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7. Beyond the Standard Model Physics at the HL-LHC and HE-LHC

Author

Vidal, X. Cid, D'Onofrio, M., Fox, P. J., Torre, R., Ulmer, K. A., Aboubrahim, A., Albert, A., Alimena, J., Allanach, B. C., Alpigiani, C., Altakach, M., Amoroso, S., Anders, J. K., Araz, J. Y., Arbey, A., Azzi, P., Babounikau, I., Baer, H., Baker, M. J., Barducci, D., Barger, V., Baron, O., Navarro, L. Barranco, Battaglia, M., Bay, A., Bhatia, D., Biswas, S., Bloch, D., Bogavac, D., Borschensky, C., Bugge, M. K., Buttazzo, D., Cacciapaglia, G., Cadamuro, L., Calandri, A., Camargo, D. A., Canepa, A., Carminati, L., Carrá, S., Montoya, C. A. Carrillo, De Oliveira, A. Carvalho Antunes, Castillo, F. L., Cavaliere, V., Cavalli, D., Cecchi, C., Celis, A., Cerri, A., Chahal, G. S., Chakraborty, A., Chekanov, S. V., Cheng, H. J., Childers, J. T., Cirelli, M., Colegrove, O., Corcella, G., Corradi, M., Costa, M. J., Covarelli, R., Dang, N. P., Deandrea, A., De Curtis, S., De la Torre, H., Rose, L. Delle, Del Re, D., Demela, A., Demers, S., Dermisek, R., De Santo, A., Deshpande, K., Dey, B., Donini, J., Duncan, A. K., Dutta, V., Escobar, C., Fanó, L., Ferretti, G., Fiaschi, J., Fischer, O., Flacke, T., Frangipane, E. D., Frank, M., Frattari, G., Frizzell, D., Fuchs, E., Fuks, B., Gabrielli, E., Gainer, J., Gao, Y., Navarro, J. E. García, Genest, M. H., Giagu, S., Giudice, G. F., Goh, J., Gouzevitch, M., Govoni, P., Greljo, A., Grohsjean, A., Gurrola, A., Gustavino, G., Guyot, C., Gwilliam, C. B., Ha, S., Haisch, U., Haller, J., Han, T., Hayden, D., Heikinheimo, M., Heintz, U., Helsens, C., Hoepfner, K., Hogan, J. M., Huitu, K., Ilten, P., Ippolito, V., Ismail, A., Iyer, A. M., Jain, Sa., Jamin, D. O., Jeanty, L., Jezo, T., Johns, W., Kalogeropoulos, A., Karancsi, J., Kats, Y., Keller, H., Khanov, A., Kieseler, J., Kim, B., Kim, M. S., Kim, Y. G., Klasen, M., Klimek, M. D., Kogler, R., Komaragiri, J. R., Krämer, M., Kubota, S., Kulesza, A. K., Kulkarni, S., Lari, T., Ledovskoy, A., Lee, G. R., Lee, L., Lee, S. W., Leonardi, R., Les, R., Lewis, I. M., Li, Q., Li, T., Lim, I. T., Lim, S. H., Lin, K., Liu, Z., Long, K., Low, M., Lunghi, E., Madaffari, D., Mahmoudi, F., Majumder, D., Malvezzi, S., Mangano, M. L., Manoni, E., Marcano, X., Mariotti, A., Marjanovic, M., Marlow, D., Camalich, J. Martin, Cuevas, P. Matorras, McCullough, M., McDonald, E. F., Guisao, J. Mejia, Mele, B., Meloni, F., Melzer-Pellmann, I. -A., Merlassino, C., Meyer, A. B., Michielin, E., Miller, A. J., Mittnacht, L., Mondal, S., Moretti, S., Mukhopadhyay, S., Nachman, B. P., Nam, K., Narain, M., Nardecchia, M., Nath, P., Navarro-González, J., Nisati, A., Nitta, T., Noel, D. L., Nojiri, M. M., Ochoa-Ricoux, J. P., Oide, H., Ojeda, M. L., Griso, S. Pagan, Cortezon, E. Palencia, Panella, O., Pani, P., Panizzi, L., Panwar, L., Park, C. B., Pazzini, J., Pedro, K., Perego, M. M., Perrozzi, L., Petersen, B. A., Pierce, A., Polesello, G., Policicchio, A., Potter, C. J., Pralavorio, P., Presilla, M., Proudfoot, J., Queiroz, F. S., Ramirez-Sanchez, G., Redigolo, D., Reimers, A., Resconi, S., Rimoldi, M., Vergara, J. C. Rivera, Rizzo, T., Rogan, C., Romeo, F., Rosten, R., Ruiz, R., Ruiz-Alvarez, J., Iglesias, J. A. Sabater, Samani, B. Safarzadeh, Sagir, S., Saito, M., Saito, S., Sala, F., Salazar, C., Savin, A., Sawada, R., Sawant, S., Schienbein, I., Schlaffer, M., Schneider, B., Schuler, S. C., Sebastiani, C. D., Sekmen, S., Selvaggi, M., Sengupta, D., Serce, H., Serodio, H., Sestini, L., Shakya, B., Haghi, B. Shams Es, Sheldon, P., Shin, S., Simonetto, F., Soffi, L., Spannowsky, M., Stupak, J., Sullivan, M. J., Sunder, M., Takahashi, Y., Tata, X., Teagle, H., Terashi, K., Tesi, A., Thamm, A., Tobioka, K., Tornambe, P., Trovato, F., Tsiakkouri, D., Ungaro, F. C., Urbano, A., Usai, E., Vanegas, N., Vaslin, L., Sierra, C. Vázquez, Vivarelli, I., Milosavljevic, M. Vranjes, Waltari, H., Wang, R., Wang, X., Weber, M. S., Weiland, C., Wielers, M., Williams, J. M., Willocq, S., Xu, D., Yagyu, K., Yazgan, E., Ye, R., Yoo, H. D., You, T., Yu, F., Della Porta, G. Zevi, Zhang, W., Zhu, C., Zhuang, X., Zobec, J., Zupan, J., and Zurita, J.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract

