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Yong Liu,1 Hui Liu,2 Queqiao Bian,1 Shuhuan Zhang,1 Yanmin Guan3 1Department of Dermatology & STD, The Third Central Hospital of Tianjin; Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases; Artificial Cell Engineering Technology Research Center; Tianjin Institute of Hepatobiliary Disease, Tianjin, People’s Republic of China; 2Tianjin Institute of Hepatobiliary Disease, The Third Central Hospital of Tianjin, Tianjin, People’s Republic of China; 3Department of Tuberculosis, Tianjin Haihe Hospital, Tianjin, People’s Republic of ChinaCorrespondence: Yong Liu, Department of Dermatology & STD, The Third Central Hospital of Tianjin; Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases; Artificial Cell Engineering Technology Research Center; Tianjin Institute of Hepatobiliary Disease, No. 83, Jintang Road, Hedong District, Tianjin, 300170, People’s Republic of China, Email liuyongtj@163.comBackground: Herpes zoster (HZ) and postherpetic neuralgia (PHN) significantly affect patients’ quality of life (QoL). Cultural differences may lead to different patient-reported outcomes across countries. The current study aims to evaluate the detrimental impact of HZ and PHN on QoL in China.Methods: This prospective study was conducted from January 2020 to April 2023. We used the Zoster Brief Pain Inventory (ZBPI) and 5-level EuroQol-5 Dimension (EQ-5D-5L) questionnaire to assess the QoL of HZ and PHN patients. Patients were required to complete the questionnaires at 15, 30, 60, and 90 days after the onset of the HZ rash. Additional questionnaires were administered at 120, 150, and 180 days for those who developed PHN within three months of the rash’s onset.Results: A cohort of 633 patients with a median age of 63 years were included in the study. The mean delay from the appearance of the initial HZ rash to the first medical consultation was 5.1 ± 2.8 days. Approximately 30% of the HZ patients (189/633) went on to develop PHN. For patients with HZ who did not progress to PHN, the ZBPI worst pain score and impaired QoL had nearly resolved by day 90 post-rash onset. Conversely, there was no significant improvement in the ZBPI worst pain score and QoL for those with PHN, even by day 180 post-rash onset.Conclusion: Both HZ and PHN significantly impaired patients’ QoL. However, the impairment caused by PHN was more severe in both intensity and duration.Keywords: herpes zoster, pain, post-herpetic neuralgia, quality of life

Yong Liu,1 Hui Liu,2 Queqiao Bian,1 Shuhuan Zhang,1 Yanmin Guan3 1Department of Dermatology & STD, the Third Central Hospital of Tianjin; Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases; Artificial Cell Engineering Technology Research Center, Tianjin Institute of Hepatobiliary Disease, Tianjin, People’s Republic of China; 2Tianjin Institute of Hepatobiliary Disease, Tianjin, People’s Republic of China; 3Department of Tuberculosis, Tianjin Haihe Hospital, Tianjin, People’s Republic of ChinaCorrespondence: Yong Liu, Department of Dermatology & STD, the Third Central Hospital of Tianjin, No. 83, Jintang Road, Hedong District, Tianjin, 300170, People’s Republic of China, Tel +8602284112488, Email liuyongtj@163.comBackground: Herpes zoster (HZ) typically manifests in the acute phase with distinct blisters and severe neuropathic pain. Remarkably, a subset of patients initially presents with only a mild skin rash and moderate pain that gradually intensifies, following a parabolic pattern. Despite being frequently observed in clinical settings, the underlying causes of this trajectory and its potential connection with post-herpetic neuralgia (PHN) remain unclear.Methods: To investigate this phenomenon in-depth, we conducted a meticulous retrospective study involving 529 eligible HZ patients. All these patients sought medical care at the Third Central Hospital of Tianjin, China, between January 2020 and December 2023.Results: The research identified that 14.6% of the sample (77 patients) experienced pain scores aligning with a parabolic curve. This trend was significantly more prevalent in patients aged 60 and above, accounting for 90.9% of this group, and demonstrated a positive correlation with age. Moreover, 87.0% of these patients had pre-existing medical conditions, highlighting the potential role of comorbidities in influencing the pain trajectory. A concerning 45.5% of patients sought medical attention more than seven days after the onset of symptoms, a delay that could exacerbate neurological damage. Notably, among those following a parabolic pain pattern, 66.2% eventually developed PHN, a considerably higher rate compared to the broader patient population.Conclusion: We emphasize that healthcare practitioners meticulously assess patients who initially report lower pain scores for high-risk factors potentially leading to parabolic pain increases, including being over 60 years old, having comorbid conditions, and delaying medical consultation beyond seven days from symptom onset. Early implementation of supplementary pain management therapies may mitigate the risk of PHN development and enhance the quality of life for patients. This study furnishes clinicians with a deeper understanding of the variations in HZ-related pain trajectories, promising to improve treatment approaches and prognoses for HZ patients while paving the way for enriched clinical practice in the future.Keywords: parabolic pain trajectory, herpes zoster, post-herpetic neuralgia, delayed-onset pain, adjunctive analgesics, early intervention strategies

