, Zaabalawi, Azziza, Renshall, Lewis, Beards, Frances, Lightfoot, Adam P, Degens, Hans, Alexander, Yvonne, Hasan, Ragheb, Bilal, Haris, Graf, Brigitte A, Harris, Lynda K, and Azzawi, May

Abstract

A significant number of patients with severe cardiovascular disease, undergoing coronary artery bypass grafting (CABG), present with hypertension. While internal mammary arteries (IMAs) may be a better alternative to vein grafts, their impaired vasodilator function affects their patency. Our objectives were to (1) determine if inhibition of the cytochrome P450 enzyme CYP1B1, using liposome-encapsulated 2,3′,4,5′-tetramethoxystilbene (TMS), can potentiate vasodilation of IMAs from CABG patients, and (2) assess mechanisms involved using coronary arteries from normal rats, in an ex vivo model of hypertension. PEGylated liposomes were synthesized and loaded with TMS (mean diameter 141 ± 0.9 nm). Liposomal delivery of TMS improved its bioavailability Compared to TMS solution (0.129 ± 0.02 ng/mL vs. 0.086 ± 0.01 ng/mL at 4 h; p < 0.05). TMS-loaded liposomes alleviated attenuated endothelial-dependent acetylcholine (ACh)-induced dilation in diseased IMAs (@ACh 10−4 M: 56.9 ± 5.1%; n = 8 vs. 12.7 ± 7.8%; n = 6; p < 0.01) for TMS-loaded liposomes vs. blank liposomes, respectively. The alleviation in dilation may be due to the potent inhibition of CYP1B1 by TMS, and subsequent reduction in reactive oxygen species (ROS) moieties and stimulation of nitric oxide synthesis. In isolated rat coronary arteries exposed to a hypertensive environment, TMS-loaded liposomes potentiated nitric oxide and endothelium-derived hyperpolarization pathways via AMPK. Our findings are promising for the future development of TMS-loaded liposomes as a promising therapeutic strategy to enhance TMS bioavailability and potentiate vasodilator function in hypertension, with relevance for early and long-term treatment of CABG patients, via the sustained and localized TMS release within IMAs.

Published
2022

14. Determinants of outcomes following surgery for type A acute aortic dissection: the UK National Adult Cardiac Surgical Audit

Author

Benedetto, Umberto, primary, Dimagli, Arnaldo, additional, Kaura, Amit, additional, Sinha, Shubhra, additional, Mariscalco, Giovanni, additional, Krasopoulos, George, additional, Moorjani, Narain, additional, Field, Mark, additional, Uday, Trivedi, additional, Kendal, Simon, additional, Cooper, Graham, additional, Uppal, Rakesh, additional, Bilal, Haris, additional, Mascaro, Jorge, additional, Goodwin, Andrew, additional, Angelini, Gianni, additional, Tsang, Geoffry, additional, and Akowuah, Enoch, additional

Published
2021
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19. Determinants of outcomes following surgery for type A acute aortic dissection: the UK National Adult Cardiac Surgical Audit.

Author

Benedetto, Umberto, Dimagli, Arnaldo, Kaura, Amit, Sinha, Shubhra, Mariscalco, Giovanni, Krasopoulos, George, Moorjani, Narain, Field, Mark, Uday, Trivedi, Kendal, Simon, Cooper, Graham, Uppal, Rakesh, Bilal, Haris, Mascaro, Jorge, Goodwin, Andrew, Angelini, Gianni, Tsang, Geoffry, and Akowuah, Enoch

Subjects
AORTIC dissection, AORTA surgery, CARDIAC surgery risk factors, SURGICAL complications, MORTALITY -- Mathematical models, STATISTICAL bootstrapping, LOGISTIC regression analysis
Abstract

