100 results on '"Bielen D"'
Search Results
2. Non-Invasive Imaging Techniques for Diagnosis of Pelvic Deep Endometriosis and Endometriosis Classification Systems: An International Consensus Statement
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Condous, G., primary, Gerges, B., additional, Thomassin-Naggara, I., additional, Becker, C., additional, Tomassetti, C., additional, Krentel, H., additional, van Herendael, B.J., additional, Malzoni, M., additional, Abrao, M.S., additional, Saridogan, E., additional, Keckstein, J., additional, Hudelist, G., additional, Aas-Eng, K., additional, Alcazar, J.L., additional, Bafort, C., additional, Bazot, M., additional, Bielen, D., additional, Bokor, A., additional, Bourne, T., additional, Carmona, F., additional, Di Giovanni, A., additional, Djokovic, D., additional, Egekvist, A., additional, English, J., additional, Exacoustos, C., additional, Ferreira, H., additional, Ferrero, S., additional, Forstner, R., additional, Freeman, S., additional, Goncalves, M., additional, Grimbizis, G., additional, Guerra, A., additional, Guerriero, S., additional, Jansen, F.W., additional, Jurkovic, D., additional, Khazali, S., additional, Leonardi, M., additional, Maciel, C., additional, Manganaro, L., additional, Mueller, M., additional, Nisolle, M., additional, Noe, G., additional, Reid, S., additional, Roman, H., additional, Rousset, P., additional, Seyer Hansen, M., additional, Singh, S., additional, Thomas, V., additional, Timmerman, D., additional, Ulrich, U.A., additional, Van den Bosch, T., additional, Van Schoubroeck, D., additional, and Wattiez, A., additional
- Published
- 2024
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- View/download PDF
3. Non‐invasive imaging techniques for diagnosis of pelvic deep endometriosis and endometriosis classification systems: an International Consensus Statement.
- Author
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Condous, G., Gerges, B., Thomassin‐Naggara, I., Becker, C., Tomassetti, C., Krentel, H., van Herendael, B. J., Malzoni, M., Abrao, M. S., Saridogan, E., Keckstein, J., Hudelist, G., Aas‐Eng, K., Alcazar, J. L., Bafort, C., Bazot, M., Bielen, D., Bokor, A., Bourne, T., and Carmona, F.
- Subjects
PELVIC pain ,ENDOMETRIOSIS ,HUMAN reproduction ,HUMAN embryology ,DIAGNOSIS ,MEDICAL needs assessment - Abstract
The International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) and International Deep Endometriosis Analysis (IDEA) group, the European Endometriosis League (EEL), the European Society for Gynaecological Endoscopy (ESGE), the European Society of Human Reproduction and Embryology (ESHRE), the International Society for Gynecologic Endoscopy (ISGE), the American Association of Gynecologic Laparoscopists (AAGL) and the European Society of Urogenital Radiology (ESUR) elected an international, multidisciplinary panel of gynecological surgeons, sonographers and radiologists, including a steering committee, which searched the literature for relevant articles in order to review the literature and provide evidence‐based and clinically relevant statements on the use of imaging techniques for non‐invasive diagnosis and classification of pelvic deep endometriosis. Preliminary statements were drafted based on review of the relevant literature. Following two rounds of revisions and voting orchestrated by chairs of the participating societies, consensus statements were finalized. A final version of the document was then resubmitted to the society chairs for approval. Twenty statements were drafted, of which 14 reached strong and three moderate agreement after the first voting round. The remaining three statements were discussed by all members of the steering committee and society chairs and rephrased, followed by an additional round of voting. At the conclusion of the process, 14 statements had strong and five statements moderate agreement, with one statement left in equipoise. This consensus work aims to guide clinicians involved in treating women with suspected endometriosis during patient assessment, counseling and planning of surgical treatment strategies. © 2024 The Authors. Published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology, by Universa Press, by The International Society for Gynecologic Endoscopy, by Oxford University Press on behalf of European Society of Human Reproduction and Embryology, by Elsevier Inc. on behalf of American Association of Gynecologic Laparoscopists and by Elsevier B.V. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Pooled analysis of the surgical treatment for colorectal cancer liver metastases
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Veereman, G., Robays, J., Verleye, L., Leroy, R., Rolfo, C., Van Cutsem, E., Bielen, D., Ceelen, W., Danse, E., De Man, M., Demetter, P., Flamen, P., Hendlisz, A., Sinapi, I., Vanbeckevoort, D., Ysebaert, D., and Peeters, M.
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- 2015
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5. Ovarian torsion in a premenarcheal girl: MRI findings
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Van Kerkhove, F., Cannie, M., Op de beeck, K., Timmerman, D., Pienaar, A., Smet, M. H., Bielen, D., Vanbeckevoort, D., and Dymarkowski, S.
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- 2007
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6. Value of carbon dioxide wedged venography and transvenous liver biopsy in the definitive diagnosis of Abernethy malformation
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Collard, B., Maleux, G., Heye, S., Cool, M., Bielen, D., George, C., Roskams, T., and Van Steenbergen, W.
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- 2006
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7. Patient acceptance for CT colonography: what is the real issue?
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Thomeer, M., Bielen, D., Vanbeckevoort, D., Dymarkowski, S., Gevers, A., Rutgeerts, P., Hiele, M., Van Cutsem, E., and Marchal, G.
