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4. Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival

Author

Rahman, Mohummad Aminur, Gras Navarro, Andrea, Brekke, Jorunn, Engelsen, Agnete, Bindesbøll, Christian, Sarowar, Shahin, Bahador, Marzieh, Bifulco, Ersilia, Goplen, Dorota, Waha, Andreas, Lie, Stein Atle, Gjertsen, Bjørn Tore, Selheim, Frode, Enger, Per Øyvind, Simonsen, Anne, and Chekenya, Martha

Published
2019
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5. Drug monitoring of tamoxifen metabolites predicts vaginal dryness and verifies a low discontinuation rate from the Norwegian Prescription Database

Author

Helland, Thomas, Hagen, Kari Britt, Haugstøyl, Martha Eimstad, Kvaløy, Jan Terje, Lunde, Siri, Lode, Kirsten, Lind, Ragna Anne, Gripsrud, Birgitta Haga, Jonsdottir, Kristin, Gjerde, Jennifer, Bifulco, Ersilia, Hustad, Steinar, Jonassen, Janne, Aas, Turid, Lende, Tone Hoel, Lien, Ernst Asbjørn, Janssen, Emiel Adrianus Maria, Søiland, Håvard, and Mellgren, Gunnar

Published
2019
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7. Menopause as a predictor of new-onset asthma: A longitudinal Northern European population study

Author

Triebner, Kai, Johannessen, Ane, Puggini, Luca, Benediktsdóttir, Bryndís, Bertelsen, Randi J., Bifulco, Ersilia, Dharmage, Shyamali C., Dratva, Julia, Franklin, Karl A., Gíslason, Thórarinn, Holm, Mathias, Jarvis, Deborah, Leynaert, Bénédicte, Lindberg, Eva, Malinovschi, Andrei, Macsali, Ferenc, Norbäck, Dan, Omenaas, Ernst R., Rodríguez, Francisco J., Saure, Eirunn, Schlünssen, Vivi, Sigsgaard, Torben, Skorge, Trude D., Wieslander, Gunilla, Zemp, Elisabeth, Svanes, Cecilie, Hustad, Steinar, and Gómez Real, Francisco

Published
2016
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9. Steroidogenic factor 1 (NR5A1) induces multiple transcriptional changes during differentiation of human gonadal-like cells

Author

Sepponen, Kirsi, primary, Lundin, Karolina, additional, Yohannes, Dawit A., additional, Vuoristo, Sanna, additional, Balboa, Diego, additional, Poutanen, Matti, additional, Ohlsson, Claes, additional, Hustad, Steinar, additional, Bifulco, Ersilia, additional, Paloviita, Pauliina, additional, Otonkoski, Timo, additional, Ritvos, Olli, additional, Sainio, Kirsi, additional, Tapanainen, Juha S., additional, and Tuuri, Timo, additional

Published
2022
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13. Ultraviolet radiation as a predictor of sex hormone levels in postmenopausal women : A European multi-center study (ECRHS)

Author

Triebner, Kai, Bifulco, Ersilia, Barrera-Gómez, José, Basagaña, Xavier, Benediktsdóttir, Bryndís, Forsberg, Bertil, Franklin, Karl A., Garcia-Larsen, Vanessa, Leynaert, Bénédicte, Lindberg, Eva, Martínez-Moratalla, Jesús, Muniozguren-Agirre, Nerea, Pin, Isabelle, Raherison, Chantal, Pereira-Vega, Antonio, Schlünssen, Vivi, Valentin, Antonia, Hustad, Steinar, Gómez Real, Francisco, Dadvand, Payam, Triebner, Kai, Bifulco, Ersilia, Barrera-Gómez, José, Basagaña, Xavier, Benediktsdóttir, Bryndís, Forsberg, Bertil, Franklin, Karl A., Garcia-Larsen, Vanessa, Leynaert, Bénédicte, Lindberg, Eva, Martínez-Moratalla, Jesús, Muniozguren-Agirre, Nerea, Pin, Isabelle, Raherison, Chantal, Pereira-Vega, Antonio, Schlünssen, Vivi, Valentin, Antonia, Hustad, Steinar, Gómez Real, Francisco, and Dadvand, Payam

