14 results on '"Bidari K"'
Search Results
2. BRAF V600 mutation profiling in primary skin nodular melanoma in Indonesia: an analysis using high resolution pyrosequencing
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Hanggoro Tri Rinonce, Rovi Panji Mustiko Aji, Ni’mah Hayati, Maria Fransiska Pudjohartono, Bidari Kameswari, Sumadi Lukman Anwar, and Irianiwati
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Melanoma ,Skin cancer ,BRAF ,Pyrosequencing ,Indonesia ,Medicine ,Biology (General) ,QH301-705.5 ,Science (General) ,Q1-390 - Abstract
Abstract Objective We aimed to investigate the prevalence and type of BRAF V600 mutations and the associations with clinicopathological variables in primary skin nodular melanoma cases in Yogyakarta and Central Java, Indonesia using pyrosequencing. Results BRAF V600 mutations of the V600E type were found in 21 (53.85%) specimens. The variant allele frequencies (VAFs) ranged from 5.07 to 94.70%, averaging 29.05%. However, most cases had low VAFs, with 13 (61.9%) specimens below 20% and 4 (19.05%) below 10%.
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- 2020
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3. The frequency and clinicopathological significance of NRAS mutations in primary cutaneous nodular melanoma in Indonesia
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Hanggoro Tri Rinonce, Deflen Jumatul Sastri, Fita Trisnawati, Bidari Kameswari, Paranita Ferronika, and Irianiwati
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Indonesia ,nodular melanoma ,NRAS mutation ,RAS gene family ,skin tumor ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Melanoma is a lethal skin malignancy with a high risk of metastasis, which prompts a need for research on treatment targets and prognostic factors. Recent studies show that the presence of neuroblastoma RAS viral oncogene homolog (NRAS) mutation can influence cell growth in melanomas. The NRAS mutation, which stimulates the mitogen‐activated protein kinase (MAPK) signaling pathway, is associated with a lower survival rate. However, evidence from Indonesia population is still very rare. Further understanding of the role of NRAS mutations in Indonesian melanoma cases will be crucial in developing new management strategies for melanoma patients with NRAS mutations. Aims To explore the frequency of NRAS mutations and their clinicopathological associations in patients with primary nodular cutaneous melanoma in Central Java and Yogyakarta, Indonesia. Methods and results Fifty‐one paraffin‐embedded tissue samples were collected from primary nodular skin melanoma cases between 2011 and 2019 from the two largest referral hospitals in Yogyakarta and Central Java, Indonesia. The NRAS mutation status was evaluated using qualitative real‐time polymerase chain reaction (qRT‐PCR). The association of NRAS mutation was analyzed with the following: age, gender, location, lymph node metastasis, ulceration, mitotic index, tumor‐infiltrating lymphocytes (TILs), necrosis, tumor thickness, lymphovascular invasion (LVI), and tumor size. NRAS mutations were detected in 10 (19.6%) samples and predominantly observed (60%) in exon 2 (G12). These mutations were significantly correlated with lymph node metastases (p = .000); however, they were not associated with other variables analyzed in this study. Conclusions The prevalence of NRAS mutations in primary nodular cutaneous melanoma cases from Indonesia is consistent with previous studies and is significantly associated with increased lymph node metastases. However, the predominant mutation detected in exon 2 (G12) is different from previous studies conducted in other countries. This suggests that melanoma cases in Javanese people have different characteristics from other ethnicities.
