1. Profile of Secondary Bacterial and Fungal Infections in Hospitalized COVID-19 Patients in a Tertiary Care Centre
- Author
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Bhat K A, Madi D, Bhat S, Mary T, Shenoy Mulki S, and Kotian H
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covid-19 ,sars cov 2 ,secondary infections ,klebsiella pneumoniae ,antibiotic resistance ,Infectious and parasitic diseases ,RC109-216 - Abstract
Archana Bhat K,1 Deepak Madi,2 Sevitha Bhat,1 Therese Mary,3 Shalini Shenoy Mulki,1 Himani Kotian4 1Department of Microbiology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India; 2Department of Medicine, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India; 3Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India; 4Department of Community Medicine, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, IndiaCorrespondence: Sevitha Bhat, Department of Microbiology Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India, Tel +91 9449831631, Email sevitha.bhat@manipal.eduIntroduction: SARS CoV-2, a novel corona virus, has emerged in December 2019. The COVID-19 associated mortality is documented in elderly with co morbidities. To have better insight on this issue, the secondary bacterial infections with multi-drug-resistant bacteria in COVID-19 patients need to be studied to evaluate the impact of these infections on the outcome.Aim and objectives: To determine the proportion of secondary infections in COVID-19 patients. To study the spectrum of pathogens and antibiogram of the bacteria isolated from secondary infections in such patients. To evaluate the co-existing co-morbidities, treatment and outcome in these patients.Methodology: The retrospective study was conducted in Departments of Medicine and Microbiology, KMC hospitals Attavara and Ambedkar circle, Mangaluru, including all the hospitalized microbiologically confirmed cases of SARS CoV-2 infection. Details pertaining to the study population were collected using a structured proforma. Descriptive data were entered in the form of mean, median and proportions. The categorical values were analyzed using Chi square test. Values of p < 0.05 were considered as statistically significant.Results: Two hundred COVID-19 hospitalized patients were included.28 out of 200 patients (14%) studied developed secondary infections. The types of secondary infections were Respiratory infections (50%), blood stream infections (17%), UTI (14%), Rhinocerebral Zygomycosis (17%). The predominant organisms were Klebsiella pneumoniae (44%), Zygomycetes (17%). The rates of antibiotic resistance in Gram negative bacilli were 33% to Cefuroxime,25% to aminoglycosides and fluoroquinolones and 16% to carbapenems. The mortality of 42.8% was observed in patients with secondary infections.Conclusion: Close monitoring and follow up especially in high-risk group of severe COVID 19 patients is crucial for better management and outcome.Keywords: COVID-19, SARS CoV 2, secondary infections, Klebsiella pneumoniae, antibiotic resistance
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- 2022