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251 results on '"Bhasin, Manoj K."'

1. Mechanism of enhancing chemotherapy efficacy in pancreatic ductal adenocarcinoma with paricalcitol and hydroxychloroquine

Author

Nagaraju, Ganji Purnachandra, Saddala, Madhu Sudhana, Foote, Jeremy B., Khaliq, Ateeq M., Masood, Ashiq, Golivi, Yuvasri, Bandi, Dhana Sekhar Reddy, Sarvesh, Sujith, Reddy, Sudhir Putty, Switchenko, Jeffrey, Carstens, Julienne L., Akce, Mehmet, Herting, Cameron, Alese, Olatunji B., Yoon, Karina J., Manne, Upender, Bhasin, Manoj K., Lesinski, Gregory B., Sukhatme, Vikas P., and El-Rayes, Bassel F.

Published
2025
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4. Effect of indoximod-based chemo-immunotherapy in patients with pediatric brain tumors on activation and clonal proliferation of a circulating population of early non-exhausted stem-like CD8+ T cells whose on-treatment expansion is predictive of long-term outcome.

Author

Pacholczyk, Rafal, primary, Satpathy, Sarthak, additional, Berrong, Zuzana, additional, Chien, Franklin, additional, Huang, Chenbin, additional, Sadek, Ramses F., additional, Thomas, Beena E., additional, Smith, Christopher, additional, MacDonald, Tobey J., additional, Kennedy, Eugene Paul, additional, Johnson, Theodore S., additional, Bhasin, Manoj K., additional, and Munn, David H., additional

Published
2024
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5. Early Injury Landscape in Vein Harvest by Single-Cell and Spatial Transcriptomics

Author

Michaud, Marina E., primary, Mota, Lucas, additional, Bakhtiari, Mojtaba, additional, Thomas, Beena E., additional, Tomeo, John, additional, Pilcher, William, additional, Contreras, Mauricio, additional, Ferran, Christiane, additional, Bhasin, Swati, additional, Pradhan-Nabzdyk, Leena, additional, LoGerfo, Frank W., additional, Liang, Patric, additional, and Bhasin, Manoj K., additional

Published
2024
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6. Detecting Microbial Dysbiosis Associated with Pediatric Crohn Disease Despite the High Variability of the Gut Microbiota

Author

Wang, Feng, Kaplan, Jess L, Gold, Benjamin D, Bhasin, Manoj K, Ward, Naomi L, Kellermayer, Richard, Kirschner, Barbara S, Heyman, Melvin B, Dowd, Scot E, Cox, Stephen B, Dogan, Haluk, Steven, Blaire, Ferry, George D, Cohen, Stanley A, Baldassano, Robert N, Moran, Christopher J, Garnett, Elizabeth A, Drake, Lauren, Otu, Hasan H, Mirny, Leonid A, Libermann, Towia A, Winter, Harland S, and Korolev, Kirill S

Subjects
Microbiology, Biological Sciences, Emerging Infectious Diseases, Biodefense, Pediatric, Digestive Diseases, Prevention, Vaccine Related, Clinical Research, Crohn's Disease, Inflammatory Bowel Disease, Infection, Oral and gastrointestinal, Adolescent, Bacterial Typing Techniques, Case-Control Studies, Child, Child, Preschool, Crohn Disease, Dysbiosis, Feces, Humans, Infant, Microbiota, Biochemistry and Cell Biology, Medical Physiology, Biological sciences
Abstract

The relationship between the host and its microbiota is challenging to understand because both microbial communities and their environments are highly variable. We have developed a set of techniques based on population dynamics and information theory to address this challenge. These methods identify additional bacterial taxa associated with pediatric Crohn disease and can detect significant changes in microbial communities with fewer samples than previous statistical approaches required. We have also substantially improved the accuracy of the diagnosis based on the microbiota from stool samples, and we found that the ecological niche of a microbe predicts its role in Crohn disease. Bacteria typically residing in the lumen of healthy individuals decrease in disease, whereas bacteria typically residing on the mucosa of healthy individuals increase in disease. Our results also show that the associations with Crohn disease are evolutionarily conserved and provide a mutual information-based method to depict dysbiosis.