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- 2022
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4. Low BRAF V600 mutation prevalence in primary skin nodular melanoma in Indonesia: a real-time PCR detection among Javanese patients
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Hanggoro Tri Rinonce, Rovi Panji Mustiko Aji, Ni’mah Hayati, Maria Fransiska Pudjohartono, Bidari Kameswari, and Irianiwati
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Nodular melanoma ,Skin tumor ,BRAF ,BRAF V600 mutation ,Indonesia ,Medicine ,Science - Abstract
Abstract Background Cutaneous melanoma is a rare, aggressive skin malignancy with a high mortality rate. Although only contributing 7.6% of the cases worldwide, Asia is responsible for 18.6% of deaths from cutaneous melanoma. BRAF V600 mutation presents a potential prognostic predictor in melanoma. Unfortunately, studies on that mutation in melanoma, particularly nodular subtype, in Indonesia are still scarce. This research aimed to investigate the prevalence of BRAF V600 mutation in primary skin nodular melanoma in Yogyakarta and Central Java, Indonesia. Its association with clinicopathological parameters was also analyzed. Methods Forty paraffin-embedded tissue samples from primary skin nodular melanoma cases in 2011–2018 were collected from the two biggest referral hospitals in Yogyakarta and Central Java, Indonesia. The BRAF V600 mutation status was assessed using qualitative real-time PCR and its associations with age, sex, anatomic location, lymph node metastasis, tumor thickness, ulceration, mitotic index, necrosis, lymphovascular invasion, and tumor-infiltrating lymphocytes were analyzed. Results BRAF V600 mutations were found in 4 (10%) samples. These mutations were significantly associated with the central (non-extremity) region (p = 0.013) and presence of lymphovascular invasion (p = 0.005). However, it was not associated with any other variables analyzed in this study. Conclusion The prevalence of BRAF V600 mutation in Indonesian primary skin nodular melanoma cases is low and significantly associated with anatomic location and lymphovascular invasion. It is lower than prevalences in other Asian populations as well as in Caucasian populations and suggests that melanoma cases in Javanese people may have distinct clinicopathological characteristics from other Asian ethnicities.
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- 2019
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5. The Surface Coating of Polyurethane Substrates, Part 3: Some Properties of Polyurethane Surfaces and Interfaces
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Heath, R.J., primary and Bidari, K., additional
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- 1990
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6. The Surface Coating of Polyurethane Substrates, Part 1: A Review of Processing Practices from Theoretical Concepts
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Heath, R.J. and Bidari, K.
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Polyurethane (PU) foam products are now manufactured to meet demanding end property requirements and to compete with other polymers. For external uses, common PUs, i.e. those based on aromatic isocyanates, are prone to environmental attack, promoted by ultra violet and oxidative degradation. Increased resistance can be produced by the incorporation of anti-degradants but these have limitations. Equally the use of non-aromatic isocyanate based foams is commercially uneconomic. Therefore there is increased use of surface coatings to act as weather proofing barriers to PU foams.Four examples of the manufacture of coated PU products are given. Within each there has to be strict controls to ensure the finished article has good appearance and the desired properties. This means that the PU substrate has to be prepared and the surface coating carefully selected to maximise the properties of the resulting PU/PU composite. Generally techniques have been developed on a trial and error basis but fortunately, the currently used systems appear to follow reasonably sound surface science principles, as the second paper in this series will discuss.It is argued that painting of a PU moulding is a relatively expensive, labour intensive operation and the so-called in-mould technique has many advantages. However, there are limitations within all the coating processes involving PUs and it is hoped that the colour fastness of cheaper foam systems will be improved in the near future.
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- 1987
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7. The Surface Coating of Polyurethane Substrates, Part 2: A Theoretical Approach to the Interfacial Bonding of Polyurethane Coatings on Polyurethane Substrates
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Heath, R.J. and Bidari, K.
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In the first paper of this series a number of manufacturing techniques were reviewed from first hand observations of such practices. Comments were made of the techniques which had evolved on a trial and error basis to optimise the properties of the paint and PU foam substrate composite.In this paper, the wetting and interfacial bonding phenomena developed in these composites is examined on the basis of currently accepted surface science theories. Wetting and spreading over a surface, followed by interfacial bonding will depend on the initial affinity between the liquid and the solid, although there might be variation from that predicted because of composition changes as the paint system dries. It is suggested for a PU foam/PU surface coating composite, that good adhesive bonding results from a combination of dispersion, polar and covalent bonding interactions. However, because of moulding practice, boundary layers (e.g. release agent residues) and other phenomenon will interfere with the wetting and bonding in some of these systems.In-mould surface coating has certain advantages over other methods of painting a moulding. In particular the chemical activity of freshly produced surfaces minimises the possibility of boundary layer effects. The spreading pressure, π, which influences surface tension in a system, will be affected by the moulding pressure.Later papers will report on the examination of various PU/PU combinations, describing the influences and optimisation of the adhesive bond between coating and foam substrate.
