565 results on '"Bil P"'
Search Results
2. ERASE: a feasible early warning tool for elder abuse, developed for use in the Dutch emergency department
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van Houten, Miriam E., Vloet, Lilian C. M., Rikkert, Marcel G. M. Olde, van de Kerkhof-van Bon, Brigitte, de Rooij, Anneriek, Verhoeven, Marieke, Bil, Wilhelmina M. E., Lucke, Jacinta A., Schoon, Yvonne, and Berben, Sivera A. A.
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- 2024
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3. The use of aesthetic medicine in the treatment of rosacea
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Aleksandra Latała, Marcin Wąs, Natalia Zozula, Zuzanna Tomczewska, Aleksandra Rykucka, Justyna Kiełbasa, Agata Kowalczyk, Katarzyna Bil, Iga Ślesicka, Magda Przestrzelska, and Natalia Winiarska
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Botulinum toxin ,rosacea ,erythema ,laser therapy ,Sports ,GV557-1198.995 ,Sports medicine ,RC1200-1245 - Abstract
Introduction and purpose: Rosacea is a chronic inflammatory dermatosis. It mainly affects the central parts of the face and manifests itself with redness, erythema, telangiectasia, and papulopustular lesions. The aim of the work is to review current rosacea therapy techniques, detailing aesthetic medicine treatments. Material and methods: In order to create the review, the PubMed and Scopus databases were searched in April and May 2024. The searches took place between April 24 and May 15, 2024 and consisted of a critical analysis of the acquired sources of knowledge. State of knowledge: The introduction of lasers to the market has revolutionized the therapy of rosacea and appropriately selected parameters and patient qualification for the treatment ensure therapeutic success. Botulinum toxin is a potent neurotoxin that blocks the release of acetylcholine from the presynaptic vesicle. Appropriate home care is an extremely important factor in maintaining the disease in the remission phase. Conclusion Among the possibilities of aesthetic medicine, rosacea therapy is definitely dominated by laser therapy. There are several lasers available on the market today, the most commonly used of which is IPL. Ablative lasers are used to treat a deformed nose caused by rhinophyma. Botulinum toxin is administered as an intradermal injection, thanks to which it reduces erythema and redness of the skin. After appropriate treatment by a dermatologist and aesthetic medicine doctor, well-selected home care plays a key role in maintaining the disease in the remission phase.
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- 2024
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4. The role of vitamin D in multiple sclerosis and its mechanisms of action
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Agata Kowalczyk, Justyna Kiełbasa, Magda Przestrzelska, Aleksandra Rykucka, Marcin Wąs, Natalia Zozula, Zuzanna Tomczewska, Katarzyna Bil, Iga Ślesicka, and Aleksandra Latała
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vitamin D ,multiple sclerosis ,neuroprotection ,neurodegeneration ,Sports ,GV557-1198.995 ,Sports medicine ,RC1200-1245 - Abstract
Introduction and Purpose: Multiple sclerosis (MS) is a prevalent autoimmune disease affecting the central nervous system, particularly in young people. Characterized by neurodegenerative and demyelinating processes, MS is influenced by genetic and environmental factors. Research indicates that sufficient levels of vitamin D can reduce the risk of developing MS. Studies show that higher sun exposure and dietary vitamin D intake are associated with a lower incidence of MS. Moreover, vitamin D supplementation may benefit those already diagnosed by alleviating symptoms and improving their quality of life. This review explores the potential benefits of vitamin D and its neuroprotective mechanisms in MS. State of Knowledge: MS research and treatments have focused on immunomodulation, with less emphasis on neuroprotection, including the role of vitamin D. It is well-established that vitamin D has anti-inflammatory effects on the immune system in MS. It influences the proliferation and differentiation of neural stem cells and oligodendrocytes, enhances neurotrophin expression, reduces reactive astrogliosis, decreases oxidative stress, and stabilizes the blood-brain barrier. Research suggests that adequate vitamin D levels and supplementation might improve MS outcomes. Conclusion: New diagnostic tools and therapeutic strategies are urgently needed to address the complex nature of MS, which includes inflammation, neuronal death, demyelination, and oxidative stress. Promoting vitamin D sufficiency and supplementation, alongside developing new neuroprotective agents, remains a valuable approach in combating MS. Understanding the mechanisms of MS and the effects of vitamin D could lead to better management strategies and enhanced quality of life for patients.
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- 2024
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5. Chronic Fatigue Syndrome: Insights and Treatment Perspectives – a literature review
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Iga Ślesicka, Magda Przestrzelska, Natalia Zozula, Zuzanna Tomczewska, Aleksandra Rykucka, Marcin Wąs, Aleksandra Latała, Justyna Kiełbasa, Agata Kowalczyk, and Katarzyna Bil
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CFS ,Neuroimmune Disorders ,Chronić Fatigue Syndrome ,Myalgic Encephalomyelitis ,Malaise ,Sports ,GV557-1198.995 ,Sports medicine ,RC1200-1245 - Abstract
Introduction: Chronic Fatigue Syndrome (CFS) is an exhausting continuous medical condition. In most cases it affects patients after a flu-like infection. CFS correlates with alterations in the nervous and immune systems, metabolism, and hormone secretion. Diagnostic process is very challenging due to the absence of a definitive diagnostic test and wide symptomatology. It negatively impacts people's both mental and physical health. Aim of the study: The aim of this literature review is to comprehensively examine current research findings and literature on Chronic Fatigue Syndrome (CFS), understand its etiology, how it affects the body, why it's challenging to diagnose, the various treatments available, new ideas and viewpoints in the field. Describing the State of Knowledge: Despite extensive investigation, the exact etiology of CFS remains unknown. In literature CFS is also often described as Myalgic Encephalomyelitis. In the WHO's most recent classification, the ICD-11, both Chronic Fatigue Syndrome and Myalgic Encephalomyelitis are classified as “other disorders of the nervous system” which indicates the significance of the issue. Conclusions: This literature review underlines the importance of a comprehensive and collaborative approach in addressing the complexities of CFS and improving outcomes for individuals living with this debilitating condition.
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- 2024
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6. Hydrogen breath test as a diagnostic tool
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Natalia Zozula, Zuzanna Tomczewska, Aleksandra Rykucka, Marcin Wąs, Aleksandra Latała, Justyna Kiełbasa, Agata Kowalczyk, Katarzyna Bil, Iga Ślesicka, and Magda Przestrzelska
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Hydrogen breath test ,Carbohydrate malabsorption ,Lactose malabsorption ,Fructose malabsorption ,SIBO ,Sports ,GV557-1198.995 ,Sports medicine ,RC1200-1245 - Abstract
Introduction and Purpose: Hydrogen breath tests serve the crucial purpose of evaluating the absorption of nutrients in the small intestine, particularly when carbohydrates are not properly absorbed, leading to bacterial overgrowth. These tests are non-invasive, cost-effective, and widely accessible diagnostic tools used to assess various gastrointestinal disorders. The objective of this review is to evaluate the effectiveness and methodology of Hydrogen breath testing (HBT). State of knowledge: The disposal of hydrogen gas is essential for maintaining efficient microbial fermentation processes in the gut. Hydrogenotrophic microbes, including acetogens, methanogenic archaea, and sulfate-reducing bacteria, are responsible for this process. Hydrogen breath tests, conducted with substrates like glucose and lactulose, aid in diagnosing conditions such as small intestinal bacterial overgrowth (SIBO), lactose and fructose intolerance, and other carbohydrate absorption disorders. These tests generate a large volume of data, which can be analyzed using data mining techniques to uncover new hypotheses. Conclusions: Hydrogen breath tests, using various substrates, are effective in diagnosing gastrointestinal disorders such as SIBO and carbohydrate malabsorption. They offer valuable insights into microbial processes in the gut and can inform individualized treatment strategies. However, careful consideration of contraindications and proper test administration protocols is essential for accurate diagnosis and interpretation of results.
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- 2024
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7. Risk assessment of preeclampsia
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Zuzanna Tomczewska, Aleksandra Rykucka, Natalia Zozula, Marcin Wąs, Justyna Kiełbasa, Agata Kowalczyk, Katarzyna Bil, Iga Ślesicka, Aleksandra Latała, and Magda Przestrzelska
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preeclapsia ,sFlt-1/PlGF ratio ,biomarkers ,hypertension ,aspirin ,Sports ,GV557-1198.995 ,Sports medicine ,RC1200-1245 - Abstract
Introduction and purpose: Preeclampsia (PE) is a complication during pregnancy characterized by high blood pressure (≥140/90 mmHg) and signs of organ involvement appearing after 20 weeks’ of gestation. Various factors are known to increase the risk of this condition as well as clinical factors. The pathogenesis of the disease is complex and not fully understood. State of Knowledge: The main roles play two angiogenic factors: soluble fms-like tyrosine kinase 1 (sFlt-1), which is an antiangiogenic protein, and placental growth factor (PlGF), which is a pro-angiogenic protein. Elevated sFlt-1 and reduced PlGF levels in the mother’s blood can predict the future development of preeclampsia during pregnancy. The imbalance between these two angiogenic biomarkers indicates de new-onset preeclampsia, distinct from chronic hypertension. Both MAP and UTA-PI are essential components of first-trimester screening protocols, which, combined with maternal history and other biochemical markers, allow for accurate preeclampsia risk assessment and early intervention to improve maternal and fetal outcomes. Conclusions: Preeclampsia is a major cause of maternal and perinatal morbidity and mortality. The integration of multiple biomarkers, such as PlGF and sFlt-1, along with advanced analytical techniques, enhances early detection and accurate risk stratification, improving maternal and fetal outcomes. Aspirin prophylaxis before 16 weeks’ gestation has been shown to reduce the risk of preeclampsia.
