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1,109 results on '"Bickel, H."'

1. Profile gedeckter und ungedeckter Versorgungsbedarfe der hochaltrigen Hausarztpatient:innen mit kognitiven Beeinträchtigungen und Demenz - Ergebnisse der AgeCoDe und AgeQualiDe Studie

Author

Kraake, S, Pabst, A, Bickel, H, Pentzek, M, Fuchs, A, Wiese, B, Oey, A, König, HH, Brettschneider, C, Scherer, M, Mallon, T, Lühmann, D, Maier, W, Wagner, M, Heser, K, Weyerer, S, Werle, J, Riedel-Heller, SG, Stein, J, Kraake, S, Pabst, A, Bickel, H, Pentzek, M, Fuchs, A, Wiese, B, Oey, A, König, HH, Brettschneider, C, Scherer, M, Mallon, T, Lühmann, D, Maier, W, Wagner, M, Heser, K, Weyerer, S, Werle, J, Riedel-Heller, SG, and Stein, J

Published
2024

7. Demenzen

Author

Förstl, H., Bickel, H., Perneczky, R., Hüll, M., Daffertshofer, M., and Berlit, Peter, editor

Published
2012
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8. Cerebrospinal fluid biomarkers for Alzheimer’s disease: the role of apolipoprotein E genotype, age, and sex

Author

Mehrabian S, Alexopoulos P, Ortner M, Traykov L, Grimmer T, Kurz A, Förstl H, Bickel H, and Diehl-Schmid J

Subjects
Alzheimer's disease, biomarkers, CSF, Aβ 1-42, ApoE, age, gender, LOAD, EOAD, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Shima Mehrabian,1 Panagiotis Alexopoulos,2,3 Marion Ortner,2 Latchezar Traykov,1 Timo Grimmer,2 Alexander Kurz,2 Hans Förstl,2 Horst Bickel,2 Janine Diehl-Schmid21Department of Neurology, University Hospital “Alexandrovska”, Sofia, Bulgaria; 2Department of Psychiatry, Technische Universität München, Munich, Germany; 3Department of Psychiatry, University of Patras, Patras, GreeceIntroduction: Cerebrospinal fluid (CSF) biomarkers improve the diagnostic accuracy for Alzheimer’s disease (AD), even at the predementia stage of the disease. The ε4-allele of apolipoprotein E (ApoE ε4), female sex, and older age are well-known risk factors for AD. It is unclear how these risk factors affect the CSF biomarkers in patients with AD.Aim: The objective of this study was to investigate the associations of ApoE ε4, sex, and age with CSF biomarker levels in a unicenter sample of patients with AD that includes a high proportion of patients with early-onset AD (EOAD).Methods: The CSF levels of amyloid-β 1-42 (Aβ1-42) and total-tau of 117 subjects with mild to moderate AD (55 late-onset AD and 62 EOAD) were assessed. All subjects underwent ApoE genotyping, clinical evaluation, comprehensive neuropsychological assessments, and neuroimaging. Associations between CSF biomarker levels, ApoE ε4 allele frequency, age, and sex were evaluated.Results: In the whole patient sample and in the late-onset AD subgroup ε4 homozygous subjects had significantly lower CSF Aβ1-42 levels compared with ε4 heterozygous subjects and ε4 noncarriers. This association was not detected in the EOAD group. Age group, sex, and severity of cognitive decline did not have a significant impact on CSF Aβ1-42 levels. No significant associations were found between ApoE ε4 allele frequency and CSF total-tau levels.Conclusion: ApoE ε4 allele is associated with a reduction of CSF Aβ1-42 levels. This result is consistent with the findings of several previous studies. In the subgroup of patients with EOAD this association was not replicated. Larger studies are necessary to further investigate associations between ApoE ε4 allele frequency and CSF biomarker levels in patients with EOAD.Keywords: Alzheimer’s disease, biomarkers, CSF, Aβ1-42, ApoE, LOAD, EOAD, tau

Published
2015

22. Determinanten der Institutionalisierung im Zeitverlauf

Author

Hajek, A, additional, Buczak-Stec, E, additional, Bickel, H, additional, Wiese, B, additional, Weyerer, S, additional, Pentzek, M, additional, Wagner, M, additional, Maier, W, additional, Scherer, M, additional, Riedel-Heller, SG, additional, and König, HH, additional