This is the third out of five chapters of the final report [1] of the Workshop on Physics at HL-LHC, and perspectives on HE-LHC [2]. It is devoted to the study of the potential, in the search for Beyond the Standard Model (BSM) physics, of the High Luminosity (HL) phase of the LHC, defined as $3~\mathrm{ab}^{-1}$ of data taken at a centre-of-mass energy of $14~\mathrm{TeV}$, and of a possible future upgrade, the High Energy (HE) LHC, defined as $15~\mathrm{ab}^{-1}$ of data at a centre-of-mass energy of $27~\mathrm{TeV}$. We consider a large variety of new physics models, both in a simplified model fashion and in a more model-dependent one. A long list of contributions from the theory and experimental (ATLAS, CMS, LHCb) communities have been collected and merged together to give a complete, wide, and consistent view of future prospects for BSM physics at the considered colliders. On top of the usual standard candles, such as supersymmetric simplified models and resonances, considered for the evaluation of future collider potentials, this report contains results on dark matter and dark sectors, long lived particles, leptoquarks, sterile neutrinos, axion-like particles, heavy scalars, vector-like quarks, and more. Particular attention is placed, especially in the study of the HL-LHC prospects, to the detector upgrades, the assessment of the future systematic uncertainties, and new experimental techniques. The general conclusion is that the HL-LHC, on top of allowing to extend the present LHC mass and coupling reach by $20-50\%$ on most new physics scenarios, will also be able to constrain, and potentially discover, new physics that is presently unconstrained. Moreover, compared to the HL-LHC, the reach in most observables will generally more than double at the HE-LHC, which may represent a good candidate future facility for a final test of TeV-scale new physics., Comment: Report from Working Group 3 on the Physics of the HL-LHC, and Perspectives at the HE-LHC; v2: final version updated with the latest contributions and summaries; 239 pages + refs; v3: typos and character misprint in Fig. 7.2 fixed; v4: added one missing author

Published
2018

8. Les Houches 2017: Physics at TeV Colliders Standard Model Working Group Report

Author

Bendavid, J., Caola, F., Ciulli, V., Harlander, R., Heinrich, G., Huston, J., Kallweit, S., Prestel, S., Re, E., Tackmann, K., Thaler, J., Theofilatos, K., Andersen, J. R., Bellm, J., Berger, N., Bhatia, D., Biedermann, B., Bräuer, S., Britzger, D., Buckley, A. G., Camacho, R., Chachamis, G., Chatterjee, S., Chen, X., Chiesa, M., Currie, J. R., Denner, A., Dreyer, F., Driencourt-Mangin, F., Forte, S., Garzelli, M. V., Gehrmann, T., Gieseke, S., Glover, E. W. N., Gras, P., Greiner, N., Gütschow, C., Gwenlan, C., Heil, M., Herndon, M., Hirschi, V., Hoang, A. H., Höche, S., Huss, A., Jones, S. P., Kar, D., Karlberg, A., Kassabov, Z., Kerner, M., Klappert, J., Kuttimalai, S., Lang, J. -N., Larkoski, A., Lindert, J. M., Loch, P., Long, K., Lönnblad, L., Luisoni, G., Maier, A., Maierhöfer, P., Maître, D., Marzani, S., McFayden, J. A., Moult, I., Mozer, M., Mrenna, S., Nachman, B., Napoletano, D., Pandini, C., Papaefstathiou, A., Pellen, M., Perrozzi, L., Pires, J., Plätzer, S., Pozzorini, S., Quackenbush, S., Rabbertz, K., Rauch, M., Reuschle, C., Richardson, P., Ridder, A. Gehrmann-De, Rodrigo, G., Rojo, J., Röntsch, R., Rottoli, L., Samitz, D., Samui, T., Sborlini, G., Schönherr, M., Schumann, S., Scyboz, L., Seth, S., Shao, H. -S., Siódmok, A., Skands, P. Z., Smillie, J. M., Soyez, G., Sun, P., Sutton, M. R., Tackmann, F. J., Uccirati, S., Weinzierl, S., Yazgan, E., Yuan, C. -P., and Yuan, F.

Subjects
High Energy Physics - Phenomenology
Abstract

This Report summarizes the proceedings of the 2017 Les Houches workshop on Physics at TeV Colliders. Session 1 dealt with (I) new developments relevant for high precision Standard Model calculations, (II) theoretical uncertainties and dataset dependence of parton distribution functions, (III) new developments in jet substructure techniques, (IV) issues in the theoretical description of the production of Standard Model Higgs bosons and how to relate experimental measurements, (V) phenomenological studies essential for comparing LHC data from Run II with theoretical predictions and projections for future measurements, and (VI) new developments in Monte Carlo event generators., Comment: Proceedings of the Standard Model Working Group of the 2017 Les Houches Workshop, Physics at TeV Colliders, Les Houches 5-23 June 2017. 314 pages

Published
2018

9. Dissecting Multi-Photon Resonances at the Large Hadron Collider

Author

Allanach, B. C., Bhatia, D., and Iyer, A. M.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract

We examine the phenomenology of the production, at the 13 TeV Large Hadron Collider (LHC), of a heavy resonance $X$, which decays via other new on-shell particles $n$ into multi- (i.e.\ three or more) photon final states. In the limit that $n$ has a much smaller mass than $X$, the multi-photon final state may dominantly appear as a two photon final state because the $\gamma$s from the $n$ decay are highly collinear and remain unresolved. We discuss how to discriminate this scenario from $X \rightarrow \gamma \gamma$: rather than discarding non-isolated photons, it is better instead to relax the isolation criterion and instead form photon jet substructure variables. The spins of $X$ and $n$ leave their imprint upon the distribution of pseudorapidity gap $\Delta \eta$ between the apparent two photon states. Depending on the total integrated luminosity, this can be used in many cases to claim discrimination between the possible spin choices of $X$ and $n$, although the case where $X$ and $n$ are both scalar particles cannot be discriminated from the direct $X \rightarrow \gamma \gamma$ decay in this manner. Information on the mass of $n$ can be gained by considering the mass of each photon jet., Comment: 26 pages, 7 figures. v2 incorporates extra discussion in response to referee and a discussion of photon conversion

Published
2017
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10. Beyond the Standard Model Physics at the HL-LHC and HE-LHC

Author

Vidal, X Cid, D'Onofrio, M, Fox, PJ, Torre, R, Ulmer, KA, Aboubrahim, A, Albert, A, Alimena, J, Allanach, BC, Alpigiani, C, Altakach, M, Amoroso, S, Anders, JK, Araz, JY, Arbey, A, Azzi, P, Babounikau, I, Baer, H, Baker, MJ, Barducci, D, Barger, V, Baron, O, Navarro, L Barranco, Battaglia, M, Bay, A, Bhatia, D, Biswas, S, Bloch, D, Bogavac, D, Borschensky, C, Bugge, MK, Buttazzo, D, Cacciapaglia, G, Cadamuro, L, Calandri, A, Camargo, DA, Canepa, A, Carminati, L, Carrá, S, Montoya, CA Carrillo, Oliveira, A Carvalho Antunes De, Castillo, FL, Cavaliere, V, Cavalli, D, Cecchi, C, Celis, A, Cerri, A, Chahal, GS, Chakraborty, A, Chekanov, SV, Cheng, HJ, Childers, JT, Cirelli, M, Colegrove, O, Corcella, G, Corradi, M, Costa, MJ, Covarelli, R, Dang, NP, Deandrea, A, Curtis, S De, Torre, H De la, Rose, L Delle, Re, D Del, Demela, A, Demers, S, Dermisek, R, Santo, A De, Deshpande, K, Dey, B, Donini, J, Duncan, AK, Dutta, V, Escobar, C, Fanó, L, Ferretti, G, Fiaschi, J, Fischer, O, Flacke, T, Frangipane, ED, Frank, M, Frattari, G, Frizzell, D, Fuchs, E, Fuks, B, Gabrielli, E, Gainer, J, Gao, Y, Navarro, JE García, Genest, MH, Giagu, S, Giudice, GF, Goh, J, Gouzevitch, M, Govoni, P, Greljo, A, Grohsjean, A, Gurrola, A, Gustavino, G, and Guyot, C