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- 2024
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8. ERASE: a feasible early warning tool for elder abuse, developed for use in the Dutch emergency department
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Miriam E. van Houten, Lilian C. M. Vloet, Marcel G. M. Olde Rikkert, Brigitte van de Kerkhof-van Bon, Anneriek de Rooij, Marieke Verhoeven, Wilhelmina M. E. Bil, Jacinta A. Lucke, Yvonne Schoon, and Sivera A. A. Berben
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Elder abuse ,Warning tool ,Feasibility ,Emergency department ,Special situations and conditions ,RC952-1245 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Background Elder abuse is a worldwide problem with serious consequences for individuals and society. To effectively deal with elder abuse, a timely identification of signals as well as a systematic approach towards (suspected) elder abuse is necessary. This study aimed to develop and test the acceptability and appropriateness of ERASE (EldeR AbuSE) in the emergency department (ED) setting. ERASE is an early warning tool for elder abuse self-administered by the healthcare professional in patients ≥ 70 years. Methods A systematic literature review was previously conducted to identify potential available instruments on elder abuse for use in the ED. Furthermore, a field consultation in Dutch hospitals was performed to identify practice tools and potential questions on the recognition of elder abuse that were available in clinical practice. Based on this input, in three subsequent rounds the ERASE tool was developed. The ERASE tool was tested in a pilot feasibility study in healthcare professionals (n = 28) working in the ED in three Dutch hospitals. A semi-structured online questionnaire was used to determine acceptability and appropriateness of the ERASE tool. Results The systematic literature review revealed seven screening instruments developed for use in the hospital and/or ED setting. In total n = 32 (44%) hospitals responded to the field search. No suitable and validated instruments for the detection of elder abuse in the ED were identified. The ERASE tool was developed, with a gut feeling awareness question, that encompassed all forms of elder abuse as starting question. Subsequently six signalling questions were developed to collect information on observed signs and symptoms of elder abuse and neglect. The pilot study showed that the ERASE tool raised the recognition of healthcare professionals for elder abuse. The tool was evaluated acceptable and appropriate for use in the ED setting. Conclusions ERASE as early warning tool is guided by an initial gut feeling awareness question and six signalling questions. The ERASE tool raised the recognition of healthcare professionals for elder abuse, and was feasible to use in the ED setting. The next step will be to investigate the reliability and validity of the ERASE early warning tool.
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- 2024
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9. Description of COVID-19 Vaccination Behavior in Rural and Urban Communities in Serang District
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Febriyeni Fitria, Raihana Nadra Alkaff, Dela Aristi, Aike Wella Bil Bariyah, Ainur Rosyidah, and Reni Ridatus Salamah
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Medicine ,Public aspects of medicine ,RA1-1270 - Abstract
Public health status in Indonesia can be influenced by the implementation of healthy behavior in the community. There are differences in behavior between people in rural and urban areas and factors that can cause vaccine delays that have the potential to affect COVID-19 vaccination coverage in Indonesia. This study aims to determine the behavior of COVID-19 vaccination in rural and urban communities in Serang Regency. This study used a descriptive research design with a quantitative approach which was conducted in October−November 2021 with a sample of 334 people aged 18−59 years. The results showed that the vaccination status of the respondents was complete dose (rural 65.3% and urban 70.3%), waiting for dose 2 (rural 22.4% and urban 18.6%), and dose 1 had been received but the dosing schedule 2 had passed (rural 12.3% and urban 11.1%). Three perceptions that are still low in percentage are perceptions of vulnerability, perceptions of obstacles, and cues to act. Some of the reasons for stopping the termination of COVID-19 in the community are not yet feeling that they will have severe symptoms if exposed to COVID-19, feeling confused about information related to COVID-19, not being able to carry out COVID-19 vaccinations because the schedule for COVID-19 vaccination program coincides with other activities, did not receive an invitation from the local government to vaccinate against COVID-19, vaccinate because people in their environment had vaccinated against COVID-19, did not receive support from cadres or religious leaders for the COVID-19 vaccination. Improved policy behavior can be improved by changing perceptions of vulnerability to COVID-19, reducing barriers, and also providing cues according to education through social media with the key message of spending the full dose of vaccine.
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- 2024
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10. The treatment of chronic wounds using bacteriophages
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Katarzyna Bil, Justyna Kiełbasa, Agata Kowalczyk, Natalia Zozula, Aleksandra Latała, Iga Ślesicka, Aleksandra Rykucka, Marcin Wąs, Magda Przestrzelska, and Zuzanna Tomczewska
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chronic wound ,chronic wounds infection ,biofilms ,MDR ,bacteriophage ,phage therapy ,Education ,Sports ,GV557-1198.995 ,Medicine - Abstract
Introduction and aim of study: Chronic wounds are increasingly challenging global healthcare. These wounds, which take over 3 months to heal, are complicated by untreated infections and the formation of biofilm, hindering healing and antibiotic effectiveness. To tackle these issues, new treatments like bacteriophage therapy are being explored. Bacteriophages, viruses that target bacteria, offer promise in overcoming antibiotic resistance. However, their use presents challenges that need to be addressed. Material and methods: Our review is based on the analysis of materials collected in Pubmed, Elsevier and other scientific articles using keywords: “chronic wound”, “chronic wounds infection”, “biofilms”, “MDR”, “bacteriophage”, “phage therapy”. Conclusions: The rise of chronic wounds due to resistant infections poses a significant challenge for patients and healthcare systems. Multidrug-resistant bacteria, often forming biofilm, evade current treatments, urging the search for alternatives. Phage therapy, showing efficacy against various stubborn infections, including those from surgery or diabetes, gains attention. Advanced delivery systems enhance targeted treatment, while phage cocktails improve effectiveness, especially against multiple resistant strains. Safety is generally observed, but larger trials are needed. Though not a replacement for antibiotics, phage therapy offers hope, needing robust clinical validation. While challenges exist, its societal, commercial, and economic benefits suggest a promising future beyond clinical use.
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- 2024
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11. Searching for the Holy Grail among ear drops
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Justyna Kiełbasa, Katarzyna Bil, Agata Kowalczyk, Natalia Zozula, Aleksandra Latała, Iga Ślesicka, Aleksandra Rykucka, Marcin Wąs, Magda Przestrzelska, and Zuzanna Tomczewska
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cerumen ,hygiene ,cerumenolytic agents ,Education ,Sports ,GV557-1198.995 ,Medicine - Abstract
Introduction and aim of the study: Ear wax plays many roles in maintaining ear health, such as cleansing, shielding, and lubricating the external auditory canal. Sometimes, when earwax obstruction occurs, for example as a result of improper hygiene procedures (such as using cotton swabs), it can cause a number of disorders ranging from discomfort to even loss of hearing. In such cases, various methods can be used to remove the cerumen impaction. One of these and also the most commonly used, involves the usage of ear drops, which can contain different active substances (water-based compounds, oil-based compounds, a combination of oil and water-based compounds, and non-water, non-oil solutions). The aim of our study is to present current state of knowledge about effectiveness of various types of ear drops in wax cleaning. Material and methods: Our review is based on the analysis of materials collected in Pubmed”, „Google Scholar” and other scientific articles using keywords: „earwax”, cerumen impaction”, „cerumenolytics”, „ear drops”, „cerumen”, „earwax solvents”, „wax solvents”. Conclusions: Despite numerous studies, the Holy Grail has not been found among ear drops. The majority conducted studies did not show that any of the cerumenolitics were superior to the others in a statistically significant way. The only result that was statistically significant was the one showing a higher effectiveness of 2.5% sodium bicarbonate compared to docusate sodium. Further research is needed.
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- 2024
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12. Exploring the efficacy of cannabinoids in the management of multiple sclerosis
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Aleksandra Rykucka, Natalia Zozula, Marcin Wąs, Justyna Kiełbasa, Agata Kowalczyk, Katarzyna Bil, Iga Ślesicka, Aleksandra Latała, Zuzanna Tomczewska, and Magda Przestrzelska
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multiple sclerosis ,Cannabis ,cannabinoids ,neuropathic pain ,spasticity ,therapeutic strategies ,Education ,Sports ,GV557-1198.995 ,Medicine - Abstract
Introduction: Multiple Sclerosis (MS) is a chronic autoimmune disease of the central nervous system, marked by inflammation, demyelination, and neurodegeneration. It severely impacts quality of life with symptoms like spasticity, pain, and cognitive impairment. Conventional treatments often fail, necessitating alternative therapies. Purpose: This review evaluates the efficacy and safety of cannabis extracts in treating MS, enhancing understanding of their benefits and limitations. State of knowledge: Studies suggest that cannabinoids may alleviate MS symptoms, particularly spasticity and pain. Clinical trials have shown significant reductions in muscle stiffness and pain, along with improved sleep quality. Meta-analyses, by Whiting et al. and Cochrane, support these findings but highlight the risk of side effects, which may limit long-term use. Additionally, research on animal models and in vitro studies indicate that cannabinoids may have neuroprotective and immunomodulatory properties, potentially reducing neuroinflammation and demyelination. Conclusion: Cannabinoids exhibit potential as a complementary therapy for managing MS symptoms, especially spasticity and pain. However, evidence is mixed, with some studies showing limited efficacy and considerable risk of side effects. More long-term, high-quality studies are needed to fully understand the therapeutic potential and safety profile of cannabinoids in MS treatment. Despite the challenges, the growing availability and changing legal status of medical cannabis suggest it could be a viable option for some patients, provided its use is carefully monitored and adapted to individual needs.
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- 2024
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13. Treatment Methods for Varicose Veins of the Lower Limbs
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Marcin Wąs, Aleksandra Latała, Natalia Zozula, Aleksandra Rykucka, Justyna Kiełbasa, Agata Kowalczyk, Katarzyna Bil, Iga Ślesicka, Zuzanna Tomczewska, and Magda Przestrzelska
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Varicose veins ,Chronic venous insufficiency ,Hemodynamic abnormalities ,Genetic predisposition ,Minimally invasive therapies ,Compression therapy ,Education ,Sports ,GV557-1198.995 ,Medicine - Abstract
Introduction and Purpose: Varicose veins in the lower limbs are common, particularly among those with prolonged standing occupations, contributing to chronic venous insufficiency (CVI). CVI affects about 60% of adults, with varicose veins present in 25–33% of women and 10–20% of men, increasing with age. Understanding and addressing this condition is crucial as it impacts daily life and raises the risk of thrombosis. Effective treatments are essential to alleviate these health issues. State of Knowledge: Varicose veins result from a mix of genetic, hemodynamic, and vein wall factors. Family history plays a significant role, increasing susceptibility. Hemodynamic issues include malfunctioning venous valves and elevated venous pressure. Vein wall changes and thrombotic activity also contribute. Symptoms range from cosmetic concerns to pain and complications like venous ulcers. Understanding these factors is key for effective management. Conclusions: Surgical treatments like high ligation and stripping are standard but have drawbacks such as scarring and long recovery. Valvuloplasty addresses deep venous valve issues but is limited. Minimally invasive options, such as endovenous laser therapy and sclerotherapy, offer promising alternatives but with some recurrence risk. Compression therapies, including elastic stockings and pneumatic compression, aid recovery and symptom relief. Elastic bandage therapy is effective but requires precise application to avoid complications. Each method has pros and cons, underscoring the need for tailored treatment approaches.