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- 2002
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8. IDEAL study: magnetic resonance imaging for suspected deep endometriosis assessment prior to laparoscopy is as reliable as radiological imaging as a complement to transvaginal ultrasonography
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Bielen, D., primary, Tomassetti, C., additional, Van Schoubroeck, D., additional, Vanbeckevoort, D., additional, De Wever, L., additional, Van den Bosch, T., additional, D'Hooghe, T., additional, Bourne, T., additional, D'Hoore, A., additional, Wolthuis, A., additional, Van Cleynenbreughel, B., additional, Meuleman, C., additional, and Timmerman, D., additional
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- 2020
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9. Implementation of patient-tailored contrast volumes based on body surface area and heart rate harmonizes contrast enhancement and reduces contrast load in small patients in portal venous phase abdominal CT
- Author
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Walgraeve, M.-S., primary, Pyfferoen, L., additional, Van De Moortele, K., additional, Zanca, F., additional, Bielen, D., additional, and Casselman, J.W., additional
- Published
- 2019
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10. The IDEAL study: MRI for suspected deep endometriosis assessment prior to laparoscopy is equally reliable as radiological imaging as a complement to transvaginal ultrasonography
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Bielen, D, Tomassetti, C, Van Schoubroeck, D, Vanbeckevoort, D, De Wever, L, Vanden Bosch, T, D'Hooghe, T, Bourne, T, D'hoore, A, Wolthuis, A, Van Cleynenbreughel, B, Meuleman, C, and Timmerman, D
- Subjects
Technology ,Deep endometriosis (DE) ,magnetic resonance imaging (MRI) ,SLIDING SIGN ,ACCURACY ,deep endometriosis ,laparoscopy ,intravenous urography (IVU) ,TVS ,double contrast barium enema ,double contrast barium enema (DCBE) ,transvaginal ultrasonography (TV-US) ,intravenous urography ,DIAGNOSTIC-VALUE ,RECTOSIGMOID ENDOMETRIOSIS ,INFILTRATING ENDOMETRIOSIS ,MRI FINDINGS ,CLINICAL EXAMINATION ,Obstetrics & Reproductive Medicine ,RECTAL-CANCER ,Science & Technology ,Radiology, Nuclear Medicine & Medical Imaging ,Obstetrics & Gynecology ,Acoustics ,tertiary care centers ,EUROPEAN-SOCIETY ,PELVIC ENDOMETRIOSIS ,1114 Paediatrics and Reproductive Medicine ,bowel endometriosis ,Life Sciences & Biomedicine ,MRI - Abstract
OBJECTIVES: this prospective observational study compared the value of magnetic resonance imaging (MRI) complementary to transvaginal ultrasonography (TV-US) to our standard preoperative assessment of patients with endometriosis referred for surgery in a tertiary care academic center. Based on the extent to which endometriosis affects reproductive organs, bowel, ureters, bladder or other abdominal organs, the surgery will be carried out by gynecologists only or by a multidisciplinary team involving abdominal surgeons and/or urologists. METHODS: In 74 women with clinically suspected deep endometriosis (DE) the standard preoperative imaging, i.e. an expert transvaginal ultrasonography (TV-US), complemented by an intravenous urography (IVU) for the evaluation of the ureters, and a double contrast barium enema (DCBE) for the evaluation of the rectum, sigmoid and caecum was compared with an expert TV-US complemented by a 'one-stop' abdominal and pelvic magnetic resonance imaging (MRI). The findings of the laparoscopy were the reference standard to provide an answer to the question if a 'one-stop' abdominal/pelvic MRI is equally reliable as our standard radiological imaging as a complement to transvaginal ultrasonography for preoperative triaging of patients with suspected urological and intestinal involvement by DE in tertiary care centers. RESULTS: The standard preoperative imaging as well as the combined findings of the TV-US and the MRI allowed a correct stratification for a monodisciplinary approach by gynecologists or a multidisciplinary approach in 90.5% of the patients. Both TV-US and DCBE underestimated the severity of the rectal involvement in 2.7%, whereas TV-US and/or DCBE overestimated it in 6.8% of the patients. CONCLUSIONS: In conclusion, complementary to an expert transvaginal ultrasound (TV-US) a 'one-stop' magnetic resonance imaging (MRI) predicts the intra-operative findings equally well as the standard radiological imaging (IVU and DCBE) in patients referred for endometriosis surgery in a tertiary care academic center.
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- 2019
11. Delivery related rupture of the gravid uterus: imaging findings: a case report
- Author
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Catry, F., Geusens, E., Vanbeckevoort, D., Volders, W., Bielen, D., and Spitz, B.
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- 2004
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12. Book Review
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Bielen, D.
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- 2001
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13. Radiologische beeldvorming van slikstoornissen bij volwassenen
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null VANBECKEVOORT D, null BIELEN D, null PONETTE E, null NIJS E, null HENDRICKX S, null DE WEVER L, null DYMARKOWSKI S, and null DEJAEGER E
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General Medicine - Published
- 2005
14. Intestinale obstructie: rol van radiologische beeldvorming
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null VANBECKEVOORT D, null BIELEN D, null NIJS E, null DYMARKOWSKI S, null PONETTE E, and null OP DE BEECK B
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General Medicine - Published
- 2003
15. Intraductale papillaire mucineuze tumor: een niet te miskennen vorm van pancreaslijden
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null VANBIERVLIET P, null ROELANDT P, null VERSLYPE C, null ECTORS N, null VAN BECKEVOORT D, null BIELEN D, null AERTS R, and null VAN STEENBERGEN W
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General Medicine - Published
- 2003
16. Auto-immune pancreatitis: een klinische entiteit
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null LAPAUW S, null DE VOLDER I, null ECTORS N, null VAN BECKEVOORT D, null BIELEN D, null AERTS R, null TOPAL B, null YAP SH, and null VAN STEENBERGEN W
- Subjects
General Medicine - Published
- 2002
17. Pooled analysis of the surgical treatment for colorectal cancer liver metastases.
- Author
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UCL - SSS/IREC/IMAG - Pôle d'imagerie médicale, UCL - (SLuc) Service de radiologie, Veereman, G, Robays, J, Verleye, L, Leroy, R, Rolfo, C, Van Cutsem, E, Bielen, D, Ceelen, W, Danse, Etienne, De Man, M, Demetter, P, Flamen, P, Hendlisz, A, Sinapi, I, Vanbeckevoort, D, Ysebaert, D, Peeters, M, UCL - SSS/IREC/IMAG - Pôle d'imagerie médicale, UCL - (SLuc) Service de radiologie, Veereman, G, Robays, J, Verleye, L, Leroy, R, Rolfo, C, Van Cutsem, E, Bielen, D, Ceelen, W, Danse, Etienne, De Man, M, Demetter, P, Flamen, P, Hendlisz, A, Sinapi, I, Vanbeckevoort, D, Ysebaert, D, and Peeters, M
- Abstract
Liver metastases in colorectal cancer patients decreases the expected 5 year survival rates by a factor close to nine. It is generally accepted that resection of liver metastases should be attempted whenever feasible. This manuscript addresses the optimal therapeutic plan regarding timing of resection of synchronous liver metastases and the use of chemotherapy in combination with resection of synchronous metachronous liver metastases. The aim is to pool all published results in order to attribute a level of evidence to outcomes and identify lacking evidence areas. A systematic search of guidelines, reviews, randomised controlled, observational studies and updating a meta-analysis was performed. Data were extracted and analysed. Data failed to demonstrate an effect of timing of surgery or use of chemotherapy on overall survival. Concomitant resection of liver metastases and the primary tumour may result in lower postoperative morbidity. Systemic peri-operative chemotherapy may improve progression free survival compared to surgery alone.
