50 results on '"Biernawska, Jowita"'
Search Results
2. Cryoanalgesia as the Essential Element of Enhanced Recovery after Surgery (ERAS) in Children Undergoing Thoracic Surgery—Scoping Review
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Zacha, Sławomir, primary and Biernawska, Jowita, additional
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- 2024
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3. One- versus Two-Minute Intercostal Nerve Cryoanalgesia in Children Undergoing Surgery for Funnel Chest Deformity.
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Zacha, Sławomir, Lopez, Manuel, Bilas, Jarosław, Skonieczna-Żydecka, Karolina, Miegoń, Jakub, and Biernawska, Jowita
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INTERCOSTAL nerves ,PECTUS excavatum ,MINIMALLY invasive procedures ,COMBINED modality therapy ,PAIN measurement - Abstract
An inherent defect of the sternum and ribs results in the formation of a funnel-shaped anterior chest wall. The gold standard of surgical correction is the minimally invasive Nuss procedure, which might cause severe pain and carries the risk of sensory disturbances and chronic discomfort. Integrating cryoanalgesia with standard multimodal analgesia improves the outcomes of this procedure. Based on histological results, it was hypothesised that the time of cryo-application can be reduced from the current standard period of two minutes. The goal of this study was to evaluate the efficacy of a one-minute application compared with the routine two-minute method in the same patient, considering the subjective perception of pain and sensory disturbances. A total of 33 patients were included in this prospective study. The results show that the assessment of pain severity and sensory disturbances did not differ significantly in terms of the time of cryo-application during first 14 days after the surgical procedure. The one-minute cryo-application time for intraoperative intercostal nerve cryoablation prior to the Nuss procedure seems to be as safe and effective as the routinely used two-minute application time in regards to pain severity, sensory disturbances, and the risk of chronic pain development. Intercostal nerve cryoanalgesia is an essential element of multimodal analgesia. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Cryoanalgesia as Essential Component of PerioperativeMultimodal Analgesia in Pediatrics – Literature Review
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Zacha, Sławomir, primary, Miegoń, Jakub, additional, and Biernawska, Jowita, additional
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- 2024
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5. Predictors of outcomes of patients ≥ 80 years old admitted to intensive care units in Poland – a post-hoc analysis of the VIP2 prospective observational study
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Pasieka, Paweł Melchior, primary, Kurek, Michał, additional, Skupnik, Wojciech, additional, Skwara, Evan, additional, Bezshapkin, Valentyn, additional, Fronczek, Jakub, additional, Kluzik, Anna, additional, Kudliński, Bartosz, additional, Białka, Szymon, additional, Studzińska, Dorota, additional, Krzych, Łukasz, additional, Czajka, Szymon, additional, Stefaniak, Jan, additional, Owczuk, Radosław, additional, Sołek-Pastuszka, Joanna, additional, Biernawska, Jowita, additional, Zorska, Joanna, additional, Krawczyk, Paweł, additional, Cwyl, Katarzyna, additional, Żukowski, Maciej, additional, Kotfis, Katarzyna, additional, Zegan-Barańska, Małgorzata, additional, Wieczorek, Agnieszka, additional, Mudyna, Wojciech, additional, Piechota, Mariusz, additional, Bernas, Szymon, additional, Machała, Waldemar, additional, Sadowski, Łukasz, additional, Serwa, Marta, additional, Czuczwar, Mirosław, additional, Borys, Michał, additional, Ziętkiewicz, Mirosław, additional, Kozera, Natalia, additional, Adamik, Barbara, additional, Goździk, Waldemar, additional, Nasiłowski, Paweł, additional, Zatorski, Paweł, additional, Trzebicki, Janusz, additional, Gałkin, Piotr, additional, Gawda, Ryszard, additional, Kościuczuk, Urszula, additional, Cyrankiewicz, Waldemar, additional, Sierakowska, Katarzyna, additional, Gola, Wojciech, additional, Hymczak, Hubert, additional, Flaatten, Hans, additional, and Szczeklik, Wojciech, additional
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- 2024
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6. Clinical Consequences of Unreconstructed Pelvic Defect Caused by Osteosarcoma with Subsequent Progressive Scoliosis in a Pediatric Patient—Case Report.
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Zacha, Sławomir, Kotrych, Katarzyna, Zacha, Wojciech, Biernawska, Jowita, Ali, Arkadiusz, Ciechanowicz, Dawid, Ziętek, Paweł, and Kotrych, Daniel
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OSTEOSARCOMA ,MEDICAL information storage & retrieval systems ,PELVIC tumors ,COMPUTED tomography ,DISCHARGE planning ,SYSTEMATIC reviews ,MEDLINE ,OSTEOTOMY ,LITERATURE reviews ,ADOLESCENT idiopathic scoliosis ,ONLINE information services ,HEMIPELVECTOMY ,THREE-dimensional printing - Abstract
Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. The standard and most effective treatment is wide resection of the tumor combined with neoadjuvant chemotherapy. Adolescent idiopathic scoliosis (AIS) is a genetically determined three-dimensional spinal deformity, which occurs in teenage patients and is mostly progressive. The basic management strategy is surgical treatment when the curve exceeds 50 degrees. However, the indications are different in oncologic patients. The aim of this study was to describe a case of adolescent scoliosis with osteosarcoma of the pelvis. The authors conducted a scoping review using PubMed and Embase to analyze the state of knowledge. The presented paper is the first report of pelvis osteosarcoma coexisting with adolescent idiopathic scoliosis. Treatment for this complex case finished with very good results, with no recurrence observed during the nine-year follow-up. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Benefits of the Erector Spinae Plane Block before Cryoanalgesia in Children Undergoing Surgery for Funnel Chest Deformity
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Zacha, Sławomir, primary, Jarosz, Konrad, additional, Kokot, Karolina, additional, Biłas, Jarosław, additional, Skonieczna-Żydecka, Karolina, additional, Gerus, Sylwester, additional, Kojder, Klaudyna, additional, and Biernawska, Jowita, additional
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- 2023
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8. Krioanalgezja jako istotna część okołooperacyjnej analgezji multimodalnej u dzieci – przegląd literatury.
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Zacha, Sławomir, Miegoń, Jakub, and Biernawska, Jowita
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INTERCOSTAL nerves ,PEDIATRIC surgery ,CHRONIC pain ,HOSPITAL care ,COLD therapy ,ANALGESIA ,PEDIATRICS ,ENHANCED recovery after surgery protocol ,MOBILITY training ,PAIN management ,THORACOSCOPY ,PERIOPERATIVE care - Abstract
Copyright of Pain Research / Ból is the property of Index Copernicus International and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
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9. Novel Interdisciplinary Enhanced Recovery after Surgery Protocol Implementation in Paediatric Orthopaedics
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Zacha, Sławomir, primary, Szwed, Aleksander, additional, Miegoń, Jakub, additional, Skonieczna-Żydecka, Karolina, additional, Andrzejewska, Agata, additional, Modrzejewska, Elżbieta, additional, Horecki, Marcin, additional, Jarosz, Konrad, additional, and Biernawska, Jowita, additional
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- 2023
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10. EP219 Cryoanalgesia is an essential part of multimodal analgesia in the surgical treatment of funnel chest deformation
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Zacha, Sławomir, primary, Skonieczna-Żydecka, Karolina, additional, Jarosz, Konrad, additional, and Biernawska, Jowita, additional
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- 2023
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11. Optimising Intraoperative Fluid Management in Patients Treated with Adolescent Idiopathic Scoliosis—A Novel Strategy for Improving Outcomes
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Miegoń, Jakub, primary, Zacha, Sławomir, additional, Skonieczna-Żydecka, Karolina, additional, Wiczk-Bratkowska, Agata, additional, Andrzejewska, Agata, additional, Jarosz, Konrad, additional, Deptuła-Jarosz, Monika, additional, and Biernawska, Jowita, additional
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- 2023
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12. Comparison of Two Apnea Test Methods, Oxygen Insufflation and Continuous Positive Airway Pressure During Diagnosis of Brain Death: Final Report
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Solek-Pastuszka, Joanna, Biernawska, Jowita, Iwańczuk, Waldemar, Kojder, Klaudyna, Chelstowski, Kornel, Bohatyrewicz, Romuald, and Sawicki, Marcin
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- 2019
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13. Intercostal nerve cryoanalgesia in the treatment of pain in patients operated on by the modified Nuss method with the BackOnFeet application—a new strategy to improve outcomes
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Zacha, Sławomir, primary, Andrzejewska, Agata, additional, Jastrzębska-Ligocka, Barbara, additional, Szwed, Aleksander, additional, Modrzejewska, Elżbieta, additional, Zacha, Wojciech, additional, Skonieczna-Żydecka, Karolina, additional, Miegoń, Jakub, additional, Jarosz, Konrad, additional, and Biernawska, Jowita, additional
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- 2023
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14. The Impact of Intraoperative Haemodynamic Monitoring, Prediction of Hypotension and Goal-Directed Therapy on the Outcomes of Patients Treated with Posterior Fusion Due to Adolescent Idiopathic Scoliosis.