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- 1987
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8. Randomized Comparison of 3 High-Level Disinfection and Sterilization Procedures for Duodenoscopes.
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Snyder GM, Wright SB, Smithey A, Mizrahi M, Sheppard M, Hirsch EB, Chuttani R, Heroux R, Yassa DS, Olafsdottir LB, Davis RB, Anastasiou J, Bapat V, Bidari K, Pleskow DK, Leffler D, Lane B, Chen A, Gold HS, Bartley A, King AD, and Sawhney MS
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- Bacteriological Techniques, Cross Infection microbiology, Cross Infection transmission, Duodenoscopes adverse effects, Duodenoscopy adverse effects, Gases, Humans, Prospective Studies, Time Factors, Cross Infection prevention & control, Disinfectants, Disinfection methods, Drug Resistance, Multiple, Bacterial, Duodenoscopes microbiology, Duodenoscopy instrumentation, Equipment Contamination prevention & control, Equipment Reuse, Ethylene Oxide, Sterilization methods, o-Phthalaldehyde
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Background and Aims: Duodenoscopes have been implicated in the transmission of multidrug-resistant organisms (MDRO). We compared the frequency of duodenoscope contamination with MDRO or any other bacteria after disinfection or sterilization by 3 different methods., Methods: We performed a single-center prospective randomized study in which duodenoscopes were randomly reprocessed by standard high-level disinfection (sHLD), double high-level disinfection (dHLD), or standard high-level disinfection followed by ethylene oxide gas sterilization (HLD/ETO). Samples were collected from the elevator mechanism and working channel of each duodenoscope and cultured before use. The primary outcome was the proportion of duodenoscopes with an elevator mechanism or working channel culture showing 1 or more MDRO; secondary outcomes included the frequency of duodenoscope contamination with more than 0 and 10 or more colony-forming units (CFU) of aerobic bacterial growth on either sampling location., Results: After 3 months of enrollment, the study was closed because of the futility; we did not observe sufficient events to evaluate the primary outcome. Among 541 duodenoscope culture events, 516 were included in the final analysis. No duodenoscope culture in any group was positive for MDRO. Bacterial growth of more than 0 CFU was noted in 16.1% duodenoscopes in the sHLD group, 16.0% in the dHLD group, and 22.5% in the HLD/ETO group (P = .21). Bacterial growth or 10 or more CFU was noted in 2.3% of duodenoscopes in the sHLD group, 4.1% in the dHLD group, and 4.2% in the HLD/ETO group (P = .36). MRDOs were cultured from 3.2% of pre-procedure rectal swabs and 2.5% of duodenal aspirates., Conclusions: In a comparison of duodenoscopes reprocessed by sHLD, dHLD, or HLD/ETO, we found no significant differences between groups for MDRO or bacteria contamination. Enhanced disinfection methods (dHLD or HLD/ETO) did not provide additional protection against contamination. However, insufficient events occurred to assess our primary study end-point. ClinicalTrials.gov no: NCT02611648., (Copyright © 2017 AGA Institute. Published by Elsevier Inc. All rights reserved.)
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- 2017
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9. Recurrence of Barrett's Esophagus is Rare Following Endoscopic Eradication Therapy Coupled With Effective Reflux Control.