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- 2015
18. Virtual colonoscopy: a new screening tool for colorectal cancer?
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Thomeer, M., Vanbeckevoort, D., Bielen, D., Ludo Beenen, Gevers, A., Rutgeerts, P., Marchal, G., and Other departments
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One of the new forays into the field of medical imaging is the 3-D computer imaging. Thanks to new and more performant computer processing and 3-D rendering methods it is nowadays possible to generate high resolution images of the inner surface of the colon based on CT and MR images. This article reviews the current status and research directions of virtual colonoscopy and its possible eligibility of becoming a new tool for colorectal screening
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- 2001
19. Diagnostic accuracy of computed tomographic colonography for the detection of advanced neoplasia in individuals at increased risk of colorectal cancer
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Regge, D, Laudi, C, Galatola, G, Della Monica, P, Bonelli, L, Angelelli, G, Asnaghi, R, Barbaro, Brunella, Bartolozzi, C, Bielen, D, Boni, L, Borghi, Claudio, Bruzzi, P, Cassinis, Mc, Galia, M, Gallo, Tm, Grasso, Alessandra, Hassan, Cesare, Laghi, A, Martina, Mc, Neri, Elisabetta, Senore, C, Simonetti, G, Venturini, S, Gandini, Gustavo, Barbaro, Brunella (ORCID:0000-0002-9638-543X), Regge, D, Laudi, C, Galatola, G, Della Monica, P, Bonelli, L, Angelelli, G, Asnaghi, R, Barbaro, Brunella, Bartolozzi, C, Bielen, D, Boni, L, Borghi, Claudio, Bruzzi, P, Cassinis, Mc, Galia, M, Gallo, Tm, Grasso, Alessandra, Hassan, Cesare, Laghi, A, Martina, Mc, Neri, Elisabetta, Senore, C, Simonetti, G, Venturini, S, Gandini, Gustavo, and Barbaro, Brunella (ORCID:0000-0002-9638-543X)
- Abstract
Computed tomographic (CT) colonography has been recognized as an alternative for colorectal cancer (CRC) screening in average-risk individuals, but less information is available on its performance in individuals at increased risk of CRC.
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- 2009
20. Indicaties voor abdominale radiologische onderzoeken
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null VANBECKEVOORT D, null OP DE BEECK K, null DYMARKOWSKI S, null VANSLEMBROUCK R, null NIJS E, null THIJS M, and null BIELEN D
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General Medicine - Published
- 2006
21. Sonographic evaluation of transjugular intrahepatic porto-systemic shunt
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Holsbeeck, A Van, primary, Thijs, M, additional, Bielen, D, additional, Heye, S, additional, and Maleux, G, additional
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- 2013
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22. Yield of Routine Imaging after Curative Colorectal Cancer Treatment
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Jochmans, I., primary, Topal, B., additional, D’Hoore, A., additional, Aerts, R., additional, Vanbeckevoort, D., additional, Bielen, D., additional, Haustermans, K., additional, Van Cutsem, E., additional, and Penninckx, F., additional
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- 2008
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23. Ovarian torsion in a premenarcheal girl: MRI findings
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Van Kerkhove, F., primary, Cannie, M., additional, Op de beeck, K., additional, Timmerman, D., additional, Pienaar, A., additional, Smet, M. H., additional, Bielen, D., additional, Vanbeckevoort, D., additional, and Dymarkowski, S., additional
- Published
- 2006
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24. Delivery related rupture of the gravid uterus: imaging findings: a case report
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Catry, F., primary, Geusens, E., additional, Vanbeckevoort, D., additional, Volders, W., additional, Bielen, D., additional, and Spitz, B., additional
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- 2003
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25. Relevance of detecting additional small HCC lesions prior to liver transplantation
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Verslype, C., primary, Libbrecht, L., additional, Nevens, F., additional, Bielen, D., additional, Vanbeckevoort, D., additional, Fevery, J., additional, Pirenne, J., additional, and Roskams, T., additional
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- 2003
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26. Diffusion-weighted MRI provides additional value to conventional dynamic contrast-enhanced MRI for detection of hepatocellular carcinoma.
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Vandecaveye V, De Keyzer F, Verslype C, Op de Beeck K, Komuta M, Topal B, Roebben I, Bielen D, Roskams T, Nevens F, Dymarkowski S, Vandecaveye, Vincent, De Keyzer, Frederik, Verslype, Chris, Op de Beeck, Katya, Komuta, Mina, Topal, Baki, Roebben, Ilse, Bielen, Didier, and Roskams, Tania
- Abstract
The purpose of this study was to evaluate the accuracy of diffusion-weighted magnetic resonance imaging (DW-MRI) in differentiating HCC from benign cirrhotic lesions compared with conventional dynamic contrast-enhanced MRI. Fifty-five patients with cirrhosis underwent conventional and DW-MRI at 1.5 Tesla. Signal intensity ratios (SI(ratio)) of solid liver lesions to adjacent hepatic parenchyma were measured for b0, b100, b600 and b1000, and the apparent diffusion coefficients (ADC) were calculated. In 27 patients, imaging results were compared to histopathology, and in 28 patients, to imaging follow-up. Based on predetermined thresholds, sensitivity and specificity of DW-MRI and conventional MRI were compared. SI(ratio) was significantly different between malignant and benign lesions at all b-values (P < 0.0001). No significant difference in ADC was seen (P = 0.47). For detection of malignant lesions, DW-MRI with b600-SI(ratio) yielded a sensitivity of 95.2% compared to 80.6% for conventional MRI (P = 0.023) and a specificity of 82.7% compared to 65.4% (P = 0.064). The improved accuracy was most beneficial for differentiating malignant lesions smaller than 2 cm. DW-MRI with b600-SI(ratio) improved the detection of small HCC and the differentiation of pseudotumoral lesions compared with conventional MRI. [ABSTRACT FROM AUTHOR]
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- 2009
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27. A solitary hepatic lesion: MRI-pathological correlation of an hepatic angiomyolipoma (2004:4b).
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de Bruecker, Y., Ballaux, F., Allewaert, S., Vanbeckevoort, D., Bielen, D., Roskams, T., Aerts, R., Roex, L., and Simoens, M.
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MAGNETIC resonance imaging ,ABDOMINAL tumors ,SMOOTH muscle ,CYSTS (Pathology) ,ONCOLOGY ,CELLS - Abstract
The article reports that liver angiomyolipomas are very rare benign mesenchymal tumours. The histological appearance of the three components (blood vessels, smooth muscle cells and fat) is found the same as in the frequently encountered renal AML. Most cases are incidental findings. Less than 50% of the patients complain of vague epigastric pain. The radiological appearance of hepatic AML varies widely due to the fact that the distribution and the relative proportion of the three components varies widely from tumour to tumour. A well-circumscribed, hyperintense lesion on T1- and T2-weighted images is the most common imaging finding. The hypervascular pattern, the presence of central vessels (macro-aneurysms) and the absence of a capsule are other characteristic imaging features.
