Search

Your search keyword '"Bhaw, Leena"' showing total 10 results
Start Over Author "Bhaw, Leena"
10 results on '"Bhaw, Leena"'

2. c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells

Author

Gabryšová, Leona, Alvarez-Martinez, Marisol, Luisier, Raphaëlle, Cox, Luke S., Sodenkamp, Jan, Hosking, Caroline, Pérez-Mazliah, Damián, Whicher, Charlotte, Kannan, Yashaswini, Potempa, Krzysztof, Wu, Xuemei, Bhaw, Leena, Wende, Hagen, Sieweke, Michael H., Elgar, Greg, Wilson, Mark, Briscoe, James, Metzis, Vicki, Langhorne, Jean, Luscombe, Nicholas M., and O’Garra, Anne

Published
2018
Full Text
View/download PDF

3. Publisher Correction: c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells

Author

Gabryšová, Leona, Alvarez-Martinez, Marisol, Luisier, Raphaëlle, Cox, Luke S., Sodenkamp, Jan, Hosking, Caroline, Pérez-Mazliah, Damián, Whicher, Charlotte, Kannan, Yashaswini, Potempa, Krzysztof, Wu, Xuemei, Bhaw, Leena, Wende, Hagen, Sieweke, Michael H., Elgar, Greg, Wilson, Mark, Briscoe, James, Metzis, Vicki, Langhorne, Jean, Luscombe, Nicholas M., and O’Garra, Anne

Published
2019
Full Text
View/download PDF

4. Neurodevelopment : Lineage-dependent spatial and functional organization of the mammalian enteric nervous system

Author

Lasrado, Reena, Boesmans, Werend, Kleinjung, Jens, Pin, Carmen, Bell, Donald, Bhaw, Leena, McCallum, Sarah, Zong, Hui, Luo, Liqun, Clevers, Hans, Vanden Berghe, Pieter, and Pachnis, Vassilis

Subjects
Medicine(all), Journal Article, General
Abstract

The enteric nervous system(ENS) is essential for digestive function and gut homeostasis. Here we show that the amorphous neuroglia networks of the mouse ENS are composed of overlapping clonal units founded by postmigratory neural crest-derived progenitors.The spatial configuration of ENS clones depends on proliferation-driven local interactions of ENS progenitors with lineally unrelated neuroectodermal cells, the ordered colonization of the serosa-mucosa axis by clonal descendants, and gut expansion. Single-cell transcriptomics and mutagenesis analysis delineated dynamic molecular states of ENS progenitors and identified RETas a regulator of neurogenic commitment. Clonally related enteric neurons exhibit synchronous activity in response to network stimulation. Thus, lineage relationships underpin the organization of the peripheral nervous system.

Published
2017

5. Neurodevelopment: Lineage-dependent spatial and functional organization of the mammalian enteric nervous system

Author

CMM Sectie Molecular Cancer Research, Hubrecht Institute with UMC, Cancer, Regenerative Medicine and Stem Cells, Child Health, Lasrado, Reena, Boesmans, Werend, Kleinjung, Jens, Pin, Carmen, Bell, Donald, Bhaw, Leena, McCallum, Sarah, Zong, Hui, Luo, Liqun, Clevers, Hans, Vanden Berghe, Pieter, Pachnis, Vassilis, CMM Sectie Molecular Cancer Research, Hubrecht Institute with UMC, Cancer, Regenerative Medicine and Stem Cells, Child Health, Lasrado, Reena, Boesmans, Werend, Kleinjung, Jens, Pin, Carmen, Bell, Donald, Bhaw, Leena, McCallum, Sarah, Zong, Hui, Luo, Liqun, Clevers, Hans, Vanden Berghe, Pieter, and Pachnis, Vassilis

Published
2017

6. Increased Vascular Permeability in the Bone Marrow Microenvironment Contributes to Disease Progression and Drug Response in Acute Myeloid Leukemia

