781 results on '"Bickeböller, Heike"'
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2. Das Zertifikat „Epidemiologie' der Fachgesellschaften DGEpi, GMDS, DGSMP und IBS-DR: Aktualisierung 2012 [The certificate 'epidemiology' of the scientific societies DGEpi, GMDS, DGSMP and IBS-DR: Update 2012]
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Zeeb, Hajo, Bickeböller, Heike, Jöckel, Karl-Heinz, Stang, Andreas, Stark, Klaus, Steindorf, Karen, Swart, Enno, and Waldmann, Annika
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epidemiology ,education ,certificate ,scientific societies ,Epidemiologie ,Weiterbildung ,Zertifikat ,Fachgesellschaften ,Computer applications to medicine. Medical informatics ,R858-859.7 ,Infectious and parasitic diseases ,RC109-216 - Abstract
[english] The certificate “epidemiology” provides an opportunity for epidemiologists in Germany to have their postgraduate further education in epidemiology certified by the scientific societies. The original certificate guidelines from 1992 have now been revised to reflect changes and current development. This paper documents the revision process and the current version of the guidelines.[german] Das Zertifikat Epidemiologie bietet für Epidemiologinnen und Epidemiologen in Deutschland die Möglichkeit, ihre epidemiologische Weiterbildung durch die Fachgesellschaften zertifizieren zu lassen. Die seit 1992 unveränderten Richtlinien zur Erlangung des Zertifikats wurden in den vergangenen Jahren überarbeitet und aktualisiert. Das Paper dokumentiert den Prozess der Überarbeitung und die jetzt geltenden Richtlinien
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- 2013
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3. Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer.
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Byun, Jinyoung, Han, Younghun, Li, Yafang, Xia, Jun, Long, Erping, Choi, Jiyeon, Xiao, Xiangjun, Zhu, Meng, Zhou, Wen, Sun, Ryan, Bossé, Yohan, Song, Zhuoyi, Schwartz, Ann, Lusk, Christine, Rafnar, Thorunn, Stefansson, Kari, Zhang, Tongwu, Zhao, Wei, Pettit, Rowland W, Liu, Yanhong, Li, Xihao, Zhou, Hufeng, Walsh, Kyle M, Gorlov, Ivan, Gorlova, Olga, Zhu, Dakai, Rosenberg, Susan M, Pinney, Susan, Bailey-Wilson, Joan E, Mandal, Diptasri, de Andrade, Mariza, Gaba, Colette, Willey, James C, You, Ming, Anderson, Marshall, Wiencke, John K, Albanes, Demetrius, Lam, Stephan, Tardon, Adonina, Chen, Chu, Goodman, Gary, Bojeson, Stig, Brenner, Hermann, Landi, Maria Teresa, Chanock, Stephen J, Johansson, Mattias, Muley, Thomas, Risch, Angela, Wichmann, H-Erich, Bickeböller, Heike, Christiani, David C, Rennert, Gad, Arnold, Susanne, Field, John K, Shete, Sanjay, Le Marchand, Loic, Melander, Olle, Brunnstrom, Hans, Liu, Geoffrey, Andrew, Angeline S, Kiemeney, Lambertus A, Shen, Hongbing, Zienolddiny, Shanbeh, Grankvist, Kjell, Johansson, Mikael, Caporaso, Neil, Cox, Angela, Hong, Yun-Chul, Yuan, Jian-Min, Lazarus, Philip, Schabath, Matthew B, Aldrich, Melinda C, Patel, Alpa, Lan, Qing, Rothman, Nathaniel, Taylor, Fiona, Kachuri, Linda, Witte, John S, Sakoda, Lori C, Spitz, Margaret, Brennan, Paul, Lin, Xihong, McKay, James, Hung, Rayjean J, and Amos, Christopher I
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Humans ,Lung Neoplasms ,Genetic Predisposition to Disease ,RNA-Binding Proteins ,DNA-Binding Proteins ,Polymorphism ,Single Nucleotide ,Quantitative Trait Loci ,Genome-Wide Association Study ,Human Genome ,Cancer ,Genetics ,Lung ,2.1 Biological and endogenous factors ,Aetiology ,Biological Sciences ,Medical and Health Sciences ,Developmental Biology - Abstract
To identify new susceptibility loci to lung cancer among diverse populations, we performed cross-ancestry genome-wide association studies in European, East Asian and African populations and discovered five loci that have not been previously reported. We replicated 26 signals and identified 10 new lead associations from previously reported loci. Rare-variant associations tended to be specific to populations, but even common-variant associations influencing smoking behavior, such as those with CHRNA5 and CYP2A6, showed population specificity. Fine-mapping and expression quantitative trait locus colocalization nominated several candidate variants and susceptibility genes such as IRF4 and FUBP1. DNA damage assays of prioritized genes in lung fibroblasts indicated that a subset of these genes, including the pleiotropic gene IRF4, potentially exert effects by promoting endogenous DNA damage.
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- 2022
4. Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population
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Shi, Jianxin, Shiraishi, Kouya, Choi, Jiyeon, Matsuo, Keitaro, Chen, Tzu-Yu, Dai, Juncheng, Hung, Rayjean J., Chen, Kexin, Shu, Xiao-Ou, Kim, Young Tae, Landi, Maria Teresa, Lin, Dongxin, Zheng, Wei, Yin, Zhihua, Zhou, Baosen, Song, Bao, Wang, Jiucun, Seow, Wei Jie, Song, Lei, Chang, I-Shou, Hu, Wei, Chien, Li-Hsin, Cai, Qiuyin, Hong, Yun-Chul, Kim, Hee Nam, Wu, Yi-Long, Wong, Maria Pik, Richardson, Brian Douglas, Funderburk, Karen M., Li, Shilan, Zhang, Tongwu, Breeze, Charles, Wang, Zhaoming, Blechter, Batel, Bassig, Bryan A., Kim, Jin Hee, Albanes, Demetrius, Wong, Jason Y. Y., Shin, Min-Ho, Chung, Lap Ping, Yang, Yang, An, She-Juan, Zheng, Hong, Yatabe, Yasushi, Zhang, Xu-Chao, Kim, Young-Chul, Caporaso, Neil E., Chang, Jiang, Ho, James Chung Man, Kubo, Michiaki, Daigo, Yataro, Song, Minsun, Momozawa, Yukihide, Kamatani, Yoichiro, Kobayashi, Masashi, Okubo, Kenichi, Honda, Takayuki, Hosgood, Dean H., Kunitoh, Hideo, Patel, Harsh, Watanabe, Shun-ichi, Miyagi, Yohei, Nakayama, Haruhiko, Matsumoto, Shingo, Horinouchi, Hidehito, Tsuboi, Masahiro, Hamamoto, Ryuji, Goto, Koichi, Ohe, Yuichiro, Takahashi, Atsushi, Goto, Akiteru, Minamiya, Yoshihiro, Hara, Megumi, Nishida, Yuichiro, Takeuchi, Kenji, Wakai, Kenji, Matsuda, Koichi, Murakami, Yoshinori, Shimizu, Kimihiro, Suzuki, Hiroyuki, Saito, Motonobu, Ohtaki, Yoichi, Tanaka, Kazumi, Wu, Tangchun, Wei, Fusheng, Dai, Hongji, Machiela, Mitchell J., Su, Jian, Kim, Yeul Hong, Oh, In-Jae, Lee, Victor Ho Fun, Chang, Gee-Chen, Tsai, Ying-Huang, Chen, Kuan-Yu, Huang, Ming-Shyan, Su, Wu-Chou, Chen, Yuh-Min, Seow, Adeline, Park, Jae Yong, Kweon, Sun-Seog, Chen, Kun-Chieh, Gao, Yu-Tang, Qian, Biyun, Wu, Chen, Lu, Daru, Liu, Jianjun, Schwartz, Ann G., Houlston, Richard, Spitz, Margaret R., Gorlov, Ivan P., Wu, Xifeng, Yang, Ping, Lam, Stephen, Tardon, Adonina, Chen, Chu, Bojesen, Stig E., Johansson, Mattias, Risch, Angela, Bickeböller, Heike, Ji, Bu-Tian, Wichmann, H-Erich, Christiani, David C., Rennert, Gadi, Arnold, Susanne, Brennan, Paul, McKay, James, Field, John K., Shete, Sanjay S., Le Marchand, Loic, Liu, Geoffrey, Andrew, Angeline, Kiemeney, Lambertus A., Zienolddiny-Narui, Shan, Grankvist, Kjell, Johansson, Mikael, Cox, Angela, Taylor, Fiona, Yuan, Jian-Min, Lazarus, Philip, Schabath, Matthew B., Aldrich, Melinda C., Jeon, Hyo-Sung, Jiang, Shih Sheng, Sung, Jae Sook, Chen, Chung-Hsing, Hsiao, Chin-Fu, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Burdett, Laurie, Yeager, Meredith, Hutchinson, Amy, Hicks, Belynda, Liu, Jia, Zhu, Bin, Berndt, Sonja I., Wu, Wei, Wang, Junwen, Li, Yuqing, Choi, Jin Eun, Park, Kyong Hwa, Sung, Sook Whan, Liu, Li, Kang, Chang Hyun, Wang, Wen-Chang, Xu, Jun, Guan, Peng, Tan, Wen, Yu, Chong-Jen, Yang, Gong, Sihoe, Alan Dart Loon, Chen, Ying, Choi, Yi Young, Kim, Jun Suk, Yoon, Ho-Il, Park, In Kyu, Xu, Ping, He, Qincheng, Wang, Chih-Liang, Hung, Hsiao-Han, Vermeulen, Roel C. H., Cheng, Iona, Wu, Junjie, Lim, Wei-Yen, Tsai, Fang-Yu, Chan, John K. C., Li, Jihua, Chen, Hongyan, Lin, Hsien-Chih, Jin, Li, Liu, Jie, Sawada, Norie, Yamaji, Taiki, Wyatt, Kathleen, Li, Shengchao A., Ma, Hongxia, Zhu, Meng, Wang, Zhehai, Cheng, Sensen, Li, Xuelian, Ren, Yangwu, Chao, Ann, Iwasaki, Motoki, Zhu, Junjie, Jiang, Gening, Fei, Ke, Wu, Guoping, Chen, Chih-Yi, Chen, Chien-Jen, Yang, Pan-Chyr, Yu, Jinming, Stevens, Victoria L., Fraumeni, Jr, Joseph F., Chatterjee, Nilanjan, Gorlova, Olga Y., Hsiung, Chao Agnes, Amos, Christopher I., Shen, Hongbing, Chanock, Stephen J., Rothman, Nathaniel, Kohno, Takashi, and Lan, Qing
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- 2023
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5. Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis
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Landi, Maria Teresa, Stevens, Victoria, Wang, Ying, Albanes, Demetrios, Caporaso, Neil, Brennan, Paul, Amos, Christopher I., Shete, Sanjay, Hung, Rayjean J., Bickeböller, Heike, Risch, Angela, Houlston, Richard, Lam, Stephen, Tardon, Adonina, Chen, Chu, Bojesen, Stig E., Johansson, Mattias, Wichmann, H-Erich, Christiani, David, Rennert, Gadi, Arnold, Susanne, Field, John K., Le Marchand, Loic, Melander, Olle, Brunnström, Hans, Liu, Geoffrey, Andrew, Angeline, Kiemeney, Lambertus A., Shen, Hongbing, Zienolddiny, Shan, Grankvist, Kjell, Johansson, Mikael, Teare, M. Dawn, Hong, Yun-Chul, Yuan, Jian-Min, Lazarus, Philip, Schabath, Matthew B., Aldrich, Melinda C., Eeles, Rosalind A., Haiman, Christopher A., Kote-Jarai, Zsofia, Schumacher, Fredrick R., Benlloch, Sara, Al Olama, Ali Amin, Muir, Kenneth R., Berndt, Sonja I., Conti, David V., Wiklund, Fredrik, Chanock, Stephen, Tangen, Catherine M., Batra, Jyotsna, Clements, Judith A., Grönberg, Henrik, Pashayan, Nora, Schleutker, Johanna, Albanes, Demetrius, Weinstein, Stephanie J., Wolk, Alicja, West, Catharine M.L., Mucci, Lorelei A., Cancel-Tassin, Géraldine, Koutros, Stella, Sørensen, Karina Dalsgaard, Grindedal, Eli Marie, Neal, David E., Hamdy, Freddie C., Donovan, Jenny L., Travis, Ruth C., Hamilton, Robert J., Ingles, Sue Ann, Rosenstein, Barry S., Lu, Yong-Jie, Giles, Graham G., MacInnis, Robert J., Kibel, Adam S., Vega, Ana, Kogevinas, Manolis, Penney, Kathryn L., Park, Jong Y., Stanfrod, Janet L., Cybulski, Cezary, Nordestgaard, Børge G., Nielsen, Sune F., Brenner, Hermann, Maier, Christiane, Logothetis, Christopher J., John, Esther M., Teixeira, Manuel R., Neuhausen, Susan L., De Ruyck, Kim, Razack, Azad, Newcomb, Lisa F., Lessel, Davor, Kaneva, Radka, Usmani, Nawaid, Claessens, Frank, Townsend, Paul A., Castelao, Jose Esteban, Roobol, Monique J., Menegaux, Florence, Khaw, Kay-Tee, Cannon-Albright, Lisa, Pandha, Hardev, Thibodeau, Stephen N., Hunter, David J., Kraft, Peter, Blot, William J., Riboli, Elio, Yarmolinsky, James, Robinson, Jamie W., Mariosa, Daniela, Karhunen, Ville, Huang, Jian, Dimou, Niki, Murphy, Neil, Burrows, Kimberley, Bouras, Emmanouil, Smith-Byrne, Karl, Lewis, Sarah J., Galesloot, Tessel E., Vermeulen, Sita, Martin, Paul, Hou, Lifang, Newcomb, Polly A., White, Emily, Wu, Anna H., Le Marchand, Loïc, Phipps, Amanda I., Buchanan, Daniel D., Zhao, Sizheng Steven, Gill, Dipender, Chanock, Stephen J., Purdue, Mark P., Davey Smith, George, Herzig, Karl-Heinz, Järvelin, Marjo-Riitta, Amos, Chris I., Dehghan, Abbas, Gunter, Marc J., Tsilidis, Kostas K., and Martin, Richard M.