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Andrzejewska, Agata, Miegoń, Jakub, Zacha, Sławomir, Skonieczna-Żydecka, Karolina, Jarosz, Konrad, Zacha, Wojciech, and Biernawska, Jowita
- Subjects
ADOLESCENT idiopathic scoliosis ,SPINAL fusion ,INTRAOPERATIVE monitoring ,HYPOTENSION ,INTRAOPERATIVE care ,BLOOD pressure ,ENHANCED recovery after surgery protocol - Abstract
A prospective, single-centre, non-randomised, case–control study aimed to evaluate the effectiveness of intraoperative haemodynamic monitoring, prediction of hypotension and goal-directed therapy on the outcomes of patients undergoing posterior fusion for adolescent idiopathic scoliosis (AIS). The control group (n = 35, mean age: 15 years) received standard blood pressure control during surgery, while the intervention group (n = 24, mean age: 14 years) underwent minimally invasive haemodynamic monitoring and goal-directed therapy. The intervention group showed significantly shorter durations of hypotension (mean arterial pressure < 60 mmHg), reduced hospital stays and smaller decreases in post-surgery haemoglobin levels. Additionally, the intervention group experienced shorter times from the end of surgery to extubation. These findings suggest that incorporating targeted interventions during intraoperative care for AIS patients undergoing posterior fusion can lead to improved outcomes. [ABSTRACT FROM AUTHOR]
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- 2023
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15. Long-Term Consequences of Increased Activity of Urine Enzymes After Cardiac Surgery – A Prospective Observational Study
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Biernawska, Jowita, primary, Kotfis, Katarzyna, additional, Szymańska-Pasternak, Jolanta, additional, Bogacka, Anna, additional, and Bober, Joanna, additional
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- 2022
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16. Melatonin and the Brain–Heart Crosstalk in Neurocritically Ill Patients—From Molecular Action to Clinical Practice
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Bekała, Artur, primary, Płotek, Włodzimierz, additional, Siwicka-Gieroba, Dorota, additional, Sołek-Pastuszka, Joanna, additional, Bohatyrewicz, Romuald, additional, Biernawska, Jowita, additional, Kotfis, Katarzyna, additional, Bielacz, Magdalena, additional, Jaroszyński, Andrzej, additional, and Dabrowski, Wojciech, additional
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- 2022
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17. Atypical Pupil Reactions in Brain Dead Patients
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Sołek-Pastuszka, Joanna, primary, Zegan-Barańska, Małgorzata, additional, Biernawska, Jowita, additional, Sawicki, Marcin, additional, Iwańczuk, Waldemar, additional, Chełstowski, Kornel, additional, Bohatyrewicz, Romuald, additional, Dąbrowski, Wojciech, additional, and Kojder, Klaudyna, additional
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- 2021
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18. Changes in Subendocardial Viability Ratio in Traumatic Brain Injury Patients
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Siwicka-Gieroba, Dorota, primary, Robba, Chiara, additional, Poleszczuk, Jan, additional, Debowska, Malgorzata, additional, Waniewski, Jacek, additional, Badenes, Rafael, additional, Jaroszynski, Andrzej, additional, Piasek, Ewa, additional, Kotfis, Katarzyna, additional, Biernawska, Jowita, additional, and Dabrowski, Wojciech, additional
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- 2021
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19. Seafood Intake as a Method of Non-Communicable Diseases (NCD) Prevention in Adults
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Jamioł-Milc, Dominika, primary, Biernawska, Jowita, additional, Liput, Magdalena, additional, Stachowska, Laura, additional, and Domiszewski, Zdzisław, additional
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- 2021
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20. The impact of frailty on ICU and 30-day mortality and the level of care in very elderly patients (≥ 80 years)
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Flaatten, Hans, De Lange, Dylan W., Morandi, Alessandro, Andersen, Finn H., Artigas, Antonio, Bertolini, Guido, Boumendil, Ariane, Cecconi, Maurizio, Christensen, Steffen, Faraldi, Loredana, Fjølner, Jesper, Jung, Christian, Marsh, Brian, Moreno, Rui, Oeyen, Sandra, Öhman, Christina Agwald, Pinto, Bernardo Bollen, Soliman, Ivo W., Szczeklik, Wojciech, Valentin, Andreas, Watson, Ximena, Zaferidis, Tilemachos, Guidet, Bertrand, Schmutz, René, Wimmer, Franz, Eller, Philipp, Zotter, Klemens, Swinnen, Walter, De Buysscher, Pieter, De Neve, Nikolaas, Abraham, Paul, Fleury, Yvan, Schefold, Joerg C., Biskup, Ewelina, Taliadoros, Ioannis, Piza, Petr, Lauten, Alexander, Sacher, Anna Lena, Brenner, Thorsten, Franz, Marcus, Bloos, Frank, Ebelt, Henning, Schaller, Stefan J., Fuest, Kristina, Rabe, Christian, Dieck, Thorben, Steiner, Stephan, Graf, Tobias, Nia, Amir M., Janosi, Rolf Alexander, Meybohm, Patrick, Simon, Philipp, Utzolino, Stefan, Rahmel, Tim, Barth, Eberhard, Schuster, Michael, Dey, Nilanjan, Sølling, Christoffer, Rasmussen, Bodil Steen, Rodriguez, Enver, Rebollo, Sergio, Aguilar, Gerardo, Masdeu, Gaspar, Jaimes, Marián Irazábal, Prado Mira, Ángela, Bodi, Maria A., Barea Mendoza, Jesus A., López-Cuenca, Sonia, Homez Guzman, Marcela, Rico-Feijoo, Jesús, Ibarz, Mercedes, Trenado-Alvarez, Josep, Forceville, Xavier, Besch, Guillaume, Mentec, Herve, Michel, Philippe, Mateu, Philippe, Vettoretti, Lucie, Bourenne, Jeremy, Marin, Nathalie, Guillot, Max, Aissaoui, Naida, Goulenok, Cyril, Thieulot-Rolin, Nathalie, Messika, Jonathan, Lamhaut, Lionel, Charron, Cyril, Dempsey, Ged, Mathew, Shiju J., Raj, Ashok S., Grecu, Irina, Cupitt, Jason, Lawton, Tom, Clark, Richard, Popescu, Monica, Spittle, Nick, Faulkner, Maria, Cowton, Amanda, Elloway, Esme, Williams, Patricia, Reay, Michael, Chukkambotla, Srikanth, Kumar, Ravi, Al-Subaie, Nawaf, Kent, Linda, Tamm, Tiina, Kajtor, Istvan, Burns, Karen, Pugh, Richard, Ostermann, Marlies, Kam, Elisa, Bowyer, Helen, Smith, Neil, Templeton, Maie, Henning, Jeremy, Goffin, Kelly, Kapoor, Ritoo, Laha, Shondipon, Chilton, Phil, Khaliq, Waqas, Crayford, Alison, Coetzee, Samantha, Tait, Moira, Boultoukas, Evangelos, Stoker, Wendy, Gimenez, Marc, Pope, Alan, Camsooksai, Julie, Pogson, David, Quigley, Kate, Ritzema, Jenny, Hormis, Anil, Boulanger, Carole, Balasubramaniam, M., Vamplew, Luke, Burt, Karen, Martin, Daniel, Craig, Jayne, Prowle, John, Doyle, Nanci, Shelton, Jonathon, Scott, Carmen, Donnison, Phil, Shelton, Sarah, Frey, Christian, Ryan, Christine, Spray, Dominic, Barnes, Veronica, Barnes, Kerry, Furneval, Julie, Ridgway, Stephanie, Saha, Rajnish, Clark, Thomas, Wood, James, Bolger, Clare, Bassford, Christopher, Lewandowski, john, Zhao, Xiaobei, Humphreys, Sally, Dowling, Susan, Richardson, Neil, Burtenshaw, Andrew, Stevenson, Carl, Wilcock, Danielle, Aidoni, Zoi, Aloizos, Stavros, Tasioudis, Polychronis, Lampiri, Kleri, Zisopoulou, Vasiliki, Ifigenia, Ravani, Eymorfia, Pagaki, Angela, Anttoniou, Katsoulas, Theodoros A., Kyparissi, Aikaterini, Aikaterini, Kounougeri, Marinakis, George, Tsimpoukas, Fotios, Spyropoulou, Anastasia, Zygoulis, Paris, Hayes, Ivan, Kelly, Yvelynne, Westbrook, Andrew, Fitzpatrick, Gerry, Maheshwari, Darshana, Motherway, Catherine, Gupta, Manish, Gurjar, Mohan, Maji, Ismail M, Negri, Giovanni, Spadaro, Savino, Nattino, Giuseppe, Pedeferri, Matteo, Boscolo, Annalisa, Rossi, Simona, Rossi, Maurizio, Calicchio, Giuseppe, Cubattoli, Lucia, Di Lascio, Gabriella, Barbagallo, Maria, Berruto, Francesco, Codazzi, Daniela, Bottazzi, Andrea, Fumagalli, Paolo, Negro, Giancarlo, Lupi, Giuseppe, Savelli, Flavia, Vulcano, Giuseppe A., Fumagalli, Roberto, Marudi, Andrea, Lefons, Ugo, Lembo, Rita, Babini, Maria, Paggioro, Alessandra, Parrini, Vieri, Zaccaria, Maria, Clementi, Stefano, Gigliuto, Carmelo, Facondini, Francesca, Pastorini, Simonetta, Munaron, Susanna, Calamai, Italo, Bocchi, Anna, Brizio, Elisabetta, Adorni, Adele, Bocci, Maria Grazia, Cortegiani, Andrea, Casalicchio, Tiziana, Mellea, Serena, Graziani, Elia, Barattini, Massimo, van Dijk, I., van Lelyveld-Haas, L. E. M., Ramnarain, D., Jansen, Tim, Nooteboom, Fleur, van der Voort, Peter H. J., Dieperink, Willem, de Waard, Monique C., Bormans, Laura, Hahn, Michael, Kemmerer, Nicolai, Strietzel, Hans Frank, Fehrle, Lutz, Dybwik, Knut, Legernaes, Terje, Klepstad, Pål, Olaussen, Even Braut, Olsen, Knut Inge, Børresen, Ole Marius, Bjørsvik, Geir, Maini, Sameer, Czuczwar, Miroslaw, Krawczyk, Pawel, Ziętkiewicz, Mirosław, Nowak, Łukasz R., Kotfis, Katarzyna, Cwyl, Katarzyna, Gajdosz, Ryszard, Biernawska, Jowita, Grudzień, Paweł, Nasiłowski, Paweł, Popek, Natalia, Cyrankiewicz, Waldemar, Wnuk, Marek, Maciejewski, Dariusz, Studzińska, Dorota, Zukowski, Maciej, Bernas, Szymon, Serwa, Marta, Stefaniak, Jan, Pawel, Maciejewski, Szymkowiak, Malgorzata, Adamik, Barbara, Catorze, Nuno, Castelo Branco, Miguel, Barros, Inês, Barros, Nelson, Krystopchuk, Andriy, Honrado, Teresa, Sousa, Cristina, Munoz, Francisco, Rebelo, Marta, Gomes, Rui, Nunes, Jorge, Dias, Celeste, Fernandes, Ana Margarida, Petrisor, Cristina, Constantin, Bodolea, Belskiy, Vladislav, Boskholov, Boris, Kawati, Rafael, Sivik, Joakim, Nauska, Jessica, Smole, Daniel, Parenmark, Fredric, Lyrén, Johanna, Rockstroh, Katalin, Rydén, Sara, Spångfors, Martin, Strinnholm, Morten, Walther, Sten, De Geer, Lina, Nordlund, Peter, Pålsson, Staffan, Zetterquist, Harald, Nilsson, Annika, Thiringer, Karin, Jungner, Mårten, Bark, Björn, Nordling, Berit, Sköld, Hans, Brorsson, Camilla, Persson, Stefan, Bergström, Anna, Berkius, Johan, Holmström, Johanna, Yapici, Nihan, University