156 results on '"Bijlenga, D"'
Search Results
2. Prevalence of sexual dysfunctions and other sexual disorders in adults with attention-deficit/hyperactivity disorder compared to the general population
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Bijlenga, D., Vroege, J. A., Stammen, A. J. M., Breuk, M., Boonstra, A. M., van der Rhee, K., and Kooij, J. J. S.
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- 2018
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3. Attention-deficit hyperactivity disorder symptoms add risk to circadian rhythm sleep problems in depression and anxiety
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Bron, T.I., Bijlenga, D., Kooij, J.J.S., Vogel, S.W.N., Wynchank, D., Beekman, A.T.F., and Penninx, B.W.J.H.
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- 2016
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4. Objective QbTest and subjective evaluation of stimulant treatment in adult attention deficit-hyperactivity disorder
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Bijlenga, D., Jasperse, M., Gehlhaar, S.K., and Sandra Kooij, J.J.
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- 2015
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5. Applicability of the Sustained Attention to Response Task (SART) in clinical practice: experience and results from a Tertiary Referral Center
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van der Hoeven, A.E., primary, Bijlenga, D., additional, Bouhuijs, P., additional, van Schie, M.K.M., additional, Lammers, G.J., additional, and Fronczek, R., additional
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- 2022
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6. Skin temperature is associated with on-the-road driving performance in patients with central disorders of hypersomnolence
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Vael, V.E.C., primary, Bijlenga, D., additional, Schinkelshoek, M.S., additional, Lammers, G.J., additional, and Fronczek, R., additional
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- 2022
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7. Induction versus expectant monitoring for intrauterine growth restriction at term: randomised equivalence trial (DIGITAT)
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Boers, K E, Vijgen, S M C, Bijlenga, D, van der Post, J A M, Bekedam, D J, Kwee, A, van der Salm, P C M, van Pampus, M G, Spaanderman, M E A, de Boer, K, Duvekot, J J, Bremer, H A, Hasaart, T H M, Delemarre, F M C, Bloemenkamp, K W M, van Meir, C A, Willekes, C, Wijnen, E J, Rijken, M, le Cessie, S, Roumen, F J M E, Thornton, J, van Lith, J M M, Mol, B W J, and Scherjon, S A
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- 2011
8. Induction versus expectant monitoring for intrauterine growth restriction at term: randomised equivalence trial (DIGITAT)
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Boers, K E, Vijgen, S M C, Bijlenga, D, van der Post, J A M, Bekedam, D J, Kwee, A, van der Salm, P C M, van Pampus, M G, Spaanderman, M E A, de Boer, K, Duvekot, J J, Bremer, H A, Hasaart, T H M, Delemarre, F M C, Bloemenkamp, K W M, van Meir, C A, Willekes, C, Wijnen, E J, Rijken, M, le Cessie, S, Roumen, F J M E, Thornton, J G, van Lith, J M M, Mol, B W J, and Scherjon, S A
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- 2010
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9. An economic analysis of induction of labour and expectant monitoring in women with gestational hypertension or pre-eclampsia at term (HYPITAT trial)
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Vijgen, S MC, Koopmans, C M, Opmeer, B C, Groen, H, Bijlenga, D, Aarnoudse, J G, Bekedam, D J, Van Den Berg, P P, De Boer, K, Burggraaff, J M, Bloemenkamp, K WM, Drogtrop, A P, Franx, A, De Groot, C JM, Huisjes, A JM, Kwee, A, Van Loon, A J, Lub, A, Papatsonis, D NM, Van Der Post, J AM, Roumen, F JME, Scheepers, H CJ, Stigter, R H, Willekes, C, Mol, B WJ, and Van Pampus, M G
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- 2010
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10. Updated European Consensus Statement on diagnosis and treatment of adult ADHD
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Kooij, J. J. S. Bijlenga, D. Salerno, L. Jaeschke, R. and Bitter, I Balazs, J. Thome, J. Dom, G. Kasper, S. and Nunes Filipe, C. Stes, S. Mohr, P. Leppamaki, S. Casas, M. Bobes, J. Mccarthy, J. M. Richarte, V Philipsen, A. Kjems Pehlivanidis, A. Niemela, A. Styr, B. Semerci, B. and Bolea-Alamanac, B. Edvinsson, D. Baeyens, D. Wynchank, D. Sobanski, E. Philipsen, A. McNicholas, F. Caci, H. and Mihailescu, I Manor, I Dobrescu, I Saito, T. Krause, J. Fayyad, J. Ramos-Quiroga, J. A. Foeken, K. Rad, F. and Adamou, M. Ohlmeier, M. Fitzgerald, M. Gill, M. and Lensing, M. Mukaddes, N. Motavalli Brudkiewicz, P. and Gustafsson, P. Tani, P. Oswald, P. Carpentier, P. J. De Rossi, P. Delorme, R. Simoska, S. Markovska Pallanti, S. and Young, S. Bejerot, S. Lehtonen, T. Kustow, J. and Mueller-Sedgwick, U. Hirvikoski, T. Pironti, V Ginsberg, Y. and Felegyhazy, Z. Garcia-Portilla, M. P. Asherson, P.
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mental disorders ,behavioral disciplines and activities - Abstract
Background Attention-deficit/hyperactivity disorder (ADHD) is among the most common psychiatric disorders of childhood that often persists into adulthood and old age. Yet ADHD is currently underdiagnosed and undertreated in many European countries, leading to chronicity of symptoms and impairment, due to lack of, or ineffective treatment, and higher costs of illness. Methods The European Network Adult ADHD and the Section for Neurodevelopmental Disorders Across the Lifespan (NDAL) of the European Psychiatric Association (EPA), aim to increase awareness and knowledge of adult ADHD in and outside Europe. This Updated European Consensus Statement aims to support clinicians with research evidence and clinical experience from 63 experts of European and other countries in which ADHD in adults is recognized and treated. Results Besides reviewing the latest research on prevalence, persistence, genetics and neurobiology of ADHD, three major questions are addressed: (1) What is the clinical picture of ADHD in adults? (2) How should ADHD be properly diagnosed in adults? (3) How should adult ADHDbe effectively treated? Conclusions ADHD often presents as a lifelong impairing condition. The stigma surrounding ADHD, mainly due to lack of knowledge, increases the suffering of patients. Education on the lifespan perspective, diagnostic assessment, and treatment of ADHD must increase for students of general and mental health, and for psychiatry professionals. Instruments for screening and diagnosis of ADHD in adults are available, as are effective evidence-based treatments for ADHD and its negative outcomes. More research is needed on gender differences, and in older adults with ADHD. (c) 2018 The Author(s). Published by Elsevier Masson SAS.
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- 2019
11. Updated European Consensus Statement on diagnosis and treatment of adult ADHD
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Kooij, J. J. S., Bijlenga, D., Salerno, L., Jaeschke, R., Bitter, I, Balazs, J., Thome, J., Dom, G., Kasper, S., Nunes Filipe, C., Stes, S., Mohr, P., Leppamaki, S., Casas, M., Bobes, J., Mccarthy, J. M., Richarte, V, Philipsen, A. Kjems, Pehlivanidis, A., Niemela, A., Styr, B., Semerci, B., Bolea-Alamanac, B., Edvinsson, Dan, Baeyens, D., Wynchank, D., Sobanski, E., Philipsen, A., McNicholas, F., Caci, H., Mihailescu, I, Manor, I, Dobrescu, I, Saito, T., Krause, J., Fayyad, J., Ramos-Quiroga, J. A., Foeken, K., Rad, F., Adamou, M., Ohlmeier, M., Fitzgerald, M., Gill, M., Lensing, M., Mukaddes, N. Motavalli, Brudkiewicz, P., Gustafsson, P., Tani, P., Oswald, P., Carpentier, P. J., De Rossi, P., Delorme, R., Simoska, S. Markovska, Pallanti, S., Young, S., Bejerot, S., Lehtonen, T., Kustow, J., Mueller-Sedgwick, U., Hirvikoski, T., Pironti, V, Ginsberg, Y., Felegyhazy, Z., Garcia-Portilla, M. P., Asherson, P., Kooij, J. J. S., Bijlenga, D., Salerno, L., Jaeschke, R., Bitter, I, Balazs, J., Thome, J., Dom, G., Kasper, S., Nunes Filipe, C., Stes, S., Mohr, P., Leppamaki, S., Casas, M., Bobes, J., Mccarthy, J. M., Richarte, V, Philipsen, A. Kjems, Pehlivanidis, A., Niemela, A., Styr, B., Semerci, B., Bolea-Alamanac, B., Edvinsson, Dan, Baeyens, D., Wynchank, D., Sobanski, E., Philipsen, A., McNicholas, F., Caci, H., Mihailescu, I, Manor, I, Dobrescu, I, Saito, T., Krause, J., Fayyad, J., Ramos-Quiroga, J. A., Foeken, K., Rad, F., Adamou, M., Ohlmeier, M., Fitzgerald, M., Gill, M., Lensing, M., Mukaddes, N. Motavalli, Brudkiewicz, P., Gustafsson, P., Tani, P., Oswald, P., Carpentier, P. J., De Rossi, P., Delorme, R., Simoska, S. Markovska, Pallanti, S., Young, S., Bejerot, S., Lehtonen, T., Kustow, J., Mueller-Sedgwick, U., Hirvikoski, T., Pironti, V, Ginsberg, Y., Felegyhazy, Z., Garcia-Portilla, M. P., and Asherson, P.
