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22 results on '"Bhatia, Urvashi"'

6. CD8+ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome

Author

Gross, Catharina C., Meyer, Céline, Bhatia, Urvashi, Yshii, Lidia, Kleffner, Ilka, Bauer, Jan, Tröscher, Anna R., Schulte-Mecklenbeck, Andreas, Herich, Sebastian, Schneider-Hohendorf, Tilman, Plate, Henrike, Kuhlmann, Tanja, Schwaninger, Markus, Brück, Wolfgang, Pawlitzki, Marc, Laplaud, David-Axel, Loussouarn, Delphine, Parratt, John, Barnett, Michael, Buckland, Michael E., Hardy, Todd A., Reddel, Stephen W., Ringelstein, Marius, Dörr, Jan, Wildemann, Brigitte, Kraemer, Markus, Lassmann, Hans, Höftberger, Romana, Beltrán, Eduardo, Dornmair, Klaus, Schwab, Nicholas, Klotz, Luisa, Meuth, Sven G., Martin-Blondel, Guillaume, Wiendl, Heinz, and Liblau, Roland

Published
2019
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7. Neurochondrin is a neuronal target antigen in autoimmune cerebellar degeneration

Author

Miske, Ramona, Gross, Catharina C., Scharf, Madeleine, Golombeck, Kristin S., Hartwig, Marvin, Bhatia, Urvashi, Schulte-Mecklenbeck, Andreas, Bönte, Kathrin, Strippel, Christine, Schöls, Ludger, Synofzik, Matthis, Lohmann, Hubertus, Dettmann, Inga Madeleine, Deppe, Michael, Mindorf, Swantje, Warnecke, Tobias, Denno, Yvonne, Teegen, Bianca, Probst, Christian, Brakopp, Stefanie, Wandinger, Klaus-Peter, Wiendl, Heinz, Stöcker, Winfried, Meuth, Sven G., Komorowski, Lars, and Melzer, Nico

Published
2017
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9. Characterization of T cells in NMOSD patients - an emerging role for T cells in disease pathogenesis (4017)

Author

Lindner, Maren, primary, Bhatia, Urvashi, additional, Schulte-Mecklenbeck, Andreas, additional, Wirth, Timo, additional, Gross, Catharina, additional, Schmidt, Tyge, additional, Korsen, Melanie, additional, Schneider-Hohendorf, Tilman, additional, Schwab, Nicholas, additional, Barman, Sumanta, additional, Aktas, Orhan, additional, Goebels, Norbert, additional, Winkler, Anne, additional, Stadelmann-Nessler, Christine, additional, Brueck, Wolfgang, additional, Kuempfel, Tania, additional, Siebert, Nadja, additional, Paul, Friedemann, additional, Kleiter, Ingo, additional, Wiendl, Heinz, additional, Kuhlmann, Tanja, additional, Ringelstein, Marius, additional, and Klotz, Luisa, additional

Published
2020
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11. Additional file 1: of Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3

Author

Schmidt, Angelika, Marabita, Francesco, Narsis Kiani, Gross, Catharina, Johansson, Henrik, Éliás, Szabolcs, Rautio, Sini, Eriksson, Matilda, Sunjay Fernandes, Silberberg, Gilad, Ubaid Ullah, Bhatia, Urvashi, Lähdesmäki, Harri, Lehtiö, Janne, Gomez-Cabrero, David, Wiendl, Heinz, Lahesmaa, Riitta, and Tegnér, Jesper

Abstract

Figure S1. Flow cytometry and qRT-PCR quality control of cellular samples used for molecular profiling. Figure S2. Differential gene and protein expression analysis and overlap of RNA-Seq and proteomics data. Figure S3. Exploratory analysis of RNA-Seq and proteomics data. Figure S4. Estimated number of proteins per cell based on iTreg proteomics data. Figure S5. Gene Ontology and pathway enrichment analysis of the DEG and DEP clusters. Figure S6. iTreg subnetwork reconstruction strategy. Figure S7. Features of the iTreg candidate molecules and the confirmatory independent RNA-Seq dataset. Figure S8. Linear Discriminant and Random Forest analyses confirm the potential of candidate genes to classify iTregs. Figure S9. Experimental validation of novel FOXP3+ Treg regulatory molecules. (PDF 3722 kb)