Aims  Operability of type A acute aortic dissections (TAAAD) is currently based on non-standardized decision-making process, and it lacks a disease-specific risk evaluation model that can predict mortality. We investigated patient, intraoperative data, surgeon, and centre-related variables for patients who underwent TAAAD in the UK. Methods and results We identified 4203 patients undergoing TAAAD surgery in the UK (2009–18), who were enrolled into the UK National Adult Cardiac Surgical Audit dataset. The primary outcome was operative mortality. A multivariable logistic regression analysis was performed with fast backward elimination of variables and the bootstrap-based optimism-correction was adopted to assess model performance. Variation related to hospital or surgeon effects were quantified by a generalized mixed linear model and risk-adjusted funnel plots by displaying the individual standardized mortality ratio against expected deaths. Final variables retained in the model were: age [odds ratio (OR) 1.02, 95% confidence interval (CI) 1.02–1.03; P  < 0.001]; malperfusion (OR 1.79, 95% CI 1.51–2.12; P  < 0.001); left ventricular ejection fraction (moderate: OR 1.40, 95% CI 1.14–1.71; P  = 0.001; poor: OR 2.83, 95% CI 1.90–4.21; P  < 0.001); previous cardiac surgery (OR 2.29, 95% CI 1.71–3.07; P  < 0.001); preoperative mechanical ventilation (OR 2.76, 95% CI 2.00–3.80; P  < 0.001); preoperative resuscitation (OR 3.36, 95% CI 1.14–9.87; P  = 0.028); and concomitant coronary artery bypass grafting (OR 2.29, 95% CI 1.86–2.83; P  < 0.001). We found a significant inverse relationship between surgeons but not centre annual volume with outcomes. Conclusions  Patient characteristics, intraoperative factors, cardiac centre, and high-volume surgeons are strong determinants of outcomes following TAAAD surgery. These findings may help refining clinical decision-making, supporting patient counselling and be used by policy makers for quality assurance and service provision improvement. [ABSTRACT FROM AUTHOR]

Published
2022
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20. Additional file 1: of Exceptional response to chemotherapy followed by concurrent radiotherapy and immunotherapy in a male with primary retroperitoneal serous Adenocarcinoma: a case report and literature review

Author

Chae, Young, Saleem, Naira, Yoonhwan Roh, Bilal, Haris, Viveiros, Pedro, Bhoomika Sukhadia, Xiaoqi Lin, Sheikh, Muhammad, and Park, Lee

Abstract

Figure S1. Tumor response map illustrating more than 50% decrease in somatic alteration burden following chemotherapy. (DOCX 61 kb)

Published
2019
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22. EMERGENCY ABDOMINAL SURGERY;

Author

SULTAN, JUNAID, primary, BILAL, HARIS BIN, additional, KIRAN, HUMAIRA, additional, Bilal, Badar Bin, additional, and Yusuf, Azam, additional

Published
2019
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27. Is stereotactic ablative radiotherapy equivalent to sublobar resection in high-risk surgical patients with Stage I non-small-cell lung cancer?

Author

Mahmood, Sarah, Bilal, Haris, Faivre-Finn, Corinne, and Shah, Rajesh

Subjects
Lung Neoplasms, Carcinoma, Non-Small-Cell Lung, Humans, Best Evidence Topics, Pneumonectomy, Radiosurgery
Abstract

A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was ‘Is stereotactic ablative radiotherapy equivalent to sublobar resection in high-risk surgical patients with Stage I non-small cell lung cancer?’. Altogether over 318 papers were found, of which 18 represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. Stereotactic ablative radiotherapy (SABR) and sublobar resection (SLR) offer clear survival benefit in the treatment of early-stage non-small-cell lung cancer (NSCLC) in high-risk patients unsuitable for lobectomy and SABR has shown good results in medically operable patients. No randomized data are available comparing SLR and SABR, and therefore, data from prospective studies were compared. Overall survival at 1 year was similar between patients treated with SABR and SLR (81–85.7 vs 92%); however, overall 3-year survival was higher following SLR (87.1 vs 45.1–57.1%). There was no statistically significant difference in local recurrence in patients treated with SABR compared with SLR (3.5–14.5 vs 4.8–20%). Both treatment modalities are associated with complications. Fatigue (31–32.6%), pneumonitis (2.1–12.5%) and chest wall pain (3.1–12%) were common following SABR; however, serious grade 3 and 4 toxicity were rare. Morbidity following SLR was reported between 7.3 and 33.7%. Thirty-day mortality following SABR was 0%, while predicted 30-day mortality following a lung resection, using the thoracoscore predictive model ranges between 1 and 2.6%. Treatment for early-stage NSCLC should be tailored to individual patients. SABR is an acceptable alternative to SLR in high-risk patients but comparative data are required.