- Abstract
Background Attention-deficit/hyperactivity disorder (ADHD) is among the most common psychiatric disorders of childhood that often persists into adulthood and old age. Yet ADHD is currently underdiagnosed and undertreated in many European countries, leading to chronicity of symptoms and impairment, due to lack of, or ineffective treatment, and higher costs of illness. Methods The European Network Adult ADHD and the Section for Neurodevelopmental Disorders Across the Lifespan (NDAL) of the European Psychiatric Association (EPA), aim to increase awareness and knowledge of adult ADHD in and outside Europe. This Updated European Consensus Statement aims to support clinicians with research evidence and clinical experience from 63 experts of European and other countries in which ADHD in adults is recognized and treated. Results Besides reviewing the latest research on prevalence, persistence, genetics and neurobiology of ADHD, three major questions are addressed: (1) What is the clinical picture of ADHD in adults? (2) How should ADHD be properly diagnosed in adults? (3) How should adult ADHDbe effectively treated? Conclusions ADHD often presents as a lifelong impairing condition. The stigma surrounding ADHD, mainly due to lack of knowledge, increases the suffering of patients. Education on the lifespan perspective, diagnostic assessment, and treatment of ADHD must increase for students of general and mental health, and for psychiatry professionals. Instruments for screening and diagnosis of ADHD in adults are available, as are effective evidence-based treatments for ADHD and its negative outcomes. More research is needed on gender differences, and in older adults with ADHD.
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- 2019
- Full Text
- View/download PDF
12. Updated European Consensus Statement on diagnosis and treatment of adult ADHD
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Kooij, J.J.S., Bijlenga, D., Salerno, L., Jaeschke, R., Bitter, I., Balázs, J., Thome, J., Dom, Geert, Kasper, S., Nunes Filipe, C., Stes, S., Mohr, Pavel, Leppämäki, S., Casas, Miquel, Bobes, J., Mccarthy, J.M., Richarte, Vanesa, Kjems Philipsen, A., Pehlivanidis, A., Niemela, A., Styr, B., Semerci, B., Bolea-Alamanac, B., Edvinsson, Dan, Baeyens, D., Wynchank, D., Sobanski, E., Philipsen, A., Caci, H., Mihailescu, I., Manor, I., Dobrescu, I., Krause, J., Fayyad, J., Ramos-Quiroga, Josep Antoni, Foeken, K., Rad, F., Adamou, M., Ohlmeier, M., Fitzgerald, M., Gill, M., Lensing, M., Motavalli Mukaddes, N., Brudkiewicz, P., Gustafsson, P., Tani, P., Carpentier, P.J., De Rossi, P., Delorme, R., Markovska Simoska, S., Pallanti, S., Young, S., Bejerot, S., Lehtonen, T., Kustow, J., Müller-Sedgwick, U., Hirvikoski, T., Pironti, V., Ginsberg, Y., Félegeházy, Z., García-Portilla, Maria-Paz, Asherson, Philip, Kooij, J.J.S., Bijlenga, D., Salerno, L., Jaeschke, R., Bitter, I., Balázs, J., Thome, J., Dom, Geert, Kasper, S., Nunes Filipe, C., Stes, S., Mohr, Pavel, Leppämäki, S., Casas, Miquel, Bobes, J., Mccarthy, J.M., Richarte, Vanesa, Kjems Philipsen, A., Pehlivanidis, A., Niemela, A., Styr, B., Semerci, B., Bolea-Alamanac, B., Edvinsson, Dan, Baeyens, D., Wynchank, D., Sobanski, E., Philipsen, A., Caci, H., Mihailescu, I., Manor, I., Dobrescu, I., Krause, J., Fayyad, J., Ramos-Quiroga, Josep Antoni, Foeken, K., Rad, F., Adamou, M., Ohlmeier, M., Fitzgerald, M., Gill, M., Lensing, M., Motavalli Mukaddes, N., Brudkiewicz, P., Gustafsson, P., Tani, P., Carpentier, P.J., De Rossi, P., Delorme, R., Markovska Simoska, S., Pallanti, S., Young, S., Bejerot, S., Lehtonen, T., Kustow, J., Müller-Sedgwick, U., Hirvikoski, T., Pironti, V., Ginsberg, Y., Félegeházy, Z., García-Portilla, Maria-Paz, and Asherson, Philip
- Abstract
Background Attention-deficit/hyperactivity disorder (ADHD) is among the most common psychiatric disorders of childhood that often persists into adulthood and old age. Yet ADHD is currently underdiagnosed and undertreated in many European countries, leading to chronicity of symptoms and impairment, due to lack of, or ineffective treatment, and higher costs of illness. Methods The European Network Adult ADHD and the Section for Neurodevelopmental Disorders Across the Lifespan (NDAL) of the European Psychiatric Association (EPA), aim to increase awareness and knowledge of adult ADHD in and outside Europe. This Updated European Consensus Statement aims to support clinicians with research evidence and clinical experience from 63 experts of European and other countries in which ADHD in adults is recognized and treated. Results Besides reviewing the latest research on prevalence, persistence, genetics and neurobiology of ADHD, three major questions are addressed: (1) What is the clinical picture of ADHD in adults? (2) How should ADHD be properly diagnosed in adults? (3) How should adult ADHDbe effectively treated? Conclusions ADHD often presents as a lifelong impairing condition. The stigma surrounding ADHD, mainly due to lack of knowledge, increases the suffering of patients. Education on the lifespan perspective, diagnostic assessment, and treatment of ADHD must increase for students of general and mental health, and for psychiatry professionals. Instruments for screening and diagnosis of ADHD in adults are available, as are effective evidence-based treatments for ADHD and its negative outcomes. More research is needed on gender differences, and in older adults with ADHD.
