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302 results on '"Bignotti, Eliana"'

2. Biological and clinical impact of membrane EGFR expression in a subgroup of OC patients from the phase IV ovarian cancer MITO-16A/MANGO-OV2A trial

Author

Forlani, Luca, De Cecco, Loris, Simeon, Vittorio, Paolini, Biagio, Bagnoli, Marina, Cecere, Sabrina Chiara, Spina, Anna, Citeroni, Eleonora, Bignotti, Eliana, Lorusso, Domenica, Arenare, Laura, Russo, Daniela, De Angelis, Carmine, Ardighieri, Laura, Scognamiglio, Giosuè, Del Sesto, Michele, Tognon, Germana, Califano, Daniela, Schettino, Clorinda, Chiodini, Paolo, Perrone, Francesco, Mezzanzanica, Delia, Pignata, Sandro, and Tomassetti, Antonella

Published
2023
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5. Integrated mutational landscape analysis of uterine leiomyosarcomas

Author

Choi, Jungmin, Manzano, Aranzazu, Dong, Weilai, Bellone, Stefania, Bonazzoli, Elena, Zammataro, Luca, Yao, Xiaotong, Deshpande, Aditya, Zaidi, Samir, Guglielmi, Adele, Gnutti, Barbara, Nagarkatti, Nupur, Tymon-Rosario, Joan R., Harold, Justin, Mauricio, Dennis, Zeybek, Burak, Menderes, Gulden, Altwerger, Gary, Jeong, Kyungjo, Zhao, Siming, Buza, Natalia, Hui, Pei, Ravaggi, Antonella, Bignotti, Eliana, Romani, Chiara, Todeschini, Paola, Zanotti, Laura, Odicino, Franco, Pecorelli, Sergio, Ardighieri, Laura, Bilguvar, Kaya, Quick, Charles M., Silasi, Dan-Arin, Huang, Gloria S., Andikyan, Vaagn, Clark, Mitchell, Ratner, Elena, Azodi, Masoud, Imielinski, Marcin, Schwartz, Peter E., Alexandrov, Ludmil B., Lifton, Richard P., Schlessinger, Joseph, and Santin, Alessandro D.

Published
2021

6. Integrated mutational landscape analysis of poorly differentiated high-grade neuroendocrine carcinoma of the uterine cervix

Author

Bellone, Stefania, primary, Jeong, Kyungjo, additional, Halle, Mari Kyllesø, additional, Krakstad, Camilla, additional, McNamara, Blair, additional, Greenman, Michelle, additional, Mutlu, Levent, additional, Demirkiran, Cem, additional, Hartwich, Tobias Max Philipp, additional, Yang-Hartwich, Yang, additional, Zipponi, Margherita, additional, Buza, Natalia, additional, Hui, Pei, additional, Raspagliesi, Francesco, additional, Lopez, Salvatore, additional, Paolini, Biagio, additional, Milione, Massimo, additional, Perrone, Emanuele, additional, Scambia, Giovanni, additional, Altwerger, Gary, additional, Ravaggi, Antonella, additional, Bignotti, Eliana, additional, Huang, Gloria S., additional, Andikyan, Vaagn, additional, Clark, Mitchell, additional, Ratner, Elena, additional, Azodi, Masoud, additional, Schwartz, Peter E., additional, Quick, Charles M., additional, Angioli, Roberto, additional, Terranova, Corrado, additional, Zaidi, Samir, additional, Nandi, Shuvro, additional, Alexandrov, Ludmil B., additional, Siegel, Eric R., additional, Choi, Jungmin, additional, Schlessinger, Joseph, additional, and Santin, Alessandro D., additional

Published
2024
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7. Whole-exome sequencing of cervical carcinomas identifies activating ERBB2 and PIK3CA mutations as targets for combination therapy

Author

Zammataro, Luca, Lopez, Salvatore, Bellone, Stefania, Pettinella, Francesca, Bonazzoli, Elena, Perrone, Emanuele, Zhao, Siming, Menderes, Gulden, Altwerger, Gary, Han, Chanhee, Zeybek, Burak, Bianchi, Anna, Manzano, Aranzazu, Manara, Paola, Cocco, Emiliano, Buza, Natalia, Hui, Pei, Wong, Serena, Ravaggi, Antonella, Bignotti, Eliana, Romani, Chiara, Todeschini, Paola, Zanotti, Laura, Odicino, Franco, Pecorelli, Sergio, Donzelli, Carla, Ardighieri, Laura, Angioli, Roberto, Raspagliesi, Francesco, Scambia, Giovanni, Choi, Jungmin, Dong, Weilai, Bilguvar, Kaya, Alexandrov, Ludmil B., Silasi, Dan-Arin, Huang, Gloria S., Ratner, Elena, Azodi, Masoud, Schwartz, Peter E., Pirazzoli, Valentina, Stiegler, Amy L., Boggon, Titus J., Lifton, Richard P., Schlessinger, Joseph, and Santin, Alessandro D.