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- 2024
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14. Subjective Norms of Health Students Related to Parent's Social Control on Intention to Stop Smoking
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Ahsanu Bil Husna, Ira Nurmala, Erdi Istiaji, and Erwin Nur Rif'ah
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adolescent ,intention to stop smoking ,parents’ opinion ,social control ,Public aspects of medicine ,RA1-1270 - Abstract
Smoking among students is a significant global issue. Health students, expected to be knowledgeable about smoking dangers and serve as role models, are found to engage in smoking behavior, which is concerning. This study aimed to analyze health students' perceptions regarding parental social control and their intention to quit smoking using the Theory of Planned Behaviour, specifically focusing on the role of subjective norms. The study used a descriptive qualitative approach with a phenomenological methodology involving in-depth interviews and observations. The research was conducted in Jember Regency with five primary informants, health students at the University of Jember, and key informants who were close friends and parents of primary informants. Data processing used the interactive data analysis model proposed by Miles and Huberman, involving three steps: data reduction, data presentation, and conclusion drawing. The study found that health students who smoke positively perceived their parents' opinions and social support regarding smoking cessation behavior. They viewed their parents' efforts to prevent them from smoking as beneficial and effective in influencing their behavior. health students who smoke acknowledged that the social control exerted by their parents was crucial in helping them overcome their smoking habits. Most health students who smoke expressed a strong intention to quit smoking, indicating a willingness to change their behavior in response to the support they received from their parents. The study suggests that parents should set a good example and communicate effectively to influence adolescent smoking behavior. Health students and health offices can also support this effort through smoking cessation activities and education.
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- 2024
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15. Correction: Intentional coronary revascularization versus conservative therapy in patients after peripheral artery revascularization due to critical limb ischemia: the INCORPORATE trial
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Toth, Gabor G, Brodmann, Marianne, Schnur, Sadeek S Kanoun, Bartus, Stanislaw, Vrsalovic, Mislav, Krestianinov, Oleg, Kala, Petr, Bil, Jacek, Gil, Robert, Kanovsky, Jan, Di Serafino, Luigi, Paolucci, Luca, Barbato, Emanuele, Mangiacapra, Fabio, and Ruzsa, Zoltan
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- 2024
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16. Development of Emotional Competence in Exam Situations with Students Who Achieve Different Academic Success and Study Different Study Programs
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Pavlovic, Zlatko, Kaurin, Sonja, and Sladoje-Bošnjak, Bil?ana
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The authors, in the theoretical part of the paper, define and explain the concept of emotional competence, as well as skills that should be developed and strengthened within the mentioned concept. Also, the importance of emotional competence in exam situations for the academic success of students has been presented, which is supported by the presentation of research related to this topic. The aim of the study was to examine whether students with different academic achievement and from different study programs showed different levels of emotional competence in exam situations. The research was conducted on a sample of 115 students from the Faculty of Philosophy, University of East Sarajevo. The paper presents the results of examining the differences in the development of emotional competence in exam situations in students with different academic achievement and the results of examining the differences in the development of emotional competence in students in exam situations depending on the study program they study. The findings show that there are no differences in the development of emotional competence in exam situations in students with different academic achievement, but there are differences when it comes to the development of emotional competence in exam situations depending on the study program that students' study. This research is a contribution to a better understanding of students' emotional competencies in exam situations and may have practical implications in terms of understanding the importance of improving the emotional sphere in all study programs by expanding study objectives so that they include developing of students' emotional competencies.
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- 2021
17. THE EFFICIENCY OF IMMUNE MODULATOR BIVEL IN THE PREVENTION OF PULMONARY TUBERCULOSIS IN EXPOSED CHILDREN FROM THE MULTIDRUG-RESISTANT TUBERCULOSIS SITES
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Olha SAKHELASHVILI-BIL and Iryna PLATONOVA
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bivel immunomodulator ,pulmonary tuberculosis in children ,cellular immunity ,tuberculosis ,Medicine (General) ,R5-920 ,Internal medicine ,RC31-1245 ,Other systems of medicine ,RZ201-999 ,Public aspects of medicine ,RA1-1270 - Abstract
120 exposed children/adolescents (75 children and 45 adolescents) from the multi-drug resistant tuberculosis sites underwent the complex clinical radiological and immunological examination.Insignificant functional disorders of cellular response (immunoregulatory processes) caused by the prevalence of suppressor and cytotoxic reactions by 1.3 times and by the prevalence of pro-inflammatory cytokines in the regulatory system (2.0 times above the norm, TNF-α/IL 10.0. р
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- 2024
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18. Segmenting, Targeting, and Positioning Strategies in Attracting the Interest of Students in Learning Nahwu
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Umar Manshur, Hasan Baharun, Dakir Dakir, and Zadana Bil Mahasini
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nahwu science ,segmenting ,targeting and positioning ,interest to learn ,Language and Literature - Abstract
This research aims to analyze Segmenting, Targeting, and Positioning (STP) strategies to attract the interest of students studying Nahwu at the Nurul Jadid Islamic Boarding School, Probolinggo, East Java, Indonesia. This research uses a qualitative approach with a case study type of research. Researchers conducted observations, in-depth interviews, and documentation to obtain accurate, valid, and accountable data. Data analysis was carried out systemically, starting from data reduction, data presentation, and drawing research conclusions. This research shows that segmenting, targeting, and positioning, mapping, and placing students in learning Nahwu science is very important so that learning can provide comfortable and meaningful conditions for students; this can increase students' interest in studying Nahwu science. This research provides implications regarding the importance of appropriate segmentation, targeting, and positioning in learning Nahwu science so that educational institutions can increase students' interest in learning and involvement in studying Nahwu science more effectively, excitingly, and meaningfully so that learning objectives can be achieved maximally.
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- 2023
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19. The effectiveness of gratitude intervention in reducing negative emotions in sexual abuse victims
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Hamka Hamka, Mein-Woei Suen, Nisa Rachmah Nur Anganthi, Aniq Hudiyah Bil Haq, and Bayu Prasetyo
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gratitude intervention ,negative emotion ,sexual abuse ,Psychology ,BF1-990 - Abstract
Gratitude therapy is a positive psychotherapy approach given to victims of sexual abuse to generate positive thinking by expressing gratitude to the environment, God and other people. This research aims to test gratitude intervention as a religious activity undertaken to reduce negative emotions in victims of sexual abuse. A total of 104 such victims were identified using the snowball sampling method who were divided into an experimental group (N=52) and a control group (N=52). They were diagnosed as having negative emotions based on the child Trauma Questionnaire Shot-Focus (CTQ-SF) and Gratitude Questioner-6 (GQ-6) with triple ANOVA data analysis. The study’s results demonstrate a significant influence of gratitude on negative emotion, with values of F(39,037) = 4.71, p .01, and ηp2 = 0.113. It can increase feelings of gratitude and reduce negative emotions in victims of sexual abuse. Gratitude therapy helps reduce negative emotions and foster positive emotions amongst such victims. The study could be implemented in people who experience negative emotions related to clinical and non-clinical disorders.
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- 2023
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20. Klotho inhibits IGF1R/PI3K/AKT signalling pathway and protects the heart from oxidative stress during ischemia/reperfusion injury
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Agnieszka Olejnik, Anna Radajewska, Anna Krzywonos-Zawadzka, and Iwona Bil-Lula
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Medicine ,Science - Abstract
Abstract Ischemia/reperfusion injury (IRI) of the heart involves the activation of oxidative and proapoptotic pathways. Simultaneously Klotho protein presents anti-aging, antiapoptotic and antioxidative properties. Therefore, this study aimed to evaluate the effect of Klotho protein on oxidative stress in hearts subjected to IRI. Isolated rat hearts perfused with the Langendorff method were subjected to ischemia, followed by reperfusion, in the presence or absence of recombinant rat Klotho protein. The factors involved in the activation of insulin-like growth factor receptor (IGF1R)/phosphoinositide-3-kinase (PI3K)/protein kinase B (AKT) signalling pathway were evaluated. IRI caused activation of the IGF1R (p = 0.0122)/PI3K (p = 0.0022) signalling, as compared to the aerobic control group. Infusion supply of Klotho protein during IRI significantly reduced the level of phospho-IGF1R (p = 0.0436), PI3K (p = 0.0218) and phospho-AKT (p = 0.0020). Transcriptional activity of forkhead box protein O3 (FOXO3) was reduced (p = 0.0207) in hearts subjected to IRI, compared to aerobic control. Administration of Klotho decreased phosphorylation of FOXO3 (p = 0.0355), and enhanced activity of glutathione peroxidase (p = 0.0452) and superoxide dismutase (p = 0.0060) in IRI + Klotho group. The levels of reactive oxygen/nitrogen species (ROS/RNS) (p = 0.0480) and hydrogen peroxide (H2O2) (p = 0.0460), and heart injury (p = 0.0005) were significantly increased in hearts from the IRI group in comparison to the aerobic group. Klotho reduced NADPH oxidase 2 (NOX2) (p = 0.0390), ROS/RNS (p = 0.0435) and H2O2 (p = 0.0392) levels, and heart damage (p = 0.0286) in the hearts subjected to IRI. In conclusion, Klotho contributed to the protection of the heart against IRI and oxidative stress via inhibition of the IGF1R/PI3K/AKT pathway, thus can be recognized as a novel cardiopreventive/cardioprotective agent.