Abstract

Background: Solar ultraviolet radiation (UVR) affects the body through pathways that exhibit positive as well as negative health effects such as immunoregulation and vitamin D production. Different vitamin D metabolites are associated with higher or lower concentrations of estrogens and may thus alter the female sex hormone balance. Objective: To study whether exposure to UVR, as a modifiable lifestyle factor, is associated with levels of sex hormones (17β-estradiol, estrone, estrone 3-sulfate, testosterone, dehydroepiandrosterone sulfate), gonadotropins (follicle stimulating hormone, luteinizing hormone) as well as sex hormone binding globulin in postmenopausal women, and thus investigate whether managing UVR exposure can influence the hormone balance, with potential benefits for the biological aging process. Methods: The study included 580 postmenopausal women from six European countries, participating in the European Community Respiratory Health Survey (2010–2014). Average UVR exposure during the month before blood sampling was estimated based on personal sun behavior and ambient levels. Hormone concentrations were measured in serum using state-of-the-art methods. Subsequently we applied linear mixed-effects models, including center as random intercept, hormone concentrations (one at a time) as outcome and UVR, age, skin type, body mass index, vitamin D from dietary sources, smoking, age at completed full-time education and season of blood sampling as fixed-effect predictors. Results: One interquartile range increase in UVR exposure was associated with decreased levels of 17β-estradiol (-15.6 pmol/L, 95 % Confidence Interval (CI): -27.69, -3.51) and estrone (-13.36 pmol/L, 95 % CI: -26.04, -0.68) and increased levels of follicle stimulating hormone (9.34IU/L, 95 % CI: 2.91, 15.77) and luteinizing hormone (13.86 IU/daL, 95 % CI: 2.48, 25.25). Conclusions: Exposure to UVR is associated with decreased estrogens and increased gonadotropins in postmenopausal women, a

Published
2021
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14. Ultraviolet radiation as a predictor of sex hormone levels in postmenopausal women: A European multi-center study (ECRHS)

Author

Triebner, Kai, primary, Bifulco, Ersilia, additional, Barrera-Gómez, Jose, additional, Basagaña, Xavier, additional, Benediktsdóttir, Bryndís, additional, Forsberg, Bertil, additional, Franklin, Karl A., additional, Garcia-Larsen, Vanessa, additional, Leynaert, Bénédicte, additional, Lindberg, Eva, additional, Martínez-Moratalla, Jesús, additional, Muniozguren-Agirre, Nerea, additional, Pin, Isabelle, additional, Raherison, Chantal, additional, Pereira-Vega, Antonio, additional, Schlünssen, Vivi, additional, Valentin, Antonia, additional, Hustad, Steinar, additional, Real, Francisco Gómez, additional, and Dadvand, Payam, additional

Published
2021
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15. Low Z‐4OHtam concentrations are associated with adverse clinical outcome among early stage premenopausal breast cancer patients treated with adjuvant tamoxifen

Author

Helland, Thomas, primary, Naume, Bjørn, additional, Hustad, Steinar, additional, Bifulco, Ersilia, additional, Kvaløy, Jan Terje, additional, Sætersdal, Anna Barbro, additional, Synnestvedt, Marit, additional, Lende, Tone Hoel, additional, Gilje, Bjørnar, additional, Mjaaland, Ingvil, additional, Weyde, Kjetil, additional, Blix, Egil Støre, additional, Wiedswang, Gro, additional, Borgen, Elin, additional, Hertz, Daniel Louis, additional, Janssen, Emiel Adrianus Maria, additional, Mellgren, Gunnar, additional, and Søiland, Håvard, additional

Published
2020
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16. Relationship between CYP2D6 genotype, tamoxifen metabolites, and adverse events, tumor biomarkers and breast cancer recurrence in a low-dose phase III trial in noninvasive disease.