of Bergen (UiB), Haukeland University Hospital, University Medical Center [Utrecht], CIBER de Epidemiología y Salud Pública (CIBERESP), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), St George’s University Hospitals, Aarhus University Hospital, Mater Misericordiae University Hospital (The Mater Hospital), NOVA Medical School - Faculdade de Ciências Médicas (NMS), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), Ghent University Hospital, Karolinska University Hospital [Stockholm], Hôpitaux Universitaires de Genève (HUG), Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Service de Réanimation Médicale [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Gestionnaire, Hal Sorbonne Université, Flaatten, H, De Lange, D, Morandi, A, Andersen, F, Artigas, A, Bertolini, G, Boumendil, A, Cecconi, M, Christensen, S, Faraldi, L, Fjolner, J, Jung, C, Marsh, B, Moreno, R, Oeyen, S, Ohman, C, Pinto, B, Soliman, I, Szczeklik, W, Valentin, A, Watson, X, Zaferidis, T, Guidet, B, Schmutz, R, Wimmer, F, Eller, P, Zotter, K, Swinnen, W, De Buysscher, P, De Neve, N, Abraham, P, Fleury, Y, Schefold, J, Biskup, E, Taliadoros, I, Piza, P, Lauten, A, Sacher, A, Brenner, T, Franz, M, Bloos, F, Ebelt, H, Schaller, S, Fuest, K, Rabe, C, Dieck, T, Steiner, S, Graf, T, Nia, A, Janosi, R, Meybohm, P, Simon, P, Utzolino, S, Rahmel, T, Barth, E, Schuster, M, Dey, N, Solling, C, Rasmussen, B, Rodriguez, E, Rebollo, S, Aguilar, G, Masdeu, G, Jaimes, M, Prado Mira, A, Bodi, M, Barea Mendoza, J, Lopez-Cuenca, S, Homez Guzman, M, Rico-Feijoo, J, Ibarz, M, Trenado-Alvarez, J, Forceville, X, Besch, G, Mentec, H, Michel, P, Mateu, P, Vettoretti, L, Bourenne, J, Marin, N, Guillot, M, Aissaoui, N, Goulenok, C, Thieulot-Rolin, N, Messika, J, Lamhaut, L, Charron, C, Dempsey, G, Mathew, S, Raj, A, Grecu, I, Cupitt, J, Lawton, T, Clark, R, Popescu, M, Spittle, N, Faulkner, M, Cowton, A, Elloway, E, Williams, P, Reay, M, Chukkambotla, S, Kumar, R, Al-Subaie, N, Kent, L, Tamm, T, Kajtor, I, Burns, K, Pugh, R, Ostermann, M, Kam, E, Bowyer, H, Smith, N, Templeton, M, Henning, J, Goffin, K, Kapoor, R, Laha, S, Chilton, P, Khaliq, W, Crayford, A, Coetzee, S, Tait, M, Boultoukas, E, Stoker, W, Gimenez, M, Pope, A, Camsooksai, J, Pogson, D, Quigley, K, Ritzema, J, Hormis, A, Boulanger, C, Balasubramaniam, M, Vamplew, L, Burt, K, Martin, D, Craig, J, Prowle, J, Doyle, N, Shelton, J, Scott, C, Donnison, P, Shelton, S, Frey, C, Ryan, C, Spray, D, Barnes, V, Barnes, K, Furneval, J, Ridgway, S, Saha, R, Clark, T, Wood, J, Bolger, C, Bassford, C, Lewandowski, J, Zhao, X, Humphreys, S, Dowling, S, Richardson, N, Burtenshaw, A, Stevenson, C, Wilcock, D, Aidoni, Z, Aloizos, S, Tasioudis, P, Lampiri, K, Zisopoulou, V, Ifigenia, R, Eymorfia, P, Angela, A, Katsoulas, T, Kyparissi, A, Aikaterini, K, Marinakis, G, Tsimpoukas, F, Spyropoulou, A, Zygoulis, P, Hayes, I, Kelly, Y, Westbrook, A, Fitzpatrick, G, Maheshwari, D, Motherway, C, Gupta, M, Gurjar, M, Maji, I, Negri, G, Spadaro, S, Nattino, G, Pedeferri, M, Boscolo, A, Rossi, S, Rossi, M, Calicchio, G, Cubattoli, L, Di Lascio, G, Barbagallo, M, Berruto, F, Codazzi, D, Bottazzi, A, Fumagalli, P, Negro, G, Lupi, G, Savelli, F, Vulcano, G, Fumagalli, R, Marudi, A, Lefons, U, Lembo, R, Babini, M, Paggioro, A, Parrini, V, Zaccaria, M, Clementi, S, Gigliuto, C, Facondini, F, Pastorini, S, Munaron, S, Calamai, I, Bocchi, A, Brizio, E, Adorni, A, Bocci, M, Cortegiani, A, Casalicchio, T, Mellea, S, Graziani, E, Barattini, M, van Dijk, I, van Lelyveld-Haas, L, Ramnarain, D, Jansen, T, Nooteboom, F, van der Voort, P, Dieperink, W, de Waard, M, Bormans, L, Hahn, M, Kemmerer, N, Strietzel, H, Fehrle, L, Dybwik, K, Legernaes, T, Klepstad, P, Olaussen, E, Olsen, K, Borresen, O, Bjorsvik, G, Maini, S, Czuczwar, M, Krawczyk, P, Zietkiewicz, M, Nowak, L, Kotfis, K, Cwyl, K, Gajdosz, R, Biernawska, J, Grudzien, P, Nasilowski, P, Popek, N, Cyrankiewicz, W, Wnuk, M, Maciejewski, D, Studzinska, D, Zukowski, M, Bernas, S, Serwa, M, Stefaniak, J, Pawel, M, Szymkowiak, M, Adamik, B, Catorze, N, Castelo Branco, M, Barros, I, Barros, N, Krystopchuk, A, Honrado, T, Sousa, C, Munoz, F, Rebelo, M, Gomes, R, Nunes, J, Dias, C, Fernandes, A, Petrisor, C, Constantin, B, Belskiy, V, Boskholov, B, Kawati, R, Sivik, J, Nauska, J, Smole, D, Parenmark, F, Lyren, J, Rockstroh, K, Ryden, S, Spangfors, M, Strinnholm, M, Walther, S, De Geer, L, Nordlund, P, Palsson, S, Zetterquist, H, Nilsson, A, Thiringer, K, Jungner, M, Bark, B, Nordling, B, Skold, H, Brorsson, C, Persson, S, Bergstrom, A, Berkius, J, Holmstrom, J, Yapici, N, Flaatten, Han, De Lange, Dylan W., Morandi, Alessandro, Andersen, Finn H., Artigas, Antonio, Bertolini, Guido, Boumendil, Ariane, Cecconi, Maurizio, Christensen, Steffen, Faraldi, Loredana, Fjølner, Jesper, Jung, Christian, Marsh, Brian, Moreno, Rui, Oeyen, Sandra, Öhman, Christina Agwald, Pinto, Bernardo Bollen, Soliman, Ivo W., Szczeklik, Wojciech, Valentin, Andrea, Watson, Ximena, Zaferidis, Tilemacho, Guidet, Bertrand, Schmutz, René, Wimmer, Franz, Eller, Philipp, Zotter, Klemen, Swinnen, Walter, De Buysscher, Pieter, De Neve, Nikolaa, Abraham, Paul, Fleury, Yvan, Schefold, Joerg C., Biskup, Ewelina, Taliadoros, Ioanni, Piza, Petr, Lauten, Alexander, Sacher, Anna Lena, Brenner, Thorsten, Franz, Marcu, Bloos, Frank, Ebelt, Henning, Schaller, Stefan J., Fuest, Kristina, Rabe, Christian, Dieck, Thorben, Steiner, Stephan, Graf, Tobia, Nia, Amir M., Janosi, Rolf Alexander, Meybohm, Patrick, Simon, Philipp, Utzolino, Stefan, Rahmel, Tim, Barth, Eberhard, Schuster, Michael, Dey, Nilanjan, Sølling, Christoffer, Rasmussen, Bodil Steen, Rodriguez, Enver, Rebollo, Sergio, Aguilar, Gerardo, Masdeu, Gaspar, Jaimes, Marián Irazábal, Prado Mira, Ángela, Bodi, Maria A., Barea Mendoza, Jesus A., López-Cuenca, Sonia, Homez Guzman, Marcela, Rico-Feijoo, Jesú, Ibarz, Mercede, Trenado-Alvarez, Josep, Forceville, Xavier, Besch, Guillaume, Mentec, Herve, Michel, Philippe, Mateu, Philippe, Vettoretti, Lucie, Bourenne, Jeremy, Marin, Nathalie, Guillot, Max, Aissaoui, Naida, Goulenok, Cyril, Thieulot-Rolin, Nathalie, Messika, Jonathan, Lamhaut, Lionel, Charron, Cyril, Dempsey, Ged, Mathew, Shiju J., Raj, Ashok S., Grecu, Irina, Cupitt, Jason, Lawton, Tom, Clark, Richard, Popescu, Monica, Spittle, Nick, Faulkner, Maria, Cowton, Amanda, Elloway, Esme, Williams, Patricia, Reay, Michael, Chukkambotla, Srikanth, Kumar, Ravi, Al-Subaie, Nawaf, Kent, Linda, Tamm, Tiina, Kajtor, Istvan, Burns, Karen, Pugh, Richard, Ostermann, Marlie, Kam, Elisa, Bowyer, Helen, Smith, Neil, Templeton, Maie, Henning, Jeremy, Goffin, Kelly, Kapoor, Ritoo, Laha, Shondipon, Chilton, Phil, Khaliq, Waqa, Crayford, Alison, Coetzee, Samantha, Tait, Moira, Boultoukas, Evangelo, Stoker, Wendy, Gimenez, Marc, Pope, Alan, Camsooksai, Julie, Pogson, David, Quigley, Kate, Ritzema, Jenny, Hormis, Anil, Boulanger, Carole, Balasubramaniam, M., Vamplew, Luke, Burt, Karen, Martin, Daniel, Craig, Jayne, Prowle, John, Doyle, Nanci, Shelton, Jonathon, Scott, Carmen, Donnison, Phil, Shelton, Sarah, Frey, Christian, Ryan, Christine, Spray, Dominic, Barnes, Veronica, Barnes, Kerry, Furneval, Julie, Ridgway, Stephanie, Saha, Rajnish, Clark, Thoma, Wood, Jame, Bolger, Clare, Bassford, Christopher, Lewandowski, john, Zhao, Xiaobei, Humphreys, Sally, Dowling, Susan, Richardson, Neil, Burtenshaw, Andrew, Stevenson, Carl, Wilcock, Danielle, Aidoni, Zoi, Aloizos, Stavro, Tasioudis, Polychroni, Lampiri, Kleri, Zisopoulou, Vasiliki, Ifigenia, Ravani, Eymorfia, Pagaki, Angela, Anttoniou, Katsoulas, Theodoros A., Kyparissi, Aikaterini, Aikaterini, Kounougeri, Marinakis, George, Tsimpoukas, Fotio, Spyropoulou, Anastasia, Zygoulis, Pari, Hayes, Ivan, Kelly, Yvelynne, Westbrook, Andrew, Fitzpatrick, Gerry, Maheshwari, Darshana, Motherway, Catherine, Gupta, Manish, Gurjar, Mohan, Maji, Ismail M, Negri, Giovanni, Spadaro, Savino, Nattino, Giuseppe, Pedeferri, Matteo, Boscolo, Annalisa, Rossi, Simona, Rossi, Maurizio, Calicchio, Giuseppe, Cubattoli, Lucia, Di Lascio, Gabriella, Barbagallo, Maria, Berruto, Francesco, Codazzi, Daniela, Bottazzi, Andrea, Fumagalli, Paolo, Negro, Giancarlo, Lupi, Giuseppe, Savelli, Flavia, Vulcano, Giuseppe A., Fumagalli, Roberto, Marudi, Andrea, Lefons, Ugo, Lembo, Rita, Babini, Maria, Paggioro, Alessandra, Parrini, Vieri, Zaccaria, Maria, Clementi, Stefano, Gigliuto, Carmelo, Facondini, Francesca, Pastorini, Simonetta, Munaron, Susanna, Calamai, Italo, Bocchi, Anna, Brizio, Elisabetta, Adorni, Adele, Bocci, Maria Grazia, Cortegiani, Andrea, Casalicchio, Tiziana, Mellea, Serena, Graziani, Elia, Barattini, Massimo, van Dijk, I., van Lelyveld-Haas, L.E.M., Ramnarain, D., Jansen, Tim, Nooteboom, Fleur, van der Voort, Peter H.J., Dieperink, Willem, de Waard, Monique C., Bormans, Laura, Hahn, Michael, Kemmerer, Nicolai, Strietzel, Hans Frank, Fehrle, Lutz, Dybwik, Knut, Legernaes, Terje, Klepstad, Pål, Olaussen, Even Braut, Olsen, Knut Inge, Børresen, Ole Mariu, Bjørsvik, Geir, Maini, Sameer, Czuczwar, Miroslaw, Krawczyk, Pawel, Ziętkiewicz, Mirosław, Nowak, Łukasz R., Kotfis, Katarzyna, Cwyl, Katarzyna, Gajdosz, Ryszard, Biernawska, Jowita, Grudzień, Paweł, Nasiłowski, Paweł, Popek, Natalia, Cyrankiewicz, Waldemar, Wnuk, Marek, Maciejewski, Dariusz, Studzińska, Dorota, Zukowski, Maciej, Bernas, Szymon, Serwa, Marta, Stefaniak, Jan, Pawel, Maciejewski, Szymkowiak, Malgorzata, Adamik, Barbara, Catorze, Nuno, Castelo Branco, Miguel, Barros, Inê, Barros, Nelson, Krystopchuk, Andriy, Honrado, Teresa, Sousa, Cristina, Munoz, Francisco, Rebelo, Marta, Gomes, Rui, Nunes, Jorge, Dias, Celeste, Fernandes, Ana Margarida, Petrisor, Cristina, Constantin, Bodolea, Belskiy, Vladislav, Boskholov, Bori, Kawati, Rafael, Sivik, Joakim, Nauska, Jessica, Smole, Daniel, Parenmark, Fredric, Lyrén, Johanna, Rockstroh, Katalin, Rydén, Sara, Spångfors, Martin, Strinnholm, Morten, Walther, Sten, De Geer, Lina, Nordlund, Peter, Pålsson, Staffan, Zetterquist, Harald, Nilsson, Annika, Thiringer, Karin, Jungner, Mårten, Bark, Björn, Nordling, Berit, Sköld, Han, Brorsson, Camilla, Persson, Stefan, Bergström, Anna, Berkius, Johan, Holmström, Johanna, and Yapici, Nihan