Published
2016

7. Comprehensive Genomic Profiling of High-Risk Pediatric Cancer Patients Has a Measurable Impact on Clinical Care

Author

Summers, Ryan J., Castellino, Sharon M., Porter, Christopher C., MacDonald, Tobey J., Basu, Gargi D., Szelinger, Szabolcs, Bhasin, Manoj K., Cash, Thomas, Carter, Alexis B., Castellino, Robert Craig, Fangusaro, Jason R., Mitchell, Sarah G., Pauly, Melinda G., Pencheva, Bojana, Wechsler, Daniel S., Graham, Douglas K., and Goldsmith, Kelly C.

Published
2022
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9. Integrated single-nuclei and spatial transcriptomic analysis reveals propagation of early acute vein harvest and distension injury signaling pathways following arterial implantation

Author

Michaud, Marina E., primary, Mota, Lucas, additional, Bakhtiari, Mojtaba, additional, Thomas, Beena E., additional, Tomeo, John, additional, Pilcher, William, additional, Contreras, Mauricio, additional, Ferran, Christiane, additional, Bhasin, Swati, additional, Pradhan-Nabzdyk, Leena, additional, LoGerfo, Frank W., additional, Liang, Patric, additional, and Bhasin, Manoj K., additional

Published
2023
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10. Indoximod-based chemo-immunotherapy for pediatric brain tumors: a first-in-children phase 1 trial

Author

Johnson, Theodore S, primary, MacDonald, Tobey J, additional, Pacholczyk, Rafal, additional, Aguilera, Dolly, additional, Al-Basheer, Ahmad, additional, Bajaj, Manish, additional, Bandopadhayay, Pratiti, additional, Berrong, Zuzana, additional, Bouffet, Eric, additional, Castellino, Robert C, additional, Dorris, Kathleen, additional, Eaton, Bree R, additional, Esiashvili, Natia, additional, Fangusaro, Jason R, additional, Foreman, Nicholas, additional, Fridlyand, Diana, additional, Giller, Cole, additional, Heger, Ian M, additional, Huang, Chenbin, additional, Kadom, Nadja, additional, Kennedy, Eugene P, additional, Manoharan, Neevika, additional, Martin, William, additional, McDonough, Colleen, additional, Parker, Rebecca S, additional, Ramaswamy, Vijay, additional, Ring, Eric, additional, Rojiani, Amyn, additional, Sadek, Ramses F, additional, Satpathy, Sarthak, additional, Schniederjan, Matthew, additional, Smith, Amy, additional, Smith, Christopher, additional, Thomas, Beena E, additional, Vaizer, Rachel, additional, Yeo, Kee Kiat, additional, Bhasin, Manoj K, additional, and Munn, David H, additional

Published
2023
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14. Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells

Author

Cea, Michele, Cagnetta, Antonia, Adamia, Sophia, Acharya, Chirag, Tai, Yu-Tzu, Fulciniti, Mariateresa, Ohguchi, Hiroto, Munshi, Aditya, Acharya, Prakrati, Bhasin, Manoj K., Zhong, Lei, Carrasco, Ruben, Monacelli, Fiammetta, Ballestrero, Alberto, Richardson, Paul, Gobbi, Marco, Lemoli, Roberto M., Munshi, Nikhil, Hideshima, Teru, Nencioni, Alessio, Chauhan, Dharminder, and Anderson, Kenneth C.

Published
2016
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17. Supplementary Table TS1 from Comprehensive Characterization of the Multiple Myeloma Immune Microenvironment Using Integrated scRNA-seq, CyTOF, and CITE-seq Analysis

Author

Yao, Lijun, primary, Jayasinghe, Reyka G., primary, Lee, Brian H., primary, Bhasin, Swati S., primary, Pilcher, William, primary, Doxie, Deon Bryant, primary, Gonzalez-Kozlova, Edgar, primary, Dasari, Surendra, primary, Fiala, Mark A., primary, Pita-Juarez, Yered, primary, Strausbauch, Michael, primary, Kelly, Geoffrey, primary, Thomas, Beena E., primary, Kumar, Shaji K., primary, Cho, Hearn Jay, primary, Anderson, Emilie, primary, Wendl, Michael C., primary, Dawson, Travis, primary, D'souza, Darwin, primary, Oh, Stephen T., primary, Cheloni, Giulia, primary, Li, Ying, primary, DiPersio, John F., primary, Rahman, Adeeb H., primary, Dhodapkar, Kavita M., primary, Kim-Schulze, Seunghee, primary, Vij, Ravi, primary, Vlachos, Ioannis S., primary, Mehr, Shaadi, primary, Hamilton, Mark, primary, Auclair, Daniel, primary, Kourelis, Taxiarchis, primary, Avigan, David, primary, Dhodapkar, Madhav V., primary, Gnjatic, Sacha, primary, Bhasin, Manoj K., primary, and Ding, Li, primary