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- 2024
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6. Mosaic Chromosomal Alterations Are Associated With Increased Lung Cancer Risk: Insight From the INTEGRAL-ILCCO Cohort Analysis
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Cheng, Chao, Hong, Wei, Li, Yafang, Xiao, Xiangjun, McKay, James, Han, Younghun, Byun, Jinyoung, Peng, Bo, Albanes, Demetrios, Lam, Stephen, Tardon, Adonina, Chen, Chu, Bojesen, Stig E., Landi, Maria T., Johansson, Mattias, Risch, Angela, Bickeböller, Heike, Wichmann, H-Erich, Christiani, David C., Rennert, Gad, Arnold, Susanne, Goodman, Gary, Field, John K., Davies, Michael P.A., Shete, Sanjay S., Le Marchand, Loic, Liu, Geoffrey, Hung, Rayjean J., Andrew, Angeline S., Kiemeney, Lambertus A., Zhu, Meng, Shen, Hongbing, Zienolddiny, Shan, Grankvist, Kjell, Johansson, Mikael, Cox, Angela, Hong, Yun-Chul, Yuan, Jian-Min, Lazarus, Philip, Schabath, Matthew B., Aldrich, Melinda C., Brennan, Paul, Li, Yong, Gorlova, Olga, Gorlov, Ivan, and Amos, Christopher I.
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- 2023
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7. Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility.
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Kachuri, Linda, Johansson, Mattias, Rashkin, Sara R, Graff, Rebecca E, Bossé, Yohan, Manem, Venkata, Caporaso, Neil E, Landi, Maria Teresa, Christiani, David C, Vineis, Paolo, Liu, Geoffrey, Scelo, Ghislaine, Zaridze, David, Shete, Sanjay S, Albanes, Demetrius, Aldrich, Melinda C, Tardón, Adonina, Rennert, Gad, Chen, Chu, Goodman, Gary E, Doherty, Jennifer A, Bickeböller, Heike, Field, John K, Davies, Michael P, Dawn Teare, M, Kiemeney, Lambertus A, Bojesen, Stig E, Haugen, Aage, Zienolddiny, Shanbeh, Lam, Stephen, Le Marchand, Loïc, Cheng, Iona, Schabath, Matthew B, Duell, Eric J, Andrew, Angeline S, Manjer, Jonas, Lazarus, Philip, Arnold, Susanne, McKay, James D, Emami, Nima C, Warkentin, Matthew T, Brhane, Yonathan, Obeidat, Ma'en, Martin, Richard M, Relton, Caroline, Davey Smith, George, Haycock, Philip C, Amos, Christopher I, Brennan, Paul, Witte, John S, and Hung, Rayjean J
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Lung ,Humans ,Lung Neoplasms ,Genetic Predisposition to Disease ,Respiratory Function Tests ,Vital Capacity ,Forced Expiratory Volume ,Prospective Studies ,Phenotype ,Polymorphism ,Single Nucleotide ,Adult ,Aged ,Middle Aged ,Female ,Male ,Mendelian Randomization Analysis ,Polymorphism ,Single Nucleotide - Abstract
Impaired lung function is often caused by cigarette smoking, making it challenging to disentangle its role in lung cancer susceptibility. Investigation of the shared genetic basis of these phenotypes in the UK Biobank and International Lung Cancer Consortium (29,266 cases, 56,450 controls) shows that lung cancer is genetically correlated with reduced forced expiratory volume in one second (FEV1: rg = 0.098, p = 2.3 × 10-8) and the ratio of FEV1 to forced vital capacity (FEV1/FVC: rg = 0.137, p = 2.0 × 10-12). Mendelian randomization analyses demonstrate that reduced FEV1 increases squamous cell carcinoma risk (odds ratio (OR) = 1.51, 95% confidence intervals: 1.21-1.88), while reduced FEV1/FVC increases the risk of adenocarcinoma (OR = 1.17, 1.01-1.35) and lung cancer in never smokers (OR = 1.56, 1.05-2.30). These findings support a causal role of pulmonary impairment in lung cancer etiology. Integrative analyses reveal that pulmonary function instruments, including 73 novel variants, influence lung tissue gene expression and implicate immune-related pathways in mediating the observed effects on lung carcinogenesis.
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- 2020
8. Genetisch-molekulare Grundlagen von Gesundheit und Krankheit
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Bickeböller, Heike and Haring, Robin, editor
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- 2022
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9. Publisher Correction: Shared heritability and functional enrichment across six solid cancers.
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Jiang, Xia, Finucane, Hilary K, Schumacher, Fredrick R, Schmit, Stephanie L, Tyrer, Jonathan P, Han, Younghun, Michailidou, Kyriaki, Lesseur, Corina, Kuchenbaecker, Karoline B, Dennis, Joe, Conti, David V, Casey, Graham, Gaudet, Mia M, Huyghe, Jeroen R, Albanes, Demetrius, Aldrich, Melinda C, Andrew, Angeline S, Andrulis, Irene L, Anton-Culver, Hoda, Antoniou, Antonis C, Antonenkova, Natalia N, Arnold, Susanne M, Aronson, Kristan J, Arun, Banu K, Bandera, Elisa V, Barkardottir, Rosa B, Barnes, Daniel R, Batra, Jyotsna, Beckmann, Matthias W, Benitez, Javier, Benlloch, Sara, Berchuck, Andrew, Berndt, Sonja I, Bickeböller, Heike, Bien, Stephanie A, Blomqvist, Carl, Boccia, Stefania, Bogdanova, Natalia V, Bojesen, Stig E, Bolla, Manjeet K, Brauch, Hiltrud, Brenner, Hermann, Brenton, James D, Brook, Mark N, Brunet, Joan, Brunnström, Hans, Buchanan, Daniel D, Burwinkel, Barbara, Butzow, Ralf, Cadoni, Gabriella, Caldés, Trinidad, Caligo, Maria A, Campbell, Ian, Campbell, Peter T, Cancel-Tassin, Géraldine, Cannon-Albright, Lisa, Campa, Daniele, Caporaso, Neil, Carvalho, André L, Chan, Andrew T, Chang-Claude, Jenny, Chanock, Stephen J, Chen, Chu, Christiani, David C, Claes, Kathleen BM, Claessens, Frank, Clements, Judith, Collée, J Margriet, Correa, Marcia Cruz, Couch, Fergus J, Cox, Angela, Cunningham, Julie M, Cybulski, Cezary, Czene, Kamila, Daly, Mary B, deFazio, Anna, Devilee, Peter, Diez, Orland, Gago-Dominguez, Manuela, Donovan, Jenny L, Dörk, Thilo, Duell, Eric J, Dunning, Alison M, Dwek, Miriam, Eccles, Diana M, Edlund, Christopher K, Edwards, Digna R Velez, Ellberg, Carolina, Evans, D Gareth, Fasching, Peter A, Ferris, Robert L, Liloglou, Triantafillos, Figueiredo, Jane C, Fletcher, Olivia, Fortner, Renée T, Fostira, Florentia, Franceschi, Silvia, Friedman, Eitan, Gallinger, Steven J, and Ganz, Patricia A
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MD Multidisciplinary - Abstract
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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- 2019
10. Lung Cancer Risk in Never-Smokers of European Descent is Associated With Genetic Variation in the 5p15.33 TERT-CLPTM1Ll Region
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Hung, Rayjean J, Spitz, Margaret R, Houlston, Richard S, Schwartz, Ann G, Field, John K, Ying, Jun, Li, Yafang, Han, Younghun, Ji, Xuemei, Chen, Wei, Wu, Xifeng, Gorlov, Ivan P, Na, Jie, de Andrade, Mariza, Liu, Geoffrey, Brhane, Yonathan, Diao, Nancy, Wenzlaff, Angela, Davies, Michael PA, Liloglou, Triantafillos, Timofeeva, Maria, Muley, Thomas, Rennert, Hedy, Saliba, Walid, Ryan, Bríd M, Bowman, Elise, Barros-Dios, Juan-Miguel, Pérez-Ríos, Mónica, Morgenstern, Hal, Zienolddiny, Shanbeh, Skaug, Vidar, Ugolini, Donatella, Bonassi, Stefano, van der Heijden, Erik HFM, Tardon, Adonina, Bojesen, Stig E, Landi, Maria Teresa, Johansson, Mattias, Bickeböller, Heike, Arnold, Susanne, Le Marchand, Loic, Melander, Olle, Andrew, Angeline, Grankvist, Kjell, Caporaso, Neil, Teare, M Dawn, Schabath, Matthew B, Aldrich, Melinda C, Kiemeney, Lambertus A, Wichmann, H-Erich, Lazarus, Philip, Mayordomo, Jose, Neri, Monica, Haugen, Aage, Zhang, Zuo-Feng, Ruano-Raviña, Alberto, Brenner, Hermann, Harris, Curtis C, Orlow, Irene, Rennert, Gadi, Risch, Angela, Brennan, Paul, Christiani, David C, Amos, Christopher I, Yang, Ping, and Gorlova, Olga Y
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Human Genome ,Lung Cancer ,Tobacco ,Prevention ,Cancer ,Genetics ,Clinical Research ,Tobacco Smoke and Health ,Lung ,2.1 Biological and endogenous factors ,Aetiology ,Good Health and Well Being ,Case-Control Studies ,Chromosomes ,Human ,Pair 5 ,Europe ,Female ,Genetic Predisposition to Disease ,Genetic Variation ,Genome-Wide Association Study ,Genotyping Techniques ,Humans ,Lung Neoplasms ,Membrane Proteins ,Middle Aged ,Polymorphism ,Single Nucleotide ,Risk Factors ,Telomerase ,Lung cancer ,Never smokers ,Genome-wide association study ,Genetic susceptibility ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Oncology & Carcinogenesis ,Clinical sciences ,Oncology and carcinogenesis - Abstract
IntroductionInherited susceptibility to lung cancer risk in never-smokers is poorly understood. The major reason for this gap in knowledge is that this disease is relatively uncommon (except in Asians), making it difficult to assemble an adequate study sample. In this study we conducted a genome-wide association study on the largest, to date, set of European-descent never-smokers with lung cancer.MethodsWe conducted a two-phase (discovery and replication) genome-wide association study in never-smokers of European descent. We further augmented the sample by performing a meta-analysis with never-smokers from the recent OncoArray study, which resulted in a total of 3636 cases and 6295 controls. We also compare our findings with those in smokers with lung cancer.ResultsWe detected three genome-wide statistically significant single nucleotide polymorphisms rs31490 (odds ratio [OR]: 0.769, 95% confidence interval [CI]: 0.722-0.820; p value 5.31 × 10-16), rs380286 (OR: 0.770, 95% CI: 0.723-0.820; p value 4.32 × 10-16), and rs4975616 (OR: 0.778, 95% CI: 0.730-0.829; p value 1.04 × 10-14). All three mapped to Chromosome 5 CLPTM1L-TERT region, previously shown to be associated with lung cancer risk in smokers and in never-smoker Asian women, and risk of other cancers including breast, ovarian, colorectal, and prostate.ConclusionsWe found that genetic susceptibility to lung cancer in never-smokers is associated to genetic variants with pan-cancer risk effects. The comparison with smokers shows that top variants previously shown to be associated with lung cancer risk only confer risk in the presence of tobacco exposure, underscoring the importance of gene-environment interactions in the etiology of this disease.
