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3. The novel Mechanical Ventilator Milano for the COVID-19 pandemic.

Author

Abba, A, Accorsi, C, Agnes, P, Alessi, E, Amaudruz, P, Annovi, A, Desages, F Ardellier, Back, S, Badia, C, Bagger, J, Basile, V, Batignani, G, Bayo, A, Bell, B, Beschi, M, Biagini, D, Bianchi, G, Bicelli, S, Bishop, D, Boccali, T, Bombarda, A, Bonfanti, S, Bonivento, WM, Bouchard, M, Breviario, M, Brice, S, Brown, R, Calvo-Mozota, JM, Camozzi, L, Camozzi, M, Capra, A, Caravati, M, Carlini, M, Ceccanti, A, Celano, B, Cela Ruiz, JM, Charette, C, Cogliati, G, Constable, M, Crippa, C, Croci, G, Cudmore, S, Dahl, CE, Dal Molin, A, Daley, M, Di Guardo, C, D'Avenio, G, Davignon, O, Del Tutto, M, De Ruiter, J, Devoto, A, Diaz Gomez Maqueo, P, Di Francesco, F, Dossi, M, Druszkiewicz, E, Duma, C, Elliott, E, Farina, D, Fernandes, C, Ferroni, F, Finocchiaro, G, Fiorillo, G, Ford, R, Foti, G, Fournier, RD, Franco, D, Fricbergs, C, Gabriele, F, Galbiati, C, Garcia Abia, P, Gargantini, A, Giacomelli, L, Giacomini, F, Giarratana, LS, Gillespie, S, Giorgi, D, Girma, T, Gobui, R, Goeldi, D, Golf, F, Gorel, P, Gorini, G, Gramellini, E, Grosso, G, Guescini, F, Guetre, E, Hackman, G, Hadden, T, Hawkins, W, Hayashi, K, Heavey, A, Hersak, G, Hessey, N, Hockin, G, Hudson, K, Ianni, A, Ienzi, C, Ippolito, V, and James, CC

Subjects
Mathematical Sciences, Physical Sciences, Engineering, Fluids & Plasmas
Abstract

This paper presents the Mechanical Ventilator Milano (MVM), a novel intensive therapy mechanical ventilator designed for rapid, large-scale, low-cost production for the COVID-19 pandemic. Free of moving mechanical parts and requiring only a source of compressed oxygen and medical air to operate, the MVM is designed to support the long-term invasive ventilation often required for COVID-19 patients and operates in pressure-regulated ventilation modes, which minimize the risk of furthering lung trauma. The MVM was extensively tested against ISO standards in the laboratory using a breathing simulator, with good agreement between input and measured breathing parameters and performing correctly in response to fault conditions and stability tests. The MVM has obtained Emergency Use Authorization by U.S. Food and Drug Administration (FDA) for use in healthcare settings during the COVID-19 pandemic and Health Canada Medical Device Authorization for Importation or Sale, under Interim Order for Use in Relation to COVID-19. Following these certifications, mass production is ongoing and distribution is under way in several countries. The MVM was designed, tested, prepared for certification, and mass produced in the space of a few months by a unique collaboration of respiratory healthcare professionals and experimental physicists, working with industrial partners, and is an excellent ventilator candidate for this pandemic anywhere in the world.

Published
2021

15. Sweat analysis with a wearable sensing platform based on laser-induced graphene

Author

Vivaldi, F., Dallinger, A., Poma, N., Bonini, A., Biagini, D., Salvo, P., Borghi, F., Tavanti, A., Greco, F., and Di Francesco, F.

Subjects
Biomaterials, laser induced graphene, resistance, uric acid, Biomedical Engineering, Biophysics, body fluids sampling, Bioengineering, pH sensor, tyrosine, Settore FIS/03 - Fisica della Materia
Abstract

The scientific community has shown increasing interest in laser scribing for the direct fabrication of conductive graphene-based tracks on different substrates. This can enable novel routes for the noninvasive analysis of biofluids (such as sweat or other noninvasive matrices), whose results can provide the rapid evaluation of a person's health status. Here, we present a wearable sensing platform based on laser induced graphene (LIG) porous electrodes scribed on a flexible polyimide sheet, which samples sweat through a paper sampler. The device is fully laser manufactured and features a two layer design with LIG-based vertical interconnect accesses. A detailed characterization of the LIG electrodes including pore size, surface groups, surface area in comparison to electroactive surface area, and the reduction behavior of different LIG types was performed. The bare LIG electrodes can detect the electrochemical oxidation of both uric acid and tyrosine. Further modification of the surface of the LIG working electrode with an indoaniline derivative [4-((4-aminophenyl)imino)-2,6-dimethoxycyclohexa-2,5-dien-1-one] enables the voltammetric measurement of pH with an almost ideal sensitivity and without interference from other analytes. Finally, electrochemical impedance spectroscopy was used to measure the concentrations of ions through the analysis of the sweat impedance. The device was successfully tested in a real case scenario, worn on the skin during a sports session. In vitro tests proved the non-cytotoxic effect of the device on the A549 cell line.