Published
2019

9. Hormone Receptor Expression and Activity for Different Tumour Locations in Patients with Advanced and Recurrent Endometrial Carcinoma.

Author

Luijten, Maartje M. W., van Weelden, Willem Jan, Lalisang, Roy I., Bulten, Johan, Lindemann, Kristina, van Beekhuizen, Heleen J., Trum, Hans, Boll, Dorry, Werner, Henrica M. J., van Lonkhuijzen, Luc R. C. W., Yigit, Refika, Krakstad, Camilla, Witteveen, Petronella O., Galaal, Khadra, van Ginkel, Alexandra A., Bignotti, Eliana, Weinberger, Vit, Sweegers, Sanne, Eriksson, Ane Gerda Z., and Keizer, Diederick M.

Subjects
ABDOMINAL physiology, UTERUS physiology, PROGESTERONE, SEX hormones, LYMPH nodes, BIOPSY, RISK assessment, CANCER relapse, PROGESTERONE receptors, RESEARCH funding, ESTROGEN, DESCRIPTIVE statistics, ENDOMETRIAL tumors, METASTASIS, ESTROGEN receptors, MESSENGER RNA, HORMONE therapy, TUMOR classification, CANCER patient psychology, COMPARATIVE studies, CELL receptors, DISEASE progression, DISEASE risk factors, DISEASE complications
Abstract

Simple Summary: Oestrogen and progesterone are two sex hormones that are important in the development of cancer of the inner lining of the uterus and endometrial cancer (EC). Oestrogen binds to the oestrogen receptor (ER) and progesterone to the progesterone receptor (PR). The presence of these receptors is important because the response to hormonal therapy is higher when the receptors are present. However, as EC grows and spreads throughout the body, ER and PR may be lost. In this study, we found that tumours that have spread to other organs throughout the blood and tumours that have spread in the abdomen have a relatively high presence of ER/PR, while tumours located in the lymph nodes have a lower presence of PR. ER/PR-IHC were not lower in tumours that had previously been treated with radiotherapy. This might influence the application of hormonal therapy in the future. Background: Response to hormonal therapy in advanced and recurrent endometrial cancer (EC) can be predicted by oestrogen and progesterone receptor immunohistochemical (ER/PR-IHC) expression, with response rates of 60% in PR-IHC > 50% cases. ER/PR-IHC can vary by tumour location and is frequently lost with tumour progression. Therefore, we explored the relationship between ER/PR-IHC expression and tumour location in EC. Methods: Pre-treatment tumour biopsies from 6 different sites of 80 cases treated with hormonal therapy were analysed for ER/PR-IHC expression and classified into categories 0–10%, 10–50%, and >50%. The ER pathway activity score (ERPAS) was determined based on mRNA levels of ER-related target genes, reflecting the actual activity of the ER receptor. Results: There was a trend towards lower PR-IHC (33% had PR > 50%) and ERPAS (27% had ERPAS > 15) in lymphogenic metastases compared to other locations (p = 0.074). Hematogenous and intra-abdominal metastases appeared to have high ER/PR-IHC and ERPAS (85% and 89% ER-IHC > 50%; 64% and 78% PR-IHC > 50%; 60% and 71% ERPAS > 15, not significant). Tumour grade and previous radiotherapy did not affect ER/PR-IHC or ERPAS. Conclusions: A trend towards lower PR-IHC and ERPAS was observed in lymphogenic sites. Verification in larger cohorts is needed to confirm these findings, which may have implications for the use of hormonal therapy in the future. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Mutational landscape of primary, metastatic, and recurrent ovarian cancer reveals c-MYC gains as potential target for BET inhibitor

Author

Li, Charles, Bonazzoli, Elena, Bellone, Stefania, Choi, Jungmin, Dong, Weilai, Menderes, Gulden, Altwerger, Gary, Han, Chanhee, Manzano, Aranzazu, Bianchi, Anna, Pettinella, Francesca, Manara, Paola, Lopez, Salvatore, Yadav, Ghanshyam, Riccio, Francesco, Zammataro, Luca, Zeybek, Burak, Yang-Hartwich, Yang, Buza, Natalia, Hui, Pei, Wong, Serena, Ravaggi, Antonella, Bignotti, Eliana, Romani, Chiara, Todeschini, Paola, Zanotti, Laura, Zizioli, Valentina, Odicino, Franco, Pecorelli, Sergio, Ardighieri, Laura, Silasi, Dan-Arin, Litkouhi, Babak, Ratner, Elena, Azodi, Masoud, Huang, Gloria S., Schwartz, Peter E., Lifton, Richard P., Schlessinger, Joseph, and Santin, Alessandro D.