Subjects
hep-ph, hep-ex
Abstract

This is the third out of five chapters of the final report [1] of theWorkshop on Physics at HL-LHC, and perspectives on HE-LHC [2]. It is devoted tothe study of the potential, in the search for Beyond the Standard Model (BSM)physics, of the High Luminosity (HL) phase of the LHC, defined as$3~\mathrm{ab}^{-1}$ of data taken at a centre-of-mass energy of$14~\mathrm{TeV}$, and of a possible future upgrade, the High Energy (HE) LHC,defined as $15~\mathrm{ab}^{-1}$ of data at a centre-of-mass energy of$27~\mathrm{TeV}$. We consider a large variety of new physics models, both in asimplified model fashion and in a more model-dependent one. A long list ofcontributions from the theory and experimental (ATLAS, CMS, LHCb) communitieshave been collected and merged together to give a complete, wide, andconsistent view of future prospects for BSM physics at the consideredcolliders. On top of the usual standard candles, such as supersymmetricsimplified models and resonances, considered for the evaluation of futurecollider potentials, this report contains results on dark matter and darksectors, long lived particles, leptoquarks, sterile neutrinos, axion-likeparticles, heavy scalars, vector-like quarks, and more. Particular attention isplaced, especially in the study of the HL-LHC prospects, to the detectorupgrades, the assessment of the future systematic uncertainties, and newexperimental techniques. The general conclusion is that the HL-LHC, on top ofallowing to extend the present LHC mass and coupling reach by $20-50\%$ on mostnew physics scenarios, will also be able to constrain, and potentiallydiscover, new physics that is presently unconstrained. Moreover, compared tothe HL-LHC, the reach in most observables will generally more than double atthe HE-LHC, which may represent a good candidate future facility for a finaltest of TeV-scale new physics.

Published
2018

11. Les Houches 2017: Physics at TeV Colliders Standard Model Working Group Report

Author

Bendavid, J, Caola, F, Ciulli, V, Harlander, R, Heinrich, G, Huston, J, Kallweit, S, Prestel, S, Re, E, Tackmann, K, Thaler, J, Theofilatos, K, Andersen, JR, Bellm, J, Berger, N, Bhatia, D, Biedermann, B, Bräuer, S, Britzger, D, Buckley, AG, Camacho, R, Chachamis, G, Chatterjee, S, Chen, X, Chiesa, M, Currie, JR, Denner, A, Dreyer, F, Driencourt-Mangin, F, Forte, S, Garzelli, MV, Gehrmann, T, Gieseke, S, Glover, EWN, Gras, P, Greiner, N, Gütschow, C, Gwenlan, C, Heil, M, Herndon, M, Hirschi, V, Hoang, AH, Höche, S, Huss, A, Jones, SP, Kar, D, Karlberg, A, Kassabov, Z, Kerner, M, Klappert, J, Kuttimalai, S, Lang, J-N, Larkoski, A, Lindert, JM, Loch, P, Long, K, Lönnblad, L, Luisoni, G, Maier, A, Maierhöfer, P, Maître, D, Marzani, S, McFayden, JA, Moult, I, Mozer, M, Mrenna, S, Nachman, B, Napoletano, D, Pandini, C, Papaefstathiou, A, Pellen, M, Perrozzi, L, Pires, J, Plätzer, S, Pozzorini, S, Quackenbush, S, Rabbertz, K, Rauch, M, Reuschle, C, Richardson, P, Ridder, A Gehrmann-De, Rodrigo, G, Rojo, J, Röntsch, R, Rottoli, L, Samitz, D, Samui, T, Sborlini, G, Schönherr, M, Schumann, S, Scyboz, L, Seth, S, Shao, H-S, Siódmok, A, Skands, PZ, Smillie, JM, Soyez, G, Sun, P, Sutton, MR, and Tackmann, FJ

Subjects
hep-ph
Abstract

This Report summarizes the proceedings of the 2017 Les Houches workshop onPhysics at TeV Colliders. Session 1 dealt with (I) new developments relevantfor high precision Standard Model calculations, (II) theoretical uncertaintiesand dataset dependence of parton distribution functions, (III) new developmentsin jet substructure techniques, (IV) issues in the theoretical description ofthe production of Standard Model Higgs bosons and how to relate experimentalmeasurements, (V) phenomenological studies essential for comparing LHC datafrom Run II with theoretical predictions and projections for futuremeasurements, and (VI) new developments in Monte Carlo event generators.

Published
2018

12. Real-World Anti-Vascular Endothelial Growth Factor Therapy Outcomes in Myopic Choroidal Neovascularization

Author

Bhatia D, Mehta A, DaCosta J, Crothers O, and Talks JS

Subjects
myopia, pathological myopia, choroidal neovascularization, anti-vegf intravitreal injection, Ophthalmology, RE1-994
Abstract

Devangna Bhatia, Alexander Mehta, Joanna DaCosta, Oonagh Crothers, James Stephen Talks Newcastle Eye Centre, Royal Victoria Infirmary, Newcastle upon Tyne, UKCorrespondence: Devangna BhatiaNewcastle Eye Centre, Royal Victoria Infirmary, Newcastle upon Tyne, UKEmail Devangna88@gmail.comAim: Evaluation of real-world outcomes of intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy in the primary treatment of choroidal neovascularization (CNV) secondary to pathological myopia.Patients and Methods: A retrospective cohort analysis of treatment naive patients with myopic CNV who received treatment with either intravitreal ranibizumab or aflibercept over a 12-year period from September 2007 to May 2020 was performed. Baseline features, treatment factors and outcomes were compared between younger and older patients and final visual outcome was assessed for associated factors.Results: Thirty-seven eyes of 36 patients (24 females, 12 males) were included. Mean age was 58 years (range=26– 89 years). Of these patients, 11/36 (31%) were ≤ 50 years of age and 25/36 (69%) were ≥ 51 years of age. Seventy-three percent (27/37) of eyes were phakic. One patient received bilateral treatment for myopic CNV. Median spherical equivalent was − 8.50 diopters. Seventy percent (26/37) of eyes commenced primary treatment with ranibizumab, and 11/37 (30%) eyes commenced treatment with aflibercept. There were no significant differences between treatment factors and outcomes of younger and older patients. Median number of injections was 3 over a median follow-up period of 24.6 months. Mean CRT decreased by 126μm and median visual improvement was +6 letters. Analysis showed that younger age (p=0.022) and fewer injections (p=0.004) were associated with better visual outcomes.Conclusion: Myopic CNV requires less frequent anti-VEGF intravitreal therapy over a shorter follow-up period than both neovascular age-related macular degeneration and diabetic macular edema. Increased frequency of administration of intravitreal anti-VEGF treatment did not improve vision. Younger age is associated with a better final visual outcome. These findings may help to advise patients about the prognosis of treatment and help guide treatment decisions.Keywords: myopia, pathological myopia, choroidal neovascularization, anti-VEGF intravitreal injection