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Komanduri S, Kahrilas PJ, Krishnan K, McGorisk T, Bidari K, Grande D, Keefer L, and Pandolfino J
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- Aged, Barrett Esophagus prevention & control, Carcinoma in Situ prevention & control, Cohort Studies, Endoscopy, Digestive System, Esophageal Neoplasms prevention & control, Female, Hernia, Hiatal epidemiology, Humans, Logistic Models, Male, Middle Aged, Multivariate Analysis, Neoplasm Recurrence, Local epidemiology, Prospective Studies, Recurrence, Risk Factors, Barrett Esophagus surgery, Carcinoma in Situ surgery, Endoscopic Mucosal Resection methods, Esophageal Neoplasms surgery, Gastroesophageal Reflux drug therapy, Neoplasm Recurrence, Local prevention & control, Proton Pump Inhibitors therapeutic use
- Abstract
Objectives: Recent data suggest that effective control of gastroesophageal reflux improves outcomes associated with endoscopic eradication therapy (EET) for Barrett's esophagus (BE). However, the impact of reflux control on preventing recurrent intestinal metaplasia and/or dysplasia is unclear. The aims of the study were: (a) to determine the effectiveness and durability of EET under a structured reflux management protocol and (b) to determine the impact of optimizing anti-reflux therapy on achieving complete eradication of intestinal metaplasia (CE-IM)., Methods: Consecutive BE patients referred for EET were enrolled and managed with a standardized reflux management protocol including twice-daily PPI therapy during eradication. Primary outcomes were rates of CE-IM and IM or dysplasia recurrence., Results: Out of 221 patients enrolled (46.0% with high-grade dysplasia/intramucosal carcinoma, 34.0% with low-grade dysplasia, and 20.0% with non-dysplastic BE) an overall CE-IM of 93% was achieved within 11.6±10.2 months. Forty-eight patients did not achieve CE-IM in 3 sessions. After modification of their reflux management, 45 (93.7%) achieved CE-IM in a mean of 1.1 RFA sessions. Recurrence occurred in 13 patients (IM in 10(4.8%), dysplasia in 3 (1.5%)) during a mean follow-up of 44±18.5 months. The only significant predictor of recurrence was the presence of a hiatal hernia. Recurrence of IM was significantly lower than historical controls (10.9 vs. 4.8%, P=0.04)., Conclusions: The current study highlights the importance of reflux control in patients with BE undergoing EET. In this setting, EET has long-term durability with low recurrence rates providing early evidence for extending endoscopic surveillance intervals after EET.
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- 2017
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10. The Clinical Utility of Evaluating the Luminal Upper Gastrointestinal Tract During Linear Endoscopic Ultrasonography.
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Kim S, Hamerski C, Ghassemi K, Shah J, Bhat Y, Klapman J, Komanduri S, Keswani RN, Bidari K, Wani S, Watson RR, and Muthusamy VR
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- Biopsy methods, Cohort Studies, Endoscopes, Endoscopy, Digestive System instrumentation, Endosonography instrumentation, Female, Gastrointestinal Diseases pathology, Gastroscopes, Humans, Male, Middle Aged, Prospective Studies, Upper Gastrointestinal Tract pathology, Endoscopy, Digestive System methods, Endosonography methods, Gastrointestinal Diseases diagnostic imaging, Upper Gastrointestinal Tract diagnostic imaging
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Background: The clinical utility of performing esophagogastroduodenoscopy (EGD) before linear endoscopic ultrasonography (L-EUS) to evaluate the luminal upper gastrointestinal (GI) tract is not well established., Goals: The study was aimed to determine the prevalence of clinically meaningful luminal abnormalities (any luminal finding requiring further evaluation with mucosal biopsy or initiation of treatment) in patients undergoing L-EUS. The study also sought to compare the ability of the gastroscope and the linear echoendoscope in identifying these lesions., Study: A prospective, multicenter cohort study enrolled patients undergoing L-EUS for nonluminal indications. All patients underwent EGD followed by L-EUS by 2 different endoscopists. The second endoscopist was blinded to the results of the initial EGD. The identification of clinically meaningful luminal lesions and quality of endoscopic visualization of the upper GI tract were measured., Results: In the cohort of 175 patients, 52 (29.7%) patients had clinically meaningful luminal findings seen in the upper GI tract. There was no significant difference in the number of clinically meaningful lesions identified on EGD and L-EUS (25.1% vs. 22.9%, P=0.39). No significant difference was found in the miss rate of clinically meaningful lesions between the 2 modalities (EGD: 4.5% vs. EUS: 6.9%, P=0.39)., Conclusions: A substantial minority of patients undergoing L-EUS for nonluminal indications will have clinically meaningful luminal findings. The endoscopic evaluation of the luminal upper GI tract can be adequately achieved using the linear echoendoscope.