Published
2023
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18. Supplementary Figure FS2 from Comprehensive Characterization of the Multiple Myeloma Immune Microenvironment Using Integrated scRNA-seq, CyTOF, and CITE-seq Analysis

Author

Yao, Lijun, primary, Jayasinghe, Reyka G., primary, Lee, Brian H., primary, Bhasin, Swati S., primary, Pilcher, William, primary, Doxie, Deon Bryant, primary, Gonzalez-Kozlova, Edgar, primary, Dasari, Surendra, primary, Fiala, Mark A., primary, Pita-Juarez, Yered, primary, Strausbauch, Michael, primary, Kelly, Geoffrey, primary, Thomas, Beena E., primary, Kumar, Shaji K., primary, Cho, Hearn Jay, primary, Anderson, Emilie, primary, Wendl, Michael C., primary, Dawson, Travis, primary, D'souza, Darwin, primary, Oh, Stephen T., primary, Cheloni, Giulia, primary, Li, Ying, primary, DiPersio, John F., primary, Rahman, Adeeb H., primary, Dhodapkar, Kavita M., primary, Kim-Schulze, Seunghee, primary, Vij, Ravi, primary, Vlachos, Ioannis S., primary, Mehr, Shaadi, primary, Hamilton, Mark, primary, Auclair, Daniel, primary, Kourelis, Taxiarchis, primary, Avigan, David, primary, Dhodapkar, Madhav V., primary, Gnjatic, Sacha, primary, Bhasin, Manoj K., primary, and Ding, Li, primary

Published
2023
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19. Data from Comprehensive Characterization of the Multiple Myeloma Immune Microenvironment Using Integrated scRNA-seq, CyTOF, and CITE-seq Analysis

Author

Yao, Lijun, primary, Jayasinghe, Reyka G., primary, Lee, Brian H., primary, Bhasin, Swati S., primary, Pilcher, William, primary, Doxie, Deon Bryant, primary, Gonzalez-Kozlova, Edgar, primary, Dasari, Surendra, primary, Fiala, Mark A., primary, Pita-Juarez, Yered, primary, Strausbauch, Michael, primary, Kelly, Geoffrey, primary, Thomas, Beena E., primary, Kumar, Shaji K., primary, Cho, Hearn Jay, primary, Anderson, Emilie, primary, Wendl, Michael C., primary, Dawson, Travis, primary, D'souza, Darwin, primary, Oh, Stephen T., primary, Cheloni, Giulia, primary, Li, Ying, primary, DiPersio, John F., primary, Rahman, Adeeb H., primary, Dhodapkar, Kavita M., primary, Kim-Schulze, Seunghee, primary, Vij, Ravi, primary, Vlachos, Ioannis S., primary, Mehr, Shaadi, primary, Hamilton, Mark, primary, Auclair, Daniel, primary, Kourelis, Taxiarchis, primary, Avigan, David, primary, Dhodapkar, Madhav V., primary, Gnjatic, Sacha, primary, Bhasin, Manoj K., primary, and Ding, Li, primary

Published
2023
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33. Data from Autocrine Canonical Wnt Signaling Primes Noncanonical Signaling through ROR1 in Metastatic Castration-Resistant Prostate Cancer

Author

Ma, Fen, primary, Arai, Seiji, primary, Wang, Keshan, primary, Calagua, Carla, primary, Yuan, Amanda R., primary, Poluben, Larysa, primary, Gu, Zhongkai, primary, Russo, Joshua W., primary, Einstein, David J., primary, Ye, Huihui, primary, He, Meng Xiao, primary, Liu, Yu, primary, Van Allen, Eliezer, primary, Sowalsky, Adam G., primary, Bhasin, Manoj K., primary, Yuan, Xin, primary, and Balk, Steven P., primary

Published
2023
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34. Supplementary Data from Autocrine Canonical Wnt Signaling Primes Noncanonical Signaling through ROR1 in Metastatic Castration-Resistant Prostate Cancer