Published
2019

13. Circulating miRNA landscape identifies miR-1246 as promising diagnostic biomarker in high-grade serous ovarian carcinoma: A validation across two independent cohorts

Author

Todeschini, Paola, Salviato, Elisa, Paracchini, Lara, Ferracin, Manuela, Petrillo, Marco, Zanotti, Laura, Tognon, Germana, Gambino, Angela, Calura, Enrica, Caratti, Giulia, Martini, Paolo, Beltrame, Luca, Maragoni, Lorenzo, Gallo, Daniela, Odicino, Franco E., Sartori, Enrico, Scambia, Giovanni, Negrini, Massimo, Ravaggi, Antonella, D'Incalci, Maurizio, Marchini, Sergio, Bignotti, Eliana, and Romualdi, Chiara

Published
2017
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14. Polymerase ε (POLE) ultra-mutation in uterine tumors correlates with T lymphocyte infiltration and increased resistance to platinum-based chemotherapy in vitro

Author

Bellone, Stefania, Bignotti, Eliana, Lonardi, Silvia, Ferrari, Francesca, Centritto, Floriana, Masserdotti, Alice, Pettinella, Francesca, Black, Jonathan, Menderes, Gulden, Altwerger, Gary, Hui, Pei, Lopez, Salvatore, de Haydu, Christopher, Bonazzoli, Elena, Predolini, Federica, Zammataro, Luca, Cocco, Emiliano, Ferrari, Federico, Ravaggi, Antonella, Romani, Chiara, Facchetti, Fabio, Sartori, Enrico, Odicino, Franco E., Silasi, Dan-Arin, Litkouhi, Babak, Ratner, Elena, Azodi, Masoud, Schwartz, Peter E., and Santin, Alessandro D.

Published
2017
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15. Supplemental Material Section S5 from miRNA Landscape in Stage I Epithelial Ovarian Cancer Defines the Histotype Specificities

Author

Calura, Enrica, primary, Fruscio, Robert, primary, Paracchini, Lara, primary, Bignotti, Eliana, primary, Ravaggi, Antonella, primary, Martini, Paolo, primary, Sales, Gabriele, primary, Beltrame, Luca, primary, Clivio, Luca, primary, Ceppi, Lorenzo, primary, Di Marino, Mariacristina, primary, Fuso Nerini, Ilaria, primary, Zanotti, Laura, primary, Cavalieri, Duccio, primary, Cattoretti, Giorgio, primary, Perego, Patrizia, primary, Milani, Rodolfo, primary, Katsaros, Dionyssios, primary, Tognon, Germana, primary, Sartori, Enrico, primary, Pecorelli, Sergio, primary, Mangioni, Costantino, primary, D'Incalci, Maurizio, primary, Romualdi, Chiara, primary, and Marchini, Sergio, primary

Published
2023
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16. Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial–mesenchymal transition

Author

Zhao, Siming, Bellone, Stefania, Lopez, Salvatore, Thakral, Durga, Schwab, Carlton, English, Diana P., Black, Jonathan, Cocco, Emiliano, Choi, Jungmin, Zammataro, Luca, Predolini, Federica, Bonazzoli, Elena, Bi, Mark, Buza, Natalia, Hui, Pei, Wong, Serena, Abu-Khalaf, Maysa, Ravaggi, Antonella, Bignotti, Eliana, Bandiera, Elisabetta, Romani, Chiara, Todeschini, Paola, Tassi, Renata, Zanotti, Laura, Odicino, Franco, Pecorelli, Sergio, Donzelli, Carla, Ardighieri, Laura, Facchetti, Fabio, Falchetti, Marcella, Silasi, Dan-Arin, Ratner, Elena, Azodi, Masoud, Schwartz, Peter E., Mane, Shrikant, Angioli, Roberto, Terranova, Corrado, Quick, Charles Matthew, Edraki, Babak, Bilgüvar, Kaya, Lee, Moses, Choi, Murim, Stiegler, Amy L., Boggon, Titus J., Schlessinger, Joseph, Lifton, Richard P., and Santin, Alessandro D.

Published
2016

17. Integrated Biomarker Analysis Reveals L1CAM as a Potential Stratification Marker for No Specific Molecular Profile High-Risk Endometrial Carcinoma

Author

Ravaggi, Antonella, primary, Capoferri, Davide, additional, Ardighieri, Laura, additional, Ghini, Iacopo, additional, Ferrari, Federico, additional, Romani, Chiara, additional, Bugatti, Mattia, additional, Zanotti, Laura, additional, Vrede, Stephanie, additional, Tognon, Germana, additional, Pijnenborg, Johanna M. A., additional, Sartori, Enrico, additional, Calza, Stefano, additional, Bignotti, Eliana, additional, and Odicino, Franco, additional

Published
2022
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18. L1CAM expression as a predictor of platinum response in high‐risk endometrial carcinoma

Author

Romani, Chiara, primary, Capoferri, Davide, additional, Reijnen, Casper, additional, Lonardi, Silvia, additional, Ravaggi, Antonella, additional, Ratti, Martina, additional, Bugatti, Mattia, additional, Zanotti, Laura, additional, Tognon, Germana, additional, Sartori, Enrico, additional, Odicino, Franco, additional, Calza, Stefano, additional, Pijnenborg, Johanna M. A., additional, and Bignotti, Eliana, additional

Published
2022
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19. Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma

Author

Zhao, Siming, Choi, Murim, Overton, John D., Bellone, Stefania, Roque, Dana M., Cocco, Emiliano, Guzzo, Federica, English, Diana P., Varughese, Joyce, Gasparrini, Sara, Bortolomai, Ileana, Buza, Natalia, Hui, Pei, Abu-Khalaf, Maysa, Ravaggi, Antonella, Bignotti, Eliana, Bandiera, Elisabetta, Romani, Chiara, Todeschini, Paola, Tassi, Renata, Zanotti, Laura, Carrara, Luisa, Pecorelli, Sergio, Silasi, Dan-Arin, Ratner, Elena, Azodi, Masoud, Schwartz, Peter E., Rutherford, Thomas J., Stiegler, Amy L., Mane, Shrikant, Boggon, Titus J., Schlessinger, Joseph, Lifton, Richard P., and Santin, Alessandro D.

Published
2013

20. VEGF-D Serum Level as a Potential Predictor of Lymph Node Metastasis and Prognosis in Vulvar Squamous Cell Carcinoma Patients

Author

Ravaggi, Antonella, primary, Gambino, Angela, additional, Ferrari, Federico, additional, Olivari, Alessandro, additional, Zanotti, Laura, additional, Romani, Chiara, additional, Ardighieri, Laura, additional, Antonelli, Paolo, additional, Garganese, Giorgia, additional, Gallo, Daniela, additional, Scambia, Giovanni, additional, Bignotti, Eliana, additional, Sartori, Enrico, additional, Calza, Stefano, additional, and Odicino, Franco, additional

Published
2022
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22. Evaluation of Angiogenesis-Related Genes as Prognostic Biomarkers of Bevacizumab Treated Ovarian Cancer Patients: Results from the Phase IV MITO16A/ManGO OV-2 Translational Study

Author

Califano, Daniela, primary, Gallo, Daniela, additional, Rampioni Vinciguerra, Gian Luca, additional, De Cecio, Rossella, additional, Arenare, Laura, additional, Signoriello, Simona, additional, Russo, Daniela, additional, Ferrandina, Gabriella, additional, Citron, Francesca, additional, Losito, Nunzia Simona, additional, Gargiulo, Piera, additional, Simeon, Vittorio, additional, Scambia, Giovanni, additional, Cecere, Sabrina Chiara, additional, Montella, Marco, additional, Colombo, Nicoletta, additional, Tognon, Germana, additional, Bignotti, Eliana, additional, Zannoni, Gian Franco, additional, Canzonieri, Vincenzo, additional, Ciucci, Alessandra, additional, Spina, Anna, additional, Scognamiglio, Giosuè, additional, Del Sesto, Michele, additional, Schettino, Clorinda, additional, Piccirillo, Maria Carmela, additional, Perrone, Francesco, additional, Chiodini, Paolo, additional, Pignata, Sandro, additional, and Baldassarre, Gustavo, additional

Published
2021
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23. Impact of hormonal biomarkers on response to hormonal therapy in advanced and recurrent endometrial cancer

Author

van Weelden, Willem Jan, primary, Lalisang, Roy I., additional, Bulten, Johan, additional, Lindemann, Kristina, additional, van Beekhuizen, Heleen J., additional, Trum, Hans, additional, Boll, Dorry, additional, Werner, Henrica M.J., additional, van Lonkhuijzen, Luc R.C.W., additional, Yigit, Refika, additional, Forsse, David, additional, Witteveen, Petronella O., additional, Galaal, Khadra, additional, van Ginkel, Alexandra, additional, Bignotti, Eliana, additional, Weinberger, Vit, additional, Sweegers, Sanne, additional, Kroep, Judith R., additional, Cabrera, Silvia, additional, Snijders, Marc P.L.M., additional, Inda, Márcia A., additional, Eriksson, Ane Gerda Z., additional, Krakstad, Camilla, additional, Romano, Andrea, additional, van de Stolpe, Anja, additional, and Pijnenborg, Johanna M.A., additional

Published
2021
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25. Comprehensive Profiling of Hypoxia-Related miRNAs Identifies miR-23a-3p Overexpression as a Marker of Platinum Resistance and Poor Prognosis in High-Grade Serous Ovarian Cancer

Author

Todeschini, Paola, primary, Salviato, Elisa, additional, Romani, Chiara, additional, Raimondi, Vittoria, additional, Ciccarese, Francesco, additional, Ferrari, Federico, additional, Tognon, Germana, additional, Marchini, Sergio, additional, D’Incalci, Maurizio, additional, Zanotti, Laura, additional, Ravaggi, Antonella, additional, Odicino, Franco, additional, Sartori, Enrico, additional, D’Agostino, Donna M., additional, Samaja, Michele, additional, Romualdi, Chiara, additional, and Bignotti, Eliana, additional

Published
2021
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26. Infiltration by CXCL10 Secreting Macrophages Is Associated With Antitumor Immunity and Response to Therapy in Ovarian Cancer Subtypes