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- 2023
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21. miRNAs in Signal Transduction of SMAD Proteins in Breast Cancer
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Tomasz Sirek, Agata Sirek, Przemysław Borawski, Nikola Zmarzły, Joanna Sułkowska, Katarzyna Król-Jatręga, Marcin Opławski, Dariusz Boroń, Michał Chalcarz, Piotr Ossowski, Konrad Dziobek, Damian Strojny, Kacper Boroń, Dominika Janiszewska-Bil, and Beniamin Oskar Grabarek
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breast cancer ,miRNA ,SMAD ,transforming growth factor beta ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
The aim of this study was to identify miRNAs that could potentially influence the activity of SMAD proteins involved in TGFβ signal transduction in five types of breast cancer in Polish women. Patients with five breast cancer subtypes were included in the study: luminal A (n = 130), luminal B HER2− (n = 100), luminal B HER2+ (n = 96), non-luminal HER2+ (n = 36), and TNBC (n = 43). During surgery, tumor tissue was removed along with a margin of healthy tissue (control). Molecular analysis included determination of the expression of genes related to SMAD protein signal transduction using mRNA microarrays and reverse transcription quantitative polymerase chain reaction (RT-qPCR). Protein expression was determined using an enzyme-linked immunosorbent assay (ELISA). The miRNA profiling was performed using miRNA microarrays and the miRDB database. SMAD3 and SMAD5 were overexpressed in all types of breast cancer, which could be related to the reduced expression of miR-145, and the findings for SMAD4 and miR-155 were similar. Additionally, the level of SMAD7 was reduced, which may be due to the low activity of miR-15b and miR21b. This study determined the gene expression profiles involved in SMAD protein signal transduction across five different types of breast cancer and identified the miRNAs potentially regulating their activity. Overexpression of SMAD3, SMAD4, and SMAD5 suggests excessive activation of the TGFβ pathway, potentially promoting tumor growth and development. Concurrently, a significant reduction in SMAD7 expression removes inhibitory control in the TGFβ pathway, a phenomenon that is particularly evident in more aggressive breast cancer types.
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- 2024
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22. Klotho inhibits IGF1R/PI3K/AKT signalling pathway and protects the heart from oxidative stress during ischemia/reperfusion injury
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Olejnik, Agnieszka, Radajewska, Anna, Krzywonos-Zawadzka, Anna, and Bil-Lula, Iwona
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- 2023
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23. Consideration of pathways for immunotoxicity of per- and polyfluoroalkyl substances (PFAS)
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Ehrlich, Veronika, Bil, Wieneke, Vandebriel, Rob, Granum, Berit, Luijten, Mirjam, Lindeman, Birgitte, Grandjean, Philippe, Kaiser, Andreas-Marius, Hauzenberger, Ingrid, Hartmann, Christina, Gundacker, Claudia, and Uhl, Maria
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- 2023
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24. Peran Rasa Syukur dalam Pengendalian Kecemasan dan Stress pada Mahasiswa
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Aniq Hudiyah Bil Haq, Hamka, Alfiza Fakhria Haq, Muslimin Nulipata, Aulia Ramdani, Desita Dyah Damayanti, and Mein-Woei Suen
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rasa syukur ,mahasiswa ,stres ,gratitude ,anxiety ,Islam ,BP1-253 - Abstract
Anxiety and stress can have a psychological effect on the student learning process. Students need to reduce anxiety and stress with positive emotions such as gratitude. The purpose of this research is to determine the effect of gratitude on anxiety and stress in students. Quantitative methods were used in this research by taking samples through r simple random sampling. The sample in this study was students in the city of Samarinda, with data collected using the gratitude questionnaire (GQ-6) and Depression, Anxiety and stress Scale (DASS-21). This research uses multiple linear regression statistical analysis. The results of this study found that there was a significant influence regarding gratitude on anxiety and stress among students in the city of Samarinda. With a high sense of gratitude, students can reduce anxiety and stress so that students' lives become calmer, more prosperous and happier
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- 2024
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25. Capacidad exportadora de la industria argentina durante el siglo XXI. Breve revisión de casos para un diagnóstico
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Damián Bil
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Exportaciones ,Industria ,Argentina ,Mercados ,historia económica ,Business ,HF5001-6182 ,Economic history and conditions ,HC10-1085 ,Economics as a science ,HB71-74 - Abstract
Desde la crisis de 2008, las exportaciones de contenido tecnológico de la Argentina pierden mercados. Con menor capacidad de apropiar riqueza a nivel mundial, su economía sufre un achicamiento que deriva en devaluación, inflación, empeoramiento de las condiciones de vida, etc. Proponemos analizar, en términos cuantitativos, la evolución reciente del comercio exterior argentino, atendiendo a la dinámica de exportaciones industriales de relevante contenido tecnológico. Tomamos casos testigos, revisando su evolución, mercados principales y efectos de la expansión china como nuevo proveedor de los socios tradicionales de la Argentina. El objetivo es dilucidar la trayectoria de exportaciones claves en la estructura productiva argentina y pensar, a futuro, un diagnóstico que permita sugerir líneas de acción para relanzar la capacidad exportadora.
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- 2024
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26. Strengths, weaknesses, opportunities and threats of peer support among disadvantaged groups: A rapid scoping review
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Kalina Mikolajczak-Degrauwe, Sybren R. Slimmen, Dylan Gillissen, Petra de Bil, Valerie Bosmans, Corrine Keemink, Inge Meyvis, and Yvonne J. Kuipers
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Peer support ,Scoping review ,Sociological factors ,Vulnerable populations ,Nursing ,RT1-120 - Abstract
Objective: To explore the current state of knowledge and evidence about peer support for various disadvantaged groups; to identify the strengths, weaknesses, opportunities, and threats of peer support to critically reflect on peer support within health and social services. Methods: A rapid scoping review was conducted according to Arksey and O’Malley’s framework, aiming to identify eligible studies in PubMed, APA PsychInfo, Education Resources Information Center, Cochrane Library, Academic Search Premier, ScienceDirect, Directory of Open Access Journals, ResearchGate, WorldCat, and Google Scholar. According to Rodgers’ concept analysis steps and the SWOT model, data was reported using thematic synthesis. Results: Forty-five studies were included, describing a variety of peer support initiatives among groups of young migrants and unsupervised minors, young adults with autism, people with (mental) health problems, foster/shelter families, vulnerable pregnant women, people outside the labour force, older adults, and homeless people. The strength of peer support is its positive effect on the quality of life among vulnerable people. The weakness is represented by peers both being too involved and focused on personal interest or by peers lacking expertise and knowledge. Opportunities for peer support are mutual learning, the anticipated long-term effects, and the potential to facilitate social inclusion. Culture, language barriers, drop-out rates, securing sustainability, and peers’ lack of time and commitment are regarded as threats to peer support. Conclusion: Although peer support offers good outcomes for various groups of vulnerable people, the weaknesses and threats need to be considered to provide and proliferate peer support.
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- 2023
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27. Evaluation of the effectiveness of immunomodulator BI-V in the complex therapy of children and adolescents with multiple drug-resistant pulmonary tuberculosis
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O.I. Sakhelashvili-Bil and I.L. Platonova
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multiple drug-resistant pulmonary tuberculosis ,treatment ,bedaquiline ,delamanid ,bi-v ,children ,adolescents ,Therapeutics. Pharmacology ,RM1-950 - Abstract
BACKGROUND. The feasibility of combining antimycobacterial therapy (AMBT) with bedaquiline (Bdq) and delamanid (Dlm) with non-specific immunomodulator BI-V in children and adolescents with multidrug-resistant and rifampicin-resistant pulmonary tuberculosis (MDR/Rif-TBP) needs to be studied. OBJECTIVE. To find out the effectiveness of the use of complex AMBT with Bdq and Dlm with non-specific immunomodulator BI-V in children and adolescents with MDR/Rif-TBP. MATERIALS AND METHODS. Children and adolescents with MDR/Rif-TBP at the initial stage of AMBT were given BI-V (BIVEL, Slovenia) as a non-specific immunomodulator. The patients were divided into two groups: 1st – 20 patients who received Bdq + Dlm + levofloxacin (Lfx) + linezolid (Lzd) + clofazimine (Cfz); 2nd ‒ 28 patients whose complex treatment included BI-V (Вdq + Dlm + Lfx + Lzd + Cfz + BI-V). BI-V was prescribed from the age of 3 years at 5 ml suspension once a day during 24 days RESULTS. The use of BI-V against the background of individualized regimens of AMBT in children and adolescents with MDR/Rif-TBP increased the effectiveness of treatment, contributed to the disappearance of symptoms of intoxication, the resolution of infiltration foci and the healing of decay cavities in system of immune protection, which contributed to the shortening of the inpatient stage of treatment, while maintaining a high therapeutic effectiveness (“cured” ‒ 92.8 %) and the formation of small residual changes in the lungs in the majority (89.3 %). CONCLUSIONS. When using combined complex AMBT with Bdq, Dlm and BI-V, high therapeutic efficiency was observed in most patients (92.8 %).
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- 2023
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28. The Effect of the Process Parameters on the Growth Rate and Composition of the Anti Scratch Films Deposited from TEOS by AP-PECVD on Polycarbonate
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Bil, Anastasia S. and Alexandrov, Sergey E.