Jing Mao,1,* Ya Li,2– 4,* Qingqing Bian,3 Yinshuang Xuan,3 Jingmei Li,3 Zhikun Wang,3 Suxiang Feng,1,2,4 Xuefang Liu,2,4 Yange Tian,2,4 Suyun Li2– 4 1College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, People’s Republic of China; 2Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Zhengzhou, People’s Republic of China; 3Institute for Respiratory Diseases, The First Affiliated Hospital, Henan University of Chinese Medicine, Zhengzhou, People’s Republic of China; 4Co-Construction Collaborative Innovation Center for Chinese Medicine and Respiratory Disease by Henan & Education Ministry of P.R. China, Henan University of Chinese Medicine, Zhengzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Suyun Li, Email lisuyun2000@126.comPurpose: Bufei Jianpi formula (BJF), a traditional Chinese medicine, is an effective and safe therapeutic formula for chronic obstructive pulmonary disease (COPD). BJF treatment is known to reduce the incidence of loose stools in rats with COPD. It is unclear whether BJF regulates gut microbiota. This study examined whether BJF improved mucosal immune function by remodeling the gut microbiota and modulating metabolites in COPD rats.Methods: Sixty Sprague Dawley (SD) rats were randomized into control, model, BJF, aminophylline (APL), and probiotics (PBT) groups. The stable COPD rat model was duplicated using repeated cigarette smoke inhalation and lipopolysaccharide (LPS) injection. Normal saline, BJF, APL, or PBT were intragastrically administered from weeks eight to twelve, and then the rats were sacrificed at week thirteen. Lung and colon tissues were removed; feces were collected. Pulmonary function, histopathology, levels of inflammatory factors, and activation of NF-κB in the lung tissues were evaluated. Gut microbiota were analyzed using 16S rRNA gene sequencing; fecal short-chain fatty acid (SCFA) concentrations were determined using gas chromatography/mass spectrometry. Mucosal immune response-related genes and proteins were determined using quantitative polymerase chain reaction and Western blotting.Results: BJF improved pulmonary function and reduced lung inflammation. Further, BJF treatment altered the gut microbiota composition and significantly increased the abundance of Firmicutes and the ratio of Firmicutes to Bacteroides, raising SCFA levels, including acetate, butyrate, and propionate levels. However, the abundance of Bacteroidetes, Proteobacteria, Spirochaetes, Clostridiaceae, and Treponema decreased after BJF administration. BJF decreased the gene and protein expression of NLRP3, Caspase-1, IL-8, and IL-1β, and increased GPR43 expression.Conclusion: Overall, BJF administration improved mucosal immune function by remodeling the gut microbiota and suppressing the SCFAs/GPR43/NLRP3 pathway in COPD rats. This study provides evidence for the mechanisms underlying BJF-induced improvements in COPD and supports clinical application of BJF.Keywords: Bufei Jianpi formula, chronic obstructive pulmonary disease, gut microbiota, gut-lung axis, short-chain fatty acids, mucosal immune function