Published
2021

15. IMPACT OF SEASONAL FLUCTUATIONS AND ANTHROPOGENIC INTERVENTIONS ON PHYSICOCHEMICAL CHARACTERISTICS OF RIVER MANDAKINI AT DISTRICT RUDRAPRAYAG, UTTARAKHAND.

Author

Semwal, Nikita, Tripathi, D. M., Bahuguna, Pankaj, Bijlwan, Kamal, Bhatia, D. K., and Rayal, Rajesh

Subjects
TOTAL suspended solids, BIOCHEMICAL oxygen demand, DRINKING water, WATER quality, WATER pollution, CHEMICAL oxygen demand
Abstract

The climate changes impact the surface water quality fed by the glaciers of high altitude throughout the world. Consistent increase in water pollution is observed mainly by rapid industrialization, extreme use of fertilizers to fulfill the ever-growing food demand, urbanization, and other anthropogenic activities. River Mandakini in Kedarnath Valley has not been scientifically studied till date in a composite manner. Hence, we collected water samples from Chandrapuri, Agastyamuni, and Tilwara in seasons such as summer, rainy, and winter. Various water quality parameters like temperature, pH, DO (dissolved oxygen), BOD (biochemical oxygen demand), COD (chemical oxygen demand), TDS (total dissolved solids) and TSS (total suspended solids) of all the samples collected were studied. The results of all these physicochemical parameters of river water have shown a considerable decrease compared with the standard values of BIS. The deteriorated water quality of the river poses potential health hazards to people using this water for drinking purposes and aquatic beings residing in the Ganga River. The findings of the present study reflect an overall decline in the water quality of the river and warn of its uses to human beings and the biotic community of the Ganga River. [ABSTRACT FROM AUTHOR]

Published
2024
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16. 2D/3D Liver Segmentation from CT Datasets

Author

Mourya, G. K., Bhatia, D., Handique, A., Warjri, S., War, A., Amir, S. A., Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Ruediger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Bera, Rabindranath, editor, Sarkar, Subir Kumar, editor, and Chakraborty, Swastika, editor

Published
2018
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18. Dexmedetomidine and Propofol Sedation in Critically Ill Patients and Dose-associated 90-Day Mortality: A Secondary Cohort Analysis of a Randomized Controlled Trial (SPICE III)