- Subjects
Male ,Time Factors ,Outcome Assessment ,Frail Elderly/statistics & numerical data ,[SDV]Life Sciences [q-bio] ,HSJ UCI ,Passive ,Critical Care and Intensive Care Medicine ,Frailty/classification/diagnosis/mortality/therapy ,Severity of Illness Index ,Severity of illne ,Elderly ,0302 clinical medicine ,Quality of life ,Frailty ,ICU ,Mortality ,Octogenarians ,Severity of illness ,Aged, 80 and over ,Critical Illness ,Europe ,Euthanasia, Passive ,Female ,Frail Elderly ,Geriatric Assessment ,Humans ,Intensive Care Units ,Length of Stay ,Outcome Assessment, Health Care ,Proportional Hazards Models ,Prospective Studies ,Quality of Life ,Hospital Mortality ,80 and over ,030212 general & internal medicine ,Prospective cohort study ,education.field_of_study ,ddc:617 ,Mortality rate ,[SDV] Life Sciences [q-bio] ,Length of Stay/statistics & numerical data ,Cohort ,Intensive Care Units/statistics & numerical data ,Critical Illne ,SOFA score ,Human ,medicine.medical_specialty ,Time Factor ,Intensive Care Unit ,Population ,INTENSIVE-CARE ,Europe/epidemiology ,Outcome Assessment (Health Care) ,03 medical and health sciences ,Octogenarian ,Intensive care ,Journal Article ,medicine ,COHORT ,Octogenarinans ,Intensive care medicine ,education ,Aged ,OLDER ,Euthanasia ,business.industry ,030208 emergency & critical care medicine ,Health Care ,Prospective Studie ,Critical Illness/mortality ,UNIT ,Emergency medicine ,Proportional Hazards Model ,business - Abstract
Purpose: Very old critical ill patients are a rapid expanding group in the ICU. Indications for admission, triage criteria and level of care are frequently discussed for such patients. However, most relevant outcome studies in this group frequently find an increased mortality and a reduced quality of life in survivors. The main objective was to study the impact of frailty compared with other variables with regards to short-term outcome in the very old ICU population. Methods: A transnational prospective cohort study from October 2016 to May 2017 with 30days follow-up was set up by the European Society of Intensive Care Medicine. In total 311 ICUs from 21 European countries participated. The ICUs included the first consecutive 20 very old (≥80years) patients admitted to the ICU within a 3-month inclusion period. Frailty, SOFA score and therapeutic procedures were registered, in addition to limitations of care. For measurement of frailty the Clinical Frailty Scale was used at ICU admission. The main outcomes were ICU and 30-day mortality and survival at 30days. Results: A total of 5021 patients with a median age of 84years (IQR 81–86years) were included in the final analysis, 2404 (47.9%) were women. Admission was classified as acute in 4215 (83.9%) of the patients. Overall ICU and 30-day mortality rates were 22.1% and 32.6%. During ICU stay 23.8% of the patients did not receive specific ICU procedures: ventilation, vasoactive drugs or renal replacement therapy. Frailty (values ≥5) was found in 43.1% and was independently related to 30-day survival (HR 1.54; 95% CI 1.38–1.73) for frail versus non-frail. Conclusions: Among very old patients (≥80years) admitted to the ICU, the consecutive classes in Clinical Frailty Scale were inversely associated with short-term survival. The scale had a very low number of missing data. These findings provide support to add frailty to the clinical assessment in this patient group. Trial registration: ClinicalTrials.gov (ID: NCT03134807).
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- 2017
21. COVID-19—The Potential Beneficial Therapeutic Effects of Spironolactone during SARS-CoV-2 Infection
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Kotfis, Katarzyna, primary, Lechowicz, Kacper, additional, Drożdżal, Sylwester, additional, Niedźwiedzka-Rystwej, Paulina, additional, Wojdacz, Tomasz K., additional, Grywalska, Ewelina, additional, Biernawska, Jowita, additional, Wiśniewska, Magda, additional, and Parczewski, Miłosz, additional
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- 2021
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22. Pregnancy complicated by Werner syndrome
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Sołek-Pastuszka, Joanna, Zagrodnik-Ułan, Edyta, Płonka, Tomasz, Wylot, Marcin, Biernawska, Jowita, Bohatyrewicz, Romuald, Kos, Władysław, Żukowski, Maciej, and Celewicz, Zbigniew
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- 2011
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23. COVID-19: The Potential Treatment of Pulmonary Fibrosis Associated with SARS-CoV-2 Infection
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Lechowicz, Kacper, primary, Drożdżal, Sylwester, additional, Machaj, Filip, additional, Rosik, Jakub, additional, Szostak, Bartosz, additional, Zegan-Barańska, Małgorzata, additional, Biernawska, Jowita, additional, Dabrowski, Wojciech, additional, Rotter, Iwona, additional, and Kotfis, Katarzyna, additional
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- 2020
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24. Cardiac Arrhythmias and Conduction Disturbances in Patients With Ankyiosing Spondylitis
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Kaźmierczak, Jaroslaw, Peregud-Pogorzelska, Malgorzata, Biernawska, Jowita, Przepiera-Bedzak, Hanna, Goracy, Jaroslaw, Brzosko, Iwona, Plonska, Edyta, and Brzosko, Marek
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- 2007
25. The Neutrophil/Lymphocyte Count Ratio Predicts Mortality in Severe Traumatic Brain Injury Patients
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Siwicka-Gieroba, Dorota, primary, Malodobry, Katarzyna, additional, Biernawska, Jowita, additional, Robba, Chiara, additional, Bohatyrewicz, Romuald, additional, Rola, Radoslaw, additional, and Dabrowski, Wojciech, additional
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- 2019
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26. Frailty increases mortality among patients ≥ 80 years old treated in Polish ICUs
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Fronczek, Jakub, primary, Polok, Kamil Jurand, additional, Nowak-Kózka, Ilona, additional, Włudarczyk, Anna, additional, Górka, Jacek, additional, Czuczwar, Mirosław, additional, Krawczyk, Paweł, additional, Ziętkiewicz, Mirosław, additional, Nowak, Łukasz R., additional, Żukowski, Maciej, additional, Kotfis, Katarzyna, additional, Cwyl, Katarzyna, additional, Gajdosz, Ryszard, additional, Bohatyrewicz, Romuald, additional, Biernawska, Jowita, additional, Grudzień, Paweł, additional, Nasiłowski, Paweł, additional, Popek, Natalia, additional, Cyrankiewicz, Waldemar, additional, Wawrzyniak, Katarzyna, additional, Wnuk, Marek, additional, Maciejewski, Dariusz, additional, Studzińska, Dorota, additional, Bernas, Szymon, additional, Piechota, Mariusz, additional, Machała, Waldemar, additional, Serwa, Marta, additional, Wujtewicz, Maria, additional, Stefaniak, Jan, additional, Szymkowiak, Małgorzata, additional, Gawda, Ryszard, additional, Adamik, Barbara, additional, Kozera, Natalia, additional, Goździk, Waldemar, additional, Flaatten, Hans, additional, and Szczeklik, Wojciech, additional
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- 2018
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27. Comparison of Two Apnea Test Methods, Oxygen Insufflation and Continuous Positive Airway Pressure During Diagnosis of Brain Death: Final Report
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Solek-Pastuszka, Joanna, primary, Biernawska, Jowita, additional, Iwańczuk, Waldemar, additional, Kojder, Klaudyna, additional, Chelstowski, Kornel, additional, Bohatyrewicz, Romuald, additional, and Sawicki, Marcin, additional
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- 2018
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28. Iron excretion in urine in patients with acute kidney injury after cardiac surgery
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Biernawska, Jowita, primary, Bober, Joanna, additional, Kotfis, Katarzyna, additional, Noceń, Iwona, additional, Bogacka, Anna, additional, Barnik, Edyta, additional, and Żukowski, Maciej, additional
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- 2018
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29. Predisposition of functional genetic variants of A-kinase anchoring protein 10 toward acquired repolarization disorders in high-risk vascular surgery patients
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Biernawska, Jowita, primary, Solek-Pastuszka, Joanna, additional, Kazimierczak, Arkadiusz, additional, Safranow, Krzysztof, additional, Kaczmarczyk, Mariusz, additional, Zegan-Baranska, Malgorzata, additional, Zukowski, Maciej, additional, and Kotfis, Katarzyna, additional
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- 2018
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30. Characteristics of peripheral immune cell subsets in patients with carotid atherosclerosis undergoing carotid endarterectomy
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Kotfis, Katarzyna, primary, Biernawska, Jowita, additional, Zegan-Barańska, Małgorzata, additional, Gutowski, Piotr, additional, and Żukowski, Maciej, additional
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- 2018
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31. Cardiac surgery related cardio-renal syndrome assessed by conventional and novel biomarkers – under or overestimated diagnosis?
