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1,213 results on '"Bianchi, Anna"'

3. Topological Data Analysis of Resting-State fMRI Suggests Altered Brain Network Topology in Functional Dyspepsia: A Mapper-Based Parcellation Approach

Author

Tassi, Emma, Fisher, Harrison, Bolender, Andrew, Lee, Jun-Hwan, Ayoub, Lizbeth J., Bianchi, Anna Maria, Kuo, Braden, Napadow, Vitaly, Maggioni, Eleonora, Sclocco, Roberta, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Chen, Chao, editor, Singh, Yash, editor, and Hu, Xiaoling, editor

Published
2025
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6. Cell-Autonomous Cxcl1 Sustains Tolerogenic Circuitries and Stromal Inflammation via Neutrophil-Derived TNF in Pancreatic Cancer.

Author

Bianchi, Anna, De Castro Silva, Iago, Deshpande, Nilesh, Singh, Samara, Mehra, Siddharth, Garrido, Vanessa, Guo, Xinyu, Nivelo, Luis, Kolonias, Despina, Saigh, Shannon, Wieder, Eric, Rafie, Christine, Dosch, Austin, Zhou, Zhiqun, Umland, Oliver, Amirian, Haleh, Ogobuiro, Ifeanyichukwu, Zhang, Jian, Ban, Yuguang, Shiau, Carina, Nagathihalli, Nagaraj, Montgomery, Elizabeth, Hwang, William, Brambilla, Roberta, Villarino, Alejandro, Toska, Eneda, Stanger, Ben, Gabrilovich, Dmitry, Merchant, Nipun, Datta, Jashodeep, and Komanduri, Krishna

Subjects
Humans, Neutrophils, Receptors, Tumor Necrosis Factor, Type II, Proto-Oncogene Proteins p21(ras), Pancreatic Neoplasms, Carcinoma, Pancreatic Ductal, Inflammation, Tumor Microenvironment, Chemokine CXCL1
Abstract

UNLABELLED: We have shown that KRAS-TP53 genomic coalteration is associated with immune-excluded microenvironments, chemoresistance, and poor survival in pancreatic ductal adenocarcinoma (PDAC) patients. By treating KRAS-TP53 cooperativity as a model for high-risk biology, we now identify cell-autonomous Cxcl1 as a key mediator of spatial T-cell restriction via interactions with CXCR2+ neutrophilic myeloid-derived suppressor cells in human PDAC using imaging mass cytometry. Silencing of cell-intrinsic Cxcl1 in LSL-KrasG12D/+;Trp53R172H/+;Pdx-1Cre/+(KPC) cells reprograms the trafficking and functional dynamics of neutrophils to overcome T-cell exclusion and controls tumor growth in a T cell-dependent manner. Mechanistically, neutrophil-derived TNF is a central regulator of this immunologic rewiring, instigating feed-forward Cxcl1 overproduction from tumor cells and cancer-associated fibroblasts (CAF), T-cell dysfunction, and inflammatory CAF polarization via transmembrane TNF-TNFR2 interactions. TNFR2 inhibition disrupts this circuitry and improves sensitivity to chemotherapy in vivo. Our results uncover cancer cell-neutrophil cross-talk in which context-dependent TNF signaling amplifies stromal inflammation and immune tolerance to promote therapeutic resistance in PDAC. SIGNIFICANCE: By decoding connections between high-risk tumor genotypes, cell-autonomous inflammatory programs, and myeloid-enriched/T cell-excluded contexts, we identify a novel role for neutrophil-derived TNF in sustaining immunosuppression and stromal inflammation in pancreatic tumor microenvironments. This work offers a conceptual framework by which targeting context-dependent TNF signaling may overcome hallmarks of chemoresistance in pancreatic cancer. This article is highlighted in the In This Issue feature, p. 1275.