Author

Shehabi, Yahya, primary, Serpa Neto, Ary, additional, Bellomo, Rinaldo, additional, Howe, Belinda D., additional, Arabi, Yaseen M., additional, Bailey, Michael, additional, Bass, Frances E., additional, Bin Kadiman, Suhaini, additional, McArthur, Colin J., additional, Reade, Michael C., additional, Seppelt, Ian M., additional, Takala, Jukka, additional, Wise, Matt P., additional, Webb, Steve A., additional, Mashonganyika, C., additional, McKee, H., additional, Tonks, A., additional, Donnelly, A., additional, Hemmings, N., additional, O’Kane, S., additional, Blakemore, A., additional, Butler, M., additional, Cowdrey, K., additional, Dalton, J., additional, Gilder, E., additional, Long, S., additional, McCarthy, L., additional, McGuinness, S., additional, Parke, R., additional, Chen, Y., additional, McArthur, C., additional, McConnochie, R., additional, Newby, L., additional, Bellomo, R., additional, Eastwood, G., additional, Peck, L., additional, Young, H., additional, Boschert, C., additional, Edington, J., additional, Fletcher, J., additional, Smith, J., additional, Nand, K., additional, Raza, A., additional, Sara, T., additional, Bennett-Britton, J., additional, Bewley, J., additional, Bodenham, V., additional, Cole, L., additional, Driver, K., additional, Grimmer, L., additional, Howie, L., additional, Searles, C., additional, Sweet, K., additional, Webster, D., additional, van Berkel, A., additional, Connor, H., additional, Dennett, J., additional, van Der Graaff, M., additional, Henderson, S., additional, Mehrtens, J., additional, Miller, K., additional, Minto, E., additional, Morris, A., additional, Noble, S., additional, Parker, K., additional, Bulfin, L., additional, Hart, N., additional, Shepherd, K., additional, Vij, S., additional, Dickson, S., additional, Elloway, E., additional, Ferguson, C., additional, Jackson, R., additional, MacNaughton, P., additional, Marner, M., additional, Squire, R., additional, Waddy, S., additional, Wafer, P., additional, Welbourne, J., additional, Ashcroft, P., additional, Chambler, D., additional, Dukes, S., additional, Harris, A., additional, Horton, S., additional, Sharpe, S., additional, Williams, P., additional, Williams, S., additional, Bailey, M., additional, Blazquez, E., additional, France, D., additional, Hutchison, R., additional, O’Connor, A., additional, Comadira, G., additional, Gough, M., additional, Tallott, M., additional, Bastick, M., additional, Cameron, R., additional, Donovan, S., additional, Ellis, K., additional, Gaur, A., additional, Gregory, R., additional, Naumoff, J., additional, Turner, E., additional, White, M., additional, Au, K. F. J., additional, Fratzia, J., additional, Treloar, S., additional, Lim, C. H., additional, Maseeda, Y., additional, Tan, A. P., additional, Tang, C. L., additional, Yong, C. Y., additional, Akaltan, M., additional, Berger, S., additional, Blaser, D., additional, Fazlija, L., additional, Jong, M. L., additional, Lensch, M., additional, Ludwig, R., additional, Merz, T., additional, Nettelbeck, K., additional, Roth, M., additional, Schafer, M., additional, Takala, J., additional, Wehr, A., additional, Zacharias, D., additional, Amran, R., additional, Ashraf, H. N., additional, Azmi, N., additional, Basri, N., additional, Burhanuddin, H., additional, Hadinata, Y., additional, Hamdan, A., additional, Kadiman, S., additional, Rashid, A. I. Y. M., additional, Sabran, I. N., additional, Sulaiman, S., additional, Zabidi, I. N., additional, Al-Dawood, A., additional, Aljuaid, M., additional, Anizi, H. Al, additional, Saeedi, A. Al, additional, Arabi, Y., additional, Dbsawy, M., additional, Deeb, A., additional, Hegazy, M., additional, Magdi, I., additional, Clarey, E., additional, Corcoran, E., additional, Finney, C., additional, Harris, C., additional, Hopkins, P., additional, Noble, H., additional, Thompson, L., additional, Williams, T., additional, Dumlao, L. A., additional, Bassam, R., additional, Hassan, M. A., additional, Naseem, N., additional, Al-Kurdi, M. H., additional, Al-Harthy, A. M., additional, Bernard, S., additional, Sebafundi, L., additional, Serban, C., additional, Lim, S. K., additional, Mazidah, N., additional, Saidin, N., additional, Sjamsuddin, N., additional, Tan, I. T. A., additional, Zabidi, N., additional, Brain, M., additional, Mineall, S., additional, Kanhere, M., additional, Soar, N., additional, Kadir, N. Abd, additional, Abdullah, N. H., additional, Awang, R., additional, Emperan, Z., additional, Husin, N. S., additional, Ismail, N. I., additional, Ismail, S. Z., additional, Khadzali, F. N. A. Mohd, additional, Norddin, M. F., additional, Aguila, J., additional, Bold, C., additional, Clatworthy, B., additional, Dias, A., additional, Hogan, C., additional, Kazemi, A., additional, Lai, V., additional, Song, R., additional, Williams, A., additional, Bhatia, D., additional, Elliot, S., additional, Galt, P., additional, Lavrans, K., additional, Ritchie, P., additional, Wang, A., additional, Gresham, R., additional, Lowrey, J., additional, Masters, K., additional, Palejs, P., additional, Seppelt, I., additional, Symonds, F., additional, Weisbrodt, L., additional, Whitehead, C., additional, Babio-Galan, M., additional, Calder, V., additional, Clement, I., additional, Harrison, A., additional, McCullagh, I., additional, Scott, C., additional, Bevan, R., additional, Caniba, S., additional, Hacking, D., additional, Maher, L., additional, Azzolini, M. L., additional, Beccaria, P., additional, Colombo, S., additional, Landoni, G., additional, Leggieri, C., additional, Luca, C., additional, Mamo, D., additional, Moizo, E., additional, Monti, G., additional, Mucci, M., additional, Zangrillo, A., additional, Albania, M., additional, Arora, S., additional, Shi, Y., additional, Abudayah, A., additional, Almekhlafi, G., additional, Al Amodi, E., additional, Al Samarrai, S., additional, Badawi, M., additional, Caba, R. Cubio, additional, Elffaki, O., additional, Mandourah, Y., additional, Valerio, J., additional, Joyce, C., additional, Meyer, J., additional, Saylor, E., additional, Venkatesh, B., additional, Venz, E., additional, Walsham, J., additional, Wetzig, K., additional, Khoo, T. M., additional, Liew, J. E. S., additional, Sakthi, A. N., additional, Zulkurnain, A., additional, Bamford, A., additional, Bergin, C., additional, Carrera, R., additional, Cooper, L., additional, Despy, L., additional, Harkett, S., additional, Mee, L., additional, Reeves, E., additional, Snelson, C., additional, Spruce, E., additional, Cooper, G., additional, Hodgson, R., additional, Pearson, D., additional, Rosbergen, M., additional, Ali, M. N., additional, Bahar, N. I., additional, Ismail, A., additional, Ismail, W. N. W., additional, Samat, N. M., additional, Piah, N. S. M., additional, Rahman, R. Abd, additional, Duroux, M., additional, Ratcliffe, M., additional, Warhurst, T., additional, Buehner, U., additional, Williams, E., additional, Jacques, N., additional, Keating, L., additional, Macgill, S., additional, Tamang, K. L., additional, Tolan, N., additional, Walden, A., additional, Bower, R., additional, Cranshaw, J., additional, Molloy, K., additional, Pitts, S., additional, Butler, J., additional, Dunlop, R., additional, Fourie, C., additional, Jarrett, P., additional, Lassig-Smith, M., additional, Livermore, A., additional, O’Donoghue, S., additional, Reade, M., additional, Starr, T., additional, Stuart, J., additional, Campbell, L., additional, Phillips, M., additional, Stephens, D., additional, Thomas, J., additional, Cooper, D., additional, McAllister, R., additional, Andrew, G., additional, Barclay, L., additional, Dawson, H., additional, Griffith, D. M., additional, Hope, D., additional, Wojcik, G., additional, McCulloch, C., additional, Paterson, R., additional, Ascough, L., additional, Paisley, C., additional, Patrick-Heselton, J., additional, Shaw, D., additional, Waugh, V., additional, Williams, K., additional, Welters, I., additional, Barge, D., additional, Jordan, A., additional, MacIsaac, C., additional, Rechnitzer, T., additional, Bass, F., additional, Gatward, J., additional, Hammond, N., additional, Janin, P., additional, Stedman, W., additional, Yarad, E., additional, Razak, N. A., additional, Dzulkipli, N., additional, Jong, S. L., additional, Asen, K., additional, Voon, W. L., additional, Liew, S., additional, Ball, J., additional, Barnes, V., additional, Dalton, C., additional, Farnell-Ward, S., additional, Farrah, H., additional, Maher, K., additional, Mellinghoff, J., additional, Ryan, C., additional, Shirley, P., additional, Conlon, L., additional, Glover, A., additional, Martin-Loeches, I., additional, O’Toole, E., additional, Ewan, J., additional, Ferrier, J., additional, Litton, E., additional, Webb, S. A., additional, Berry, W., additional, Blanco Alonso, U., additional, Bociek, A., additional, Campos, S., additional, Jawara, S., additional, Hanks, F., additional, Kelly, A., additional, Lei, K., additional, McKenzie, C., additional, Ostermann, M., additional, Wan, R., additional, Al-Soufi, S., additional, Leow, S., additional, McCann, K., additional, Reynolds, C., additional, Brickell, K., additional, Fahey, C., additional, Hays, L., additional, Hyde, N., additional, Nichol, A., additional, Ryan, D., additional, Brailsford, J., additional, Buckley, A., additional, Forbes, L., additional, Maguire, T., additional, Moore, J., additional, Murray, L., additional, Ghosh, A., additional, Park, M., additional, Said, S., additional, Visser, A., additional, Abidin, H. Z., additional, Ali, S., additional, Hassan, M. H., additional, Omar, S. C., additional, Shukeri, W. F. W., additional, Brealey, D., additional, Bercades, G., additional, Blackburn, E., additional, Macallum, N., additional, Macklin, A., additional, Ryu, J. H., additional, Tam, K., additional, Smyth, D., additional, Arif, A., additional, Bassford, C., additional, Morgan, C., additional, Swann, C., additional, Ward, G., additional, Wild, L., additional, Bone, A., additional, Elderkin, T., additional, Green, D., additional, Sach, D., additional, Salerno, T., additional, Simpson, N., additional, Brohi, F., additional, Clark, M., additional, Williams, L., additional, Brooks, J., additional, Cocks, E., additional, Cole, J., additional, Curtin, J., additional, Davies, R., additional, Hill, H., additional, Morgan, M., additional, Palmer, N., additional, Whitton, C., additional, Wise, M., additional, Baskaran, P., additional, Hasan, M. S., additional, Tham, L. Y., additional, Sol Cruz, R., additional, Dinsdale, D., additional, Edney, S., additional, Firkin, C., additional, FitzJohn, F., additional, Hill, G., additional, Hunt, A., additional, Hurford, S., additional, Jones, G., additional, Judd, H., additional, Latimer-Bell, C., additional, Lawrence, C., additional, Lesona, E., additional, Navarra, L., additional, Robertson, Y., additional, Smellie, H., additional, Vucago, A. M., additional, Young, P., additional, Clark, P., additional, Kong, J., additional, Ho, J., additional, Nayyar, V., additional, and Skelly, C., additional