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Biernawska, Jowita, primary, Bober, Joanna, additional, Kotfis, Katarzyna, additional, Bogacka, Anna, additional, Barnik, Edyta, additional, and Żukowski, Maciej, additional
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- 2017
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32. The influence of regional anaesthesia and local anaesthetics on cardiac repolarization
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Biernawska, Jowita, primary, Kaźmierczak, Jarosław, additional, Kotfis, Katarzyna, additional, and Żukowski, Maciej, additional
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- 2016
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33. Ocena EKG i parametrów holterowskich u pacjentów z zapaleniem wielomięśniowym i skórno-mięśniowym
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Peregud-Pogorzelska, Małgorzata, primary, Wielusiński, Maciej, additional, Bobrowska-Snarska, Danuta, additional, Biernawska, Jowita, additional, Zakrzewski, Marcin, additional, Brzosko, Marek, additional, Zieliński, Marek, additional, and Kaźmierczak, Jarosław, additional
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- 2015
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34. Peripheral Blood Lymphocyte Subsets (CD4+, CD8+ T Cells, NK Cells) in Patients with Cardiovascular and Neurological Complications after Carotid Endarterectomy
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Kotfis, Katarzyna, primary, Biernawska, Jowita, additional, Zegan-Barańska, Małgorzata, additional, and Żukowski, Maciej, additional
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- 2015
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35. Electrophysiological, Hemodynamic, and Metabolic Response to Open Procedure or Endovascular Repair of Infrarenal Aortic Aneurysms
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Biernawska, Jowita, primary, Kaczmarczyk, Mariusz, additional, Kotfis, Katarzyna, additional, Cnotliwy, Miłosław, additional, Zegan-Barańska, Małgorzata, additional, Żukowska, Agnieszka, additional, Greczan, Arkadiusz, additional, and Żukowski, Maciej, additional
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- 2014
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36. Original article Circulated CD4 + CD28 - lymphocytes rate and their cytotoxicity and morphological parameters of internal carotid artery atheromatous plaques in patients with atherosclerosis-related ischemic stroke
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Masztalewicz, Marta, primary, Nowacki, Przemysław, additional, Bajer-Czajkowska, Anna, additional, Kotfis, Katarzyna, additional, Biernawska, Jowita, additional, Safranow, Krzysztof, additional, Żukowski, Maciej, additional, and Gutowski, Piotr, additional
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- 2013
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37. Prevalence of life-sustaining treatment limitations in Polish very old intensive care patients (VIPs). A post-hoc analysis of two prospective observational studies
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Pasieka, Paweł, Surówka, Anna, Fronczek, Jakub, Skwara, Evan, Czuczwar, Mirosław, Borys, Michał, Krawczyk, Paweł, Ziętkiewicz, Mirosław, Nowak, Łukasz R., Żukowski, Maciej, Kotfis, Katarzyna, Cwyl, Katarzyna, Skowronek, Jacek, Solek-Pastuszka, Joanna, Biernawska, Jowita, Grudzień, Paweł, Nasiłowski, Paweł, Popek, Natalia, Cyrankiewicz, Waldemar, Sierakowska, Katarzyna, Mudyna, Wojciech, Białka, Szymon, Studzińska, Dorota, Bernas, Szymon, Piechota, Mariusz, Machała, Waldemar, Sadowski, Łukasz, Stefaniak, Jan, Owczuk, Radosław, Szymkowiak, Małgorzata, Gawda, Ryszard, Kozera, Natalia, Adamik, Barbara, Goździk, Waldemar, Wieczorek, Agnieszka, Janc, Jarosław, Kluzik, Anna, Trzebicki, Janusz, Zatorski, Paweł, Gola, Wojciech, Hymczak, Hubert, Krzych, Lukasz J., Czajka, Szymon, Kościuczuk, Urszula, Kudliński, Bartosz, Flaatten, Hans, and Szczeklik, Wojciech
- Abstract
Several initiatives have recently focused on raising awareness about limitations of treatment in Poland. We aimed to assess if the propensity to limit LST among elderly patients in 2018-2019 increased compared to 2016-2017.
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- 2023
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38. Association of the rs10918594 of Nitric Oxide Synthase 1 Adaptor Protein (NOS1AP) polymorphisms with the graft function after kidney transplantation
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Zukowski, Maciej, primary, Kotfis, Katarzyna, additional, Biernawska, Jowita, additional, Zegan-Baranska, Malgorzata, additional, Blaszczyk, Wojciech, additional, Kaczmarczyk, Mariusz, additional, Ciechanowicz, Andrzej, additional, Binczak-Kuleta, Agnieszka, additional, Brykczynski, Miroslaw, additional, Zietek, Zbigniew, additional, and Bohatyrewicz, Romuald, additional
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- 2011
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39. Factors influencing QTc interval prolongation during kidney transplantation
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Zukowski, Maciej, primary, Biernawska, Jowita, additional, Kotfis, Katarzyna, additional, Kaczmarczyk, Mariusz, additional, Bohatyrewicz, Romuald, additional, Blaszczyk, Wojciech, additional, Zegan-Baranska, Malgorzata, additional, Ostrowski, Marek, additional, Brykczynski, Miroslaw, additional, and Ciechanowicz, Andrzej, additional
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- 2011
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40. Pregnancy complicated by Werner syndrome
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Sołek-Pastuszka, Joanna, primary, Zagrodnik-Ułan, Edyta, additional, Płonka, Tomasz, additional, Wylot, Marcin, additional, Biernawska, Jowita, additional, Bohatyrewicz, Romuald, additional, Kos, Władysław, additional, Żukowski, Maciej, additional, and Celewicz, Zbigniew, additional
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- 2010
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41. Peripheral Blood Lymphocyte Subsets (CD4+, CD8+ T Cells, NK Cells) in Patients with Cardiovascular and Neurological Complications after Carotid Endarterectomy.
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Kotfis, Katarzyna, Biernawska, Jowita, Zegan-Barańska, Małgorzata, and Żukowski, Maciej
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ATHEROSCLEROTIC plaque , *CAROTID endarterectomy , *CD4 antigen , *CD8 antigen , *CARDIOVASCULAR diseases , *PATIENTS , *KILLER cells , *T cells , *THERAPEUTICS , *SURGICAL complications , *PHYSIOLOGY - Abstract
Background: The aim of the study was to evaluate the differences in the circulating immune cells' subgroups after the atherosclerotic plaque removal in patients presenting with postoperative complications as compared to the patients without complications after carotid endarterectomy (CEA). Methods: Patients with significant carotid atherosclerosis (n = 124, age range: 44 to 87 years) who underwent CEA were enrolled in a prospective study. The immunology study using flow cytometry was performed to determine the percentages of peripheral blood T cells (CD4+, CD8+, Treg--CD4+/CD25+) and NK (natural killer) cells before and after the procedure. The data were expressed as the percentage of total lymphocytes ± the standard error of mean. Results: The mean percentage of lymphocytes (61.54% ± 17.50% vs. 71.82% ± 9.68%, p = 0.030) and CD4 T lymphocytes (T helper, 38.13% ± 13.78% vs. 48.39% ± 10.24%, p = 0.027) was significantly lower six hours after CEA in patients with postoperative 30-day cardiovascular and neurological complications as compared to the group without complications. On the other hand the mean NK level in the group with complications was significantly higher (21.61% ± 9.00% vs. 15.80% ± 9.31%, p = 0.048). Conclusions: The results of this study suggest that after carotid endarterectomy the percentages of circulating immune cells subsets differ in patients with and without postoperative complications. [ABSTRACT FROM AUTHOR]
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- 2015
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42. Circulated CD4+CD28- lymphocytes rate and their cytotoxicity and morphological parameters of internal carotid artery atheromatous plaques in patients with atherosclerosis-related ischemic stroke.
- Author
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Masztalewicz, Marta, Nowacki, Przemysław, Bajer-Czajkowska, Anna, Kotfis, Katarzyna, Biernawska, Jowita, Safranow, Krzysztof, Żukowski, Maciej, and Gutowski, Piotr
- Abstract
Background: The question about the role of CD4
+ CD28- lymphocytes in the pathogenesis of atherosclerosis-related ischemic stroke is still open. Material and methods: The study included patients, who underwent endarterectomy of internal carotid arteries. The group consisted of patients after stroke and ones without previous stroke. The histopathologic examination of obtained plaques has been performed. The percentage of CD4+ CD28- lymphocytes in peripheral blood and their cytotoxicity has been assessed for each patient. Results: The global percentage of CD4+ CD28- lymphocytes in blood was higher in the group of patients with plaques where connective tissue fibers consisted significantly of collagen fibers. The cytotoxicity of analysed cells related to less plaques calcification and presence of cholesterol crystals in the plaque. A multifactor regression of dependent variable presented the last relationship above as a only strong. Conclusions: CD4+ CD28- cytotoxic lymphocytes seem to be involved in carotid atherosclerotic plaques development. Intraplaque cholesterol deposits may contribute to this process. [ABSTRACT FROM AUTHOR]- Published
- 2013
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43. Carotid atheromatous plaques' instability. Practical implication of morphologic assessment.