Author

Ma, Fen, primary, Arai, Seiji, primary, Wang, Keshan, primary, Calagua, Carla, primary, Yuan, Amanda R., primary, Poluben, Larysa, primary, Gu, Zhongkai, primary, Russo, Joshua W., primary, Einstein, David J., primary, Ye, Huihui, primary, He, Meng Xiao, primary, Liu, Yu, primary, Van Allen, Eliezer, primary, Sowalsky, Adam G., primary, Bhasin, Manoj K., primary, Yuan, Xin, primary, and Balk, Steven P., primary

Published
2023
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35. Supplementary Figure from Autocrine Canonical Wnt Signaling Primes Noncanonical Signaling through ROR1 in Metastatic Castration-Resistant Prostate Cancer

Author

Ma, Fen, primary, Arai, Seiji, primary, Wang, Keshan, primary, Calagua, Carla, primary, Yuan, Amanda R., primary, Poluben, Larysa, primary, Gu, Zhongkai, primary, Russo, Joshua W., primary, Einstein, David J., primary, Ye, Huihui, primary, He, Meng Xiao, primary, Liu, Yu, primary, Van Allen, Eliezer, primary, Sowalsky, Adam G., primary, Bhasin, Manoj K., primary, Yuan, Xin, primary, and Balk, Steven P., primary

Published
2023
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36. MSC-Regulated MicroRNAs Converge on the Transcription Factor FOXP2 and Promote Breast Cancer Metastasis

Author

Cuiffo, Benjamin G., Campagne, Antoine, Bell, George W., Lembo, Antonio, Orso, Francesca, Lien, Evan C., Bhasin, Manoj K., Raimo, Monica, Hanson, Summer E., Marusyk, Andriy, El-Ashry, Dorraya, Hematti, Peiman, Polyak, Kornelia, Mechta-Grigoriou, Fatima, Mariani, Odette, Volinia, Stefano, Vincent-Salomon, Anne, Taverna, Daniela, and Karnoub, Antoine E.

Published
2014
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39. PGC1[alpha] drives NAD biosynthesis linking oxidative metabolism to renal protection

Author

Tran, Mei T., Zsengeller, Zsuzsanna K., Berg, Anders H., Khankin, Eliyahu V., Bhasin, Manoj K., Kim, Wondong, and Clish, Clary B.

Subjects
Biosynthesis -- Observations, NAD (Coenzyme) -- Health aspects, Kidneys -- Health aspects -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

PGC1[alpha] protects against kidney injury by upregulating enzymes that enhance nicotinamide adenine dinucleotide (NAD) and driving local accumulation of the fatty acid breakdown product [beta]-hydroxybutyrate, which leads to increased production of the renoprotective prostaglandin E.sub.2. Kidney protection by PGC1[alpha] Samir Parikh and colleagues show that the mitochondrial biogenesis regulator PGC1[alpha] protects against kidney injury by regulating NAD biosynthesis. In a mouse model, PGC1[alpha] upregulates NAMPT, an enzyme required form for NAD.sup.+ biosynthesis, and drives local accumulation of the fatty acid breakdown product [beta]-hydroxybutyrate. This, in turn, leads to increased production of the renoprotective prostaglandin PGE.sub.2. The authors further show that treatment with the NAD precursor nicotinamide (NAM) can reverse established ischaemic kidney injury. The energetic burden of continuously concentrating solutes against gradients along the tubule may render the kidney especially vulnerable to ischaemia. Acute kidney injury (AKI) affects 3% of all hospitalized patients.sup.1,2. Here we show that the mitochondrial biogenesis regulator, PGC1[alpha].sup.3,4, is a pivotal determinant of renal recovery from injury by regulating nicotinamide adenine dinucleotide (NAD) biosynthesis. Following renal ischaemia, Pgc1[alpha].sup.-/- (also known as Ppargc1a.sup.-/-) mice develop local deficiency of the NAD precursor niacinamide (NAM, also known as nicotinamide), marked fat accumulation, and failure to re-establish normal function. Notably, exogenous NAM improves local NAD levels, fat accumulation, and renal function in post-ischaemic Pgc1[alpha].sup.-/- mice. Inducible tubular transgenic mice (iNephPGC1[alpha]) recapitulate the effects of NAM supplementation, including more local NAD and less fat accumulation with better renal function after ischaemia. PGC1[alpha] coordinately upregulates the enzymes that synthesize NAD de novo from amino acids whereas PGC1[alpha] deficiency or AKI attenuates the de novo pathway. NAM enhances NAD via the enzyme NAMPT and augments production of the fat breakdown product [beta]-hydroxybutyrate, leading to increased production of prostaglandin PGE.sub.2 (ref. 5), a secreted autacoid that maintains renal function. NAM treatment reverses established ischaemic AKI and also prevented AKI in an unrelated toxic model. Inhibition of [beta]-hydroxybutyrate signalling or prostaglandin production similarly abolishes PGC1[alpha]-dependent renoprotection. Given the importance of mitochondrial health in ageing and the function of metabolically active organs, the results implicate NAM and NAD as key effectors for achieving PGC1[alpha]-dependent stress resistance., Author(s): Mei T. Tran [sup.1] [sup.2] , Zsuzsanna K. Zsengeller [sup.1] [sup.2] [sup.3] , Anders H. Berg [sup.3] [sup.4] , Eliyahu V. Khankin [sup.1] [sup.2] , Manoj K. Bhasin [sup.2] [...]