Author

De Censi, Andrea, primary, Johansson, Harriet Ann, additional, Helland, Thomas, additional, Puntoni, Matteo, additional, Buttiron Webber, Tania, additional, Macis, Debora, additional, Aristarco, Valentina, additional, Briata, Irene Maria, additional, Serrano, Davide, additional, D'Amico, Mauro, additional, Bifulco, Ersilia, additional, Hustad, Steinar, additional, Søiland, Håvard, additional, Bonanni, Bernardo, additional, and Mellgren, Gunnar, additional

Published
2020
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17. Exogenous female sex steroids may reduce lung ageing after menopause : A 20-year follow-up study of a general population sample (ECRHS)

Author

Triebner, Kai, Accordini, Simone, Calciano, Lucia, Johannessen, Ane, Benediktsdottir, Bryndis, Bifulco, Ersilia, Demoly, Pascal, Dharmage, Shyamali C., Franklin, Karl A., Garcia-Aymerich, Judith, Gullon Blanco, Jose Antonio, Heinrich, Joachim, Holm, Mathias, Jarvis, Debbie, Jogi, Rain, Lindberg, Eva, Martinez-Moratalla, Jesus, Muniozguren Agirre, Nerea, Pin, Isabelle, Probst-Hensch, Nicole, Raherison, Chantal, Luis Sanchez-Ramos, Jose, Schlunssen, Vivi, Svanes, Cecilie, Hustad, Steinar, Leynaert, Benedicte, Real, Francisco Gomez, Triebner, Kai, Accordini, Simone, Calciano, Lucia, Johannessen, Ane, Benediktsdottir, Bryndis, Bifulco, Ersilia, Demoly, Pascal, Dharmage, Shyamali C., Franklin, Karl A., Garcia-Aymerich, Judith, Gullon Blanco, Jose Antonio, Heinrich, Joachim, Holm, Mathias, Jarvis, Debbie, Jogi, Rain, Lindberg, Eva, Martinez-Moratalla, Jesus, Muniozguren Agirre, Nerea, Pin, Isabelle, Probst-Hensch, Nicole, Raherison, Chantal, Luis Sanchez-Ramos, Jose, Schlunssen, Vivi, Svanes, Cecilie, Hustad, Steinar, Leynaert, Benedicte, and Real, Francisco Gomez

Abstract

Objectives: Menopause involves hypoestrogenism, which is associated with numerous detrimental effects, including on respiratory health. Hormone replacement therapy (HRT) is often used to improve symptoms of menopause. The effects of HRT on lung function decline, hence lung ageing, have not yet been investigated despite the recognized effects of HRT on other health outcomes. Study design: The population-based multi-centre European Community Respiratory Health Survey provided complete data for 275 oral HRT users at two time points, who were matched with 383 nonusers and analysed with a two-level linear mixed effects regression model. Main outcome measures: We studied whether HRT use was associated with the annual decline in forced vital capacity (FVC) and forced expiratory volume in one second (FEV1). Results: Lung function of women using oral HRT for more than five years declined less rapidly than that of nonusers. The adjusted difference in FVC decline was 5.6 mL/y (95%CI: 1.8 to 9.3, p = 0.01) for women who had taken HRT for six to ten years and 8.9 mL/y (3.5 to 14.2, p = 0.003) for those who had taken it for more than ten years. The adjusted difference in FEV1 decline was 4.4 mL/y (0.9 to 8.0, p = 0.02) with treatment from six to ten years and 5.3 mL/y (0.4 to 10.2, p = 0.048) with treatment for over ten years. Conclusions: In this longitudinal population-based study, the decline in lung function was less rapid in women who used HRT, following a dose-response pattern, and consistent when adjusting for potential confounding factors. This may signify that female sex hormones are of importance for lung ageing.

Published
2019
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18. Exogenous female sex steroids may reduce lung ageing after menopause: A 20-year follow-up study of a general population sample (ECRHS)

Author

Triebner, Kai, primary, Accordini, Simone, additional, Calciano, Lucia, additional, Johannessen, Ane, additional, Benediktsdóttir, Bryndís, additional, Bifulco, Ersilia, additional, Demoly, Pascal, additional, Dharmage, Shyamali C., additional, Franklin, Karl A., additional, Garcia-Aymerich, Judith, additional, Gullón Blanco, José Antonio, additional, Heinrich, Joachim, additional, Holm, Mathias, additional, Jarvis, Debbie, additional, Jõgi, Rain, additional, Lindberg, Eva, additional, Martínez-Moratalla, Jesús, additional, Muniozguren Agirre, Nerea, additional, Pin, Isabelle, additional, Probst-Hensch, Nicole, additional, Raherison, Chantal, additional, Sánchez-Ramos, José Luis, additional, Schlünssen, Vivi, additional, Svanes, Cecilie, additional, Hustad, Steinar, additional, Leynaert, Bénédicte, additional, and Gómez Real, Francisco, additional

Published
2019
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19. Low Z‐4OHtam concentrations are associated with adverse clinical outcome among early stage premenopausal breast cancer patients treated with adjuvant tamoxifen.