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Masztalewicz, Marta, Nowacki, Przemysław, Bajer-Czajkowska, Anna, Kotfis, Katarzyna, Biernawska, Jowita, Żukowski, Maciej, and Gutowski, Piotr
- Abstract
The only method giving the possibility of a thorough assessment of plaques instability, is a histologic examination. Three plaques categories were distinguished: unstable, potentially unstable and stable. The distribution of particular types of plaques was similar in symptomatic and asymptomatic patients. Over three quarters of lesions which could correspond to stable plaques in a macroscopic assessment, microscopically fulfilled the criteria for unstable or potentially unstable ones (the number of confirmed stable lesions vs the number of unconfirmed ones, 13 vs. 51 respectively, p < 0.0001). In a microscopic assessment made for all the plaques altogether, 52 plaques (58.4%) were considered unstable; 18 (20.2%) fulfilled the criteria for potentially unstable ones. The remaining 19 plaques (21.4%) were classified as plaques of stable structure. Unstable plaques constituted a significant majority (unstable vs potentially unstable and unstable vs. stable, p = 0.0006 and p = 0.0008 respectively). Due to the fact that majority of carotid atheromatous plaques appear to be unstable or potentially unstable because of the inflammation and related mechanisms, the role of the inflammatory-immunologic component of atherosclerosis should be used in prophylaxis of stroke and the new therapeutic concepts worked out. [ABSTRACT FROM AUTHOR]
- Published
- 2012
44. Perioperative factors influencing the mortality of elective abdominal aorta aneurysm repair
- Author
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Zukowski, Maciej, Biernawska, Jowita, Prof. Katarzyna Laura Kotfis, Kaczmarczyk, Mariusz, Bohatyrewicz, Romuald, Cnotliwy, Miloslaw, Solek-Pastuszka, Joanna, Brykczynski, Miroslaw, and Ciechanowicz, Andrzej
45. Withholding or withdrawing of life-sustaining therapy in older adults (≥ 80 years) admitted to the intensive care unit
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Guidet B., Flaatten H., Boumendil A., Morandi A., Andersen F. H., Artigas A., Bertolini G., Cecconi M., Christensen S., Faraldi L., Fjolner J., Jung C., Marsh B., Moreno R., Oeyen S., Ohman C. A., Pinto B. B., Soliman I. W., Szczeklik W., Valentin A., Watson X., Zafeiridis T., De Lange D. W., Schmutz R., Wimmer F., Eller P., Zotter K., De Buysscher P., De Neve N., Swinnen W., Abraham P., Hergafi L., Schefold J. C., Biskup E., Taliadoros I., Piza P., Lauten A., Sacher A. L., Brenner T., Franz M., Bloos F., Ebelt H., Schaller S. J., Fuest K., Rabe C., Dieck T., Steiner S., Graf T., Nia A. M., Janosi R. A., Simon P., Utzolino S., Rahmel T., Barth E., Schuster M., Dey N., Solling C., Rasmussen B. S., Rodriguez E., Rebollo S., Aguilar G., Masdeu G., Jaimes M. I., Mira A. P., Bodi M. A., Barea Mendoza J. A., Lopez-Cuenca S., Guzman M. H., Rico-Feijoo J., Ibarz M., Alvarez J. T., Forceville X., Besch G., Mentec H., Michel P., Mateu P., Vettoretti L., Bourenne J., Marin N., Guillot M., Aissaoui N., Goulenok C., Thieulot-Rolin N., Messika J., Lamhaut L., Charron C., Dempsey G., Mathew S. J., Raj A. S., Grecu I., Cupitt J., Lawton T., Clark R., Popescu M., Spittle N., Faulkner M., Cowton A., Elloway E., Williams P., Reay M., Chukkambotla S., Kumar R., Al-Subaie N., Kent L., Tamm T., Kajtor I., Burns K., Pugh R., Ostermann M., Kam E., Bowyer H., Smith N., Templeton M., Henning J., Goffin K., Kapoor R., Laha S., Chilton P., Khaliq W., Crayford A., Coetzee S., Tait M., Stoker W., Gimenez M., Pope A., Camsooksai J., Pogson D., Quigley K., Ritzema J., Hormis A., Boulanger C., Balasubramaniam M., Vamplew L., Burt K., Martin D., Craig J., Prowle J., Doyle N., Shelton J., Scott C., Donnison P., Shelton S., Frey C., Ryan C., Spray D., Barnes V., Barnes K., Ridgway S., Saha R., Clark T., Wood J., Bolger C., Bassford C., Lewandowski J., Zhao X., Humphreys S., Dowling S., Richardson N., Burtenshaw A., Stevenson C., Wilcock D., Aidoni Z., Aloizos S., Tasioudis P., Lampiri K., Zisopoulou V., Ravani I., Pagaki E., Antoniou A., Katsoulas T. A., Kounougeri A., Marinakis G., Tsimpoukas F., Spyropoulou A., Zygoulis P., Kyparissi A., Hayes I., Kelly Y., Westbrook A., Fitzpatrick G., Maheshwari D., Motherway C., Gupta M., Gurjar M., Maji I. M., Negri G., Spadaro S., Nattino G., Pedeferri M., Boscolo A., Rossi S., Calicchio G., Cubattoli L., Di Lascio G., Barbagallo M., Berruto F., Codazzi D., Bottazzi A., Fumagalli P., Negro G., Lupi G., Savelli F., Vulcano G. A., Fumagalli R., Marudi A., Lefons U., Lembo R., Babini M., Paggioro A., Parrini V., Zaccaria M., Clementi S., Gigliuto C., Facondini F., Pastorini S., Munaron S., Calamai I., Bocchi A., Adorni A., Bocci M. G., Cortegiani A., Casalicchio T., Mellea S., Graziani E., Barattini M., Brizio E., Rossi M., van Dijk I., van Lelyveld-Haas L. E. M., Ramnarain D., Jansen T., Nooteboom F., van der Voort P. H., de Lange D., Dieperink W., de Waard M. C., de Smet A. G. E., Bormans L., Dormans T., Hahn M., Kemmerer N., Strietzel H. F., Dybwik K., Legernaes T., Klepstad P., Olaussen E. B., Olsen K. I., Brresen O. M., Bjorsvik G., Maini S., Fehrle L., Czuczwar M., Krawczyk P., Zietkiewicz M., Nowak L. R., Kotfis K., Cwyl K., Gajdosz R., Biernawska J., Bohatyrewicz R., Gawda R., Grudzien P., Nasilowski P., Popek N., Cyrankiewicz W., Wawrzyniak K., Wnuk M., Maciejewski D., Studzinska D., Zukowski M., Bernas S., Piechota M., Nowak I., Fronczek J., Serwa M., Machala W., Stefaniak J., Wujtewicz M., Maciejewski P., Szymkowiak M., Adamik B., Catorze N., Branco M. C., Barros I., Barros N., Krystopchuk A., Honrado T., Sousa C., Munoz F., Rebelo M., Gomes R., Nunes J., Dias C., Fernandes A. M., Petrisor C., Constantin B., Belskiy V., Boskholov B., Kawati R., Sivik J., Nauska J., Smole D., Parenmark F., Lyren J., Rockstroh K., Ryden S., Spangfors M., Strinnholm M., Walther S., De Geer L., Nordlund P., Palsson S., Zetterquist H., Nilsson A., Thiringer K., Jungner M., Bark B., Nordling B., Skold H., Brorsson C., Persson S., Bergstrom A., Berkius J., Holmstrom J., Nalapko Y., Service de Réanimation Médicale [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Bergen (UiB), Haukeland University Hospital, Norwegian University of Science and Technology [Trondheim] (NTNU), Norwegian University of Science and Technology (NTNU), Centro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES), Universitat Autònoma de Barcelona (UAB), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), St George's, University of London, Aarhus University Hospital, Ghent University Hospital, Karolinska University Hospital [Stockholm], Hôpitaux Universitaires de Genève (HUG), University Medical Center [Utrecht], Utrecht University [Utrecht], Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Guidet, B, Flaatten, H, Boumendil, A, Morandi, A, Andersen, F, Artigas, A, Bertolini, G, Cecconi, M, Christensen, S, Faraldi, L, Fjolner, J, Jung, C, Marsh, B, Moreno, R, Oeyen, S, Ohman, C, Pinto, B, Soliman, I, Szczeklik, W, Valentin, A, Watson, X, Zafeiridis, T, De Lange, D, Schmutz, R, Wimmer, F, Eller, P, Zotter, K, De Buysscher, P, De Neve, N, Swinnen, W, Abraham, P, Hergafi, L, Schefold, J, Biskup, E, Taliadoros, I, Piza, P, Lauten, A, Sacher, A, Brenner, T, Franz, M, Bloos, F, Ebelt, H, Schaller, S, Fuest, K, Rabe, C, Dieck, T, Steiner, S, Graf, T, Nia, A, Janosi, R, Simon, P, Utzolino, S, Rahmel, T, Barth, E, Schuster, M, Dey, N, Solling, C, Rasmussen, B, Rodriguez, E, Rebollo, S, Aguilar, G, Masdeu, G, Jaimes, M, Mira, A, Bodi, M, Barea Mendoza, J, Lopez-Cuenca, S, Guzman, M, Rico-Feijoo, J, Ibarz, M, Alvarez, J, Forceville, X, Besch, G, Mentec, H, Michel, P, Mateu, P, Vettoretti, L, Bourenne, J, Marin, N, Guillot, M, Aissaoui, N, Goulenok, C, Thieulot-Rolin, N, Messika, J, Lamhaut, L, Charron, C, Dempsey, G, Mathew, S, Raj, A, Grecu, I, Cupitt, J, Lawton, T, Clark, R, Popescu, M, Spittle, N, Faulkner, M, Cowton, A, Elloway, E, Williams, P, Reay, M, Chukkambotla, S, Kumar, R, Al-Subaie, N, Kent, L, Tamm, T, Kajtor, I, Burns, K, Pugh, R, Ostermann, M, Kam, E, Bowyer, H, Smith, N, Templeton, M, Henning, J, Goffin, K, Kapoor, R, Laha, S, Chilton, P, Khaliq, W, Crayford, A, Coetzee, S, Tait, M, Stoker, W, Gimenez, M, Pope, A, Camsooksai, J, Pogson, D, Quigley, K, Ritzema, J, Hormis, A, Boulanger, C, Balasubramaniam, M, Vamplew, L, Burt, K, Martin, D, Craig, J, Prowle, J, Doyle, N, Shelton, J, Scott, C, Donnison, P, Shelton, S, Frey, C, Ryan, C, Spray, D, Barnes, V, Barnes, K, Ridgway, S, Saha, R, Clark, T, Wood, J, Bolger, C, Bassford, C, Lewandowski, J, Zhao, X, Humphreys, S, Dowling, S, Richardson, N, Burtenshaw, A, Stevenson, C, Wilcock, D, Aidoni, Z, Aloizos, S, Tasioudis, P, Lampiri, K, Zisopoulou, V, Ravani, I, Pagaki, E, Antoniou, A, Katsoulas, T, Kounougeri, A, Marinakis, G, Tsimpoukas, F, Spyropoulou, A, Zygoulis, P, Kyparissi, A, Hayes, I, Kelly, Y, Westbrook, A, Fitzpatrick, G, Maheshwari, D, Motherway, C, Gupta, M, Gurjar, M, Maji, I, Negri, G, Spadaro, S, Nattino, G, Pedeferri, M, Boscolo, A, Rossi, S, Calicchio, G, Cubattoli, L, Di Lascio, G, Barbagallo, M, Berruto, F, Codazzi, D, Bottazzi, A, Fumagalli, P, Negro, G, Lupi, G, Savelli, F, Vulcano, G, Fumagalli, R, Marudi, A, Lefons, U, Lembo, R, Babini, M, Paggioro, A, Parrini, V, Zaccaria, M, Clementi, S, Gigliuto, C, Facondini, F, Pastorini, S, Munaron, S, Calamai, I, Bocchi, A, Adorni, A, Bocci, M, Cortegiani, A, Casalicchio, T, Mellea, S, Graziani, E, Barattini, M, Brizio, E, Rossi, M, van Dijk, I, van Lelyveld-Haas, L, Ramnarain, D, Jansen, T, Nooteboom, F, van der Voort, P, de