Published
2023

7. Association Between Variations in Kinematic Indexes of Manual Dexterity and Mu Rhythm Desynchronization Changes After Action Observation and Motor Imagery

Author

Temporiti, Federico, Calcagno, Alessandra, Coelli, Stefania, Marino, Giorgia, Gatti, Roberto, Bianchi, Anna Maria, Galli, Manuela, Magjarević, Ratko, Series Editor, Ładyżyński, Piotr, Associate Editor, Ibrahim, Fatimah, Associate Editor, Lackovic, Igor, Associate Editor, Rock, Emilio Sacristan, Associate Editor, Badnjević, Almir, editor, and Gurbeta Pokvić, Lejla, editor

Published
2024
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8. Handedness-Dependent Brain Networks Re-organization During Visuo-Motor Task Execution

Author

Calcagno, Alessandra, Coelli, Stefania, Temporiti, Federico, Gatti, Roberto, Galli, Manuela, Bianchi, Anna Maria, Magjarević, Ratko, Series Editor, Ładyżyński, Piotr, Associate Editor, Ibrahim, Fatimah, Associate Editor, Lackovic, Igor, Associate Editor, Rock, Emilio Sacristan, Associate Editor, Badnjević, Almir, editor, and Gurbeta Pokvić, Lejla, editor

Published
2024
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9. Multi-Scale Assessment of Harmonization Efficacy on Resting-State Functional Connectivity

Author

Tassi, Emma, Goffi, Federica, Rossetti, Maria Gloria, Bellani, Marcella, Vai, Benedetta, Calesella, Federico, Benedetti, Francesco, Bianchi, Anna Maria, Brambilla, Paolo, Maggioni, Eleonora, Magjarević, Ratko, Series Editor, Ładyżyński, Piotr, Associate Editor, Ibrahim, Fatimah, Associate Editor, Lackovic, Igor, Associate Editor, Rock, Emilio Sacristan, Associate Editor, Badnjević, Almir, editor, and Gurbeta Pokvić, Lejla, editor

Published
2024
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10. A TMS-EEG Pre-processing Parameters Tuning Study

Author

Bondi, Elena, Pescuma, Viviana, Massalha, Yara, Pizzolante, Marta, Chirico, Alice, Schiena, Giandomenico, Bianchi, Anna Maria, Brambilla, Paolo, Maggioni, Eleonora, Magjarević, Ratko, Series Editor, Ładyżyński, Piotr, Associate Editor, Ibrahim, Fatimah, Associate Editor, Lackovic, Igor, Associate Editor, Rock, Emilio Sacristan, Associate Editor, Badnjević, Almir, editor, and Gurbeta Pokvić, Lejla, editor

Published
2024
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21. Quantitative susceptibility mapping of the normal-appearing white matter as a potential new marker of disability progression in multiple sclerosis

Author

Pietroboni, Anna M., Colombi, Annalisa, Contarino, Valeria E., Russo, Francesco Maria Lo, Conte, Giorgio, Morabito, Aurelia, Siggillino, Silvia, Carandini, Tiziana, Fenoglio, Chiara, Arighi, Andrea, De Riz, Milena A., Arcaro, Marina, Sacchi, Luca, Fumagalli, Giorgio G., Bianchi, Anna Maria, Triulzi, Fabio, Scarpini, Elio, and Galimberti, Daniela

Published
2023
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22. Magnetic susceptibility as a 1-year predictor of outcome in familial cerebral cavernous malformations: a pilot study

Author

Incerti, Irene, Fusco, Massimo, Contarino, Valeria Elisa, Siggillino, Silvia, Conte, Giorgio, Lanfranconi, Silvia, Bertani, Giulio Andrea, Gaudino, Chiara, d’Orio, Piergiorgio, Pallini, Roberto, D’Alessandris, Quintino Giorgio, Meessen, Jennifer Marie Theresia Anna, Nicolis, Enrico Bjorn, Vasamì, Antonella, Dejana, Elisabetta, Bianchi, Anna Maria, Triulzi, Fabio Maria, Latini, Roberto, and Scola, Elisa

Published
2023
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24. Multiscale-Multifractal Assessment of Heart Rate Variability in Shift Workers by Detrended Fluctuation Analysis