Author

Helland, Thomas, Naume, Bjørn, Hustad, Steinar, Bifulco, Ersilia, Kvaløy, Jan Terje, Sætersdal, Anna Barbro, Synnestvedt, Marit, Lende, Tone Hoel, Gilje, Bjørnar, Mjaaland, Ingvil, Weyde, Kjetil, Blix, Egil Støre, Wiedswang, Gro, Borgen, Elin, Hertz, Daniel Louis, Janssen, Emiel Adrianus Maria, Mellgren, Gunnar, and Søiland, Håvard

Abstract

Low steady‐state levels of active tamoxifen metabolites have been associated with inferior treatment outcomes. In this retrospective analysis of 406 estrogen receptor‐positive breast cancer (BC) patients receiving adjuvant tamoxifen as initial treatment, we have associated our previously reported thresholds for the two active metabolites, Z‐endoxifen and Z‐4‐hydroxy‐tamoxifen (Z‐4OHtam), with treatment outcomes in an independent cohort of BC patients. Among all patients, metabolite levels did not affect survival. However, in the premenopausal subgroup receiving tamoxifen alone (n = 191) we confirmed an inferior BC ‐specific survival in patients with the previously described serum concentration threshold of Z‐4OHtam ≤ 3.26 nm (HR = 2.37, 95% CI = 1.02–5.48, P = 0.039). The 'dose–response' survival trend in patients categorized to ordinal concentration cut‐points of Z‐4OHtamoxifen (≤ 3.26, 3.27–8.13, > 8.13 nm) was also replicated (P‐trend log‐rank = 0.048). Z‐endoxifen was not associated with outcome. This is the first study to confirm the association between a published active tamoxifen metabolite threshold and BC outcome in an independent patient cohort. Premenopausal patients receiving 5‐year of tamoxifen alone may benefit from therapeutic drug monitoring to ensure tamoxifen effectiveness. [ABSTRACT FROM AUTHOR]

Published
2021
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20. Additional file 1: Table S1. of Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients

Author

Helland, Thomas, Henne, Nina, Bifulco, Ersilia, Naume, Bjørn, Borgen, Elin, Kristensen, Vessela, Kvaløy, Jan, Lash, Timothy, Alnæs, Grethe, Schaik, Ron Van, Janssen, Emiel, Hustad, Steinar, Lien, Ernst, Mellgren, Gunnar, and Søiland, Håvard

Abstract

Alleles analyzed by INFINITI®. (DOCX 14 kb)

Published
2017
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21. Additional file 3: Table S3. of Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients

Author

Helland, Thomas, Henne, Nina, Bifulco, Ersilia, Naume, Bjørn, Borgen, Elin, Kristensen, Vessela, Kvaløy, Jan, Lash, Timothy, Alnæs, Grethe, Schaik, Ron Van, Janssen, Emiel, Hustad, Steinar, Lien, Ernst, Mellgren, Gunnar, and Søiland, Håvard

Subjects
TheoryofComputation_LOGICSANDMEANINGSOFPROGRAMS
Abstract

Imprecision and accuracy. (DOCX 16 kb)

Published
2017
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22. Additional file 4: Table S4. of Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients

Author

Helland, Thomas, Henne, Nina, Bifulco, Ersilia, Naume, Bjørn, Borgen, Elin, Kristensen, Vessela, Kvaløy, Jan, Lash, Timothy, Alnæs, Grethe, Schaik, Ron Van, Janssen, Emiel, Hustad, Steinar, Lien, Ernst, Mellgren, Gunnar, and Søiland, Håvard

Abstract

Retention times, molecular weights, and compound-dependent instrument settings. (DOCX 16 kb)

