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16 results on '"Bienvenu, Francoise"'

6. Insights into the Allergenic Potential of the Edible Yellow Mealworm (Tenebrio molitor)

Author

Barre, Annick, Pichereaux, Carole, Velazquez, Esmeralda, Maudouit, Agathe, Simplicien, Mathias, Garnier, Lorna, Bienvenu, Francoise, Bienvenu, Jacques, Burlet-Schiltz, Odile, Auriol, Cedric, Benoist, Hervé, Rougé, Pierre, Pharmacochimie et Biologie pour le Développement (PHARMA-DEV), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Institut de Recherche pour le Développement (IRD), Institut de pharmacologie et de biologie structurale (IPBS), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Service d'immunologie [Centre Hospitalier Lyon Sud - HCL], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Micronutris, ANR-10-INBS-0008,ProFI,Infrastructure Française de Protéomique(2010), Institut de Recherche pour le Développement (IRD)-Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), and Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)

Subjects
food allergy, in vitro degranulation test, yellow mealworm, arthropods, lcsh:Chemical technology, Tenebrio molitor, Article, allergenicity, immunoglobulin E cross-reacting allergens, lcsh:TP1-1185, [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, allergen, mass spectrometry
Abstract

The edible yellow mealworm (Tenebrio molitor), contains an extremely diverse panel of soluble proteins, including proteins with structural functions such as muscle proteins, as well as proteins involved in metabolic functions such as enzymes. Most of these proteins display a more or less pronounced allergenic character toward previously sensitized people, especially people allergic to shrimps and other shellfish. A mass spectrometry approach following the separation of a mealworm protein, extracted by sodiumdodecyl sulfate-polyacrylamide gel electrophoresis, allowed us to identify up to 106 distinct protein fractions including molecules with structural and functional functions, susceptible to developing an allergenic potential due to the possibility of immunoglobulin E-binding cross-reactions with their counterparts occurring in shellfish. In this respect, most of the sera from people allergic to shrimps reacted with the mealworm protein extract in Western blot experiments. Moreover, the potential mealworm allergens triggered the in vitro degranulation of rat leukemic basophils transfected with the human high-affinity IgE receptor (Fc&epsilon, RI), upon sensitization by the IgE-containing sera from people allergic to shrimps and other shellfish foods. Owing to the large repertoire of IgE-binding cross-reacting allergens the yellow mealworm shares with other phylogenetically-related groups of arthropods, it would seem prudent to inform the consumers, especially those allergic to shellfish, by appropriate labeling on edible mealworm packages about the potential risk of developing an allergic reaction.

Published
2019

11. The temporal relationship between the onset of type 1 diabetes and celiac disease: a study based on immunoglobulin a antitransglutaminase screening

Author

Peretti, Noel, Bienvenu, Francoise, Bouvet, Charlotte, Fabien, Nicole, Tixier, Frederique, Thivolet, Charles, Levy, Emile, Chatelain, Pierre G., Lachaux, Alain, and Nicolino, Marc

Subjects
Immunoglobulin A -- Testing, Celiac disease -- Risk factors, Celiac disease -- Diagnosis, Type 1 diabetes -- Complications, Type 1 diabetes -- Diagnosis
Abstract

Objective. The association of celiac disease (CD) and type 1 diabetes is now clearly documented. Immunoglobulin A (IgA) antitransglutaminase antibodies were measured to determine the prevalence of celiac disease in a diabetic population of children and to determine the temporal relationship between type 1 diabetes onset and CD. Methods. We measured IgA antitransglutaminase antibodies using human recombinant antigen in parallel with classical markers (IgA and IgG antigliadin, IgA antiendomysium) in 284 children with diabetes. Results. In the population studied, the prevalence of CD was 3.9% (11 of 284). Two cases of CD were diagnosed before the onset of diabetes, and in 8 patients, the diagnoses of CD and diabetes were concomitant, suggesting that CD was present before the onset of diabetes. In 1 case, a girl who presented with thyroiditis, serology for CD became positive after diabetes had been diagnosed. Conclusion. An excellent correlation was observed between IgA antiendomysium and IgA antitransglutaminase antibodies. We therefore propose using IgA antitransglutaminase as a screening test for practical reasons. Furthermore, IgA antitransglutaminase levels and mucosa abnormalities were closely correlated. The presence of antitransglutaminase antibodies should alert pediatricians to the atypical forms of CD. This study indicates that CD is most often present before the onset of diabetes. Pediatrics 2004;113:e418-e422. URL: http: //www.pediatrics.org/cgi/content/full/113/5/e418; celiac disease, type 1 diabetes, children, screening test, antitransglutaminase autoantibodies, prevalence, autoimmune diseases.

Published
2004

12. PII: S2213-2198(13)00380-2

Author

Rouzaire, Paul, Nosbaum, Audrey, Mullet, Christine, Diot, Nathalie, Dubost, Rolande, Bienvenu, Françoise, Guilloux, Laurence, Piriou, Vincent, Bienvenu, Jacques, and Bérard, Frédéric

Published
2013
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