Published
2023
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20. Improving the efficiency of wheat breeding experiments using alpha lattice design over randomised complete block design

Author

Kumar, A., Bharti, B., Kumar, J., Bhatia, D., Singh, G. P., Jaiswal, J. P., and Prasad, R.

Abstract

Wheat breeders frequently evaluate large numbers of germplasm and segregating populations for selection in field trials. For testing large number of germplasms under complete block design not much suitable because their assumption to accommodate all the treatment combination in each block that increase the size of experiment and reduce the accuracy. To avoid this constraint the present experiment was designed with objective to realise the suitability of alpha lattice design (ALD) over randomised complete block design (RCBD) in plant breeding experiments. The present experiment was conducted in ALD of 8?×?20 i.e. eight blocks each with 20 genotypes in two replications under rainfed and restricted irrigated conditions to estimate the drought tolerance indices. Nine drought tolerance indices were estimated using the data of rainfed and restricted irrigated conditions. These drought tolerance indices were subjected to analysis of variances of both the designs ALD and RCBD to know the efficiency of ALD over RCBD. The relative efficiency of trials shows that ALD was more efficient than RCB design. Based on grain yield per plant under both the conditions twenty-one tolerant genotypes and eleven susceptible genotypes were identified. Identified tolerant and susceptible genotypes can be used for development of mapping populations and for QTLs mapping programme for drought tolerance in wheat (Triticum aestivumL.).

Published
2024
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23. Genetic mapping of QTLs for drought tolerance in chickpea (Cicer arietinum L.)

Author

Kushwah, A., Bhatia, D., Barmukh, R., Singh, I., Singh, G., Bindra, S., Vij, S., Chellapilla, B., Pratap, A., Roorkiwal, M., Kumar, S., Varshney, R.K., Singh, S., Kushwah, A., Bhatia, D., Barmukh, R., Singh, I., Singh, G., Bindra, S., Vij, S., Chellapilla, B., Pratap, A., Roorkiwal, M., Kumar, S., Varshney, R.K., and Singh, S.

Abstract

Chickpea yield is severely affected by drought stress, which is a complex quantitative trait regulated by multiple small-effect genes. Identifying genomic regions associated with drought tolerance component traits may increase our understanding of drought tolerance mechanisms and assist in the development of drought-tolerant varieties. Here, a total of 187 F8 recombinant inbred lines (RILs) developed from an interspecific cross between drought-tolerant genotype GPF 2 (Cicer arietinum) and drought-sensitive accession ILWC 292 (C. reticulatum) were evaluated to identify quantitative trait loci (QTLs) associated with drought tolerance component traits. A total of 21 traits, including 12 morpho-physiological traits and nine root-related traits, were studied under rainfed and irrigated conditions. Composite interval mapping identified 31 QTLs at Ludhiana and 23 QTLs at Faridkot locations for morphological and physiological traits, and seven QTLs were identified for root-related traits. QTL analysis identified eight consensus QTLs for six traits and five QTL clusters containing QTLs for multiple traits on linkage groups CaLG04 and CaLG06. The identified major QTLs and genomic regions associated with drought tolerance component traits can be introgressed into elite cultivars using genomics-assisted breeding to enhance drought tolerance in chickpea.

Published
2022

30. GADD45α-targeted suicide gene therapy driven by synthetic CArG promoter E9NS sensitizes NSCLC cells to cisplatin, resveratrol, and radiation regardless of p53 status

Author

Shi Q, Sutariya V, Varghese Gupta S, and Bhatia D

Subjects
CArG element, inducible promoter, apoptosis, GADD45α, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, gene therapy, lcsh:RC254-282
Abstract

Qiwen Shi,1 Vijaykumar Sutariya,2 Sheeba Varghese Gupta,2 Deepak Bhatia31Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, Zhejiang, People’s Republic of China; 2College of Pharmacy, University of South Florida, Tampa, FL, USA; 3Bernard J. Dunn School of Pharmacy, Shenandoah University, Ashburn, VA, USABackground: GADD45α is a tumor suppressor protein often upregulated by environmental stresses and DNA-damage agents to cause growth arrest, apoptosis, tumor growth inhibition, and anti-angiogenesis. A novel suicide gene therapy vector pE9NS.G45α was engineered by cloning GADD45α opening reading frame downstream to the synthetic CArG promoter E9NS, which contains nine repeats of CArG element with modified core A/T sequence and functions as a molecular switch to drive the expression of GADD45α. The current study aims to determine the efficacy of this suicide gene therapy vector in combination with cisplatin, resveratrol, and radiation in NSCLC cell lines with various p53 statuses.Methods: Three NSCLC cell lines, H1299 (deleted p53), A549 (wild-type p53), and H23 (mutated p53), were examined in the present investigation to represent NSCLC with different p53 functions. MTT assay was conducted to select suitable doses of cisplatin, resveratrol, and radiation for gene therapy, and dual luciferase assay was performed to validate the activation of promoter E9NS. The efficacy of gene therapy combinations was evaluated by the amount of GADD45α expression, cell survival, and apoptosis.Results: All the combinations successfully activated promoter E9NS to elevate intracellular GADD45α protein levels and subsequently enhanced cell viability reduction and apoptosis induction regardless of p53 status.Conclusion: Our study demonstrates that GADD45α-targeted suicide gene therapy controlled by synthetic promoter E9NS sensitizes NSCLC cells to cisplatin, resveratrol, and radiation and is effective against NSCLC at least in vitro.Keywords: GADD45α, gene therapy, inducible promoter, CArG element, apoptosis

Published
2019

35. Identification of stable heat tolerance QTLs using inter-specific recombinant inbred line population derived from GPF 2 and ILWC 292

Author

Kushwah, A., Bhatia, D., Singh, I., Thudi, M., Singh, G., Bindra, S., Vij, S., Gill, B.S., Bharadwaj, C., Singh, S., Varshney, R.K., Kushwah, A., Bhatia, D., Singh, I., Thudi, M., Singh, G., Bindra, S., Vij, S., Gill, B.S., Bharadwaj, C., Singh, S., and Varshney, R.K.