Published
2013

42. Physio-chemical Distinctiveness and Metroglyph Analysis of Cotton Genotypes at Early Growth Stage under Saline Hydroponics.

Author

Aslam, Muhammad, Basra, Shahzad M.A., Maqbool, Muhammad Amir, Bilal, Haris, Zaman, Qamar U., and Bano, Saira

Subjects
*HYDROPONICS, *PLANT growth, *SALINE solutions, *PLANT physiology, *PLANT genetics, COTTON genetics
Abstract

A hydroponic study was carried out to determine the response of 13 cotton (Gossypium hirsutum L.) genotypes at three salinity levels viz, 0.8, 8 and 16 dS m-1 for various physiological and biochemical traits. Data were subjected to metroglyph analyses for the estimation of genetic diversity under contrasting salinity regimes. The genotypes were grouped into five clusters with maximum index score of 97 per cluster. Minimum index score of 13 in case of cluster-V under non saline regime was observed. Three clusters were constructed with range of index scores from 119 to 23 at 8 dS m-1, while all genotypes were grouped into five clusters with maximum and minimum index scores 114 and 23 in cluster-I and cluster-IV, respectively at 16 dS m-1. Relative salinity tolerance was also observed among genotypes at two saline regimes. NIAB-111 and Russian (RL) were the most susceptible and SLH-41 and UCD-581 were found the most tolerant at 8 dS m-1, whereas at 16 dS m-1 NIAB-111 and MS-39 were proved most susceptible and Groog-25, FH-982, TX-DOS-5-76C and Russian okra (RL) as most tolerant. We conclude that genotypes belonging to different clusters show diversity in salinity tolerance and can be used for further breeding programs with focus on development of salinity tolerant germplasm on the basis of easily detectable physiological and biochemical criteria. [ABSTRACT FROM AUTHOR]

Published
2013

43. Valve-Sparing Aortic Root Repair Compared to Composite Aortic Root Replacement: A Systematic Review and Meta-Analysis.

Author

Harky A, Fok M, Froghi S, Bilal H, and Bashir M

Subjects
Cardiopulmonary Bypass, Hospital Mortality, Humans, Operative Time, Reoperation statistics & numerical data, Aortic Aneurysm surgery, Heart Valve Prosthesis Implantation
Abstract

Background: Aortic root aneurysms represent a significant risk of morbidity and mortality. Composite root replacement is the preferred practice for repair, although recently valve-sparing replacement has become a popular alternative. The study aim was to identify comparative studies that simultaneously analyzed composite root and valve-sparing root replacement outcomes., Methods: A systematic review of the current literature was performed through four major databases, from inception until 2016. All comparative studies of valve-sparing versus composite root replacement were identified. All studies were assessed by two reviewers for their applicability and inclusion., Results: A total of 12 comparative papers was identified encompassing 2,352 patients (700 valve-sparing and 1,652 composite); the mean follow up was 3.7 ± 1.7 years. Aortic cross-clamp and cardiopulmonary bypass times were lower in the composite group (p <0.0001 and p<0.00001, respectively). In-hospital mortality was low, but higher in the composite group (p = 0.002). Only one study reported long-term follow up. In studies reporting reoperation, there was slight difference favoring composite over valve-sparing replacement (p = 0.05)., Conclusions: Valve-sparing and composite root replacement remain feasible options for replacement of the aortic root. Long-term data of comparative studies are not yet available to assess the viability of these procedures.

Published
2017

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