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Multiple sclerosis is a chronic autoimmune disease that affects the central nervous system. Understanding multiple sclerosis progression and identifying the implicated brain structures is crucial for personalized treatment decisions. Deformation-based morphometry utilizes anatomical magnetic resonance imaging to quantitatively assess volumetric brain changes at the voxel level, providing insight into how each brain region contributes to clinical progression with regards to neurodegeneration. Utilizing such voxel-level data from a relapsing multiple sclerosis clinical trial, we extend a model-agnostic feature importance metric to identify a robust and predictive feature set that corresponds to clinical progression. These features correspond to brain regions that are clinically meaningful in MS disease research, demonstrating their scientific relevance. When used to predict progression using classical survival models and 3D convolutional neural networks, the identified regions led to the best-performing models, demonstrating their prognostic strength. We also find that these features generalize well to other definitions of clinical progression and can compensate for the omission of highly prognostic clinical features, underscoring the predictive power and clinical relevance of deformation-based morphometry as a regional identification tool.

This paper explores how Large Language Models (LLMs) can automate consensus-seeking in supply chain management (SCM), where frequent decisions on problems such as inventory levels and delivery times require coordination among companies. Traditional SCM relies on human consensus in decision-making to avoid emergent problems like the bullwhip effect. Some routine consensus processes, especially those that are time-intensive and costly, can be automated. Existing solutions for automated coordination have faced challenges due to high entry barriers locking out SMEs, limited capabilities, and limited adaptability in complex scenarios. However, recent advances in Generative AI, particularly LLMs, show promise in overcoming these barriers. LLMs, trained on vast datasets can negotiate, reason, and plan, facilitating near-human-level consensus at scale with minimal entry barriers. In this work, we identify key limitations in existing approaches and propose autonomous LLM agents to address these gaps. We introduce a series of novel, supply chain-specific consensus-seeking frameworks tailored for LLM agents and validate the effectiveness of our approach through a case study in inventory management. To accelerate progress within the SCM community, we open-source our code, providing a foundation for further advancements in LLM-powered autonomous supply chain solutions.

Thermocapillary convection is particularly effective for the control of thin liquid film topography or for the actuation of microparticles at the liquid-air interface. Experiments with water are challenging, however, as its interface is prone to contamination by surface-active impurities that profoundly alter its hydrodynamic response. Despite numerous reports highlighting the hindrance of thermocapillary flows, quantitative information on interface contamination is definitely lacking. We therefore introduce a general framework in order to account for the presence of a low concentration of insoluble surfactants at the water-air interface. Focusing on the low-compressibility limit, we identify the inverse Marangoni number as the appropriate small parameter in the modeling. The transport equations can then be linearized without any further assumption regarding the other dimensionless groups. It is shown in particular that the surfactant concentration adapts to the thermocapillary forcing in order to cancel the interfacial viscous stress. Several experimentally relevant situations are discussed with emphasis on physical observables. Besides the excellent agreement between theory and experiment, our predictions provide a quantitative assessment of the impurity concentration.

We present Bidirectional Gaussian Primitives, an image-based novel view synthesis technique designed to represent and render 3D objects with surface and volumetric materials under dynamic illumination. Our approach integrates light intrinsic decomposition into the Gaussian splatting framework, enabling real-time relighting of 3D objects. To unify surface and volumetric material within a cohesive appearance model, we adopt a light- and view-dependent scattering representation via bidirectional spherical harmonics. Our model does not use a specific surface normal-related reflectance function, making it more compatible with volumetric representations like Gaussian splatting, where the normals are undefined. We demonstrate our method by reconstructing and rendering objects with complex materials. Using One-Light-At-a-Time (OLAT) data as input, we can reproduce photorealistic appearances under novel lighting conditions in real time.