Published
2017
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23. Additional file 5: Table S5. of Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients

Author

Helland, Thomas, Henne, Nina, Bifulco, Ersilia, Naume, Bjørn, Borgen, Elin, Kristensen, Vessela, Kvaløy, Jan, Lash, Timothy, Alnæs, Grethe, Schaik, Ron Van, Janssen, Emiel, Hustad, Steinar, Lien, Ernst, Mellgren, Gunnar, and Søiland, Håvard

Abstract

Linear dynamic range of the assay. (DOCX 14 kb)

Published
2017
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24. Additional file 2: Table S2. of Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients

Author

Helland, Thomas, Henne, Nina, Bifulco, Ersilia, Naume, Bjørn, Borgen, Elin, Kristensen, Vessela, Kvaløy, Jan, Lash, Timothy, Alnæs, Grethe, Schaik, Ron Van, Janssen, Emiel, Hustad, Steinar, Lien, Ernst, Mellgren, Gunnar, and Søiland, Håvard

Subjects
information science, natural sciences, skin and connective tissue diseases, hormones, hormone substitutes, and hormone antagonists, health care economics and organizations
Abstract

Suppliers and catalog numbers for tamoxifen metabolites. (DOCX 14 kb)

Published
2017
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25. Additional file 7: Table S6. of Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients

Author

Helland, Thomas, Henne, Nina, Bifulco, Ersilia, Naume, Bjørn, Borgen, Elin, Kristensen, Vessela, Kvaløy, Jan, Lash, Timothy, Alnæs, Grethe, Schaik, Ron Van, Janssen, Emiel, Hustad, Steinar, Lien, Ernst, Mellgren, Gunnar, and Søiland, Håvard

Abstract

CYP2D6 allele frequencies. (DOCX 13 kb)

Published
2017
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26. Additional file 8: Table S7. of Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients

Author

Helland, Thomas, Henne, Nina, Bifulco, Ersilia, Naume, Bjørn, Borgen, Elin, Kristensen, Vessela, Kvaløy, Jan, Lash, Timothy, Alnæs, Grethe, Schaik, Ron Van, Janssen, Emiel, Hustad, Steinar, Lien, Ernst, Mellgren, Gunnar, and Søiland, Håvard

Subjects
skin and connective tissue diseases, hormones, hormone substitutes, and hormone antagonists
Abstract

Concentrations of tamoxifen metabolites stratified by metabolizer group. (DOCX 14 kb)

Published
2017
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27. Additional file 6: of Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients

Author

Helland, Thomas, Henne, Nina, Bifulco, Ersilia, Naume, Bjørn, Borgen, Elin, Kristensen, Vessela, Kvaløy, Jan, Lash, Timothy, Alnæs, Grethe, Schaik, Ron Van, Janssen, Emiel, Hustad, Steinar, Lien, Ernst, Mellgren, Gunnar, and Søiland, Håvard

Abstract

Additional methods. Description of methods to determine cut-off values. (DOCX 17 kb)

Published
2017
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28. Additional file 9: Figure S1. of Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients

Author

Helland, Thomas, Henne, Nina, Bifulco, Ersilia, Naume, Bjørn, Borgen, Elin, Kristensen, Vessela, Kvaløy, Jan, Lash, Timothy, Alnæs, Grethe, Schaik, Ron Van, Janssen, Emiel, Hustad, Steinar, Lien, Ernst, Mellgren, Gunnar, and Søiland, Håvard

Subjects
polycyclic compounds, skin and connective tissue diseases, hormones, hormone substitutes, and hormone antagonists
Abstract

Kaplan-Meier plot of breast cancer-specific survival according to Antiestrogenic Activity Score. (DOCX 109 kb)

Published
2017
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30. Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients

Author

Helland, Thomas, primary, Henne, Nina, additional, Bifulco, Ersilia, additional, Naume, Bjørn, additional, Borgen, Elin, additional, Kristensen, Vessela N., additional, Kvaløy, Jan T., additional, Lash, Timothy L., additional, Alnæs, Grethe I. G., additional, van Schaik, Ron H., additional, Janssen, Emiel A. M., additional, Hustad, Steinar, additional, Lien, Ernst A., additional, Mellgren, Gunnar, additional, and Søiland, Håvard, additional