Author

Ardighieri, Laura, primary, Missale, Francesco, additional, Bugatti, Mattia, additional, Gatta, Luisa Benerini, additional, Pezzali, Irene, additional, Monti, Matilde, additional, Gottardi, Stefano, additional, Zanotti, Laura, additional, Bignotti, Eliana, additional, Ravaggi, Antonella, additional, Tognon, Germana, additional, Odicino, Franco, additional, Calza, Stefano, additional, Missolo-Koussou, Yoann, additional, Ries, Carola Hermine, additional, Helft, Julie, additional, and Vermi, William, additional

Published
2021
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27. Gene Expression Profiling of Olfactory Neuroblastoma Helps Identify Prognostic Pathways and Define Potentially Therapeutic Targets

Author

Romani, Chiara, primary, Bignotti, Eliana, additional, Mattavelli, Davide, additional, Bozzola, Anna, additional, Lorini, Luigi, additional, Tomasoni, Michele, additional, Ardighieri, Laura, additional, Rampinelli, Vittorio, additional, Paderno, Alberto, additional, Battocchio, Simonetta, additional, Gurizzan, Cristina, additional, Castelnuovo, Paolo, additional, Turri-Zanoni, Mario, additional, Facco, Carla, additional, Sessa, Fausto, additional, Schreiber, Alberto, additional, Ferrari, Marco, additional, Ravaggi, Antonella, additional, Deganello, Alberto, additional, Nicolai, Piero, additional, Buglione, Michela, additional, Tomasini, Davide, additional, Maroldi, Roberto, additional, Piazza, Cesare, additional, Calza, Stefano, additional, and Bossi, Paolo, additional

Published
2021
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28. Additional file 1 of Immunotherapy for the prevention of high-risk oral disorders malignant transformation: the IMPEDE trial

Author

Gurizzan, Cristina, Lorini, Luigi, Paderno, Alberto, Tomasoni, Michele, Zigliani, Gabriele, Bozzola, Anna, Ardighieri, Laura, Battocchio, Simonetta, Bignotti, Eliana, Ravaggi, Antonella, Romani, Chiara, De Cecco, Loris, Serafini, Mara Serena, Miceli, Rosalba, Bardellini, Elena, Majorana, Alessandra, Piazza, Cesare, and Bossi, Paolo

Subjects
ComputingMilieux_GENERAL, Data_FILES
Abstract

Additional file 1. Flow Chart/Time and Events Schedule.

Published
2021
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29. IMPACT OF HORMONAL BIOMARKERS ON RESPONSE TO HORMONAL THERAPY IN ADVANCED AND RECURRENT ENDOMETRIAL CANCER

Author

MS Medische Oncologie, Cancer, VAN Weelden, Willem Jan, Lalisang, Roy I, Bulten, Johan, Lindemann, Kristina, VAN Beekhuizen, Heleen J, Trum, Hans, Boll, Dorry, Werner, Henrica M J, VAN Lonkhuijzen, Luc R C W, Yigit, Refika, Forsse, David, Witteveen, Petronella O, Galaal, Khadra, VAN Ginkel, Alexandra, Bignotti, Eliana, Weinberger, Vit, Sweegers, Sanne, Kroep, Judith R, Cabrera, Silvia, Snijders, Marc P L M, Inda, Márcia A, Eriksson, Ane Gerda Z, Krakstad, Camilla, Romano, Andrea, VAN DE Stolpe, Anja, Pijnenborg, Johanna M A, MS Medische Oncologie, Cancer, VAN Weelden, Willem Jan, Lalisang, Roy I, Bulten, Johan, Lindemann, Kristina, VAN Beekhuizen, Heleen J, Trum, Hans, Boll, Dorry, Werner, Henrica M J, VAN Lonkhuijzen, Luc R C W, Yigit, Refika, Forsse, David, Witteveen, Petronella O, Galaal, Khadra, VAN Ginkel, Alexandra, Bignotti, Eliana, Weinberger, Vit, Sweegers, Sanne, Kroep, Judith R, Cabrera, Silvia, Snijders, Marc P L M, Inda, Márcia A, Eriksson, Ane Gerda Z, Krakstad, Camilla, Romano, Andrea, VAN DE Stolpe, Anja, and Pijnenborg, Johanna M A

Published
2021

30. The Claudin-Low Subtype of High-Grade Serous Ovarian Carcinoma Exhibits Stem Cell Features

Author

Romani, Chiara, primary, Capoferri, Davide, additional, Grillo, Elisabetta, additional, Silvestri, Marco, additional, Corsini, Michela, additional, Zanotti, Laura, additional, Todeschini, Paola, additional, Ravaggi, Antonella, additional, Bignotti, Eliana, additional, Odicino, Franco, additional, Sartori, Enrico, additional, Calza, Stefano, additional, and Mitola, Stefania, additional

Published
2021
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32. Expression profiles of PRKG1, SDF2L1 and PPP1R12A are predictive and prognostic factors for therapy response and survival in high-grade serous ovarian cancer