Published
2022

17. The peppermint breath test : A benchmarking protocol for breath sampling and analysis using GC-MS

Author

Wilkinson, M., White, I., Hamshere, K., Holz, O., Schuchardt, S., Bellagambi, F.G., Lomonaco, T., Biagini, D., Di, Francesco F., Fowler, S.J., Beauchamp, J.D., Cristescu, S.M., Focant, J.F., Franchina, F.A., Grassin-Delyle, S., Hadjithekli, A., Henderson, B., Koppen, G.F., Langejürgen, J., Malásková, M., Mayhew, C., Moreno, S., Pedrotti, M., Pugliese, G., Ruszkiewicz, D.M., Salman, D., Sinues, P., Slingers, G.F., Stefanuto, P.H., Thomas, C.L.P., Wilde, M., Zanella, D., and Zenobi, R.

Subjects
Pulmonary and Respiratory Medicine, Benchmarking, Breathomics, Peppermint, Standardisation, Breath Tests, Exhalation, Gas Chromatography-Mass Spectrometry, Humans, Mentha piperita, Volatile Organic Compounds, standardisation, breathomics, peppermint, benchmarking, NO, chemistry.chemical_compound, standardisation, breathomics, peppermint, benchmarking, medicine, VLAG, Protocol (science), Baseline values, Breath test, Chromatography, medicine.diagnostic_test, Breath sampling, Menthone, Eucalyptol, Food Quality and Design, chemistry, Environmental science, Post Harvest Technology, Gas chromatography–mass spectrometry, Menthol
Abstract

Exhaled breath contains hundreds of volatile organic compounds (VOCs) which offer the potential for diagnosing and monitoring a wide range of diseases. As the breath research field has grown, sampling and analytical practices have become highly varied between groups. Standardisation would allow meta-analyses of data from multiple studies and greater confidence in published results. Washout of VOCs from ingestion into the blood and subsequently breath could provide data for an initial assessment of inter-group performance. The Peppermint Initiative has been formed to address this task of standardisation. In the current study we aimed to generate initial benchmark values for thermal desorption–gas chromatography–mass spectrometry (TD–GC–MS) analysis of breath samples containing peppermint-derived VOCs using data from three independent European research groups. Initially, headspace analysis of peppermint oil capsules was performed to determine compounds of interest. Ten healthy participants were recruited by each three groups across Europe. The standard Peppermint protocol was followed. In brief, each participant provided a baseline breath sample prior to taking a peppermint capsule, with further samples collected at 60, 90, 165, 285 and 360 min following ingestion. Sampling and analytical protocols were different for each group, in line with their usual practice. Samples were analysed by TD–GC–MS and benchmarking values determined for the time taken for detected peppermint VOCs to return to baseline values. Sixteen compounds were identified in the capsule headspace, and all were confirmed in breath following ingestion of the peppermint capsules. Additionally, 2,3-dehydro-1,8-cineole was uniquely found in the breath samples, with a washout profile that suggested it was a product of metabolism of peppermint compounds. Five compounds (α-pinene, β-pinene, eucalyptol, menthol and menthone) were quantified by all three groups. Differences were observed between the groups, particularly for the recovery of menthone and menthol. The average time taken for VOCs to return to baseline was selected as the benchmark and were 377, 423, 533, 418 and 336 min for α-pinene, β-pinene, eucalyptol, menthone and menthol respectively. We have presented an initial set of easy-to-measure benchmarking values for assessing the performance of TD–GC–MS systems for the analysis of VOCs in breath. These values will be updated when more groups provide additional data., Journal of Breath Research, 15 (2), ISSN:1752-7155, ISSN:1752-7163

Published
2021

28. Determination of volatile organic compounds in exhaled breath of heart failure patients by needle trap micro-extraction coupled with gas chromatography-tandem mass spectrometry