Published
2017
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31. Hormone replacement therapy may preserve lung function during reproductive aging

Author

Triebner, Kai, primary, Accordini, Simone, additional, Calciano, Lucia, additional, Johannessen, Ane, additional, Benediktsdóttir, Bryndís, additional, Bifulco, Ersilia, additional, Demoly, Pascal, additional, Dharmage, Shyamali, additional, Franklin, Karl, additional, Garcia-Aymerich, Judith, additional, Gullón Blanco, José Antonio, additional, Heinrich, Joachim, additional, Holm, Mathias, additional, Jarvis, Debbie, additional, Jõgi, Rain, additional, Lindberg, Eva, additional, Moratalla Rovira, Jesús Martínez, additional, Muniozguren Agirre, Nerea, additional, Pin, Isabelle, additional, Probst-Hensch, Nicole, additional, Raherison, Chantal, additional, Sánchez-Ramos, José Luis, additional, Schlünssen, Vivi, additional, Svanes, Cecilie, additional, Hustad, Steinar, additional, Leynaert, Bénédicte, additional, and Gómez Real, Francisco, additional

Published
2017
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32. Menopause as a predictor of new-onset asthma

Author

Triebner, Kai, Johannessen, Ane, Puggini, Luca, Benediktsdottir, Bryndis, Bertelsen, Randi Jacobsen, Bifulco, Ersilia, Dharmage, Shyamali C., Franklin, Karl A., Gislason, Þórarinn, Holm, Mathias, Jarvis, Deborah, Leynaert, Bénédicte, Lindberg, Eva, Macsali, Ferenc, Malinovschi, Andrej, Norbäck, Dan, Omenaas, Ernst, Rodriguez, Francisco J, Saure, Eirunn Waatevik, Schlünssen, Vivi, Sigsgaard, Torben, Skorge, Trude Duelien, Wieslander, Gunilla, Zemp, Elisabeth, Svanes, Cecilie, Hustad, Simon Steinar, and Gomez Real, Francisco

Subjects
menopausal asthma, longitudinal, reproductive aging, respiratory symptoms, Respiratory Health in Northern Europe, menopause, asthma, Amenorrhea, sex hormones, estrogens
Abstract

Background: There is limited and conflicting evidence on the effect of menopause on asthma. Objectives: We sought to study whether the incidence of asthma and respiratory symptoms differ by menopausal status in a longitudinal population-based study with an average follow-up of 12 years. Methods: The Respiratory Health in Northern Europe study provided questionnaire data pertaining to respiratory and reproductive health at baseline (1999-2001) and follow-up (2010-2012). The study cohort included women aged 45 to 65 years at follow-up, without asthma at baseline, and not using exogenous hormones (n 5 2322). Menopausal status was defined as nonmenopausal, transitional, early postmenopausal, and late postmenopausal. Associations with asthma (defined by the use of asthma medication, having asthma attacks, or both) and respiratory symptoms scores were analyzed by using logistic (asthma) and negative binomial (respiratory symptoms) regressions, adjusting for age, body mass index, physical activity, smoking, education, and study center. Results: The odds of new-onset asthma were increased in women who were transitional (odds ratio, 2.40; 95% CI, 1.09-5.30), early postmenopausal (odds ratio, 2.11; 95% CI,1.06-4.20), and late postmenopausal (odds ratio, 3.44; 95% CI, 1.31-9.05) at follow-up compared with nonmenopausal women. The risk of respiratory symptoms increased in early postmenopausal (coefficient, 0.40; 95% CI, 0.06-0.75) and late postmenopausal (coefficient, 0.69; 95% CI, 0.15-1.23) women. These findings were consistent irrespective of smoking status and across study centers. Conclusions: New-onset asthma and respiratory symptoms increased in women becoming postmenopausal in a longitudinal population-based study. Clinicians should be aware that respiratory health might deteriorate in women during reproductive aging. (J Allergy Clin Immunol 2016;137:50-7.) publishedVersion

Published
2015

33. Antioxidant activity of Mediterranean food: The case of cannonau wine, myrtle berries liqueur and strawberry-tree honey

Author

Tuberoso, Carlo I.G., Boban, Mladen, Bifulco, Ersilia, Budimir, Danijela, and Pirisi, Filippo M.