Author

Benvenuto, G, Todeschini, P, Paracchini, L, Calura, E, Fruscio, R, Romani, C, Beltrame, L, Martini, P, Ravaggi, A, Ceppi, L, Sales, G, Donati, F, Perego, P, Zanotti, L, Ballabio, S, Grassi, T, Marchette, M, Tognon, G, Sartori, E, Adorni, M, Odicino, F, D'Incalci, M, Bignotti, E, Romualdi, C, Marchini, S, Benvenuto, Giuseppe, Todeschini, Paola, Paracchini, Lara, Calura, Enrica, Fruscio, Robert, Romani, Chiara, Beltrame, Luca, Martini, Paolo, Ravaggi, Antonella, Ceppi, Lorenzo, Sales, Gabriele, Donati, Federica, Perego, Patrizia, Zanotti, Laura, Ballabio, Sara, Grassi, Tommaso, Marchette, Martina Delle, Tognon, Germana, Sartori, Enrico, Adorni, Marco, Odicino, Franco, D'Incalci, Maurizio, Bignotti, Eliana, Romualdi, Chiara, Marchini, Sergio, Benvenuto, G, Todeschini, P, Paracchini, L, Calura, E, Fruscio, R, Romani, C, Beltrame, L, Martini, P, Ravaggi, A, Ceppi, L, Sales, G, Donati, F, Perego, P, Zanotti, L, Ballabio, S, Grassi, T, Marchette, M, Tognon, G, Sartori, E, Adorni, M, Odicino, F, D'Incalci, M, Bignotti, E, Romualdi, C, Marchini, S, Benvenuto, Giuseppe, Todeschini, Paola, Paracchini, Lara, Calura, Enrica, Fruscio, Robert, Romani, Chiara, Beltrame, Luca, Martini, Paolo, Ravaggi, Antonella, Ceppi, Lorenzo, Sales, Gabriele, Donati, Federica, Perego, Patrizia, Zanotti, Laura, Ballabio, Sara, Grassi, Tommaso, Marchette, Martina Delle, Tognon, Germana, Sartori, Enrico, Adorni, Marco, Odicino, Franco, D'Incalci, Maurizio, Bignotti, Eliana, Romualdi, Chiara, and Marchini, Sergio

Abstract

High-grade serous ovarian cancer (HGS-EOCs) is generally sensitive to front-line platinum (Pt)-based chemotherapy although most patients at an advanced stage relapse with progressive resistant disease. Clinical or molecular data to identify primary resistant cases at diagnosis are not yet available. HGS-EOC biopsies from 105 Pt-sensitive (Pt-s) and 89 Pt-resistant (Pt-r) patients were retrospectively selected from two independent tumor tissue collections. Pathway analysis was done integrating miRNA and mRNA expression profiles. Signatures were further validated in silico on a cohort of 838 HGS-EOC cases from a published dataset. In all, 131 mRNAs and 5 miRNAs belonging to different functionally related molecular pathways distinguish Pt-s from Pt-r cases. Then, 17 out of 23 selected elements were validated by orthogonal approaches (SI signature). As resistance to Pt is associated with a short progression-free survival (PFS) and overall survival (OS), the prognostic role of the SI signature was assessed, and 14 genes associated with PFS and OS, in multivariate analyses (SII signature). The prognostic value of the SII signature was validated in a third extensive cohort. The expression profiles of SDF2L1, PPP1R12A and PRKG1 genes (SIII signature) served as independent prognostic biomarkers of Pt-response and survival. The study identified a prognostic molecular signature based on the combined expression profile of three genes which had never been associated with the clinical outcome of HGS-EOC. This may lead to early identification, at the time of diagnosis, of patients who would not greatly benefit from standard chemotherapy and are thus eligible for novel investigational approaches.

Published
2020

34. Genome-wide study of salivary miRNAs identifies miR-423-5p as promising diagnostic and prognostic biomarker in oral squamous cell carcinoma

Author

Romani, Chiara, primary, Salviato, Elisa, additional, Paderno, Alberto, additional, Zanotti, Laura, additional, Ravaggi, Antonella, additional, Deganello, Alberto, additional, Berretti, Giulia, additional, Gualtieri, Tommaso, additional, Marchini, Sergio, additional, D'Incalci, Maurizio, additional, Mattavelli, Davide, additional, Piazza, Cesare, additional, Bossi, Paolo, additional, Romualdi, Chiara, additional, Nicolai, Piero, additional, and Bignotti, Eliana, additional

Published
2021
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36. Cancer antigen 125, human epididymis 4, kallikrein 6, osteopontin and soluble mesothelin-related peptide immunocomplexed with immunoglobulin M in epithelial ovarian cancer diagnosis

Author

Bandiera, Elisabetta, Zanotti, Laura, Fabricio, Aline S.C., Bucca, Elisa, Squarcina, Elisa, Romani, Chiara, Tassi, Renata, Bignotti, Eliana, Todeschini, Paola, Tognon, Germana, Romagnolo, Cesare, Gion, Massimo, Sartori, Enrico, Maggino, Tiziano, Pecorelli, Sergio, and Ravaggi, Antonella

