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584 results on '"Bhatia H"'

5. Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production

Author

Candelario-Jalil, E., Akundi, R. S., Bhatia, H. S., Lieb, K., Appel, K., Munoz, E., Hull, M., and Fiebich, B. L.

Subjects
Quantitative Biology - Subcellular Processes, Quantitative Biology - Molecular Networks
Abstract

In the present study, we show that ascorbic acid dose-dependently inhibited interleukin-1beta (IL-1beta)-mediated PGE2 synthesis in the human neuronal cell line, SK-N-SH. Furthermore, in combination with aspirin, ascorbic acid augmented the inhibitory effect of aspirin on PGE2 synthesis. However, ascorbic acid had no synergistic effect along with other COX inhibitors (SC-58125 and indomethacin). The inhibition of IL-1beta-mediated PGE2 synthesis by ascorbic acid was not due to the inhibition of the expression of COX-2 or microsomal prostaglandin E synthase (mPGES-1). Rather, ascorbic acid dose-dependently (0.1-100 microM) produced a significant reduction in IL-1beta-mediated production of 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha), a reliable indicator of free radical formation, suggesting that the effects of ascorbic acid on COX-2-mediated PGE2 biosynthesis may be the result of the maintenance of the neuronal redox status since COX activity is known to be enhanced by oxidative stress. Our results provide in vitro evidence that the neuroprotective effects of ascorbic acid may depend, at least in part, on its ability to reduce neuronal COX-2 activity and PGE2 synthesis, owing to its antioxidant properties. Further, these experiments suggest that a combination of aspirin with ascorbic acid constitutes a novel approach to render COX-2 more sensitive to inhibition by aspirin, allowing an anti-inflammatory therapy with lower doses of aspirin, thereby avoiding the side effects of the usually high dose aspirin treatment.

Published
2007

8. Life, Poetical and Critical Concerns.

Author

Bhatia, H. S.

Subjects
HUMAN beings, ENGLISH poetry
Abstract

The article discusses author's personal and creative journey, touching on themes like the challenges of interpretation in reading texts and instances of critical feedback received, highlighting the complexity of self-expression in poetry.

Published
2023
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9. Variable Precision Computing

Author

Hittinger, J A, primary, Lindstrom, P G, additional, Bhatia, H, additional, Bremer, P T, additional, Copeland, D M, additional, Chand, K K, additional, Fox, A L, additional, Lloyd, G S, additional, Menon, H, additional, Morrison, G D, additional, Osei-Kuffuor, D, additional, Pinnow, N T, additional, Quinlan, D J, additional, Sanders, G D, additional, Schordan, M, additional, Vanderbruggen, T, additional, Hoang, D, additional, Klacansky, P, additional, Pascucci, V, additional, Usher, W, additional, Lam, M, additional, Moody, L G, additional, Diffenderfer, J D, additional, Metere, A, additional, and Yang, L M, additional

Published
2019
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11. Modern Times.

Author

Bhatia, H. S.

Subjects
SLEEP, BASEMENTS, TOYS
Abstract

The poem "Modern Times" by H. S. Bhatia is presented. First Line: Ripples ride silence; Last Line: that foists a veneer.

Published
2024

12. Momentary Moments.

Author

Bhatia, H. S.

Subjects
DOG barking
Abstract

The poem "Momentary Moments" by H. S. Bhatia is presented. First Line: Nightingale's songs are sweet; Last Line: Turns not to see or seen.

Published
2024

18. Role of large-scale advection and small-scale turbulence on vertical migration of gyrotactic swimmers

Author

Marchioli, C., Bhatia, H., Sardina, G., Brandt, Luca, Soldati, A., Marchioli, C., Bhatia, H., Sardina, G., Brandt, Luca, and Soldati, A.

Abstract

In this work, we use direct-numerical-simulation-based Eulerian-Lagrangian simulations to investigate the dynamics of small gyrotactic swimmers in free-surface turbulence. We consider open-channel flow turbulence in which bottom-heavy swimmers are dispersed. Swimmers are characterized by different vertical stability, so that some realign to swim upward with a characteristic time smaller than the Kolmogorov timescale, while others possess a reorientation time longer than the Kolmogorov timescale. We cover one order of magnitude in the flow Reynolds number and two orders of magnitude in the stability number, which is a measure of bottom heaviness. We observe that large-scale advection dominates vertical motion when the stability number, scaled on the local Kolmogorov timescale of the flow, is larger than unity: This condition is associated to enhanced migration toward the surface, particularly at low Reynolds number, when swimmers can rise through surface renewal motions that originate directly from the bottom-boundary turbulent bursts. Conversely, small-scale effects become more important when the Kolmogorov-based stability number is below unity: Under this condition, migration toward the surface is hindered, particularly at high Reynolds, when bottom-boundary bursts are less effective in bringing bulk fluid to the surface. In an effort to provide scaling arguments to improve predictions of models for motile microorganisms in turbulent water bodies, we demonstrate that a Kolmogorov-based stability number around unity represents a threshold beyond which swimmer capability to reach the free surface and form clusters saturates., QC 20200103

Published
2019
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23. Fetal hydantoin syndrome: A case report

Author

Singh, A., Bhatia, H., Mohan, A., and Sharma, N.