Published
2018
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12. Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3

Author

Schmidt, Angelika, primary, Marabita, Francesco, additional, Kiani, Narsis A., additional, Gross, Catharina C., additional, Johansson, Henrik J., additional, Éliás, Szabolcs, additional, Rautio, Sini, additional, Eriksson, Matilda, additional, Fernandes, Sunjay Jude, additional, Silberberg, Gilad, additional, Ullah, Ubaid, additional, Bhatia, Urvashi, additional, Lähdesmäki, Harri, additional, Lehtiö, Janne, additional, Gomez-Cabrero, David, additional, Wiendl, Heinz, additional, Lahesmaa, Riitta, additional, and Tegnér, Jesper, additional

Published
2018
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14. Neurochondrin is a neuronal target antigen in autoimmune cerebellar degeneration

Author

Miske, Ramona, primary, Gross, Catharina C., additional, Scharf, Madeleine, additional, Golombeck, Kristin S., additional, Hartwig, Marvin, additional, Bhatia, Urvashi, additional, Schulte-Mecklenbeck, Andreas, additional, Bönte, Kathrin, additional, Strippel, Christine, additional, Schöls, Ludger, additional, Synofzik, Matthis, additional, Lohmann, Hubertus, additional, Dettmann, Inga Madeleine, additional, Deppe, Michael, additional, Mindorf, Swantje, additional, Warnecke, Tobias, additional, Denno, Yvonne, additional, Teegen, Bianca, additional, Probst, Christian, additional, Brakopp, Stefanie, additional, Wandinger, Klaus-Peter, additional, Wiendl, Heinz, additional, Stöcker, Winfried, additional, Meuth, Sven G., additional, Komorowski, Lars, additional, and Melzer, Nico, additional

Published
2016
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15. Transcriptional Repressor HIC1 Contributes to Suppressive Function of Human Induced Regulatory T Cells.

Author

Ullah, Ubaid, Andrabi, Syed Bilal Ahmad, Tripathi, Subhash Kumar, Dirasantha, Obaiah, Kanduri, Kartiek, Rautio, Sini, Gross, Catharina C., Lehtimäki, Sari, Bala, Kanchan, Tuomisto, Johanna, Bhatia, Urvashi, Chakroborty, Deepankar, Elo, Laura L., Lähdesmäki, Harri, Wiendl, Heinz, Rasool, Omid, and Lahesmaa, Riitta

Abstract

Regulatory T (Treg) cells are critical in regulating the immune response. In vitro induced Treg (iTreg) cells have significant potential in clinical medicine. However, applying iTreg cells as therapeutics is complicated by the poor stability of human iTreg cells and their variable suppressive activity. Therefore, it is important to understand the molecular mechanisms of human iTreg cell specification. We identified hypermethylated in cancer 1 (HIC1) as a transcription factor upregulated early during the differentiation of human iTreg cells. Although FOXP3 expression was unaffected, HIC1 deficiency led to a considerable loss of suppression by iTreg cells with a concomitant increase in the expression of effector T cell associated genes. SNPs linked to several immune-mediated disorders were enriched around HIC1 binding sites, and in vitro binding assays indicated that these SNPs may alter the binding of HIC1. Our results suggest that HIC1 is an important contributor to iTreg cell development and function. [ABSTRACT FROM AUTHOR]

Published
2018
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17. UVB light attenuates the systemic immune response in CNS autoimmunity

Author

Breuer, Johanna, primary, Schwab, Nicholas, additional, Schneider-Hohendorf, Tilman, additional, Marziniak, Martin, additional, Mohan, Hema, additional, Bhatia, Urvashi, additional, Groß, Catharina, additional, Clausen, Björn, additional, Weishaupt, Carsten, additional, Luger, Thomas, additional, Meuth, Sven, additional, Loser, Karin, additional, and Wiendl, Heinz, additional

Published
2014
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21. Graphene nanosheets from hazardous/solid wastes: An efficient CO2capture material

Author

Aquatar, Md. Osim, Mankar, Juili S., Bhatia, Urvashi, Rayalu, Sadhana S., and Krupadam, Reddithota J.