Published
2013
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39. Low Expression of Claudin-7 as Potential Predictor of Distant Metastases in High-Grade Serous Ovarian Carcinoma Patients

Author

Romani, Chiara, primary, Zizioli, Valentina, additional, Silvestri, Marco, additional, Ardighieri, Laura, additional, Bugatti, Mattia, additional, Corsini, Michela, additional, Todeschini, Paola, additional, Marchini, Sergio, additional, D'Incalci, Maurizio, additional, Zanotti, Laura, additional, Ravaggi, Antonella, additional, Facchetti, Fabio, additional, Gambino, Angela, additional, Odicino, Franco, additional, Sartori, Enrico, additional, Santin, Alessandro Davide, additional, Mitola, Stefania, additional, Bignotti, Eliana, additional, and Calza, Stefano, additional

Published
2020
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40. Expression profiles of PRKG1, SDF2L1 and PPP1R12A are predictive and prognostic factors for therapy response and survival in high‐grade serous ovarian cancer

Author

Benvenuto, Giuseppe, primary, Todeschini, Paola, additional, Paracchini, Lara, additional, Calura, Enrica, additional, Fruscio, Robert, additional, Romani, Chiara, additional, Beltrame, Luca, additional, Martini, Paolo, additional, Ravaggi, Antonella, additional, Ceppi, Lorenzo, additional, Sales, Gabriele, additional, Donati, Federica, additional, Perego, Patrizia, additional, Zanotti, Laura, additional, Ballabio, Sara, additional, Grassi, Tommaso, additional, Delle Marchette, Martina, additional, Tognon, Germana, additional, Sartori, Enrico, additional, Adorni, Marco, additional, Odicino, Franco, additional, D'Incalci, Maurizio, additional, Bignotti, Eliana, additional, Romualdi, Chiara, additional, and Marchini, Sergio, additional

Published
2020
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41. Transcriptional Characterization of Stage I Epithelial Ovarian Cancer: A Multicentric Study

Author

Calura, Enrica, primary, Ciciani, Matteo, additional, Sambugaro, Andrea, additional, Paracchini, Lara, additional, Benvenuto, Giuseppe, additional, Milite, Salvatore, additional, Martini, Paolo, additional, Beltrame, Luca, additional, Zane, Flaminia, additional, Fruscio, Robert, additional, Marchette, Martina Delle, additional, Borella, Fulvio, additional, Tognon, Germana, additional, Ravaggi, Antonella, additional, Katsaros, Dionyssios, additional, Bignotti, Eliana, additional, Odicino, Franco, additional, D’Incalci, Maurizio, additional, Marchini, Sergio, additional, and Romualdi, Chiara, additional

Published
2019
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43. Transcriptional Characterization of Stage I Epithelial Ovarian Cancer: A Multicentric Study

Author

Calura, E, Ciciani, M, Sambugaro, A, Paracchini, L, Benvenuto, G, Milite, S, Martini, P, Beltrame, L, Zane, F, Fruscio, R, Marchette, M, Borella, F, Tognon, G, Ravaggi, A, Katsaros, D, Bignotti, E, Odicino, F, D'Incalci, M, Marchini, S, Romualdi, C, Calura, Enrica, Ciciani, Matteo, Sambugaro, Andrea, Paracchini, Lara, Benvenuto, Giuseppe, Milite, Salvatore, Martini, Paolo, Beltrame, Luca, Zane, Flaminia, Fruscio, Robert, Marchette, Martina Delle, Borella, Fulvio, Tognon, Germana, Ravaggi, Antonella, Katsaros, Dionyssios, Bignotti, Eliana, Odicino, Franco, D'Incalci, Maurizio, Marchini, Sergio, Romualdi, Chiara, Calura, E, Ciciani, M, Sambugaro, A, Paracchini, L, Benvenuto, G, Milite, S, Martini, P, Beltrame, L, Zane, F, Fruscio, R, Marchette, M, Borella, F, Tognon, G, Ravaggi, A, Katsaros, D, Bignotti, E, Odicino, F, D'Incalci, M, Marchini, S, Romualdi, C, Calura, Enrica, Ciciani, Matteo, Sambugaro, Andrea, Paracchini, Lara, Benvenuto, Giuseppe, Milite, Salvatore, Martini, Paolo, Beltrame, Luca, Zane, Flaminia, Fruscio, Robert, Marchette, Martina Delle, Borella, Fulvio, Tognon, Germana, Ravaggi, Antonella, Katsaros, Dionyssios, Bignotti, Eliana, Odicino, Franco, D'Incalci, Maurizio, Marchini, Sergio, and Romualdi, Chiara

Abstract

Stage I epithelial ovarian cancer (EOC) represents about 10% of all EOCs. It is characterized by a complex histopathological and molecular heterogeneity, and it is composed of five main histological subtypes (mucinous, endometrioid, clear cell and high, and low grade serous), which have peculiar genetic, molecular, and clinical characteristics. As it occurs less frequently than advanced-stage EOC, its molecular features have not been thoroughly investigated. In this study, using in silico approaches and gene expression data, on a multicentric cohort composed of 208 snap-frozen tumor biopsies, we explored the subtype-specific molecular alterations that regulate tumor aggressiveness in stage I EOC. We found that single genes rather than pathways are responsible for histotype specificities and that a cAMP-PKA-CREB1 signaling axis seems to play a central role in histotype differentiation. Moreover, our results indicate that immune response seems to be, at least in part, involved in histotype differences, as a higher immune-reactive behavior of serous and mucinous samples was observed with respect to other histotypes.