Abstract

Heat stress during reproductive stages has been leading to significant yield losses in chickpea (Cicer arietinum L.). With an aim of identifying the genomic regions or QTLs responsible for heat tolerance, 187 F8 recombinant inbred lines (RILs) derived from the cross GPF 2 (heat tolerant) × ILWC 292 (heat sensitive) were evaluated under late-sown irrigated (January-May) and timely-sown irrigated environments (November-April) at Ludhiana and Faridkot in Punjab, India for 13 heat tolerance related traits. The pooled ANOVA for both locations for the traits namely days to germination (DG), days to flowering initiation (DFI), days to 50% flowering (DFF), days to 100% flowering (DHF), plant height (PH), pods per plant (NPP), biomass (BIO), grain yield (YLD), 100-seed weight (HSW), harvest index (HI), membrane permeability index (MPI), relative leaf water content (RLWC) and pollen viability (PV)) showed a highly significant difference in RILs. The phenotyping data coupled with the genetic map comprising of 1365 ddRAD-Seq based SNP markers were used for identifying the QTLs for heat tolerance. Composite interval mapping provided a total of 28 and 23 QTLs, respectively at Ludhiana and Faridkot locations. Of these, 13 consensus QTLs for DG, DFI, DFF, DHF, PH, YLD, and MPI have been identified at both locations. Four QTL clusters containing QTLs for multiple traits were identified on the same genomic region at both locations. Stable QTLs for days to flowering can be one of the major factors for providing heat tolerance as early flowering has an advantage of more seed setting due to a comparatively longer reproductive period. Identified QTLs can be used in genomics-assisted breeding to develop heat stress-tolerant high yielding chickpea cultivars.

Published
2021

36. Early sedation with dexmedetomidine in ventilated critically ill patients and heterogeneity of treatment effect in the SPICE III randomised controlled trial.