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- 2004
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28. Quality of life changes after inguinal hernia repair using anterior rectus sheath - A preliminary study
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Horžić, M., Mario Kopljar, Ćupurdija, K., Skupnjak, M., Korica, J., Lacković, Ž, Vanjak-Bielen, D., and Patrlj, L.
- Abstract
Chronic pain is the most serious long-term complication after groin hernia repair. The aim of this preliminary research was to assess the quality of life before and after standard tension-free mesh repair and new method of tension-free inguinal hernia repair using anterior rectus sheath. Total of 62 patients were evaluated. Anterior rectus sheath method was performed in 29 patients and in 33 patients standard mesh repair was used (Lichtenstein repair). Quality of life was assessed before and after the surgery using short-form SF-36 questionnaire (QualityMetric Inc.), adjusted for Croatian language. There were statistically significant improvements in bodily pain and general health scores in both groups. Patients operated using mesh technique also demonstrated statistically significant improvements in social functioning and emotional role. Similarly, patients in whom inguinal hernia was repaired using anterior rectus sheath had significantly better postoperative scores for physical functioning and role physical scores. Quality of life assessment demonstrated good ability to differentiate between several independent aspects of quality of life. Anterior rectus sheath repair significantly improved quality of life and was shown to be similar to mesh repair in the aspect of physical functioning.
29. Intrathoracic neurofibroma of the vagal nerve in a patient with von Recklinghausen's disease
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Bielen, D., primary, Verschakelen, J., additional, Wilms, G., additional, and Baert, A., additional
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- 1988
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30. A phase I radiation dose-escalation study to determine the maximal dose of radiotherapy in combination with weekly gemcitabine in patients with locally advanced pancreatic adenocarcinoma
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Aerts Raymond, Topal Baki, Van Steenbergen Werner, Van Cutsem Eric, Haustermans Karin, Budiharto Tom, Ectors Nadine, Bielen Didier, Vanbeckevoort Dirk, Goethals Laurence, and Verslype Chris
- Subjects
Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background The primary objective of this study was to determine the maximum tolerated dose (MTD) of escalating doses of radiotherapy (RT) concomitantly with a fixed dose of gemcitabine (300 mg/m2/week) within the same overall treatment time. Methods Thirteen patients were included. Gemcitabine 300 mg/m2/week was administered prior to RT. The initial dose of RT was 45 Gy in 1.8 Gy fractions, escalated by adding 5 fractions of 1.8 Gy (one/week) to a dose of 54 Gy with a total duration kept at 5 weeks. All patients received a dynamic MRI to assess the pancreatic respiratory related movements. Toxicity was scored using the RTOG-EORTC toxicity criteria. Results Three of six patients experienced an acute dose limiting toxicity (DLT) at the 54 Gy dose level. For these patients a grade III gastro-intestinal toxicity (GI) was noted. Patients treated at the 45 Gy dose level tolerated therapy without DLT. The 54 Gy dose level was designated as the MTD and was deemed not suitable for further investigation. Between both dose levels, there was a significant difference in percentage weight loss (p = 0.006) and also in cumulative GI toxicity (p = 0.027). There was no grade 3 toxicity in the 45 Gy cohort versus 4 grade 3 toxicity events in the 54 Gy cohort. The mean dose to the duodenum was significantly higher in the 54 Gy cohort (38.45 Gy vs. 51.82 Gy; p = 0.001). Conclusion Accelerated dose escalation to a total dose of 54 Gy with 300 mg/m2/week gemcitabine was not feasible. GI toxicity was the DLT. Retrospectively, the dose escalation of 9 Gy by accelerated radiotherapy might have been to large. A dose of 45 Gy is recommended. Considering the good patient outcomes, there might be a role for the investigation of a fixed dose of gemcitabine and concurrent RT with small fractions (1.8 Gy/day) in borderline resectable or unresectable non-metastatic locally advanced pancreatic cancer.
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- 2008
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31. A phase I radiation dose-escalation study to determine the maximal dose of radiotherapy in combination with weekly gemcitabine in patients with locally advanced pancreatic adenocarcinoma.
- Author
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Budiharto T, Haustermans K, Van Cutsem E, Van Steenbergen W, Topal B, Aerts R, Ectors N, Bielen D, Vanbeckevoort D, Goethals L, and Verslype C
- Abstract
Background: The primary objective of this study was to determine the maximum tolerated dose (MTD) of escalating doses of radiotherapy (RT) concomitantly with a fixed dose of gemcitabine (300 mg/m²/week) within the same overall treatment time. Methods: Thirteen patients were included. Gemcitabine 300 mg/m²/week was administered prior to RT. The initial dose of RT was 45 Gy in 1.8 Gy fractions, escalated by adding 5 fractions of 1.8 Gy (one/week) to a dose of 54 Gy with a total duration kept at 5 weeks. All patients received a dynamic MRI to assess the pancreatic respiratory related movements. Toxicity was scored using the RTOG-EORTC toxicity criteria. Results: Three of six patients experienced an acute dose limiting toxicity (DLT) at the 54 Gy dose level. For these patients a grade III gastro-intestinal toxicity (GI) was noted. Patients treated at the 45 Gy dose level tolerated therapy without DLT. The 54 Gy dose level was designated as the MTD and was deemed not suitable for further investigation. Between both dose levels, there was a significant difference in percentage weight loss (p = 0.006) and also in cumulative GI toxicity (p = 0.027). There was no grade 3 toxicity in the 45 Gy cohort versus 4 grade 3 toxicity events in the 54 Gy cohort. The mean dose to the duodenum was significantly higher in the 54 Gy cohort (38.45 Gy vs. 51.82 Gy; p = 0.001). Conclusion: Accelerated dose escalation to a total dose of 54 Gy with 300 mg/m²/week gemcitabine was not feasible. GI toxicity was the DLT. Retrospectively, the dose escalation of 9 Gy by accelerated radiotherapy might have been to large. A dose of 45 Gy is recommended. Considering the good patient outcomes, there might be a role for the investigation of a fixed dose of gemcitabine and concurrent RT with small fractions (1.8 Gy/day) in borderline resectable or unresectable non-metastatic locally advanced pancreatic cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2008
- Full Text
- View/download PDF
32. MRI imaging of the effects of infliximab in perianal fistulizing Crohn's disease
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Van Assche, G., Vanbeckevoort, D., Bielen, D., Coremans, G., Aerden, I., Noman, M., Vermeire, S., Marchal, G., Cornillie, F., and Rutgeerts, P.
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- 2001
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33. Not all black colons on [ 18 F]FDG PET are due to metformin.
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Boeckxstaens L, Vergote V, Dierickx D, Tousseyn T, Bielen D, Van Laere K, Deroose CM, and Goffin K
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- Humans, Fluorodeoxyglucose F18, Positron-Emission Tomography, Radiopharmaceuticals, Metformin
- Published
- 2023
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34. Endometriotic lung cyst causing catamenial hemoptysis; a case report and review of literature.