Lange, D, Dieperink, W, de Waard, M, de Smet, A, Bormans, L, Dormans, T, Hahn, M, Kemmerer, N, Strietzel, H, Dybwik, K, Legernaes, T, Klepstad, P, Olaussen, E, Olsen, K, Brresen, O, Bjorsvik, G, Maini, S, Fehrle, L, Czuczwar, M, Krawczyk, P, Zietkiewicz, M, Nowak, L, Kotfis, K, Cwyl, K, Gajdosz, R, Biernawska, J, Bohatyrewicz, R, Gawda, R, Grudzien, P, Nasilowski, P, Popek, N, Cyrankiewicz, W, Wawrzyniak, K, Wnuk, M, Maciejewski, D, Studzinska, D, Zukowski, M, Bernas, S, Piechota, M, Nowak, I, Fronczek, J, Serwa, M, Machala, W, Stefaniak, J, Wujtewicz, M, Maciejewski, P, Szymkowiak, M, Adamik, B, Catorze, N, Branco, M, Barros, I, Barros, N, Krystopchuk, A, Honrado, T, Sousa, C, Munoz, F, Rebelo, M, Gomes, R, Nunes, J, Dias, C, Fernandes, A, Petrisor, C, Constantin, B, Belskiy, V, Boskholov, B, Kawati, R, Sivik, J, Nauska, J, Smole, D, Parenmark, F, Lyren, J, Rockstroh, K, Ryden, S, Spangfors, M, Strinnholm, M, Walther, S, De Geer, L, Nordlund, P, Palsson, S, Zetterquist, H, Nilsson, A, Thiringer, K, Jungner, M, Bark, B, Nordling, B, Skold, H, Brorsson, C, Persson, S, Bergstrom, A, Berkius, J, Holmstrom, J, Nalapko, Y, Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), Guidet, Bertrand, Flaatten, Han, Boumendil, Ariane, Morandi, Alessandro, Andersen, Finn H., Artigas, Antonio, Bertolini, Guido, Cecconi, Maurizio, Christensen, Steffen, Faraldi, Loredana, Fjølner, Jesper, Jung, Christian, Marsh, Brian, Moreno, Rui, Oeyen, Sandra, Öhman, Christina Agwald, Pinto, Bernardo Bollen, Soliman, Ivo W., Szczeklik, Wojciech, Valentin, Andrea, Watson, Ximena, Zafeiridis, Tilemacho, de Lange, Dylan W., Schmutz, René, Wimmer, Franz, Eller, Philipp, Zotter, Klemen, de Buysscher, Pieter, de Neve, Nikolaa, Swinnen, Walter, Abraham, Paul, Hergafi, Leila, Schefold, Joerg C., Biskup, Ewelina, Taliadoros, Ioanni, Piza, Petr, Lauten, Alexander, Sacher, Anna Lena, Brenner, Thorsten, Franz, Marcu, Bloos, Frank, Ebelt, Henning, Schaller, Stefan J, Fuest, Kristina, Rabe, Christian, Dieck, Thorben, Steiner, Stephan, Graf, Tobia, Nia, Amir M, Janosi, Rolf Alexander, Simon, Philipp, Utzolino, Stefan, Rahmel, Tim, Barth, Eberhard, Schuster, Michael, Dey, Nilanjan, Sølling, Christoffer, Rasmussen, Bodil Steen, Rodriguez, Enver, Rebollo, Sergio, Aguilar, Gerardo, Masdeu, Gaspar, Jaimes, Marián Irazábal, Mira, Ángela Prado, Bodi, Maria A., Barea Mendoza, Jesus A., López-Cuenca, Sonia, Guzman, Marcela Homez, Rico-Feijoo, Jesú, Ibarz, Mercede, Alvarez, Josep Trenado, Forceville, Xavier, Besch, Guillaume, Mentec, Herve, Michel, Philippe, Mateu, Philippe, Vettoretti, Lucie, Bourenne, Jeremy, MARIN, Nathalie, Guillot, Max, Aissaoui, Naida, Goulenok, Cyril, Thieulot-Rolin, Nathalie, Messika, Jonathan, Lamhaut, Lionel, Charron, Cyril, Dempsey, Ged, Mathew, Shiju J, Raj, Ashok S, Grecu, Irina, Cupitt, Jason, Lawton, Tom, Clark, Richard, Popescu, Monica, Spittle, Nick, Faulkner, Maria, Cowton, Amanda, Elloway, Esme, Williams, Patricia, Reay, Michael, Chukkambotla, Srikanth, Kumar, Ravi, Al-Subaie, Nawaf, Kent, Linda, Tamm, Tiina, Kajtor, Istvan, Burns, Karen, Pugh, Richard, Ostermann, Marlie, Kam, Elisa, Bowyer, Helen, Smith, Neil, Templeton, Maie, Henning, Jeremy, Goffin, Kelly, Kapoor, Ritoo, Laha, Shondipon, Chilton, Phil, Khaliq, Waqa, Crayford, Alison, Coetzee, Samantha, Tait, Moira, Stoker, Wendy, Gimenez, Marc, Pope, Alan, Camsooksai, Julie, Pogson, David, Quigley, Kate, Ritzema, Jenny, Hormis, Anil, Boulanger, Carole, Balasubramaniam, M., Vamplew, Luke, Burt, Karen, Martin, Daniel, Craig, Jayne, Prowle, John, Doyle, Nanci, Shelton, Jonathon, Scott, Carmen, Donnison, Phil, Shelton, Sarah, Frey, Christian, Ryan, Christine, Spray, Dominic, Barnes, Veronica, Barnes, Kerry, Ridgway, Stephanie, Saha, Rajnish, Clark, Thoma, Wood, Jame, Bolger, Clare, Bassford, Christopher, Lewandowski, John, Zhao, Xiaobei, Humphreys, Sally, Dowling, Susan, Richardson, Neil, Burtenshaw, Andrew, Stevenson, Carl, Wilcock, Danielle, Aidoni, Zoi, Aloizos, Stavro, Tasioudis, Polychroni, Lampiri, Kleri, Zisopoulou, Vasiliki, Ravani, Ifigenia, Pagaki, Eumorfia, Antoniou, Angela, Katsoulas, Theodoros A., Kounougeri, Aikaterini, Marinakis, George, Tsimpoukas, Fotio, Spyropoulou, Anastasia, Zygoulis, Pari, Kyparissi, Aikaterini, Hayes, Ivan, Kelly, Yvelynne, Westbrook, Andrew, Fitzpatrick, Gerry, Maheshwari, Darshana, Motherway, Catherine, Gupta, Manish, Gurjar, Mohan, Maji, Ismail M, Negri, Giovanni, Spadaro, Savino, Nattino, Giuseppe, Pedeferri, Matteo, Boscolo, Annalisa, Rossi, Simona, Calicchio, Giuseppe, Cubattoli, Lucia, Di Lascio, Gabriella, Barbagallo, Maria, Berruto, Francesco, Codazzi, Daniela, Bottazzi, Andrea, Fumagalli, Paolo, Negro, Giancarlo, Lupi, Giuseppe, Savelli, Flavia, Vulcano, Giuseppe A., Fumagalli, Roberto, Marudi, Andrea, Lefons, Ugo, Lembo, Rita, Babini, Maria, Paggioro, Alessandra, Parrini, Vieri, Zaccaria, Maria, Clementi, Stefano, Gigliuto, Carmelo, Facondini, Francesca, Pastorini, Simonetta, Munaron, Susanna, Calamai, Italo, Bocchi, Anna, Adorni, Adele, Bocci, Maria Grazia, Cortegiani, Andrea, Casalicchio, Tiziana, Mellea, Serena, Graziani, Elia, Barattini, Massimo, Brizio, Elisabetta, Rossi, Maurizio, van Dijk, I., van Lelyveld-Haas, L.E.M., Ramnarain, D., Jansen, Tim, Nooteboom, Fleur, van der Voort, Peter HJ, de Lange, Dylan, Dieperink, Willem, de Waard, Monique C., de Smet, Annemarie G. E., Bormans, Laura, Dormans, Tom, Hahn, Michael, Kemmerer, Nicolai, Strietzel, Hans Frank, Dybwik, Knut, Legernaes, Terje, Klepstad, Pål, Olaussen, Even Braut, Olsen, Knut Inge, Brresen, Ole Mariu, Bjorsvik, Geir, Maini, Sameer, Fehrle, Lutz, Czuczwar, Miroslaw, Krawczyk, Pawel, Ziętkiewicz, Mirosław, Nowak, Łukasz R., Kotfis, Katarzyna, Cwyl, Katarzyna, Gajdosz, Ryszard, Biernawska, Jowita, Bohatyrewicz, Romuald, Gawda, Ryszard, Grudzień, Paweł, Nasiłowski, Paweł, Popek, Natalia, Cyrankiewicz, Waldemar, Wawrzyniak, Katarzyna, Wnuk, Marek, Maciejewski, Dariusz, Studzińska, Dorota, Żukowski, Maciej, Bernas, Szymon, Piechota, Mariusz, Nowak, Ilona, Fronczek, Jakub, Serwa, Marta, Machała, Waldemar, Stefaniak, Jan, Wujtewicz, Maria, Maciejewski, Paweł, Szymkowiak, Małgorzata, Adamik, Barbara, Catorze, Nuno, Branco, Miguel Castelo, Barros, Inê, Barros, Nelson, Krystopchuk, Andriy, Honrado, Teresa, Sousa, Cristina, Munoz, Francisco, Rebelo, Marta, Gomes, Rui, Nunes, Jorge, Dias, Celeste, Fernandes, Ana Margarida, Petrisor, Cristina, Constantin, Bodolea, Belskiy, Vladislav, Boskholov, Bori, Kawati, Rafael, Sivik, Joakim, Nauska, Jessica, Smole, Daniel, Parenmark, Fredric, Lyrén, Johanna, Rockstroh, Katalin, Rydén, Sara, Spångfors, Martin, Strinnholm, Morten, Walther, Sten, de Geer, Lina, Nordlund, Peter, Pålsson, Staffan, Zetterquist, Harald, Nilsson, Annika, Thiringer, Karin, Jungner, Mårten, Bark, Björn, Nordling, Berit, Sköld, Han, Brorsson, Camilla, Persson, Stefan, Bergström, Anna, Berkius, Johan, Holmström, Johanna, Nalapko, Yuiry, and Critical Care
- Subjects
Male ,medicine.medical_treatment ,HSJ UCI ,Critical Care and Intensive Care Medicine ,law.invention ,Life sustaining treatment ,0302 clinical medicine ,Elderly ,law ,80 and over ,Medicine ,030212 general & internal medicine ,Prospective Studies ,Prospective cohort study ,Aged, 80 and over ,education.field_of_study ,Withholding Treatment ,ddc:617 ,[SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology ,Withholding ,Intensive care unit ,3. Good health ,Europe ,aged ,Intensive Care Units ,Withdrawal ,SOFA score ,Human ,medicine.medical_specialty ,ethical aspects ,Population ,Intensive Care Unit ,Decision Making ,Ethics ,Intensive care ,life-sustaining therapy ,NO ,03 medical and health sciences ,Anesthesiology ,Humans ,Ethic ,education ,Mechanical ventilation ,business.industry ,030208 emergency & critical care medicine ,critical care ,Life Support Care ,Prospective Studie ,Emergency medicine ,business - Abstract
PURPOSE: To document and analyse the decision to withhold or withdraw life-sustaining treatment (LST) in a population of very old patients admitted to the ICU. METHODS: This prospective study included intensive care patients aged ≥ 80 years in 309 ICUs from 21 European countries with 30-day mortality follow-up. RESULTS: LST limitation was identified in 1356/5021 (27.2%) of patients: 15% had a withholding decision and 12.2% a withdrawal decision (including those with a previous withholding decision). Patients with LST limitation were older, more frail, more severely ill and less frequently electively admitted. Patients with withdrawal of LST were more frequently male and had a longer ICU length of stay. The ICU and 30-day mortality were, respectively, 29.1 and 53.1% in the withholding group and 82.2% and 93.1% in the withdrawal group. LST was less frequently limited in eastern and southern European countries than in northern Europe. The patient-independent factors associated with LST limitation were: acute ICU admission (OR 5.77, 95% CI 4.32-7.7), Clinical Frailty Scale (CFS) score (OR 2.08, 95% CI 1.78-2.42), increased age (each 5 years of increase in age had a OR of 1.22 (95% CI 1.12-1.34) and SOFA score [OR of 1.07 (95% CI 1.05-1.09 per point)]. The frequency of LST limitation was higher in countries with high GDP and was lower in religious countries. CONCLUSIONS: The most important patient variables associated with the instigation of LST limitation were acute admission, frailty, age, admission SOFA score and country. TRIAL REGISTRATION: ClinicalTrials.gov (ID: NTC03134807). info:eu-repo/semantics/publishedVersion
- Published
- 2018
46. Characteristics of peripheral immune cell subsets in patients with carotid atherosclerosis undergoing carotid endarterectomy.