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- 2023
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29. Drug-Eluting Balloons and Drug-Eluting Stents in Diabetic Patients Undergoing Percutaneous Coronary Intervention Due to Restenosis—DM-Dragon Registry
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Piotr Niezgoda, Michał Kasprzak, Jacek Kubica, Łukasz Kuźma, Rafał Januszek, Sylwia Iwańczyk, Brunon Tomasiewicz, Jacek Bil, Mariusz Kowalewski, Miłosz Jaguszewski, Maciej Wybraniec, Krzysztof Reczuch, Sławomir Dobrzycki, Stanisław Bartuś, Maciej Lesiak, Mariusz Gąsior, Rafał Wolny, Adam Witkowski, Robert Gil, Bernardo Cortese, Fabrizio D’Ascenzo, Wojciech Wojakowski, and Wojciech Wańha
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DEB ,DES ,restenosis ,diabetes mellitus ,in-stent restenosis (ISR) ,Medicine - Abstract
Background: The rate of in-stent restenosis (ISR) is decreasing; however, it is still a challenge for contemporary invasive cardiologists. Therapeutic methods, including drug-eluting balloons (DEBs), intravascular lithotripsy, excimer laser coronary atherectomy, and imaging-guided percutaneous coronary intervention (PCI) with drug-eluting stents (DES), have been implemented. Patients with diabetes mellitus (DM) are burdened with a higher risk of ISR than the general population. Aims: DM-Dragon is aimed at evaluating the clinical outcomes of ISR treatment with DEBs vs. DES, focusing on patients with co-existing diabetes mellitus. Methods: The DM-Dragon registry is a retrospective study comprising data from nine high-volume PCI centers in Poland. A total of 1117 patients, of whom 473 individuals had DM and were treated with PCI due to ISR, were included. After propensity-score matching (PSM), 198 pairs were created for further analysis. The primary outcome of the study was target lesion revascularization (TLR). Results: In DM patients after PSM, TLR occurred in 21 (10.61%) vs. 20 (10.1%) in non-diabetic patients, p = 0.8690. Rates of target vessel revascularization (TVR), target vessel myocardial infarction, device-oriented composite endpoint (DOCE), and cardiac death did not differ significantly. Among diabetic patients, the risk of all-cause mortality was significantly lower in the DEB group (2.78% vs. 11.11%, HR 3.67 (95% confidence interval, CI) [1.01–13.3), p = 0.0483). Conclusions: PCI with DEBs is almost as effective as DES implantation in DM patients treated for ISR. In DM-Dragon, the rate of all-cause death was significantly lower in patients treated with DEBs. Further large-scale, randomized clinical trials would be needed to support these findings.
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- 2024
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30. The Kinetics of Inflammation-Related Proteins and Cytokines in Children Undergoing CAR-T Cell Therapy—Are They Biomarkers of Therapy-Related Toxicities?
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Paweł Marschollek, Karolina Liszka, Monika Mielcarek-Siedziuk, Iwona Dachowska-Kałwak, Natalia Haze, Anna Panasiuk, Igor Olejnik, Tomasz Jarmoliński, Jowita Frączkiewicz, Zuzanna Gamrot, Anna Radajewska, Iwona Bil-Lula, and Krzysztof Kałwak
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chimeric antigen receptors ,CAR-T cells ,CRS ,ICANS ,cytokines ,biomarkers ,Biology (General) ,QH301-705.5 - Abstract
CD19-targeted CAR-T cell therapy has revolutionized the treatment of relapsed/refractory (r/r) pre-B acute lymphoblastic leukemia (ALL). However, it can be associated with acute toxicities related to immune activation, particularly cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). Cytokines released from activated immune cells play a key role in their pathophysiology. This study was a prospective analysis of proinflammatory proteins and cytokines in children treated with tisagenlecleucel. Serial measurements of C-reactive protein, fibrinogen, ferritin, IL-6, IL-8, IL-10, IFNγ, and TNFα were taken before treatment and on consecutive days after infusion. The incidence of CRS was 77.8%, and the incidence of ICANS was 11.1%. No CRS of grade ≥ 3 was observed. All complications occurred within 14 days following infusion. Higher biomarker concentrations were found in children with CRS grade ≥ 2. Their levels were correlated with disease burden and CAR-T cell dose. While cytokine release syndrome was common, most cases were mild, primarily due to low disease burden before lymphodepleting chemotherapy (LDC). ICANS occurred less frequently but exhibited various clinical courses. None of the toxicities were fatal. All of the analyzed biomarkers rose within 14 days after CAR-T infusion, with most reaching their maximum around the third day following the procedure.
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- 2024
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31. Ten-Year Outcomes in Patients Undergoing Simultaneous Coronary and Renal Angiography—Does Renal Artery Stenosis Matter?
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Adam Kern, Tomasz Stompór, Krystian Bojko, Ewa Sienkiewicz, Sebastian Pawlak, Dariusz Pawlak, Grzegorz Poskrobko, Ewa Andrasz, Leszek Gromadziński, Rakesh Jalali, Dariusz Onichimowski, Grażyna Piwko, Artur Zalewski, and Jacek Bil
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atherosclerosis ,renal artery disease ,invasive angiography ,long-term outcomes ,Medicine - Abstract
Background: We aimed to characterize the population of consecutive patients undergoing coronary angiography with simultaneous renal artery angiography and assess prognostic factors at a 10 year follow-up. Methods: The KORONEF study was a prospective, single-center, observational, and descriptive study with 492 patients included. We analyzed several baseline demographics, clinical and periprocedural characteristics, and laboratory data, and we assessed the results of coronary angiography and renal artery angiography. Results: The study population consisted of 37.2% women, and the mean age was 64.4 ± 9.9 years (min. 30 years, max. 89 years). Angiography revealed significant renal artery stenosis (RAS) in 35 (7.1%) patients. Among patients with significant RAS (≥50%), we observed more women (57.1% vs. 35.7%, p = 0.011), and patients were older (69.1 ± 10.4 years vs. 64.0 ± 9.7 years, p = 0.005). In the whole population, all-cause death was reported in 29.9% of patients, myocardial infarction (MI) rate—in 11.8%, and stroke—in 4.9%. In the multivariable analysis, independent predictors of death were age 65–75 years (HR 2.88), age > 75 years (HR 8.07), diabetes (HR 1.59), previous MI (HR 1.64), chronic kidney disease (HR 2.22), unstable angina (HR 0.37), and left ventricular ejection fraction > 60% (HR 0.43). Conclusions: Over a 10 year follow-up, the all-cause death rate was 29.9%, showing no statistically significant differences between patients with and without significant RAS.
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- 2024
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32. Percutaneous Coronary Interventions with Sirolimus-Eluting Alex Plus Stents in Patients with or without Diabetes: 4-Year Results
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Jacek Bil, Maciej Tyczynski, Adam Kern, Krystian Bojko, and Robert J. Gil
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SES ,PCI ,Alex Plus ,target lesion revascularization ,in-stent restenosis ,thin-strut stent ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
We characterized the performance, as well as the safety, of a second-generation thin-strut sirolimus-eluting stent with a biodegradable polymer, Alex Plus (Balton, Poland), implanted in patients with type 2 diabetes (DM) with a 4-year follow-up. We defined the primary endpoint as the 48-month rate of major cardiovascular adverse events (MACE), including cardiac death, myocardial infarction (MI), or target lesion revascularization (TLR). The secondary endpoints were all-cause death, cardiac death, MI, and TLR rates at 12, 24, 36, and 48 months. We enrolled 232 patients in whom 282 stents were implanted, including 97 DM and 135 non-DM patients. The mean age of the DM patients was 69.5 ± 10.1 years and females accounted for 30% of the patients. DM patients had higher rates of arterial hypertension (97% vs. 88%, p = 0.016), dyslipidemia (86% vs. 70%, p = 0.005), prior MI (61% vs. 40%, p = 0.002), prior PCI (65% vs. 50%, p = 0.020), and prior CABG (14% vs. 5.9%, p = 0.029). We recorded statistically significant differences for MACE (HR 1.85, 95% CI 1.01–3.41, p = 0.046), cardiac death (HR 4.46, 95% CI 1.44–13.8, p = 0.010), and MI (HR 3.17, 95% CI 1.10–9.12, p = 0.033), but not for TLR, between DM and non-DM patients in terms of the analyzed endpoints at 4 years. Our study showed that Alex Plus was efficient and safe in a contemporary cohort of real-world DM patients undergoing percutaneous revascularization.