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- 2019
13. Updated European Consensus Statement on diagnosis and treatment of adult ADHD
- Author
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Kooij, J.J.S., primary, Bijlenga, D., additional, Salerno, L., additional, Jaeschke, R., additional, Bitter, I., additional, Balázs, J., additional, Thome, J., additional, Dom, G., additional, Kasper, S., additional, Nunes Filipe, C., additional, Stes, S., additional, Mohr, P., additional, Leppämäki, S., additional, Casas, M., additional, Bobes, J., additional, Mccarthy, J.M., additional, Richarte, V., additional, Kjems Philipsen, A., additional, Pehlivanidis, A., additional, Niemela, A., additional, Styr, B., additional, Semerci, B., additional, Bolea-Alamanac, B., additional, Edvinsson, D., additional, Baeyens, D., additional, Wynchank, D., additional, Sobanski, E., additional, Philipsen, A., additional, McNicholas, F., additional, Caci, H., additional, Mihailescu, I., additional, Manor, I., additional, Dobrescu, I., additional, Saito, T., additional, Krause, J., additional, Fayyad, J., additional, Ramos-Quiroga, J.A., additional, Foeken, K., additional, Rad, F., additional, Adamou, M., additional, Ohlmeier, M., additional, Fitzgerald, M., additional, Gill, M., additional, Lensing, M., additional, Motavalli Mukaddes, N., additional, Brudkiewicz, P., additional, Gustafsson, P., additional, Tani, P., additional, Oswald, P., additional, Carpentier, P.J., additional, De Rossi, P., additional, Delorme, R., additional, Markovska Simoska, S., additional, Pallanti, S., additional, Young, S., additional, Bejerot, S., additional, Lehtonen, T., additional, Kustow, J., additional, Müller-Sedgwick, U., additional, Hirvikoski, T., additional, Pironti, V., additional, Ginsberg, Y., additional, Félegyházy, Z., additional, Garcia-Portilla, M.P., additional, and Asherson, P., additional
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- 2018
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14. Neuropsychological deficits in adults age 60 and above with attention deficit hyperactivity disorder
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Thorell, L.B., primary, Holst, Y., additional, Chistiansen, H., additional, Kooij, J.J.S., additional, Bijlenga, D., additional, and Sjöwall, D., additional
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- 2017
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15. Prevalence of sexual dysfunctions and other sexual disorders in adults with attention-deficit/hyperactivity disorder compared to the general population
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Bijlenga, D., primary, Vroege, J. A., additional, Stammen, A. J. M., additional, Breuk, M., additional, Boonstra, A. M., additional, van der Rhee, K., additional, and Kooij, J. J. S., additional
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- 2017
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16. Atypical sensory profiles as core features of adult ADHD, irrespective of autistic symptoms
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Bijlenga, D., primary, Tjon-Ka-Jie, J.Y.M., additional, Schuijers, F., additional, and Kooij, J.J.S., additional
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- 2017
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17. Economic analysis comparing induction of labor and expectant management in women with preterm prelabor rupture of membranes between 34 and 37 weeks (PPROMEXIL trial)
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Vijgen, S.M., Ham, D.P. van der, Bijlenga, D., Beek, J.J. van, Bloemenkamp, K.W., Kwee, A., Groenewout, M., Kars, M.M., Kuppens, S., Mantel, G., Molkenboer, J.F., Mulder, A.L., Nijhuis, J.G., Pernet, P.J., Porath, M., Woiski, M.D., Weinans, M.J., Wijngaarden, W.J. van, Wildschut, H.I.J., Akerboom, B., Sikkema, J.M., Willekes, C., Mol, B.W., Opmeer, B.C., Other departments, Obstetrics and Gynaecology, Clinical Research Unit, Huisartsgeneeskunde, MUMC+: MA Medische Staf Kindergeneeskunde (9), Kindergeneeskunde, MUMC+: MA Obstetrie Gynaecologie (3), Obstetrie & Gynaecologie, MUMC+: MA Medische Staf Obstetrie Gynaecologie (9), RS: GROW - Developmental Biology, and RS: GROW - R4 - Reproductive and Perinatal Medicine
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Adult ,Fetal Membranes, Premature Rupture ,Pediatrics ,medicine.medical_specialty ,Cost Control ,Critical Care ,Cost-Benefit Analysis ,Pregnancy Trimester, Third ,Population ,labor ,law.invention ,DISTRESS ,Randomized controlled trial ,Cost Savings ,Pregnancy ,law ,Sepsis ,Humans ,Medicine ,Rupture of membranes ,Labor, Induced ,Watchful Waiting ,education ,induction ,Monitoring, Physiologic ,Netherlands ,expectant management ,Analgesics ,education.field_of_study ,Neonatal sepsis ,business.industry ,Obstetrics ,Incidence ,Incidence (epidemiology) ,Other Research Radboud Institute for Health Sciences [Radboudumc 0] ,Infant, Newborn ,Obstetrics and Gynecology ,General Medicine ,Length of Stay ,Delivery, Obstetric ,medicine.disease ,Confidence interval ,Costs ,Relative risk ,Intensive Care, Neonatal ,Female ,PPROM ,business ,Postpartum period - Abstract
ObjectiveTo compare the costs of induction of labor and expectant management in women with preterm prelabor rupture of membranes (PPROM).DesignEconomic analysis based on a randomized clinical trial.SettingObstetric departments of eight academic and 52 non-academic hospitals in the Netherlands.PopulationWomen with PPROM near term who were not in labor 24h after PPROM.MethodsA cost-minimization analysis was done from a health care provider perspective, using a bottom-up approach to estimate resource utilization, valued with unit-costs reflecting actual costs.Main outcome measuresPrimary health outcome was the incidence of neonatal sepsis. Direct medical costs were estimated from start of randomization to hospital discharge of mother and child.ResultsInduction of labor did not significantly reduce the probability of neonatal sepsis [2.6% vs. 4.1%, relative risk 0.64 (95% confidence interval 0.25-1.6)]. Mean costs per woman were Euro8094 for induction and Euro7340 for expectant management (difference Euro754; 95% confidence interval -335 to 1802). This difference predominantly originated in the postpartum period, where the mean costs were Euro5669 for induction vs. Euro4801 for expectant management. Delivery costs were higher in women allocated to induction than in women allocated to expectant management (Euro1777 vs. Euro1153 per woman). Antepartum costs in the expectant management group were higher because of longer antepartum maternal stays in hospital.ConclusionsIn women with pregnancies complicated by PPROM near term, induction of labor does not reduce neonatal sepsis, whereas costs associated with this strategy are probably higher.
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- 2014
18. Economic analysis of induction of labor versus expectant management in women with preterm prelabor rupture of membranes between 34 and 37 weeks (PPROMEXIL trial ISRCTN29313500)
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Mol, B., Vijgen, S., Opmeer, B., Bijlenga, D., Akerboom, B., Wijngaarden, W. van, Kuppens, S., Wildschut, H., Weinans, M., Mantel, G., Pernet, P., Bloemenkamp, K., Mulder, T., Ham, D. van der, Nijhuis, J., Willekes, C., Porath, M., Molkenboer, J., Kars, M., Sikkema, M., Groenewout, M., Spaanderman, M., Derks, J., and Beek, J. van
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- 2011
19. Women and/or children first. Methods to handle multiple outcomes in obstetrics
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Bijlenga, D., Bonsel, Gouke J., Mol, Bernardus W. J., Birnie, E., Obstetrics and Gynaecology, Bonsel, G.J., Mol, B.W.J., and Faculteit der Geneeskunde
- Abstract
Denise Bijlenga behandelt methodologische aspecten van onderzoek naar complexe beslissingen, toegespitst op verloskunde. Belangrijk onderdeel vormt health technology assesment (HTA), methodologische studies die tegelijkertijd met klinische trials worden uitgevoerd om de verschillende uitkomsten van die trials om te kunnen zetten in één overkoepelende uitkomst: de preferentie. Bijlenga vergeleek bestaande waarderingsmethoden voor gezondheidstoestanden en antwoorden van verschillende groepen (artsen, patiënten, leken). Artsen laten zich in hun preferenties meer leiden door de gezondheidstoestand van de moeder; patiënten en leken meer door die van de baby.
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- 2010
20. Liever inleiden dan afwachten bij aterme zwangerschapshypertensie en milde preëclampsie: HYPITAT-studie*
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Koopmans, C. M., Bijlenga, D., Groen, H., Vijgen, S. M. C., Aarnoudse, J. G., Bekedam, D. J., van den Berg, P. P., de Boer, K., Burggraaff, J. M., Bloemenkamp, K. W. M., Drogtrop, A. P., Franx, A., de Groot, C. J. M., Huisjes, A. J. M., Kwee, A., van Loon, A. J., Lub, A., Papatsonis, D. N. M., van der Post, J. A. M., Roumen, F. J. M. E., Scheepers, H. C. J., Willekes, C., Mol, B. W. J., van Pampus, M. G., Obstetrics and gynaecology, ICaR - Ischemia and repair, Science in Healthy Ageing & healthcaRE (SHARE), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Reproductive Origins of Adult Health and Disease (ROAHD), Other departments, Amsterdam Reproduction & Development (AR&D), Obstetrics and Gynaecology, and Amsterdam Public Health
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reproductive and urinary physiology - Abstract
OBJECTIVE: To investigate what would benefit women with mild full-term pregnancy-related hypertension most: induction of labour or expectant monitoring, from the perspective of clinical effectiveness, maternal quality of life, and costs. DESIGN: Randomised clinical trial. Trial registration number ISRCTN08132825. METHODS: We undertook a multicentre randomised controlled trial in 38 hospitals in the Netherlands between October 2005 and March 2008. We enrolled patients with a singleton pregnancy in cephalic presentation at 36-41 weeks' gestation, who had gestational hypertension or mild preeclampsia. Participants were randomly allocated to receive either induction of labour or expectant monitoring. The primary outcome was a composite measure of poor maternal outcome, defined as maternal mortality, maternal morbidity (eclampsia, 'haemolysis, elevated liver enzymes, low platelets' (HELLP) syndrome, pulmonary oedema, thrombo-embolic disease and abruptio placentae), progression to severe hypertension or proteinuria, and major postpartum haemorrhage. Secondary outcomes were mode of delivery, neonatal outcome, maternal quality of life and costs. Analysis was by intention to treat. RESULTS: A total of 756 patients were allocated to receive induction of labour (n = 377 patients) or expectant monitoring (n = 379). No cases of maternal or neonatal death or eclampsia were recorded. Development of poor maternal outcome was significantly lower in the induction of labour group (117 women) than the expectant monitoring group (166 women) (31% versus 44%; relative risk 0.71 (95% CI: 0.59-0.86); p < 0.001). The caesarean section rate was lower among women in the induction of labour group (n = 54) compared to women in the expectant monitoring group (n = 72) (14% versus 19%; relative risk 0.75 (95% CI: 0.55-1.04)< p = 0.085). Neonatal outcomes and quality of life were comparable between both groups. Induction of labour is a cost saving strategy (difference euro 831). CONCLUSION: For women with full-term gestational hypertension and pre-eclampsia, induction of labour is associated with improved maternal outcome and lower costs, without the additional risk of a caesarean section being necessary
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- 2010
21. Body temperature, activity and melatonin profiles in adults with attention-deficit/hyperactivity disorder and delayed sleep: a case-control study.