- Author
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Kotfis K, Biernawska J, Zegan-Barańska M, Gutowski P, and Żukowski M
- Abstract
Introduction: The role of circulating immune cells in the pathophysiology of cerebrovascular accidents is currently under debate. The aim of this study was to characterize peripheral immune cell subsets in patients undergoing carotid endarterectomy (CEA)., Material and Methods: We conducted a prospective observational study in a group of 124 patients with significant carotid stenosis undergoing carotid endarterectomy, both symptomatic and asymptomatic. We compared the percentages of circulating immune cells: B lymphocytes, T lymphocytes, T helper, cytotoxic T, CD4+/CD8+ ratio, T regulatory, monocytes and NK cells before CEA and 6 h after the procedure., Results: Total lymphocyte count and cytotoxic T lymphocyte count decreased 6 h after CEA in both subgroups. The NK cell level decrease was statistically significant only in the symptomatic subgroup (19.41 ±9.30 before CEA and 16.52 ±9.37 after CEA; p = 0.0044), but not in the asymptomatic subgroup (17.88 ±9.14 before CEA and 15.91 ±9.51 after CEA; p = 0.0886). The T lymphocyte level showed a statistically significant increase only in symptomatic patients (69.74 ±10.16 before CEA vs. 71.45 ±9.77 after CEA; p = 0.0462), and not in the asymptomatic subgroup (70.08 ±11.19 prior to CEA and 70.21 ±12.35; p = 0.9048). B lymphocyte, helper T lymphocyte and regulatory T (Treg) lymphocyte (CD4+/CD25+) levels showed a significant increase after CEA., Conclusions: This is the first study to compare circulating immune cells in patients undergoing carotid endarterectomy. Only the symptomatic subgroup experienced a significant decrease in the NK cell level and an increase in the T lymphocyte count after CEA. This study enriches our understanding of immune cell kinetics during carotid endarterectomy., Competing Interests: The authors declare no conflict of interest.
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- 2018
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47. Frailty is associated with an increased mortality among patients ≥ 80 years old treated in Polish ICUs
- Author
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Fronczek J, Polok KJ, Nowak-Kózka I, Włudarczyk A, Górka J, Czuczwar M, Krawczyk P, Ziętkiewicz M, Nowak ŁR, Żukowski M, Kotfis K, Cwyl K, Gajdosz R, Bohatyrewicz R, Biernawska J, Grudzień P, Nasiłowski P, Popek N, Cyrankiewicz W, Wawrzyniak K, Wnuk M, Maciejewski D, Studzińska D, Bernas S, Piechota M, Machała W, Serwa M, Wujtewicz M, Stefaniak J, Szymkowiak M, Gawda R, Adamik B, Kozera N, Goździk W, Flaatten H, and Szczeklik W
- Subjects
- Aged, 80 and over, Cohort Studies, Female, Humans, Length of Stay, Logistic Models, Male, Frailty, Hospital Mortality, Intensive Care Units
- Abstract
Background: The increasing population of very old intensive care patients (VIPs) is a major challenge currently faced by clinicians and policymakers. Reliable indicators of VIPs' prognosis and purposefulness of their admission to the intensive care unit (ICU) are urgently needed., Methods: This is a report from the Polish sample of the VIP1 multicentre cohort study (NCT03134807). Patients ≥ 80 years of age admitted to the ICU were included in the study. Information on the type and reason for admission, demographics, utilisation of ICU procedures, ICU length of stay, organ dysfunction and the decision to apply end-of-life care was collected. The primary objective was to investigate the impact of frailty syndrome on ICU and 30-day survival of VIPs. Frailty was assessed with the Clinical Frailty Scale (≥ 5 points on a scale of 1-9)., Results: We enrolled 272 participants with a median age of 84 (81-87) years. Frailty was diagnosed in 170 (62.5%) patients. The ICU and 30-day survival rates were equal to 54.6% and 47.3% respectively. Three variables were found to significantly increase the odds of death in the ICU in a multiple logistic regression model: SOFA score (OR = 1.16; 95%CI 1.16-1.24), acute mode of admission (OR = 5.1; 95%CI 1.67-15.57) and frailty (OR = 2.25; 95%CI 1.26-4.01)., Conclusion: Measuring frailty in critically ill older adults can facilitate making more informed clinical decisions and help avoid futile interventions.
- Published
- 2018
- Full Text
- View/download PDF
48. Circulated CD4+CD28- lymphocytes rate and their cytotoxicity and morphological parameters of internal carotid artery atheromatous plaques in patients with atherosclerosis-related ischemic stroke.
- Author
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Masztalewicz M, Nowacki P, Bajer-Czajkowska A, Kotfis K, Biernawska J, Safranow K, Żukowski M, and Gutowski P
- Subjects
- Adult, Aged, Aged, 80 and over, Atherosclerosis complications, Atherosclerosis immunology, Atherosclerosis pathology, CD28 Antigens immunology, Carotid Artery Diseases blood, Carotid Artery Diseases immunology, Carotid Artery, Internal pathology, Female, Flow Cytometry, Humans, Male, Middle Aged, Plaque, Atherosclerotic blood, Plaque, Atherosclerotic immunology, Stroke complications, Stroke pathology, T-Lymphocyte Subsets immunology, CD4-Positive T-Lymphocytes immunology, Carotid Artery Diseases pathology, Plaque, Atherosclerotic pathology, Stroke immunology
- Abstract
Background: The question about the role of CD4+CD28- lymphocytes in the pathogenesis of atherosclerosis-related ischemic stroke is still open., Material and Methods: The study included patients, who underwent endarterectomy of internal carotid arteries. The group consisted of patients after stroke and ones without previous stroke. The histopathologic examination of obtained plaques has been performed. The percentage of CD4+CD28- lymphocytes in peripheral blood and their cytotoxicity has been assessed for each patient., Results: The global percentage of CD4+CD28- lymphocytes in blood was higher in the group of patients with plaques where connective tissue fibers consisted significantly of collagen fibers. The cytotoxicity of analysed cells related to less plaques calcification and presence of cholesterol crystals in the plaque. A multifactor regression of dependent variable presented the last relationship above as a only strong., Conclusions: CD4+CD28- cytotoxic lymphocytes seem to be involved in carotid atherosclerotic plaques development. Intraplaque cholesterol deposits may contribute to this process.
- Published
- 2013
- Full Text
- View/download PDF
49. [Cefepim in empiric therapy of ventilator-associated pneumonia].
- Author
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Biernawska J, Zukowski M, Zegan-Barańska M, and Zukowska A
- Subjects
- Aged, Cefepime, Coronary Artery Bypass adverse effects, Diabetes Mellitus, Type 2 complications, Female, Heart Aneurysm complications, Heart Aneurysm surgery, Humans, Hypertension complications, Pneumonia, Ventilator-Associated diagnostic imaging, Pneumonia, Ventilator-Associated etiology, Radiography, Venous Insufficiency complications, Anti-Bacterial Agents therapeutic use, Cephalosporins therapeutic use, Pneumonia, Ventilator-Associated drug therapy
- Abstract
Background: The most common infection following surgical treatment, when mechanical ventilation and tracheal intubation are used, is ventilator-associated pneumonia (VAP) induced by Gram-negative and Gram-positive bacteria. Its treatment is difficult due to increasingly high antimicrobial drug resistance observed recently., Case Report: A 73-year-old patient was admitted to undergo coronary artery bypass grafting and cardiac aneurysm excision. Additionally, chronic circulatory insufficiency (NYHA 2) with ejection fraction of 30% together with hypertension and type 2 diabetes were diagnosed. After extracorporeal circulation, she was given adrenaline/noradrenaline and intra-aortic balloon pump. Postoperatively, elevated levels of CRP (70 mg L(-1)) and of procalcitonin (22.4 ng mL(-1)) were detected. Empiric therapy with cefepime 1 g x 2 iv was started. X-ray revealed atelectasis in the middle left lung lobe and Enterobacter cloacae was isolated from the bronchial tree. Patient was intubated and mechanically ventilated. Antibiotic therapy with cefepime was continued for 10 days and resulted in improvement of patient's general condition. On postoperative day 7, she was transferred from ITU to the cardiac surgery ward., Conclusion: Cefepime applied empirically to a VAP patient can effectively treat the lung infection and improve his/her general condition.
- Published
- 2009
50. Hospital readmission in patients with implantable cardioverter-defibrillators.
- Author
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Kaźmierczak J, Zielonka J, Rzeuski R, Peregud-Pogorzelska M, Goracy J, Biernawska J, Sulikowski T, and Kornacewicz-Jach Z
- Subjects
- Adult, Aged, Equipment Failure statistics & numerical data, Female, Follow-Up Studies, Hospitalization, Humans, Male, Middle Aged, Poland, Prognosis, Prospective Studies, Treatment Outcome, Arrhythmias, Cardiac therapy, Defibrillators, Implantable statistics & numerical data, Electric Countershock instrumentation, Patient Readmission statistics & numerical data
- Abstract
Introduction: Hospital readmissions are one of the important problems of patients with implantable cardioverter-defibrillators (ICD). Detailed analysis of the causes of re-hospitalizations may lead to improved management of ICD patients and eventually limit the number of hospital readmissions., Aim: Prospective analysis of repeat hospitalisations, their causes and time from discharge to first hospital readmission in a group of patients after ICD implantation. A search for predictors of rehospitalisation was also performed., Methods: Analysis involved 133 consecutive patients who underwent ICD implantation in the Department of Cardiology, PAM. Readmission causes were split into cardiac and non-cardiac. An index of repeat hospitalisation was calculated and parameters with a direct impact on rehospitalisation necessity were also evaluated., Results: One hundred and sixty-seven hospital readmissions of 72 (54%) patients were noted at mean 22+/-15 months after the primary hospitalisation. Rehospitalisation index per patient for the total follow-up period was 1.26, while for the first year of follow-up it was 0.69. In the case of 42 (32%) patients, 91 (54.5%) hospital readmissions were associated with arrhythmia. In 34 (25.6%) patients, 54 (32.3%) re-hospitalizations were not related to arrhythmia, while 20 (15%) patients were hospitalised 22 times (13.2%) for non-cardiac reasons. Mean time to the first readmission, regardless of the reason, was 9+/-9 months. Predominant causes of repeat hospitalisation were ventricular arrhythmias and worsening of heart failure. Patients with left ventricular ejection fraction (LVEF) below 30% and in functional NYHA class III were readmitted to hospital more frequently for reasons not related to arrhythmia., Conclusions: Hospital readmissions for cardiac causes in patients after ICD implantation are still frequent. Most of them are caused by ventricular arrhythmia and heart failure. Low LVEF (<30%) and NYHA functional class > or =III are risk factors predicting repeat hospitalisations unrelated to arrhythmia.
- Published
- 2006
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