Published
2019

45. The novel serine protease tumor-associated differentially expressed gene-15 (matriptase/MT-SP1) is highly overexpressed in cervical carcinoma

Author

Santin, Alessandro D., Cane, Stefania, Bellone, Stefania, Bignotti, Eliana, Palmieri, Michela, Casas, Luis E. De Las, Anfossi, Simone, Roman, Juan J., O'Brien, Timothy, and Pecorelli, Sergio

Subjects
Tumor antigens -- Research, Protease inhibitors -- Research, Cervical cancer -- Risk factors, Cervical cancer -- Care and treatment, Health
Published
2003

49. Mutational landscape of primary, metastatic, and recurrent ovarian cancer reveals c-MYC gains as potential target for BET inhibitors

Author

Li, Charles, primary, Bonazzoli, Elena, additional, Bellone, Stefania, additional, Choi, Jungmin, additional, Dong, Weilai, additional, Menderes, Gulden, additional, Altwerger, Gary, additional, Han, Chanhee, additional, Manzano, Aranzazu, additional, Bianchi, Anna, additional, Pettinella, Francesca, additional, Manara, Paola, additional, Lopez, Salvatore, additional, Yadav, Ghanshyam, additional, Riccio, Francesco, additional, Zammataro, Luca, additional, Zeybek, Burak, additional, Yang-Hartwich, Yang, additional, Buza, Natalia, additional, Hui, Pei, additional, Wong, Serena, additional, Ravaggi, Antonella, additional, Bignotti, Eliana, additional, Romani, Chiara, additional, Todeschini, Paola, additional, Zanotti, Laura, additional, Zizioli, Valentina, additional, Odicino, Franco, additional, Pecorelli, Sergio, additional, Ardighieri, Laura, additional, Silasi, Dan-Arin, additional, Litkouhi, Babak, additional, Ratner, Elena, additional, Azodi, Masoud, additional, Huang, Gloria S., additional, Schwartz, Peter E., additional, Lifton, Richard P., additional, Schlessinger, Joseph, additional, and Santin, Alessandro D., additional

Published
2018
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50. Mammaglobin B is an independent prognostic marker in epithelial ovarian cancer and its expression is associated with reduced risk of disease recurrence

Author

Bandiera Elisabetta, Romani Chiara, Rossi Elisa, Todeschini Paola, Falchetti Marcella, Donzelli Carla, Tognon Germana, Odicino Franco E, Bignotti Eliana, Ravaggi Antonella, Calza Stefano, Tassi Renata A, Zanotti Laura, Pecorelli Sergio, and Santin Alessandro D

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Traditional prognostic factors in epithelial ovarian cancer (EOC) are inadequate in predicting recurrence and long-term prognosis, but genome-wide cancer research has recently provided multiple potentially useful biomarkers. The gene codifying for Mammaglobin B (MGB-2) has been selected from our previous microarray analysis performed on 19 serous papillary epithelial ovarian cancers and its expression has been further investigated on multiple histological subtypes, both at mRNA and protein level. Since, to date, there is no information available on the prognostic significance of MGB-2 expression in cancer, the aim of this study was to determine its prognostic potential on survival in a large cohort of well-characterized EOC patients. Methods MGB-2 expression was evaluated by quantitative real time-PCR in fresh-frozen tissue biopsies and was validated by immunohistochemistry in matched formalin fixed-paraffin embedded tissue samples derived from a total of 106 EOC patients and 27 controls. MGB-2 expression was then associated with the clinicopathologic features of the tumors and was correlated with clinical outcome. Results MGB-2 expression was found significantly elevated in EOC compared to normal ovarian controls, both at mRNA and protein level. A good correlation was detected between MGB-2 expression data obtained by the two different techniques. MGB-2 expressing tumors were significantly associated with several clinicopathologic characteristics defining a less aggressive tumor behavior. Univariate survival analysis revealed a decreased risk for cancer-related death, recurrence and disease progression in MGB-2-expressing patients (p < 0.05). Moreover, multivariate analysis indicated that high expression levels of MGB-2 transcript (HR = 0.25, 95%, 0.08–0.75, p = 0.014) as well as positive immunostaining for the protein (HR = 0.41, 95%CI, 0.17–0.99, p = 0.048) had an independent prognostic value for disease-free survival. Conclusion This is the first report documenting that MGB-2 expression characterizes less aggressive forms of EOC and is correlated with a favorable outcome. These findings suggest that the determination of MGB-2, especially at molecular level, in EOC tissue obtained after primary surgery can provide additional prognostic information about the risk of recurrence.

Published
2009
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