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Verhulst E, Bafort C, Tomassetti C, Wolthuis A, Bielen D, Coolen J, Weynand B, Platteeuw L, Meuleman C, and Van Raemdonck D
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- Female, Humans, Hemoptysis diagnosis, Hemoptysis etiology, Hemoptysis surgery, Menstruation, Lung, Endometriosis complications, Endometriosis diagnosis, Endometriosis surgery, Cysts complications, Cysts diagnosis, Cysts surgery
- Abstract
We report a rare case of an endometriotic lung cyst in a 47-year woman with recurrent catamenial hemoptysis. Chest computed tomography (CT) obtained outside the menstruation in October 2019 revealed a cystic lesion (2.5 cm) located in the right inferior lobe near the distal esophagus and the inferior pulmonary vein. Compared to CT abdomen in May 2019, this lesion had increased with a larger volume and a thicker wall. An endometrial lung cyst was suspected as episodes of hemoptysis no longer occurred after initiating hormonal treatment with nomegestrol acetate. Exploratory video-assisted thoracoscopic surgery with wedge resection of the cyst was performed. Histopathologic examination confirmed the diagnosis of an endometriotic cystic lesion. Postoperative course was uneventful with no further symptoms since then.
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- 2022
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35. [A spontaneous ilio-psoas hematoma].
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Bruynseraede R, Verelst S, Robben E, and Bielen D
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- Aged, Anticoagulants therapeutic use, Female, Humans, Pain, Retroperitoneal Space diagnostic imaging, Hematoma diagnostic imaging, Hematoma etiology, Psoas Muscles diagnostic imaging
- Abstract
Background: An ilio-psoas hematoma is a spontaneous or traumatic retroperitoneal hemorrhage in the ilio-psoas muscle. It is an uncommon condition, occurring in patients with bleeding disorders or patients on anticoagulant therapy. It has a high mortality and presents itself with non-specific symptoms like pain in de lower back, hip or upper leg., Case Description: We present the case of a 70-year-old women, on anticoagulant therapy, presenting with atraumatic pain in de left hip. On clinical exam she complained of pain with active hip flexion and passive hip extension. On CT angiography an iliac hematoma was visible on the left side with an arterial component. She underwent an urgent pelvic arterial embolization., Conclusion: Timely recognition and treatment of an iliopsoas hematoma can reduce mortality and morbidity. In elderly patients on anticoagulant therapy or with underlying bleeding disorders, this entity should always be considered in unexplained lumbar or hip pain.
- Published
- 2022
36. Doppler ultrasound to assess the pharmacodynamic effects of splanchnic vasoactive compounds.
- Author
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Marynissen H, Lodeweyckx T, Bielen D, and de Hoon J
- Subjects
- Blood Flow Velocity, Humans, Male, Reference Values, Reproducibility of Results, Ultrasonography, Ultrasonography, Doppler methods
- Abstract
Aims: In search of noninvasive biomarkers to assess the pharmacodynamic effects of portal pressure-lowering drugs, the reproducibility of flow measurements in the superior mesenteric artery was evaluated using Doppler ultrasound., Methods: A reproducibility study was conducted in 15 healthy male volunteers (18-50 y). Eight ultrasound measurements were performed for each subject: 2 observers each conducted 2 measurements during 2 separate visits. The following flow parameters were captured: peak systolic velocity (PSV), end diastolic velocity (EDV), pulsatility index (PI), volume flow (VF) and vessel diameter. Reproducibility was assessed by the intraclass correlation coefficient., Results: Results are presented as intraclass correlation coefficient [95% confidence interval]. The flow parameters PSV, EDV, PI and VF correlated excellently within observer during visit 1 (0.888 [0.748-0.953], 0.910 [0.793-0.962], 0.844 [0.656-0.933] and 0.916 [0.857-0.951], respectively) and visit 2 (0.925 [0.829-0.968], 0.942 [0.863-0.976], 0.883 [0.719-0.954] and 0.915 [0.855-0.951], respectively). Measurements conducted during 2 separate visits by 1 observer correlated well to excellently for PSV, EDV, PI and VF (0.756 [0.552-0.875], 0.836 [0.694-0.916], 0.807 [0.631-0.904] and 0.839 [0.783-0.882], respectively). Measurements conducted by 2 distinct observers correlated well to excellently for PSV, EDV and VF during visit 1 (0.813 [0.584-0.922], 0.884 [0.597-0.945] and 0.786 [0.575-0.899], respectively) and visit 2 (0.779 [0.498-0.912], 0.861 [0.672-0.945], 0.810 [0.553-0.926], respectively). Vessel diameter measurements were poorly reproducible., Conclusion: Doppler ultrasound is a reproducible method for flow measurements in the superior mesenteric artery in a standardized group of healthy volunteers. Therefore, it is a promising technique to assess pharmacodynamic effects of splanchnic vasoactive compounds in early clinical drug development., (© 2021 British Pharmacological Society.)
- Published
- 2022
- Full Text
- View/download PDF
37. Systematic review and meta-analysis of local resection or transanal endoscopic microsurgery versus radical resection in stage i rectal cancer: A real standard?
- Author
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Veereman G, Vlayen J, Robays J, Fairon N, Stordeur S, Rolfo C, Bielen D, Bols A, Demetter P, D'hoore A, Haustermans K, Hendlisz A, Lemmers A, Leonard D, Penninckx F, Van Cutsem E, and Peeters M
- Subjects
- Humans, Neoplasm Recurrence, Local pathology, Neoplasm Staging, Rectal Neoplasms pathology, Treatment Outcome, Neoplasm Recurrence, Local surgery, Rectal Neoplasms surgery, Transanal Endoscopic Microsurgery methods
- Abstract
Current guidelines recommend radical resection for stage I rectal cancer. However, since screening programs are being installed, an increasing number of cancers are being detected in early stages. Endoscopic resection is often performed at the time of diagnosis. This systematic review was undertaken to review the evidence on endoscopic approach vs. radical resection for stage I rectal cancer. Recommendations were issued based on the GRADE methodology and risk stratification used in clinical practice. A systematic search (until March 2015) identified 2 meta-analyses and 1 additional randomized trial. For the primary outcomes (overall survival, disease-free survival, local recurrence-free survival and metastasis-free survival) no evidence could be found on the superiority of local or radical resection. Secondary outcomes (blood loss, hospital stay, operative time, number of permanent stomas and perioperative deaths) were in favour of local resection. The authors strongly recommend radical resection for T2 rectal cancer, but consider 'en bloc' local resection sufficient for pT1 sm1 rectal cancers when confirmed pathologically. Discussion by a multidisciplinary team and adequate surveillance remain mandatory., (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Published