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- 2019
11. Shared heritability and functional enrichment across six solid cancers.
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Jiang, Xia, Finucane, Hilary K, Schumacher, Fredrick R, Schmit, Stephanie L, Tyrer, Jonathan P, Han, Younghun, Michailidou, Kyriaki, Lesseur, Corina, Kuchenbaecker, Karoline B, Dennis, Joe, Conti, David V, Casey, Graham, Gaudet, Mia M, Huyghe, Jeroen R, Albanes, Demetrius, Aldrich, Melinda C, Andrew, Angeline S, Andrulis, Irene L, Anton-Culver, Hoda, Antoniou, Antonis C, Antonenkova, Natalia N, Arnold, Susanne M, Aronson, Kristan J, Arun, Banu K, Bandera, Elisa V, Barkardottir, Rosa B, Barnes, Daniel R, Batra, Jyotsna, Beckmann, Matthias W, Benitez, Javier, Benlloch, Sara, Berchuck, Andrew, Berndt, Sonja I, Bickeböller, Heike, Bien, Stephanie A, Blomqvist, Carl, Boccia, Stefania, Bogdanova, Natalia V, Bojesen, Stig E, Bolla, Manjeet K, Brauch, Hiltrud, Brenner, Hermann, Brenton, James D, Brook, Mark N, Brunet, Joan, Brunnström, Hans, Buchanan, Daniel D, Burwinkel, Barbara, Butzow, Ralf, Cadoni, Gabriella, Caldés, Trinidad, Caligo, Maria A, Campbell, Ian, Campbell, Peter T, Cancel-Tassin, Géraldine, Cannon-Albright, Lisa, Campa, Daniele, Caporaso, Neil, Carvalho, André L, Chan, Andrew T, Chang-Claude, Jenny, Chanock, Stephen J, Chen, Chu, Christiani, David C, Claes, Kathleen BM, Claessens, Frank, Clements, Judith, Collée, J Margriet, Correa, Marcia Cruz, Couch, Fergus J, Cox, Angela, Cunningham, Julie M, Cybulski, Cezary, Czene, Kamila, Daly, Mary B, deFazio, Anna, Devilee, Peter, Diez, Orland, Gago-Dominguez, Manuela, Donovan, Jenny L, Dörk, Thilo, Duell, Eric J, Dunning, Alison M, Dwek, Miriam, Eccles, Diana M, Edlund, Christopher K, Edwards, Digna R Velez, Ellberg, Carolina, Evans, D Gareth, Fasching, Peter A, Ferris, Robert L, Liloglou, Triantafillos, Figueiredo, Jane C, Fletcher, Olivia, Fortner, Renée T, Fostira, Florentia, Franceschi, Silvia, Friedman, Eitan, Gallinger, Steven J, and Ganz, Patricia A
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Humans ,Breast Neoplasms ,Colorectal Neoplasms ,Ovarian Neoplasms ,Head and Neck Neoplasms ,Lung Neoplasms ,Prostatic Neoplasms ,Genetic Predisposition to Disease ,Neoplasm Proteins ,Case-Control Studies ,Smoking ,Mental Disorders ,Inheritance Patterns ,Phenotype ,Polymorphism ,Single Nucleotide ,European Continental Ancestry Group ,Female ,Male ,Genome-Wide Association Study ,Polymorphism ,Single Nucleotide ,Prevention ,Cancer ,Breast Cancer ,Genetics ,Rare Diseases ,Lung Cancer ,Human Genome ,Colo-Rectal Cancer ,Digestive Diseases ,Lung ,MD Multidisciplinary - Abstract
Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10-8), breast and ovarian cancer (rg = 0.24, p = 7 × 10-5), breast and lung cancer (rg = 0.18, p =1.5 × 10-6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.
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- 2019
12. Gene–gene interaction of AhRwith and within the Wntcascade affects susceptibility to lung cancer
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Rosenberger, Albert, Muttray, Nils, Hung, Rayjean J., Christiani, David C., Caporaso, Neil E., Liu, Geoffrey, Bojesen, Stig E., Le Marchand, Loic, Albanes, Demetrios, Aldrich, Melinda C., Tardon, Adonina, Fernández-Tardón, Guillermo, Rennert, Gad, Field, John K., Davies, Michael P. A., Liloglou, Triantafillos, Kiemeney, Lambertus A., Lazarus, Philip, Wendel, Bernadette, Haugen, Aage, Zienolddiny, Shanbeh, Lam, Stephen, Schabath, Matthew B., Andrew, Angeline S., Duell, Eric J., Arnold, Susanne M., Goodman, Gary E., Chen, Chu, Doherty, Jennifer A., Taylor, Fiona, Cox, Angela, Woll, Penella J., Risch, Angela, Muley, Thomas R., Johansson, Mikael, Brennan, Paul, Landi, Maria Teresa, Shete, Sanjay S., Amos, Christopher I., and Bickeböller, Heike
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- 2022
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13. ImputAccur: fast and user-friendly calculation of genotype-imputation accuracy-measures
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Thormann, Kolja A., Tozzi, Viola, Starke, Paula, Bickeböller, Heike, Baum, Marcus, and Rosenberger, Albert
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- 2022
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14. Iam hiQ—a novel pair of accuracy indices for imputed genotypes
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Rosenberger, Albert, Tozzi, Viola, and Bickeböller, Heike
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- 2022
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15. Detecting responses to treatment with fenofibrate in pedigrees.
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Cherlin, Svetlana, Wang, Maggie Haitian, Bickeböller, Heike, and Cantor, Rita M
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Humans ,Hypertriglyceridemia ,Triglycerides ,Drug Administration Schedule ,Linear Models ,DNA Methylation ,CpG Islands ,Polymorphism ,Single Nucleotide ,Quantitative Trait Loci ,Genome-Wide Association Study ,Hypolipidemic Agents ,Fenofibrate ,Epigenomics ,Neural Networks ,Computer ,Epigenetics ,Fenofibrate treatment ,GOLDN study ,Predictive modeling ,Polymorphism ,Single Nucleotide ,Neural Networks ,Computer ,Genetics & Heredity ,Genetics - Abstract
BackgroundFenofibrate (Fb) is a known treatment for elevated triglyceride (TG) levels. The Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study was designed to investigate potential contributors to the effects of Fb on TG levels. Here, we summarize the analyses of 8 papers whose authors had access to the GOLDN data and were grouped together because they pursued investigations into Fb treatment responses as part of GAW20. These papers report explorations of a variety of genetics, epigenetics, and study design questions. Data regarding treatment with 160 mg of micronized Fb per day for 3 weeks included pretreatment and posttreatment TG and methylation levels (ML) at approximately 450,000 epigenetic markers (cytosine-phosphate-guanine [CpG] sites). In addition, approximately 1 million single-nucleotide polymorphisms (SNPs) were genotyped or imputed in each of the study participants, drawn from 188 pedigrees.ResultsThe analyses of a variety of subsets of the GOLDN data used a number of analytic approaches such as linear mixed models, a kernel score test, penalized regression, and artificial neural networks.ConclusionsResults indicate that (a) CpG ML are responsive to Fb; (b) CpG ML should be included in models predicting the TG level responses to Fb;
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- 2018
16. Supplementary Table S6 from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies
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Li, Yafang, primary, Xiao, Xiangjun, primary, Li, Jianrong, primary, Han, Younghun, primary, Cheng, Chao, primary, Fernandes, Gail F., primary, Slewitzke, Shannon E., primary, Rosenberg, Susan M., primary, Zhu, Meng, primary, Byun, Jinyoung, primary, Bossé, Yohan, primary, McKay, James D., primary, Albanes, Demetrios, primary, Lam, Stephen, primary, Tardon, Adonina, primary, Chen, Chu, primary, Bojesen, Stig E., primary, Landi, Maria T., primary, Johansson, Mattias, primary, Risch, Angela, primary, Bickeböller, Heike, primary, Wichmann, H-Erich, primary, Christiani, David C., primary, Rennert, Gad, primary, Arnold, Susanne M., primary, Goodman, Gary E., primary, Field, John K., primary, Davies, Michael P.A., primary, Shete, Sanjay, primary, Marchand, Loïc Le, primary, Liu, Geoffrey, primary, Hung, Rayjean J., primary, Andrew, Angeline S., primary, Kiemeney, Lambertus A., primary, Sun, Ryan, primary, Zienolddiny, Shanbeh, primary, Grankvist, Kjell, primary, Johansson, Mikael, primary, Caporaso, Neil E., primary, Cox, Angela, primary, Hong, Yun-Chul, primary, Lazarus, Philip, primary, Schabath, Matthew B., primary, Aldrich, Melinda C., primary, Schwartz, Ann G., primary, Gorlov, Ivan, primary, Purrington, Kristen S., primary, Yang, Ping, primary, Liu, Yanhong, primary, Bailey-Wilson, Joan E., primary, Pinney, Susan M., primary, Mandal, Diptasri, primary, Willey, James C., primary, Gaba, Colette, primary, Brennan, Paul, primary, Xia, Jun, primary, Shen, Hongbing, primary, and Amos, Christopher I., primary
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- 2024
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17. Data from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies
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Li, Yafang, primary, Xiao, Xiangjun, primary, Li, Jianrong, primary, Han, Younghun, primary, Cheng, Chao, primary, Fernandes, Gail F., primary, Slewitzke, Shannon E., primary, Rosenberg, Susan M., primary, Zhu, Meng, primary, Byun, Jinyoung, primary, Bossé, Yohan, primary, McKay, James D., primary, Albanes, Demetrios, primary, Lam, Stephen, primary, Tardon, Adonina, primary, Chen, Chu, primary, Bojesen, Stig E., primary, Landi, Maria T., primary, Johansson, Mattias, primary, Risch, Angela, primary, Bickeböller, Heike, primary, Wichmann, H-Erich, primary, Christiani, David C., primary, Rennert, Gad, primary, Arnold, Susanne M., primary, Goodman, Gary E., primary, Field, John K., primary, Davies, Michael P.A., primary, Shete, Sanjay, primary, Marchand, Loïc Le, primary, Liu, Geoffrey, primary, Hung, Rayjean J., primary, Andrew, Angeline S., primary, Kiemeney, Lambertus A., primary, Sun, Ryan, primary, Zienolddiny, Shanbeh, primary, Grankvist, Kjell, primary, Johansson, Mikael, primary, Caporaso, Neil E., primary, Cox, Angela, primary, Hong, Yun-Chul, primary, Lazarus, Philip, primary, Schabath, Matthew B., primary, Aldrich, Melinda C., primary, Schwartz, Ann G., primary, Gorlov, Ivan, primary, Purrington, Kristen S., primary, Yang, Ping, primary, Liu, Yanhong, primary, Bailey-Wilson, Joan E., primary, Pinney, Susan M., primary, Mandal, Diptasri, primary, Willey, James C., primary, Gaba, Colette, primary, Brennan, Paul, primary, Xia, Jun, primary, Shen, Hongbing, primary, and Amos, Christopher I., primary
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- 2024
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18. Figure S4 from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies
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Li, Yafang, primary, Xiao, Xiangjun, primary, Li, Jianrong, primary, Han, Younghun, primary, Cheng, Chao, primary, Fernandes, Gail F., primary, Slewitzke, Shannon E., primary, Rosenberg, Susan M., primary, Zhu, Meng, primary, Byun, Jinyoung, primary, Bossé, Yohan, primary, McKay, James D., primary, Albanes, Demetrios, primary, Lam, Stephen, primary, Tardon, Adonina, primary, Chen, Chu, primary, Bojesen, Stig E., primary, Landi, Maria T., primary, Johansson, Mattias, primary, Risch, Angela, primary, Bickeböller, Heike, primary, Wichmann, H-Erich, primary, Christiani, David C., primary, Rennert, Gad, primary, Arnold, Susanne M., primary, Goodman, Gary E., primary, Field, John K., primary, Davies, Michael P.A., primary, Shete, Sanjay, primary, Marchand, Loïc Le, primary, Liu, Geoffrey, primary, Hung, Rayjean J., primary, Andrew, Angeline S., primary, Kiemeney, Lambertus A., primary, Sun, Ryan, primary, Zienolddiny, Shanbeh, primary, Grankvist, Kjell, primary, Johansson, Mikael, primary, Caporaso, Neil E., primary, Cox, Angela, primary, Hong, Yun-Chul, primary, Lazarus, Philip, primary, Schabath, Matthew B., primary, Aldrich, Melinda C., primary, Schwartz, Ann G., primary, Gorlov, Ivan, primary, Purrington, Kristen S., primary, Yang, Ping, primary, Liu, Yanhong, primary, Bailey-Wilson, Joan E., primary, Pinney, Susan M., primary, Mandal, Diptasri, primary, Willey, James C., primary, Gaba, Colette, primary, Brennan, Paul, primary, Xia, Jun, primary, Shen, Hongbing, primary, and Amos, Christopher I., primary
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- 2024
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19. Obesity, metabolic factors and risk of different histological types of lung cancer: A Mendelian randomization study
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Carreras-Torres, Robert, Johansson, Mattias, Haycock, Philip C, Wade, Kaitlin H, Relton, Caroline L, Martin, Richard M, Smith, George Davey, Albanes, Demetrius, Aldrich, Melinda C, Andrew, Angeline, Arnold, Susanne M, Bickeböller, Heike, Bojesen, Stig E, Brunnström, Hans, Manjer, Jonas, Brüske, Irene, Caporaso, Neil E, Chen, Chu, Christiani, David C, Christian, W Jay, Doherty, Jennifer A, Duell, Eric J, Field, John K, Davies, Michael PA, Marcus, Michael W, Goodman, Gary E, Grankvist, Kjell, Haugen, Aage, Hong, Yun-Chul, Kiemeney, Lambertus A, van der Heijden, Erik HFM, Kraft, Peter, Johansson, Mikael B, Lam, Stephen, Landi, Maria Teresa, Lazarus, Philip, Le Marchand, Loïc, Liu, Geoffrey, Melander, Olle, Park, Sungshim L, Rennert, Gad, Risch, Angela, Haura, Eric B, Scelo, Ghislaine, Zaridze, David, Mukeriya, Anush, Savić, Milan, Lissowska, Jolanta, Swiatkowska, Beata, Janout, Vladimir, Holcatova, Ivana, Mates, Dana, Schabath, Matthew B, Shen, Hongbing, Tardon, Adonina, Teare, M Dawn, Woll, Penella, Tsao, Ming-Sound, Wu, Xifeng, Yuan, Jian-Min, Hung, Rayjean J, Amos, Christopher I, McKay, James, and Brennan, Paul
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Epidemiology ,Biomedical and Clinical Sciences ,Health Sciences ,Oncology and Carcinogenesis ,Genetics ,Lung ,Nutrition ,Tobacco Smoke and Health ,Prevention ,Cancer ,Tobacco ,Obesity ,Clinical Research ,Lung Cancer ,Aetiology ,2.1 Biological and endogenous factors ,Body Mass Index ,Fasting ,Humans ,Insulin ,Insulin Resistance ,Likelihood Functions ,Lipids ,Lung Neoplasms ,Mendelian Randomization Analysis ,Phenotype ,Polymorphism ,Single Nucleotide ,Risk Factors ,General Science & Technology - Abstract
BackgroundAssessing the relationship between lung cancer and metabolic conditions is challenging because of the confounding effect of tobacco. Mendelian randomization (MR), or the use of genetic instrumental variables to assess causality, may help to identify the metabolic drivers of lung cancer.Methods and findingsWe identified genetic instruments for potential metabolic risk factors and evaluated these in relation to risk using 29,266 lung cancer cases (including 11,273 adenocarcinomas, 7,426 squamous cell and 2,664 small cell cases) and 56,450 controls. The MR risk analysis suggested a causal effect of body mass index (BMI) on lung cancer risk for two of the three major histological subtypes, with evidence of a risk increase for squamous cell carcinoma (odds ratio (OR) [95% confidence interval (CI)] = 1.20 [1.01-1.43] and for small cell lung cancer (OR [95%CI] = 1.52 [1.15-2.00]) for each standard deviation (SD) increase in BMI [4.6 kg/m2]), but not for adenocarcinoma (OR [95%CI] = 0.93 [0.79-1.08]) (Pheterogeneity = 4.3x10-3). Additional analysis using a genetic instrument for BMI showed that each SD increase in BMI increased cigarette consumption by 1.27 cigarettes per day (P = 2.1x10-3), providing novel evidence that a genetic susceptibility to obesity influences smoking patterns. There was also evidence that low-density lipoprotein cholesterol was inversely associated with lung cancer overall risk (OR [95%CI] = 0.90 [0.84-0.97] per SD of 38 mg/dl), while fasting insulin was positively associated (OR [95%CI] = 1.63 [1.25-2.13] per SD of 44.4 pmol/l). Sensitivity analyses including a weighted-median approach and MR-Egger test did not detect other pleiotropic effects biasing the main results.ConclusionsOur results are consistent with a causal role of fasting insulin and low-density lipoprotein cholesterol in lung cancer etiology, as well as for BMI in squamous cell and small cell carcinoma. The latter relation may be mediated by a previously unrecognized effect of obesity on smoking behavior.