Author

Abidin H.Z., Hassan M.H., Omar S.C., Shukeri W.F.W., Brealey D., Bercades G., Blackburn E., Macallum N., Macklin A., Ryu J.H., Tam K., Smyth D., Arif A., Bassford C., Morgan C., Swann C., Ward G., Wild L., Bone A., Elderkin T., Green D., Sach D., Salerno T., Simpson N., Brohi F., Clark M., Williams L., Brooks J., Cocks E., Cole J., Curtin J., Davies R., Hill H., Morgan M., Palmer N., Whitton C., Wise M., Baskaran P., Hasan M.S., Tham L.Y., Cruz R.S., Dinsdale D., Edney S., Firkin C., FitzJohn F., Hill G., Hunt A., Hurford S., Jones G., Judd H., Latimer-Bell C., Lawrence C., Lesona E., Navarra L., Robertson Y., Smellie H., Vucago A.M., Young P., Dawson H., Griffith D.M., Paterson R., Clark P., Kong J., Ho J., Nayyar V., Skelly C., Shehabi Y., Serpa Neto A., Howe B.D., Arabi Y.M., Bass F.E., Kadiman S.B., McArthur C.J., Reade M.C., Seppelt I.M., Wise M.P., Mashonganyika C., McKee H., Tonks A., Donnelly A., Hemmings N., O'Kane S., Blakemore A., Butler M., Cowdrey K., Dalton J., Gilder E., Long S., McCarthy L., McGuinness S., Parke R., Chen Y., McArthur C., McConnochie R., Newby L., Bellomo R., Eastwood G., Peck L., Young H., Boschert C., Edington J., Fletcher J., Nand K., Raza A., Sara T., Bennett-Britton J., Bewley J., Bodenham V., Cole L., Driver K., Grimmer L., Howie L., Searles C., Sweet K., Webster D., van Berkel A., Connor H., Dennett J., van Der Graaff M., Henderson S., Mehrtens J., Miller K., Minto E., Morris A., Noble S., Parker K., Hart N., Shepherd K., Vij S., Dickson S., Elloway E., Ferguson C., Jackson R., MacNaughton P., Marner M., Squire R., Waddy S., Wafer P., Welbourne J., Ashcroft P., Chambler D., Dukes S., Harris A., Horton S., Sharpe S., Williams P., Williams S., Bailey M., Blazquez E., France D., Hutchison R., Comadira G., Gough M., Tallott M., Bastick M., Cameron R., Donovan S., Gaur A., Gregory R., Naumoff J., Turner E., White M., Au K.F.J., Fratzia J., Treloar S., Lim C.H., Maseeda Y., Tan A.P., Tang C.L., Yong C.Y., Akaltan M., Berger S., Blaser D., Fazlija L., Jong M.L., Lensch M., Ludwig R., Merz T., Nettelbeck K., Roth M., Schafer M., Takala J., Wehr A., Zacharias D., Amran R., Ashraf H.N., Azmi N., Basri N., Burhanuddin H., Hadinata Y., Hamdan A., Kadiman S., Rashid A.I.Y.M., Sabran I.N., Sulaiman S., Zabidi I.N., Al-Dawood A., Aljuaid M., Al Anizi H., Al Saeedi A., Arabi Y., Dbsawy M., Deeb A., Hegazy M., Magdi I., Corcoran E., Finney C., Dumlao L.A., Bassam R., Hassan M.A., Naseem N., Al-Kurdi M.H., Al-Harthy A.M., Bernard S., Sebafundi L., Serban C., Lim S.K., Mazidah N., Saidin N., Sjamsuddin N., Tan I.T.A., Zabidi N., Brain M., Mineall S., Kanhere M., Soar N., Kadir N.A., Abdullah N.H., Awang R., Emperan Z., Husin N.S., Ismail N.I., Ismail S.Z., Khadzali F.N.A.M., Norddin M.F., Aguila J., Bold C., Clatworthy B., Dias A., Hogan C., Kazemi A., Lai V., Song R., Williams A., Bhatia D., Bulfin L., Elliot S., Galt P., Lavrans K., Ritchie P., Wang A., Gresham R., Lowrey J., Masters K., Palejs P., Seppelt I., Symonds F., Weisbrodt L., Whitehead C., Babio-Galan M., Calder V., Clement I., Harrison A., McCullagh I., Scott C., Bevan R., Caniba S., Hacking D., Maher L., Azzolini M.L., Beccaria P., Colombo S., Landoni G., Leggieri C., Luca C., Mamo D., Moizo E., Monti G., Mucci M., Zangrillo A., Albania M., Arora S., Shi Y., Abudayah A., Almekhlafi G., Al Amodi E., Al Samarrai S., Badawi M., Caba R.C., Elffaki O., Mandourah Y., Valerio J., Joyce C., Meyer J., Saylor E., Venkatesh B., Venz E., Walsham J., Wetzig K., Clarey E., Harris C., Hopkins P., Noble H., Thompson L., Williams T., Khoo T.M., Liew J.E.S., Sakthi A.N., Zulkurnain A., Bamford A., Bergin C., Carrera R., Cooper L., Despy L., Ellis K., Harkett S., Mee L., Reeves E., Snelson C., Spruce E., Cooper G., Hodgson R., Pearson D., Rosbergen M., Ali M.N., Bahar N.I., Ismail A., Ismail W.N.W., Samat N.M., Piah N.S.M., Rahman R.A., Duroux M., Ratcliffe M., Warhurst T., Buehner U., Williams E., Jacques N., Keating L., Macgill S., Tamang K.L., Tolan N., Walden A., Bower R., Cranshaw J., Molloy K., Pitts S., Butler J., Dunlop R., Fourie C., Jarrett P., Lassig-Smith M., Livermore A., O'Donoghue S., Reade M., Starr T., Stuart J., Campbell L., Phillips M., Stephens D., Thomas J., Cooper D., McAllister R., Andrew G., Barclay L., Hope D., Wojcik G., McCulloch C., Ascough L., Paisley C., Patrick-Heselton J., Shaw D., Waugh V., Williams K., Welters I., Barge D., Jordan A., MacIsaac C., Rechnitzer T., Bass F., Gatward J., Hammond N., Janin P., O'Connor A., Stedman W., Yarad E., Razak N.A., Dzulkipli N., Jong S.L., Asen K., Voon W.L., Liew S., Ball J., Barnes V., Dalton C., Farnell-Ward S., Farrah H., Maher K., Mellinghoff J., Ryan C., Shirley P., Conlon L., Glover A., Martin-Loeches I., O'Toole E., Ewan J., Ferrier J., Litton E., Webb S.A., Berry W., Alonso U.B., Bociek A., Campos S., Jawara S., Hanks F., Kelly A., Lei K., McKenzie C., Ostermann M., Wan R., Al-Soufi S., Leow S., McCann K., Reynolds C., Brickell K., Fahey C., Hays L., Hyde N., Nichol A., Ryan D., Brailsford J., Buckley A., Forbes L., Maguire T., Moore J., Murray L., Ghosh A., Park M., Said S., Smith J., Visser A., Ali S., Abidin H.Z., Hassan M.H., Omar S.C., Shukeri W.F.W., Brealey D., Bercades G., Blackburn E., Macallum N., Macklin A., Ryu J.H., Tam K., Smyth D., Arif A., Bassford C., Morgan C., Swann C., Ward G., Wild L., Bone A., Elderkin T., Green D., Sach D., Salerno T., Simpson N., Brohi F., Clark M., Williams L., Brooks J., Cocks E., Cole J., Curtin J., Davies R., Hill H., Morgan M., Palmer N., Whitton C., Wise M., Baskaran P., Hasan M.S., Tham L.Y., Cruz R.S., Dinsdale D., Edney S., Firkin C., FitzJohn F., Hill G., Hunt A., Hurford S., Jones G., Judd H., Latimer-Bell C., Lawrence C., Lesona E., Navarra L., Robertson Y., Smellie H., Vucago A.M., Young P., Dawson H., Griffith D.M., Paterson R., Clark P., Kong J., Ho J., Nayyar V., Skelly C., Shehabi Y., Serpa Neto A., Howe B.D., Arabi Y.M., Bass F.E., Kadiman S.B., McArthur C.J., Reade M.C., Seppelt I.M., Wise M.P., Mashonganyika C., McKee H., Tonks A., Donnelly A., Hemmings N., O'Kane S., Blakemore A., Butler M., Cowdrey K., Dalton J., Gilder E., Long S., McCarthy L., McGuinness S., Parke R., Chen Y., McArthur C., McConnochie R., Newby L., Bellomo R., Eastwood G., Peck L., Young H., Boschert C., Edington J., Fletcher J., Nand K., Raza A., Sara T., Bennett-Britton J., Bewley J., Bodenham V., Cole L., Driver K., Grimmer L., Howie L., Searles C., Sweet K., Webster D., van Berkel A., Connor H., Dennett J., van Der Graaff M., Henderson S., Mehrtens J., Miller K., Minto E., Morris A., Noble S., Parker K., Hart N., Shepherd K., Vij S., Dickson S., Elloway E., Ferguson C., Jackson R., MacNaughton P., Marner M., Squire R., Waddy S., Wafer P., Welbourne J., Ashcroft P., Chambler D., Dukes S., Harris A., Horton S., Sharpe S., Williams P., Williams S., Bailey M., Blazquez E., France D., Hutchison R., Comadira G., Gough M., Tallott M., Bastick M., Cameron R., Donovan S., Gaur A., Gregory R., 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Abstract

Purpose: To quantify potential heterogeneity of treatment effect (HTE), of early sedation with dexmedetomidine (DEX) compared with usual care, and identify patients who have a high probability of lower or higher 90-day mortality according to age, and other identified clusters. Method(s): Bayesian analysis of 3904 critically ill adult patients expected to receive invasive ventilation > 24 h and enrolled in a multinational randomized controlled trial comparing early DEX with usual care sedation. Result(s): HTE was assessed according to age and clusters (based on 12 baseline characteristics) using a Bayesian hierarchical models. DEX was associated with lower 90-day mortality compared to usual care in patients > 65 years (odds ratio [OR], 0.83 [95% credible interval [CrI] 0.68-1.00], with 97.7% probability of reduced mortality across broad categories of illness severity. Conversely, the probability of increased mortality in patients = 65 years was 98.5% (OR 1.26 [95% CrI 1.02-1.56]. Two clusters were identified: cluster 1 (976 patients) mostly operative, and cluster 2 (2346 patients), predominantly non-operative. There was a greater probability of benefit with DEX in cluster 1 (OR 0.86 [95% CrI 0.65-1.14]) across broad categories of age, with 86.4% probability that DEX is more beneficial in cluster 1 than cluster 2. Conclusion(s): In critically ill mechanically ventilated patients, early sedation with dexmedetomidine exhibited a high probability of reduced 90-day mortality in older patients regardless of operative or non-operative cluster status. Conversely, a high probability of increased 90-day mortality was observed in younger patients of non-operative status. Further studies are needed to confirm these findings.Copyright © 2021, Crown.

Published
2021

40. New-invexity type conditions with applications to constrained dynamic games

Author

Bhatia, D. and Sharma, A.

Subjects
Duality theory (Mathematics) -- Usage, Computer games -- Analysis, Computer game, Business, Business, general, Business, international
Abstract

Usage of duality theory to study symmetric dual variational problems and arrive at duality results, which are applicable in case of constrained dynamic games, is described.

Published
2003

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