Yanhong Liu,1,2 Jingxu Chen,1,2 Lvzhen Huang,3 Shaoxiao Yan,1,2 Qingtao Bian,1,2 Fude Yang1,2 1Huilongguan Clinical Medical School, Peking University, Beijing, People’s Republic of China; 2Beijing Huilongguan Hospital, Beijing, People’s Republic of China; 3Ophthalmology Department, People’s Hospital of Peking University, Beijing, People’s Republic of ChinaCorrespondence: Fude YangHuilongguan Clinical Medical School, Peking University, Nandian, Road, Changping District, Beijing, 100096, People’s Republic of ChinaTel +86-10-83024251Fax +86-10-83024302Email yangfd2021@163.comBackground: Studies have suggested retinal nerve fiber layer (RNFL) involvement in the pathogenesis of schizophrenia. Additionally, research has shown that vascular endothelial growth factor (VEGF) potentially contributes to the pathophysiology of psychiatric disorders. Therefore, this study aimed to investigate VEGF, RNFL, and correlations with cognitive impairments in schizophrenia patients.Methods: Patients with schizophrenia (n = 138) were compared to healthy controls (n = 160). RNFLs were measured with optical coherence tomography (OCT). The Stroop color and word test (SCWT) was used to evaluate neurocognition. Blood samples were collected to measure VEGF. SPSS 20.0 was used to perform analysis of covariance, t-tests, partial correlation analysis, and linear regression.Results: Thinner RNFLs were found in schizophrenia patients (p < 0.001). RNFL showed a significant correlation with SCWT scores (all p < 0.05). Serum level of VEGF was lower in patients with schizophrenia (p = 0.010). Total and inferior RNFL thicknesses of right eyes were positively correlated to VEGF level (RNFL total thickness p = 0.032, inferior thickness p = 0.014).Total RNFL thicknesses were shown to be reduced following a prolonged duration of illness (both p < 0.01).Conclusion: These findings suggest that patients with schizophrenia have degeneration with RNFL thickness following illness duration, which may contribute to neurocognitive impairments observed in schizophrenia. VEGF is speculated to play some important role on RNFL degeneration with schizophrenia patients.Keywords: RNFL, VEGF, cognitive impairment, schizophrenia

Longyou Zhao, 1,* Yun Luo, 2,* Qiao Bian, 3, 4 Liqian Wang, 5 Julian Ye, 6 Xiaojun Song, 4, 7 Jianmin Jiang, 6, 8 Yi-Wei Tang, 9–11 Xianjun Wang, 5 Dazhi Jin 4, 7 1Lishui Second People’s Hospital, Lishui, Zhejiang, People’s Republic of China; 2School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia; 3School of Medicine, Ningbo University, Ningbo, Zhejiang, People’s Republic of China; 4Centre of Laboratory Medicine, Zhejiang Provincial People Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, People’s Republic of China; 5Department of Laboratory Medicine, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of China; 6Department of Microbiology, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, People’s Republic of China; 7School of Laboratory Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, People’s Republic of China; 8Key Laboratory of Vaccine, Prevention and Control of Infectious Disease of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China; 9Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; 10Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY, USA; 11Cepheid, Danaher Diagnostic Platform, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dazhi JinCentre of Laboratory Medicine, Zhejiang Provincial People Hospital, People’s Hospital of Hangzhou Medical College, No. 158 Shangtang Road, Hangzhou, Zhejiang 310014, People’s Republic of ChinaTel/Fax +86-571-87692692Email jind@hmc.edu.cnXianjun Wang Tel/Fax +86-571-56007158Email wangxj0525@126.comBackground: Clostridioides difficile resistant to macrolide-lincosamide-streptogramin B (MLSB) has not been reported in China.Methods: In a cross-sectional study in two tertiary hospitals, C. difficile isolates from stool specimens from community-onset, hospital-associated diarrheal patients were analyzed for toxin genes, genotype, and antibiotic resistance, and the patients’ clinical charts were reviewed.Results: A total of 190 (15.2%) isolates (102 A+B+ and 88 A−B+) from 1250 community acquired (CA) patients were recovered and all were susceptible to vancomycin and metronidazole. High-level resistance (minimum inhibitory concentration > 128 mg/L) to erythromycin and clindamycin was recorded in 77.9% and 88.4% of the tested isolates, respectively. Furthermore, 89.3% (159/178) of the isolates resistant to MLSB carried the erythromycin resistance methylase gene (ermB). The statistically significant factors associated with C. difficile infection (CDI) induced by A−B+ isolates with MLSB resistance included a severity score of > 2 (odds ratio [95% confidence interval], 7.43 [2.31– 23.87]) and platelet count (cells × 10 9 cells/L) < 100 [5.19 (1.58– 17.04)]. The proportion of A−B+ increased with enhanced CDI severity (x 2 = 21.62, P < 0.001), which was significantly higher than that of ermB-positive A+B+ in severity score of 4 (x 2 = 8.61, P = 0.003). The average severity score of ermB-positive isolates was significantly higher than that of ermB-negative isolates in A−B+ (Z = − 2.41, P = 0.016).Conclusion: The ermB-positive A−B+ C. difficile with MLSB resistance is described for the first time as a potential epidemic clone inducing severe CDI in CA diarrheal patients in Eastern China.Keywords: Clostridioides difficile, molecular characteristic, macrolide-lincosamide-streptogramin B resistance

