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Mass spectrometry imaging is a technique uniquely suited to localize and identify lipids in a tissue sample. Using an atmospheric pressure (AP-) matrix-assisted laser desorption ionization (MALDI) source coupled to an Orbitrap Elite, numerous lipid locations and structures can be determined in high mass resolution spectra and at cellular spatial resolution, but careful sample preparation is necessary. We tested 11 protocols on serial brain sections for the commonly used MALDI matrices CHCA, norharmane, DHB, DHAP, THAP, and DAN in combination with tissue washing and matrix additives to determine the lipid coverage, signal intensity, and spatial resolution achievable with AP-MALDI. In positive-ion mode, the most lipids could be detected with CHCA and THAP, while THAP and DAN without additional treatment offered the best signal intensities. In negative-ion mode, DAN showed the best lipid coverage and DHAP performed superiorly for gangliosides. DHB produced intense cholesterol signals in the white matter. One hundred fifty-five lipids were assigned in positive-ion mode (THAP) and 137 in negative-ion mode (DAN), and 76 peaks were identified using on-tissue tandem-MS. The spatial resolution achievable with DAN was 10 μm, confirmed with on tissue line-scans. This enabled the association of lipid species to single neurons in AP-MALDI images. The results show that the performance of AP-MALDI is comparable to vacuum MALDI techniques for lipid imaging. [ABSTRACT FROM AUTHOR]

Transparent thin‐film piezoelectric transducers are attractive for haptic displays. However, for their widespread use in consumer electronics, innovative and cost‐effective processing methods need to be developed. In this contribution the effectiveness of the deposition of lead zirconate titanate thin films by inkjet printing for the fabrication of haptic devices is demonstrated. The 1,3‐propanediol solvent is used to prepare effective inkjet‐printing inks from chemical solution deposition solutions. The printed thin‐film structures on fused silica glass substrates are 900 nm thick and strongly {100} oriented perovskite phase is detected in X‐ray diffraction patterns. To fabricate devices, interdigitated capacitors and SU‐8 insulation layers are deposited on top of the printed lead zirconate titanate. Dimensions of the final device are 15.7 × 3.4 mm2. A standing antisymmetric Lamb wave is observed at 63.3 kHz, with out‐of‐plane displacement reaching 2 µm at an applied voltage of 100 V. This value exceeds the limit at which the texture rendering function can be induced in the device. Good functional performance of the device is linked with good electromechanical properties of the printed piezoelectric, with permittivity ε ′ and piezoelectric coefficient e33,f values of 1000 and 7.7 C m−2, respectively, which are comparable to films prepared by standard spin‐coating process. [ABSTRACT FROM AUTHOR]

A transparent device, based on printed piezoelectric lead zirconate titanate and interdigitated indium tin oxide electrodes, exhibits a standing Lamb wave at 63.3 kHz. Keywords: haptics; inkjet printing; lead zirconate titanate; piezoelectric; thin films; transparent electronics EN haptics inkjet printing lead zirconate titanate piezoelectric thin films transparent electronics 1 1 1 08/16/22 20220801 NES 220801 B Transparent Haptics b Effectiveness of inkjet printing of piezoelectric thin films for haptic devices is demonstrated in article number 2200147 by Sebastjan Glinsek and co-workers. Haptics, inkjet printing, lead zirconate titanate, piezoelectric, thin films, transparent electronics. [Extracted from the article]

The liquid-solid interface is of great importance in fundamental and applied research. However, the in-situ characterization of liquid-solid interfaces is very challenging. In this work, we demonstrated that {1H–29Si-}1H multiple-contact cross polarization with indirect detection (MCPi) solid-state nuclear magnetic resonance (ssNMR) spectroscopy is an excellent tool for studying dehydration and deuterium exchange at the solvent-silica interface. The results provided direct evidence that the physically adsorbed water molecules present on the silica surface were completely removed in the presence of DMSO, while the silanol groups were satisfactorily deuterated in the presence of a DMSO-D 2 O mixture. The knowledge obtained from the {1H–29Si-}1H MCPi experiment was also extended to the development of an 1H liquid-state NMR-based technique for the quantification of moisture and hydroxyls on inorganic and organic solids, as an alternative to the conventional thermogravimetric analysis (TGA) but with broader applicability. Moreover, this study offers a promising tool for studying the challenging questions involving liquid-solid interface. [Display omitted] [ABSTRACT FROM AUTHOR]