Published
2021
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24. Multimorbidität und erfolgreiches Altern: Ein Blick auf die Bevölkerung im Rahmen der KORA-Age-Studie

Author

Peters, A., Döring, A., Ladwig, K.-H., Meisinger, C., Linkohr, B., Autenrieth, C., Baumeister, S.E., Behr, J., Bergner, A., Bickel, H., Bidlingmaier, M., Dias, A., Emeny, R.T., Fischer, B., Grill, E., Gorzelniak, L., Hänsch, H., Heidbreder, S., Heier, M., Horsch, A., Huber, D., Huber, R.M., Jörres, R.A., Kääb, S., Karrasch, S., Kirchberger, I., Klug, G., Kranz, B., Kuch, B., Lacruz, M.E., Lang, O., Mielck, A., Nowak, D., Perz, S., Schneider, A., Schulz, H., Müller, M., Seidl, H., Strobl, R., Thorand, B., Wende, R., Weidenhammer, W., Zimmermann, A.-K., Wichmann, H.-E., and Holle, R.

Published
2011
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26. Free Communications 5: Epidemiology, genetics, outcomes Inflammatory markers and extent and progression of early atherosclerosis: Pooled analysis of individual participant data from 20 prospective studies of the PROG-IMT collaboration: WSC-1521

Author

Willeit, P, Thompson, S G, Agewall, S, Bergström, G, Bickel, H, Catapano, A L, Chien, K L, de Groot, E, Empana, J P, Etgen, T, Franco, O H, Iglseder, B, Johnsen, S H, Kavousi, M, Lind, L, Liu, J, Mathiesen, E B, Norata, G D, Olsen, M H, Papagianni, A, Poppert, H, Price, J F, Sacco, R L, Yanez, D N, Zhao, D, Schminke, U, Bülbül, A, Polak, J F, Sitzer, M, Hofman, A, Grigore, L, Dörr, M, Su, T C, Ducimetière, P, Xie, W, Ronkainen, K, Kiechl, S, Rundek, T, Robertson, C, Fagerberg, B, Bokemark, L, Steinmetz, H, Ikram, M A, Völzke, H, Lin, H J, Plichart, M, Tuomainen, T P, Desvarieux, M, McLachlan, S, Schmidt, C, Kauhanen, J, Willeit, J, Lorenz, M W, and Sander, D

Published
2014

30. Erratum: stematic review and meta-analysis of individual participant data (Clin Epidemiol. 2018, 10, 363–379)

Author

Eurelings L. S. M., van Dalen J. W., Ter Riet G., Moll van Charante E. P., Richard E., van Gool W. A., Almeida O. P., Alexandre T. S., Baune B. T., Bickel H., Cacciatore F., Cooper C., de Craen T. A. J. M., Degryse J. -M., Di Bari M., Duarte Y. A., Feng L., Ferrara N., Flicker L., Gallucci M., Guaita A., Harrison S. L., Katz M. J., Lebrao M. L., Leung J., Lipton R. B., Mengoni M., Ng T. P., Ostbye T., Panza F., Polito L., Sander D., Solfrizzi V., Syddall H. E., van der Mast R. C., Vaes B., Woo J., Yaffe K., Gao S., Ho S. C., Lindsay J., Sham A., Reppermund S., Unverzagt F. W., Eurelings, L. S. M., van Dalen, J. W., Ter Riet, G., Moll van Charante, E. P., Richard, E., van Gool, W. A., Almeida, O. P., Alexandre, T. S., Baune, B. T., Bickel, H., Cacciatore, F., Cooper, C., de Craen, T. A. J. M., Degryse, J. -M., Di Bari, M., Duarte, Y. A., Feng, L., Ferrara, N., Flicker, L., Gallucci, M., Guaita, A., Harrison, S. L., Katz, M. J., Lebrao, M. L., Leung, J., Lipton, R. B., Mengoni, M., Ng, T. P., Ostbye, T., Panza, F., Polito, L., Sander, D., Solfrizzi, V., Syddall, H. E., van der Mast, R. C., Vaes, B., Woo, J., Yaffe, K., Gao, S., Ho, S. C., Lindsay, J., Sham, A., Reppermund, S., and Unverzagt, F. W.

Abstract

Page 363, affiliations section, “On behalf of the ICARA Study Group” should instead read “and the ICARA study group”.