Published
2016
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40. Comprehensive Characterization of the Multiple Myeloma Immune Microenvironment Using Integrated scRNA-seq, CyTOF, and CITE-seq Analysis

Author

Yao, Lijun, primary, Jayasinghe, Reyka G., additional, Lee, Brian H., additional, Bhasin, Swati S., additional, Pilcher, William, additional, Doxie, Deon Bryant, additional, Gonzalez-Kozlova, Edgar, additional, Dasari, Surendra, additional, Fiala, Mark A., additional, Pita-Juarez, Yered, additional, Strausbauch, Michael, additional, Kelly, Geoffrey, additional, Thomas, Beena E., additional, Kumar, Shaji K., additional, Cho, Hearn Jay, additional, Anderson, Emilie, additional, Wendl, Michael C., additional, Dawson, Travis, additional, D'souza, Darwin, additional, Oh, Stephen T., additional, Cheloni, Giulia, additional, Li, Ying, additional, DiPersio, John F., additional, Rahman, Adeeb H., additional, Dhodapkar, Kavita M., additional, Kim-Schulze, Seunghee, additional, Vij, Ravi, additional, Vlachos, Ioannis S., additional, Mehr, Shaadi, additional, Hamilton, Mark, additional, Auclair, Daniel, additional, Kourelis, Taxiarchis, additional, Avigan, David, additional, Dhodapkar, Madhav V., additional, Gnjatic, Sacha, additional, Bhasin, Manoj K., additional, and Ding, Li, additional

Published
2022
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44. Autocrine Canonical Wnt Signaling Primes Noncanonical Signaling through ROR1 in Metastatic Castration-Resistant Prostate Cancer

Author

Ma, Fen, primary, Arai, Seiji, additional, Wang, Keshan, additional, Calagua, Carla, additional, Yuan, Amanda R., additional, Poluben, Larysa, additional, Gu, Zhongkai, additional, Russo, Joshua W., additional, Einstein, David J., additional, Ye, Huihui, additional, He, Meng Xiao, additional, Liu, Yu, additional, Van Allen, Eliezer, additional, Sowalsky, Adam G., additional, Bhasin, Manoj K., additional, Yuan, Xin, additional, and Balk, Steven P., additional

Published
2022
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48. TFEB-driven lysosomal biogenesis is pivotal for PGC1α-dependent renal stress resistance

Author

Lynch, Matthew R., primary, Tran, Mei T., additional, Ralto, Kenneth M., additional, Zsengeller, Zsuzsanna K., additional, Raman, Vinod, additional, Bhasin, Swati S., additional, Sun, Nuo, additional, Chen, Xiuying, additional, Brown, Daniel, additional, Rovira, Ilsa I., additional, Taguchi, Kensei, additional, Brooks, Craig R., additional, Stillman, Isaac E., additional, Bhasin, Manoj K., additional, Finkel, Toren, additional, and Parikh, Samir M., additional

Published
2020
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50. TFEB-driven lysosomal biogenesis is pivotal for PGC1α-dependent renal stress resistance

Author

Lynch, Matthew R., primary, Tran, Mei T., additional, Ralto, Kenneth M., additional, Zsengeller, Zsuzsanna K., additional, Raman, Vinod, additional, Bhasin, Swati S., additional, Sun, Nuo, additional, Chen, Xiuying, additional, Brown, Daniel, additional, Rovira, Ilsa I., additional, Taguchi, Kensei, additional, Brooks, Craig R., additional, Stillman, Isaac E., additional, Bhasin, Manoj K., additional, Finkel, Toren, additional, and Parikh, Samir M., additional

Published
2019
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