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Bijlenga, D, Van Someren, E.J.W., Gruber, R, Bron, T.I., Kruithof, I.F., Spanbroek, E.C.A., Kooij, J.J.S., Bijlenga, D, Van Someren, E.J.W., Gruber, R, Bron, T.I., Kruithof, I.F., Spanbroek, E.C.A., and Kooij, J.J.S.
- Published
- 2013
22. Associations between sleep characteristics, seasonal depressive symptoms, lifestyle, and ADHD symptoms in adults.
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Bijlenga, D, Van der Heijden, K.B., Breuk, M, Van Someren, E.J.W., Lie, M.E., Boonstra, A.M., Swaab, H.J., Kooij, J., Bijlenga, D, Van der Heijden, K.B., Breuk, M, Van Someren, E.J.W., Lie, M.E., Boonstra, A.M., Swaab, H.J., and Kooij, J.
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- 2013
23. Health-related quality of life after induction of labor versus expectant monitoring in gestational hypertension or preeclampsia at term
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Bijlenga, D., Koopmans, C.M., Birnie, E., Mol, B.W., Post, J.A. van der, Bloemenkamp, K.W., Scheepers, H.C.J., Willekes, C., Kwee, A., Heres, M.H., Beek, E. van, Meir, C.A. van, Huizen, M.E. van, Pampus, M.G. van, Bonsel, G.J., Bijlenga, D., Koopmans, C.M., Birnie, E., Mol, B.W., Post, J.A. van der, Bloemenkamp, K.W., Scheepers, H.C.J., Willekes, C., Kwee, A., Heres, M.H., Beek, E. van, Meir, C.A. van, Huizen, M.E. van, Pampus, M.G. van, and Bonsel, G.J.
- Abstract
Item does not contain fulltext, OBJECTIVE: Gestational hypertension (GH) and preeclampsia (PE) are major contributors to maternal and neonatal morbidity and mortality. In GH or PE, labor may be either induced or monitored expectantly. We studied maternal health-related quality of life (HR-QoL) after induction of labor versus expectant monitoring in GH or PE at term. We performed the HR-QoL study alongside a multicenter randomized controlled trial comparing induction of labor to expectant monitoring in women with GH or PE after 36 weeks. METHODS: We used written questionnaires, covering background characteristics, condition-specific issues, and validated measures: the Short-Form (SF-36), European Quality of Life (EuroQoL 6D3L), Hospital Anxiety and Depression Scale (HADS), and Symptom Checklist (SCL-90). Measurements were at the following time points: baseline, 6 weeks postpartum, and 6 months postpartum. A multivariate mixed model with repeated measures was defined to assess the effect of the treatments on the physical component score (PCS) and mental component score (MCS) of the SF-36. Analysis was by intention to treat. RESULTS: We analyzed the data of 491 randomized and 220 nonrandomized women. We did not find treatment effect on long-term HR-QoL (PCS: p = 0.09; MCS: p = 0.82). The PCS improved over time (p < 0.001) and was better in nonrandomized patients (p = 0.02). CONCLUSION: Despite a clinical benefit of induction of labor, long-term HR-QoL is equal after the induction of labor and expectant management in women with GH or PE beyond 36 weeks of gestation.
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- 2011
24. Maternal health-related quality of life after induction of labor or expectant monitoring in pregnancy complicated by intrauterine growth retardation beyond 36 weeks
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Bijlenga, D. (Denise), Boers, K.E. (Kim), Birnie, E. (Erwin), Mol, B.W.J. (Ben), Vijgen, S.C.M. (Sylvia), Post, J.A.M. (Joris) van der, Groot, C.J.M. (Christianne) de, Rijnders, R.J.P. (Robbert), Pernet, P.J. (Paula), Roumen, F.J.M.E. (Frans), Stigter, R.H. (Rob), Delemarre, F.M.C. (Friso), Bremer, H.A. (Henk), Porath, M. (Martina), Scherjon, S.A. (Sico), Bonsel, G.J. (Gouke), Bijlenga, D. (Denise), Boers, K.E. (Kim), Birnie, E. (Erwin), Mol, B.W.J. (Ben), Vijgen, S.C.M. (Sylvia), Post, J.A.M. (Joris) van der, Groot, C.J.M. (Christianne) de, Rijnders, R.J.P. (Robbert), Pernet, P.J. (Paula), Roumen, F.J.M.E. (Frans), Stigter, R.H. (Rob), Delemarre, F.M.C. (Friso), Bremer, H.A. (Henk), Porath, M. (Martina), Scherjon, S.A. (Sico), and Bonsel, G.J. (Gouke)
- Abstract
Objective: Pregnancies complicated by intrauterine growth retardation (IUGR) beyond 36 weeks of gestation are at increased risk of neonatal morbidity and mortality. Optimal treatment in IUGR at term is highly debated. Results from the multicenter DIGITAT (Disproportionate Intrauterine Growth Intervention Trial At Term) trial show that induction of labor and expectant monitoring result in equal neonatal and maternal outcomes for comparable cesarean section rates. We report the maternal health-related quality of life (HR-QoL) that was measured alongside the trial at several points in time. Methods: Both randomized and non-randomized women were asked to participate in the HR-QoL study. Women were asked to fill out written validated questionnaires, covering background characteristics, condition-specific issues and the Short Form (SF-36), European Quality of Life (EuroQoL 6D3L), Hospital Anxiety and Depression scale (HADS), and Symptom Check List (SCL-90) at baseline, 6 weeks postpartum and 6 months postpartum. We compared the difference scores of all summary measures between the two management strategies by ANOVA. A repeated measures multivariate mixed model was
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- 2011
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25. Obstetrical outcome valuations by patients, professionals, and laypersons: Differences within and between groups using three valuation methods
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Bijlenga, D. (Denise), Birnie, E. (Erwin), Mol, B.W.J. (Ben), Bonsel, G.J. (Gouke), Bijlenga, D. (Denise), Birnie, E. (Erwin), Mol, B.W.J. (Ben), and Bonsel, G.J. (Gouke)
- Abstract
Background: Decision-making can be based on treatment preferences of the patient, the doctor, or by guidelines based on lay people's preferences. We compared valuations assigned by three groups: patients, obstetrical care professionals, and laypersons, for health states involving both mother and (unborn) child. Our aim was to compare the valuations of different groups using different valuation methods and complex obstetric health outcome vignettes that involve both maternal and neonatal out
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- 2011
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26. Induction versus expectant monitoring for intrauterine growth restriction at term: Randomised equivalence trial (DIGITAT)
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Boers, K.E. (Kim), Vijgen, S.M.C. (Sylvia), Bijlenga, D. (Denise), Post, J.A.M. (Joris) van der, Bekedam, D.J. (Dick), Kwee, A. (Anneke), Salm, P.C.M. van der, Pampus, M.G. (Maria) van, Spaanderman, M.E.A., Boer, K. (Karin) de, Duvekot, J.J. (Hans), Bremer, H.A. (Henk), Hasaart, T.H.M. (Tom), Delemarre, F.M.C. (Friso), Bloemenkamp, K.W.M. (Kitty), Meir, C.A. (Claudia) van, Willekes, C. (Christine), Wijnen, E.J., Rijken, M. (Monique), Cessie, S. (Saskia) le, Roumen, F.J.M.E. (Frans), Thornton, J.G., Lith, J.M.M. (Jan) van, Mol, B.W.J. (Ben), Scherjon, S.A. (Sico), Boers, K.E. (Kim), Vijgen, S.M.C. (Sylvia), Bijlenga, D. (Denise), Post, J.A.M. (Joris) van der, Bekedam, D.J. (Dick), Kwee, A. (Anneke), Salm, P.C.M. van der, Pampus, M.G. (Maria) van, Spaanderman, M.E.A., Boer, K. (Karin) de, Duvekot, J.J. (Hans), Bremer, H.A. (Henk), Hasaart, T.H.M. (Tom), Delemarre, F.M.C. (Friso), Bloemenkamp, K.W.M. (Kitty), Meir, C.A. (Claudia) van, Willekes, C. (Christine), Wijnen, E.J., Rijken, M. (Monique), Cessie, S. (Saskia) le, Roumen, F.J.M.E. (Frans), Thornton, J.G., Lith, J.M.M. (Jan) van, Mol, B.W.J. (Ben), and Scherjon, S.A. (Sico)
- Abstract
Objective: To compare the effect of induction of labour with a policy of expectant monitoring for intrauterine growth restriction near term. Design: Multicentre randomised equivalence trial (the Disproportionate Intrauterine Growth Intervention Trial At Term (DIGITAT)). Setting: Eight academic and 44 non-academic hospitals in the Netherlands between November 2004 and November 2008. Participants: Pregnant women who had a singleton pregnancy beyond 36+0 weeks' ge
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- 2011
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27. Obstetrical outcome valuations by patients, professionals, and laypersons: differences within and between groups using three valuation methods
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Bijlenga, D, Birnie, Erwin, Mol, BWJ (Ben), Bonsel, Gouke, Bijlenga, D, Birnie, Erwin, Mol, BWJ (Ben), and Bonsel, Gouke
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- 2011
28. Maternal health-related quality of life after induction of labor or expectant monitoring in pregnancy complicated by intrauterine growth retardation beyond 36 weeks
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Bijlenga, D, Boers, KE, Birnie, Erwin, Mol, BWJ (Ben), Vijgen, SCM, van der Post, JAM, de Groot, CJM, Rijnders, RJP, Pernet, PJ, Roumen, FJ, Stigter, RH, Delemarre, FMC, Bremer, HA, Porath, MM, Scherjon, SA, Bonsel, Gouke, Bijlenga, D, Boers, KE, Birnie, Erwin, Mol, BWJ (Ben), Vijgen, SCM, van der Post, JAM, de Groot, CJM, Rijnders, RJP, Pernet, PJ, Roumen, FJ, Stigter, RH, Delemarre, FMC, Bremer, HA, Porath, MM, Scherjon, SA, and Bonsel, Gouke
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- 2011
29. Induction of labour versus expectant management in women with preterm prelabour rupture of membranes between 34 and 37 weeks (the PPROMEXIL-trial).