Tooth development is a complex process orchestrated by intricate gene regulatory networks, involving both odontogenic epithelium and ectomesenchyme. Six1, a pivotal transcription factor (TF), is involved in the development of the lower incisor. However, its precise role during incisor development and the molecular mechanisms underpinning its regulatory functions remain poorly understood. This study employs Six1 deletion mouse models to elucidate the critical regulatory role of Six1 in governing dental mesenchyme development. By performing single-cell RNA sequencing, we constructed a comprehensive transcriptome atlas of tooth germ development from the bud to bell stage. Our analyses suggest that the dental follicle and the dental papilla (DP) are differentiated from dental ectomesenchyme (DEM) and identify the key TFs underlying these distinct states. Notably, we show that Dlx1, Dlx2, and Dlx5 (Dlx1 / 2 / 5) may function as the key TFs that promote the formation of DP. We further show that the deletion of Six1 perturbs dental mesenchyme development by impeding the transitions from DEM to DP states. Importantly, SIX1 directly binds to the promoters of Dlx1 / 2 / 5 to promote their co-expression, which subsequently leads to widespread epigenetic and transcriptional remodeling. In summary, our findings unveil Six1 's indispensable role in incisor development, offering key insights into TF-driven regulatory networks that govern dental mesenchyme cell fate transitions during tooth development. [ABSTRACT FROM AUTHOR]

Oxidation flow reactors (OFRs) allow the concentration of a given atmospheric oxidant to be increased beyond ambient levels in order to study secondary organic aerosol (SOA) formation and aging over varying periods of equivalent aging by that oxidant. Previous studies have used these reactors to determine the bulk OA mass and chemical evolution. To our knowledge, no OFR study has focused on the interpretation of the evolving aerosol size distributions. In this study, we use size-distribution measurements of the OFR and an aerosol microphysics model to learn about size-dependent processes in the OFR. Specifically, we use OFR exposures between 0.09 and 0.9 equivalent days of OH aging from the 2011 BEACHON-RoMBAS and GoAmazon2014/5 field campaigns. We use simulations in the TOMAS (TwO-Moment Aerosol Sectional) microphysics box model to constrain the following parameters in the OFR: (1) the rate constant of gas-phase functionalization reactions of organic compounds with OH, (2) the rate constant of gas-phase fragmentation reactions of organic compounds with OH, (3) the reactive uptake coefficient for heterogeneous fragmentation reactions with OH, (4) the nucleation rate constants for three different nucleation schemes, and (5) an effective accommodation coefficient that accounts for possible particle diffusion limitations of particles larger than 60nm in diameter. We find the best model-to-measurement agreement when the accommodation coefficient of the larger particles (Dp>60nm) was 0.1 or lower (with an accommodation coefficient of 1 for smaller particles), which suggests a diffusion limitation in the larger particles. When using these low accommodation-coefficient values, the model agrees with measurements when using a published H2SO4-organics nucleation mechanism and previously published values of rate constants for gas-phase oxidation reactions. Further, gas-phase fragmentation was found to have a significant impact upon the size distribution, and including fragmentation was necessary for accurately simulating the distributions in the OFR. The model was insensitive to the value of the reactive uptake coefficient on these aging timescales. Monoterpenes and isoprene could explain 24%-95% of the observed change in total volume of aerosol in the OFR, with ambient semivolatile and intermediate-volatility organic compounds (S/IVOCs) appearing to explain the remainder of the change in total volume. These results provide support to the mass-based findings of previous OFR studies, give insight to important size-distribution dynamics in the OFR, and enable the design of future OFR studies focused on new particle formation and/or microphysical processes.