Author

Delgado-Aranda, Raquel, Dorantes-Méndez, Guadalupe, Méndez, Martín Oswaldo, Bianchi, Anna Maria, Kortelainen, Juha, Magjarevic, Ratko, Series Editor, Ładyżyński, Piotr, Associate Editor, Ibrahim, Fatimah, Associate Editor, Lackovic, Igor, Associate Editor, Rock, Emilio Sacristan, Associate Editor, Trujillo-Romero, Citlalli Jessica, editor, Gonzalez-Landaeta, Rafael, editor, Chapa-González, Christian, editor, Dorantes-Méndez, Guadalupe, editor, Flores, Dora-Luz, editor, Flores Cuautle, J. J. Agustin, editor, Ortiz-Posadas, Martha R., editor, Salido Ruiz, Ricardo A., editor, and Zuñiga-Aguilar, Esmeralda, editor

Published
2023
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32. Distinct mechanisms of innate and adaptive immune regulation underlie poor oncologic outcomes associated with KRAS-TP53 co-alteration in pancreatic cancer

Author

Datta, Jashodeep, Bianchi, Anna, De Castro Silva, Iago, Deshpande, Nilesh U., Cao, Long Long, Mehra, Siddharth, Singh, Samara, Rafie, Christine, Sun, Xiaodian, Chen, Xi, Dai, Xizi, Colaprico, Antonio, Sharma, Prateek, Dosch, Austin R., Pillai, Asha, Hosein, Peter J., Nagathihalli, Nagaraj S., Komanduri, Krishna V., Wilson, Julie M., Ban, Yuguang, and Merchant, Nipun B.

Published
2022
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38. Sea Farms as a Safe and Sustainable Food Source: An Investigation on Use of Seaweeds for Liver Detoxification and Reduced DNA Damage in Lates Calcarifer (Bloch, 1790)

Author

Olanrewaju, Oladokun Sulaiman, De Maio, Anna, Lionetti, Eva, Bianchi, Anna Rita, Rabbito, Dea, Ariano, Andrea, Majdoubi, Fatima-Zahra, Guerriero, Giulia, Förstner, Ulrich, Series Editor, Rulkens, Wim H., Series Editor, Salomons, Wim, Series Editor, Ksibi, Mohamed, editor, Ghorbal, Achraf, editor, Chakraborty, Sudip, editor, Chaminé, Helder I., editor, Barbieri, Maurizio, editor, Guerriero, Giulia, editor, Hentati, Olfa, editor, Negm, Abdelazim, editor, Lehmann, Anthony, editor, Römbke, Jörg, editor, Costa Duarte, Armando, editor, Xoplaki, Elena, editor, Khélifi, Nabil, editor, Colinet, Gilles, editor, Miguel Dias, João, editor, Gargouri, Imed, editor, Van Hullebusch, Eric D., editor, Sánchez Cabrero, Benigno, editor, Ferlisi, Settimio, editor, Tizaoui, Chedly, editor, Kallel, Amjad, editor, Rtimi, Sami, editor, Panda, Sandeep, editor, Michaud, Philippe, editor, Sahu, Jaya Narayana, editor, Seffen, Mongi, editor, and Naddeo, Vincenzo, editor

Published
2021
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41. Supplementary Figure S6 from Tumor Cell–Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer

Author

Singh, Samara P., primary, Dosch, Austin R., primary, Mehra, Siddharth, primary, De Castro Silva, Iago, primary, Bianchi, Anna, primary, Garrido, Vanessa T., primary, Zhou, Zhiqun, primary, Adams, Andrew, primary, Amirian, Haleh, primary, Box, Edmond W., primary, Sun, Xiaodian, primary, Ban, Yuguang, primary, Datta, Jashodeep, primary, Nagathihalli, Nagaraj S., primary, and Merchant, Nipun B., primary

Published
2024
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42. Supplementary Data from Tumor Cell–Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer

Author

Singh, Samara P., primary, Dosch, Austin R., primary, Mehra, Siddharth, primary, De Castro Silva, Iago, primary, Bianchi, Anna, primary, Garrido, Vanessa T., primary, Zhou, Zhiqun, primary, Adams, Andrew, primary, Amirian, Haleh, primary, Box, Edmond W., primary, Sun, Xiaodian, primary, Ban, Yuguang, primary, Datta, Jashodeep, primary, Nagathihalli, Nagaraj S., primary, and Merchant, Nipun B., primary

Published
2024
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43. Supplementary Materials and Methods from Tumor Cell–Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer

Author

Singh, Samara P., primary, Dosch, Austin R., primary, Mehra, Siddharth, primary, De Castro Silva, Iago, primary, Bianchi, Anna, primary, Garrido, Vanessa T., primary, Zhou, Zhiqun, primary, Adams, Andrew, primary, Amirian, Haleh, primary, Box, Edmond W., primary, Sun, Xiaodian, primary, Ban, Yuguang, primary, Datta, Jashodeep, primary, Nagathihalli, Nagaraj S., primary, and Merchant, Nipun B., primary

Published
2024
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44. Supplementary Figure Legends from Tumor Cell–Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer

Author

Singh, Samara P., primary, Dosch, Austin R., primary, Mehra, Siddharth, primary, De Castro Silva, Iago, primary, Bianchi, Anna, primary, Garrido, Vanessa T., primary, Zhou, Zhiqun, primary, Adams, Andrew, primary, Amirian, Haleh, primary, Box, Edmond W., primary, Sun, Xiaodian, primary, Ban, Yuguang, primary, Datta, Jashodeep, primary, Nagathihalli, Nagaraj S., primary, and Merchant, Nipun B., primary

Published
2024
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45. Data from Tumor Cell–Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer

Author

Singh, Samara P., primary, Dosch, Austin R., primary, Mehra, Siddharth, primary, De Castro Silva, Iago, primary, Bianchi, Anna, primary, Garrido, Vanessa T., primary, Zhou, Zhiqun, primary, Adams, Andrew, primary, Amirian, Haleh, primary, Box, Edmond W., primary, Sun, Xiaodian, primary, Ban, Yuguang, primary, Datta, Jashodeep, primary, Nagathihalli, Nagaraj S., primary, and Merchant, Nipun B., primary

Published
2024
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47. ARTE Project: EEG Analysis During Robotic Rehabilitation

Author

Calcagno, Alessandra, Coelli, Stefania, Tacchino, Giulia, Baratto, Marta, Molteni, Franco, Guanziroli, Eleonora, Puttilli, Cosimo, Bianchi, Anna Maria, Magjarevic, Ratko, Series Editor, Ładyżyński, Piotr, Associate Editor, Ibrahim, Fatimah, Associate Editor, Lackovic, Igor, Associate Editor, Rock, Emilio Sacristan, Associate Editor, Henriques, Jorge, editor, Neves, Nuno, editor, and de Carvalho, Paulo, editor

Published
2020
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48. Central Alpha Bicoherence Is Reduced in Photosensitive Subjects

Author

Coelli, Stefania, Visani, Elisa, Tacchino, Giulia, Panzica, Ferruccio, Franceschetti, Silvana, Bianchi, Anna Maria, Magjarevic, Ratko, Series Editor, Ładyżyński, Piotr, Associate Editor, Ibrahim, Fatimah, Associate Editor, Lackovic, Igor, Associate Editor, Rock, Emilio Sacristan, Associate Editor, Henriques, Jorge, editor, Neves, Nuno, editor, and de Carvalho, Paulo, editor

Published
2020
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49. Preprocessing Pipeline for fNIRS Data in Children

Author

Piazza, Caterina, Bacchetta, Andrea, Crippa, Alessandro, Mauri, Maddalena, Grazioli, Silvia, Reni, Gianluigi, Nobile, Maria, Bianchi, Anna Maria, Magjarevic, Ratko, Series Editor, Ładyżyński, Piotr, Associate Editor, Ibrahim, Fatimah, Associate Editor, Lackovic, Igor, Associate Editor, Rock, Emilio Sacristan, Associate Editor, Henriques, Jorge, editor, Neves, Nuno, editor, and de Carvalho, Paulo, editor

Published
2020
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50. Efficacy of Time- and Frequency-Domain Heart Rate Variability Features in Stress Detection and Their Relation with Coping Strategies

Author

Reali, Pierluigi, Brugnera, Agostino, Compare, Angelo, Bianchi, Anna Maria, Magjarevic, Ratko, Series Editor, Ładyżyński, Piotr, Associate Editor, Ibrahim, Fatimah, Associate Editor, Lackovic, Igor, Associate Editor, Rock, Emilio Sacristan, Associate Editor, Henriques, Jorge, editor, Neves, Nuno, editor, and de Carvalho, Paulo, editor

Published
2020
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