We present a computational approach for unfolding 3D shapes isometrically into the plane as a single patch without overlapping triangles. This is a hard, sometimes impossible, problem, which existing methods are forced to soften by allowing for map distortions or multiple patches. Instead, we propose a geometric relaxation of the problem: we modify the input shape until it admits an overlap-free unfolding. We achieve this by locally displacing vertices and collapsing edges, guided by the unfolding process. We validate our algorithm quantitatively and qualitatively on a large dataset of complex shapes and show its proficiency by fabricating real shapes from paper., Comment: 12 pages, 12 figures

Achieving photorealistic 3D view synthesis and relighting of human portraits is pivotal for advancing AR/VR applications. Existing methodologies in portrait relighting demonstrate substantial limitations in terms of generalization and 3D consistency, coupled with inaccuracies in physically realistic lighting and identity preservation. Furthermore, personalization from a single view is difficult to achieve and often requires multiview images during the testing phase or involves slow optimization processes. This paper introduces Lite2Relight, a novel technique that can predict 3D consistent head poses of portraits while performing physically plausible light editing at interactive speed. Our method uniquely extends the generative capabilities and efficient volumetric representation of EG3D, leveraging a lightstage dataset to implicitly disentangle face reflectance and perform relighting under target HDRI environment maps. By utilizing a pre-trained geometry-aware encoder and a feature alignment module, we map input images into a relightable 3D space, enhancing them with a strong face geometry and reflectance prior. Through extensive quantitative and qualitative evaluations, we show that our method outperforms the state-of-the-art methods in terms of efficacy, photorealism, and practical application. This includes producing 3D-consistent results of the full head, including hair, eyes, and expressions. Lite2Relight paves the way for large-scale adoption of photorealistic portrait editing in various domains, offering a robust, interactive solution to a previously constrained problem. Project page: https://vcai.mpi-inf.mpg.de/projects/Lite2Relight/, Comment: Accepted at SIGGRAPH '24: ACM SIGGRAPH 2024 Conference Papers

Given a polynomial $p$ with no zeros in the polydisk, or equivalently the poly-upper half-plane, we study the problem of determining the ideal of polynomials $q$ with the property that the rational function $q/p$ is bounded near a boundary zero of $p$. We give a complete description of this ideal of numerators in the case where the zero set of $p$ is smooth and satisfies a non-degeneracy condition. We also give a description of the ideal in terms of an integral closure when $p$ has an isolated zero on the distinguished boundary. Constructions of multivariate stable polynomials are presented to illustrate sharpness of our results and necessity of our assumptions., Comment: 16 pages. Final version incorporating referee comments

The NASA Lunar Reconnaissance Orbiter (LRO) has returned petabytes of lunar high spatial resolution surface imagery over the past decade, impractical for humans to fully review manually. Here we develop an automated method using a deep generative visual model that rapidly retrieves scientifically interesting examples of LRO surface imagery representing the first planetary image anomaly detector. We give quantitative experimental evidence that our method preferentially retrieves anomalous samples such as notable geological features and known human landing and spacecraft crash sites. Our method addresses a major capability gap in planetary science and presents a novel way to unlock insights hidden in ever-increasing remote sensing data archives, with numerous applications to other science domains. We publish our code and data along with this paper., Comment: 15 pages, 10 figures - JSTARS, accepted

Independent Component Analysis (ICA) was introduced in the 1980's as a model for Blind Source Separation (BSS), which refers to the process of recovering the sources underlying a mixture of signals, with little knowledge about the source signals or the mixing process. While there are many sophisticated algorithms for estimation, different methods have different shortcomings. In this paper, we develop a nonparametric score to adaptively pick the right algorithm for ICA with arbitrary Gaussian noise. The novelty of this score stems from the fact that it just assumes a finite second moment of the data and uses the characteristic function to evaluate the quality of the estimated mixing matrix without any knowledge of the parameters of the noise distribution. In addition, we propose some new contrast functions and algorithms that enjoy the same fast computability as existing algorithms like FASTICA and JADE but work in domains where the former may fail. While these also may have weaknesses, our proposed diagnostic, as shown by our simulations, can remedy them. Finally, we propose a theoretical framework to analyze the local and global convergence properties of our algorithms.