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- 2024
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33. Observation of a sudden cessation of a very-high-energy gamma-ray flare in PKS 1510-089 with H.E.S.S. and MAGIC in May 2016
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Collaboration, H. E. S. S., Abdalla, H., Adam, R., Aharonian, F., Benkhali, F. Ait, Angüner, E. O., Arcaro, C., Arm, C., Armstrong, T., Ashkar, H., Backes, M., Baghmanyan, V., Martins, V. Barbosa, Barnacka, A., Barnard, M., Becherini, Y., Berge, D., Bernlöhr, K., Bi, B., Böttcher, M., Boisson, C., Bolmont, J., Bonnefoy, S., de Lavergne, M. de Bony, Bregeon, J., Breuhaus, M., Brun, F., Brun, P., Bryan, M., Büchele, M., Bulik, T., Bylund, T., Caroff, S., Carosi, A., Casanova, S., Ch, T., Ch, S., Chen, A., Cotter, G., Curyło, M., Mbarubucyeye, J. Damascene, Davids, I. D., Davies, J., Deil, C., Devin, J., deWilt, P., Dirson, L., Djannati-Ataï, A., Dmytriiev, A., Donath, A., Doroshenko, V., Dyks, J., Egberts, K., Eichhorn, F., Einecke, S., Emery, G., Ernenwein, J. -P., Feijen, K., Fegan, S., Fiasson, A., de Clairfontaine, G. Fichet, Filipovic, M., Fontaine, G., Funk, S., Füßling, M., Gabici, S., Gallant, Y. A., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Gottschall, D., Grondin, M. -H., Hahn, J., Haupt, M., Hermann, G., Hinton, J. A., Hofmann, W., Hoischen, C., Holch, T. L., Holler, M., Hörbe, M., Horns, D., Huber, D., Jamrozy, M., Jankowsky, D., Jankowsky, F., Jardin-Blicq, A., Joshi, V., Jung-Richardt, I., Kastendieck, M. A., Katarzyński, K., Katz, U., Khangulyan, D., Khélifi, B., Klepser, S., Kluźniak, W., Komin, Nu., Konno, R., Kosack, K., Kostunin, D., Kreter, M., Lamanna, G., Lemière, A., Lemoine-Goumard, M., Lenain, J. -P., Levy, C., Lohse, T., Lypova, I., Mackey, J., Majumdar, J., Malyshev, D., Mar, V., Marchegiani, P., Marcowith, A., Mares, A., Martí-Devesa, G., Marx, R., Maurin, G., Meintjes, P. J., Meyer, M., Mitchell, A. M. W., Moderski, R., Mohamed, M., Mohrmann, L., Montanari, A., Moore, C., Morris, P., Moulin, E., Muller, J., Murach, T., Nakashima, K., Nayerhoda, A., de Naurois, M., Ndiyavala, H., Niederwanger, F., Niemiec, J., Oakes, L., O'Brien, P., Odaka, H., Ohm, S., Olivera-Nieto, L., Wilhelmi, E. de Ona, Ostrowski, M., Panter, M., Panny, S., Parsons, R. D., Peron, G., Peyaud, B., Piel, Q., Pita, S., Poireau, V., Noel, A. Priyana, Prokhorov, D. A., Prokoph, H., Pühlhofer, G., Punch, M., Quirrenbach, A., Raab, S., Rauth, R., Reichherzer, P., Reimer, A., Reimer, O., Remy, Q., Renaud, M., Rieger, F., Rinchiuso, L., Romoli, C., Rowell, G., Rudak, B., Ruiz-Velasco, E., Sahakian, V., Sailer, S., Sanchez, D. A., Santangelo, A., Sasaki, M., Scalici, M., Schüssler, F., Schutte, H. M., Schwanke, U., Schwemmer, S., Seglar-Arroyo, M., Senniappan, M., Seyffert, A. S., Shafi, N., Shiningayamwe, K., Simoni, R., Sinha, A., Sol, H., Specovius, A., Spencer, S., Spir-Jacob, M., Stawarz, Ł., Sun, L., Steenkamp, R., Stegmann, C., Steinmassl, S., Steppa, C., Takahashi, T., Tavernier, T., Taylor, A. M., Terrier, R., Tiziani, D., Tluczykont, M., Tomankova, L., Trichard, C., Tsirou, M., Tuffs, R., Uchiyama, Y., van der Walt, D. J., van Eldik, C., van Rensburg, C., van Soelen, B., Vasileiadis, G., Veh, J., Venter, C., Vincent, P., Vink, J., Völk, H. J., Vuillaume, T., Wadiasingh, Z., Wagner, S. J., Watson, J., Werner, F., White, R., Wierzcholska, A., Wong, Yu Wun, Yusafzai, A., Zacharias, M., Zanin, R., Zargaryan, D., Zdziarski, A. A., Zech, A., Zhu, S. J., Zorn, J., Zouari, S., Żywucka, N., Collaboration, MAGIC, Acciari, V. A., Ansoldi, S., Antonelli, L. A., Engels, A. Arbet, Asano, K., Baack, D., Babić, A., Baquero, A., de Almeida, U. Barres, Barrio, J. A., González, J. Becerra, Bednarek, W., Bellizzi, L., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Bil, A., Blanch, O., Bonnoli, G., Bošnjak, Ž., Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colin, U., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Amico, G., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Depaoli, D., Di Pierro, F., Di Venere, L., neira, E. Do Souto Espi\, Prester, D. Dominis, Donini, A., Dorner, D., Doro, M., Elsaesser, D., Ramazani, V. Fallah, Fattorini, A., Ferrara, G., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., López, R. J. García, Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Green, D., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., Hütten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jouvin, L., Kajiwara, Y., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., López, M., López-Coto, R., López-Oramas, A., Loporchio, S., Fraga, B. Machado de Oliveira, Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Mender, S., Mićanović, S., Miceli, D., Miener, T., Minev, M., Mir, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletić, L., nil, P. Pe\, Perennes, C., Persic, M., Moroni, P. G. Prada, Pr, E., Priyadarshi, C., Puljak, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Spolon, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Surić, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Torres-Albà, N., Tosti, L., Truzzi, S., van Scherpenberg, J., Vanzo, G., Acosta, M. Vazquez, Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Zarić, D., Jorstad, S. G., Marscher, A. P., Boccardi, B., Casadio, C., Hodgson, J., Kim, J. -Y., Krichbaum, T. P., Lähteenmäki, A., Tornikoski, M., Traianou, E., and Weaver, Z. R.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Astrophysics of Galaxies - Abstract
The flat spectrum radio quasar (FSRQ) PKS 1510-089 is known for its complex multiwavelength behavior, and is one of only a few FSRQs detected at very high energy (VHE, $E>100\,$GeV) $\gamma$-rays. VHE $\gamma$-ray observations with H.E.S.S. and MAGIC during late May and early June 2016 resulted in the detection of an unprecedented flare, which reveals for the first time VHE $\gamma$-ray intranight variability in this source. While a common variability timescale of $1.5\,$hr is found, there is a significant deviation near the end of the flare with a timescale of $\sim 20\,$min marking the cessation of the event. The peak flux is nearly two orders of magnitude above the low-level emission. For the first time, curvature is detected in the VHE $\gamma$-ray spectrum of PKS 1510-089, which is fully explained through absorption by the extragalactic background light. Optical R-band observations with ATOM reveal a counterpart of the $\gamma$-ray flare, even though the detailed flux evolution differs from the VHE ightcurve. Interestingly, a steep flux decrease is observed at the same time as the cessation of the VHE flare. In the high energy (HE, $E>100\,$MeV) $\gamma$-ray band only a moderate flux increase is observed with Fermi-LAT, while the HE $\gamma$-ray spectrum significantly hardens up to a photon index of 1.6. A search for broad-line region (BLR) absorption features in the $\gamma$-ray spectrum indicates that the emission region is located outside of the BLR. Radio VLBI observations reveal a fast moving knot interacting with a standing jet feature around the time of the flare. As the standing feature is located $\sim 50\,$pc from the black hole, the emission region of the flare may have been located at a significant distance from the black hole. If this correlation is indeed true, VHE $\gamma$ rays have been produced far down the jet where turbulent plasma crosses a standing shock., Comment: 25 pages, 17 figures. Accepted for publication by Astronomy & Astrophysics. Corresponding authors: M. Zacharias, J. Sitarek, D. Sanchez, T. Terzic
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- 2020
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34. Impact of microbiological characteristics on the costs of treating diabetic foot infection
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Batista, Julianne Soares Jardim Lacerda, Bassetti, Bil Randerson, Kaiser, Thaís Dias Lemos, Vicente, Creuza Rachel, and Schuenck, Ricardo Pinto
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- 2023
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35. Sub-continental-scale carbon stocks of individual trees in African drylands
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Tucker, Compton, Brandt, Martin, Hiernaux, Pierre, Kariryaa, Ankit, Rasmussen, Kjeld, Small, Jennifer, Igel, Christian, Reiner, Florian, Melocik, Katherine, Meyer, Jesse, Sinno, Scott, Romero, Eric, Glennie, Erin, Fitts, Yasmin, Morin, August, Pinzon, Jorge, McClain, Devin, Morin, Paul, Porter, Claire, Loeffler, Shane, Kergoat, Laurent, Issoufou, Bil-Assanou, Savadogo, Patrice, Wigneron, Jean-Pierre, Poulter, Benjamin, Ciais, Philippe, Kaufmann, Robert, Myneni, Ranga, Saatchi, Sassan, and Fensholt, Rasmus
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- 2023
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36. Assessment of the Effectiveness of Glaucoma Treatment Using MicroPulse Transscleral Cyclophotocoagulation in Patients with Glaucoma Who Have Previously Undergone Vitreoretinal Surgery
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Kuciel-Polczak, Izabela, Helemejko, Maciej, Dobrowolski, Dariusz, Janiszewska-Bil, Dominika, Krysik, Katarzyna, Grabarek, Beniamin Oskar, and Lyssek-Boroń, Anita
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- 2023
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37. Speech Features in Food Endorsement of Indonesian Influencers: a Study of Language and Gender
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Assayyidah Bil Ichromatil Ilmi and Sailal Arimi
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feminine speech features ,food promotion ,language and gender ,masculine speech features ,instagram ,Language and Literature - Abstract
This study aims to identify the speech features employed by male and female influencers while promoting food. This research decided to apply a qualitative method, specifically in the form of a case study. Meanwhile, the researchers chose observation through social media, namely Instagram, as the data collection process. The data analysis consists of three stages, such as reduction, presentation, and conclusion. The researchers found that the female influencers use speech features are intensifier, emphatic stress, tag question, rising intonation, empty adjectives, specialized, hypercorrect grammar, super polite forms, avoidance of strong swear, and one form that belongs to the men known as command and directive. Meanwhile, the speech features employed by the men are command and directive, swearing and taboo words, compliments, and theme, and three forms of speech feature that belong to women, which are intensifier, empty adjective, and emphatic stress. The finding of this study is that both genders are not constantly with their own speech features. Both genders also applied speech features that belong to the opposite gender while doing promotion, although the language features of each gender dominate the respective results. Abstrak Penelitian ini bertujuan mengidentifikasi fitur tuturan yang digunakan oleh influencer pria dan wanita saat melakukan promosi makanan. Penelitian ini menggunakan metode kualitatif, khususnya dalam bentuk studi kasus. Penulis memilih observasi melalui salah satu media sosial, yakni Instagram, pada proses pengumpulan data. Proses analisis data terdiri atas tiga tahap, yaitu reduksi, penyajian, dan penarikan simpulan. Penulis menemukan bahwa para influencer wanita menggunakan fitur ucapan yang intensif, penekanan tegas, tanda pertanyaan, intonasi tinggi, kata sifat kosong, kata khusus, tata bahasa yang berlebihan, bentuk sangat sopan, menghindari umpatan yang kuat, dan satu bentuk milik pria yang dikenal sebagai perintah dan direktif. Sementara itu, ciri-ciri tuturan yang digunakan oleh influencer laki-laki adalah tuturan perintah dan direktif, umpatan dan kata-kata tabu, pujian, dan tema, serta tiga bentuk tuturan yang dimiliki wanita, yaitu intensifier, kata sifat kosong, dan tekanan empatik. Temuan dari penelitian ini adalah bahwa kedua jenis influencer tidak selalu memiliki fitur bicara mereka sendiri. Mereka juga menerapkan fitur bicara milik lawan jenis saat melakukan promosi meskipun hasilnya didominasi oleh ciri fitur bahasa pada masing-masing gender.
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- 2023
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38. Correction: Exploring factors influencing patient mortality and loss to follow-up in two paediatric hospital wards in Zamfara, North-West Nigeria, 2016-2018.
