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419 results on '"Biederer, J."'

1. Expiratory Venous Volume and Arterial Tortuosity are Associated with Disease Severity and Mortality Risk in Patients with COPD: Results from COSYCONET

Author

Stoleriu MG, Pienn M, Joerres RA, Alter P, Fero T, Urschler M, Kovacs G, Olschewski H, Kauczor HU, Wielpütz M, Jobst B, Welte T, Behr J, Trudzinski FC, Bals R, Watz H, Vogelmeier CF, Biederer J, and Kahnert K

Subjects
copd, computed tomography, pulmonary vasculature, vessel volume, vessel tortuosity, lung function, Diseases of the respiratory system, RC705-779
Abstract

Mircea Gabriel Stoleriu,1,2,&ast; Michael Pienn,3,4,&ast; Rudolf A Joerres,5 Peter Alter,6 Tamas Fero,7 Martin Urschler,8 Gabor Kovacs,3,9 Horst Olschewski,3,9 Hans-Ulrich Kauczor,7,10 Mark Wielpütz,7,10 Bertram Jobst,7,10 Tobias Welte,11 Jürgen Behr,2,12 Franziska C Trudzinski,10,13 Robert Bals,14,15 Henrik Watz,16 Claus F Vogelmeier,6 Jürgen Biederer,10,17,18,&ast; Kathrin Kahnert2,12,19,&ast; On behalf of the COSYCONET Study Group1Division for Thoracic Surgery Munich, Ludwig-Maximilians-University of Munich (LMU) and Asklepios Medical Center; Munich-Gauting, Gauting, 82131, Germany; 2Institute for Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive; Helmholtz Center Munich; Member of the German Lung Research Center (DZL), Munich, 81377, Germany; 3Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria; 4Division of Pulmonology, Department of Internal Medicine, Medical University of Graz, Graz, Austria; 5Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Hospital of Ludwig-Maximilians-University Munich (LMU), Munich, 80336, Germany; 6Department of Medicine, Pulmonary and Critical Care Medicine, University of Marburg (UMR), Member of the German Center for Lung Research (DZL), Marburg, 35033, Germany; 7Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany; 8Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria; 9University Clinic for Internal Medicine, Medical University of Graz, Division of Pulmonology, Graz, Austria; 10Translational Lung Research Center Heidelberg, Member of the German Center for Lung Research DZL, Heidelberg, Germany; 11Department of Respiratory Medicine and Infectious Disease, Member of the German Center of Lung Research, Hannover School of Medicine, Hannover, Germany; 12Department of Medicine V, LMU University Hospital, LMU Munich, Member of the German Center for Lung Research (DZL), Munich, Germany; 13Department of Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg, Heidelberg, Germany; 14Department of Internal Medicine V-Pulmonology, Allergology and Respiratory Critical Care Medicine, Saarland University, Homburg, 66421, Germany; 15Helmholtz Institute for Pharmaceutical Research, Saarbrücken, 66123, Germany; 16Pulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Centre North, German Centre for Lung Research, Großhansdorf, Germany; 17Faculty of Medicine, Christian-Albrechts-Universität Zu Kiel, Kiel, Germany; 18University of Latvia, Faculty of Medicine, Riga, LV-1586, Latvia; 19MediCenterGermering, Germering, Germany&ast;These authors contributed equally to this workCorrespondence: Mircea Gabriel Stoleriu, Division of Thoracic Surgery Munich, Ludwig-Maximilians-University of Munich (LMU) and Asklepios Lung Clinic Munich-Gauting, Marchioninistr. 15, 81377 Munich and Robert-Koch-Allee 2, Gauting, 82131, Germany, Tel +49 89 85791 4201, Email gabriel.stoleriu@helmholtz-munich.dePurpose: The aim of this study was to evaluate the association between computed tomography (CT) quantitative pulmonary vessel morphology and lung function, disease severity, and mortality risk in patients with chronic obstructive pulmonary disease (COPD).Patients and Methods: Participants of the prospective nationwide COSYCONET cohort study with paired inspiratory-expiratory CT were included. Fully automatic software, developed in-house, segmented arterial and venous pulmonary vessels and quantified volume and tortuosity on inspiratory and expiratory scans. The association between vessel volume normalised to lung volume and tortuosity versus lung function (forced expiratory volume in 1 sec [FEV1]), air trapping (residual volume to total lung capacity ratio [RV/TLC]), transfer factor for carbon monoxide (TLCO), disease severity in terms of Global Initiative for Chronic Obstructive Lung Disease (GOLD) group D, and mortality were analysed by linear, logistic or Cox proportional hazard regression.Results: Complete data were available from 138 patients (39% female, mean age 65 years). FEV1, RV/TLC and TLCO, all as % predicted, were significantly (p < 0.05 each) associated with expiratory vessel characteristics, predominantly venous volume and arterial tortuosity. Associations with inspiratory vessel characteristics were absent or negligible. The patterns were similar for relationships between GOLD D and mortality with vessel characteristics. Expiratory venous volume was an independent predictor of mortality, in addition to FEV1.Conclusion: By using automated software in patients with COPD, clinically relevant information on pulmonary vasculature can be extracted from expiratory CT scans (although not inspiratory scans); in particular, expiratory pulmonary venous volume predicted mortality.Trial Registration: NCT01245933.Keywords: COPD, computed tomography, pulmonary vasculature, vessel volume, vessel tortuosity, lung function

