1. Long-term, real world experience of ventricular tachycardia and granulomatous cardiomyopathy
- Author
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Shomu Bohora, Zeeshan Mumtaz, Milind Phadke, Vishnu Bhute, Varun Bhatia, Amit Vora, Ajay Naik, Ashish Nabar, Bhavin Jankharia, Pradeep Vaideeswar, Gopi Panicker, Ujwal Bhure, and Yash Lokhandwala
- Subjects
Sarcoidosis ,Tuberculosis ,Ventricular tachycardia ,Cardiac imaging ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: Granulomatous cardiomyopathy (GCM) is relatively uncommon in patients presenting with ventricular tachycardia (VT). Sarcoidosis and tuberculosis are the most common causes of GCM with VT. The aim of study was to evaluate their clinical characteristics and the long-term outcomes. Methods: We retrospectively analyzed patients from March 2004 to January 2020, presenting with VT and subsequently diagnosed to have GCM. Patients were divided into three groups (sarcoid, tuberculosis and indeterminate) based on serologic tests, imaging and histopathology. The response to anti-arrhythmic and disease specific therapy on long-term follow-up were analyzed. Results: There were 52 patients, comprising 27 males and 25 females, age 40 ± 10 years. The follow-up period was 5.9 ± 3.9 years. Sarcoidosis was diagnosed in 20 (38%); tuberculosis (TB) in 15(29%) and 17(33%) patients were indeterminate. Left ventricular ejection fraction (LVEF) of the entire cohort was 0.45 ± 0.14. Erythrocyte Sedimentation Rate(ESR) was found to be significantly higher in TB(43.6 ± 18.4) patients vs sarcoid(18.9 ± 6.7)p
- Published
- 2022
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