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- 2016
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11. Plastic biliary stent patency in patients with locally advanced pancreatic adenocarcinoma receiving downstaging chemotherapy.
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Ge PS, Hamerski CM, Watson RR, Komanduri S, Cinnor BB, Bidari K, Klapman JB, Lin CL, Shah JN, Wani S, Donahue TR, and Muthusamy VR
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- Aged, Antineoplastic Agents therapeutic use, Cholestasis diagnosis, Cholestasis etiology, Cholestasis prevention & control, Endoscopy, Equipment Design, Equipment Failure, Female, Follow-Up Studies, Humans, Male, Middle Aged, Retrospective Studies, Treatment Outcome, Adenocarcinoma pathology, Adenocarcinoma therapy, Pancreatic Neoplasms pathology, Pancreatic Neoplasms therapy, Plastics, Stents
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Background: Plastic stents in patients with biliary obstruction caused by pancreatic adenocarcinoma are typically exchanged at 3-month intervals. Plastic stents may have reduced durability in patients receiving chemotherapy., Objective: To determine the duration of plastic biliary stent patency in patients undergoing chemotherapy for pancreatic adenocarcinoma., Design: Retrospective, multicenter cohort study., Setting: Three tertiary academic referral centers., Patients: A total of 173 patients receiving downstaging chemotherapy for locally advanced or borderline resectable pancreatic adenocarcinoma from 1996 to 2013., Interventions: Placement of 10F or larger plastic biliary stents., Main Outcome Measurements: Primary outcome was overall duration of stent patency. Secondary outcomes included the incidence of premature stent exchange (because of cholangitis or jaundice) and hospitalization rates., Results: A total of 233 plastic stents were placed, and the overall median duration of stent patency was 53 days (interquartile range [IQR] 25-99 days). Eighty-seven stents were removed at the time of surgical resection, and 63 stents were exchanged routinely per protocol. The remaining 83 stent exchanges were performed for worsening liver function test results, jaundice, or cholangitis, representing a 35.6% rate of premature stent exchange. The median stent patency duration in the premature stent exchange group was 49 days (IQR 25-91 days) with a 44.6% hospitalization rate. The overall rate of cholangitis was 15.0% of stent exchanges, occurring a median of 56 days after stent placement (IQR 26-89 days)., Limitations: Retrospective study., Conclusions: Plastic biliary stents placed during chemotherapy/chemoradiation for pancreatic adenocarcinoma have a shorter-than-expected patency duration, and a substantial number of patients will require premature stent exchange. Consideration should be given to shortening the interval for plastic biliary stent exchange., (Copyright © 2015 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.)
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- 2015
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12. Biliary Obstruction After Transjugular Intrahepatic Portosystemic Shunt Placement in a Patient With Budd-Chiari Syndrome.
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Korrapati P, Bidari K, and Komanduri S
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A 20-year-old male presented with 2 months of progressive abdominal distension due to ascites and Budd-Chiari syndrome. He underwent transjugular intrahepatic portosystemic shunt (TIPS) placement, but soon after had elevated liver enzymes. MRCP revealed mild left intrahepatic biliary dilatation without stones or obvious stricture. Endoscopic retrograde cholangiopancreatography (ERCP) demonstrated a focal stricture due to compression by the TIPS. The stricture was dilated and a 10 Fr x 15-cm plastic stent was placed with excellent biliary drainage. The patient's symptoms and liver tests normalized within 1 week. This is the first case of biliary obstruction due to TIPS placement effectively managed by ERCP.