Published
2024

3. COVID-19 pneumonia imaging follow-up: when and how? A proposition from ESTI and ESR

Author

Martini, K, Larici, A R, Revel, M P, Ghaye, B, Sverzellati, N, Parkar, A P, Snoeckx, A, Screaton, N, Biederer, J, Prosch, H, Silva, M, Brady, A, Gleeson, F, Frauenfelder, T, European Society of Thoracic Imaging (ESTI), the European Society of Radiology (ESR), University of Zurich, European Society of Thoracic Imaging (ESTI), European Society of Radiology (ESR), UCL - SSS/IREC/IMAG - Pôle d'imagerie médicale, UCL - (SLuc) Centre du cancer, and UCL - (SLuc) Service de radiologie

Subjects
medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Acute infection, 610 Medicine & health, Multidetector computed tomography, Medical imaging, Medicine, Humans, Radiology, Nuclear Medicine and imaging, General Medicine / COVID, Tomography, Lung, Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA, Neuroradiology, Computer. Automation, medicine.diagnostic_test, business.industry, 10042 Clinic for Diagnostic and Interventional Radiology, Follow-up, COVID-19, Interventional radiology, General Medicine, Pneumonia, medicine.disease, X-Ray Computed, medicine.anatomical_structure, Radiology Nuclear Medicine and imaging, Chest, Diagnostic imaging, Organizing pneumonia, Radiology, Human medicine, business, Tomography, X-Ray Computed
Abstract

Abstract This document from the European Society of Thoracic Imaging (ESTI) and the European Society of Radiology (ESR) discusses the role of imaging in the long-term follow-up of COVID-19 patients, to define which patients may benefit from imaging, and what imaging modalities and protocols should be used. Insights into imaging features encountered on computed tomography (CT) scans and potential pitfalls are discussed and possible areas for future review and research are also included. Key Points • Post-COVID-19 pneumonia changes are mainly consistent with prior organizing pneumonia and are likely to disappear within 12 months of recovery from the acute infection in the majority of patients. • At present, with the longest series of follow-up examinations reported not exceeding 12 months, the development of persistent or progressive fibrosis in at least some individuals cannot yet be excluded. • Residual ground glass opacification may be associated with persisting bronchial dilatation and distortion, and might be termed “fibrotic-like changes” probably consistent with prior organizing pneumonia.