Author

Passaro, Diana, primary, Di Tullio, Alessandro, additional, Abarrategi, Ander, additional, Rouault-Pierre, Kevin, additional, Foster, Katie, additional, Ariza-McNaughton, Linda, additional, Montaner, Beatriz, additional, Chakravarty, Probir, additional, Bhaw, Leena, additional, Diana, Giovanni, additional, Lassailly, François, additional, Gribben, John, additional, and Bonnet, Dominique, additional

Published
2017
Full Text
View/download PDF

8. Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours

Author

Blaas, Leander, primary, Pucci, Fabio, additional, Messal, Hendrik A., additional, Andersson, Agneta B., additional, Josue Ruiz, E., additional, Gerling, Marco, additional, Douagi, Iyadh, additional, Spencer-Dene, Bradley, additional, Musch, Alexandra, additional, Mitter, Richard, additional, Bhaw, Leena, additional, Stone, Richard, additional, Bornhorst, Dorothee, additional, Sesay, Abdul K., additional, Jonkers, Jos, additional, Stamp, Gordon, additional, Malanchi, Ilaria, additional, Toftgård, Rune, additional, and Behrens, Axel, additional

Published
2016
Full Text
View/download PDF

9. c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+T cells

Author

Gabryšová, Leona, Alvarez-Martinez, Marisol, Luisier, Raphaëlle, Cox, Luke, Sodenkamp, Jan, Hosking, Caroline, Pérez-Mazliah, Damián, Whicher, Charlotte, Kannan, Yashaswini, Potempa, Krzysztof, Wu, Xuemei, Bhaw, Leena, Wende, Hagen, Sieweke, Michael, Elgar, Greg, Wilson, Mark, Briscoe, James, Metzis, Vicki, Langhorne, Jean, Luscombe, Nicholas, and O’Garra, Anne

Abstract

The transcription factor c-Maf induces the anti-inflammatory cytokine IL-10 in CD4+T cells in vitro. However, the global effects of c-Maf on diverse immune responses in vivo are unknown. Here we found that c-Maf regulated IL-10 production in CD4+T cells in disease models involving the TH1 subset of helper T cells (malaria), TH2 cells (allergy) and TH17 cells (autoimmunity) in vivo. Although mice with c-Maf deficiency targeted to T cells showed greater pathology in TH1 and TH2 responses, TH17 cell–mediated pathology was reduced in this context, with an accompanying decrease in TH17 cells and increase in Foxp3+regulatory T cells. Bivariate genomic footprinting elucidated the c-Maf transcription-factor network, including enhanced activity of NFAT; this led to the identification and validation of c-Maf as a negative regulator of IL-2. The decreased expression of the gene encoding the transcription factor RORγt (Rorc) that resulted from c-Maf deficiency was dependent on IL-2, which explained the in vivo observations. Thus, c-Maf is a positive and negative regulator of the expression of cytokine-encoding genes, with context-specific effects that allow each immune response to occur in a controlled yet effective manner. The transcription factor c-Maf controls IL-10 production in T cells. O’Garra and colleagues use systems and in vivo functional analysis of T cell subsets to reveal distinct context-specific roles for c-Maf.

Published
2018
Full Text
View/download PDF

10. Publisher Correction: c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+T cells

Author

Gabryšová, Leona, Alvarez-Martinez, Marisol, Luisier, Raphaëlle, Cox, Luke S., Sodenkamp, Jan, Hosking, Caroline, Pérez-Mazliah, Damián, Whicher, Charlotte, Kannan, Yashaswini, Potempa, Krzysztof, Wu, Xuemei, Bhaw, Leena, Wende, Hagen, Sieweke, Michael H., Elgar, Greg, Wilson, Mark, Briscoe, James, Metzis, Vicki, Langhorne, Jean, Luscombe, Nicholas M., and O’Garra, Anne

Abstract

In the version of this article initially published, the Supplementary Data file was an incorrect version. The correct version is now provided. The error has been corrected in the HTML and PDF version of the article.

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results