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The safety and reliability of inverters play a significant role in stable power electronic system operations. Considering a railway vehicle air-conditioning inverter as a case study, this paper presents a generic open-circuit fault diagnosis method that can be applied to various inverter and control schemes. First, a detailed model of three-phase output currents under both normal and fault status is derived, and then the concept of space trajectory is introduced based on the three-phase output currents. The open-circuit faults of the inverter lead to output phase current distortion. Therefore, different types of faults have different space trajectories, and the corresponding shape of the space trajectory is considered to be a fault feature. Then, the fault is located by the direction vector and center-of-mass coordinate. The effectiveness and reliability of the diagnosis method are verified and analyzed using a hardware-in-the-loop test platform. [ABSTRACT FROM AUTHOR]