Published
2021

5. COVID-19 pneumonia imaging follow-up: when and how? A proposition from ESTI and ESR.

Author

UCL - SSS/IREC/IMAG - Pôle d'imagerie médicale, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de radiologie, Martini, K, Larici, A R, Revel, M P, Ghaye, B, Sverzellati, N, Parkar, A P, Snoeckx, A, Screaton, N, Biederer, J, Prosch, H, Silva, M, Brady, A, Gleeson, F, Frauenfelder, T, European Society of Thoracic Imaging (ESTI), the European Society of Radiology (ESR), UCL - SSS/IREC/IMAG - Pôle d'imagerie médicale, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de radiologie, Martini, K, Larici, A R, Revel, M P, Ghaye, B, Sverzellati, N, Parkar, A P, Snoeckx, A, Screaton, N, Biederer, J, Prosch, H, Silva, M, Brady, A, Gleeson, F, Frauenfelder, T, and European Society of Thoracic Imaging (ESTI), the European Society of Radiology (ESR)

Abstract

This document from the European Society of Thoracic Imaging (ESTI) and the European Society of Radiology (ESR) discusses the role of imaging in the long-term follow-up of COVID-19 patients, to define which patients may benefit from imaging, and what imaging modalities and protocols should be used. Insights into imaging features encountered on computed tomography (CT) scans and potential pitfalls are discussed and possible areas for future review and research are also included. KEY POINTS: • Post-COVID-19 pneumonia changes are mainly consistent with prior organizing pneumonia and are likely to disappear within 12 months of recovery from the acute infection in the majority of patients. • At present, with the longest series of follow-up examinations reported not exceeding 12 months, the development of persistent or progressive fibrosis in at least some individuals cannot yet be excluded. • Residual ground glass opacification may be associated with persisting bronchial dilatation and distortion, and might be termed "fibrotic-like changes" probably consistent with prior organizing pneumonia.

Published
2022

6. COVID-19 pneumonia imaging follow-up: when and how? A proposition from ESTI and ESR

Author

Martini, K; https://orcid.org/0000-0002-2638-6832, Larici, A R, Revel, M P, Ghaye, B, Sverzellati, N, Parkar, A P, Snoeckx, A, Screaton, N, Biederer, J, Prosch, H, Silva, M, Brady, A, Gleeson, F, Frauenfelder, T, Martini, K; https://orcid.org/0000-0002-2638-6832, Larici, A R, Revel, M P, Ghaye, B, Sverzellati, N, Parkar, A P, Snoeckx, A, Screaton, N, Biederer, J, Prosch, H, Silva, M, Brady, A, Gleeson, F, and Frauenfelder, T

Abstract

This document from the European Society of Thoracic Imaging (ESTI) and the European Society of Radiology (ESR) discusses the role of imaging in the long-term follow-up of COVID-19 patients, to define which patients may benefit from imaging, and what imaging modalities and protocols should be used. Insights into imaging features encountered on computed tomography (CT) scans and potential pitfalls are discussed and possible areas for future review and research are also included. KEY POINTS: • Post-COVID-19 pneumonia changes are mainly consistent with prior organizing pneumonia and are likely to disappear within 12 months of recovery from the acute infection in the majority of patients. • At present, with the longest series of follow-up examinations reported not exceeding 12 months, the development of persistent or progressive fibrosis in at least some individuals cannot yet be excluded. • Residual ground glass opacification may be associated with persisting bronchial dilatation and distortion, and might be termed "fibrotic-like changes" probably consistent with prior organizing pneumonia. Keywords: COVID-19; Diagnostic imaging; Follow-up; Lung; Multidetector computed tomography

Published
2022

40. Rolle der MRT zur Detektion und Abklärung pulmonaler Rundherde

Author

Sommer, G., Koenigkam-Santos, M., Biederer, J., Puderbach, M., Sommer, G., Koenigkam-Santos, M., Biederer, J., and Puderbach, M.