Author

Biagini, D, primary, Lomonaco, T, additional, Ghimenti, S, additional, Bellagambi, F G, additional, Onor, M, additional, Scali, M C, additional, Barletta, V, additional, Marzilli, M, additional, Salvo, P, additional, Trivella, M G, additional, Fuoco, R, additional, and Di Francesco, F, additional

Published
2017
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29. Determination of Warfarin and Warfarin alcohols in oral fluid and plasma samples for monitoring patients undergoing anticoagulant therapy

Author

Tommaso Lomonaco, Ghimenti, Silvia, Piga, I., Biagini, D., Onor, Massimo, Roger Fuoco, ALDO PAOLICCHI, Ruocco, L., Pellegrini, G., Trivella, M. G., Fabio Di Francesco, Lomonaco, T, Ghimenti, S, Piga, I, Biagini, D, Onor, M, Fuoco, R, Paolicchi, A, Ruocco, L, Pellegrini, G, Trivella, M, and Di Francesco, F

Subjects
HPLC, WARFARIN, Warfarin alcohols, oral fluid, plasma
Published
2013

44. Manometric investigation of the entire esophagus in healthy subjects and patients with high-amplitude peristaltic contractions.

Author

Bassotti, Gabrio, Bacci, Giuseppe, Biagini, Dino, David, Piero, Alunni, Gianfranco, Pelli, Maria, Morelli, Antonio, Bassotti, G, Bacci, G, Biagini, D, David, P, Alunni, G, Pelli, M A, and Morelli, A

Abstract

Normal esophageal motor parameters and nuteracker esophagus have never been well characterized in Italy. For this reason, we investigated 33 patients with nutcracker esophagus and compared them with 34 age- and sex-matched volunteers. Esophageal manometry revealed that lower esophageal sphincter pressure and contraction amplitude at 3, 8, 13, and 18 cm above the lower esophageal sphincter were significantly higher in patients ( p<0.05). In addition, bi- and tripeaked waves were significantly increased in the patients at all esophageal recording levels. No significant differences were found between the 9 patients and 17 controls who were also evaluated for upper esophageal sphincter pressure. [ABSTRACT FROM AUTHOR]

Published
1988
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49. The novel Mechanical Ventilator Milano for the COVID-19 pandemic