Objective·To clarify the regulatory role of CCCTC-binding factor (CTCF) in lipid metabolism in liver cells, and explore the mechanisms by which CTCF regulates liver cell gene expression.Methods·Immortalized AML12 liver cell line was used as a model to investigate the functions of CTCF in liver cells. To stably knock down Ctcf, DNA sequences stably expressing Ctcf shRNA were integrated into AML12 cells through lentivirus. The knockdown efficiency of Ctcf was verified by RT-qPCR and Western blotting. The effects of Ctcf knockdown on cell growth and cell cycle were assessed by performing CCK-8 assay and propidium iodide (PI) staining. Intracellular lipids, labeled with Oil Red O staining, were analyzed and quantified to detect the effect of CTCF on lipid metabolism and lipid droplet accumulation in AML12 cells. Changes in CTCF genome distribution after Ctcf knockdown were analyzed using the Cleavage Under Targets and Tagmentation (CUT&Tag) method. Transcriptome changes in AML12 cells after Ctcf knockdown were quantified by RNA sequencing (RNA-seq). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses, and gene set enrichment analysis (GSEA) were employed to evaluate the functions of differentially expressed genes. The correlation between gene expression changes and CTCF binding changes was further assessed by performing statistical analyses.Results·The result of RT-qPCR showed that Ctcf is downregulated 63.4% in mRNA level and 57.7% in protein level (both P

One outcrop of the NE–SW-trending fault with a steep occurrence and grown gouge was discovered in the north segment of the Tangshan fault zone during a field survey near Jujialing village on the Kaiping-Guye boundary of Hebei province, North China. This zone has received less attention in seismic geologic surveys. In addition, three neighboring and parallel NE trending scarps with heights in the range of 1–1.5 m were discovered on the generally flat terrain close to the fault outcrop. The geochemical and multi-electrode resistivity surveys revealed sudden huge fluctuations in the Hg concentration within short distances from the fault outcrop and the three surface scarps. The multi-electrode resistivity survey also revealed a resistivity structure with extreme horizontal discontinuity, indicating the presence of a subsurface fault zone with a width of 40–50 m and a SE dip. This finding confirmed that the three surface NE trending scarps were late Quaternary fault scarps. Following an examination of the focal mechanism solutions and survey findings, it is suggested that the newly detected fault trending toward the northeast could be an unexplored branch fault in the flower structure of the northern section of the Tangshan fault zone. It is marked by recent activity that is mainly controlled by the right-lateral strike-slip. The discovery of this active fault is critical for an accurate assessment of the seismic hazard of north segment of the Tangshan fault zone.

A magnetization model of nanocrystalline materials incorporating intragrain anisotropies, intergrain interactions, and texture effects has been extended to include the thermal fluctuations. The method relies on the stochastic Landau–Lifshitz–Gilbert theory of magnetization dynamics and permits to study the magnetic properties of nanocrystalline materials at arbitrary temperature below the Currie temperature. The model has been used to determine the intergrain exchange constant and grain boundary anisotropy constant of nanocrystalline Ni at 100K and 298 K. It is found that the thermal fluctuations suppress the strength of the intergrain exchange coupling and also reduce the grain boundary anisotropy. In comparison with its value at 2K, the interparticle exchange constant decreases by 16% and 42% and the grain boundary anisotropy constant decreases by 28% and 40% at 100K and 298 K, respectively. An application of the model to study the grain size-dependent magnetization indicates that when the thermal activation energy is comparable to the free energy of grains, the decrease in the grain size leads to the decrease in the magnetic permeability and saturation magnetization. The mechanism by which the grain size influences the magnetic properties of nc–Ni is discussed. [ABSTRACT FROM AUTHOR]