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- 2017
20. Lung cancer in ever- and never-smokers : findings from multi-population GWAS studies
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Li, Yafang, Xiao, Xiangjun, Li, Jianrong, Han, Younghun, Cheng, Chao, Fernandes, Gail F., Slewitzke, Shannon E., Rosenberg, Susan M., Zhu, Meng, Byun, Jinyoung, Bossé, Yohan, McKay, James D., Albanes, Demetrios, Lam, Stephen, Tardon, Adonina, Chen, Chu, Bojesen, Stig E., Landi, Maria T., Johansson, Mattias, Risch, Angela, Bickeböller, Heike, Wichmann, H-Erich, Christiani, David C., Rennert, Gad, Arnold, Susanne M., Goodman, Gary E., Field, John K., Davies, Michael P A, Shete, Sanjay, Marchand, Loïc Le, Liu, Geoffrey, Hung, Rayjean J., Andrew, Angeline S., Kiemeney, Lambertus A., Sun, Ryan, Zienolddiny, Shanbeh, Grankvist, Kjell, Johansson, Mikael, Caporaso, Neil E., Cox, Angela, Hong, Yun-Chul, Lazarus, Philip, Schabath, Matthew B., Aldrich, Melinda C., Schwartz, Ann G., Gorlov, Ivan, Purrington, Kristen S., Yang, Ping, Liu, Yanhong, Bailey-Wilson, Joan E., Pinney, Susan M., Mandal, Diptasri, Willey, James C., Gaba, Colette, Brennan, Paul, Xia, Jun, Shen, Hongbing, Amos, Christopher I., Li, Yafang, Xiao, Xiangjun, Li, Jianrong, Han, Younghun, Cheng, Chao, Fernandes, Gail F., Slewitzke, Shannon E., Rosenberg, Susan M., Zhu, Meng, Byun, Jinyoung, Bossé, Yohan, McKay, James D., Albanes, Demetrios, Lam, Stephen, Tardon, Adonina, Chen, Chu, Bojesen, Stig E., Landi, Maria T., Johansson, Mattias, Risch, Angela, Bickeböller, Heike, Wichmann, H-Erich, Christiani, David C., Rennert, Gad, Arnold, Susanne M., Goodman, Gary E., Field, John K., Davies, Michael P A, Shete, Sanjay, Marchand, Loïc Le, Liu, Geoffrey, Hung, Rayjean J., Andrew, Angeline S., Kiemeney, Lambertus A., Sun, Ryan, Zienolddiny, Shanbeh, Grankvist, Kjell, Johansson, Mikael, Caporaso, Neil E., Cox, Angela, Hong, Yun-Chul, Lazarus, Philip, Schabath, Matthew B., Aldrich, Melinda C., Schwartz, Ann G., Gorlov, Ivan, Purrington, Kristen S., Yang, Ping, Liu, Yanhong, Bailey-Wilson, Joan E., Pinney, Susan M., Mandal, Diptasri, Willey, James C., Gaba, Colette, Brennan, Paul, Xia, Jun, Shen, Hongbing, and Amos, Christopher I.
- Abstract
BACKGROUND: Clinical, molecular, and genetic epidemiology studies displayed remarkable differences between ever- and never-smoking lung cancer. METHODS: We conducted a stratified multi-population (European, East Asian, and African descent) association study on 44,823 ever-smokers and 20,074 never-smokers to identify novel variants that were missed in the non-stratified analysis. Functional analysis including expression quantitative trait loci (eQTL) colocalization and DNA damage assays, and annotation studies were conducted to evaluate the functional roles of the variants. We further evaluated the impact of smoking quantity on lung cancer risk for the variants associated with ever-smoking lung cancer. RESULTS: Five novel independent loci, GABRA4, intergenic region 12q24.33, LRRC4C, LINC01088, and LCNL1 were identified with the association at two or three populations (P < 5 × 10-8). Further functional analysis provided multiple lines of evidence suggesting the variants affect lung cancer risk through excessive DNA damage (GABRA4) or cis-regulation of gene expression (LCNL1). The risk of variants from 12 independent regions, including the well-known CHRNA5, associated with ever-smoking lung cancer was evaluated for never-smokers, light-smokers (packyear ≤ 20), and moderate-to-heavy-smokers (packyear > 20). Different risk patterns were observed for the variants among the different groups by smoking behavior. CONCLUSIONS: We identified novel variants associated with lung cancer in only ever- or never-smoking groups that were missed by prior main-effect association studies. IMPACT: Our study highlights the genetic heterogeneity between ever- and never-smoking lung cancer and provides etiologic insights into the complicated genetic architecture of this deadly cancer.
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- 2024
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21. On the informative value of community‐based indoor radon values in relation to lung cancer.
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Rosenberger, Albert, Bickeböller, Heike, Christiani, David C., Liu, Geoffrey, Schabath, Matthew B., Duarte, Luisa F., Le Marchand, Loic, Haiman, Christopher, Landi, Teresa, Consonni, Dario, Field, John K., Davies, Michael P. A., Albanes, Demetrios, Tardón, Adonina, Fernández‐Tardón, Guillermo, Rennert, Gad, Amos, Christopher I., and Hung, Rayjean J.
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SMALL cell lung cancer , *LUNG cancer , *SQUAMOUS cell carcinoma , *RADON , *RESIDENTIAL areas - Abstract
Background: Radon is a radioactive gas and a major risk factor for lung cancer (LC). Methods: We investigated the dose–response relationship between radon and LC risk in the International Lung Cancer Consortium with 8927 cases and 5562 controls from Europe, North America, and Israel, conducted between 1992 and 2016. Spatial indoor radon exposure in the residential area (sIR) obtained from national surveys was linked to the participants' residential geolocation. Parametric linear and spline functions were fitted within a logistic regression framework. Results: We observed a non‐linear spatial‐dose response relationship for sIR < 200 Bq/m3. The lowest risk was observed for areas of mean exposure of 58 Bq/m3 (95% CI: 56.1–59.2 Bq/m3). The relative risk of lung cancer increased to the same degree in areas averaging 25 Bq/m3 (OR = 1.31, 95% CI: 1.01–1.59) as in areas with a mean of 100 Bq/m3 (OR = 1.34, 95% CI: 1.20–1.45). The strongest association was observed for small cell lung cancer and the weakest for squamous cell carcinoma. A stronger association was also observed in men, but only at higher exposure levels. The non‐linear association is primarily observed among the younger population (age < 69 years), but not in the older population, which can potentially represent different biological radiation responses. Conclusions: The sIR is useful as proxy of individual radon exposure in epidemiological studies on lung cancer. The usual assumption of a linear, no‐threshold dose–response relationship, as can be made for individual radon exposures, may not be optimal for sIR values of less than 200 Bq/m3. [ABSTRACT FROM AUTHOR]
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- 2024
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22. Genetisch-molekulare Grundlagen von Gesundheit und Krankheit
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Bickeböller, Heike and Haring, Robin, editor
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- 2019
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23. Supplementary Materials from CYP2A6 Activity and Cigarette Consumption Interact in Smoking-Related Lung Cancer Susceptibility
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Du, Mulong, primary, Xin, Junyi, primary, Zheng, Rui, primary, Yuan, Qianyu, primary, Wang, Zhihui, primary, Liu, Hongliang, primary, Liu, Hanting, primary, Cai, Guoshuai, primary, Albanes, Demetrius, primary, Lam, Stephen, primary, Tardon, Adonina, primary, Chen, Chu, primary, Bojesen, Stig E., primary, Landi, Maria Teresa, primary, Johansson, Mattias, primary, Risch, Angela, primary, Bickeböller, Heike, primary, Wichmann, H-Erich, primary, Rennert, Gad, primary, Arnold, Susanne, primary, Brennan, Paul, primary, Field, John K., primary, Shete, Sanjay S., primary, Le Marchand, Loïc, primary, Liu, Geoffrey, primary, Andrew, Angeline S., primary, Kiemeney, Lambertus A., primary, Zienolddiny, Shan, primary, Grankvist, Kjell, primary, Johansson, Mikael, primary, Caporaso, Neil E., primary, Cox, Angela, primary, Hong, Yun-Chul, primary, Yuan, Jian-Min, primary, Schabath, Matthew B., primary, Aldrich, Melinda C., primary, Wang, Meilin, primary, Shen, Hongbing, primary, Chen, Feng, primary, Zhang, Zhengdong, primary, Hung, Rayjean J., primary, Amos, Christopher I., primary, Wei, Qingyi, primary, Lazarus, Philip, primary, and Christiani, David C., primary
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- 2024
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24. Data from CYP2A6 Activity and Cigarette Consumption Interact in Smoking-Related Lung Cancer Susceptibility
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Du, Mulong, primary, Xin, Junyi, primary, Zheng, Rui, primary, Yuan, Qianyu, primary, Wang, Zhihui, primary, Liu, Hongliang, primary, Liu, Hanting, primary, Cai, Guoshuai, primary, Albanes, Demetrius, primary, Lam, Stephen, primary, Tardon, Adonina, primary, Chen, Chu, primary, Bojesen, Stig E., primary, Landi, Maria Teresa, primary, Johansson, Mattias, primary, Risch, Angela, primary, Bickeböller, Heike, primary, Wichmann, H-Erich, primary, Rennert, Gad, primary, Arnold, Susanne, primary, Brennan, Paul, primary, Field, John K., primary, Shete, Sanjay S., primary, Le Marchand, Loïc, primary, Liu, Geoffrey, primary, Andrew, Angeline S., primary, Kiemeney, Lambertus A., primary, Zienolddiny, Shan, primary, Grankvist, Kjell, primary, Johansson, Mikael, primary, Caporaso, Neil E., primary, Cox, Angela, primary, Hong, Yun-Chul, primary, Yuan, Jian-Min, primary, Schabath, Matthew B., primary, Aldrich, Melinda C., primary, Wang, Meilin, primary, Shen, Hongbing, primary, Chen, Feng, primary, Zhang, Zhengdong, primary, Hung, Rayjean J., primary, Amos, Christopher I., primary, Wei, Qingyi, primary, Lazarus, Philip, primary, and Christiani, David C., primary
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- 2024
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25. Supplementary Tables1-11 from CYP2A6 Activity and Cigarette Consumption Interact in Smoking-Related Lung Cancer Susceptibility
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Du, Mulong, primary, Xin, Junyi, primary, Zheng, Rui, primary, Yuan, Qianyu, primary, Wang, Zhihui, primary, Liu, Hongliang, primary, Liu, Hanting, primary, Cai, Guoshuai, primary, Albanes, Demetrius, primary, Lam, Stephen, primary, Tardon, Adonina, primary, Chen, Chu, primary, Bojesen, Stig E., primary, Landi, Maria Teresa, primary, Johansson, Mattias, primary, Risch, Angela, primary, Bickeböller, Heike, primary, Wichmann, H-Erich, primary, Rennert, Gad, primary, Arnold, Susanne, primary, Brennan, Paul, primary, Field, John K., primary, Shete, Sanjay S., primary, Le Marchand, Loïc, primary, Liu, Geoffrey, primary, Andrew, Angeline S., primary, Kiemeney, Lambertus A., primary, Zienolddiny, Shan, primary, Grankvist, Kjell, primary, Johansson, Mikael, primary, Caporaso, Neil E., primary, Cox, Angela, primary, Hong, Yun-Chul, primary, Yuan, Jian-Min, primary, Schabath, Matthew B., primary, Aldrich, Melinda C., primary, Wang, Meilin, primary, Shen, Hongbing, primary, Chen, Feng, primary, Zhang, Zhengdong, primary, Hung, Rayjean J., primary, Amos, Christopher I., primary, Wei, Qingyi, primary, Lazarus, Philip, primary, and Christiani, David C., primary
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- 2024
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26. A genome-wide association study on hematopoietic stem cell transplantation reveals novel genomic loci associated with transplant outcomes
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Rosenberger, Albert, primary, Crossland, Rachel E., additional, Dressel, Ralf, additional, Kube, Dieter, additional, Wolff, Daniel, additional, Wulf, Gerald, additional, Bickeböller, Heike, additional, Dickinson, Anne, additional, and Holler, Ernst, additional
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- 2024
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27. Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis
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Yarmolinsky, James, primary, Robinson, Jamie W., additional, Mariosa, Daniela, additional, Karhunen, Ville, additional, Huang, Jian, additional, Dimou, Niki, additional, Murphy, Neil, additional, Burrows, Kimberley, additional, Bouras, Emmanouil, additional, Smith-Byrne, Karl, additional, Lewis, Sarah J., additional, Galesloot, Tessel E., additional, Kiemeney, Lambertus A., additional, Vermeulen, Sita, additional, Martin, Paul, additional, Albanes, Demetrius, additional, Hou, Lifang, additional, Newcomb, Polly A., additional, White, Emily, additional, Wolk, Alicja, additional, Wu, Anna H., additional, Le Marchand, Loïc, additional, Phipps, Amanda I., additional, Buchanan, Daniel D., additional, Zhao, Sizheng Steven, additional, Gill, Dipender, additional, Chanock, Stephen J., additional, Purdue, Mark P., additional, Davey Smith, George, additional, Brennan, Paul, additional, Herzig, Karl-Heinz, additional, Järvelin, Marjo-Riitta, additional, Amos, Chris I., additional, Hung, Rayjean J., additional, Dehghan, Abbas, additional, Johansson, Mattias, additional, Gunter, Marc J., additional, Tsilidis, Kostas K., additional, Martin, Richard M., additional, Landi, Maria Teresa, additional, Stevens, Victoria, additional, Wang, Ying, additional, Albanes, Demetrios, additional, Caporaso, Neil, additional, Amos, Christopher I., additional, Shete, Sanjay, additional, Bickeböller, Heike, additional, Risch, Angela, additional, Houlston, Richard, additional, Lam, Stephen, additional, Tardon, Adonina, additional, Chen, Chu, additional, Bojesen, Stig E., additional, Wichmann, H-Erich, additional, Christiani, David, additional, Rennert, Gadi, additional, Arnold, Susanne, additional, Field, John K., additional, Le Marchand, Loic, additional, Melander, Olle, additional, Brunnström, Hans, additional, Liu, Geoffrey, additional, Andrew, Angeline, additional, Shen, Hongbing, additional, Zienolddiny, Shan, additional, Grankvist, Kjell, additional, Johansson, Mikael, additional, Teare, M. Dawn, additional, Hong, Yun-Chul, additional, Yuan, Jian-Min, additional, Lazarus, Philip, additional, Schabath, Matthew B., additional, Aldrich, Melinda C., additional, Eeles, Rosalind A., additional, Haiman, Christopher A., additional, Kote-Jarai, Zsofia, additional, Schumacher, Fredrick R., additional, Benlloch, Sara, additional, Al Olama, Ali Amin, additional, Muir, Kenneth R., additional, Berndt, Sonja I., additional, Conti, David V., additional, Wiklund, Fredrik, additional, Chanock, Stephen, additional, Tangen, Catherine M., additional, Batra, Jyotsna, additional, Clements, Judith A., additional, Grönberg, Henrik, additional, Pashayan, Nora, additional, Schleutker, Johanna, additional, Weinstein, Stephanie J., additional, West, Catharine M.L., additional, Mucci, Lorelei A., additional, Cancel-Tassin, Géraldine, additional, Koutros, Stella, additional, Sørensen, Karina Dalsgaard, additional, Grindedal, Eli Marie, additional, Neal, David E., additional, Hamdy, Freddie C., additional, Donovan, Jenny L., additional, Travis, Ruth C., additional, Hamilton, Robert J., additional, Ingles, Sue Ann, additional, Rosenstein, Barry S., additional, Lu, Yong-Jie, additional, Giles, Graham G., additional, MacInnis, Robert J., additional, Kibel, Adam S., additional, Vega, Ana, additional, Kogevinas, Manolis, additional, Penney, Kathryn L., additional, Park, Jong Y., additional, Stanfrod, Janet L., additional, Cybulski, Cezary, additional, Nordestgaard, Børge G., additional, Nielsen, Sune F., additional, Brenner, Hermann, additional, Maier, Christiane, additional, Logothetis, Christopher J., additional, John, Esther M., additional, Teixeira, Manuel R., additional, Neuhausen, Susan L., additional, De Ruyck, Kim, additional, Razack, Azad, additional, Newcomb, Lisa F., additional, Lessel, Davor, additional, Kaneva, Radka, additional, Usmani, Nawaid, additional, Claessens, Frank, additional, Townsend, Paul A., additional, Castelao, Jose Esteban, additional, Roobol, Monique J., additional, Menegaux, Florence, additional, Khaw, Kay-Tee, additional, Cannon-Albright, Lisa, additional, Pandha, Hardev, additional, Thibodeau, Stephen N., additional, Hunter, David J., additional, Kraft, Peter, additional, Blot, William J., additional, and Riboli, Elio, additional
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- 2024
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28. Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies
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Li, Yafang, primary, Xiao, Xiangjun, additional, Li, Jianrong, additional, Han, Younghun, additional, Cheng, Chao, additional, Fernandes, Gail F., additional, Slewitzke, Shannon E., additional, Rosenberg, Susan M., additional, Zhu, Meng, additional, Byun, Jinyoung, additional, Bossé, Yohan, additional, McKay, James D., additional, Albanes, Demetrios, additional, Lam, Stephen, additional, Tardon, Adonina, additional, Chen, Chu, additional, Bojesen, Stig E., additional, Landi, Maria T., additional, Johansson, Mattias, additional, Risch, Angela, additional, Bickeböller, Heike, additional, Wichmann, H-Erich, additional, Christiani, David C., additional, Rennert, Gad, additional, Arnold, Susanne M., additional, Goodman, Gary E., additional, Field, John K., additional, Davies, Michael P.A., additional, Shete, Sanjay, additional, Marchand, Loïc Le, additional, Liu, Geoffrey, additional, Hung, Rayjean J., additional, Andrew, Angeline S., additional, Kiemeney, Lambertus A., additional, Sun, Ryan, additional, Zienolddiny, Shanbeh, additional, Grankvist, Kjell, additional, Johansson, Mikael, additional, Caporaso, Neil E., additional, Cox, Angela, additional, Hong, Yun-Chul, additional, Lazarus, Philip, additional, Schabath, Matthew B., additional, Aldrich, Melinda C., additional, Schwartz, Ann G., additional, Gorlov, Ivan, additional, Purrington, Kristen S., additional, Yang, Ping, additional, Liu, Yanhong, additional, Bailey-Wilson, Joan E., additional, Pinney, Susan M., additional, Mandal, Diptasri, additional, Willey, James C., additional, Gaba, Colette, additional, Brennan, Paul, additional, Xia, Jun, additional, Shen, Hongbing, additional, and Amos, Christopher I., additional
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- 2024
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29. CYP2A6 activity and cigarette consumption interact in smoking-related lung cancer susceptibility
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Du, Mulong, primary, Xin, Junyi, additional, Zheng, Rui, additional, Yuan, Qianyu, additional, Wang, Zhihui, additional, Liu, Hongliang, additional, Liu, Hanting, additional, Cai, Guoshuai, additional, Albanes, Demetrius, additional, Lam, Stephen, additional, Tardon, Adonina, additional, Chen, Chu, additional, Bojesen, Stig E., additional, Landi, Maria Teresa, additional, Johansson, Mattias, additional, Risch, Angela, additional, Bickeböller, Heike, additional, Wichmann, H-Erich, additional, Rennert, Gad, additional, Arnold, Susanne, additional, Brennan, Paul, additional, Field, John K., additional, Shete, Sanjay S., additional, Le Marchand, Loïc, additional, Liu, Geoffrey, additional, Andrew, Angeline S., additional, Kiemeney, Lambertus A., additional, Zienolddiny, Shanbeh, additional, Grankvist, Kjell, additional, Johansson, Mikael, additional, Caporaso, Neil E., additional, Cox, Angela, additional, Hong, Yun-Chul, additional, Yuan, Jian-Min, additional, Schabath, Matthew B., additional, Aldrich, Melinda C., additional, Wang, Meilin, additional, Shen, Hongbing, additional, Chen, Feng, additional, Zhang, Zhengdong, additional, Hung, Rayjean J., additional, Amos, Christopher I., additional, Wei, Qingyi, additional, Lazarus, Philip, additional, and Christiani, David C., additional
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- 2023
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30. Identification of genetically predicted DNA methylation markers associated with non–small cell lung cancer risk among 34,964 cases and 448,579 controls
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Zhao, Xiaoyu, primary, Yang, Meiqi, additional, Fan, Jingyi, additional, Wang, Mei, additional, Wang, Yifan, additional, Qin, Na, additional, Zhu, Meng, additional, Jiang, Yue, additional, Gorlova, Olga Y., additional, Gorlov, Ivan P., additional, Albanes, Demetrius, additional, Lam, Stephen, additional, Tardón, Adonina, additional, Chen, Chu, additional, Goodman, Gary E., additional, Bojesen, Stig E., additional, Landi, Maria Teresa, additional, Johansson, Mattias, additional, Risch, Angela, additional, Wichmann, H.‐Erich, additional, Bickeböller, Heike, additional, Christiani, David C., additional, Rennert, Gad, additional, Arnold, Susanne M., additional, Brennan, Paul, additional, Field, John K., additional, Shete, Sanjay, additional, Le Marchand, Loïc, additional, Liu, Geoffrey, additional, Hung, Rayjean J., additional, Andrew, Angeline S., additional, Kiemeney, Lambertus A., additional, Zienolddiny, Shanbeh, additional, Grankvist, Kjell, additional, Johansson, Mikael, additional, Caporaso, Neil E., additional, Woll, Penella J., additional, Lazarus, Philip, additional, Schabath, Matthew B., additional, Aldrich, Melinda C., additional, Patel, Alpa V., additional, Davies, Michael P. A., additional, Ma, Hongxia, additional, Jin, Guangfu, additional, Hu, Zhibin, additional, Amos, Christopher I., additional, Shen, Hongbing, additional, and Dai, Juncheng, additional
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- 2023
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31. CHRNA5 Risk Variant Predicts Delayed Smoking Cessation and Earlier Lung Cancer Diagnosis—A Meta-Analysis
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Chen, Li-Shiun, Hung, Rayjean J, Baker, Timothy, Horton, Amy, Culverhouse, Rob, Saccone, Nancy, Cheng, Iona, Deng, Bo, Han, Younghun, Hansen, Helen M, Horsman, Janet, Kim, Claire, Lutz, Sharon, Rosenberger, Albert, Aben, Katja K, Andrew, Angeline S, Breslau, Naomi, Chang, Shen-Chih, Dieffenbach, Aida Karina, Dienemann, Hendrik, Frederiksen, Brittni, Han, Jiali, Hatsukami, Dorothy K, Johnson, Eric O, Pande, Mala, Wrensch, Margaret R, McLaughlin, John, Skaug, Vidar, van der Heijden, Henricus F, Wampfler, Jason, Wenzlaff, Angela, Woll, Penella, Zienolddiny, Shanbeh, Bickeböller, Heike, Brenner, Hermann, Duell, Eric J, Haugen, Aage, Heinrich, Joachim, Hokanson, John E, Hunter, David J, Kiemeney, Lambertus A, Lazarus, Philip, Le Marchand, Loic, Liu, Geoffrey, Mayordomo, Jose, Risch, Angela, Schwartz, Ann G, Teare, Dawn, Wu, Xifeng, Wiencke, John K, Yang, Ping, Zhang, Zuo-Feng, Spitz, Margaret R, Kraft, Peter, Amos, Christopher I, and Bierut, Laura J
- Subjects
Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Clinical Research ,Lung ,Lung Cancer ,Cancer ,Human Genome ,Tobacco ,Prevention ,Genetics ,Tobacco Smoke and Health ,Detection ,screening and diagnosis ,4.2 Evaluation of markers and technologies ,Respiratory ,Good Health and Well Being ,Genetic Variation ,Humans ,Lung Neoplasms ,Middle Aged ,Nerve Tissue Proteins ,Phenotype ,Receptors ,Nicotinic ,Risk Factors ,Smoking ,Smoking Cessation ,Time Factors ,Oncology & Carcinogenesis ,Oncology and carcinogenesis - Abstract
BackgroundRecent meta-analyses show strong evidence of associations among genetic variants in CHRNA5 on chromosome 15q25, smoking quantity, and lung cancer. This meta-analysis tests whether the CHRNA5 variant rs16969968 predicts age of smoking cessation and age of lung cancer diagnosis.MethodsMeta-analyses examined associations between rs16969968, age of quitting smoking, and age of lung cancer diagnosis in 24 studies of European ancestry (n = 29 072). In each dataset, we used Cox regression models to evaluate the association between rs16969968 and the two primary phenotypes (age of smoking cessation among ever smokers and age of lung cancer diagnosis among lung cancer case patients) and the secondary phenotype of smoking duration. Heterogeneity across studies was assessed with the Cochran Q test. All statistical tests were two-sided.ResultsThe rs16969968 allele (A) was associated with a lower likelihood of smoking cessation (hazard ratio [HR] = 0.95, 95% confidence interval [CI] = 0.91 to 0.98, P = .0042), and the AA genotype was associated with a four-year delay in median age of quitting compared with the GG genotype. Among smokers with lung cancer diagnoses, the rs16969968 genotype (AA) was associated with a four-year earlier median age of diagnosis compared with the low-risk genotype (GG) (HR = 1.08, 95% CI = 1.04 to 1.12, P = 1.1*10(-5)).ConclusionThese data support the clinical significance of the CHRNA5 variant rs16969968. It predicts delayed smoking cessation and an earlier age of lung cancer diagnosis in this meta-analysis. Given the existing evidence that this CHRNA5 variant predicts favorable response to cessation pharmacotherapy, these findings underscore the potential clinical and public health importance of rs16969968 in CHRNA5 in relation to smoking cessation success and lung cancer risk.