Subjects
Epilepsy, Seizures (Medicine), Phenytoin, Health
Abstract

Byline: A. Singh, H. Bhatia, A. Mohan, N. Sharma Fetal hydantoin syndrome (FHS) is a spectrum of defects caused to the developing fetus by exposure to the teratogenic effects of [...]

Published
2016

33. Study of produced harmonics in DFIG powered by wind turbines over linear and nonlinear loads

Author

Pant Rajesh, Kumar C Vivek, Muhsen Muntadar, Rani D. Sandhya, Vokhidov Akmal, Daminova Barno, and Bhatia Harpreet S.

Subjects
Environmental sciences, GE1-350
Abstract

Due to the growing interest in electricity, both conventional and non-conventional energy sources are growing. As the number of powertrains increases, just as the interconnectivity of these components grows terrifyingly, so does the power response along with the variable overcurrent. Which acquires the majority of power shares in an environmentally responsible manner. One thing that sets wind power apart is how little it costs. With a proven capacity of around 21262 MW, India's wind farm ranks fifth in the world with an exceptionally high annual expansion rate [1]. Management New Harmless to Ecosystem Strength (MNRE) and association of Tamil Nadu, Maharashtra and Gujarat movements. Considering the 7.6 Gw of wind cap that has been produced in the last 15 months, the target is to produce an additional 10 Gw in FY 2019[2]. The Twofold Dealt with Acknowledgement Generator (DFIG) structure was found to be affected by the wind in uneven stacking. The electricity produced makes endless sounds available [3]. The proposed study depicts the evaluation of noise produced by wind-related electricity. The combined dynamic channel uses the DFIG system for both direct and indirect loads. This work recreates the sounds produced by direct and indirect loads using mutt dynamic channel reduction for Grid Side Control (GSC) and Rotor Side Control (RSC). The end product of this effort shows that using the unequal weight system, the value of sounds dropped to 4.96% from 29.66%. Additionally, it shows that in cases where the nonlinear weight has no effect on the structure, the consonant value is exactly 0.14%. Various research projects are now being carried out in an effort to develop channels that can suppress consonant levels higher than the dedicated hybrid feed channel. MATLAB R2018a variant is used to generate the model for the proposed work. The model is shown in the Simulink section of MATLAB under Programming.

Published
2024
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34. Frequency of [beta]-thalassemia trait and other hemoglobinopathies in northern and western India

Author

Madan, Nishi, Sharma, Satendra, Sood, S., Colah, Roshan, and Bhatia, H.

Subjects
Hemoglobinopathy -- Risk factors -- Diagnosis -- Genetic aspects -- Demographic aspects -- Control -- Research, Health, Science and technology
Abstract

Byline: Nishi. Madan, Satendra. Sharma, S. Sood, Roshan. Colah, H. Bhatia Introduction : India is an ethnically diverse country with an approximate population of 1.2 billion. The frequency of beta-thalassemia [...]

Published
2010

42. Validation of Tanaka and Johnston's analysis in western UP Indian population

Author

Srivastava, B., Bhatia, H., Singh, R., Singh, A., Aggarwal, A., and Gupta, N.

Subjects
Elementary school students -- Analysis -- Statistics, Health
Abstract

Byline: B. Srivastava, H. Bhatia, R. Singh, A. Singh, A. Aggarwal, N. Gupta Objective: To examine the applicability of the Tanaka and Johnston's method of prediction in a western UP [...]

Published
2013

43. Woman - A Rose.

Author

Bhatia, H. S.

Subjects
ROSES
Abstract

The poem "Woman - A Rose" by H.S. Bhatia is presented. First Line: A woman is a Rose in bloom; Last Line: woman surely knows better!

Published
2023

44. My Daughter, Girl Child.

Author

Bhatia, H. S.

Subjects
GIRLS, DAUGHTERS
Abstract

The poem "My Daughter, Girl Child" by H.S. Bhatia is presented. First Line: To the old generation, modern children; Last Line: May all the children be like her!

Published
2023

45. Optimize a cascaded cooling water network.

Author

BHATIA, H., GARCIA, C., and NANGIA, K.

Abstract

The article explores ways for optimizing a cascaded cooling water network in hydrocarbon processing plants . Topics include ways in which cascaded cooling water network requires a more elaborate hydraulic analysis due to the combination of a parallel and series-parallel network; and hydraulic model of the network self-adjusts that maintain flow of cooling water into each heat exchanger.

Published
2022

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