Author

M. Tardocchi, P. Lu, Silvia Bonfanti, C. Fricbergs, J. M. Cela Ruiz, M. Del Tutto, R. Brown, D. Salomoni, C. Jillings, A. Visioli, A. Abba, B. Smith, P. Stringari, Valerio Ippolito, K. Olchanski, S. Yue, A. Razeto, L. Parmeggiano, M. Beschi, I. Palumbo, C. C. James, M. Daley, Andrea Bombarda, Eugenio Scapparone, T. Boccali, D. Vonica, G. Luzón, E. Panontin, Nigel Hessey, E. Elliott, O. Putignano, R. Maharaj, M. H. L. S. Wang, M. Laclaustra, A. Sher, E. Gramellini, P. Napoli, S. Parmeggiano, E. Meazzi, S. Sala, A. Muraro, T. Girma, D. Trask, A. Lennarz, F. Golf, G. Magni, C. Di Guardo, A. S. Slutsky, C. Lim, B. Shaw, C. Duma, V. Pesudo, S. Gillespie, A. Devoto, E. Guetre, L. Camozzi, B. Bell, C. E. Dahl, M. Dossi, E. Alessi, M. MacDonald, A. J. Noble, F. Ardellier Desages, O. Davignon, B. Morrison, R. D. Fournier, Alberto Annovi, S. Kuula, Elvinia Riccobene, A. Rizzi, G. Hersak, J. Bagger, S. Brice, S. Khan, L. VanPagee, P. Salvo, R. Lubna, A. Bayo, M. Bouchard, J. Romualdez, G. Bianchi, H. Wang, S. Bicelli, T. A. Mohayai, A. Dal Molin, M. Breviario, C. Ienzi, M. Carlini, K. Hayashi, G. Monzani, G. A. Lukhanin, R. J. Ford, D. Yates, B. Velghe, G. Finocchiaro, C. Charette, M.H. Kushoro, E. Sansoucy, D. Reed, Pierre-Andre Amaudruz, A. Pocar, S. Scorza, M. Camozzi, T. Reilly, C. Crippa, S. Pordes, F. Padula, S. Westerdale, C. Straubel, P. Garcia Abia, A. Shi, D. Giorgi, A. Capra, S. Shawyer, S. Martin, F. Prelz, S. Back, D. Sablone, L. Takeuchi, D. Franco, L. Martin, An. Ianni, L. Tseng, P. McClurg, M. I. Martínez, D. Wood, A. Norrick, C. Pellegrino, J. Tseng, C. Ratti, M. Constable, V. Vedia, L. M. Tosatti, L. S. Giarratana, G. Fiorillo, M. Razeti, A. Patel, C. R. Natzke, S. Manni, M. Wada, S. Tacchino, M. Paterno, P. Gorel, P. Diaz Gomez Maqueo, N. Massacret, S. Cudmore, Marco Pallavicini, A. Heavey, Gabriele Croci, E. Kim, B. Celano, G. Batignani, E. Druszkiewicz, A. L. Renshaw, L. Giacomelli, D. Walter, S. Viel, Angelo Gargantini, D. Goeldi, P. Liimatainen, N. J. T. Smith, T. Schaubel, G. Cogliati, G. Foti, C. Mapelli, F. Retriere, Giuseppe Gorini, K. Patel, R. Tartaglia, N. Papini, M. Settimo, P. Pelliccione, P. Skensved, M. Leyton, V. Basile, A. Kittmer, G. D'Avenio, D. Rigamonti, R. Krücken, F. Guescini, F. Giacomini, E. Thomas, K. Hudson, Claudio Moretti, R. Santorelli, G. Hackman, R. Gobui, L. Viviani, C. Savarese, I. Kochanek, R. Migalla, J. Rode, F. Gabriele, D. Farina, F. Ferroni, F. Di Francesco, J. M. Calvo-Mozota, M. Suchenek, G. Hockin, J. Refsgaard, J. Kowalkowski, A. Pope, T. Lomonaco, S. King, Bhaskar Sur, C. L. Kendziora, M. Caravati, A. Ceccanti, W. Hawkins, W. Bonivento, C. Fernandes, G. Leblond, M. Mountaniol, A. B. McDonald, C. Accorsi, A. Stenzler, Federico Nati, V. Zambrano, D. Bishop, M. King, A. Sandoval, X. Li, P. Margetak, P. Agnes, J. L. Raaf, J. De Ruiter, Cristiano Galbiati, Giovanni Grosso, L. Lee, A. Ortiz de Solórzano, T. Hadden, T. Lindner, D. Biagini, L. Russel, C. Badia, Abba, A., Accorsi, C., Agnes, P., Alessi, E., Amaudruz, P., Annovi, A., Desages, F. A., Back, S., Badia, C., Bagger, J., Basile, V., Batignani, G., Bayo, A., Bell, B., Beschi, M., Biagini, D., Bianchi, G., Bicelli, S., Bishop, D., Boccali, T., Bombarda, A., Bonfanti, S., Bonivento, W. M., Bouchard, M., Breviario, M., Brice, S., Brown, R., Calvo-Mozota, J. M., Camozzi, L., Camozzi, M., Capra, A., Caravati, M., Carlini, M., Ceccanti, A., Celano, B., Cela Ruiz, J. M., Charette, C., Cogliati, G., Constable, M., Crippa, C., Croci, G., Cudmore, S., Dahl, C. E., Dal Molin, A., Daley, M., Di Guardo, C., D'Avenio, G., Davignon, O., Del Tutto, M., De Ruiter, J., Devoto, A., Diaz Gomez Maqueo, P., Di Francesco, F., Dossi, M., Druszkiewicz, E., Duma, C., Elliott, E., Farina, D., Fernandes, C., Ferroni, F., Finocchiaro, G., Fiorillo, G., Ford, R., Foti, G., Fournier, R. D., Franco, D., Fricbergs, C., Gabriele, F., Galbiati, C., Garcia Abia, P., Gargantini, A., Giacomelli, L., Giacomini, F., Giarratana, L. S., Gillespie, S., Giorgi, D., Girma, T., Gobui, R., Goeldi, D., Golf, F., Gorel, P., Gorini, G., Gramellini, E., Grosso, G., Guescini, F., Guetre, E., Hackman, G., Hadden, T., Hawkins, W., Hayashi, K., Heavey, A., Hersak, G., Hessey, N., Hockin, G., Hudson, K., Ianni, A., Ienzi, C., Ippolito, V., James, C. C., Jillings, C., Kendziora, C., Khan, S., Kim, E., King, M., King, S., Kittmer, A., Kochanek, I., Kowalkowski, J., Krucken, R., Kushoro, M., Kuula, S., Laclaustra, M., Leblond, G., Lee, L., Lennarz, A., Leyton, M., Li, X., Liimatainen, P., Lim, C., Lindner, T., Lomonaco, T., Lu, P., Lubna, R., Lukhanin, G. A., Luzon, G., Macdonald, M., Magni, G., Maharaj, R., Manni, S., Mapelli, C., Margetak, P., Martin, L., Martin, S., Martinez, M., Massacret, N., Mcclurg, P., Mcdonald, A. B., Meazzi, E., Migalla, R., Mohayai, T., Tosatti, L. M., Monzani, G., Moretti, C., Morrison, B., Mountaniol, M., Muraro, A., Napoli, P., Nati, F., Natzke, C. R., Noble, A. J., Norrick, A., Olchanski, K., Ortiz