Abstract

Highly efficient CO2capture at elevated temperatures has been achieved with a few-layered graphene nanosheets (GNS) prepared from solid waste generated from high energy explosive materials manufacturing industry. These materials were used to adsorb CO2from simulated industrial flue gases with an aim to reduce CO2concentration in the atmosphere. The GNS is a microporous material with pore volume of 0.59 cm3g−1and 70% of pores were of average size of 0.55 nm. The surface area of GNS was 964 m2g−1which was reduced to 268 m2g−1when the number of layers in GNS increased to >50. The adsorption capacity of 3.89 mmol g−1was achieved at 303 K/0.5 bar and this adsorption capacity was further increased to 23.63 mmol g−1at 303 K/20 bar. The Sips adsorption model was used for evaluating the relationship between surface heterogeneity of GNS and adsorption capacity at temperature. The GNS materials selectively captured CO2in the presence of gases mixtures (CO2/N2and CO2/CH4). The fast adsorption kinetics and recycling stability of GNS for about 20 cycles suggests that the solid adsorbents prepared in this study are efficient and technically feasible to capture CO2from industrial stacks and other real-life situations.

Published
2021
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22. Neurochondrin is a neuronal target antigen in autoimmune cerebellar degeneration.

Author

Miske R, Gross CC, Scharf M, Golombeck KS, Hartwig M, Bhatia U, Schulte-Mecklenbeck A, Bönte K, Strippel C, Schöls L, Synofzik M, Lohmann H, Dettmann IM, Deppe M, Mindorf S, Warnecke T, Denno Y, Teegen B, Probst C, Brakopp S, Wandinger KP, Wiendl H, Stöcker W, Meuth SG, Komorowski L, and Melzer N

Abstract

Objective: To report on a novel neuronal target antigen in 3 patients with autoimmune cerebellar degeneration., Methods: Three patients with subacute to chronic cerebellar ataxia and controls underwent detailed clinical and neuropsychological assessment together with quantitative high-resolution structural MRI. Sera and CSF were subjected to comprehensive autoantibody screening by indirect immunofluorescence assay (IFA) and immunoblot. Immunoprecipitation with lysates of hippocampus and cerebellum combined with mass spectrometric analysis was used to identify the autoantigen, which was verified by recombinant expression in HEK293 cells and use in several immunoassays. Multiparameter flow cytometry was performed on peripheral blood and CSF, and peripheral blood was subjected to T-cell receptor spectratyping., Results: Patients presented with a subacute to chronic cerebellar and brainstem syndrome. MRI was consistent with cortical and cerebellar gray matter atrophy associated with subsequent neuroaxonal degeneration. IFA screening revealed strong immunoglobulin G1 reactivity in sera and CSF with hippocampal and cerebellar molecular and granular layers, but not with a panel of 30 recombinantly expressed established neural autoantigens. Neurochondrin was subsequently identified as the target antigen, verified by IFA and immunoblot with HEK293 cells expressing human neurochondrin as well as the ability of recombinant neurochondrin to neutralize the autoantibodies' tissue reaction. Immune phenotyping revealed intrathecal accumulation and activation of B and T cells during the acute but not chronic phase of the disease. T-cell receptor spectratyping suggested an antigen-specific T-cell response accompanying the formation of antineurochondrin autoantibodies. No such neurochondrin reactivity was found in control cohorts of various neural autoantibody-associated neurologic syndromes, relapsing-remitting multiple sclerosis, cerebellar type of multiple system atrophy, hereditary cerebellar ataxias, other neurologic disorders, or healthy donors., Conclusion: Neurochondrin is a neuronal target antigen in autoimmune cerebellar degeneration.

Published
2016
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