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- 2015
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13. High-resolution manometry studies are frequently imperfect but usually still interpretable.
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Roman S, Kahrilas PJ, Boris L, Bidari K, Luger D, and Pandolfino JE
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- Diagnostic Errors statistics & numerical data, Humans, Esophageal Diseases diagnosis, Health Services Research, Manometry methods
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Background & Aims: Clinical esophageal manometry can be technically challenging. We investigated the prevalence and causes of technically imperfect, high-resolution esophageal pressure topography (EPT) studies at a tertiary referral hospital., Methods: We reviewed 2000 consecutive clinical EPT studies that had been performed with consistent technique and protocol. A study was considered technically imperfect if there was a problem with pressure signal acquisition, if the catheter did not pass through the esophagogastric junction (EGJ), or if there were fewer than 7 evaluable swallows (without double-swallowing, and so forth). Data from the technically imperfect studies were interpreted blindly to determine a diagnosis; this diagnosis was compared with the diagnosis based on chart review., Results: We identified 414 technically imperfect studies (21% of the series). These were attributed to fewer than 7 evaluable swallows (58%), inability to traverse the EGJ (29%), sensor or thermal compensation malfunction (7%), and miscellaneous artifacts (6%). The most frequent causes of failure to traverse the EGJ were a large hiatal hernia (50%) and achalasia (24%). The condition most frequently associated with an incomplete swallow protocol was achalasia (33%). Despite the limitations, the diagnosis of achalasia was achieved correctly by blinded interpretation in 77% of cases and nonblinded interpretation in 94% of cases., Conclusions: Technically imperfect EPT studies are common in a tertiary care center; large hiatal hernia and achalasia were the most frequent causes. However, despite the technical limitations, the data still could be interpreted, especially in the context of associated endoscopic and radiographic data., (Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.)
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- 2011
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14. Distal esophageal spasm in high-resolution esophageal pressure topography: defining clinical phenotypes.
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Pandolfino JE, Roman S, Carlson D, Luger D, Bidari K, Boris L, Kwiatek MA, and Kahrilas PJ
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- Deglutition physiology, Esophageal Spasm, Diffuse physiopathology, Humans, Pressure, Retrospective Studies, Esophageal Spasm, Diffuse diagnosis, Manometry methods, Muscle Contraction physiology, Muscle, Smooth physiopathology
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Background: The manometric diagnosis of distal esophageal spasm (DES) uses "simultaneous contractions" as a defining criterion, ignoring the concept of short latency distal contractions as an important feature. Our aim was to apply standardized metrics of contraction velocity and latency to high-resolution esophageal pressure topography (EPT) studies to refine the diagnosis of DES., Methods: Two thousand consecutive EPT studies were analyzed for contractile front velocity (CFV) and distal latency to identify patients potentially having DES. Normal limits for CFV and distal latency were established from 75 control subjects. Clinical data of patients with reduced distal latency and/or rapid CFV were reviewed., Results: Of 1070 evaluable patients, 91 (8.5%) had a high CFV and/or low distal latency. Patients with only rapid contractions (n = 186 [17.4%] using conventional manometry criteria; n = 85 [7.9%] using EPT criteria) were heterogeneous in diagnosis and symptoms, with the majority ultimately categorized as weak peristalsis or normal. In contrast, 96% of patients with premature contraction had dysphagia, and all (n = 24; 2.2% overall) were ultimately managed as spastic achalasia or DES., Conclusions: The current DES diagnostic paradigm focused on "simultaneous contractions" identifies a large heterogeneous set of patients, most of whom do not have a clinical syndrome suggestive of esophageal spasm. Incorporating distal latency into the diagnostic algorithm of EPT studies improves upon this by isolating disorders of homogeneous pathophysiology: DES with short latency and spastic achalasia. We hypothesize that prioritizing measurement of distal latency will refine the management of these disorders, recognizing that outcomes trials are necessary., (Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.)
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- 2011
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