De Solorzano, A., Padula, F., Pallavicini, M., Palumbo, I., Panontin, E., Papini, N., Parmeggiano, L., Parmeggiano, S., Patel, K., Patel, A., Paterno, M., Pellegrino, C., Pelliccione, P., Pesudo, V., Pocar, A., Pope, A., Pordes, S., Prelz, F., Putignano, O., Raaf, J. L., Ratti, C., Razeti, M., Razeto, A., Reed, D., Refsgaard, J., Reilly, T., Renshaw, A., Retriere, F., Riccobene, E., Rigamonti, D., Rizzi, A., Rode, J., Romualdez, J., Russel, L., Sablone, D., Sala, S., Salomoni, D., Salvo, P., Sandoval, A., Sansoucy, E., Santorelli, R., Savarese, C., Scapparone, E., Schaubel, T., Scorza, S., Settimo, M., Shaw, B., Shawyer, S., Sher, A., Shi, A., Skensved, P., Slutsky, A., Smith, B., Smith, N. J. T., Stenzler, A., Straubel, C., Stringari, P., Suchenek, M., Sur, B., Tacchino, S., Takeuchi, L., Tardocchi, M., Tartaglia, R., Thomas, E., Trask, D., Tseng, J., Tseng, L., Vanpagee, L., Vedia, V., Velghe, B., Viel, S., Visioli, A., Viviani, L., Vonica, D., Wada, M., Walter, D., Wang, H., Wang, M. H. L. S., Westerdale, S., Wood, D., Yates, D., Yue, S., Zambrano, V., AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), École des Mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Abba, A, Accorsi, C, Agnes, P, Alessi, E, Amaudruz, P, Annovi, A, Desages, F, Back, S, Badia, C, Bagger, J, Basile, V, Batignani, G, Bayo, A, Bell, B, Beschi, M, Biagini, D, Bianchi, G, Bicelli, S, Bishop, D, Boccali, T, Bombarda, A, Bonfanti, S, Bonivento, W, Bouchard, M, Breviario, M, Brice, S, Brown, R, Calvo-Mozota, J, Camozzi, L, Camozzi, M, Capra, A, Caravati, M, Carlini, M, Ceccanti, A, Celano, B, Cela Ruiz, J, Charette, C, Cogliati, G, Constable, M, Crippa, C, Croci, G, Cudmore, S, Dahl, C, Dal Molin, A, Daley, M, Di Guardo, C, D'Avenio, G, Davignon, O, Del Tutto, M, De Ruiter, J, Devoto, A, Diaz Gomez Maqueo, P, Di Francesco, F, Dossi, M, Druszkiewicz, E, Duma, C, Elliott, E, Farina, D, Fernandes, C, Ferroni, F, Finocchiaro, G, Fiorillo, G, Ford, R, Foti, G, Fournier, R, Franco, D, Fricbergs, C, Gabriele, F, Galbiati, C, Garcia Abia, P, Gargantini, A, Giacomelli, L, Giacomini, F, Giarratana, L, Gillespie, S, Giorgi, D, Girma, T, Gobui, R, Goeldi, D, Golf, F, Gorel, P, Gorini, G, Gramellini, E, Grosso, G, Guescini, F, Guetre, E, Hackman, G, Hadden, T, Hawkins, W, Hayashi, K, Heavey, A, Hersak, G, Hessey, N, Hockin, G, Hudson, K, Ianni, A, Ienzi, C, Ippolito, V, James, C, Jillings, C, Kendziora, C, Khan, S, Kim, E, King, M, King, S, Kittmer, A, Kochanek, I, Kowalkowski, J, Krucken, R, Kushoro, M, Kuula, S, Laclaustra, M, Leblond, G, Lee, L, Lennarz, A, Leyton, M, Li, X, Liimatainen, P, Lim, C, Lindner, T, Lomonaco, T, Lu, P, Lubna, R, Lukhanin, G, Luzon, G, Macdonald, M, Magni, G, Maharaj, R, Manni, S, Mapelli, C, Margetak, P, Martin, L, Martin, S, Martinez, M, Massacret, N, Mcclurg, P, Mcdonald, A, Meazzi, E, Migalla, R, Mohayai, T, Tosatti, L, Monzani, G, Moretti, C, Morrison, B, Mountaniol, M, Muraro, A, Napoli, P, Nati, F, Natzke, C, Noble, A, Norrick, A, Olchanski, K, Ortiz De Solorzano, A, Padula, F, Pallavicini, M, Palumbo, I, Panontin, E, Papini, N, Parmeggiano, L, Parmeggiano, S, Patel, K, Patel, A, Paterno, M, Pellegrino, C, Pelliccione, P, Pesudo, V, Pocar, A, Pope, A, Pordes, S, Prelz, F, Putignano, O, Raaf, J, Ratti, C, Razeti, M, Razeto, A, Reed, D, Refsgaard, J, Reilly, T, Renshaw, A, Retriere, F, Riccobene, E, Rigamonti, D, Rizzi, A, Rode, J, Romualdez, J, Russel, L, Sablone, D, Sala, S, Salomoni, D, Salvo, P, Sandoval, A, Sansoucy, E, Santorelli, R, Savarese, C, Scapparone, E, Schaubel, T, Scorza, S, Settimo, M, Shaw, B, Shawyer, S, Sher, A, Shi, A, Skensved, P, Slutsky, A, Smith, B, Smith, N, Stenzler, A, Straubel, C, Stringari, P, Suchenek, M, Sur, B, Tacchino, S, Takeuchi, L, Tardocchi, M, Tartaglia, R, Thomas, E, Trask, D, Tseng, J, Tseng, L, Vanpagee, L, Vedia, V, Velghe, B, Viel, S, Visioli, A, Viviani, L, Vonica, D, Wada, M, Walter, D, Wang, H, Wang, M, Westerdale, S, Wood, D, Yates, D, Yue, S, and Zambrano, V