Published
2019

35. Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium

Author

Bahls, M, Lorenz, MW, Dörr, M, Gao, L, Kitagawa, K, Tuomainen, TP, Agewall, S, Berenson, G, Catapano, AL, Norata, GD, Bots, ML, van Gilst, W, Asselbergs, FW, Brouwers, F, Uthoff, H, Sander, D, Poppert, H, Olsen, M H, Empana, JP, Schminke, U, Baldassarre, D, Veglia, F, Franco Duran, OH, Kavousi, Maryam, de Groot, E, Mathiesen, EB, Grigore, L, Polak, JF, Rundek, T, Stehouwer, CDA, Skilton, M, Hatzitolios, AI, Savopoulos, C, Ntaios, G, Plichart, M, McLachlan, S, Lind, L, Willeit, P, Steinmetz, H, Desvarieux, M, Ikram, Arfan, Johnsen, SH, Schmidt, C, Willeit, J, Ducimetiere, P, Price, JF, Bergström, G, Kauhanen, J, Kiechl, S, Sitzer, M, Bickel, H, Sacco, RL, Hofman, Bert, Völzke, H, Thompson, SG, Bahls, M, Lorenz, MW, Dörr, M, Gao, L, Kitagawa, K, Tuomainen, TP, Agewall, S, Berenson, G, Catapano, AL, Norata, GD, Bots, ML, van Gilst, W, Asselbergs, FW, Brouwers, F, Uthoff, H, Sander, D, Poppert, H, Olsen, M H, Empana, JP, Schminke, U, Baldassarre, D, Veglia, F, Franco Duran, OH, Kavousi, Maryam, de Groot, E, Mathiesen, EB, Grigore, L, Polak, JF, Rundek, T, Stehouwer, CDA, Skilton, M, Hatzitolios, AI, Savopoulos, C, Ntaios, G, Plichart, M, McLachlan, S, Lind, L, Willeit, P, Steinmetz, H, Desvarieux, M, Ikram, Arfan, Johnsen, SH, Schmidt, C, Willeit, J, Ducimetiere, P, Price, JF, Bergström, G, Kauhanen, J, Kiechl, S, Sitzer, M, Bickel, H, Sacco, RL, Hofman, Bert, Völzke, H, and Thompson, SG

Published
2020

38. Demenzen

Author

Förstl, H., primary, Bickel, H., additional, Perneczky, R., additional, Hüll, M., additional, and Daffertshofer, M., additional

Published
2011
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41. Net costs of dementia by disease stage

Author

Leicht, H., Heinrich, S., Heider, D., Bachmann, C., Bickel, H., van den Bussche, H., Fuchs, A., Luppa, M., Maier, W., Mösch, E., Pentzek, M., Rieder-Heller, S. G., Tebarth, F., Werle, J., Weyerer, S., Wiese, B., Zimmermann, T., and König, H.-H.

Published
2011
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42. A genome-wide survey of human short-term memory

Author

Papassotiropoulos, A, Henke, K, Stefanova, E, Aerni, A, Müller, A, Demougin, P, Vogler, C, Sigmund, J C, Gschwind, L, Huynh, K-D, Coluccia, D, Mondadori, C R, Hänggi, J, Buchmann, A, Kostic, V, Novakovic, I, van den Bussche, H, Kaduszkiewicz, H, Weyerer, S, Bickel, H, Riedel-Heller, S, Pentzek, M, Wiese, B, Dichgans, M, Wagner, M, Jessen, F, Maier, W, and de Quervain, D J-F

Published
2011
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45. Correction: Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration (PLoS One (2018) 13:4 (e0191172) DOI: 10.1371/journal.pone.0191172)