Abstract

Zusammenfassung: Hintergrund: Mit den technischen Weiterentwicklungen in den vergangenen Jahren hat sich die MRT zu einem methodisch ausgereiften und für spezifische pulmonale Fragestellungen bereits auch klinisch bewährten Untersuchungsverfahren entwickelt. Ohne Strahlenexposition kombiniert sie morphologische und funktionelle Diagnostik und ergänzt das Spektrum der etablierten Verfahren für die bildgebende Diagnostik der Lunge. Ziel der Arbeit und Methoden: Diese Arbeit gibt einen Überblick über die aktuell verwendeten Sequenzen und Techniken zur Darstellung pulmonaler Rundherde und analysiert deren klinischen Stellenwert anhand der aktuellen Studienlage. In Zentrum stehen dabei die Detektion pulmonaler Metastasen, die Detektion primär pulmonaler Malignome bei Personen mit Risikoprofil und die Abklärung pulmonaler Rundherde hinsichtlich ihrer Dignität. Ergebnisse und Diskussion: Die MRT besitzt im Vergleich zum Referenzstandard Niedrigdosis-CT eine Sensitivität von ca. 80 % für die Detektion maligner pulmonaler Rundherde und ist der CT damit etwas unterlegen. Vorteile der MRT gegenüber der Niedrigdosis-CT sind andererseits die höhere Spezifität bei der Differenzierung maligner und benigner pulmonaler Rundherde sowie die fehlende Strahlenexposition. Außerhalb von Studien kann ein breiter Einsatz der MRT als Screeningverfahren zur Detektion und Abklärung pulmonaler Rundherde aufgrund der noch ungenügenden Datenlage derzeit noch nicht empfohlen werden. Das diagnostische Potenzial der MRT für die Früherkennung und das Staging pulmonaler Malignome rechtfertigt aber die weitere Evaluation der MRT als sekundäre Modalität im Rahmen von Studien.

Published
2019

44. GOLD stage predicts thoracic aortic calcifications in patients with COPD

Author

Jobst, Bertram, primary, Owsijewitsch, Michael, additional, Kauczor, Hans‑Ulrich, additional, Biederer, J�rgen, additional, Ley, Sebastian, additional, Becker, Nikolaus, additional, Kopp‑Schneider, Annette, additional, Delorme, Stefan, additional, Heussel, Claus, additional, Puderbach, Michael, additional, Wielp�tz, Mark, additional, and Ley‑Zaporozhan, Julia, additional

Published
2018
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50. Semi-automated volumetric analysis of lymph node metastases during follow-up - Initial results

Author

Fabel, M., Bolte, H., Tengg-Kobligk, H. von, Bornemann, L., Dicken, V., Delorme, S., Kauczor, H.-U., Heller, M., Biederer, J., and Publica

Abstract

Objective: Quantification of tumour burden in oncology requires accurate and reproducible evaluation. The current standard is RECIST measurement with its inherent disadvantages. Volumetric analysis is an alternative for therapy monitoring. The aim of this study was to evaluate the feasibility of volumetric analysis of lymph node metastases using a software prototype in a follow-up setting. Methods: MSCT was performed in 50 patients covering the chest, abdomen and pelvis. A total of 174 suspicious lymph nodes were evaluated by two radiologists regarding short axis diameters and volumetric analysis using semi-automated software. Quality of segmentation, time, maximum diameter and volume were documented. Variability of the derived change rates was computed as the standard deviation of the difference of the obtained respective change rates. Results: The software performance provides robust volumetric analysis. Quality of segmentation was rated acceptable to excellent in 76- 79% by each reader. Mean time spent per lesion was 38 s. The variability of change in effective diameters was 10.6%; for change rates of RECIST maximum diameter variability was 27.5%. Conclusion: Semi-automated volumetric analysis allows fast and convenient segmentation of most lymph node metastases. Compared with RECIST the inter-observer-variability in baseline and follow-up is reduced. This should principally allow subtle changes to be subclassified within the RECIST stable range as minor response [-15% to +10%].

Published
2011

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