The physical properties of an object, such as mass, significantly affect how we manipulate it with our hands. Surprisingly, this aspect has so far been neglected in prior work on 3D motion synthesis. To improve the naturalness of the synthesized 3D hand object motions, this work proposes MACS the first MAss Conditioned 3D hand and object motion Synthesis approach. Our approach is based on cascaded diffusion models and generates interactions that plausibly adjust based on the object mass and interaction type. MACS also accepts a manually drawn 3D object trajectory as input and synthesizes the natural 3D hand motions conditioned by the object mass. This flexibility enables MACS to be used for various downstream applications, such as generating synthetic training data for ML tasks, fast animation of hands for graphics workflows, and generating character interactions for computer games. We show experimentally that a small-scale dataset is sufficient for MACS to reasonably generalize across interpolated and extrapolated object masses unseen during the training. Furthermore, MACS shows moderate generalization to unseen objects, thanks to the mass-conditioned contact labels generated by our surface contact synthesis model ConNet. Our comprehensive user study confirms that the synthesized 3D hand-object interactions are highly plausible and realistic.

This paper studies the level set Crouzeix conjecture, which is a weak version of Crouzeix's conjecture that applies to finite compressions of the shift. Amongst other results, this paper establishes the level set Crouzeix conjecture for several classes of $3\times3$, $4\times4$, and $5\times5$ matrices associated to compressions of the shift via a geometric analysis of their numerical ranges. This paper also establishes Crouzeix's conjecture for several classes of nilpotent matrices whose studies are motivated by related compressions of shifts., Comment: 28 pages

During the cutting process, material of the workpiece is continuously being removed by the cutting tool, which results in a reduction of mass as well as a displacement in the center of the workpiece mass. When using workpiece sided force sensors, such as table dynamometers, the total mass and the displacement of the center of mass affects the force measurement due to gravitational and inertial effects. The high flexibility of the milling process leads to a complex change of volume and mass and necessitates the consideration of the engagement conditions between tool and workpiece along the tool path in order to estimate changes in mass and center of mass. This paper proposes a method for estimating the mass loss and the displacement of the center of mass during multi-axis milling processes. In this method the tool gets numerically sliced along the tool axis and the workpiece removal for each slice along an arbitrary tool path gets calculated. To validate the mass loss model, experiments in both three-axis milling as well as multi-axis milling processes have been conducted. Since it is difficult to measure the center of mass, validation for the displacement of the center of mass was done by comparison with data extracted from CAD. The results show good agreement between the simulated and measured mass loss using the proposed approach.

Recent years have witnessed a steep increase in linguistic databases capturing syntactic variation. We survey and describe 21 publicly available morpho-syntactic databases, focusing on such properties as data structure, user interface, documentation, formats, and overall user friendliness. We demonstrate that all the surveyed databases can be fruitfully categorized along two dimensions: units of description and the design principle. Units of description refer to the type of the data the database represents (languages, constructions, or expressions). The design principles capture the internal logic of the database. We identify three primary design principles, which vary in their descriptive power, granularity, and complexity: monocategorization, multicategorization, and structural decomposition. We describe how these design principles are implemented in concrete databases and discuss their advantages and limitations. Finally, we outline essential desiderata for future modern databases in linguistics.

Literacy, or the ability to read and write, is a crucial indicator of success in life and greater society. It is estimated that 85% of people in juvenile delinquent systems cannot adequately read or write, that more than half of those with substance abuse issues have complications in reading or writing and that two-thirds of those who do not complete high school lack proper literacy skills. Furthermore, young children who do not possess reading skills matching grade level by the fourth grade are approximately 80% likely to not catch up at all. Many may believe that in a developed country such as the United States, literacy fails to be an issue; however, this is a dangerous misunderstanding. Globally an estimated 1.19 trillion dollars are lost every year due to issues in literacy; in the USA, the loss is an estimated 300 billion. To put it in more shocking terms, one in five American adults still fail to comprehend basic sentences. Making matters worse, the only tools available now to correct a lack of reading and writing ability are found in expensive tutoring or other programs that oftentimes fail to be able to reach the required audience. In this paper, our team puts forward a new way of teaching English spelling and word recognitions to grade school students in the United States: Wordification. Wordification is a web application designed to teach English literacy using principles of linguistics applied to the orthographic and phonological properties of words in a manner not fully utilized previously in any computer-based teaching application., Comment: 8 pages, 7 figures, IEEE International Conference on Frontiers in Education