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- 2015
32. Efficient region-based test strategy uncovers genetic risk factors for functional outcome in bipolar disorder
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Budde, Monika, Friedrichs, Stefanie, Alliey-Rodriguez, Ney, Ament, Seth, Badner, Judith A., Berrettini, Wade H., Bloss, Cinnamon S., Byerley, William, Cichon, Sven, Comes, Ashley L., Coryell, William, Craig, David W., Degenhardt, Franziska, Edenberg, Howard J., Foroud, Tatiana, Forstner, Andreas J., Frank, Josef, Gershon, Elliot S., Goes, Fernando S., Greenwood, Tiffany A., Guo, Yiran, Hipolito, Maria, Hood, Leroy, Keating, Brendan J., Koller, Daniel L., Lawson, William B., Liu, Chunyu, Mahon, Pamela B., McInnis, Melvin G., McMahon, Francis J., Meier, Sandra M., Mühleisen, Thomas W., Murray, Sarah S., Nievergelt, Caroline M., Nurnberger, John I., Jr., Nwulia, Evaristus A., Potash, James B., Quarless, Danjuma, Rice, John, Roach, Jared C., Scheftner, William A., Schork, Nicholas J., Shekhtman, Tatyana, Shilling, Paul D., Smith, Erin N., Streit, Fabian, Strohmaier, Jana, Szelinger, Szabolcs, Treutlein, Jens, Witt, Stephanie H., Zandi, Peter P., Zhang, Peng, Zöllner, Sebastian, Bickeböller, Heike, Falkai, Peter G., Kelsoe, John R., Nöthen, Markus M., Rietschel, Marcella, Schulze, Thomas G., and Malzahn, Dörthe
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- 2019
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33. A genome-wide association study of the longitudinal course of executive functions
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Wendel, Bernadette, Papiol, Sergi, Andlauer, Till F. M., Zimmermann, Jörg, Wiltfang, Jens, Spitzer, Carsten, Senner, Fanny, Schulte, Eva C., Schmauß, Max, Schaupp, Sabrina K., Repple, Jonathan, Reininghaus, Eva, Reimer, Jens, Reich-Erkelenz, Daniela, Opel, Nils, Nenadić, Igor, Meinert, Susanne, Konrad, Carsten, Klöhn-Saghatolislam, Farahnaz, Kircher, Tilo, Kalman, Janos L., Juckel, Georg, Jansen, Andreas, Jäger, Markus, Heilbronner, Maria, von Hagen, Martin, Gade, Katrin, Figge, Christian, Fallgatter, Andreas J., Dietrich, Detlef E., Dannlowski, Udo, Comes, Ashley L., Budde, Monika, Baune, Bernhard T., Arolt, Volker, Anghelescu, Ion-George, Anderson-Schmidt, Heike, Adorjan, Kristina, Falkai, Peter, Schulze, Thomas G., Bickeböller, Heike, and Heilbronner, Urs
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- 2021
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34. Hierarchical modeling identifies novel lung cancer susceptibility variants in inflammation pathways among 10,140 cases and 11,012 controls
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Brenner, Darren R, Brennan, Paul, Boffetta, Paolo, Amos, Christopher I, Spitz, Margaret R, Chen, Chu, Goodman, Gary, Heinrich, Joachim, Bickeböller, Heike, Rosenberger, Albert, Risch, Angela, Muley, Thomas, McLaughlin, John R, Benhamou, Simone, Bouchardy, Christine, Lewinger, Juan Pablo, Witte, John S, Chen, Gary, Bull, Shelley, and Hung, Rayjean J
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Biological Sciences ,Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Genetics ,Prevention ,Lung Cancer ,Human Genome ,Lung ,Cancer ,Aetiology ,2.1 Biological and endogenous factors ,Alleles ,Canada ,Case-Control Studies ,Europe ,Female ,Gene Frequency ,Genetic Predisposition to Disease ,Genetic Variation ,Genome-Wide Association Study ,Genotype ,Humans ,Inflammation ,Likelihood Functions ,Lung Neoplasms ,Male ,Middle Aged ,Models ,Statistical ,Polymorphism ,Single Nucleotide ,Risk ,United States ,White People ,Complementary and Alternative Medicine ,Paediatrics and Reproductive Medicine ,Genetics & Heredity ,Reproductive medicine - Abstract
Recent evidence suggests that inflammation plays a pivotal role in the development of lung cancer. In this study, we used a two-stage approach to investigate associations between genetic variants in inflammation pathways and lung cancer risk based on genome-wide association study (GWAS) data. A total of 7,650 sequence variants from 720 genes relevant to inflammation pathways were identified using keyword and pathway searches from Gene Cards and Gene Ontology databases. In Stage 1, six GWAS datasets from the International Lung Cancer Consortium were pooled (4,441 cases and 5,094 controls of European ancestry), and a hierarchical modeling (HM) approach was used to incorporate prior information for each of the variants into the analysis. The prior matrix was constructed using (1) role of genes in the inflammation and immune pathways; (2) physical properties of the variants including the location of the variants, their conservation scores and amino acid coding; (3) LD with other functional variants and (4) measures of heterogeneity across the studies. HM affected the priority ranking of variants particularly among those having low prior weights, imprecise estimates and/or heterogeneity across studies. In Stage 2, we used an independent NCI lung cancer GWAS study (5,699 cases and 5,818 controls) for in silico replication. We identified one novel variant at the level corrected for multiple comparisons (rs2741354 in EPHX2 at 8p21.1 with p value = 7.4 × 10(-6)), and confirmed the associations between TERT (rs2736100) and the HLA region and lung cancer risk. HM allows for prior knowledge such as from bioinformatic sources to be incorporated into the analysis systematically, and it represents a complementary analytical approach to the conventional GWAS analysis.
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- 2013
35. Global, pathway and gene coverage of three Illumina arrays with respect to inflammatory and immune-related pathways
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Tozzi, Viola, Rosenberger, Albert, Kube, Dieter, and Bickeböller, Heike
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- 2019
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36. Previous Lung Diseases and Lung Cancer Risk: A Pooled Analysis From the International Lung Cancer Consortium
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Brenner, Darren R, Boffetta, Paolo, Duell, Eric J, Bickeböller, Heike, Rosenberger, Albert, McCormack, Valerie, Muscat, Joshua E, Yang, Ping, Wichmann, H-Erich, Brueske-Hohlfeld, Irene, Schwartz, Ann G, Cote, Michele L, Tjønneland, Anne, Friis, Søren, Le Marchand, Loic, Zhang, Zuo-Feng, Morgenstern, Hal, Szeszenia-Dabrowska, Neonila, Lissowska, Jolanta, Zaridze, David, Rudnai, Peter, Fabianova, Eleonora, Foretova, Lenka, Janout, Vladimir, Bencko, Vladimir, Schejbalova, Miriam, Brennan, Paul, Mates, Ioan N, Lazarus, Philip, Field, John K, Raji, Olaide, McLaughlin, John R, Liu, Geoffrey, Wiencke, John, Neri, Monica, Ugolini, Donatella, Andrew, Angeline S, Lan, Qing, Hu, Wei, Orlow, Irene, Park, Bernard J, and Hung, Rayjean J
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Epidemiology ,Health Services and Systems ,Health Sciences ,Chronic Obstructive Pulmonary Disease ,Pneumonia ,Prevention ,Lung ,Tobacco Smoke and Health ,Cancer ,Tobacco ,Rare Diseases ,Pneumonia & Influenza ,Lung Cancer ,Infectious Diseases ,Respiratory ,Good Health and Well Being ,Bronchitis ,Chronic ,Humans ,Logistic Models ,Lung Neoplasms ,Proportional Hazards Models ,Pulmonary Emphysema ,Risk ,Risk Factors ,Self Report ,Tuberculosis ,Pulmonary ,bronchitis ,chronic ,emphysema ,lung diseases ,lung neoplasms ,meta-analysis ,pneumonia ,pulmonary disease ,chronic obstructive ,tuberculosis ,Mathematical Sciences ,Medical and Health Sciences - Abstract
To clarify the role of previous lung diseases (chronic bronchitis, emphysema, pneumonia, and tuberculosis) in the development of lung cancer, the authors conducted a pooled analysis of studies in the International Lung Cancer Consortium. Seventeen studies including 24,607 cases and 81,829 controls (noncases), mainly conducted in Europe and North America, were included (1984-2011). Using self-reported data on previous diagnoses of lung diseases, the authors derived study-specific effect estimates by means of logistic regression models or Cox proportional hazards models adjusted for age, sex, and cumulative tobacco smoking. Estimates were pooled using random-effects models. Analyses stratified by smoking status and histology were also conducted. A history of emphysema conferred a 2.44-fold increased risk of lung cancer (95% confidence interval (CI): 1.64, 3.62 (16 studies)). A history of chronic bronchitis conferred a relative risk of 1.47 (95% CI: 1.29, 1.68 (13 studies)). Tuberculosis (relative risk = 1.48, 95% CI: 1.17, 1.87 (16 studies)) and pneumonia (relative risk = 1.57, 95% CI: 1.22, 2.01 (12 studies)) were also associated with lung cancer risk. Among never smokers, elevated risks were observed for emphysema, pneumonia, and tuberculosis. These results suggest that previous lung diseases influence lung cancer risk independently of tobacco use and that these diseases are important for assessing individual risk.
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- 2012
37. Identifying rare variants from exome scans: the GAW17 experience
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Ghosh, Saurabh, Bickeböller, Heike, Bailey, Julia, Bailey-Wilson, Joan E, Cantor, Rita, Culverhouse, Robert, Daw, Warwick, DeStefano, Anita L, Engelman, Corinne D, Hinrichs, Anthony, Houwing-Duistermaat, Jeanine, König, Inke R, Kent, Jack, Laird, Nan, Pankratz, Nathan, Paterson, Andrew, Pugh, Elizabeth, Suarez, Brian, Sun, Yan, Thomas, Alun, Tintle, Nathan, Zhu, Xiaofeng, Ziegler, Andreas, MacCluer, Jean W, and Almasy, Laura
- Abstract
Abstract Genetic Analysis Workshop 17 (GAW17) provided a platform for evaluating existing statistical genetic methods and for developing novel methods to analyze rare variants that modulate complex traits. In this article, we present an overview of the 1000 Genomes Project exome data and simulated phenotype data that were distributed to GAW17 participants for analyses, the different issues addressed by the participants, and the process of preparation of manuscripts resulting from the discussions during the workshop.
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- 2011
38. Protein-altering germline mutations implicate novel genes related to lung cancer development
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Ji, Xuemei, Mukherjee, Semanti, Landi, Maria Teresa, Bosse, Yohan, Joubert, Philippe, Zhu, Dakai, Gorlov, Ivan, Xiao, Xiangjun, Han, Younghun, Gorlova, Olga, Hung, Rayjean J., Brhane, Yonathan, Carreras-Torres, Robert, Christiani, David C., Caporaso, Neil, Johansson, Mattias, Liu, Geoffrey, Bojesen, Stig E., Le Marchand, Loic, Albanes, Demetrios, Bickeböller, Heike, Aldrich, Melinda C., Bush, William S., Tardon, Adonina, Rennert, Gad, Chen, Chu, Byun, Jinyoung, Dragnev, Konstantin H., Field, John K., Kiemeney, Lambertus FA., Lazarus, Philip, Zienolddiny, Shan, Lam, Stephen, Schabath, Matthew B., Andrew, Angeline S., Bertazzi, Pier A., Pesatori, Angela C., Diao, Nancy, Su, Li, Song, Lei, Zhang, Ruyang, Leighl, Natasha, Johansen, Jakob S., Mellemgaard, Anders, Saliba, Walid, Haiman, Christopher, Wilkens, Lynne, Fernandez-Somoano, Ana, Fernandez-Tardon, Guillermo, Heijden, Erik H. F. M. van der, Kim, Jin Hee, Davies, Michael P. A., Marcus, Michael W., Brunnström, Hans, Manjer, Jonas, Melander, Olle, Muller, David C., Overvad, Kim, Trichopoulou, Antonia, Tumino, Rosario, Goodman, Gary E., Cox, Angela, Taylor, Fiona, Woll, Penella, Wichmann, Erich, Muley, Thomas, Risch, Angela, Rosenberger, Albert, Grankvist, Kjell, Johansson, Mikael, Shepherd, Frances, Tsao, Ming-Sound, Arnold, Susanne M., Haura, Eric B., Bolca, Ciprian, Holcatova, Ivana, Janout, Vladimir, Kontic, Milica, Lissowska, Jolanta, Mukeria, Anush, Ognjanovic, Simona, Orlowski, Tadeusz M., Scelo, Ghislaine, Swiatkowska, Beata, Zaridze, David, Bakke, Per, Skaug, Vidar, Butler, Lesley M., Offit, Kenneth, Srinivasan, Preethi, Bandlamudi, Chaitanya, Hellmann, Matthew D., Solit, David B., Robson, Mark E., Rudin, Charles M., Stadler, Zsofia K., Taylor, Barry S., Berger, Michael F., Houlston, Richard, McLaughlin, John, Stevens, Victoria, Nickle, David C., Obeidat, Ma’en, Timens, Wim, Artigas, María Soler, Shete, Sanjay, Brenner, Hermann, Chanock, Stephen, Brennan, Paul, McKay, James D., and Amos, Christopher I.
