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Alzheimer's disease (AD) is a progressive neurological disorder characterized by memory loss, cognitive decline, and behavioral changes. Immunotherapy aims to harness the immune system to target the underlying pathology of AD and has shown promise as a disease-modifying treatment for AD. By focusing on the underlying disease pathogenesis and encouraging the removal of abnormal protein aggregates in the brain, immunotherapy shows promise as a potential treatment for AD. The development of immunotherapy for AD began with early attempts to use antibodies to target beta-amyloid. The amyloid hypothesis which suggests that the accumulation of beta-amyloid in the brain triggers the pathological cascade that leads to AD has been a driving force behind the development of immunotherapy for AD. However, recent clinical trials of monoclonal antibodies targeting amyloid-β have shown mixed results, highlighting the need for further research into alternative immunotherapy approaches. Additionally, the safety and efficacy of immunotherapy for AD remain an area of active investigation. Some immunotherapeutic approaches have shown promise, while others have been associated with significant side effects, including inflammation of the brain. Sleep has a significant impact on various physiological processes, including the immune system, and has been linked to the pathogenesis of AD. Thus, improving sleep quality and duration may benefit the immune system and potentially enhance the effectiveness of immunotherapeutic approaches for AD. In this review, we discussed the promises of immunotherapy as a disease-modifying treatment for AD as well as possible methods to improve the efficacy and safety of immunotherapy to achieve better therapeutic outcomes. [ABSTRACT FROM AUTHOR]

The article discusses the role of green nanotechnology in promoting environmental sustainability. It highlights the potential of nanotechnology in addressing global challenges and emphasizes the importance of integrating principles of environmental sustainability into nanotechnological methodologies. The article also presents various applications of green nanotechnology, such as renewable energy, environmental remediation, and biomedicine. It includes research articles that discuss the synthesis and characterization of nanoparticles, the impact of nanoparticle size on thermal efficiency, and the remediation of microplastics. The article concludes by emphasizing the need for government policies to ensure the eco-friendliness and safety of nanomaterials and processes. [Extracted from the article]

Mucuna pruriens, a rich source of L-dihydroxyphenylalanine, commonly known as L-DOPA and a precursor to dopamine, holds potential as a natural nutritional supplement. This study aimed to delve into the impact of incorporating M. pruriens seed powder (MpSP) into the feed on growth parameters and gonadal development of mono-sex common molly (Poecilia sphenops). The fish population was divided into three experimental groups, such as G1, G2, and G3, and a control group (C), each comprising 20 individuals. Over 45 days, the experimental groups were nourished with a commercial diet bolstered by MpSP in different concentrations (5, 7 and 10g/kg of feed, respectively). In contrast, the control group was provided with a regular diet devoid of the supplement. At the end of the experiment, MpSP demonstrated significant modulation (p<0.05) of growth performance metrics, including specific growth rate (SGR), length gain rate (LGR), body mass gain (BMG), and feed conversion ratio (FCR). Impressively, even the lower concentration of MpSP (5g/kg diet) yielded substantial increments in sperm count (p <0.05) and gonadosomatic index (GSI). These findings were corroborated by histological changes that reflected enhanced testicular development, consistently outperforming the control group. These outcomes collectively suggest the potential of velvet bean seed powder as a feasible, natural, and costeffective dietary supplement for enhancing growth and testicular development in mono-sex P. sphenops. [ABSTRACT FROM AUTHOR]

The article discusses the importance of prioritizing mental health care in India and highlights the potential of the QualityRights programme to improve mental health services. The programme, based on human rights principles, aims to enhance the quality of care, promote community involvement, and empower individuals with mental health conditions. By expanding the programme nationally, policymakers can create a more equitable society where mental health is recognized as a fundamental human right, leading to increased productivity and overall well-being. The success of the programme in Gujarat serves as a model for other states to adopt similar initiatives and work towards a more inclusive and effective mental healthcare system. [Extracted from the article]