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Ham, D.P. van der, Nijhuis, J.G., Mol, B.W., Beek, J.J. van, Opmeer, B.C., Bijlenga, D., Groenewout, M., Arabin, B., Bloemenkamp, K.W., Wijngaarden, W.J. van, Wouters, M.G.A.J., Pernet, P.J., Porath, M.M., Molkenboer, J.F., Derks, J.B., Kars, M.M., Scheepers, H.C.J., Weinans, M.J., Woiski, M.D., Wildschut, H.I.J., Willekes, C., Ham, D.P. van der, Nijhuis, J.G., Mol, B.W., Beek, J.J. van, Opmeer, B.C., Bijlenga, D., Groenewout, M., Arabin, B., Bloemenkamp, K.W., Wijngaarden, W.J. van, Wouters, M.G.A.J., Pernet, P.J., Porath, M.M., Molkenboer, J.F., Derks, J.B., Kars, M.M., Scheepers, H.C.J., Weinans, M.J., Woiski, M.D., Wildschut, H.I.J., and Willekes, C.
- Abstract
Contains fulltext : 53155.pdf ( ) (Open Access), BACKGROUND: Preterm prelabour rupture of the membranes (PPROM) is an important clinical problem and a dilemma for the gynaecologist. On the one hand, awaiting spontaneous labour increases the probability of infectious disease for both mother and child, whereas on the other hand induction of labour leads to preterm birth with an increase in neonatal morbidity (e.g., respiratory distress syndrome (RDS)) and a possible rise in the number of instrumental deliveries. METHODS/DESIGN: We aim to determine the effectiveness and cost-effectiveness of immediate delivery after PPROM in near term gestation compared to expectant management. Pregnant women with preterm prelabour rupture of the membranes at a gestational age from 34+0 weeks until 37+0 weeks will be included in a multicentre prospective randomised controlled trial. We will compare early delivery with expectant monitoring.The primary outcome of this study is neonatal sepsis. Secondary outcome measures are maternal morbidity (chorioamnionitis, puerperal sepsis) and neonatal disease, instrumental delivery rate, maternal quality of life, maternal preferences and costs. We anticipate that a reduction of neonatal infection from 7.5% to 2.5% after induction will outweigh an increase in RDS and additional costs due to admission of the child due to prematurity. Under these assumptions, we aim to randomly allocate 520 women to two groups of 260 women each. Analysis will be by intention to treat. Additionally a cost-effectiveness analysis will be performed to evaluate if the cost related to early delivery will outweigh those of expectant management. Long term outcomes will be evaluated using modelling. DISCUSSION: This trial will provide evidence as to whether induction of labour after preterm prelabour rupture of membranes is an effective and cost-effective strategy to reduce the risk of neonatal sepsis. CONTROLLED CLINICAL TRIAL REGISTER: ISRCTN29313500.
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- 2007
30. Induction of labour versus expectant monitoring in women with pregnancy induced hypertension or mild preeclampsia at term: the HYPITAT trial.
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Koopmans, C.M., Bijlenga, D., Aarnoudse, J.G., Beek, E. van, Bekedam, D.J., Berg, P.P. van den, Burggraaff, J.M., Birnie, E., Bloemenkamp, K.W., Drogtrop, A.P., Franx, A., Groot, C.J. de, Huisjes, A.J.M., Kwee, A., Cessie, S. le, Loon, A.J. van, Mol, B.W., Post, J.A. van der, Roumen, F.J.M.E., Scheepers, H.C.J., Spaanderman, M.E.A., Stigter, R.H., Willekes, C., Pampus, M.G. van, Koopmans, C.M., Bijlenga, D., Aarnoudse, J.G., Beek, E. van, Bekedam, D.J., Berg, P.P. van den, Burggraaff, J.M., Birnie, E., Bloemenkamp, K.W., Drogtrop, A.P., Franx, A., Groot, C.J. de, Huisjes, A.J.M., Kwee, A., Cessie, S. le, Loon, A.J. van, Mol, B.W., Post, J.A. van der, Roumen, F.J.M.E., Scheepers, H.C.J., Spaanderman, M.E.A., Stigter, R.H., Willekes, C., and Pampus, M.G. van
- Abstract
Contains fulltext : 53183.pdf ( ) (Open Access), BACKGROUND: Hypertensive disorders, i.e. pregnancy induced hypertension and preeclampsia, complicate 10 to 15% of all pregnancies at term and are a major cause of maternal and perinatal morbidity and mortality. The only causal treatment is delivery. In case of preterm pregnancies conservative management is advocated if the risks for mother and child remain acceptable. In contrast, there is no consensus on how to manage mild hypertensive disease in pregnancies at term. Induction of labour might prevent maternal and neonatal complications at the expense of increased instrumental vaginal delivery rates and caesarean section rates. METHODS/DESIGN: Women with a pregnancy complicated by pregnancy induced hypertension or mild preeclampsia at a gestational age between 36+0 and 41+0 weeks will be asked to participate in a multi-centre randomised controlled trial. Women will be randomised to either induction of labour or expectant management for spontaneous delivery. The primary outcome of this study is severe maternal morbidity, which can be complicated by maternal mortality in rare cases. Secondary outcome measures are neonatal mortality and morbidity, caesarean and vaginal instrumental delivery rates, maternal quality of life and costs. Analysis will be by intention to treat. In total, 720 pregnant women have to be randomised to show a reduction in severe maternal complications of hypertensive disease from 12 to 6%. DISCUSSION: This trial will provide evidence as to whether or not induction of labour in women with pregnancy induced hypertension or mild preeclampsia (nearly) at term is an effective treatment to prevent severe maternal complications. TRIAL REGISTRATION: The protocol is registered in the clinical trial register number ISRCTN08132825.