Statistical network analysis primarily focuses on inferring the parameters of an observed network. In many applications, especially in the social sciences, the observed data is the groups formed by individual subjects. In these applications, the network is itself a parameter of a statistical model. Zhao and Weko (2019) propose a model-based approach, called the hub model, to infer implicit networks from grouping behavior. The hub model assumes that each member of the group is brought together by a member of the group called the hub. The set of members which can serve as a hub is called the hub set. The hub model belongs to the family of Bernoulli mixture models. Identifiability of Bernoulli mixture model parameters is a notoriously difficult problem. This paper proves identifiability of the hub model parameters and estimation consistency under mild conditions. Furthermore, this paper generalizes the hub model by introducing a model component that allows hubless groups in which individual nodes spontaneously appear independent of any other individual. We refer to this additional component as the null component. The new model bridges the gap between the hub model and the degenerate case of the mixture model -- the Bernoulli product. Identifiability and consistency are also proved for the new model. In addition, a penalized likelihood approach is proposed to estimate the hub set when it is unknown., Comment: arXiv admin note: substantial text overlap with arXiv:2004.09709

The interest in exploring planetary bodies for scientific investigation and in-situ resource utilization is ever-rising. Yet, many sites of interest are inaccessible to state-of-the-art planetary exploration robots because of the robots' inability to traverse steep slopes, unstructured terrain, and loose soil. Additionally, current single-robot approaches only allow a limited exploration speed and a single set of skills. Here, we present a team of legged robots with complementary skills for exploration missions in challenging planetary analog environments. We equipped the robots with an efficient locomotion controller, a mapping pipeline for online and post-mission visualization, instance segmentation to highlight scientific targets, and scientific instruments for remote and in-situ investigation. Furthermore, we integrated a robotic arm on one of the robots to enable high-precision measurements. Legged robots can swiftly navigate representative terrains, such as granular slopes beyond 25 degrees, loose soil, and unstructured terrain, highlighting their advantages compared to wheeled rover systems. We successfully verified the approach in analog deployments at the BeyondGravity ExoMars rover testbed, in a quarry in Switzerland, and at the Space Resources Challenge in Luxembourg. Our results show that a team of legged robots with advanced locomotion, perception, and measurement skills, as well as task-level autonomy, can conduct successful, effective missions in a short time. Our approach enables the scientific exploration of planetary target sites that are currently out of human and robotic reach.

The unsteady hydrodynamic drag exerted on an oscillating sphere near a planar wall is addressed experimentally, theoretically, and numerically. The experiments are performed by using colloidal-probe Atomic Force Microscopy (AFM) in thermal noise mode. The natural resonance frequencies and quality factors are extracted from the measurement of the power spectrum density of the probe oscillation for a broad range of gap distances and Womersley numbers. The shift in the natural resonance frequency of the colloidal probe as the probe goes close to a solid wall infers the wall-induced variations of the effective mass of the probe. Interestingly, a crossover from a positive to a negative shift is observed as the Womersley number increases. In order to rationalize the results, the confined unsteady Stokes equation is solved numerically using a finite-element method, as well as asymptotic calculations.The in-phase and out-of-phase terms of the hydrodynamic drag acting on the sphere are obtained and agree well to the experimental results. All together, the experimental, theoretical, and numerical results show that the hydrodynamic force felt by an immersed sphere oscillating near a wall is highly dependent on the Womersley number.