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Anna Maisa, Abdulhakeem Mohammed Lawal, Tarikul Islam, Chijioke Nwankwo, Bukola Oluyide, Adolphe Fotso, Harriet Roggeveen, Saskia van der Kam, Cono Ariti, Karla Bil, and Annick Lenglet
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Medicine ,Science - Abstract
[This corrects the article DOI: 10.1371/journal.pone.0262073.].
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- 2024
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39. Correction: Neonatal blood lead concentration predicts medium term lead-related outcomes in children ≤5 years old with congenital lead poisoning: A retrospective cohort study in Northern Nigeria.
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Natalie Thurtle, Katharine A Kirby, Jane Greig, Karla Bil, Paul I Dargan, Godwin N Ntadom, and Nicholas A Buckley
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Public aspects of medicine ,RA1-1270 - Abstract
[This corrects the article DOI: 10.1371/journal.pgph.0001644.].
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- 2024
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40. The effect of gonadoliberin analog treatment in precocious puberty on polycystic ovarian syndrome prevalence in adulthood
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Dominika Orszulak, Kacper Niziński, Adriana Bil, Aneta Gawlik, Katarzyna Ziora, and Agnieszka Drosdzol-Cop
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central precocious puberty ,polycystic ovary syndrome ,premature thelarche ,gonadotropin releasing hormone analogues ,early puberty ,Rotterdam criteria ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Precocious puberty is diagnosed when pubertal characteristics appear before the age of 8 years in females. The most common form is gonadotropin-dependent, called axial. The primary method of treatment is administration of gonadotrophin-releasing hormone analogues (GnRHa). The aim of the study was to verify hypothesis that GnRHa therapy in the childhood may be of additive risk factor for polycystic ovary syndrome (PCOS) in adulthood.Material and MethodsThe study group consists of 24 women (median age 22 88 years, median BMI 23.5) treated with GnRHa for central precocious puberty in childhood. The control group includes 40 women (median age 23 years, median BMI 25.6) diagnosed with isolated premature thelarche and not using GnRHa in the childhood. Anthropometric measurements, ultrasound examination of minor pelvis and hormonal profile were performed. PCOS diagnosis was based on Rotterdam criteria.ResultsThe study confirmed a higher prevalence of PCOS in the study group (50%) than in the control group (10%); p=0.0006. Significant, linear correlation between free testosterone levels and ovarian size was found in the study group (R=0.45 p= 0.03).ConclusionsGnRHa therapy during childhood may have a potential influence on incidence of PCOS in the adulthood. Therefore, in this group of patients long-term follow-up focused on screening for PCOS would seem beneficial.
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- 2024
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41. Redox imbalance in patients with heart failure and ICD/CRT-D intervention. Can it be an underappreciated and overlooked arrhythmogenic factor? A first preliminary clinical study
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Jakub Szyller, Radosław Antoniak, Katarzyna Wadowska, Iwona Bil-Lula, Bruno Hrymniak, Waldemar Banasiak, and Dariusz Jagielski
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oxidative stress ,redox imbalance ,ventricular arrhythmia ,implantable cardioverter-defibrillator ,cardiac resynchronization therapy ,heart failure ,Physiology ,QP1-981 - Abstract
Introduction: Redox imbalance and oxidative stress are involved in the pathogenesis of arrhythmias. They also play a significant role in pathogenesis of heart failure (HF). In patients with HFand implanted cardioverter-defibrillator (ICD) or cardiac resynchronization therapy defibrillator (CRT-D), the direct current shocks may be responsible for additional redox disturbances and additionally increase arrhythmia risk. However, the precise role of oxidative stress in potentially fatal arrhythmias and shock induction remains unclear.Methods: 36 patients with diagnosed HF and implanted ICD/CRT-D were included in this study. Patients were qualified to the study group in case of registered ventricular arrhythmia and adequate ICD/CRT-D intervention. The control group consisted of patients without arrhythmia with elective replacement indicator (ERI) status. Activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH) in erythrocyte (RBC), SOD, GPx activity and reactive oxygen/nitrogen species (ROS/RNS) concentration in plasma were determined. The values were correlated with glucose, TSH, uric acid, Mg and ion concentrations.Results: In the perishock period, we found a significant decrease in RBC and extracellular (EC) SOD and RBC CAT activity (p = 0.0110, p = 0.0055 and p = 0.0002, respectively). EC GPx activity was also lower (p = 0.0313). In all patients, a decrease in the concentration of all forms of glutathione was observed compared to the ERI group. Important association between ROS/RNS and GSH, Mg, TSH and uric acid was shown. A relationship between the activity of GSH and antioxidant enzymes was found. Furthermore, an association between oxidative stress and ionic imbalance has also been demonstrated. The patients had an unchanged de Haan antioxidant ratio and glutathione redox potential.Conclusion: Here we show significant redox disturbances in patients with HF and ICD/CRT-D interventions. Oxidative stress may be an additional risk factor for the development of arrhythmia in patients with HF. The detailed role of oxidative stress in ventricular arrhythmias requires further research already undertaken by our team.
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- 2023
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42. Evaluation of the effectiveness of bedaquiline and delamanid treatment among children and adolescents with multi-drug-resistant pulmonary tuberculosis
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M.I. Sakhelashvili, I.L. Platonova, O.I. Sakhelashvili-Bil, and Z.I. Piskur
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children ,tuberculosis ,adolescents ,multidrug resistance ,extensive drug resistance ,treatment ,bedaquiline ,delamanid ,Pediatrics ,RJ1-570 - Abstract
Introduction. Against the backdrop of multiple and widespread drug resistance of Mycobacterium tuberculosis (MDR-TB), there has been a significant decline in the effectiveness of treatment of tuberculosis (TB) patients in Ukraine and globally. Therefore, in recent years, new antimycobacterial drugs, such as bedaquiline (Bdq), delamanid (Dlm) and pretomanid, have been introduced to improve treatment efficacy in adults, children and adolescents. The purpose - to study the effectiveness of complex treatment with bedaquiline (Bdq) and delamanid (Dlm) in children under 18 years old with multiple and extensively drug-resistant pulmonary TB (MDR/XDR-TB). Materials and methods. To study the clinical efficacy of chemotherapy with Bdq and Dlm, a retrospective cohort analysis of medical records was conducted. The main group consisted of 40 children with MDR/XDR-TB who received comprehensive antimycobacterial therapy with Bdq and Dlm; and the control group consisted of 27 patients who received treatment without Bdq and Dlm. Results. It was found that during the first three months of treatment, there was a decrease in bacilli in all patients treated with Bdq and Dlm and in the group of patients without these new drugs (control), but in the control group, the decrease was significantly slower, p
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- 2023
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43. Consideration of pathways for immunotoxicity of per- and polyfluoroalkyl substances (PFAS)
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Veronika Ehrlich, Wieneke Bil, Rob Vandebriel, Berit Granum, Mirjam Luijten, Birgitte Lindeman, Philippe Grandjean, Andreas-Marius Kaiser, Ingrid Hauzenberger, Christina Hartmann, Claudia Gundacker, and Maria Uhl
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Per- and polyfluoroalkyl substances ,Immune function ,Immunotoxicity ,Molecular mechanisms ,Vaccination response ,HBM4EU ,Industrial medicine. Industrial hygiene ,RC963-969 ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Per- and polyfluoroalkyl substances (PFAS) are of public health concern, because of their ubiquitous and extremely persistent occurrence, and depending on their structure, their bio-accumulative, mobile and toxic properties. Human health effects associated with exposure to PFAS include adverse effects on the immune system. In 2020, EFSA (the European Food Safety Authority) defined adverse effects on the immune system as the most critical effect for human health risk assessment, based on reduced antibody responses to childhood vaccines and similar effects observed in experimental animal studies. Likewise, the U.S. EPA (Environmental Protection Agency) considers PFAS-induced immunotoxicity, especially in children, as the critical effect for risk assessment. However, the mechanisms by which antibody concentrations are impacted are not completely understood. Furthermore, other targets of the immune system functions have been reported in the literature. Objective The aim of this review is to explore PFAS-associated immune-related effects. This includes, relevant mechanisms that may underlie the observed effects on the immune system, immunosuppression as well as immunoenhancement, such as i) modulation of cell signalling and nuclear receptors, such as NF-κB and PPARs; ii) alteration of calcium signalling and homoeostasis in immune cells; iii) modulation of immune cell populations; iv) oxidative stress and v) impact on fatty acid metabolism & secondary effects on the immune system. Methods A literature research was conducted using three databases (Web of Science, PubMed, and Scopus), which were searched in July 2021 for relevant studies published in the time frame from 2018 to 2021. In total, 487 publications were identified as potentially eligible and following expert-based judgement, articles relevant for mechanisms of PFAS induced immunotoxicity are discussed. Conclusions Taken together, we show that there is substantial evidence from both in vitro and in vivo experimental as well as epidemiological studies, supporting that various PFAS, not only PFOA and PFOS, affect multiple aspects of the immune system. Timing of exposure is critical, because the developing immune system is especially vulnerable to toxic insults, resulting in a higher risk of particularly adverse immune effects but also other organs later in life.
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- 2023
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44. The Effect of the Process Parameters on the Composition and Properties of Silica-Like Films Deposited by Atmospheric Pressure PECVD in the System TEOS-He-O2
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Bil, Anastasia S. and Alexandrov, Sergey E.