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- 2007
31. Disproportionate Intrauterine Growth Intervention Trial At Term: DIGITAT
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Boers, K.E. (Kim), Bijlenga, D. (Denise), Mol, B.W.J. (Ben), LeCessie, S. (Saskia), Birnie, E. (Erwin), Pampus, M.G. (Maria) van, Stigter, R.H. (Rob), Bloemenkamp, K.W.M. (Kitty), Meir, C.A. (Claudia) van, Post, J.A.M. (Joris) van der, Bekedam, D.J. (Dick), Ribbert, L.S.M. (Lucy), Drogtrop, A.P. (Addie), Salm, P.C.M. (Paulien) van der, Huisjes, A.J.M. (Anjoke), Willekes, C. (Christine), Roumen, F.J.M.E. (Frans), Scheepers, H.C.J. (Hubertina), Boer, K. (Karin) de, Duvekot, J.J. (Hans), Thornton, J.G. (Jim), Scherjon, S.A. (Sicco), Boers, K.E. (Kim), Bijlenga, D. (Denise), Mol, B.W.J. (Ben), LeCessie, S. (Saskia), Birnie, E. (Erwin), Pampus, M.G. (Maria) van, Stigter, R.H. (Rob), Bloemenkamp, K.W.M. (Kitty), Meir, C.A. (Claudia) van, Post, J.A.M. (Joris) van der, Bekedam, D.J. (Dick), Ribbert, L.S.M. (Lucy), Drogtrop, A.P. (Addie), Salm, P.C.M. (Paulien) van der, Huisjes, A.J.M. (Anjoke), Willekes, C. (Christine), Roumen, F.J.M.E. (Frans), Scheepers, H.C.J. (Hubertina), Boer, K. (Karin) de, Duvekot, J.J. (Hans), Thornton, J.G. (Jim), and Scherjon, S.A. (Sicco)
- Abstract
Background: Around 80% of intrauterine growth restricted (IUGR) infants are born at term. They have an increase in perinatal mortality and morbidity including behavioral problems, minor developmental delay and spastic cerebral palsy. Management is controversial, in particular the decision whether to induce labour or await spontaneous delivery with strict fetal and maternal surveillance. We propose a randomised trial to compare effectiveness, costs and maternal quality of life for induction of labour versus expectant management in women with a suspected IUGR fetus at term. Methods/design: The proposed trial is a multi-centre randomised study in pregnant women who are suspected on clinical grounds of having an IUGR child at a gestational age between 36+0 and 41+0 weeks. After informed consent women will be randomly allocated to either induction of labour or expectant management with maternal and fetal monitoring. Randomisation will be web-based. The primary outcome measure will be a composite neonatal morbidity and mortality. Secondary outcomes will be severe maternal morbidity, maternal quality of life and costs. Moreover, we aim to assess neurodevelopmental and neurobehavioral outcome at two years as assessed by a postal enquiry (Child Behavioral Check List-CBCL and Ages and Stages Questionnaire-ASQ). Analysis will be by intention to treat. Quality of life analysis and a preference study will also be performed in the same study population. Health technology assessment with an economic analysis is part of this so called Digitat trial (Disproportionate Intrauterine Growth Intervention Trial At Term). The study aims to include 325 patients per arm. Discussion: This trial will provide evidence for which strategy is superior in terms of neonatal and maternal morbidity and mortality, costs and maternal quality of life aspects. This will be the first randomised trial for IUGR at term.
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- 2007
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32. Induction of labour versus expectant management in women with preterm prelabour rupture of membranes between 34 and 37 weeks (the PPROMEXIL-trial)
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Ham, D.P. (David) van der, Nijhuis, J.G. (Jan), Mol, B.W.J. (Ben), Beek, J.J. (Hans) van, Opmeer, B.C. (Brent), Bijlenga, D. (Denise), Groenewout, M. (Mariette), Arabin, B. (Birgit), Bloemenkamp, K.W.M. (Kitty), Wijngaarden, W.J. (Wim) van, Wouters, M.G.A.J. (Maurice), Pernet, P.J.M. (Paula), Porath, M. (Martina), Molkenboer, J.F.M. (Jan), Derks, J.B. (Jan), Kars, M.M. (Michael M.), Scheepers, H.C.J. (Hubertina), Weinans, M.J.N. (Martin), Woiski, M.D. (Mallory), Wildschut, H.I.J. (Hajo), Willekes, C. (Christine), Ham, D.P. (David) van der, Nijhuis, J.G. (Jan), Mol, B.W.J. (Ben), Beek, J.J. (Hans) van, Opmeer, B.C. (Brent), Bijlenga, D. (Denise), Groenewout, M. (Mariette), Arabin, B. (Birgit), Bloemenkamp, K.W.M. (Kitty), Wijngaarden, W.J. (Wim) van, Wouters, M.G.A.J. (Maurice), Pernet, P.J.M. (Paula), Porath, M. (Martina), Molkenboer, J.F.M. (Jan), Derks, J.B. (Jan), Kars, M.M. (Michael M.), Scheepers, H.C.J. (Hubertina), Weinans, M.J.N. (Martin), Woiski, M.D. (Mallory), Wildschut, H.I.J. (Hajo), and Willekes, C. (Christine)
- Abstract
Background: Preterm prelabour rupture of the membranes (PPROM) is an important clinical problem and a dilemma for the gynaecologist. On the one hand, awaiting spontaneous labour increases the probability of infectious disease for both mother and child, whereas on the other hand induction of labour leads to preterm birth with an increase in neonatal morbidity (e.g., respiratory distress syndrome (RDS)) and a possible rise in the number of instrumental deliveries. Methods/Design: We aim to determine the effectiveness and cost-effectiveness of immediate delivery after PPROM in near term gestation compared to expectant management. Pregnant women with preterm prelabour rupture of the membranes at a gestational age from 34+0 weeks until 37+0 weeks will be included in a multicentre prospective randomised controlled trial. We will compare early delivery with expectant monitoring. The primary outcome of this study is neonatal sepsis. Secondary outcome measures are maternal morbidity (chorioamnionitis, puerperal sepsis) and neonatal disease, instrumental delivery rate, maternal quality of life, maternal preferences and costs. We anticipate that a reduction of neonatal infection from 7.5% to 2.5% after induction will outweigh an incre
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- 2007
- Full Text
- View/download PDF
33. When outcome is a balance: Methods to measure combined utility for the choice between induction of labour and expectant management in mild risk pregnancy at term
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Bijlenga, D. (Denise), Birnie, E. (Erwin), Mol, B.W.J. (Ben), Bonsel, G.J. (Gouke), Bijlenga, D. (Denise), Birnie, E. (Erwin), Mol, B.W.J. (Ben), and Bonsel, G.J. (Gouke)
- Abstract
Background: When the primary and secondary outcomes of clinical studies yield ambiguous or conflicting recommendations, preference or valuation studies may help to overcome the decision problem. The present preference study is attached to two clinical studies (DIGTAT, ISRCT10363217; HYPITAT, ISRCT08132825) that evaluate induction of labour versus expectant management in term pregnancies with a mild risk profile. The purpose of the present study is to compare four methods of valuation/preference measurement. Meth
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- 2007
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34. Disproportionate Intrauterine Growth Intervention Trial At Term: DIGITAT.
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Boers, K.E., Bijlenga, D., Mol, B.W., LeCessie, S., Birnie, E., Pampus, M.G. van, Stigter, R.H., Bloemenkamp, K.W., Meir, C.A. van, Post, J.A. van der, Bekedam, D.J., Ribbert, L.S., Drogtrop, A.P., Salm, P.C. van der, Huisjes, A.J.M., Willekes, C., Roumen, F.J.M.E., Scheepers, H.C.J., Boer, K., Duvekot, J.J., Thornton, J.G., Scherjon, S.A., Boers, K.E., Bijlenga, D., Mol, B.W., LeCessie, S., Birnie, E., Pampus, M.G. van, Stigter, R.H., Bloemenkamp, K.W., Meir, C.A. van, Post, J.A. van der, Bekedam, D.J., Ribbert, L.S., Drogtrop, A.P., Salm, P.C. van der, Huisjes, A.J.M., Willekes, C., Roumen, F.J.M.E., Scheepers, H.C.J., Boer, K., Duvekot, J.J., Thornton, J.G., and Scherjon, S.A.
- Abstract
Contains fulltext : 65628.pdf ( ) (Open Access), BACKGROUND: Around 80% of intrauterine growth restricted (IUGR) infants are born at term. They have an increase in perinatal mortality and morbidity including behavioral problems, minor developmental delay and spastic cerebral palsy. Management is controversial, in particular the decision whether to induce labour or await spontaneous delivery with strict fetal and maternal surveillance. We propose a randomised trial to compare effectiveness, costs and maternal quality of life for induction of labour versus expectant management in women with a suspected IUGR fetus at term. METHODS/DESIGN: The proposed trial is a multi-centre randomised study in pregnant women who are suspected on clinical grounds of having an IUGR child at a gestational age between 36+0 and 41+0 weeks. After informed consent women will be randomly allocated to either induction of labour or expectant management with maternal and fetal monitoring. Randomisation will be web-based. The primary outcome measure will be a composite neonatal morbidity and mortality. Secondary outcomes will be severe maternal morbidity, maternal quality of life and costs. Moreover, we aim to assess neurodevelopmental and neurobehavioral outcome at two years as assessed by a postal enquiry (Child Behavioral Check List-CBCL and Ages and Stages Questionnaire-ASQ). Analysis will be by intention to treat. Quality of life analysis and a preference study will also be performed in the same study population. Health technology assessment with an economic analysis is part of this so called Digitat trial (Disproportionate Intrauterine Growth Intervention Trial At Term). The study aims to include 325 patients per arm. DISCUSSION: This trial will provide evidence for which strategy is superior in terms of neonatal and maternal morbidity and mortality, costs and maternal quality of life aspects. This will be the first randomised trial for IUGR at term. TRIAL REGISTRATION: Dutch Trial Register and ISRCTN-Register: ISRCTN10363217.