- 2017
- Full Text
- View/download PDF
38. Magnetic resonance imaging of perianal fistulas.
- Author
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Vanbeckevoort D, Bielen D, Vanslembrouck R, and Van Assche G
- Subjects
- Enteritis prevention & control, Humans, Preoperative Care methods, Rectal Fistula surgery, Anal Canal pathology, Enteritis complications, Enteritis pathology, Image Enhancement methods, Magnetic Resonance Imaging methods, Rectal Fistula etiology, Rectal Fistula pathology
- Abstract
Perianal fistulization is the result of a chronic inflammation of the perianal tissues. A wide spectrum of clinical manifestations, ranging from simple to complex fistulas, can be seen, the latter especially in patients with Crohn disease. Failure to detect secondary tracks and hidden abscesses may lead to therapeutic failure, such as insufficient response to medical treatment and relapse after surgery. Currently, magnetic resonance (MR) imaging is the preferred technique for evaluating perianal fistulas and associated complications. Initially used most often in the preoperative setting, MR imaging now also plays an important role in evaluating the response to medical therapy., (Copyright © 2014 Elsevier Inc. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
39. Sonographic evaluation of transjugular intrahepatic portosystemic shunt.
- Author
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Van Holsbeeck A, Thijs M, Bielen D, Heye S, and Maleux G
- Subjects
- Humans, Liver blood supply, Postoperative Complications diagnostic imaging, Ultrasonography, Liver diagnostic imaging, Portal Vein diagnostic imaging, Portasystemic Shunt, Transjugular Intrahepatic methods
- Abstract
The purpose of this article is to review the role of sonography before, during and after transjugular intrahepatic portosystemic shunt placement. A sonographic assessment of the liver and abdomen is recommended before the procedure. We illustrate several important sonographic findings for the echographist, which may alter the procedure approach or even preclude transjugular intrahepatic portosystemic shunt placement. The most challenging step during the procedure is the puncture of the right portal vein. Sonography can be a helpful tool in reducing the number of needle passes, thereby reducing the risk of hemorrhagic complications. Because of its non-invasive and cost-benefit nature, sonography is useful for transjugular intrahepatic portosystemic shunt follow-up. A baseline study at 24 to 48 hours is recommended to discover procedure-related complications. Long-term follow-up is important to detect malfunction of the shunt. Doppler ultrasound is very accurate in detecting shunt thrombosis. However, no consensus exists on the optimal sonographic screening protocol for detecting stenosis. We describe three sonographic parameters to detect transjugular intrahepatic portosystemic shunt stenosis with high sensitivity. Finally, additional sonographic parameters and potential pitfalls are provided in order to improve sensitivity.
- Published
- 2013
40. Histology obtained by needle biopsy gives additional information on the prognosis of hepatocellular carcinoma.
- Author
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van Malenstein H, Komuta M, Verslype C, Vandecaveye V, Van Calster B, Topal B, Laleman W, Cassiman D, Van Steenbergen W, Aerts R, Vanbeckevoort D, Bielen D, Pirenne J, van Pelt J, Roskams T, and Nevens F
- Abstract
Aim: Hepatocellular carcinomas (HCC) have a strong biological heterogeneity. Current prognostic scores do not include histology. Information on the behavior of HCC based on histology has been characterized on retrospective data and large tissue specimens. We aimed to assess the additional value of needle biopsy and keratin 19 (K19) assessment in a prospective manner., Methods: Between 2003 and 2008, all patients with a confirmed diagnosis of HCC by a percutaneous or laparoscopic needle biopsy at the time of diagnosis, and of Barcelona Clinic Liver Cancer (BCLC) stage A, B or C, were included. The exclusion criterion was a palliative setting. Biopsies were scored for microvascular invasion, differentiation, K19, epithelial cell adhesion molecule and α-fetoprotein staining. Clinical and radiological features were registered at time of biopsy. The added value of K19 was assessed using Cox proportional hazards regression., Results: Of 74 patients screened, we included 58 patients. Based on the BCLC, 41% presented with early disease (BCLC A), 16% with intermediate disease (BCLC B) and 43% with advanced disease (BCLC C). In nine patients (16%), K19 staining was positive. Median follow up was 54 months (range 1-74) and 43 patients (72%) died. BCLC classification predicted the prognosis accurately, but histology offered additional prognostic information. In multivariate analysis, K19 was a strong predictor of overall survival (hazard ratio 4.57, 95% confidence interval 1.86-10.6), which improved predictive performance. No needle tract dissemination was observed., Conclusion: Despite the possible problem of sampling error, needle biopsy offered additional prognostic information. This is especially the case for K19 staining., (© 2012 The Japan Society of Hepatology.)
- Published
- 2012
- Full Text
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41. Wandering spleen on a 68Ga-DOTATOC-PET/CT scan.
- Author
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Lips N, Deroose CM, Bielen D, Bossuyt P, and Mortelmans L
- Subjects
- Aged, Female, Humans, Wandering Spleen pathology, Wandering Spleen physiopathology, Octreotide analogs & derivatives, Organometallic Compounds, Positron-Emission Tomography, Tomography, X-Ray Computed, Wandering Spleen diagnostic imaging
- Published
- 2011
- Full Text
- View/download PDF
42. Long-term monitoring of infliximab therapy for perianal fistulizing Crohn's disease by using magnetic resonance imaging.
- Author
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Karmiris K, Bielen D, Vanbeckevoort D, Vermeire S, Coremans G, Rutgeerts P, and Van Assche G
- Subjects
- Adolescent, Adult, Cohort Studies, Crohn Disease complications, Crohn Disease pathology, Crohn Disease surgery, Follow-Up Studies, Humans, Infliximab, Rectal Fistula etiology, Rectal Fistula surgery, Treatment Outcome, Antibodies, Monoclonal therapeutic use, Crohn Disease drug therapy, Gastrointestinal Agents therapeutic use, Magnetic Resonance Imaging, Rectal Fistula drug therapy, Rectal Fistula pathology
- Abstract
Background & Aims: Magnetic resonance imaging (MRI) is used to assess the outcome of infliximab (IFX) therapy in patients with perianal fistulizing Crohn's disease (pfCD). However, few long-term data are available about its efficacy., Methods: We assessed 59 patients with pfCD by MRI and clinical evaluation at baseline. Treated patients then received paired clinical and MRI examinations for a median time period of 36 (11-53.3) weeks. Short-, mid-, and long-term effects of therapy, as well as the ability of MRI to predict treatment outcome and need for surgery, were evaluated., Results: Compared with the baseline MRI, the short-term follow-up MRI (n = 29) revealed a reduced number of fistula tracks in 13.8% and in the inflammatory activity in 55.2% of patients, respectively; mid-term MRI (n = 25) in 56% and in 52%, respectively; and long-term MRI (n = 13) in 15.4% and in 31%, respectively. Improvement of pfCD based on MRI results coincided with clinical improvement in 54.7% of the patients. Short-term and mid-term (but not long-term) MRI showed a significant decrease in the activity score. Therapy outcome was worse among patients with persisting fistulas (P = .01), collections (P = .009), and rectal wall involvement (P = .01) in the final MRI. Patients with single-branched fistulas (P < .0001) and collections (P = .006) in their baseline MRI were more likely to undergo surgery., Conclusions: MRI is a useful technique for evaluation of pfCD during the first year of follow-up. In the long-term, the MRI improvement coincides with clinical and endoscopic response to IFX in 50% of the patients., (Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.)