Subjects
wine, liqueur, honey, antioxidant, vasodilation
Abstract

A diet rich in antioxidant compounds is essential in preventing oxidative damage in humans. The Mediterranean diet is famous worldwide for being rich in antioxidants. Among these antioxidants, polyphenols are a group of molecules with proved antioxidant properties and protective effects against LDL oxidation and platelets aggregation. The aim of this work was to use different assays to evaluate the antioxidant properties of three typical food products from the Mediterranean area and to correlate these activities with their phenolic content. For this purpose, a red wine (cv. Cannonau ), a liqueur obtained by cold maceration of myrtle ( Myrtus communis L.) berries and a bitter honey obtained from strawberry-tree flowers ( Arbutus unedo L.) were analyzed. The total phenols (TP) content was measured by spectrophotometric determination with a modified Folin-Ciocalteau method and phenolic compounds were identified and dosed by LC-DAD-MS (Rosa et al , 2011 ; Tuberoso et al , 2010). Antioxidant activities were evaluated with the DPPH, FRAP and ABTS assays and the direct vasodilatory effects were assessed using norepinephrine preconrtracted rat aortic rings. Cannonau wine and myrtle liqueur showed high levels of TP (1732.0±98.7 and 1840.9±10.8 mg GAE/kg, respectively), linearly correlated to FRAP, ABTS and DPPH values. Their maximal vasodilatory activity was 62±4% and 53±3%, respectively. Although straw-berry tree honey contained relatively high levels of phenolic compounds (930.8 mg GAE/kg), it did not induce significant vasodilation, and even at the highest dose tested (0.206 g/L). These results indicate that foods with high levels of phenolics should be studied using several antioxidant assays before being recommended to the public as functional foods.

Published
2012

39. Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits

Author

Ntalli, Nikoletta G., primary, Cottiglia, Filippo, additional, Bueno, Carlos A., additional, Alché, Laura E., additional, Leonti, Marco, additional, Vargiu, Simona, additional, Bifulco, Ersilia, additional, Menkissoglu-Spiroudi, Urania, additional, and Caboni, Pierluigi, additional

Published
2010
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43. Floral markers of strawberry tree (Arbutus unedo L.) honey.

Author

Tuberoso CI, Bifulco E, Caboni P, Cottiglia F, Cabras P, and Floris I

Subjects
Flowers chemistry, Homogentisic Acid analysis, Plant Nectar analysis, Biomarkers analysis, Ericaceae chemistry, Honey analysis, Plant Preparations analysis
Abstract

Strawberry tree honey, due to its characteristic bitter taste, is one of the most typical Mediterranean honeys, with Sardinia being one of the largest producers. According to specific chemical studies, homogentisic acid was identified as a possible marker of this honey. This work, based on HPLC-DAD-MS/MS analysis of strawberry tree (Arbutus unedo L.) honeys, previously selected by sensory evaluation and melissopalynological analysis, showed that, in addition to the above-mentioned acid, there were other high levels of substances useful for the botanical classification of this unifloral honey. Two of these compounds were isolated and identified as (+/-)-2-cis,4-trans-abscisic acid (c,t-ABA) and (+/-)-2-trans,4-trans-abscisic acid (t,t-ABA). A third compound, a new natural product named unedone, was characterized as an epoxidic derivative of the above-mentioned acids. Structures of c,t-ABA, t,t-ABA, and unedone were elucidated on the basis of extensive 1D and 2D NMR experiments, as well as HPLC-MS/MS and Q-TOF analysis. In selected honeys the average amounts of c,t-ABA, t,t-ABA, and unedone were 176.2+/-25.4, 162.3+/-21.1, and 32.9+/-7.1 mg/kg, respectively. Analysis of the A. unedo nectar confirmed the floral origin of these compounds found in the honey. Abscisic acids were found in other unifloral honeys but not in such high amount and with a constant ratio of about 1:1. For this reason, besides homogentisic acid, these compounds could be used as complementary markers of strawberry tree honey.

Published
2010
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