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- 2007
35. Induction of labour versus expectant management in women with preterm prelabour rupture of membranes between 34 and 37 weeks (the PPROMEXIL-trial)
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van der Ham, DP, Nijhuis, JG, Mol, BWJ (Ben), van Beek, JJ, Opmeer, BC, Bijlenga, D, Groenewout, M (Mariette), Arabin, B, Bloemenkamp, KWM, van Wijngaarden, WJ, Wouters, MGAJ, Pernet, PJM, Porath, MM, Molkenboer, JFM, Derks, JB, Kars, MM, Scheepers, HCJ, Weinans, MJN, Woiski, MD, Wildschut, Hajo, Willekes, C, van der Ham, DP, Nijhuis, JG, Mol, BWJ (Ben), van Beek, JJ, Opmeer, BC, Bijlenga, D, Groenewout, M (Mariette), Arabin, B, Bloemenkamp, KWM, van Wijngaarden, WJ, Wouters, MGAJ, Pernet, PJM, Porath, MM, Molkenboer, JFM, Derks, JB, Kars, MM, Scheepers, HCJ, Weinans, MJN, Woiski, MD, Wildschut, Hajo, and Willekes, C
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- 2007
36. When outcome is a balance: methods to measure combined utility for the choice between induction of labour and expectant management in mild risk pregnancy at term
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Bijlenga, D, Birnie, Erwin, Mol, BWJ (Ben), Bonsel, Gouke, Bijlenga, D, Birnie, Erwin, Mol, BWJ (Ben), and Bonsel, Gouke
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- 2007
37. Disproportionate intrauterine growth intervention trial at term: DIGITAT
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Boers, KE, Bijlenga, D, Mol, BWJ (Ben), le Cessie, S, Birnie, Erwin, van Pampus, MG, Stigter, RH, Bloemenkamp, KWM, van Meir, CA, Van der Post, JAM, Bekedam, DJ, Ribbert, LSM, Drogtrop, AP, van der Salm, PCM, Huisjes, AJM, Willekes, C, Roumen, FJME, Scheepers, HCJ, de Boer, K, Duvekot, JJ, Thornton, JG, Scherjon, SA, Boers, KE, Bijlenga, D, Mol, BWJ (Ben), le Cessie, S, Birnie, Erwin, van Pampus, MG, Stigter, RH, Bloemenkamp, KWM, van Meir, CA, Van der Post, JAM, Bekedam, DJ, Ribbert, LSM, Drogtrop, AP, van der Salm, PCM, Huisjes, AJM, Willekes, C, Roumen, FJME, Scheepers, HCJ, de Boer, K, Duvekot, JJ, Thornton, JG, and Scherjon, SA
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- 2007
38. Gestational Hypertension or Preeclampsia at Term (HYPITAT Trial)
- Author
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Vijgen, S.M.C., primary, Koopmans, C.M., additional, Opmeer, B.C., additional, Groen, H., additional, Bijlenga, D., additional, Aarnoudse, J.G., additional, Bekedam, D.J., additional, van den Berg, P.P., additional, de Boer, K., additional, Burggraaff, J.M., additional, Bloemenkamp, K.W.M., additional, Drogtrop, A.P., additional, Franx, A., additional, de Groot, C.J.M., additional, Huisjes, A.J.M., additional, Kwee, A., additional, van Loon, A.J., additional, Lub, A., additional, Papatsonis, D.N.M., additional, van der Post, J.A.M., additional, Roumen, F.J.M.E., additional, Scheepers, H.C.J., additional, Stigter, R.H., additional, Willekes, C., additional, Mol, B.W.J., additional, and Van Pampus, M.G., additional
- Published
- 2011
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39. Induction of Labor Versus Expectant Monitoring for Gestational Hypertension or Mild Preeclampsia After 36 Weeks of Gestation (HYPITAT): a Multicenter, Open-label Randomized Controlled Trial
- Author
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Koopmans, C.M., primary, Bijlenga, D., additional, Groen, H., additional, Vijgen, S.M., additional, Aarnoudse, J.G., additional, Bekedam, D.J., additional, van den Berg, P.P., additional, de Boer, K., additional, Burggraaff, J.M., additional, Bloemenkamp, K.W., additional, Drogtrop, A.P., additional, Franx, A., additional, de Groot, C.J., additional, Huisjes, A.J., additional, Kwee, A., additional, van Loon, A.J., additional, Lub, A., additional, Papatsonis, D.N., additional, van der Post, J.A., additional, Roumen, F.J., additional, Scheepers, H.C., additional, Willekes, C., additional, Mol, B.W., additional, and van Pampus, M.G., additional
- Published
- 2010
- Full Text
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40. WP1 COMPARISON OF A DIRECT AND AN INDIRECT METHOD TO DERIVE WILLINGNESS TO PAY FOR COMPLEX HEALTH STATES IN OBSTETRICS
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Bijlenga, D, primary, Bonsel, GJ, additional, and Birnie, E, additional
- Published
- 2009
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41. PCV56 AN ECONOMIC ANALYSIS OF INDUCTION OF LABOR AND EXPECTANT MANAGEMENT INWOMEN WITH PREGNANCYINDUCED HYPERTENSION OR PREECLAMPSIA AT TERM (HYPITAT TRIAL)
- Author
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Vijgen, SM, primary, Opmeer, BC, additional, Mol, B, additional, Bijlenga, D, additional, Burggraaff, JM, additional, van Loon, AJ, additional, Huisjes, AJ, additional, Roumen, FJ, additional, Papatsonis, DN, additional, and van Pampus, MG, additional
- Published
- 2008
- Full Text
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42. Maternal health-related quality of life after induction of labor or expectant monitoring in pregnancy complicated by intrauterine growth retardation beyond 36 weeks.
- Author
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Bijlenga D, Boers KE, Birnie E, Mol BW, Vijgen SC, Van der Post JA, De Groot CJ, Rijnders RJ, Pernet PJ, Roumen FJ, Stigter RH, Delemarre FM, Bremer HA, Porath M, Scherjon SA, Bonsel GJ, Bijlenga, Denise, Boers, Kim E, Birnie, Erwin, and Mol, Ben-Willem J
- Abstract
Objective: Pregnancies complicated by intrauterine growth retardation (IUGR) beyond 36 weeks of gestation are at increased risk of neonatal morbidity and mortality. Optimal treatment in IUGR at term is highly debated. Results from the multicenter DIGITAT (Disproportionate Intrauterine Growth Intervention Trial At Term) trial show that induction of labor and expectant monitoring result in equal neonatal and maternal outcomes for comparable cesarean section rates. We report the maternal health-related quality of life (HR-QoL) that was measured alongside the trial at several points in time.Methods: Both randomized and non-randomized women were asked to participate in the HR-QoL study. Women were asked to fill out written validated questionnaires, covering background characteristics, condition-specific issues and the Short Form (SF-36), European Quality of Life (EuroQoL 6D3L), Hospital Anxiety and Depression scale (HADS), and Symptom Check List (SCL-90) at baseline, 6 weeks postpartum and 6 months postpartum. We compared the difference scores of all summary measures between the two management strategies by ANOVA. A repeated measures multivariate mixed model was defined to assess the effect of the management strategies on the physical (PCS) and mental (MCS) components of the SF-36. Analysis was by intention to treat.Results: We analyzed data of 361 randomized and 198 non-randomized patients. There were no clinically relevant differences between the treatments at 6 weeks or 6 months postpartum on any summary measures; e.g., on the SF-36 (PCS: P = .09; MCS: P = .48). The PCS and the MCS were below norm values at inclusion. The PCS improved over time but stayed below norm values at 6 months, while the MCS did not improve.Conclusion: In pregnancies complicated by IUGR beyond 36 weeks, induction of labor does not affect the long-term maternal quality of life. [ABSTRACT FROM AUTHOR]- Published
- 2011
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43. The rhythm of adult ADHD: On the relationships between ADHD, sleep and aging
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Wynchank, D.S., Penninx, B.W.J.H., Beekman, A.T.F., Kooij, J.J.S., Bijlenga, D., Penninx, Brenda, Beekman, Aartjan, Kooij, Sandra, APH - Mental Health, and Psychiatry
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Metabolic Syndrome ,Insomnia ,Adult ADHD ,LTL - Published
- 2018
44. ADHD IN ADULTS: seasons, stress, sleep and societal impact
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Vogel, S.W.N., Beekman, A.T.F., Kooij, J.J.S., and Bijlenga, D.
