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116 results on '"Bigazzi, Mario"'

2. Relaxin has beneficial effects on liver lipidome and metabolic enzymes

Author

Aragón‐Herrera, Alana, primary, Feijóo‐Bandín, Sandra, additional, Moraña‐Fernández, Sandra, additional, Anido‐Varela, Laura, additional, Roselló‐Lletí, Esther, additional, Portolés, Manuel, additional, Tarazón, Estefanía, additional, Lage, Ricardo, additional, Moscoso, Isabel, additional, Barral, Luis, additional, Bani, Daniele, additional, Bigazzi, Mario, additional, Gualillo, Oreste, additional, González‐Juanatey, José Ramón, additional, and Lago, Francisca, additional

Published
2021
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8. Serelaxin (recombinant human relaxin-2) treatment affects the endogenous synthesis of long chain poly-unsaturated fatty acids and induces substantial alterations of lipidome and metabolome profiles in rat cardiac tissue

Author

Aragón-Herrera, Alana, primary, Feijóo-Bandín, Sandra, additional, Abella, Vanessa, additional, Álvarez, Lucía, additional, Roselló-Lletí, Esther, additional, Portolés, Manuel, additional, Tarazón, Estefanía, additional, Bigazzi, Mario, additional, Bani, Daniele, additional, Gualillo, Oreste, additional, González-Juanatey, José Ramón, additional, and Lago, Francisca, additional

Published
2019
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9. Rehabilitation with robotic glove (Gloreha) in poststroke patients

Author

Milia, Paolo, primary, Peccini, MariaCristina, additional, De Salvo, Federico, additional, Sfaldaroli, Alice, additional, Grelli, Chiara, additional, Lucchesi, Giorgia, additional, Sadauskas, Nora, additional, Rossi, Catia, additional, Caserio, Marco, additional, and Bigazzi, Mario, additional

Published
2019
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15. Efficacy and safety of oral porcine relaxin (pRLX) in adjunct to physical exercise in the treatment of peripheral arterial disease (PAD)

Author

Sonaglia, Francesco, Milia, Paolo, Caserio, Marco, Bigazzi, Bernardo, Bigazzi, Benedetta, Ricotta, Serena, Bani, Daniele, and Bigazzi, Mario

Abstract

Introduction PAD medical therapy has a number of limitations. RLX showed promises in experimental model mainly through NO release. Our study is the first to evaluate the efficacy and safety of RLX in PAD. Materials-Methods eligible PAD La fontaine IIa-IIb patients were randomized in 2 groups. Group A was treated with physical therapy plus oral pRLX, 20 ug b.i.d for 12 weeks, group B received physical therapy alone. Pain Free Walking Distance (PFWD) and Maximum Walking Distance (MWD) at 3 and 12 wks and at follow up 3 months after treatment interruption were performed. Results The percentage increases of PFWD in group B were 23±9, 65±17, and 35±4 respectively at 3 and at 12 weeks. and 3 months after termination. In Group A showed significantly higher percentage increases: 74±16 p, Italian Journal of Anatomy and Embryology, Vol 118, No 1 (Supplement) 2013

Published
2014
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16. Neurorehabilitation in paraplegic patients with an active powered exoskeleton (Ekso)

Author

Milia, Paolo, primary, De Salvo, Federico, additional, Caserio, Marco, additional, Cope, Tyler, additional, Weber, Patti, additional, Santella, Caroline, additional, Fiorini, Stefano, additional, Baldoni, Giacomo, additional, Bruschi, Riccardo, additional, Bigazzi, Benedetta, additional, Cencetti, Stefano, additional, Da Campo, Marco, additional, Bigazzi, Prospero, additional, and Bigazzi, Mario, additional

Published
2016
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37. HUMAN DECIDUAL RELAXIN.

Author

Bigazzi, Mario, Bruni, Paola, Nardi, Emma, Petrucci, Fabrizia, Pollicino, Guiseppe, Franchini, Mario, Scarselli, Gianfranco, and Farnararo, Marta

Published
1982
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42. Relaxin up‐regulates inducible nitric oxide synthase expression and nitric oxide generation in rat coronary endothelial cells

Author

Failli, Paola, Nistri, Silvia, Quattrone, Silvia, Mazzetti, Luca, Bigazzi, Mario, Sacchi, Tatiana Bani, and Bani, Daniele

Abstract

Relaxin (RLX) is a reproductive hormone with vasodilatatory properties on several organs, including the heart. RLX‐induced vasodilatation appears to depend on the stimulation of endogenous NO production. Here, we investigate whether RLX acts on rat coronary endothelial (RCE) cells in vitroby inducing changes of NO generation and, if so, to clarify the possible mechanism of action. RCE cells were treated for 24 h with vehicle (controls) or RLX, alone or in association with inhibitors of NO synthesis or dexamethasone, which inhibits transcription of NO synthase gene. In some experiments, inactivated RLX was given in the place of authentic RLX. Expression of NO synthase isozymes II and III was analyzed by immunocytochemistry, Western blot, and RT‐PCR. NO production was evaluated by the Griess reaction for nitrite and the NO‐sensitive fluorophore DAF‐2/DA. Agonist‐induced changes of intracellular Ca2+transient were studied with the Ca2+‐sensitive fluorophore Fura 2‐AM. RLX was found to up regulate NOS II mRNA and protein and to stimulate intrinsic NO generation, likely through the activation of a dexamethasone‐sensitive transcription factor, and to decrease agonist‐induced intracellular Ca2+transient. Conversely, RLX had negligible effects on NOS III expression. By these biological effects, RLX may afford significant protection against cardiovascular disease.

Published
2002
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43. Relaxin: a mammotropic hormone promoting growth and differentiation of the pigeon crop sac mucosa

Author

Bigazzi, Mario, Bani, Gastone, Sacchi, Tatiana Bani, Petrucci, Fabrizia, and Bianchi, Stefano

Abstract

Abstract. The pigeon crop sac is responsive to local administration of mammotropic hormones independently of systemic hormonal influences. We showed previously in mice that relaxin promotes growth of the mammary gland only after pre-treatment with estrogen. In this study we investigated whether relaxin, locally administered, has a stimulatory effect without estrogen pre-treatment. The results of this study show that relaxin stimulates the crop sac mucosa causing changes in its gross appearance and histological modifications indicating enhanced growth and differentiation of the mucosal epithelium. The effects of relaxin are dose-related, as demonstrated by the increases of the wet and dry weights, the [3H]thymidine and [3H]uridine uptakes of the mucosa, and the histochemically detectable DNA content of the mucosal epithelium. These results strengthen the idea that relaxin should be included in the list of mammotropic hormones.

Published
1988
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45. Effects of relaxin on the microvasculature of mouse mammary gland

Author

Bani, Gastone, Bani-Sacchi, Tatiana, Bigazzi, Mario, and Bianchi, Stefano

Subjects
6 - Ciencias aplicadas::61 - Medicina [CDU], Relaxin, Mammary gland
Abstract

The effects of RLX on the microvasculature of the mouse mammary gland are reported. RLX (pure porcine standard NIH-RXN-P1) at a dose of 3 GPU was administered subcutaneously to virgin adult mice ovariectomized 12 days before. The mammary glands were removed 18-20 h after RLX injection and their examination by light microscopy did not reveal any substantial growth-response to the hormone . Histology and morphometry indicated striking dilation of microvessels, especially capillaries. and electron microscopy revealed an increase in the micropinocytotic vesicles, thus suggesting enhanced transendothelial transport of substances. Such phenomena, which were independent of a release of granules by mast cells, may represent an important component of the mammotrophic action of RLX.

Published
1988

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