Author

Lorenz M. W., Gao L., Ziegelbauer K., Norata G. D., Empana J. P., Schmidtmann I., Lin H. -J., McLachlan S., Bokemark L., Ronkainen K., Amato M., Schminke U., Srinivasan S. R., Lind L., Okazaki S., Stehouwer C. D. A., Willeit P., Polak J. F., Steinmetz H., Sander D., Poppert H., Desvarieux M., Arfan Ikram M., Johnsen S. H., Staub D., Sirtori C. R., Iglseder B., Beloqui O., Engstrom G., Friera A., Rozza F., Xie W., Parraga G., Grigore L., Plichart M., Blankenberg S., Su T. -C., Schmidt C., Tuomainen T. -P., Veglia F., Volzke H., Nijpels G., Willeit J., Sacco R. L., Franco O. H., Uthoff H., Hedblad B., Suarez C., Izzo R., Zhao D., Wannarong T., Catapano A., Ducimetiere P., Espinola-Klein C., Chien K. -L., Price J. F., Bergstrom G., Kauhanen J., Tremoli E., Dorr M., Berenson G., Kitagawa K., Dekker J. M., Kiechl S., Sitzer M., Bickel H., Rundek T., Hofman A., Mathiesen E. B., Castelnuovo S., Landecho M. F., Rosvall M., Gabriel R., De Luca N., Liu J., Baldassarre D., Kavousi M., De Groot E., Bots M. L., Yanez D. N., Thompson S. G., Lorenz, M. W., Gao, L., Ziegelbauer, K., Norata, G. D., Empana, J. P., Schmidtmann, I., Lin, H. -J., Mclachlan, S., Bokemark, L., Ronkainen, K., Amato, M., Schminke, U., Srinivasan, S. R., Lind, L., Okazaki, S., Stehouwer, C. D. A., Willeit, P., Polak, J. F., Steinmetz, H., Sander, D., Poppert, H., Desvarieux, M., Arfan Ikram, M., Johnsen, S. H., Staub, D., Sirtori, C. R., Iglseder, B., Beloqui, O., Engstrom, G., Friera, A., Rozza, F., Xie, W., Parraga, G., Grigore, L., Plichart, M., Blankenberg, S., Su, T. -C., Schmidt, C., Tuomainen, T. -P., Veglia, F., Volzke, H., Nijpels, G., Willeit, J., Sacco, R. L., Franco, O. H., Uthoff, H., Hedblad, B., Suarez, C., Izzo, R., Zhao, D., Wannarong, T., Catapano, A., Ducimetiere, P., Espinola-Klein, C., Chien, K. -L., Price, J. F., Bergstrom, G., Kauhanen, J., Tremoli, E., Dorr, M., Berenson, G., Kitagawa, K., Dekker, J. M., Kiechl, S., Sitzer, M., Bickel, H., Rundek, T., Hofman, A., Mathiesen, E. B., Castelnuovo, S., Landecho, M. F., Rosvall, M., Gabriel, R., De Luca, N., Liu, J., Baldassarre, D., Kavousi, M., De Groot, E., Bots, M. L., Yanez, D. N., and Thompson, S. G.

Abstract

An affiliation for Moise Desvarieux is missing. In addition to affiliation #22, Moise Desvarieux is affiliated with: METHODS Core, Centre de Recherche Epidémiologie et Statistique Paris Sorbonne Cité (CRESS), Institut National de la Santé et de la Recherche Médicale (INSERM) UMR 1153, Paris France.

Published
2018

49. Alters- und geschlechtsspezifische Prävalenzen von Angstsymptomen sowie deren Zusammenhang mit Verlusterfahrungen bei Hochaltrigen

Author

Welzel, FD, Stein, J, Pentzek, M, Bickel, H, Weyerer, S, Wiese, B, König, HH, Scherer, M, Maier, W, Wagner, M, and Riedel-Heller, SG

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund: Ängste zählen neben depressiven Beschwerden zu den häufigsten psychischen Beschwerden im Erwachsenenalter. Bisher jedoch fehlen Studien zu Ängsten im hohen Lebensalter, insbesondere für die Altersgruppe hochaltriger Menschen. Fragestellung: Ziel der vorliegenden[zum vollständigen Text gelangen Sie über die oben angegebene URL], 18. Deutscher Kongress für Versorgungsforschung (DKVF)

Published
2019
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50. Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium

Author

Bahls, M. (Martin), Lorenz, M.W. (Matthias W.), Dörr, M. (Marcus), Gao, L. (Lu), Kitagawa, K. (Kazuo), Tuomainen, T.-P. (Tomi-Pekka), Agewall, S. (Stefan), Berenson, G. (Gerald), Catapano, A.L. (Alberico), Norata, G.D. (Giuseppe), Bots, M.L. (Michiel), Gilst, W.H. (Wiek) van, Asselbergs, F.W. (Folkert), Brouwers, F.P. (Frank P), Uthoff, H. (Heiko), Sander, D. (Dirk), Poppert, H. (Holger), Hecht Olsen, M. (Michael), Empana, J.P. (Jean Philippe), Schminke, U. (Ulf), Baldassarre, D. (Damiano), Veglia, F. (Fabrizio), Franco, O.H. (Oscar), Kavousi, M. (Maryam), Groot, E. (Eric) de, Mathiesen, E.B. (Ellisiv), Grigore, L. (Liliana), Polak, J. (Joseph), Rundek, T. (Tatjana), Stehouwer, C.D. (Coen), Skilton, M.R. (Michael R), Hatzitolios, A.I. (Apostolos I), Savopoulos, C. (Christos), Ntaios, G. (George), Plichart, M. (Matthieu), McLachlan, S. (Stela), Kao, W.H.L. (Wen), Willeit, P. (Peter), Steinmetz, H. (Helmuth), Desvarieux, M. (Moise), Ikram, M.A. (Arfan), Johnsen, S.H., Schmidt, C. (Caroline), Willeit, J. (Johann), Ducimetiere, P. (P.), Price, J.F. (Jackie F), Bergström, G. (Göran), Kauhanen, J. (Jussi), Kiechl, S. (Stefan), Sitzer, M. (Matthias), Bickel, H. (Horst), Muir, K.W. (Keith), Hofman, A. (Albert), Völzke, H. (Henry), Thompson, S.G. (Simon G), Bahls, M. (Martin), Lorenz, M.W. (Matthias W.), Dörr, M. (Marcus), Gao, L. (Lu), Kitagawa, K. (Kazuo), Tuomainen, T.-P. (Tomi-Pekka), Agewall, S. (Stefan), Berenson, G. (Gerald), Catapano, A.L. (Alberico), Norata, G.D. (Giuseppe), Bots, M.L. (Michiel), Gilst, W.H. (Wiek) van, Asselbergs, F.W. (Folkert), Brouwers, F.P. (Frank P), Uthoff, H. (Heiko), Sander, D. (Dirk), Poppert, H. (Holger), Hecht Olsen, M. (Michael), Empana, J.P. (Jean Philippe), Schminke, U. (Ulf), Baldassarre, D. (Damiano), Veglia, F. (Fabrizio), Franco, O.H. (Oscar), Kavousi, M. (Maryam), Groot, E. (Eric) de, Mathiesen, E.B. (Ellisiv), Grigore, L. (Liliana), Polak, J. (Joseph), Rundek, T. (Tatjana), Stehouwer, C.D. (Coen), Skilton, M.R. (Michael R), Hatzitolios, A.I. (Apostolos I), Savopoulos, C. (Christos), Ntaios, G. (George), Plichart, M. (Matthieu), McLachlan, S. (Stela), Kao, W.H.L. (Wen), Willeit, P. (Peter), Steinmetz, H. (Helmuth), Desvarieux, M. (Moise), Ikram, M.A. (Arfan), Johnsen, S.H., Schmidt, C. (Caroline), Willeit, J. (Johann), Ducimetiere, P. (P.), Price, J.F. (Jackie F), Bergström, G. (Göran), Kauhanen, J. (Jussi), Kiechl, S. (Stefan), Sitzer, M. (Matthias), Bickel, H. (Horst), Muir, K.W. (Keith), Hofman, A. (Albert), Völzke, H. (Henry), and Thompson, S.G. (Simon G)

Abstract

Aims: Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear. Methods and results: An individual participant meta-analysis was used to associate the annualised progression of systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol with future cardiovascular disease risk in 13 prospective cohort studies of the PROG-IMT collaboration (n = 34,072). Follow-up data included information on a combined cardiovascular disease endpoint of myocardial infarction, stroke, or vascular death. In secondary analyses, annualised progression was replaced with average. Log hazard ratios per standard deviation difference were pooled across studies by a random effects meta-analysis. In primary analysis, the annualised progression of total cholesterol was marginally related to a higher cardiovascular disease risk (hazard ratio (HR) 1.04, 95% confidence interval (CI) 1.00 to 1.07). The annualised progression of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol was not associated with future cardiovascular disease risk. In secondary analysis, average systolic blood pressure (HR 1.20 95% CI 1.11 to 1.29) and low-density lipoprotein cholesterol (HR 1.09, 95% CI 1.02 to 1.16) were related to a greater, while high-density lipoprotein cholesterol (HR 0.92, 95% CI 0.88 to 0.97) was related to a lower risk of future cardiovascular disease events. Conclusion: Averaged measurements of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol displayed significant linear relationships with the risk of future cardiovascular disease events. However, there was no clear association between the annualised progression of these conventional risk factors in

Published
2019
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