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- 2020
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39. Investigation of Linkage and Association: Issues on Study Design
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Bickeböller, Heike
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- 2000
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40. Genetic modifiers of radon-induced lung cancer risk: a genome-wide interaction study in former uranium miners
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Rosenberger, Albert, Hung, Rayjean J., Christiani, David C., Caporaso, Neil E., Liu, Geoffrey, Bojesen, Stig E., Le Marchand, Loic, Haiman, Ch. A., Albanes, Demetrios, Aldrich, Melinda C., Tardon, Adonina, Fernández-Tardón, G., Rennert, Gad, Field, John K., Kiemeney, B., Lazarus, Philip, Haugen, Aage, Zienolddiny, Shanbeh, Lam, Stephen, Schabath, Matthew B., Andrew, Angeline S., Brunnsstöm, Hans, Goodman, Gary E., Doherty, Jennifer A., Chen, Chu, Teare, M. Dawn, Wichmann, H.-Erich, Manz, Judith, Risch, Angela, Muley, Thomas R., Johansson, Mikael, Brennan, Paul, Landi, Maria Teresa, Amos, Christopher I., Pesch, Beate, Johnen, Georg, Brüning, Thomas, Bickeböller, Heike, and Gomolka, Maria
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- 2018
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41. Supplementary Table 1 from Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations
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Fehringer, Gordon, primary, Kraft, Peter, primary, Pharoah, Paul D., primary, Eeles, Rosalind A., primary, Chatterjee, Nilanjan, primary, Schumacher, Fredrick R., primary, Schildkraut, Joellen M., primary, Lindström, Sara, primary, Brennan, Paul, primary, Bickeböller, Heike, primary, Houlston, Richard S., primary, Landi, Maria Teresa, primary, Caporaso, Neil, primary, Risch, Angela, primary, Amin Al Olama, Ali, primary, Berndt, Sonja I., primary, Giovannucci, Edward L., primary, Grönberg, Henrik, primary, Kote-Jarai, Zsofia, primary, Ma, Jing, primary, Muir, Kenneth, primary, Stampfer, Meir J., primary, Stevens, Victoria L., primary, Wiklund, Fredrik, primary, Willett, Walter C., primary, Goode, Ellen L., primary, Permuth, Jennifer B., primary, Risch, Harvey A., primary, Reid, Brett M., primary, Bezieau, Stephane, primary, Brenner, Hermann, primary, Chan, Andrew T., primary, Chang-Claude, Jenny, primary, Hudson, Thomas J., primary, Kocarnik, Jonathan K., primary, Newcomb, Polly A., primary, Schoen, Robert E., primary, Slattery, Martha L., primary, White, Emily, primary, Adank, Muriel A., primary, Ahsan, Habibul, primary, Aittomäki, Kristiina, primary, Baglietto, Laura, primary, Blomquist, Carl, primary, Canzian, Federico, primary, Czene, Kamila, primary, dos-Santos-Silva, Isabel, primary, Eliassen, A. Heather, primary, Figueroa, Jonine D., primary, Flesch-Janys, Dieter, primary, Fletcher, Olivia, primary, Garcia-Closas, Montserrat, primary, Gaudet, Mia M., primary, Johnson, Nichola, primary, Hall, Per, primary, Hazra, Aditi, primary, Hein, Rebecca, primary, Hofman, Albert, primary, Hopper, John L., primary, Irwanto, Astrid, primary, Johansson, Mattias, primary, Kaaks, Rudolf, primary, Kibriya, Muhammad G., primary, Lichtner, Peter, primary, Liu, Jianjun, primary, Lund, Eiliv, primary, Makalic, Enes, primary, Meindl, Alfons, primary, Müller-Myhsok, Bertram, primary, Muranen, Taru A., primary, Nevanlinna, Heli, primary, Peeters, Petra H., primary, Peto, Julian, primary, Prentice, Ross L., primary, Rahman, Nazneen, primary, Sanchez, Maria Jose, primary, Schmidt, Daniel F., primary, Schmutzler, Rita K., primary, Southey, Melissa C., primary, Tamimi, Rulla, primary, Travis, Ruth C., primary, Turnbull, Clare, primary, Uitterlinden, Andre G., primary, Wang, Zhaoming, primary, Whittemore, Alice S., primary, Yang, Xiaohong R., primary, Zheng, Wei, primary, Buchanan, Daniel D., primary, Casey, Graham, primary, Conti, David V., primary, Edlund, Christopher K., primary, Gallinger, Steven, primary, Haile, Robert W., primary, Jenkins, Mark, primary, Le Marchand, Loïc, primary, Li, Li, primary, Lindor, Noralene M., primary, Schmit, Stephanie L., primary, Thibodeau, Stephen N., primary, Woods, Michael O., primary, Rafnar, Thorunn, primary, Gudmundsson, Julius, primary, Stacey, Simon N., primary, Stefansson, Kari, primary, Sulem, Patrick, primary, Chen, Y. Ann, primary, Tyrer, Jonathan P., primary, Christiani, David C., primary, Wei, Yongyue, primary, Shen, Hongbing, primary, Hu, Zhibin, primary, Shu, Xiao-Ou, primary, Shiraishi, Kouya, primary, Takahashi, Atsushi, primary, Bossé, Yohan, primary, Obeidat, Ma'en, primary, Nickle, David, primary, Timens, Wim, primary, Freedman, Matthew L., primary, Li, Qiyuan, primary, Seminara, Daniela, primary, Chanock, Stephen J., primary, Gong, Jian, primary, Peters, Ulrike, primary, Gruber, Stephen B., primary, Amos, Christopher I., primary, Sellers, Thomas A., primary, Easton, Douglas F., primary, Hunter, David J., primary, Haiman, Christopher A., primary, Henderson, Brian E., primary, and Hung, Rayjean J., primary
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- 2023
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42. Data from Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations
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Fehringer, Gordon, primary, Kraft, Peter, primary, Pharoah, Paul D., primary, Eeles, Rosalind A., primary, Chatterjee, Nilanjan, primary, Schumacher, Fredrick R., primary, Schildkraut, Joellen M., primary, Lindström, Sara, primary, Brennan, Paul, primary, Bickeböller, Heike, primary, Houlston, Richard S., primary, Landi, Maria Teresa, primary, Caporaso, Neil, primary, Risch, Angela, primary, Amin Al Olama, Ali, primary, Berndt, Sonja I., primary, Giovannucci, Edward L., primary, Grönberg, Henrik, primary, Kote-Jarai, Zsofia, primary, Ma, Jing, primary, Muir, Kenneth, primary, Stampfer, Meir J., primary, Stevens, Victoria L., primary, Wiklund, Fredrik, primary, Willett, Walter C., primary, Goode, Ellen L., primary, Permuth, Jennifer B., primary, Risch, Harvey A., primary, Reid, Brett M., primary, Bezieau, Stephane, primary, Brenner, Hermann, primary, Chan, Andrew T., primary, Chang-Claude, Jenny, primary, Hudson, Thomas J., primary, Kocarnik, Jonathan K., primary, Newcomb, Polly A., primary, Schoen, Robert E., primary, Slattery, Martha L., primary, White, Emily, primary, Adank, Muriel A., primary, Ahsan, Habibul, primary, Aittomäki, Kristiina, primary, Baglietto, Laura, primary, Blomquist, Carl, primary, Canzian, Federico, primary, Czene, Kamila, primary, dos-Santos-Silva, Isabel, primary, Eliassen, A. Heather, primary, Figueroa, Jonine D., primary, Flesch-Janys, Dieter, primary, Fletcher, Olivia, primary, Garcia-Closas, Montserrat, primary, Gaudet, Mia M., primary, Johnson, Nichola, primary, Hall, Per, primary, Hazra, Aditi, primary, Hein, Rebecca, primary, Hofman, Albert, primary, Hopper, John L., primary, Irwanto, Astrid, primary, Johansson, Mattias, primary, Kaaks, Rudolf, primary, Kibriya, Muhammad G., primary, Lichtner, Peter, primary, Liu, Jianjun, primary, Lund, Eiliv, primary, Makalic, Enes, primary, Meindl, Alfons, primary, Müller-Myhsok, Bertram, primary, Muranen, Taru A., primary, Nevanlinna, Heli, primary, Peeters, Petra H., primary, Peto, Julian, primary, Prentice, Ross L., primary, Rahman, Nazneen, primary, Sanchez, Maria Jose, primary, Schmidt, Daniel F., primary, Schmutzler, Rita K., primary, Southey, Melissa C., primary, Tamimi, Rulla, primary, Travis, Ruth C., primary, Turnbull, Clare, primary, Uitterlinden, Andre G., primary, Wang, Zhaoming, primary, Whittemore, Alice S., primary, Yang, Xiaohong R., primary, Zheng, Wei, primary, Buchanan, Daniel D., primary, Casey, Graham, primary, Conti, David V., primary, Edlund, Christopher K., primary, Gallinger, Steven, primary, Haile, Robert W., primary, Jenkins, Mark, primary, Le Marchand, Loïc, primary, Li, Li, primary, Lindor, Noralene M., primary, Schmit, Stephanie L., primary, Thibodeau, Stephen N., primary, Woods, Michael O., primary, Rafnar, Thorunn, primary, Gudmundsson, Julius, primary, Stacey, Simon N., primary, Stefansson, Kari, primary, Sulem, Patrick, primary, Chen, Y. Ann, primary, Tyrer, Jonathan P., primary, Christiani, David C., primary, Wei, Yongyue, primary, Shen, Hongbing, primary, Hu, Zhibin, primary, Shu, Xiao-Ou, primary, Shiraishi, Kouya, primary, Takahashi, Atsushi, primary, Bossé, Yohan, primary, Obeidat, Ma'en, primary, Nickle, David, primary, Timens, Wim, primary, Freedman, Matthew L., primary, Li, Qiyuan, primary, Seminara, Daniela, primary, Chanock, Stephen J., primary, Gong, Jian, primary, Peters, Ulrike, primary, Gruber, Stephen B., primary, Amos, Christopher I., primary, Sellers, Thomas A., primary, Easton, Douglas F., primary, Hunter, David J., primary, Haiman, Christopher A., primary, Henderson, Brian E., primary, and Hung, Rayjean J., primary
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- 2023
- Full Text
- View/download PDF
43. Supplementary Methods and Tables from The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers
- Author
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Amos, Christopher I., primary, Dennis, Joe, primary, Wang, Zhaoming, primary, Byun, Jinyoung, primary, Schumacher, Fredrick R., primary, Gayther, Simon A., primary, Casey, Graham, primary, Hunter, David J., primary, Sellers, Thomas A., primary, Gruber, Stephen B., primary, Dunning, Alison M., primary, Michailidou, Kyriaki, primary, Fachal, Laura, primary, Doheny, Kimberly, primary, Spurdle, Amanda B., primary, Li, Yafang, primary, Xiao, Xiangjun, primary, Romm, Jane, primary, Pugh, Elizabeth, primary, Coetzee, Gerhard A., primary, Hazelett, Dennis J., primary, Bojesen, Stig E., primary, Caga-Anan, Charlisse, primary, Haiman, Christopher A., primary, Kamal, Ahsan, primary, Luccarini, Craig, primary, Tessier, Daniel, primary, Vincent, Daniel, primary, Bacot, François, primary, Van Den Berg, David J., primary, Nelson, Stefanie, primary, Demetriades, Stephen, primary, Goldgar, David E., primary, Couch, Fergus J., primary, Forman, Judith L., primary, Giles, Graham G., primary, Conti, David V., primary, Bickeböller, Heike, primary, Risch, Angela, primary, Waldenberger, Melanie, primary, Brüske-Hohlfeld, Irene, primary, Hicks, Belynda D., primary, Ling, Hua, primary, McGuffog, Lesley, primary, Lee, Andrew, primary, Kuchenbaecker, Karoline, primary, Soucy, Penny, primary, Manz, Judith, primary, Cunningham, Julie M., primary, Butterbach, Katja, primary, Kote-Jarai, Zsofia, primary, Kraft, Peter, primary, FitzGerald, Liesel, primary, Lindström, Sara, primary, Adams, Marcia, primary, McKay, James D., primary, Phelan, Catherine M., primary, Benlloch, Sara, primary, Kelemen, Linda E., primary, Brennan, Paul, primary, Riggan, Marjorie, primary, O'Mara, Tracy A., primary, Shen, Hongbing, primary, Shi, Yongyong, primary, Thompson, Deborah J., primary, Goodman, Marc T., primary, Nielsen, Sune F., primary, Berchuck, Andrew, primary, Laboissiere, Sylvie, primary, Schmit, Stephanie L., primary, Shelford, Tameka, primary, Edlund, Christopher K., primary, Taylor, Jack A., primary, Field, John K., primary, Park, Sue K., primary, Offit, Kenneth, primary, Thomassen, Mads, primary, Schmutzler, Rita, primary, Ottini, Laura, primary, Hung, Rayjean J., primary, Marchini, Jonathan, primary, Amin Al Olama, Ali, primary, Peters, Ulrike, primary, Eeles, Rosalind A., primary, Seldin, Michael F., primary, Gillanders, Elizabeth, primary, Seminara, Daniela, primary, Antoniou, Antonis C., primary, Pharoah, Paul D.P., primary, Chenevix-Trench, Georgia, primary, Chanock, Stephen J., primary, Simard, Jacques, primary, and Easton, Douglas F., primary
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- 2023
- Full Text
- View/download PDF
44. Supplementary Table 2 and Supplemental Figures from Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations
- Author