- Published
- 2017
45. Lifestyle in adult ADHD: From a Picasso point of view
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Bron, T.I., Beekman, A.T.F., Kooij, J.J.S., and Bijlenga, D.
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adult ADHD ,depression ,driving ,sleep disorders ,staging ,smoking ,cognitive functioning - Published
- 2017
46. Sleep Problems in Adults With ADHD: Prevalences and Their Relationship With Psychiatric Comorbidity.
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van der Ham M, Bijlenga D, Böhmer M, Beekman ATF, and Kooij S
- Abstract
Background: Sleep problems are common in adults with ADHD and may be bidirectionally associated with ADHD severity and other psychiatric symptoms. We investigated the prevalence of positive screenings for various sleep disorders, and their association with psychiatric comorbidities in a large sample of adults with ADHD from a specialized outpatient clinic., Methods: We included data of 3,691 adult patients diagnosed with ADHD, who had filled out a screener for sleep disorders (Holland Sleep Disorders Questionnaire (HSDQ)) as part of routine diagnostic assessment. The HSDQ screens for the sleep disorders insomnia, parasomnia, hypersomnia, circadian rhythm sleep disorders (CRSD), restless legs syndrome (RLS)/periodic limb movement disorder (PLMD), and sleep-related breathing disorders (SBD). As delayed sleep phase syndrome (DSPS) is very frequent in ADHD, we additionally screened for DSPS. Psychiatric comorbidities were diagnosed through clinical assessment and the Mini International Neuropsychiatric Interview (M.I.N.I.) Plus, which assesses 26 psychiatric disorders following the classification of the DSM-5. All data were retrieved from the electronic patient files., Results: Mean age was 35.4 and 49.4% of the patients were female. About 60% of the adults with ADHD screened positive for any sleep disorder. Highest prevalences were found for symptoms of DSPS (36%), insomnia (30%), and RLS/PLMD (29%). Sleep problems in adults with ADHD were associated with comorbid depression, anxiety, substance use disorder, personality disorder, and post-traumatic stress disorder., Conclusion: Adults with ADHD often report sleep problems, which are associated with specific psychiatric comorbidities. Systematic screening for sleep disorders in adult patients with ADHD can contribute to a better understanding of their complaints and may aid improved and integrated treatment for the sleep and psychiatric problems., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Published
- 2024
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47. Effects of Chronotherapeutic Interventions in Adults With ADHD and Delayed Sleep Phase Syndrome (DSPS) on Regulation of Appetite and Glucose Metabolism.
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van Andel E, Vogel SWN, Bijlenga D, Kalsbeek A, Beekman ATF, and Kooij JJS
- Abstract
Background: ADHD is highly comorbid with Delayed Sleep Phase Syndrome (DSPS). Both are associated with obesity and diabetes, which can be caused by long-term dysregulations of appetite and glucose metabolism. This study explores hormones involved in these processes and the effects of chronotherapeutic interventions in a small sample of adults with ADHD and DSPS. Methods: Exploratory, secondary analysis of data from the PhASE study, a three-armed randomized clinical trial, are presented, including 37 adults (18-53 years) with ADHD and DSPS receiving three weeks of 0.5 mg/day (1) placebo, (2) melatonin, or (3) melatonin plus 30 minutes of bright light therapy (BLT). Leptin (appetite-suppressing), ghrelin (appetite-stimulating), insulin, insulin-like growth factor-1 (IGF-1), and glucose were measured from blood collected at 08:00 hours. Salivary cortisol was collected during the first 30 minutes after awakening and self-reported appetite was assessed. Results: Baseline leptin and IGF-1 levels were higher than reference ranges, and ghrelin and cortisol levels were lower, while insulin and glucose were normal. Melatonin treatment decreased leptin and insulin. Other outcomes remained unchanged and melatonin + BLT had no effects. Conclusion: Due to the small sample size and exploratory nature of the study, results should be interpreted with caution. Overall, these results show no strong indications for dysregulation of appetite and glucose metabolism to suggest high risk of obesity and diabetes in this small sample of adults with ADHD and DSPS. However, baseline appetite was suppressed, likely because measurements took place in the early morning which could be considered the biological night for this study population. Melatonin treatment seemed to cause subtle changes in appetite-regulating hormones suggesting increased appetite. Chronotherapeutic treatment may affect appetite-regulating hormones by advancing the biological rhythm and/or altering eating behaviors, but this remains to be investigated in larger samples using detailed food diaries., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Published
- 2024
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48. Recent insights into the pathophysiology of narcolepsy type 1.
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Vringer M, Zhou J, Gool JK, Bijlenga D, Lammers GJ, Fronczek R, and Schinkelshoek MS
- Abstract
Narcolepsy type 1 (NT1) is a sleep-wake disorder in which people typically experience excessive daytime sleepiness, cataplexy and other sleep-wake disturbances impairing daily life activities. NT1 symptoms are due to hypocretin deficiency. The cause for the observed hypocretin deficiency remains unclear, even though the most likely hypothesis is that this is due to an auto-immune process. The search for autoantibodies and autoreactive T-cells has not yet produced conclusive evidence for or against the auto-immune hypothesis. Other mechanisms, such as reduced corticotrophin-releasing hormone production in the paraventricular nucleus have recently been suggested. There is no reversive treatment, and the therapeutic approach is symptomatic. Early diagnosis and appropriate NT1 treatment is essential, especially in children to prevent impaired cognitive, emotional and social development. Hypocretin receptor agonists have been designed to replace the attenuated hypocretin signalling. Pre-clinical and clinical trials have shown encouraging initial results. A better understanding of NT1 pathophysiology may contribute to faster diagnosis or treatments, which may cure or prevent it., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2024
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49. "Hypertension in Pregnancy Intervention Trial At Term" and "Disproportionate Intrauterine Growth Intervention Trial At Term" Studies.
- Author
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van Pampus MG, van der Post JAM, Verhoeven CJ, Koopmans CM, Langenveld J, Broekhuijsen K, de Sonnaville CMW, van der Tuuk K, Boers K, Groen H, Vijgen S, Bijlenga D, Scherjon S, and Mol BW
- Subjects
- Humans, Pregnancy, Female, Labor, Induced methods, Infant, Newborn, Fetal Growth Retardation prevention & control, Hypertension, Pregnancy-Induced prevention & control, Hypertension, Pregnancy-Induced therapy
- Abstract
In 2003, in the context of a national research funding program in which obstetric research was prioritized, several perinatal centers took the initiative to jointly submit a number of applications to the subsidy programs of Effectiveness Research and Prevention of ZonMw. This has led to the funding of the Obstetric Consortium with several projects, including the "Hypertension in Pregnancy Intervention Trial At Term" and the "Disproportionate Intrauterine Growth Intervention Trial At Term" studies. The studies showed that induction of labor for hypertension and growth restriction at term was the appropriate management. Subsequent implementation improved maternal and perinatal outcomes., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2024
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50. Skin temperature as a predictor of on-the-road driving performance in people with central disorders of hypersomnolence.
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Vael VEC, Bijlenga D, Schinkelshoek MS, van der Sluiszen NNJJM, Remmerswaal A, Overeem S, Ramaekers JG, Vermeeren A, Lammers GJ, and Fronczek R
- Subjects
- Humans, Male, Female, Adult, Middle Aged, Psychomotor Performance physiology, Narcolepsy physiopathology, Automobile Driving, Skin Temperature physiology, Disorders of Excessive Somnolence physiopathology, Disorders of Excessive Somnolence etiology
- Abstract
Excessive daytime sleepiness is the core symptom of central disorders of hypersomnolence (CDH) and can directly impair driving performance. Sleepiness is reflected in relative alterations in distal and proximal skin temperature. Therefore, we examined the predictive value of skin temperature on driving performance. Distal and proximal skin temperature and their gradient (DPG) were continuously measured in 44 participants with narcolepsy type 1, narcolepsy type 2 or idiopathic hypersomnia during a standardised 1-h driving test. Driving performance was defined as the standard deviation of lateral position (SDLP) per 5 km segment (equivalent to 3 min of driving). Distal and proximal skin temperature and DPG measurements were averaged over each segment and changes over segments were calculated. Mixed-effect model analyses showed a strong, quadratic association between proximal skin temperature and SDLP (p < 0.001) and a linear association between DPG and SDLP (p < 0.021). Proximal skin temperature changes over 3 to 15 min were predictive for SDLP. Moreover, SDLP increased over time (0.34 cm/segment, p < 0.001) and was higher in men than in women (3.50 cm, p = 0.012). We conclude that proximal skin temperature is a promising predictor for real-time assessment of driving performance in people with CDH., (© 2023 The Authors. Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society.)
- Published
- 2024
- Full Text
- View/download PDF
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