1. Engineered bacterial therapeutics for detecting and treating CRC
- Author
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Siguenza, Nicole, Brevi, Arianna, Zhang, Joanna T, Pabani, Arman, Bhushan, Abhinav, Das, Moumita, Ding, Yousong, Hasty, Jeff, Ghosh, Pradipta, and Zarrinpar, Amir
- Subjects
Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Colo-Rectal Cancer ,Prevention ,Cancer ,Bioengineering ,Digestive Diseases ,5.1 Pharmaceuticals ,4.1 Discovery and preclinical testing of markers and technologies ,Colorectal Neoplasms ,Humans ,Genetic Engineering ,Animals ,Tumor Microenvironment ,Bacteria ,Early Detection of Cancer ,detection ,engraftment ,live bacterial therapeutics ,treatment ,Oncology and carcinogenesis - Abstract
Despite an overall decrease in occurrence, colorectal cancer (CRC) remains the third most common cause of cancer deaths in the USA. Detection of CRC is difficult in high-risk groups, including those with genetic predispositions, with disease traits, or from certain demographics. There is emerging interest in using engineered bacteria to identify early CRC development, monitor changes in the adenoma and CRC microenvironment, and prevent cancer progression. Novel genetic circuits for cancer therapeutics or functions to enhance existing treatment modalities have been tested and verified in vitro and in vivo. Inclusion of biocontainment measures would prepare strains to meet therapeutic standards. Thus, engineered bacteria present an opportunity for detection and treatment of CRC lesions in a highly sensitive and specific manner.
- Published
- 2024