- Published
- 2011
- Full Text
- View/download PDF
43. Diagnostic accuracy of computed tomographic colonography for the detection of advanced neoplasia in individuals at increased risk of colorectal cancer.
- Author
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Regge D, Laudi C, Galatola G, Della Monica P, Bonelli L, Angelelli G, Asnaghi R, Barbaro B, Bartolozzi C, Bielen D, Boni L, Borghi C, Bruzzi P, Cassinis MC, Galia M, Gallo TM, Grasso A, Hassan C, Laghi A, Martina MC, Neri E, Senore C, Simonetti G, Venturini S, and Gandini G
- Subjects
- Adult, Aged, Colonoscopy, Colorectal Neoplasms diagnosis, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Risk Factors, Sensitivity and Specificity, Colonography, Computed Tomographic, Colorectal Neoplasms diagnostic imaging
- Abstract
Context: Computed tomographic (CT) colonography has been recognized as an alternative for colorectal cancer (CRC) screening in average-risk individuals, but less information is available on its performance in individuals at increased risk of CRC., Objective: To assess the accuracy of CT colonography in detecting advanced colorectal neoplasia in asymptomatic individuals at increased risk of CRC using unblinded colonoscopy as the reference standard., Design, Setting, and Participants: This was a multicenter, cross-sectional study. Individuals at increased risk of CRC due to either family history of advanced neoplasia in first-degree relatives, personal history of colorectal adenomas, or positive results from fecal occult blood tests (FOBTs) were recruited in 11 Italian centers and 1 Belgian center between December 2004 and May 2007. Each participant underwent CT colonography followed by colonoscopy on the same day., Main Outcome Measures: Sensitivity and specificity of CT colonography in detecting individuals with advanced neoplasia (ie, advanced adenoma or CRC) 6 mm or larger., Results: Of 1103 participants, 937 were included in the final analysis: 373 cases in the family-history group, 343 in the group with personal history of adenomas, and 221 in the FOBT-positive group. Overall, CT colonography identified 151 of 177 participants with advanced neoplasia 6 mm or larger (sensitivity, 85.3%; 95% confidence interval [CI], 79.0%-90.0%) and correctly classified results as negative for 667 of 760 participants without such lesions (specificity, 87.8%; 95% CI, 85.2%-90.0%). The positive and negative predictive values were 61.9% (95% CI, 55.4%-68.0%) and 96.3% (95% CI, 94.6%-97.5%), respectively; after group stratification, a significantly lower negative predictive value was found for the FOBT-positive group (84.9%; 95% CI, 76.2%-91.3%; P < .001)., Conclusions: In a group of persons at increased risk for CRC, CT colonography compared with colonoscopy resulted in a negative predictive value of 96.3% overall. When limited to FOBT-positive persons, the negative predictive value was 84.9%.
- Published
- 2009
- Full Text
- View/download PDF
44. Screening for colorectal cancer using ct colonography: facing the challenges.
- Author
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Bielen D
- Subjects
- Colonoscopy, Humans, Colonography, Computed Tomographic methods, Colorectal Neoplasms diagnostic imaging
- Published
- 2009
45. Computed tomographic colonography: automated tool for polyp measurement delivering on patient risk stratification.
- Author
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Bielen D, Vanslembrouck R, De Keyzer F, Vandenhout H, Guendel L, Van Cutsem E, and Marchal G
- Subjects
- Adult, Aged, Colonic Polyps diagnostic imaging, Feasibility Studies, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Observer Variation, Outpatients, Phantoms, Imaging, Reproducibility of Results, Risk Assessment methods, Severity of Illness Index, Software Validation, Colonic Polyps diagnosis, Colonography, Computed Tomographic methods, Software
- Abstract
Objective: We evaluated an automated polyp size measurement tool in computed tomographic colonography for its accuracy and value for patient risk stratification., Methods: A simulation program generated a raw data phantom with sessile and pedunculated polyps of known sizes using 120 to 140 kV and 50, 40, 20, 15, and 10 mAs. All polyps were measured by clicking on the polyp surface. Comparison of the calculated size with the known polyp sizes allowed calculation of reproducibility and accuracy. For patients with proven polyps, we also compared automated measurements with manual and endoscopic measurements to evaluate the effect on patient risk stratification., Results: The automated measurement tool allowed accurate measurements. In the patient study, assignment to the correct size group was not significantly different from the radiologist's results. However, it slightly improved patient risk stratification by reducing both failed and unnecessary colonoscopy referral., Conclusions: An automated tool for polyp measurement in patients facilitates patient risk stratification.
- Published
- 2008
- Full Text
- View/download PDF
46. Successful conservative treatment of endocervical adenocarcinoma stage Ib1 diagnosed early in pregnancy.
- Author
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Van Calsteren K, Hanssens M, Moerman P, Orye G, Bielen D, Vergote I, and Amant F
- Subjects
- Adenocarcinoma diagnosis, Adult, Cervix Uteri surgery, Female, Humans, Lymph Node Excision, Pregnancy, Pregnancy Complications, Neoplastic diagnosis, Pregnancy Trimester, First, Uterine Cervical Neoplasms diagnosis, Adenocarcinoma surgery, Early Diagnosis, Pregnancy Complications, Neoplastic surgery, Uterine Cervical Neoplasms surgery
- Abstract
Traditionally when cervical cancer is diagnosed during the first trimester of pregnancy, oncological treatment is given priority despite the pregnant state. A 32-year-old primigravida was diagnosed with invasive endocervical adenocarcinoma stage Ib1 at 8 weeks' gestation. As the patient wanted to preserve the pregnancy, an amputation of the anterior cervix and retroperitoneal pelvic lymphadenectomy were performed. Based on favourable prognostic markers, we decided to maintain the pregnancy with careful cytological and histological follow-up. The patient gave birth at term to a healthy boy, and 18 months after the delivery there is no evidence of recurrent disease. In the absence of poor prognostic markers, we decided to adopt a conservative approach for cervical adenocarcinoma in a pregnant patient at 8 weeks' gestation.