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- 2022
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45. The Randomized, Multicenter, Open-Label, Controlled POLBOS 3 Trial Comparing Regular Drug-Eluting Stents and the Sirolimus-Eluting BiOSS LIM C Dedicated Coronary Bifurcation Stent: Four-Year Results
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Robert J. Gil, Adam Kern, Krystian Bojko, Aneta Gziut-Rudkowska, Dobrin Vassilev, and Jacek Bil
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non-LM bifurcation ,percutaneous coronary intervention ,high-risk PCI ,long-term data ,Biology (General) ,QH301-705.5 - Abstract
This multicenter, randomized study aimed to compare the sirolimus-eluting BiOSS LIM C dedicated coronary bifurcation stent with second-generation -limus drug-eluting stents (rDESs) in the treatment of non-left main (non-LM) coronary bifurcation. The deployment of a single stent in the main vessel–main branch across a side branch was the default strategy in all patients. The primary endpoint was the rate of major cardiovascular events (cardiac death, myocardial infarction, and target lesion revascularization) at 48 months. We enrolled 230 patients, allocating 116 patients to the BiOSS LIM C group and 114 patients to the rDES group. Most procedures were elective (BiOSS vs. rDES: 48.3% vs. 59.6%, p = 0.09) and performed in bifurcations within the left anterior descending/diagonal branch (BiOSS vs. rDES: 51.7% vs. 61.4%, p = 0.15). At 48 months, there were no statistically significant differences between the BiOSS and rDES groups in terms of major adverse cardiovascular events (MACE), cardiac death, myocardial infarction (MI), or target lesion revascularization (TLR) as follows: MACEs—18.1% vs. 14.9%, HR 1.36, 95% CI 0.62–2.22, and p = 0.33; cardiac death—4.3% vs. 3.5%, HR 1.23, 95% CI 0.33–4.56, and p = 0.75; MI—2.6% vs. 3.5%, HR 0.73, 95% CI 0.17–3.23, and p = 0.68; and TLR—11.2% vs. 7.9%, HR 1.66, 95% CI 0.75–3.71, and p = 0.21. The implantation success rate of the BiOSS LIM C stent was very high, and the cumulative MACE rates were promising. The POLBOS 3 trial sets an important benchmark for treating non-LM coronary bifurcations (ClinicalTrials.gov NCT03548272).
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- 2024
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46. Mixture of Doxycycline, ML-7 and L-NAME Restores the Pro- and Antioxidant Balance during Myocardial Infarction—In Vivo Pig Model Study
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Iwona Bil-Lula, Wiktor Kuliczkowski, Anna Krzywonos-Zawadzka, Piotr Frydrychowski, Dominika Stygar, Kornela Hałucha, and Agnieszka Noszczyk-Nowak
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ischemia-reperfusion injury ,oxidative stress ,MI pig model ,pro- and antioxidant balance ,Biology (General) ,QH301-705.5 - Abstract
The restoration of blood flow to the ischemic myocardium inflicts ischemia/reperfusion (I/R) heart injury (IRI). The main contributors to IRI are increased oxidative stress and subsequent excessive production of ROS, increased expression of NOS and peroxinitate, activation of MMPs, and enhanced posttranslational modifications of contractile proteins, which make them more susceptible to proteolytic degradation. Since the pathophysiology of IRI is a complex issue, and thus, various therapeutic strategies are required to prevent or reduce IRI and microvascular dysfunction, in the current study we proposed an innovative multi-drug therapy using low concentrations of drugs applied intracoronary to reach microvessels in order to stabilize the pro- and antioxidant balance during a MI in an in vivo pig model. The ability of a mixture of doxycycline (1 μM), ML-7 (0.5 μM), and L-NAME (2 μM) to modulate the pro- and antioxidative balance was tested in the left ventricle tissue and blood samples. Data showed that infusion of a MIX reduced the total oxidative status (TOS), oxidative stress index (OSI), and malondialdehyde (MDA). It also increased the total antioxidant capacity, confirming its antioxidative properties. MIX administration also reduced the activity of MMP-2 and MMP-9, and then decreased the release of MLC1 and BNP-26 into plasma. This study demonstrated that intracoronary administration of low concentrations of doxycycline in combination with ML-7 and L-NAME is incredibly efficient in regulating pro- and antioxidant balance during MI.
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- 2024
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47. Assessment of Changes in Cap and Residual Stromal Thickness Values during a 6-Month Observation after Refractive Lenticule Extraction Small Incision Lenticule Extraction
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Dominika Janiszewska-Bil, Barbara Czarnota-Nowakowska, Izabela Kuciel-Polczak, Dariusz Dobrowolski, Beniamin Oskar Grabarek, Anita Lyssek-Boroń, Edward Wylęgała, and Joanna Wierzbowska
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refractive lenticule extraction small incision lenticule extraction ,ReLEx ,SMILE ,cap ,residual stromal thickness (RST) ,refractive surgery ,Medicine - Abstract
Background: In this study, the changes in corneal cap and residual stromal thickness (RST) values during a 180-day observation period after refractive lenticule extraction small incision lenticule extraction (ReLEx SMILE) were assessed. Methods: Fifty patients underwent ReLEx SMILE using the VisuMax 500 femtosecond laser, with corneal imaging conducted pre and post procedure via anterior segment optical coherence tomography (AS-OCT). Cap thickness in the center and 1.5 mm from the center in four meridians was measured at various intervals. Results: The results showed a significant decrease in cap thickness 180 days post procedure compared to earlier intervals (p < 0.05). Similarly, RST decreased gradually and significantly post procedure (p < 0.05). Notably, changes in cap thickness within the central 1.5 mm area were more dynamic than RST changes during the 6-month observation period following SMILE. Conclusions: The corneal cap thickness measured with swept-source AS-OCT within the central 1.5 mm area underwent more dynamic changes than the residual stromal thickness during the 6-month observation following SMILE.
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- 2024
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48. RhoA/ROCK Pathway Is Upregulated in Experimental Autoimmune Myocarditis and Is Inhibited by Simvastatin at the Stage of Myosin Light Chain Phosphorylation
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Monika Skrzypiec-Spring, Maciej Kaczorowski, Alina Rak-Pasikowska, Agnieszka Sapa-Wojciechowska, Krzysztof Kujawa, Agnieszka Żuryń, Iwona Bil-Lula, Agnieszka Hałoń, and Adam Szeląg
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immune system ,myocarditis ,molecular pathology ,RhoA/ROCK pathway ,simvastatin ,metalloproteinases ,Biology (General) ,QH301-705.5 - Abstract
Many studies have proven the involvement of the RhoA/ROCK pathway in autoimmune and cardiovascular diseases and the beneficial effects of its downregulation. Here, we examined whether the effect of simvastatin on experimental autoimmune myocarditis (EAM) may be through targeting the Ras homolog family member A/Rho-associated coiled-coil containing kinases (RhoA/ROCK) pathway and whether previously shown downregulation of metalloproteinase 9 (MMP-9) could be associated with MLC phosphorylation. Two doses of simvastatin were administered to experimental rats with autoimmune myocarditis by gastric gavage for 3 weeks, at the stage of development of the inflammatory process. Immunohistochemical staining for RhoA and ROCK1 was evaluated semi-quantitatively with H-score. The RhoA staining showed no significant differences in expression between the groups, but the ROCK1 expression was significantly upregulated in the hearts of the EAM group and was not downregulated by simvastatin. The Western blotting analysis of the last downstream product of the RhoA/ROCK axis, phosphorylated myosin light chain (phospho-MYL9), revealed that protein content increased in EAM hearts and it was prevented by the highest dose of simvastatin. Our findings suggest that the RhoA/ROCK pathway is upregulated in EAM, and simvastatin in EAM settings inhibits the RhoA/ROCK pathway at the stage of phosphorylation of myosin light chains and provides a new insight into the molecular pathology of autoimmune myocarditis.
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- 2024
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49. In Vivo Study on Doxycycline Protective Mechanisms during Myocardial Ischemia Injury in Rats
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Anna Krzywonos-Zawadzka, Agnieszka Olejnik, Grzegorz Sawicki, and Iwona Bil-Lula
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doxycycline ,rat myocardial infraction ,LAD ,MMPs ,MLC1 ,ischemic heart disease ,Biology (General) ,QH301-705.5 - Abstract
Background: The fact that during myocardial ischemia/reperfusion (I/R) injury, myosin light chain 1 (MLC1) and troponin I (TnI) are degraded by matrix metalloproteases activity has already been well established in both in vitro and ex vivo studies. However, I/R injury is a complex issue based on several overlapping mechanisms. Increased activity of myosin light chain kinase and nitric oxide synthase due to oxidative stress leads to post-translational modifications of MLC1, thus leading to the increased degradation of these proteins. Methods: Wistar rats were subjected to left anterior descending coronary artery occlusion. To measure the pharmacological effect of doxycycline, transthoracic echocardiography as well as biochemical tests, concentrations of TnI, LDH, MLC1, MMP-2 and MMP-9 were performed. Gelatinize activity and cytotoxicity level were also assessed; Results: I.p., administration of doxycycline before LAD occlusion surgery increased TnI and LDH content in the heart and decreased cytotoxicity. A reduction of MMP-2 and MMP-9 concentration and MMP-2 activity after administration of Doxy was also observed, as well as improvement in echocardiographic parameters just 7 days after surgery. Conclusions: Inhibition of MMPs by doxycycline, in vivo, may serve as a protective agent in future therapy.
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- 2024
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50. The Effect of Leukocyte Removal and Matrix Metalloproteinase Inhibition on Platelet Storage Lesions
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Alina Rak-Pasikowska, Kornela Hałucha, Agnieszka Sapa-Wojciechowska, Aneta Wrzyszcz, Wioletta Gałuszka, Anna Pęcak-Solińska, and Iwona Bil-Lula
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blood platelets ,matrix metalloproteinases ,platelet activation ,platelet transfusion ,Cytology ,QH573-671 - Abstract
The reasons for unfavorable changes in platelet concentrate (PC) quality during storage are not fully understood yet. We aimed to evaluate whether leukocytes and matrix metalloproteinases (MMPs) lead to a decrease in the quality of PCs and examine whether MMP inhibition will slow down the platelets’ aging. Nine PCs were divided into three parts: (1) leukocyte-depleted (F) PCs, (2) PCs with no additional procedures (NF), and (3) PCs with the addition of an MMP inhibitor—doxycycline (D). Each PC was stored for 144 h, and a sample for testing was separated from each part on the day of preparation and after 24, 48, 72 and 144 h of storage. Blood morphological analysis, platelet aggregation, and the expression of activation markers were evaluated. MMP-2 and MMP-9 concentration, activity, and gene expression were assessed. Platelet aggregation decreased, and platelet activation marker expression increased during the storage. D concentrates showed the lowest level of platelet activation. In turn, leukocyte-depleted PCs showed the highest level of platelet activation in general. MMP-9 platelet activity was higher in leukocyte-containing concentrates at the end of the storage period. We concluded that the filtration process leads to a higher platelet activation level. The presence of doxycycline in PCs reduces the expression of the activation markers as compared to leukocyte-depleted concentrates.
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- 2024
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