A theoretical model incorporating the material texture has been developed to simulate the magnetic properties of nanocrystalline materials at low temperatures where the effect of thermal energy on magnetization is neglected. The method is based on Landau-Lifshitz-Gilbert (LLG) theory and it describes the magnetization dynamics of individual grains in the effective field. The modified LLG equation incorporates the intrinsic fields from the intragrain magnetocrystalline and grain boundary anisotropies and the interacting fields from intergrain dipolar and exchange couplings between the neighbouring grains. The model is applied to study magnetic properties of textured nanocrystalline Ni samples at 2K and is capable to reproduce closely the hysteresis loop behaviour at different orientations of applied magnetic field. Nanocrystalline Ni shows the grain boundary anisotropy constant K1s=-6:0 × 104 J=m³ and the intergrain exchange coupling denoted by the effective exchange constant Ap=2.16×10-11 J/m. Analytical expressions to estimate the intergrain exchange energy density and the effective exchange constant have been formulated. [ABSTRACT FROM AUTHOR]

Abstract The vibration of the ball mill foundation will seriously affect the operation stability of the ball mill. According to the connection relationship between the ball mill and the foundation, the mill-foundation transient shock model is established. The effects of shock force, concrete grade and shock angle on the transient response of the foundation were studied. And based on the problem of the mill foundation, the reinforcement scheme of the foundation was put forward. The following conclusions are drawn: with the increase of shock force and shock angle, the displacement of foundation joints increases, and the maximum stress also increases; concrete grade has little effect on foundation stability; after the foundation reinforcement scheme is used, the vibration caused by the shock of the ball mill is effectively reduced, and the stability of the foundation is increased. Finally, the correctness of the model and the scheme is verified through the comparison with the test data. The calculation results provide a reference for the improvement of the ball mill foundation.

Dragonfly network,proposed by Kim et al.,is a topology for high-performance computer systems.In dragonfly network,compute nodes are attached to switches,the switches are organized into groups,and the network is organized as a two-level clique.There is a link between any two nodes in a group,and there is a global link between different groups.Completely independent spanning trees(CISTs) play important roles in reliable information transmission,parallel transmission and safe distribution of information.In practical application,with the continuous increase of network scale,the requirements for information transmission efficiency and security are becoming higher and higher.Therefore,it is meaningful to study the construction of completely independent spanning trees in dragonfly network.At present,there are many results on completely independent spanning trees in networks,but completely independent spanning trees in dragonfly network have not been studied.In this paper,construction algorithm for the global link of dragonfly network is proposed,which is divided into completely independent spanning tree under re-lative link,absolute link and circulant link.Based on this division,a construction algorithm for the edge set of completely independent spanning tree is given,and the correctness of the above algorithms is proved.Finally,the time complexity of these algorithms is analyzed.

With the rapid development of the Internet of Things, the requirements for massive data processing technology are getting higher and higher. Traditional computer data processing capabilities can no longer deliver fast, simple, and efficient data analysis and processing for today’s massive data processing due to the real-time, massive, polymorphic, and heterogeneous characteristics of Internet of Things data. Mass heterogeneous data of different types of subsystems in the Internet of Things need to be processed and stored uniformly, so the mass data processing method is required to be able to integrate multiple different networks, multiple data sources, and heterogeneous mass data and be able to perform processing on these data. Therefore, this article proposes massive data processing and multidimensional database management based on deep learning to meet the needs of contemporary society for massive data processing. This article has deeply studied the basic technical methods of massive data processing, including MapReduce technology, parallel data technology, database technology based on distributed memory databases, and distributed real-time database technology based on cloud computing technology, and constructed a massive data fusion algorithm based on deep learning. The model and the multidimensional online analytical processing model of the multidimensional database based on deep learning analyze the performance, scalability, load balancing, data query, and other aspects of the multidimensional database based on deep learning. It is concluded that the accuracy of multidimensional database query data is as high as 100%, and the accuracy of the average data query time is only 0.0053 s, which is much lower than the general database query time.