- Published
- 2008
- Full Text
- View/download PDF
47. Computer-aided detection for CT colonography: update 2007.
- Author
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Bielen D and Kiss G
- Subjects
- Automation, Colonic Polyps diagnosis, Colonography, Computed Tomographic trends, Diagnosis, Computer-Assisted trends, Humans, Imaging, Three-Dimensional methods, Models, Anatomic, Pattern Recognition, Automated, Radiographic Image Interpretation, Computer-Assisted, Reproducibility of Results, Sensitivity and Specificity, Colonic Neoplasms diagnosis, Colonography, Computed Tomographic methods, Diagnosis, Computer-Assisted methods
- Abstract
Computed tomographic colonography (CTC) is an emerging technique for polyp detection in the colon. However, lesion detection can be challenging due to insufficient patient preparation, chosen CT technique or reader imperfection. The primary goal of computer-aided detection (CAD) for CTC is locating possible polyps, and presenting the reader with these polyp candidates. Other goals are sensitivity improvement and reduction of reading time and inter-observer variability. The multistep CAD procedure typically consists of segmentation of the colonic wall (e.g. region growing); selection of intermediate polyp candidates (curvature analysis, sphere fitting, normal analysis, slope density function ...); classification of final candidates for detection and listing suspicious polyps (location, size and volume). Remaining task for the radiologist is the validation or rejection of the polyp candidates. State-of-the-art CAD systems should require minimal or even no user interaction for the extraction of the colonic wall, offer a computation time less than 10-20 min and high sensitivity and specificity for different polyp sizes and shapes, with a low number of false positives. These systems have the potential to increase radiologist's performance and to decrease inter-reader variability. Besides CAD key techniques we also discuss new developments in CAD and describe recent applications facilitating CTC.
- Published
- 2007
- Full Text
- View/download PDF
48. Anterior rectus sheath in inguinal hernia repair: preliminary study.
- Author
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Horzic M, Kopljar M, Cupurdija K, Lackovic Z, and Vanjak-Bielen D
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Postoperative Complications, Prospective Studies, Surgical Mesh adverse effects, Treatment Outcome, Hernia, Inguinal surgery, Rectus Abdominis surgery, Surgical Flaps adverse effects
- Abstract
Inguinal hernia repair using the anterior rectus sheath flap represents a tension-free repair with potential advantages (no foreign material or tension on the suture line). The aim of this research was to evaluate the method of inguinal hernia repair using the anterior rectus sheath and to compare it with tension-free mesh repair (modified Lichtenstein repair). In total, 62 patients were evaluated. Each patient's age, gender, type of hernia, total operating-room time, the length of postoperative hospital stay, and the recurrence-free period were recorded, as well as the total number of postoperatively administered doses of analgesics, and analyzed using the Mann-Whitney test. No difference in age (p = .08), postoperative hospital stay (p = 0.810), or postoperative use of analgesics (p = .116) was observed between two groups. Total operating-room time was significantly longer in patients undergoing mesh repair (median 80 min, range 45-150) compared to anterior rectus sheath repair (median 65 min, range 45-125) (p = .049). No complications or recurrences were noted in either group. Thus, this study showed good results using the anterior rectus sheath repair for primary, uncomplicated inguinal hernias, comparable to mesh repair.
- Published
- 2007
- Full Text
- View/download PDF
49. Computer-aided detection of colonic polyps using low-dose CT acquisitions.
- Author
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Kiss G, Drisis S, Bielen D, Maes F, Van Cleynenbreugel J, Marchal G, and Suetens P
- Subjects
- Humans, Information Storage and Retrieval methods, Radiation Dosage, Radiation Protection methods, Reproducibility of Results, Sensitivity and Specificity, Algorithms, Artificial Intelligence, Colonic Polyps diagnostic imaging, Pattern Recognition, Automated methods, Radiographic Image Enhancement methods, Radiographic Image Interpretation, Computer-Assisted methods, Tomography, X-Ray Computed methods
- Abstract
Rationale and Objectives: This report proposes an alternative method for the automatic detection of colonic polyps that is robust enough to be directly applicable on low-dose computed tomographic data., Materials and Methods: The polyp modeling process takes into account both the gray-level appearance of polyps (intensity profiles) and their geometry (extended Gaussian images). Spherical harmonic decompositions are used for comparison purposes, allowing fast estimation of the similarity between a candidate and a set of previously computed models. Starting from the original raw data (acquired at 55 mA), five patient data sets (prone and supine scans) are reconstructed at different dose levels (to 5 mA) by using different kernel filters, slice overlaps, and increments. Additionally, the efficacy of applying an edge-preserving smoothing filter before detection is assessed., Results: Although image quality decreases when decreasing acquisition milliamperes, all polyps greater than 6 mm are detected successfully, even at 15 mA. Although not important at high doses, smoothing improves detection results for ultra-low-dose (tube current<15 mA) data., Conclusion: The advantage of low-dose scans is a significant decrease in effective dose from 4.93 to 1.61 mSv while retaining high detection values, particularly important when thinking of population screening.
- Published
- 2006
- Full Text
- View/download PDF
50. Quality of life changes after inguinal hernia repair using anterior rectus sheath--a preliminary study.
- Author
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Horzić M, Kopljar M, Cupurdija K, Skupnjak M, Korica J, Lacković Z, Vanjak-Bielen D, and Patrlj L
- Subjects
- Chronic Disease, Female, Humans, Male, Middle Aged, Statistics, Nonparametric, Surgical Mesh, Hernia, Inguinal surgery, Pain, Postoperative prevention & control, Quality of Life, Rectus Abdominis transplantation, Surgical Flaps
- Abstract
Chronic pain is the most serious long-term complication after groin hernia repair. The aim of this preliminary research was to assess the quality of life before and after standard tension-free mesh repair and new method of tension-free inguinal hernia repair using anterior rectus sheath. Total of 62 patients were evaluated. Anterior rectus sheath method was performed in 29 patients and in 33 patients standard mesh repair was used (Lichtenstein repair). Quality of life was assessed before and after the surgery using short-form SF-36 questionnaire (QualityMetric Inc.), adjusted for Croatian language. There were statistically significant improvements in bodily pain and general health scores in both groups. Patients operated using mesh technique also demonstrated statistically significant improvements in social functioning and emotional role. Similarly, patients in whom inguinal hernia was repaired using anterior rectus sheath had significantly better postoperative scores for physical functioning and role physical scores. Quality of life assessment demonstrated good ability to differentiate between several independent aspects of quality of life. Anterior rectus sheath repair significantly improved quality of life and was shown to be similar to mesh repair in the aspect of physical functioning.
- Published
- 2006
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