Subjects
ventilator, Emergency Use Authorization, Coronavirus disease 2019 (COVID-19), Fault conditions, Computational Mechanics, Certification, 01 natural sciences, 010305 fluids & plasmas, law.invention, Mechanical parts, Food and drug administration, Compressed oxygen, Food and Drug Administration, Health care professionals, Industrial partners, Intensive therapy, Ventilation mode, Mechanical ventilator, law, 0103 physical sciences, Pandemic, medicine, 010306 general physics, Fluid Flow and Transfer Processes, Physics, [PHYS]Physics [physics], Mechanical Engineering, healthcare, Articles, Condensed Matter Physics, medicine.disease, 3. Good health, Medical gas supply, Mechanical Ventilation, COVID-19 Pandemic, covid-19, Mechanics of Materials, Others, Ventilation (architecture), Medical emergency, Settore ING-INF/05 - Sistemi di Elaborazione delle Informazioni, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract

International audience; This paper presents the Mechanical Ventilator Milano (MVM), a novel intensive therapy mechanical ventilator designed for rapid, large-scale, low-cost production for the COVID-19 pandemic. Free of moving mechanical parts and requiring only a source of compressed oxygen and medical air to operate, the MVM is designed to support the long-term invasive ventilation often required for COVID-19 patients and operates in pressure-regulated ventilation modes, which minimize the risk of furthering lung trauma. The MVM was extensively tested against ISO standards in the laboratory using a breathing simulator, with good agreement between input and measured breathing parameters and performing correctly in response to fault conditions and stability tests. The MVM has obtained Emergency Use Authorization by U.S. Food and Drug Administration (FDA) for use in healthcare settings during the COVID-19 pandemic and Health Canada Medical Device Authorization for Importation or Sale, under Interim Order for Use in Relation to COVID-19. Following these certifications, mass production is ongoing and distribution is under way in several countries. The MVM was designed, tested, prepared for certification, and mass produced in the space of a few months by a unique collaboration of respiratory healthcare professionals and experimental physicists, working with industrial partners, and is an excellent ventilator candidate for this pandemic anywhere in the world

Published
2021

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