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Fehringer, Gordon, primary, Kraft, Peter, primary, Pharoah, Paul D., primary, Eeles, Rosalind A., primary, Chatterjee, Nilanjan, primary, Schumacher, Fredrick R., primary, Schildkraut, Joellen M., primary, Lindström, Sara, primary, Brennan, Paul, primary, Bickeböller, Heike, primary, Houlston, Richard S., primary, Landi, Maria Teresa, primary, Caporaso, Neil, primary, Risch, Angela, primary, Amin Al Olama, Ali, primary, Berndt, Sonja I., primary, Giovannucci, Edward L., primary, Grönberg, Henrik, primary, Kote-Jarai, Zsofia, primary, Ma, Jing, primary, Muir, Kenneth, primary, Stampfer, Meir J., primary, Stevens, Victoria L., primary, Wiklund, Fredrik, primary, Willett, Walter C., primary, Goode, Ellen L., primary, Permuth, Jennifer B., primary, Risch, Harvey A., primary, Reid, Brett M., primary, Bezieau, Stephane, primary, Brenner, Hermann, primary, Chan, Andrew T., primary, Chang-Claude, Jenny, primary, Hudson, Thomas J., primary, Kocarnik, Jonathan K., primary, Newcomb, Polly A., primary, Schoen, Robert E., primary, Slattery, Martha L., primary, White, Emily, primary, Adank, Muriel A., primary, Ahsan, Habibul, primary, Aittomäki, Kristiina, primary, Baglietto, Laura, primary, Blomquist, Carl, primary, Canzian, Federico, primary, Czene, Kamila, primary, dos-Santos-Silva, Isabel, primary, Eliassen, A. Heather, primary, Figueroa, Jonine D., primary, Flesch-Janys, Dieter, primary, Fletcher, Olivia, primary, Garcia-Closas, Montserrat, primary, Gaudet, Mia M., primary, Johnson, Nichola, primary, Hall, Per, primary, Hazra, Aditi, primary, Hein, Rebecca, primary, Hofman, Albert, primary, Hopper, John L., primary, Irwanto, Astrid, primary, Johansson, Mattias, primary, Kaaks, Rudolf, primary, Kibriya, Muhammad G., primary, Lichtner, Peter, primary, Liu, Jianjun, primary, Lund, Eiliv, primary, Makalic, Enes, primary, Meindl, Alfons, primary, Müller-Myhsok, Bertram, primary, Muranen, Taru A., primary, Nevanlinna, Heli, primary, Peeters, Petra H., primary, Peto, Julian, primary, Prentice, Ross L., primary, Rahman, Nazneen, primary, Sanchez, Maria Jose, primary, Schmidt, Daniel F., primary, Schmutzler, Rita K., primary, Southey, Melissa C., primary, Tamimi, Rulla, primary, Travis, Ruth C., primary, Turnbull, Clare, primary, Uitterlinden, Andre G., primary, Wang, Zhaoming, primary, Whittemore, Alice S., primary, Yang, Xiaohong R., primary, Zheng, Wei, primary, Buchanan, Daniel D., primary, Casey, Graham, primary, Conti, David V., primary, Edlund, Christopher K., primary, Gallinger, Steven, primary, Haile, Robert W., primary, Jenkins, Mark, primary, Le Marchand, Loïc, primary, Li, Li, primary, Lindor, Noralene M., primary, Schmit, Stephanie L., primary, Thibodeau, Stephen N., primary, Woods, Michael O., primary, Rafnar, Thorunn, primary, Gudmundsson, Julius, primary, Stacey, Simon N., primary, Stefansson, Kari, primary, Sulem, Patrick, primary, Chen, Y. Ann, primary, Tyrer, Jonathan P., primary, Christiani, David C., primary, Wei, Yongyue, primary, Shen, Hongbing, primary, Hu, Zhibin, primary, Shu, Xiao-Ou, primary, Shiraishi, Kouya, primary, Takahashi, Atsushi, primary, Bossé, Yohan, primary, Obeidat, Ma'en, primary, Nickle, David, primary, Timens, Wim, primary, Freedman, Matthew L., primary, Li, Qiyuan, primary, Seminara, Daniela, primary, Chanock, Stephen J., primary, Gong, Jian, primary, Peters, Ulrike, primary, Gruber, Stephen B., primary, Amos, Christopher I., primary, Sellers, Thomas A., primary, Easton, Douglas F., primary, Hunter, David J., primary, Haiman, Christopher A., primary, Henderson, Brian E., primary, and Hung, Rayjean J., primary
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- 2023
- Full Text
- View/download PDF
45. Data from Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk
- Author
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Patel, Yesha M., primary, Park, Sunghim L., primary, Han, Younghun, primary, Wilkens, Lynne R., primary, Bickeböller, Heike, primary, Rosenberger, Albert, primary, Caporaso, Neil, primary, Landi, Maria Teresa, primary, Brüske, Irene, primary, Risch, Angela, primary, Wei, Yongyue, primary, Christiani, David C., primary, Brennan, Paul, primary, Houlston, Richard, primary, McKay, James, primary, McLaughlin, John, primary, Hung, Rayjean, primary, Murphy, Sharon, primary, Stram, Daniel O., primary, Amos, Christopher, primary, and Le Marchand, Loïc, primary
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- 2023
- Full Text
- View/download PDF
46. Supplemental Table 5 from Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk
- Author
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Patel, Yesha M., primary, Park, Sunghim L., primary, Han, Younghun, primary, Wilkens, Lynne R., primary, Bickeböller, Heike, primary, Rosenberger, Albert, primary, Caporaso, Neil, primary, Landi, Maria Teresa, primary, Brüske, Irene, primary, Risch, Angela, primary, Wei, Yongyue, primary, Christiani, David C., primary, Brennan, Paul, primary, Houlston, Richard, primary, McKay, James, primary, McLaughlin, John, primary, Hung, Rayjean, primary, Murphy, Sharon, primary, Stram, Daniel O., primary, Amos, Christopher, primary, and Le Marchand, Loïc, primary
- Published
- 2023
- Full Text
- View/download PDF
47. Supplementary Information from Assessing Lung Cancer Absolute Risk Trajectory Based on a Polygenic Risk Model
- Author
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Hung, Rayjean J., primary, Warkentin, Matthew T., primary, Brhane, Yonathan, primary, Chatterjee, Nilanjan, primary, Christiani, David C., primary, Landi, Maria Teresa, primary, Caporaso, Neil E., primary, Liu, Geoffrey, primary, Johansson, Mattias, primary, Albanes, Demetrius, primary, Marchand, Loic Le, primary, Tardon, Adonina, primary, Rennert, Gad, primary, Bojesen, Stig E., primary, Chen, Chu, primary, Field, John K., primary, Kiemeney, Lambertus A., primary, Lazarus, Philip, primary, Zienolddiny, Shanbeth, primary, Lam, Stephen, primary, Andrew, Angeline S., primary, Arnold, Susanne M., primary, Aldrich, Melinda C., primary, Bickeböller, Heike, primary, Risch, Angela, primary, Schabath, Matthew B., primary, McKay, James D., primary, Brennan, Paul, primary, and Amos, Christopher I., primary
- Published
- 2023
- Full Text
- View/download PDF
48. Data from Assessing Lung Cancer Absolute Risk Trajectory Based on a Polygenic Risk Model
- Author
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Hung, Rayjean J., primary, Warkentin, Matthew T., primary, Brhane, Yonathan, primary, Chatterjee, Nilanjan, primary, Christiani, David C., primary, Landi, Maria Teresa, primary, Caporaso, Neil E., primary, Liu, Geoffrey, primary, Johansson, Mattias, primary, Albanes, Demetrius, primary, Marchand, Loic Le, primary, Tardon, Adonina, primary, Rennert, Gad, primary, Bojesen, Stig E., primary, Chen, Chu, primary, Field, John K., primary, Kiemeney, Lambertus A., primary, Lazarus, Philip, primary, Zienolddiny, Shanbeth, primary, Lam, Stephen, primary, Andrew, Angeline S., primary, Arnold, Susanne M., primary, Aldrich, Melinda C., primary, Bickeböller, Heike, primary, Risch, Angela, primary, Schabath, Matthew B., primary, McKay, James D., primary, Brennan, Paul, primary, and Amos, Christopher I., primary
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- 2023
- Full Text
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49. Supplementary Material: Funding, Acknowledgements, Consortia, and Bioinformatics Tools Funding sources from Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations
- Author
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Fehringer, Gordon, primary, Kraft, Peter, primary, Pharoah, Paul D., primary, Eeles, Rosalind A., primary, Chatterjee, Nilanjan, primary, Schumacher, Fredrick R., primary, Schildkraut, Joellen M., primary, Lindström, Sara, primary, Brennan, Paul, primary, Bickeböller, Heike, primary, Houlston, Richard S., primary, Landi, Maria Teresa, primary, Caporaso, Neil, primary, Risch, Angela, primary, Amin Al Olama, Ali, primary, Berndt, Sonja I., primary, Giovannucci, Edward L., primary, Grönberg, Henrik, primary, Kote-Jarai, Zsofia, primary, Ma, Jing, primary, Muir, Kenneth, primary, Stampfer, Meir J., primary, Stevens, Victoria L., primary, Wiklund, Fredrik, primary, Willett, Walter C., primary, Goode, Ellen L., primary, Permuth, Jennifer B., primary, Risch, Harvey A., primary, Reid, Brett M., primary, Bezieau, Stephane, primary, Brenner, Hermann, primary, Chan, Andrew T., primary, Chang-Claude, Jenny, primary, Hudson, Thomas J., primary, Kocarnik, Jonathan K., primary, Newcomb, Polly A., primary, Schoen, Robert E., primary, Slattery, Martha L., primary, White, Emily, primary, Adank, Muriel A., primary, Ahsan, Habibul, primary, Aittomäki, Kristiina, primary, Baglietto, Laura, primary, Blomquist, Carl, primary, Canzian, Federico, primary, Czene, Kamila, primary, dos-Santos-Silva, Isabel, primary, Eliassen, A. Heather, primary, Figueroa, Jonine D., primary, Flesch-Janys, Dieter, primary, Fletcher, Olivia, primary, Garcia-Closas, Montserrat, primary, Gaudet, Mia M., primary, Johnson, Nichola, primary, Hall, Per, primary, Hazra, Aditi, primary, Hein, Rebecca, primary, Hofman, Albert, primary, Hopper, John L., primary, Irwanto, Astrid, primary, Johansson, Mattias, primary, Kaaks, Rudolf, primary, Kibriya, Muhammad G., primary, Lichtner, Peter, primary, Liu, Jianjun, primary, Lund, Eiliv, primary, Makalic, Enes, primary, Meindl, Alfons, primary, Müller-Myhsok, Bertram, primary, Muranen, Taru A., primary, Nevanlinna, Heli, primary, Peeters, Petra H., primary, Peto, Julian, primary, Prentice, Ross L., primary, Rahman, Nazneen, primary, Sanchez, Maria Jose, primary, Schmidt, Daniel F., primary, Schmutzler, Rita K., primary, Southey, Melissa C., primary, Tamimi, Rulla, primary, Travis, Ruth C., primary, Turnbull, Clare, primary, Uitterlinden, Andre G., primary, Wang, Zhaoming, primary, Whittemore, Alice S., primary, Yang, Xiaohong R., primary, Zheng, Wei, primary, Buchanan, Daniel D., primary, Casey, Graham, primary, Conti, David V., primary, Edlund, Christopher K., primary, Gallinger, Steven, primary, Haile, Robert W., primary, Jenkins, Mark, primary, Le Marchand, Loïc, primary, Li, Li, primary, Lindor, Noralene M., primary, Schmit, Stephanie L., primary, Thibodeau, Stephen N., primary, Woods, Michael O., primary, Rafnar, Thorunn, primary, Gudmundsson, Julius, primary, Stacey, Simon N., primary, Stefansson, Kari, primary, Sulem, Patrick, primary, Chen, Y. Ann, primary, Tyrer, Jonathan P., primary, Christiani, David C., primary, Wei, Yongyue, primary, Shen, Hongbing, primary, Hu, Zhibin, primary, Shu, Xiao-Ou, primary, Shiraishi, Kouya, primary, Takahashi, Atsushi, primary, Bossé, Yohan, primary, Obeidat, Ma'en, primary, Nickle, David, primary, Timens, Wim, primary, Freedman, Matthew L., primary, Li, Qiyuan, primary, Seminara, Daniela, primary, Chanock, Stephen J., primary, Gong, Jian, primary, Peters, Ulrike, primary, Gruber, Stephen B., primary, Amos, Christopher I., primary, Sellers, Thomas A., primary, Easton, Douglas F., primary, Hunter, David J., primary, Haiman, Christopher A., primary, Henderson, Brian E., primary, and Hung, Rayjean J., primary
- Published
- 2023
- Full Text
- View/download PDF
50. Supplemental Table 3 from Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk
- Author
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Patel, Yesha M., primary, Park, Sunghim L., primary, Han, Younghun, primary, Wilkens, Lynne R., primary, Bickeböller, Heike, primary, Rosenberger, Albert, primary, Caporaso, Neil, primary, Landi, Maria Teresa, primary, Brüske, Irene, primary, Risch, Angela, primary, Wei, Yongyue, primary, Christiani, David C., primary, Brennan, Paul, primary, Houlston, Richard, primary, McKay, James, primary, McLaughlin, John, primary, Hung, Rayjean, primary, Murphy, Sharon, primary, Stram, Daniel O., primary, Amos, Christopher, primary, and Le Marchand, Loïc, primary
- Published
- 2023
- Full Text
- View/download PDF
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